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Gold nanoparticles radiation

B Koger, C Kirkby
As a recent area of development in radiation therapy, gold nanoparticle (GNP) enhanced radiation therapy has shown potential to increase tumour dose while maintaining acceptable levels of healthy tissue toxicity. In this study, the effect of varying photon beam energy in GNP enhanced arc radiation therapy (GEART) is quantified through the introduction of a dose scoring metric, and GEART is compared to a conventional radiotherapy treatment. The PENELOPE Monte Carlo code was used to model several simple phantoms consisting of a spherical tumour containing GNPs (concentration: 15 mg Au g(-1) tumour, 0...
December 2, 2016: Physics in Medicine and Biology
Jiulong Li, Qinghao Li, Xiaoqiong Ma, Bing Tian, Tao Li, Jiangliu Yu, Shang Dai, Yulan Weng, Yuejin Hua
Deinococcus radiodurans is an extreme bacterium known for its high resistance to stresses including radiation and oxidants. The ability of D. radiodurans to reduce Au(III) and biosynthesize gold nanoparticles (AuNPs) was investigated in aqueous solution by ultraviolet and visible (UV/Vis) absorption spectroscopy, electron microscopy, X-ray diffraction (XRD), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). D. radiodurans efficiently synthesized AuNPs from 1 mM Au(III) solution in 8 h...
2016: International Journal of Nanomedicine
Sanjay Karna, Meg Mahat, Tae-Youl Choi, Ryoko Shimada, Zhiming Wang, Arup Neogi
The light emission from reduced graphene oxide quantum dots (rGO-QDs) exhibit a significant enhancement in photoluminescence (PL) due to localized surface plasmon (LSP) interactions. Silver and gold nanoparticles (NPs) coupled to rGO nanoparticles exhibit the effect of resonant LSP coupling on the emission processes. Enhancement of the radiative recombination rate in the presence of Ag-NPs induced LSP tuned to the emission energy results in a four-fold increase in PL intensity. The localized field due to the resonantly coupled LSP modes induces n-π* transitions that are not observed in the absence of the resonant interaction of the plasmons with the excitons...
November 22, 2016: Scientific Reports
Kaspar Haume, Soraia Rosa, Sophie Grellet, Małgorzata A Śmiałek, Karl T Butterworth, Andrey V Solov'yov, Kevin M Prise, Jon Golding, Nigel J Mason
Radiotherapy is currently used in around 50% of cancer treatments and relies on the deposition of energy directly into tumour tissue. Although it is generally effective, some of the deposited energy can adversely affect healthy tissue outside the tumour volume, especially in the case of photon radiation (gamma and X-rays). Improved radiotherapy outcomes can be achieved by employing ion beams due to the characteristic energy deposition curve which culminates in a localised, high radiation dose (in form of a Bragg peak)...
2016: Cancer Nanotechnology
Ning Zhao, Zhangru Yang, Bingxin Li, Jin Meng, Zeliang Shi, Ping Li, Shen Fu
Multifunctional nanoprobes have great potential as effective radiosensitizers and drug carriers. RGD-modified gold nanorods could increase the uptake of nanoparticles via receptor-mediated endocytosis in integrin alphaV beta3-overexpressing breast cancer cells, which could enhance the effects of radiation on tumor cells, leading to further radiosensitization. The purpose of our study was to demonstrate that RGD-conjugated mesoporous silica-encapsulated gold nanorods significantly enhanced the sensitization of triple-negative breast cancer to megavoltage energy...
2016: International Journal of Nanomedicine
Emiliano Cortés, Paloma Arroyo Huidobro, Hugo G Sinclair, Stina Guldbrand, William J Peveler, Timothy Davies, Simona Parrinello, Frederik Görlitz, Chris Dunsby, Mark A A Neil, Yonatan Sivan, Ivan P Parkin, Paul M W French, Stefan A Maier
Plasmonic nanoparticles influence the absorption and emission processes of nearby emitters due to local enhancements of the illuminating radiation and the photonic density of states. Here, we use the plasmon resonance of metal nanoparticles in order to enhance the stimulated depletion of excited molecules for super-resolved nanoscopy. We demonstrate stimulated emission depletion (STED) nanoscopy with gold nanorods with a long axis of only 26 nm and a width of 8 nm that provide an enhancement of up to 50% of the resolution compared to fluorescent-only probes without plasmonic components irradiated with the same depletion power...
