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Gold nanoparticles radiation

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https://www.readbyqxmd.com/read/28195448/mitochondrion-anchoring-photosensitizer-with-aggregation-induced-emission-characteristics-synergistically-boosts-the-radiosensitivity-of-cancer-cells-to-ionizing-radiation
#1
Chris Y Y Yu, Huae Xu, Shenglu Ji, Ryan T K Kwok, Jacky W Y Lam, Xiaolin Li, Sunil Krishnan, Dan Ding, Ben Zhong Tang
The first mitochondrion-anchoring photosensitizer that specifically generates singlet oxygen ((1) O2 ) in mitochondria under white light irradiation that can serve as a highly effective radiosensitizer is reported here, significantly sensitizing cancer cells to ionizing radiation. An aggregation-induced emission luminogen (AIEgen), namely DPA-SCP, is rationally designed with α-cyanostilbene as a simple building block to reveal AIE, diphenylamino (DPA) group as a strong electron donating group to benefit red emission and efficient light-controlled (1) O2 generation, as well as a pyridinium salt as the targeting moiety to ensure specific mitochondrial localization...
February 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28151534/targeted-nanoparticles-for-tumour-radiotherapy-enhancement-the-long-dawn-of-a-golden-era
#2
Elisabetta Gargioni, Florian Schulz, Annette Raabe, Susanne Burdak-Rothkamm, Thorsten Rieckmann, Kai Rothkamm
Despite considerable progress in (I) our understanding of the aetiopathology of head and neck cancer and (II) the precise delivery of radiotherapy, long-term survival rates for many patients with head and neck cancer remain disappointingly low. Over the past years, gold nanoparticles (NP) have emerged as promising radiation dose enhancers. In a recent study published in Nanoscale, Popovtzer et al. have used gold NP coated with an antibody against the epidermal growth factor receptor (EGFR) in an attempt to enhance radiation-induced tumour cell killing in a head and neck cancer xenograft model...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28145723/ultrasmall-silica-based-bismuth-gadolinium-nanoparticles-for-dual-magnetic-resonance-computed-tomography-image-guided-radiation-therapy
#3
Alexandre Detappe, Eloise Thomas, Mark W Tibbitt, Sijumon Kunjachan, Oksana Zavidij, Nishita Parnandi, Elizaveta Reznichenko, François Lux, Olivier Tillement, Ross Berbeco
Selective killing of cancer cells while minimizing damage to healthy tissues is the goal of clinical radiation therapy. This therapeutic ratio can be improved by image-guided radiation delivery and selective radiosensitization of cancer cells. Here, we have designed and tested a novel trimodal theranostic nanoparticle made of bismuth and gadolinium for on-site radiosensitization and image contrast enhancement to improve the efficacy and accuracy of radiation therapy. We demonstrate in vivo magnetic resonance (MR), computed tomography (CT) contrast enhancement, and tumor suppression with prolonged survival in a non-small cell lung carcinoma model during clinical radiation therapy...
February 2, 2017: Nano Letters
https://www.readbyqxmd.com/read/28140338/a-monte-carlo-study-of-i-125-prostate-brachytherapy-with-gold-nanoparticles-dose-enhancement-with-simultaneous-rectal-dose-sparing-via-radiation-shielding
#4
D Brivio, P L Nguyen, E Sajo, W Ngwa, P Zygmanski
We investigate via Monte Carlo simulations a new (125)I brachytherapy treatment technique for high-risk prostate cancer patients via injection of Au nanoparticle (AuNP) directly into the prostate. The purpose of using the nanoparticles is to increase the therapeutic index via two synergistic effects: enhanced energy deposition within the prostate and simultaneous shielding of organs at risk from radiation escaping from the prostate. Both uniform and non-uniform concentrations of AuNP are studied. The latter are modeled considering the possibility of AuNP diffusion after the injection using brachy needles...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28134383/gold-nanotriangles-scale-up-and-x-ray-radiosensitization-effects-in-mice
#5
S R Bhattarai, P J Derry, K Aziz, P K Singh, A M Khoo, A S Chadha, A Liopo, E R Zubarev, S Krishnan
In the past decade, there has been considerable interest in radiosensitization using gold nanoparticles that accumulate specifically in cancerous tissue while sparing normal tissues. Despite this interest, it remains unclear which nanoparticle morphologies, cellular uptake, or cytoplasmic distribution elicit optimal radiosensitization. We introduce gold nanotriangles (AuNTs) as a possible X-ray radiotherapy sensitizer. In this study, we first explored a large-scale synthetic method for the production of high quality monodisperse AuNTs...
