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Neural tube defect and folic acid

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https://www.readbyqxmd.com/read/29133009/periconceptional-maternal-fever-folic-acid-intake-and-the-risk-for-neural-tube-defects
#1
Stephen M Kerr, Samantha E Parker, Allen A Mitchell, Sarah C Tinker, Martha M Werler
PURPOSE: Previous studies have shown an association between maternal fever in early pregnancy and neural tube defects (NTDs) such as spina bifida. Periconceptional folic acid intake has been shown to reduce the risk of these outcomes. METHODS: Using data from the Slone Epidemiology Center Birth Defects Study (1998-2015), we examined the impact of folic acid on the relationship between maternal fever in the periconceptional period (28 days before and after the last menstrual period) and NTDs...
November 2, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29128408/adding-folic-acid-to-corn-masa-flour-partnering-to-improve-pregnancy-outcomes-and-reduce-health-disparities
#2
REVIEW
Alina L Flores, Amy M Cordero, Michael Dunn, Joseph E Sniezek, Miguel A Arce, Krista S Crider, Sarah Tinker, Cynthia Pellegrini, Rita Carreón, Jose Estrada, Sara Struwe, Coleen Boyle
Although strides have been made in preventing neural tube defects (NTDs), Hispanic women remain more likely to have a baby born with an NTD and less likely to know the benefits of, or consume, folic acid than women of other race/ethnic groups. In 1998, the U.S. Food and Drug Administration (FDA) mandated that all enriched cereal grain products be fortified with folic acid; however, corn masa flour (CMF), used to make many corn products that are a diet staple of many Hispanic groups, was not included under this regulation...
November 8, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29125540/is-high-folic-acid-intake-a-risk-factor-for-autism-a-review
#3
REVIEW
Darrell Wiens, M Catherine DeSoto
Folate is required for metabolic processes and neural development. Insuring its adequate levels for pregnant women through supplementation of grain-based foods with synthetic folic acid (FA) in order to prevent neural tube defects has been an ongoing public health initiative. However, because women are advised to take multivitamins containing FA before and throughout pregnancy, the supplementation together with natural dietary folates has led to a demographic with high and rising serum levels of unmetabolized FA...
November 10, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29125506/should-the-dose-of-folic-acid-be-adjusted-for-mexican-population-the-pilot-prevention-program-implemented-in-nuevo-leon-mexico
#4
Laura E Martinez de Villarreal
In 1980 Smithells et al. reported that the intake of folic acid (FA) prevents the recurrence of neural tube defects (NTDs) [1]. After this and several other studies were conducted, the intake of 400 micrograms of folic acid per day, at least three months before and three months during pregnancy for prevention of NTD, was proposed [2,3,4]. Other strategies were also developed to increase folate blood levels in woman of childbearing age such as promoting the consumption of folate rich foods and food fortification (flour and most recently rice) [5]...
October 20, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29071735/impact-of-sample-collection-participation-on-the-validity-of-estimated-measures-of-association-in-the-national-birth-defects-prevention-study-when-assessing-gene-environment-interactions
#5
Mary M Jenkins, Jennita Reefhuis, Amy H Herring, Margaret A Honein
To better understand the impact that nonresponse for specimen collection has on the validity of estimates of association, we examined associations between self-reported maternal periconceptional smoking, folic acid use, or pregestational diabetes mellitus and six birth defects among families who did and did not submit buccal cell samples for DNA following a telephone interview as part of the National Birth Defects Prevention Study (NBDPS). Analyses included control families with live born infants who had no birth defects (N = 9,465), families of infants with anorectal atresia or stenosis (N = 873), limb reduction defects (N = 1,037), gastroschisis (N = 1,090), neural tube defects (N = 1,764), orofacial clefts (N = 3,836), or septal heart defects (N = 4,157)...
October 25, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/29069810/the-recurrence-risk-of-neural-tube-defects-ntds-in-a-population-with-high-prevalence-of-ntds-in-northern-china
#6
Jufen Liu, Zhiwen Li, Nicholas D E Greene, Hongtian Li, Aiguo Ren
BACKGROUND: Although a number of studies have reported the recurrence risk of NTDs in developed countries, there is little data on the rate of recurrence of NTDs in northern China, a region of high prevalence of NTDs. METHODS: Based on the population-based birth defects surveillance system of five counties, we identified women who had an NTD affected pregnancy from 2004-2015 and a retrospective survey was conducted. The rate of recurrence of NTDs was calculated by the number of recurrent NTDs divided by the first NTDs...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29059388/optimization-of-folic-acid-supplementation-in-the-prevention-of-neural-tube-defects
#7
Shona Cawley, Daniel McCartney, Jayne V Woodside, Mary Rose Sweeney, Robert McDonnell, Anne M Molloy, Michael J Turner
Background: We examined the relationship between timing and duration of folic acid (FA) supplementation in achieving red blood cell (RBC) folate levels in early pregnancy which are optimal (>906 nmol/l) for the prevention of neural tube defects (NTDs). Methods: Clinical, FA supplementation and dietary folate details were computerized at the first antenatal visit. Maternal blood samples were analysed for RBC and serum folate. Results: Of the 502 women, 98...
