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Gold nanoparticles radiation

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https://www.readbyqxmd.com/read/28727443/plasmonic-thermal-decomposition-digestion-of-proteins-a-rapid-on-surface-protein-digestion-technique-for-mass-spectrometry-imaging
#1
Rong Zhou, Franco Basile
A method based on plasmon surface resonance absorption and heating was developed to perform a rapid on-surface protein thermal decomposition and digestion suitable for imaging MS and/or profiling. This photo-thermal process or plasmonic thermal decomposition/digestion (plasmonic-TDD) method incorporates a continuous wave (CW) laser excitation and gold nanoparticles (Au-NPs) to induce known thermal decomposition reactions that cleave peptides and proteins specifically at the C-terminus of aspartic acid and at the N-terminus of cysteine...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28687649/imposed-environmental-stresses-facilitate-cell-free-nanoparticle-formation-by-deinococcus-radiodurans
#2
Angela Chen, Lydia M Contreras, Benjamin K Keitz
The biological synthesis of metal nanoparticles has been examined in a wide range of organisms due to increased interest in green synthesis and environmental remediation applications involving heavy metal ion contamination. Deinococcus radiodurans is particularly attractive for environmental remediation involving metal reduction due to its high resistance to radiation and other environmental stresses. However, few studies have thoroughly examined the relationship between environmental stresses and their resulting effect on nanoparticle biosynthesis...
July 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28666767/towards-breast-cancer-rotational-radiotherapy-with-synchrotron-radiation
#3
Francesca Di Lillo, Giovanni Mettivier, Antonio Sarno, Roberta Castriconi, Paolo Russo
PURPOSE: We performed the first investigations, via measurements and Monte Carlo simulations on phantoms, of the feasibility of a new technique for synchrotron radiation rotational radiotherapy for breast cancer (SR(3)T). METHODS: A Monte Carlo (MC) code based on Geant4 toolkit was developed in order to simulate the irradiation with the SR(3)T technique and to evaluate the skin sparing effect in terms of centre-to-periphery dose ratio at different energies in the range 60-175keV...
June 27, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28661675/hot-carrier-mediated-photon-upconversion-in-metal-decorated-quantum-wells
#4
Gururaj V Naik, Alex J Welch, Justin A Briggs, Michelle L Solomon, Jennifer A Dionne
Manipulating the frequency of electromagnetic waves forms the core of many modern technologies, ranging from imaging and spectroscopy to radio and optical communication. The process of converting photons from higher to lower energy is easily accomplished and technologically widespread. However, upconversion, which is the process of converting lower-energy photons into higher-energy photons, is still a growing field of study with nascent applications and burgeoning interest. Here, we experimentally demonstrate a new photon upconversion technique mediated by hot carriers in plasmonic nanostructures...
July 3, 2017: Nano Letters
https://www.readbyqxmd.com/read/28654384/fluorescent-plasmonic-and-radiotherapeutic-properties-of-the-177-lu-dendrimer-aunp-folate-bombesin-nanoprobe-located-inside-cancer-cells
#5
Héctor Mendoza-Nava, Guillermina Ferro-Flores, Flor de María Ramírez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Myrna Luna-Gutiérrez, Keila Isaac-Olivé
The integration of fluorescence and plasmonic properties into one molecule is of importance in developing multifunctional imaging and therapy nanoprobes. The aim of this research was to evaluate the fluorescent properties and the plasmonic-photothermal, therapeutic, and radiotherapeutic potential of (177)Lu-dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity ((177)Lu-DenAuNP-folate-bombesin) when it is internalized in T47D breast cancer cells. The intense near-Infrared (NIR) fluorescence emitted at 825 nm from the conjugate inside cells corroborated the usefulness of DenAuNP-folate-bombesin for optical imaging...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28595565/gold-nanoparticles-by-laser-ablation-for-x-ray-imaging-and-protontherapy-improvements
#6
Torrisi Lorenzo, Nancy Restuccia, Irene Paterniti
Gold nanoparticles, 5-20 nm in diameter, were generated with a pulsed Nd:YAG laser at 1010 W/cm2 at solution concentrations ranging between 1-100 mg/ml. Nanoparticles were characterized using optical absorbance, X-ray fluorescence, SEM, and TEM. Biocompatible nanoparticle solutions were injected by intravenously into the tail veins of mice followed by X-ray imaging using 20-45 keV photons to evaluate the uptake and the clearance by different organs of the nanoparticles. The incremental X-ray contrast imaging using gold nanoparticles was investigated and measured...
