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Gold nanoparticles radiation

Peidang Liu, Haizhen Jin, Zhirui Guo, Jun Ma, Jing Zhao, Dongdong Li, Hao Wu, Ning Gu
Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation...
2016: International Journal of Nanomedicine
Roger M Pallares, Yusong Wang, Suo H Lim, Nguy N T K Thanh, Xiaodi Su
AIM: To develop a novel plasmonic nanosensing technique to monitor the exposure levels of UV light for sunlight disease prevention. METHODS: Anisotropic gold nanoparticles were grown inside a UV photoresponsive fluid, which was previously exposed to UV radiation from different sources. The morphology and optical properties of the obtained nanoparticles were monitored by spectroscopy and microscopy. RESULTS: The morphological and optical properties of the nanoparticles were dependent on the UV dose...
October 14, 2016: Nanomedicine
M Ravichandran, Goldie Oza, S Velumani, Jose Tapia Ramirez, Francisco Garcia-Sierra, Norma Barragan Andrade, A Vera, L Leija, Marco A Garza-Navarro
A multifunctional magneto-plasmonic CoFe2O4@Au core-shell nanoparticle was developed by iterative-seeding based method. This nanocargo consists of a cobalt ferrite kernel as a core (Nk) and multiple layers of gold as a functionalizable active stratum, (named as Nk@A after fifth iteration). Nk@A helps in augmenting the physiological stability and enhancing surface plasmon resonance (SPR) property. The targeted delivery of Doxorubicin using Nk@A as a nanopayload is demonstrated in this report. The drug release profile followed first order rate kinetics optimally at pH 5...
October 10, 2016: Scientific Reports
Mehdi Mousavi, Hassan Ali Nedaei, Samideh Khoei, Samira Eynali, Karim Khoshgard, Mostafa Robatjazi, Rasoul Iraji Rad
PURPOSE: Gold nanoparticles (GNP) have significant potential as radiosensitizer agents due to their distinctive properties. Several studies have shown that the surface modification of nanoparticles with methyl polyethylene glycol (mPEG) can increase their biocompatibility. However, the present study investigated the radiosensitization effects of mPEG-coated GNP (mPEG-GNP) in B16F10 murine melanoma cells under irradiation of 6 MeV Electron beam. MATERIALS AND METHODS: The synthesized GNP were characterized by UV-Visible spectroscopy, dynamic light scattering, transmission electron microscopy, and zeta potential...
October 5, 2016: International Journal of Radiation Biology
Hui Wang, Songjin Zhang, Xiumei Tian, Chufeng Liu, Lei Zhang, Wenyong Hu, Yuanzhi Shao, Li Li
Nanoprobes for combined optical and magnetic resonance imaging have tremendous potential in early cancer diagnosis. Gold nanoparticles (AuNPs) co-doped with Gd2O3 mesoporous silica nanocomposite (Au/Gd@MCM-41) can produce pronounced contrast enhancement for T1 weighted image in magnetic resonance imaging (MRI). Here, we show the remarkably high sensitivity of Au/Gd@MCM-41 to the human poorly differentiated nasopharyngeal carcinoma (NPC) cell line (CNE-2) using fluorescence lifetime imaging (FLIM). The upconversion luminescences from CNE-2 and the normal nasopharyngeal (NP) cells (NP69) after uptake of Au/Gd@MCM-41 show the characteristic of two-photon-induced-radiative recombination of the AuNPs...
October 3, 2016: Scientific Reports
Alihossein Saberi, Daryoush Shahbazi-Gahrouei, Mahdi Abbasian, Mehrafarin Fesharaki, Azam Baharlouei, Zahra Arab-Bafrani
PURPOSE: Gold nanoparticles (GNPs) act as a radiosensitizer in radiation therapy. However, recent studies have shown contradictory evidence in terms of radiosensitization in the presence of GNPs combined with x-ray megavoltage energy (MV) on different cell types. In this study, the effect of GNPs on radiosensitization enhancement of HT-29 human colorectal cancer cells at MV x-ray energy was evaluated. MATERIAL AND METHODS: The cytotoxicity and radiosensitization of GNPs were evaluated in HT-29 human colorectal cancer cells by MTS-assay and multiple MTS-assay, respectively...