October 30, 2016: ACS Nano
Minghan Shi, Benoit Paquette, Thititip Thippayamontri, Louis Gendron, Brigitte Guérin, Léon Sanche
The potential of gold nanoparticles (GNPs) as radiosensitizers for the treatment of malignant tumors has been limited by the large quantities of GNPs that must be administered and the requirement for low-energy X-ray irradiation to optimize radiosensitization. In this study, we enhance the radiosensitivity of HCT116 human colorectal cells with tiopronin-coated GNPs (Tio-GNPs) combined with a low-energy X-ray (26 keV effective energy) source, similar to the Papillon 50 clinical irradiator used for topical irradiation of rectal tumors...
2016: International Journal of Nanomedicine
Zhongli Cai, Niladri Chattopadhyay, Kaiyu Yang, Yongkyu Luke Kwon, Simmyung Yook, Jean-Philippe Pignol, Raymond M Reilly
INTRODUCTION: Gold nanoparticles (AuNP; 30nm) were modified with polyethylene glycol (PEG) chains linked to trastuzumab for binding to HER2-positive breast cancer (BC) cells and diethylenetriaminepentaacetic acid (DTPA) for complexing the Auger electron-emitter, (111)In (trastuzumab-AuNP-(111)In). Our objective was to determine the cytotoxicity of trastuzumab-AuNP-(111)In on HER2-positive BC cells in vitro and evaluate its tumor growth inhibition properties and normal tissue toxicity in vivo following intratumoral (i...
December 2016: Nuclear Medicine and Biology
Peidang Liu, Haizhen Jin, Zhirui Guo, Jun Ma, Jing Zhao, Dongdong Li, Hao Wu, Ning Gu
Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation...
2016: International Journal of Nanomedicine
Roger M Pallares, Yusong Wang, Suo H Lim, Nguy N T K Thanh, Xiaodi Su
AIM: To develop a novel plasmonic nanosensing technique to monitor the exposure levels of UV light for sunlight disease prevention. METHODS: Anisotropic gold nanoparticles were grown inside a UV photoresponsive fluid, which was previously exposed to UV radiation from different sources. The morphology and optical properties of the obtained nanoparticles were monitored by spectroscopy and microscopy. RESULTS: The morphological and optical properties of the nanoparticles were dependent on the UV dose...
October 14, 2016: Nanomedicine
M Ravichandran, Goldie Oza, S Velumani, Jose Tapia Ramirez, Francisco Garcia-Sierra, Norma Barragan Andrade, A Vera, L Leija, Marco A Garza-Navarro
A multifunctional magneto-plasmonic CoFe2O4@Au core-shell nanoparticle was developed by iterative-seeding based method. This nanocargo consists of a cobalt ferrite kernel as a core (Nk) and multiple layers of gold as a functionalizable active stratum, (named as Nk@A after fifth iteration). Nk@A helps in augmenting the physiological stability and enhancing surface plasmon resonance (SPR) property. The targeted delivery of Doxorubicin using Nk@A as a nanopayload is demonstrated in this report. The drug release profile followed first order rate kinetics optimally at pH 5...
October 10, 2016: Scientific Reports
Mehdi Mousavi, Hassan Ali Nedaei, Samideh Khoei, Samira Eynali, Karim Khoshgard, Mostafa Robatjazi, Rasoul Iraji Rad
PURPOSE: Gold nanoparticles (GNP) have significant potential as radiosensitizer agents due to their distinctive properties. Several studies have shown that the surface modification of nanoparticles with methyl polyethylene glycol (mPEG) can increase their biocompatibility. However, the present study investigated the radiosensitization effects of mPEG-coated GNP (mPEG-GNP) in B16F10 murine melanoma cells under irradiation of 6 MeV Electron beam. MATERIALS AND METHODS: The synthesized GNP were characterized by UV-Visible spectroscopy, dynamic light scattering, transmission electron microscopy, and zeta potential...