June 8, 2017: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/28585277/technical-note-monte-carlo-calculations-of-the-aapm-tg-43-brachytherapy-dosimetry-parameters-for-a-new-titanium-encapsulated-yb-169-source
#7
Francisco J Reynoso, John J Munro Iii, Sang Hyun Cho
Due to a number of distinct advantages resulting from the relatively low energy gamma ray spectrum of Yb-169, various designs of Yb-169 sources have been developed over the years for brachytherapy applications. Lately, Yb-169 has also been suggested as an effective and practical radioisotope option for a novel radiation treatment approach often known as gold nanoparticle-aided radiation therapy (GNRT). In a recently published study, the current investigators used the Monte Carlo N-Particle Version 5 (MCNP5) code to design a novel titanium-encapsulated Yb-169 source optimized for GNRT applications...
June 6, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28581292/photoinitiated-dynamics-in-amorphous-solid-water-via-nanoimprint-lithography
#8
Christopher Larson, Yuanrui Li, Wei Wu, Hanna Reisler, Curt Wittig
Laser pulses that act on fragile samples often alter them irreversibly, motivating single-pulse data collection. Amorphous solid water (ASW) is a good example. In addition, neither well-defined paths for molecules to travel through ASW nor sufficiently small samples to enable molecular dynamics modeling have been achieved. Combining nanoimprint lithography and photoinitiation overcomes these obstacles. An array of gold nanoparticles absorbs pulsed (10 ns) 532 nm radiation and converts it to heat, and doped ASW films grown at about 100 K are ejected from atop the irradiated nanoparticles into vacuum...
June 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28557630/the-exploitation-of-low-energy-electrons-in-cancer-treatment
#9
Mohammad Rezaee, Richard P Hill, David A Jaffray
Given the distinct characteristics of low-energy electrons (LEEs), particularly at energies less than 30 eV, they can be applied to a wide range of therapeutic modalities to improve cancer treatment. LEEs have been shown to efficiently produce complex molecular damage resulting in substantial cellular toxicities. Since LEEs are produced in copious amounts from high-energy radiation beam, including photons, protons and ions; the control of LEE distribution can potentially enhance the therapeutic radio of such beams...
August 2017: Radiation Research
https://www.readbyqxmd.com/read/28543610/metallic-nanoparticles-irradiated-by-low-energy-protons-for-radiation-therapy-are-there-significant-physical-effects-to-enhance-the-dose-delivery
#10
Anne-Catherine Heuskin, Bernard Gallez, Olivier Feron, Philippe Martinive, Carine Michiels, Stéphane Lucas
PURPOSE: To identify which physical properties of nanoparticles are correlated to the survival fraction of cells exposed in vitro to low energy protons in combination with nanoparticles. METHODS: The Geant4 simulation toolkit (version 10.3) was used to model nanoparticles of different sizes (5 to 50 nm) and materials (Ti, Zr, Hf, Ta, Au, Pt), with or without an organic capping ensuring biocompatibility and to irradiate them with 1.3 or 4 MeV protons and 5.3 MeV alpha particles...
May 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28520555/relaxation-lifetimes-of-plasmonically-enhanced-hybrid-gold-carbon-nanotubes-systems
#11
Mareen Gläske, Manoj Kumar, Timo Bißwanger, Saulius Vaitiekenas, Cesare Soci, Rohit Narula, Annalisa Bruno, Antonio Setaro
Recently, we introduced a novel hybridization route for carbon nanotubes using gold nanoparticles, whose close proximity neatly enhances their radiative emission. Here we investigate the mechanisms behind the enhancement by monitoring the de-excitation dynamics of our π-hybrids through two-color pump-probe time-resolved spectroscopy. The de-excitation process reveals a fast component and a slow component. We find that the presence of gold prominently affects the fast processes, indicating a stronger influence of the gold nanoparticle on the intra-band non-radiative relaxation than on the inter-band recombination of the SWNT...