October 20, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29056972/methotrexate-and-valproic-acid-affect-early-neurogenesis-of-human-amniotic-fluid-stem-cells-from-myelomeningocele
#8
Vardine Sahakyan, Enrico Pozzo, Robin Duelen, Jan Deprest, Maurilio Sampaolesi
Myelomeningocele (MMC) is a severe type of neural tube defect (NTD), in which the backbone and spinal canal do not close completely during early embryonic development. This condition results in serious morbidity and increased mortality after birth. Folic acid significantly reduces, and conversely, folate antagonist methotrexate (MTX) and valproic acid (VPA) increase the occurrence of NTDs, including MMC. How these pharmacological agents exactly influence the early neurulation process is still largely unclear...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29052470/cautionary-note-about-magnitude-of-decline-in-neural-tube-birth-defects-following-folic-acid-fortification-in-the-united-states
#9
Harvey J Ginsburg, Roque V Mendez, Kelly B Haskar-Zolnierek
No abstract text is available yet for this article.
October 20, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28980068/a-unique-methylation-pattern-co-segregates-with-neural-tube-defect-statuses-in-han-chinese-pedigrees
#10
Ruiping Zhang, Lirong Cao, Yizheng Wang, Yulian Fang, Linsheng Zhao, Weidong Li, Ou-Yan Shi, Chun-Quan Cai
Neural tube defects (NTDs) are a complex trait associated with gene-environment interactions. Folic acid deficiency and planar cell polarity gene mutations account for some NTD cases; however, the etiology of NTDs is still little understood. In this study, in three Han Chinese NTD pedigrees (two with multiple affected children), with no information on folic acid deficiency or supplement, we examined genome-wide methylation profiles of each individual in these families. We further compared methylation status among cases and normal individuals within the pedigrees...
October 4, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28968208/efficacy-and-stability-studies-of-microbial-folate-fortified-fruit-juices-prepared-using-probiotic-microorganism
#11
S Deep, S Ojha, S Kundu
Folate, natural form of water soluble vitamin folic acid, is significant for humans as involved in most important metabolic reactions i.e. nucleotide synthesis and amino acid inter conversions. Thus its deficiency causes neural tube defects in newborns and cardiovascular diseases, and cancers. Humans cannot synthesize folate de novo so consumption through diet is essential. Natural food sources, supplements and fortified food products are the choices available to complete the Daily recommended intake. However microbial fortification using probiotics recently gained wide attention due to dual advantage of natural food matrix with enhanced folate content along with the probiotics benefits...
July 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28944587/finding-the-genetic-mechanisms-of-folate-deficiency-and-neural-tube-defects-leaving-no-stone-unturned
#12
REVIEW
Kit Sing Au, Tina O Findley, Hope Northrup
Neural tube defects (NTDs) occur secondary to failed closure of the neural tube between the third and fourth weeks of gestation. The worldwide incidence ranges from 0.3 to 200 per 10,000 births with the United States of American NTD incidence at around 3-6.3 per 10,000 dependent on race and socioeconomic background. Human NTD incidence has fallen by 35-50% in North America due to mandatory folic acid fortification of enriched cereal grain products since 1998. The US Food and Drug Administration has approved the folic acid fortification of corn masa flour with the goal to further reduce the incidence of NTDs, especially among individuals who are Hispanic...
November 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28934941/folic-acid-usage-and-associated-factors-in-the-prevention-of-neural-tube-defects-among-pregnant-women-in-ethiopia-cross-sectional-study
#13
Meselech Ambaw Dessie, Ejigu Gebeye Zeleke, Shimelash Bitew Workie, Ayanaw Worku Berihun
BACKGROUND: Neural tube defects are among the most common birth defects, contributing to miscarriage, infant mortality, severe congenital abnormalities and serious disabilities. It is burdensome to patients, caregivers, healthcare systems and society. It could be reduced if women consume a folic acid supplement before and during the early weeks of pregnancy. This study assesses folic acid usage and associated factors for the prevention of neural tube defects among pregnant women in Ethiopia...