October 3, 2016: International Journal of Radiation Biology
P H Wu, Y Onodera, Y Ichikawa, Y Watanabe, W Qian, T Hashimoto, H Shirato, J M Nam
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
D Brivio, P L Nguyen, E Sajo, W Ngwa, P Zygmanski
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Eric Ford, Jim Deye
There is a growing awareness of the gaps in the technical methods employed in radiation biology experiments. These quality gaps can have a substantial effect on the reliability and reproducibility of results as outlined in several recent meta-studies. This is especially true in the context of the newer laboratory irradiation technologies. These technologies allow for delivery of highly localized dose distributions and increased spatial accuracy but also present increased challenges of their own. In this article, we highlight some of the features of the new technologies and the experiments they support; this includes image-guided localized radiation systems, microirradiator systems using carbon nanotubes and physical radiation modifiers like gold nanoparticles...
October 2016: Seminars in Radiation Oncology
Atefeh Rostami, Mohammad Thaghi Bahreyni Toossi, Ameneh Sazgarnia, Shokouhozaman Soleymanifard
Due to biocompatibility and relative non-toxic nature, gold nanoparticles (GNPs) have been studied widely to be employed in radiotherapy as radio-sensitizer. On the other hand, they may enhance radiation-induced bystander effect (RIBE), which causes radiation adverse effects in non-irradiated normal cells. The present study was planned to investigate the possibility of augmenting the RIBE consequence of applying glucose-coated gold nanoparticles (Glu-GNPs) to target cells. Glu-GNPs were synthesized and utilized to treat MCF7 and QUDB cells...
September 9, 2016: Radiation and Environmental Biophysics
Md Habban Akhter, Saima Amin
Squamous cell carcinoma of skin has become an important matter of discussion worldwide due to high number of deaths. Treatment of such cancer involves use of drugs (chemotherapy) along with surgery or radiation therapy. The combination therapy is always preferred than single treatment modality due to poor internalization of most of the chemotherapeutics in the affected cells. Now a days, nanoparticle based drug delivery to squamous cell carcinoma is equanimous to become a leading therapeutic approach for cancer treatment...
September 6, 2016: Current Drug Delivery
Artur Mantel, Nazerke Shautenbaeva, Irina Irgibaeva, Anuar Aldongarov, Albina Lang, Nikolay Barashkov, Iskander Mukatayev
Four perylene derivatives, including commercially available dyes Lumogen Red and Lumogen Orange, as well as 1,6,7,12-tetrachlоrоperylene-3,4,9,10-tetradicarboxydianhydride (Dye I) and 3,4:9,10-bis(1,2-benzimidazole)- 1,6,7,12-tetra(4-tert-octylphenoxy) perylene (syn/ anti-isomers) (Dye III, which was prepared from dye I through intermediate 3,4:9,10-bis(1,2-benzimidazole)-1,6,7,12-tetrachloro perylene (Dye II)) were used for preparation of polysiloxane samples (PSi) containing different concentrations of gold nanoparticles (GN)...
September 3, 2016: Journal of Fluorescence
Fei Chen, Qingli Lin, Hongzhe Wang, Lei Wang, Fengjuan Zhang, Zuliang Du, Huaibin Shen, Lin Song Li
UNLABELLED: In this paper, the performance of quantum dot-based light-emitting diodes (QLEDs) comprising ZnCdSe/ZnS core-shell QDs as an emitting layer were enhanced by employing Au-doped poly(3,4-ethylenedioxythiophene)/polystyrene sulfonate ( PEDOT: PSS) hole injection layer (HIL). By varying the concentration and dimension of Au nanoparticle (NP) dopants in PEDOT: PSS, the optimal devices were obtained with ~22-nm-sized Au NP dopant at the concentration with an optical density (OD) of 0...
December 2016: Nanoscale Research Letters
Xi Liu, Yan Liu, Pengcheng Zhang, Xiaodong Jin, Xiaogang Zheng, Fei Ye, Weiqiang Chen, Qiang Li
Reductive drug-functionalized gold nanoparticles (AuNPs) have been proposed to enhance the damage of X-rays to cells through improving hydroxyl radical production by secondary electrons. In this work, polyethylene glycol-capped AuNPs were conjugated with tirapazamine (TPZ) moiety, and then thioctyl TPZ (TPZs)-modified AuNPs (TPZs-AuNPs) were synthesized. The TPZs-AuNPs were characterized by transmission electron microscopy, ultraviolet-visible spectra, dynamic light scattering, and inductively coupled plasma mass spectrometry to have a size of 16...
