keyword
MENU ▼
Read by QxMD icon Read
search

Medroxyprogesterone acetate

keyword
https://www.readbyqxmd.com/read/29771679/acceptability-of-contraceptive-self-injection-with-dmpa-sc-among-adolescents-in-gulu-district-uganda
#1
Jane Cover, Jeanette Lim, Allen Namagembe, Justine Tumusiime, Jennifer Kidwell Drake, Carie Muntifering Cox
CONTEXT: In Uganda, an estimated one in four adolescent women have begun childbearing. Many adolescent pregnancies are unintended because of substantial barriers to contraceptive access. The injectable contraceptive is the most commonly used method in Uganda, and a new subcutaneous version offers the possibility of reducing access barriers by offering a self-injection option. However, more information about adolescent attitudes toward and interest in self-injection is needed. METHODS: In 2015, in-depth interviews were conducted with a purposive sample of 46 adolescent women aged 15-19 from rural and urban areas of Gulu District...
December 1, 2017: International Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29768475/conjugated-equine-estrogen-and-medroxyprogesterone-acetate-are-associated-with-decreased-risk-of-breast-cancer-relative-to-bioidentical-hormone-therapy-and-controls
#2
Zexian Zeng, Xia Jiang, Xiaoyu Li, Alan Wells, Yuan Luo, Richard Neapolitan
OBJECTIVE: By the 1990s it became popular for women to use hormone therapy (HT) to ease menopause symptoms. Bioidentical estrogen and progesterone are supplements whose molecular structures are identical to what is made in the human body, while synthetic supplements are ones whose structures are not. After the Women's Health Initiative found that the combined use of the synthetics conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA) increased breast cancer risk, prescriptions for synthetic HT declined considerably...
2018: PloS One
https://www.readbyqxmd.com/read/29758176/women-s-satisfaction-use-storage-and-disposal-of-subcutaneous-depot-medroxyprogesterone-acetate-dmpa-sc-during-a-randomized-trial
#3
Holly M Burke, Mario Chen, Mercy Buluzi, Rachael Fuchs, Silver Wevill, Lalitha Venkatasubramanian, Leila Dal Santo, Bagrey Ngwira
OBJECTIVE: To describe women's experiences with subcutaneous depot medroxyprogesterone acetate (DMPA-SC) to inform scale-up of self-administered DMPA-SC. STUDY DESIGN: We conducted a 12-month randomized controlled trial in Malawi to measure DMPA-SC continuation rates. A total of 731 women presenting at six Ministry of Health clinics or to community health workers (CHWs) in rural communities were randomized to receive DMPA-SC administered by a provider, or be trained to self-inject DMPA-SC...
May 11, 2018: Contraception
https://www.readbyqxmd.com/read/29746813/effect-of-the-depot-medroxyprogesterone-acetate-injectable-and-levonorgestrel-implant-on-hiv-genital-shedding-a-randomized-trial
#4
Lameck Chinula, Julie A E Nelson, Jeffrey Wiener, Jennifer H Tang, Stacey Hurst, Gerald Tegha, Albans Msika, Sascha Ellington, Mina C Hosseinipour, Ronald Mataya, Lisa B Haddad, Athena P Kourtis
OBJECTIVES: To assess the effect of the depot medroxyprogesterone acetate injectable (DMPA) and of the levonorgestrel (LNG)-implant on genital HIV shedding among women receiving antiretroviral therapy (ART). METHODS: We randomized HIV-infected Malawian women to either DMPA or LNG-implant from May 2014 to April 2015. HIV RNA was measured in cervicovaginal lavage (CVL) fluid and TearFlo Strips (TFS), and HIV DNA was measured in cells collected by CVL. We compared the frequency and magnitude of HIV genital shedding before and for 6months after initiation of contraception and between arms among women receiving ART...
May 7, 2018: Contraception
https://www.readbyqxmd.com/read/29733817/predictors-of-dmpa-sc-continuation-among-urban-nigerian-women-the-influence-of-counseling-quality-and-side-effects
#5
Jenny Liu, Jennifer Shen, Nadia Diamond-Smith
OBJECTIVES: In 2015, private healthcare providers in Nigeria introduced DMPA-SC (depot medroxyprogesterone acetate administered subcutaneously) into the method mix. We aimed to [1] examine the sociodemographic predictors of continued DMPA-SC use after three months, and [2] characterize the additional influences of contraceptive counseling quality and experiences of side effects on continuation. STUDY DESIGN: From March to August, 2016, we conducted phone interviews with a convenience sample of women obtaining DMPA-SC from selected providers to survey them about their experience obtaining an initial dose of DMPA-SC...