September 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28930369/intake-of-folic-acid-by-polish-women-with-higher-education-a-survey-research-can-we-do-more
#14
Malwina Pietrzykowska-Kuncman, Dorota Zasina-Olaszek, Kuncman Łukasz, Marta Niedźwiecka, Krzysztof Szaflik, Iwona Maroszyńska
OBJECTIVES: The objective of the study is to determine efficacy of the Primary Prevention Program of Neural Tube Defects in Polish women with higher education in 5-year interval. MATERIAL AND METHODS: Survey research was conducted twice (in 2008 and 2013) in 630 female students of universities: 305 female medical students and 325 female non-medical students. The survey was also done among women aged 27- 35 who graduated from medical or non-medical universities and have at least one child...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28885600/a-cross-sectional-study-of-dietary-and-genetic-predictors-of-blood-folate-levels-in-healthy-young-adults
#15
Daniel Cummings, Kevin F Dowling, Noah J Silverstein, Alexandra S Tanner, Hamdi Eryilmaz, Jordan W Smoller, Joshua L Roffman
Since 1998, the U.S. has mandated folic acid (FA) fortification of certain grain products to reduce the risk of neural tube defects. Folate intake and red blood cell (RBC) folate concentrations increased substantially post-intervention, although recent studies raise concerns about the level of ongoing benefit. This study investigated blood folate level determinants in healthy young adults, including intake of naturally occurring food folate, synthetic FA, and the interaction of naturally occurring food folate with a common missense variant in the FOLH1 gene thought to affect absorption...
September 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28873613/simple-coupled-ultrahigh-performance-liquid-chromatography-and-ion-chromatography-technique-for-simultaneous-determination-of-folic-acid-and-inorganic-anions-in-folic-acid-tablets
#16
Fenglian Wang, Minyi Cao, Nani Wang, Nadeem Muhammad, Shuchao Wu, Yan Zhu
Folic acid plays a significant role during periods of rapid cells division and growth. Pregnant women require folic acid daily, either from dietary supplements or folic acid tablets in order to prevent fetal neural tube defects. In this work, a simple coupled ultrahigh performance liquid chromatography and ion chromatography technique was developed for simultaneous determination of folic acid and inorganic anions in folic acid tablets. A reversed-phase C18 column was used as the pretreatment column for on-line separating inorganic anions from organics...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28844822/diet-and-fertility-a-review
#17
REVIEW
Audrey J Gaskins, Jorge E Chavarro
The literature on the relationship between diet and human fertility has greatly expanded over the last decade, resulting in the identification of a few clear patterns. Intake of supplemental folic acid, particularly at doses higher than those recommended for the prevention of neural tube defects, has been consistently related to lower frequency of infertility, lower risk of pregnancy loss, and greater success in infertility treatment. On the other hand and despite promising evidence from animal models, vitamin D does not appear to exert an important role in human fertility in the absence of deficiency...
August 24, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28818086/mediterranean-diet-folic-acid-and-neural-tube-defects
#18
REVIEW
Maximilian Fischer, Mauro Stronati, Marcello Lanari
The Mediterranean diet has been for a very long time the basis of food habits all over the countries of the Mediterranean basin, originally founded on rural models and low consumption of meat products and high-fat/high-processed foods. However, in the modern era, the traditional Mediterranean diet pattern is now progressively eroding due to the widespread dissemination of the Western-type economy, life-style, technology-driven culture, as well as the globalisation of food production, availability and consumption, with consequent homogenisation of food culture and behaviours...
August 17, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28797054/large-scale-wheat-flour-folic-acid-fortification-program-increases-plasma-folate-levels-among-women-of-reproductive-age-in-urban-tanzania
#19
Ramadhani A Noor, Ajibola I Abioye, Nzovu Ulenga, Salum Msham, George Kaishozi, Nilupa S Gunaratna, Ramadhani Mwiru, Erin Smith, Christina Nyhus Dhillon, Donna Spiegelman, Wafaie Fawzi
There is widespread vitamin and mineral deficiency problem in Tanzania with known deficiencies of at least vitamin A, iron, folate and zinc, resulting in lasting negative consequences especially on maternal health, cognitive development and thus the nation's economic potential. Folate deficiency is associated with significant adverse health effects among women of reproductive age, including a higher risk of neural tube defects. Several countries, including Tanzania, have implemented mandatory fortification of wheat and maize flour but evidence on the effectiveness of these programs in developing countries remains limited...
2017: PloS One
https://www.readbyqxmd.com/read/28770950/prevention-of-neural-tube-defects-and-maternal-gestational-diabetes-through-the-inositol-supplementation-preliminary-results
#20
D Dell'Edera, F Sarlo, A Allegretti, A A Epifania, F Simone, M G Lupo, M Benedetto, M R D'Apice, A Capalbo
OBJECTIVE: Our study aims to demonstrate that the use in the preconceptional period until the 24th week of pregnancy of inositol and folic acid, first of all, preserves the product of conception from neural tube defects (NTDs) and then, thanks to inositol supplementation, it possibly counteracts and prevents the onset of maternal gestational diabetes (GDM). PATIENTS AND METHODS: We have collected data derived from pregnant women arrived at our laboratory, from January 2014 to January 2016, with no family history of type 2 diabetes and hypertension...
July 2017: European Review for Medical and Pharmacological Sciences
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