May 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28509080/evaluation-of-dose-enhancement-in-presence-of-gold-nanoparticles-in-eye-brachytherapy-by-103-pd-source
#12
Hadi Rezaei, Mansour Zabihzadeh, Mahdi Ghorbani, Foad Goli Ahmadabad, Hesameddin Mostaghimi
In recent years, the use of gold nanoparticles in radiation therapy has been introduced as a new approach in radiotherapy. The aim of this study is to investigate the effect of gold nanoparticles (GNPs) in plaque brachytherapy for choroidal melanoma using Monte Carlo (MC) simulation. MCNPX code was used for simulation of human eye, (103)Pd (model 200) brachytherapy source and the 20 mm COMS eye plaque that was loaded with 24 (103)Pd seeds and standardized by Collaborative Ocular Melanoma Study (COMS). The tumour was defined from the inner surface of choroid with 0...
May 16, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28501783/silencing-of-dna-repair-sensitizes-pediatric-brain-tumor-cells-to-%C3%AE-irradiation-using-gold-nanoparticles
#13
Zuliang Liu, Huiru Yan, Hongsha Li
We present a nanoparticle (NP)-mediated delivery vehicle that effectively carries and protects siRNA in pediatric ependymoma (EP) and medulloblastoma (MB) cells. The delivery vehicle consists of gold NPs coated with a polymeric shell comprising polyethylene glycol (PG), chitosan and polyethyleneimine (Au-CP-PEI). NPs loaded with siRNA knocked down Ape1 expression by over 75% in both MB and EP cells. Further, this reduction in Ape1 expression is associated with an increase in DNA damage after irradiation. The results indicate that NP-associated delivery of siApe1 is a feasible approach to circumventing pediatric brain tumor resistance to radiation therapy...
July 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28499336/optical-properties-of-gold-nanoparticle-assemblies-on-a-glass-surface
#14
M O Stetsenko, S P Rudenko, L S Maksimenko, B K Serdega, O Pluchery, S V Snegir
The assemblies of cross-linked gold nanoparticles (AuNP) attract lot of scientific attention due to feasible perspectives of their use for development of scaled contact electrodes. Here, we developed and tested method of solid-state formation of dimers created from small AuNP (~18 nm) cross-linked with 1.9-nonadithiol (NDT) molecules. The morphology of created coating of a glass surface and its optical-polarization properties have been studied in detail by combination of scanning electron microscopy, atomic force microscopy, UV-visible spectroscopy, and modulation-polarization spectroscopy...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28497084/effects-of-radiofrequency-radiation-in-the-presence-of-gold-nanoparticles-for-the-treatment-of-renal-cell-carcinoma
#15
Safoora Nikzad, Golshan Mahmoudi, Payam Amini, Milad Baradaran-Ghahfarokhi, Akbar Vahdat-Moaddab, Seyedeh Maryam Sharafi, Leila Hojaji-Najafabadi, Ali Hosseinzadeh
Introduction: The most common type of kidney cancer is renal cell carcinoma (RCC), which accounts for more than 80% of all kidney cancers. Objectives: The aim of this study was to evaluate the effects of radiofrequency (RF) radiation in the presence of gold nanoparticles (GNPs) for the treatment of RCC. Materials and Methods: Human embryonic kidney (HEK) cancer cells were divided into 6 groups. Various tests were performed on HEK cells in the presence of RF and GNPs. In order to investigate the radiation effects on the cells' survival, MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-iphenyltetrazolium bromide] assay was performed at different days during and post-irradiation period...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28492507/core-shell-magnetic-gold-nanoparticles-for-magnetic-field-enhanced-radio-photothermal-therapy-in-cervical-cancer
#16
Rui Hu, Minxue Zheng, Jinchang Wu, Cheng Li, Danqing Shen, Dian Yang, Li Li, Mingfeng Ge, Zhimin Chang, Wenfei Dong
The combination of radiotherapy (RT) and photothermal therapy (PTT) has been considered an attractive strategy in cervical cancer treatment. However, it remains a challenge to simultaneously enhance the radio-sensitivity of tumor tissue, develop tumor tissue-focused radiation therapies and combine dual therapeutic modalities. In this study, core-shell type magnetic gold (Fe₃O₄@Au) nanoparticles are exploited to achieve the synergistic efficacy of radio-photothermal therapy in cervical cancer. Fe₃O₄@Au nanoparticles (NPs) with uniform morphology exhibited superior surface plasmon resonance properties, excellent superparamagnetic properties, good biocompatibility and high photothermal conversion efficiency...