May 4, 2018: Contraception
https://www.readbyqxmd.com/read/29706227/client-and-provider-experiences-with-self-administration-of-subcutaneous-depot-medroxyprogesterone-acetate-dmpa-sc-in-malawi
#6
Holly M Burke, Catherine Packer, Mercy Buluzi, Elise Healy, Bagrey Ngwira
OBJECTIVE: As low- and middle-income countries (LMICs) consider adding self-administration of subcutaneous depot medroxyprogesterone acetate (DMPA-SC) to their contraceptive method mix, learning about family planning clients' and providers' experiences with self-injectable DMPA-SC during trials will inform introduction and scale-up efforts. STUDY DESIGN: We conducted semistructured interviews with 30 randomly selected adult women enrolled in the self-administration group of a 12-month randomized controlled trial studying DMPA-SC continuation rates in rural Malawi...
April 4, 2018: Contraception
https://www.readbyqxmd.com/read/29698514/medroxyprogesterone-acetate-unlike-norethisterone-increases-hiv-1-replication-in-human-peripheral-blood-mononuclear-cells-and-an-indicator-cell-line-via-mechanisms-involving-the-glucocorticoid-receptor-increased-cd4-cd8-ratios-and-ccr5-levels
#7
Michelle F Maritz, Roslyn M Ray, Alexis J Bick, Michele Tomasicchio, John G Woodland, Yashini Govender, Chanel Avenant, Janet P Hapgood
High usage of progestin-only injectable contraceptives, which include the intramuscular injectables depo-medroxyprogesterone acetate (DMPA-IM, Depo-Provera) and norethisterone (NET) enanthate (NET-EN or Nur-Isterate), correlates worldwide with areas of high HIV-1 prevalence. Epidemiological data show a significant association between usage of DMPA-IM and increased HIV-1 acquisition but no such association from limited data for NET-EN. Whether MPA and NET have similar effects on HIV-1 acquisition and pathogenesis, and the relationship between these effects and the dose of MPA, are critical issues for women's health and access to suitable and safe contraceptives...
2018: PloS One
https://www.readbyqxmd.com/read/29694506/dietary-intake-and-eating-behavior-in-depot-medroxyprogesterone-acetate-users-a-systematic-review
#8
P Silva, S Qadir, A Fernandes, L Bahamondes, J F Peipert
Because of weight gain, women often discontinue hormonal contraception, especially depot medroxyprogesterone acetate (DMPA). Our objective was to conduct a systematic review of studies describing dietary intake or eating behavior in DMPA users to understand whether the use of DMPA is associated with changes in dietary habits and behaviors leading to weight gain. We searched the PubMed, POPLINE, CENTRAL Cochrane, Web of Science, and EMBASE databases for reports published in English between 1980 and 2017 examining dietary intake or eating behavior in healthy women in reproductive age and adolescents using DMPA (150 mg/mL)...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29671344/subclinical-cardiovascular-disease-parameters-after-one-year-in-new-users-of-depot-medroxyprogesterone-acetate-compared-to-copper-iud
#9
Kleber Cursino, Gabriel Araújo de Lima, Priscilla de Nazaré Silva Dos Santos, Elizabeth João Pavin, Luis Bahamondes, Arlete Fernandes
PURPOSE: To evaluate markers of cardiovascular disease in women with normal insulin sensitivity who had recently initiated use of depot medroxyprogesterone acetate (DMPA) as a contraceptive. MATERIALS AND METHODS: A prospective, non-randomised, comparative study. Data of 30 women of 18-40 years of age, with normal hyperinsulinaemic-euglycaemic clamp at baseline and body mass index (BMI) < 30, who opted to use DMPA or a copper intrauterine device (IUD) as a contraceptive, were analysed...
April 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29669335/antenatal-corticosteroid-exposure-disrupts-myelination-in-the-auditory-nerve-of-preterm-sheep
#10
Judith Rittenschober-Böhm, Jennifer Rodger, Alan H Jobe, Suhas G Kallapur, Dorota A Doherty, Boris W Kramer, Matthew S Payne, Michael Archer, Christian Rittenschober, John P Newnham, Yuichiro Miura, Angelika Berger, Stephen G Matthews, Matthew W Kemp
BACKGROUND: Antenatal corticosteroids (ACS) improve preterm neonatal outcomes. However, uncertainty remains regarding the safety of ACS exposure for the developing fetus, particularly its neurosensory development. OBJECTIVES: We investigated the effect of single and multiple ACS exposures on auditory nerve development in an ovine model of pregnancy. METHODS: Ewes with a single fetus (gestational age [GA] 100 days) received an intramuscular injection of 150 mg medroxyprogesterone-acetate, followed by intramuscular (i) betamethasone (0...