January 30, 2017: Nanoscale
https://www.readbyqxmd.com/read/28123993/synergetic-effects-of-silver-and-gold-nanoparticles-in-the-presence-of-radiofrequency-radiation-on-human-kidney-cells
#6
Jafar Fattahi-Asl, Mojtaba Karbalaee, Masoud Sanatizadeh, Payam Amini
OBJECTIVE: The aim of this study was to compare the effects of radiofrequency radiation (RF) in synergism with gold (Au) and silver (Ag) nanoparticles (NPs) on the survival fraction of human normal kidney (HNK) and human embryonic kidney (HEK) cells. MATERIALS AND METHODS: HNK and HEK cells were divided into three groups as control, 1 and 2 h/day-irradiated groups for 8 days. To compare the effects of RF in the presence of Au-NPs and Ag-NPs, the cells were incubated with NPs during the irradiation...
October 2016: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28112909/transdermal-vascular-endothelial-growth-factor-delivery-with-surface-engineered-gold-nanoparticles
#7
Ying Chen, Yonghui Wu, Jining Gao, Zihao Zhang, Linjie Wang, Xi Chen, Junwei Mi, Yuanjiang Yao, Dongwei Guan, Bing Chen, Jianwu Dai
Skin injuries caused by burns or radiation remain a serious concern in terms of clinical therapy. Because of the damage to the epidermis or dermis, angiogenesis is needed to repair the skin. Vascular endothelial growth factor (VEGF) is one of the most effective factors for promoting angiogenesis and preventing injury progression, but the delivery of VEGF to lesion sites is limited by the skin barrier. Recently, gold nanoparticle (AuNP)-mediated drug delivery into or through the epidermis and dermis has attracted much attention...
February 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28048930/su-f-t-54-determination-of-the-aapm-tg-43-brachytherapy-dosimetry-parameters-for-a-new-titanium-encapsulated-yb-169-source-by-monte-carlo-calculations
#8
F Reynoso, J Munro, S Cho
PURPOSE: To determine the AAPM TG-43 brachytherapy dosimetry parameters of a new titanium-encapsulated Yb-169 source designed to maximize the dose enhancement during gold nanoparticle-aided radiation therapy (GNRT). METHODS: An existing Monte Carlo (MC) model of the titanium-encapsulated Yb-169 source, which was described in the current investigators' published MC optimization study, was modified based on the source manufacturer's detailed specifications, resulting in an accurate model of the titanium-encapsulated Yb-169 source that was actually manufactured...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048528/we-h-206-01-photoacoustic-tomography-multiscale-imaging-from-organelles-to-patients-by-ultrasonically-beating-the-optical-diffusion-limit
#9
L Wang
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048346/su-f-t-660-evaluating-the-benefit-of-using-dual-function-fiducial-markers-for-in-situ-delivery-of-radiosenistizing-gold-nanoparticles-during-image-guided-radiotherapy
#10
S AlMansour, J Chin, E Sajo, W Ngwa
PURPOSE: Dual-function fiducials loaded with radiosensitizers, like gold nanoparticles (GNP), offer an innovative approach for ensuring geometric accuracy during image-guided radiotherapy (IGRT) and significantly increasing therapeutic efficacy due to controlled in-situ release of the radiosensitizers. This study retrospectively investigates the dosimetric benefit of using up to two such dual-function fiducial markers instead of traditional single function fiducials during IGRT. METHODS: A computational code was developed to investigate the dosimetric benefit for 10 real patient tumor volumes of up to 6...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048216/su-f-j-220-micro-ct-based-quantification-of-mouse-brain-vasculature-the-effects-of-acquisition-technique-and-contrast-material
#11
C Tipton, M Lamba, Z Qi, K LaSance, C Tipton
PURPOSE: Cognitive impairment from radiation therapy to the brain may be linked to the loss of total blood volume in the brain. To account for brain injury, it is crucial to develop an understanding of blood volume loss as a result of radiation therapy. This study investigates µCT based quantification of mouse brain vasculature, focusing on the effect of acquisition technique and contrast material. METHODS: Four mice were scanned on a µCT scanner (Siemens Inveon)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047869/we-h-206-02-recent-advances-in-multi-modality-molecular-imaging-of-small-animals
#12
B Tsui
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047205/we-h-206-03-promises-and-challenges-of-benchtop-x-ray-fluorescence-ct-xfct-for-quantitative-in-vivo-imaging
#13
S Cho
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047161/tu-h-campus-tep3-01-gold-nanoparticle-enhanced-radiation-therapy-in-in-vitro-a549-lung-carcinoma-studies-in-both-traditional-monolayer-and-three-dimensional-cell-culture-models