May 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28486807/near-infrared-responsive-gold-layersome-nanoshells
#17
Akram Abbasi, Keunhan Park, Arijit Bose, Geoffrey D Bothun
Anionic liposomes coated with cationic polyelectrolyte poly-l-lysine (PLL), or layersomes, were used as soft, self-assembled templates for synthesizing gold nanoshells that absorb near-infrared radiation. The gold nanoshells were formed using two techniques: (a) direct reduction of tetrachloroauric acid on the layersomes and (b) the reduction of a tetrachloroauric acid/potassium carbonate "growth" solution on nanosized gold seeds bound to the surface of layersomes. The resulting structures were characterized by transmission and scanning electron microscopy and visible-near-infrared spectroscopy...
May 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28455135/sn38-conjugated-hyaluronic-acid-gold-nanoparticles-as-a-novel-system-against-metastatic-colon-cancer-cells
#18
Hosniyeh Hosseinzadeh, Fatemeh Atyabi, Behrang Shiri Varnamkhasti, Reza Hosseinzadeh, Seyed Nasser Ostad, Mohammad Hossein Ghahremani, Rassoul Dinarvand
Combination of chemotherapy and photothermal therapy has been proposed for better treatment of metastatic colon cancer. In this study SN38, a highly potent cytotoxic agent, was conjugated to negatively charged hyaluronic acid (HA), which was deposited on the surface of the positively charged gold nanoparticles via electrostatic interaction. The drug conjugation and its interaction with gold nanoparticles were verified by (1)H NMR and UV-vis spectroscopies, respectively. The prepared SN38-HA gold NPs are negatively charged spherical nanoparticles with an average size of 75±10nm...
April 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28429022/dependence-of-gold-nanoparticle-radiosensitization-on-cell-geometry
#19
Wonmo Sung, Sung-Joon Ye, Aimee L McNamara, Stephen J McMahon, James Hainfeld, Jungwook Shin, Henry M Smilowitz, Harald Paganetti, Jan Schuemann
The radiosensitization effect of gold nanoparticles (GNPs) has been demonstrated both in vitro and in vivo in radiation therapy. The purpose of this study was to systematically assess the biological effectiveness of GNPs distributed in the extracellular media for realistic cell geometries. TOPAS-nBio simulations were used to determine the nanometre-scale radial dose distributions around the GNPs, which were subsequently used to predict the radiation dose response of cells surrounded by GNPs. MDA-MB-231 human breast cancer cells and F-98 rat glioma cells were used as models to assess different cell geometries by changing (1) the cell shape, (2) the nucleus location within the cell, (3) the size of GNPs, and (4) the photon energy...
May 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28419319/influence-of-concentration-nanoparticle-size-beam-energy-and-material-on-dose-enhancement-in-radiation-therapy
#20
Chulhwan Hwang, Ja Mee Kim, JungHoon Kim
The purpose of this study was to analyse the effects of the type, concentration, and nanoparticle diameter of dose enhancement materials on the dose enhancement of low- and high-energy megavoltage (MV) X-rays acquired from a medical linear accelerator using Monte Carlo simulation. Monte Carlo simulation was performed with the Monte Carlo N-Particle Transport (MCNPX) code, using the energy spectrum of the linear accelerator and a mathematical Snyder head phantom. A 5-cm-diameter virtual tumour was defined in the centre of the phantom...
April 17, 2017: Journal of Radiation Research
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