April 17, 2018: Neonatology
https://www.readbyqxmd.com/read/29665358/hyperinsulinemic-euglycemic-clamp-over-the-first-year-of-use-of-depot-medroxyprogesterone-acetate-as-a-contraceptive
#11
Vaneska Melhado-Kimura, Gisele Almeida Batista, Aglécio Luiz de Souza, Priscilla de Nazaré Silva Dos Santos, Sarah Monte Alegre, Elizabeth João Pavin, Luis Bahamondes, Arlete Fernandes
OBJECTIVE: The literature lacks data on the use of the gold-standard hyperinsulinemic-euglycemic clamp (HEC) technique for the evaluation of insulin resistance (IR) in depot-medroxyprogesterone acetate (DMPA) users. This study assessed carbohydrate metabolism in non-obese users of DMPA using the HEC technique. STUDY DESIGN: A prospective, non-randomized, comparative study conducted at the Family Planning Clinic/Metabolic Unit, University of Campinas, Brazil. Forty-eight women aged 18-39 years underwent HEC: 30 initiating use of DMPA and 18 initiating use of a copper intrauterine device (IUD)...
April 14, 2018: Contraception
https://www.readbyqxmd.com/read/29658436/thrombin-alters-human-endometrial-stromal-cell-differentiation-during-decidualization
#12
Samir N Babayev, Mohammed Kanchwala, Chao Xing, Yucel Akgul, Bruce R Carr, Ruth Ann Word
Vaginal bleeding and subchorionic hematomas are associated with increased risk of both early and late pregnancy loss. Thrombin generation may play a pivotal role in the development of these complications. To determine the effects of thrombin on human endometrial stromal cells (hESCs), cells were treated with thrombin at baseline or during decidualization with cyclic adenosine monophosphate (cAMP)+medroxyprogesterone acetate (MPA). Next-generation RNA sequencing revealed that markers of decidualization (IGF-1, IGFBP-1, and prolactin [PRL]) were induced after the initiation of decidualization, whereas thrombin suppressed insulin-like growth factor ( IGF)-1, Insulin-like growth factor binding protein ( IGFBP)-1, and PRL gene expression at baseline and during decidualization...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29648595/progesterone-as-a-postnatal-prophylactic-agent-for-encephalopathy-caused-by-prenatal-hypoxic-ischemic-insult
#13
Yoshimasa Kawarai, Hirokazu Tanaka, Tatsuya Kobayashi, Makio Shozu
Brain damage caused by hypoxic ischemic insult during the perinatal period causes hypoxic ischemic encephalopathies (HIEs). Therapeutic hypothermia is indicated for HIE, but since the therapeutic burden is large for its limited therapeutic effectiveness, another strategy is needed. Progesterone (P4) plays a neuroprotective role through the actions of its metabolite, allopregnanolone (Allo), on P4 receptor, GABA (γ-aminobutyric acid)A receptors or both. We examined the therapeutic potential of P4 using a newborn rat model of HIE...
April 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29617576/current-understanding-on-pharmacokinetics-clinical-efficacy-and-safety-of-progestins-for-treating-pain-associated-to-endometriosis
#14
Fabio Barra, Carolina Scala, Simone Ferrero
Introduction Endometriosis is a chronic estrogen and progestogen responsive inflammatory disease associated with pain symptoms and infertility. The medical therapy of endometriosis aims to induce decidualization within the hormonally dependent ectopic endometrium, and it is often administered to ameliorate women' pain symptoms or to prevent post-surgical disease recurrence. A variety of progestins have been used in monotherapy for the medical management of women with endometriosis. Areas covered This review aims to offer the reader a complete overview of pharmacokinetic (PK) and clinical efficacy of progestins for the treatment of endometriosis...