October 5, 2016: International Journal of Radiation Biology
Hui Wang, Songjin Zhang, Xiumei Tian, Chufeng Liu, Lei Zhang, Wenyong Hu, Yuanzhi Shao, Li Li
Nanoprobes for combined optical and magnetic resonance imaging have tremendous potential in early cancer diagnosis. Gold nanoparticles (AuNPs) co-doped with Gd2O3 mesoporous silica nanocomposite (Au/Gd@MCM-41) can produce pronounced contrast enhancement for T1 weighted image in magnetic resonance imaging (MRI). Here, we show the remarkably high sensitivity of Au/Gd@MCM-41 to the human poorly differentiated nasopharyngeal carcinoma (NPC) cell line (CNE-2) using fluorescence lifetime imaging (FLIM). The upconversion luminescences from CNE-2 and the normal nasopharyngeal (NP) cells (NP69) after uptake of Au/Gd@MCM-41 show the characteristic of two-photon-induced-radiative recombination of the AuNPs...
October 3, 2016: Scientific Reports
Alihossein Saberi, Daryoush Shahbazi-Gahrouei, Mahdi Abbasian, Mehrafarin Fesharaki, Azam Baharlouei, Zahra Arab-Bafrani
PURPOSE: Gold nanoparticles (GNPs) act as a radiosensitizer in radiation therapy. However, recent studies have shown contradictory evidence in terms of radiosensitization in the presence of GNPs combined with x-ray megavoltage energy (MV) on different cell types. In this study, the effect of GNPs on radiosensitization enhancement of HT-29 human colorectal cancer cells at MV x-ray energy was evaluated. MATERIAL AND METHODS: The cytotoxicity and radiosensitization of GNPs were evaluated in HT-29 human colorectal cancer cells by MTS-assay and multiple MTS-assay, respectively...
October 3, 2016: International Journal of Radiation Biology
P H Wu, Y Onodera, Y Ichikawa, Y Watanabe, W Qian, T Hashimoto, H Shirato, J M Nam
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
D Brivio, P L Nguyen, E Sajo, W Ngwa, P Zygmanski
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Eric Ford, Jim Deye
There is a growing awareness of the gaps in the technical methods employed in radiation biology experiments. These quality gaps can have a substantial effect on the reliability and reproducibility of results as outlined in several recent meta-studies. This is especially true in the context of the newer laboratory irradiation technologies. These technologies allow for delivery of highly localized dose distributions and increased spatial accuracy but also present increased challenges of their own. In this article, we highlight some of the features of the new technologies and the experiments they support; this includes image-guided localized radiation systems, microirradiator systems using carbon nanotubes and physical radiation modifiers like gold nanoparticles...
October 2016: Seminars in Radiation Oncology
Atefeh Rostami, Mohammad Thaghi Bahreyni Toossi, Ameneh Sazgarnia, Shokouhozaman Soleymanifard
Due to biocompatibility and relative non-toxic nature, gold nanoparticles (GNPs) have been studied widely to be employed in radiotherapy as radio-sensitizer. On the other hand, they may enhance radiation-induced bystander effect (RIBE), which causes radiation adverse effects in non-irradiated normal cells. The present study was planned to investigate the possibility of augmenting the RIBE consequence of applying glucose-coated gold nanoparticles (Glu-GNPs) to target cells. Glu-GNPs were synthesized and utilized to treat MCF7 and QUDB cells...
September 9, 2016: Radiation and Environmental Biophysics
Md Habban Akhter, Saima Amin
Squamous cell carcinoma of skin has become an important matter of discussion worldwide due to high number of deaths. Treatment of such cancer involves use of drugs (chemotherapy) along with surgery or radiation therapy. The combination therapy is always preferred than single treatment modality due to poor internalization of most of the chemotherapeutics in the affected cells. Now a days, nanoparticle based drug delivery to squamous cell carcinoma is equanimous to become a leading therapeutic approach for cancer treatment...
September 6, 2016: Current Drug Delivery
Artur Mantel, Nazerke Shautenbaeva, Irina Irgibaeva, Anuar Aldongarov, Albina Lang, Nikolay Barashkov, Iskander Mukatayev
Four perylene derivatives, including commercially available dyes Lumogen Red and Lumogen Orange, as well as 1,6,7,12-tetrachlоrоperylene-3,4,9,10-tetradicarboxydianhydride (Dye I) and 3,4:9,10-bis(1,2-benzimidazole)- 1,6,7,12-tetra(4-tert-octylphenoxy) perylene (syn/ anti-isomers) (Dye III, which was prepared from dye I through intermediate 3,4:9,10-bis(1,2-benzimidazole)-1,6,7,12-tetrachloro perylene (Dye II)) were used for preparation of polysiloxane samples (PSi) containing different concentrations of gold nanoparticles (GN)...
September 3, 2016: Journal of Fluorescence
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