#14
M Oumano, W Ngwa, J Celli, M Arnoldussen, J Hanlon, J Hempstead, L Petrovic
PURPOSE: To measure the increase in in vitro radiosensitivity for A549 lung carcinoma cells due to gold nanoparticle (GNP) radiation dose enhancement in both traditional monolayer and three dimensional (3D) cell culture models. METHODS: A γH2AX immunofluorescence assay is performed on monolayer A549 cell culture and quantitatively analyzed to measure the increase in double strand breaks (DSBs) resulting from GNP dose enhancement. A clonogenic survival assay (CSA) is then performed on monolayer A549 cell culture to assess true viability after treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047003/su-g-tep3-04-evaluation-of-the-dose-enhancement-with-gold-nanoparticle-in-microdosimetry-level-using-the-geant4-dna-toolkit
#15
C He, J Chow
PURPOSE: This study investigated the dose enhancement effect of using gold nanoparticles (GNP) as radiation sensitizers radiated by different photon beam energies. Microdosimetry of photon-irradiated GNP was determined by the Geant4-DNA process in the DNA scale. METHODS: Monte Carlo simulation was conducted using the Geant4 toolkit (ver. 10.2). A GNP with different sizes (30, 50, and 100nm diameter sphere) and a DNA were placed in a water cube (1µm(3) ). The GNP was irradiated by photon beams with different energies (50, 100, and 150keV) and produced secondary electrons to increase the dose to the DNA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046495/tu-h-campus-tep3-02-in-situ-dose-painting-using-gold-nanoparticles-released-from-cylindrically-shaped-fiducials-during-external-beam-radiation-therapy
#16
R Mueller, Y Hao, J Hesser, W Ngwa
PURPOSE: Recent studies have shown that the presence of Gold Nanoparticles (GNPs) in tumor tissue can lead to significant dose enhancement (DE) during External Beam Radiation Therapy (EBRT). In this in-silico study we investigate EBRT with in-situ dose painting using GNPs released from cylindrically shaped GNP-loaded fiducials. METHODS: Reported Biologically Target/Tumor Volumes (BTVs) for 12 prostate carcinoma patients were employed in this study. Distribution of the GNPs after burst release from the fiducial (1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046461/we-h-206-00-advances-in-preclinical-imaging
#17
Patrick La Riviere
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046346/su-g-tep3-05-in-vitro-demonstration-of-endothelial-dose-enhancement-due-to-gold-nanoparticles-during-low-voltage-radiotherapy
#18
S Yasmin-Karim, M Moreau, R Kumar, G M Makrigiorgos, J Hanlon, M Arnoldussen, J Hempstead, J Celli, W Ngwa
PURPOSE: Oraya Therapy uses low-voltage, stereotactic, highly targeted X-rays for the treatment of wet age-related macular degeneration (AMD) - offering a new option for patients worldwide. Neovascular endothelial cells play a crucial role in the pathogenesis of this disease. This in-vitro study investigates the potential of gold nanoparticles (GNP) to enhance endothelial cell damage during low-voltage radiotherapy towards potential applications in the treatment of wet-AMD. METHODS: Primary human umbilical cord vein endothelium cells (HUVEC) were treated with 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044470/gold-nanoparticles-as-dose-enhancement-agent-for-kilovoltage-x-ray-therapy-of-melanoma
#19
So-Ra Kim, Eun-Hee Kim
PURPOSE: Melanoma is mainly treated by surgery and rarely with radiation because of the high radio-resistance of this tumor. Nevertheless, radiotherapy is the preferred treatment modality for unresectable lesions and avoiding cosmetic disfigurement caused by surgical excision. This study investigated the therapeutic advantage of gold nanoparticles (AuNPs) for kilovoltage X-ray treatment of melanoma. MATERIALS AND METHODS: Commercial AuNPs were evaluated for cytotoxicity and cellular internalization...
January 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28001308/heterogeneous-multiscale-monte-carlo-simulations-for-gold-nanoparticle-radiosensitization
#20
Martin P Martinov, Rowan M Thomson
PURPOSE: To introduce the heterogeneous multiscale (HetMS) model for Monte Carlo simulations of gold nanoparticle dose-enhanced radiation therapy (GNPT), a model characterized by its varying levels of detail on different length scales within a single phantom; to apply the HetMS model in two different scenarios relevant for GNPT and to compare computed results with others published. METHODS: The HetMS model is implemented using an extended version of the EGSnrc user-code egs_chamber; the extended code is tested and verified via comparisons with recently published data from independent GNP simulations...
December 21, 2016: Medical Physics
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