April 4, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29609057/designing-a-global-monitoring-system-for-pilot-introduction-of-a-new-contraceptive-technology-subcutaneous-dmpa-dmpa-sc
#15
Anna Stout, Siri Wood, Allen Namagembe, Alain Kaboré, Daouda Siddo, Ida Ndione
In collaboration with ministries of health, PATH and key partners launched the first pilot introductions of subcutaneous depot medroxyprogesterone acetate (DMPA-SC, brand name Sayana® Press) in Burkina Faso, Niger, Senegal, and Uganda from July 2014 through June 2016. While each country implemented a unique introduction strategy, all agreed to track a set of uniform indicators to chart the effect of introducing this new method across settings. Existing national health information systems (HIS) were unable to track new methods or delivery channels introduced for a pilot, thus were not a feasible source for project data...
March 5, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29602866/expanding-access-to-injectable-contraception-results-from-pilot-introduction-of-subcutaneous-depot-medroxyprogesterone-acetate-dmpa-sc-in-4-african-countries
#16
Anna Stout, Siri Wood, George Barigye, Alain Kaboré, Daouda Siddo, Ida Ndione
PATH partnered with the United Nations Population Fund (UNFPA) and country ministries of health (MOHs) to coordinate pilot introductions of subcutaneous depot medroxyprogesterone acetate (subcutaneous DMPA or DMPA-SC, brand name Sayana Press) in Burkina Faso, Niger, Senegal, and Uganda from July 2014 through June 2016 in order to expand the range of methods available to women, particularly in remote locations. The pilot introductions aimed to answer key questions that would inform decisions about future investments in DMPA-SC and scaling up product availability and service-delivery innovations nationally...
March 21, 2018: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29587706/tb-epidemiology-where-are-the-young-women-know-your-tuberculosis-epidemic-know-your-response
#17
Rubeshan Perumal, Kogieleum Naidoo, Nesri Padayatchi
BACKGROUND: The global predominance of tuberculosis in men has received significant attention. However, epidemiological studies now demonstrate that there is an increased representation of young women with tuberculosis, especially in high HIV burden settings where young women bear a disproportionate burden of HIV. The role of the HIV epidemic, as well as changes in behavioural, biological, and structural risk factors are explored as potential explanations for the increasing burden of tuberculosis in young women...
March 27, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29577272/effect-of-a-tissue-selective-estrogen-complex-tsec-on-breast-cancer-role-of-unique-properties-of-conjugated-equine-estrogen
#18
Wei Yue, Jiping Wang, Kristen A Atkins, Lisa Bottalico, Clementina Mesaros, Ian A Blair, Richard J Santen
The Women's Health Initiative studies reported that the menopausal hormone therapy (MHT) regimen containing conjugated equine estrogen (CEE) and medroxyprogesterone acetate increased, whereas CEE alone reduced breast cancer incidence. These observations suggest the possibility that CEE might exert unique actions on breast and also suggest the need to eliminate the progestogen from MHT regimens. A MHT regimen called a tissue selective estrogen complex (TSEC), containing CEE plus bazedoxifene (BZA), to avoid the need for a progestogen, was developed and FDA approved...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29570359/progestogens-and-venous-thromboembolism-in-menopausal-women-an-updated-oral-versus-transdermal-estrogen-meta-analysis
#19
P-Y Scarabin
Postmenopausal hormone therapy (HT) is a modifiable risk factor for venous thromboembolism (VTE). While the route of estrogen administration is now well recognized as an important determinant of VTE risk, there is also increasing evidence that progestogens may modulate the estrogen-related VTE risk. This review updates previous meta-analyses of VTE risk in HT users, focusing on the route of estrogen administration, hormonal regimen and progestogen type. Among women using estrogen-only preparations, oral but not transdermal preparations increased VTE risk (relative risk (RR) 1...
March 23, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29544204/two-synthetic-progestins-and-natural-progesterone-are-responsible-for-most-of-the-progestagenic-activities-in-municipal-wastewater-treatment-plant-effluents-in-the-czech-and-slovak-republics
#20
Pavel Šauer, Alžběta Stará, Oksana Golovko, Olga Valentová, Adam Bořík, Roman Grabic, Hana Kocour Kroupová
Vast numbers of xenobiotics are known still to be present in treated municipal wastewater treatment plant (WWTP) effluents. Some of these possess endocrine-disrupting potency and pose risks for exposed aquatic animals. We searched for 17 potential environmental contaminants having affinity to the progesterone receptor. Relative potency values of these progesterone receptor-active chemicals were obtained. On the basis of relative potencies and measured environmental concentrations, the contribution of progestins to measured progestagenic activities was evaluated...
June 15, 2018: Water Research
keyword
keyword
22363
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"