2016: International Journal of Nanomedicine
J Mertens, A Demetriadou, R W Bowman, F Benz, M-E Kleemann, C Tserkezis, Y Shi, H Y Yang, O Hess, J Aizpurua, J J Baumberg
We report the light-induced formation of conductive links across nanometer-wide insulating gaps. These are realized by incorporating spacers of molecules or 2D monolayers inside a gold plasmonic nanoparticle-on-mirror (NPoM) geometry. Laser irradiation of individual NPoMs controllably reshapes and tunes the plasmonic system, in some cases forming conductive bridges between particle and substrate, which shorts the nanometer-wide plasmonic gaps geometrically and electronically. Dark-field spectroscopy monitors the bridge formation in situ, revealing strong plasmonic mode mixing dominated by clear anticrossings...
September 14, 2016: Nano Letters
Abdollah Khorshidi
Medical nano-gold radioisotopes is produced regularly using high-flux nuclear reactors, and an accelerator-driven neutron activator can turn out higher yield of (197)Au(n,γ)(196,198)Au reactions. Here, nano-gold production via radiative/neutron capture was investigated using irradiated Tehran Research Reactor flux and also simulated proton beam of Karaj cyclotron in Iran. (197)Au nano-solution, including 20nm shaped spherical gold and water, was irradiated under Tehran reactor flux at 2.5E+13n/cm(2)/s for (196,198)Au activity and production yield estimations...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Jongmin Cho, Min Wang, Carlos Gonzalez-Lepera, Osama Mawlawi, Sang Hyun Cho
PURPOSE: Gold nanoparticles (GNPs) are being investigated actively for various applications in cancer diagnosis and therapy. As an effort to improve the imaging of GNPs in vivo, the authors developed bimetallic hybrid Zn@Au NPs with zinc cores and gold shells, aiming to render them in vivo visibility through positron emission tomography (PET) after the proton activation of the zinc core as well as capability to induce radiosensitization through the secondary electrons produced from the gold shell when irradiated by various radiation sources...
August 2016: Medical Physics
Naoki Yamamoto
A high-resolution cathodoluminescence (CL) system for scanning transmission electron microscope (STEM) has been developed by employing a field emission gun and a spherical aberration corrector, which realizes a probe size of 1 nm even at an accelerating voltage of 80 kV and beam current of the order of 1 nA. Angle resolved measurement of light emission from a sample in the STEM is possible by combining a parabolic mirror and position-controlled pinhole. CL spectra are successively acquired by a highly sensitive charge-coupled device while scanning the incident electron beam or pinhole, which enables various detection modes, i...
August 2016: Microscopy
Rafael Torres-Mendieta, David Ventura-Espinosa, Sara Sabater, Jesus Lancis, Gladys Mínguez-Vega, Jose A Mata
The demand for nanocomposites of graphene and carbonaceous materials decorated with metallic nanoparticles is increasing on account of their applications in science and technology. Traditionally, the production of graphene-metal assemblies is achieved by the non-environmentally friendly reduction of metallic salts in carbonaceous suspensions. However, precursor residues during nanoparticle growth may reduce their surface activity and promote cross-chemical undesired effects. In this work we present a laser-based alternative to synthesize ligand-free gold nanoparticles that are anchored onto the graphene surface in a single reaction step...
2016: Scientific Reports
Eduardo Pisano, Victor Coello, Cesar E Garcia-Ortiz, Yiting Chen, Jonas Beermann, Sergey I Bozhevolnyi
We report detailed characterization of surface plasmon-polariton guiding along 1-, 1.5- and 2-μm-wide channels in high-density (~75 μm<sup>-2</sup>) random arrays of gold 70-nm-high and 50-nm-wide nanoparticles fabricated on a 70-nm-thin gold film supported by a 170-μm-thick silica substrate. The mode propagation losses, effective index dispersion, and scattering parameters are characterized using leakage-radiation microscopy, in direct and Fourier planes, in the wavelength range of 740-840 nm...
July 25, 2016: Optics Express
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