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Medroxyprogesterone acetate

Renee Heffron, Urvi M Parikh, Kerri J Penrose, Nelly Mugo, Deborah Donnell, Connie Celum, John W Mellors, Jared M Baeten
Observational analyses have suggested that women using the injectable contraceptive depot medroxyprogesterone acetate (DMPA) may have heightened risk of acquiring HIV. However, those analyses were potentially confounded by sexual behavior, with possible differential condom use and reporting by women using DMPA versus no contraception. In a cross-sectional study, we measured the presence of a biomarker of recent condomless sex (Y chromosomal [Yc] DNA) in vaginal swabs from HIV-uninfected African women who had an HIV-infected partner and reported 100 % condom use...
October 3, 2016: AIDS and Behavior
S-T Oh
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Da Hee Kim, Seok Ju Seong, Mi Kyoung Kim, Hyo Sook Bae, Mi La Kim, Bo Seong Yun, Yong Wook Jung, Jeong Yun Shim
OBJECTIVE: To determine whether less invasive endometrial (EM) aspiration biopsy is adequately accurate for evaluating treatment outcomes compared to the dilatation and curettage (D&C) biopsy in early-stage endometrial cancer (EC) patients treated with high dose oral progestin and levonorgestrel intrauterine system (LNG-IUS). METHODS: We conducted a prospective observational study with patients younger than 40 years who were diagnosed with clinical stage IA, The International Federation of Gynecology and Obstetrics grade 1 or 2 endometrioid adenocarcinoma and sought to maintain their fertility...
August 2, 2016: Journal of Gynecologic Oncology
Zeepee Godha, Zehra Mohsin, Seema Hakim, Saeeda Wasim
PURPOSE: The purpose of this study was to compare the effects of ormeloxifene with medroxyprogesterone acetate in patients with abnormal uterine bleeding. MATERIAL AND METHOD: 440 Patients were divided into two groups. In group A, ormeloxifene was given at the dosage of 60 mg twice a week for 3 months followed by 60 mg once a week for 1 month. In group B, medroxyprogesterone acetate was given at the dosage of 10 mg twice a day from day 5 to day 25 of the menstrual cycle...
October 2016: Journal of Obstetrics and Gynaecology of India
Ai-Jun Sun, Ya-Ping Wang, Bei Gu, Ting-Ping Zheng, Shou-Qing Lin, Wen-Pei Bai, Yang Wei, Shao-Fen Zhang, Ying Zhang
OBJECTIVE: To evaluate the efficacy and safety of Heyan Kuntai Capsule (, HYKT) and hormone therapy (HT) on perimenopausal syndromes (PMSs). METHODS: From 2005 to 2008, 390 women with PMSs were recruited from 4 clinic centers. The inclusion criteria included ages 40 to 60 years, estradiol (E2) below 30 ng/L, and follicle stimulating hormone (FSH) above 40 IU/L, etc. The patients were randomly assigned to HYKT group or HT group by random number table method, administrated HYKT or conjugated estrogen with/without medroxyprogesterone acetate tablets for 12 months...
September 20, 2016: Chinese Journal of Integrative Medicine
Elizabeth G Raymond, Mark A Weaver, Karmen S Louie, Yi-Ling Tan, Manuel Bousiéguez, Ana Gabriela Aranguré-Peraza, Elba M Lugo-Hernández, Patricio Sanhueza, Alisa B Goldberg, Kelly R Culwell, Clair Kaplan, Lisa Memmel, Sarita Sonalkar, Roxanne Jamshidi, Beverly Winikoff
OBJECTIVE: To evaluate the effects of timing of depot medroxyprogesterone acetate injection on medical abortion outcome and risk of repeat pregnancy within the subsequent 6 months. METHODS: In a multinational randomized trial, we assigned women undergoing medical abortion who wanted depot medroxyprogesterone acetate to administration either with mifepristone (Quickstart group) or after the abortion (Afterstart group). We ascertained abortion outcome, pregnancies, and contraception use over 7 months...
October 2016: Obstetrics and Gynecology
Priscilla de Nazaré Silva Dos Santos, Aglécio Luiz de Souza, Gisele Almeida Batista, Vaneska Melhado-Kimura, Gabriel Araújo de Lima, Luis Bahamondes, Arlete Fernandes
PURPOSE: Weight gain has been cited by women as one of the main reasons for discontinuation of the contraceptive depot medroxyprogesterone acetate (DMPA). This study aimed to evaluate binge eating and the biochemical markers of appetite in new DMPA users. METHODS: In this prospective non randomized study with adult healthy women, twenty-eight users of DMPA and twenty-five users of a copper intrauterine device (IUD) were paired for age (±1 year) and body mass index (BMI) (±1 kg/m(2))...
September 7, 2016: Archives of Gynecology and Obstetrics
Gisele Almeida Batista, Aglécio Luiz de Souza, Daniela Miguel Marin, Marina Sider, Vaneska Carvalho Melhado, Arlete Maria Fernandes, Sarah Monte Alegre
Objective: The aim of this study was to evaluate for 12 months the changes of body weight using Depot Medroxyprogesterone Acetate (DMPA) and if these changes are related to inflammatory markers. Subjects and methods: Twenty women of childbearing age who chose the DMPA, without previous use of this method, BMI < 30 kg/m2, and 17 women using IUD TCu 380A, participated in the study. At the baseline and after one year, changes in weight gain, body composition by the bioimpedance electric method, resting energy expenditure (REE) by the indirect calorimetry method, inflammatory markers and HOMA-IR were assessed...
September 5, 2016: Archives of Endocrinology and Metabolism
Martín C Abba, Yi Zhong, Jaeho Lee, Hyunsuk Kil, Yue Lu, Yoko Takata, Melissa S Simper, Sally Gaddis, Jianjun Shen, C Marcelo Aldaz
Controversy always existed on the utility of chemically induced mouse mammary carcinogenesis models as valid equivalents for the study of human breast cancer. Here, we performed whole exome and RNA sequencing on long latency mammary tumors (218 ± 27 days) induced by the carcinogen 7,12-Dimethylbenzathracene (DMBA) and short latency tumors (65 ± 11 days) induced by the progestin Medroxyprogesterone Acetate (MPA) plus DMBA in CD2F1 mice. Long latency tumors displayed a high frequency of Pi3kca and/or Pten mutations detected in 11 of 13 (85%) long latency cases (14/22, 64% overall)...
August 31, 2016: Oncotarget
Laureen M Lopez, Shanthi Ramesh, Mario Chen, Alison Edelman, Conrad Otterness, James Trussell, Frans M Helmerhorst
BACKGROUND: Progestin-only contraceptives (POCs) are appropriate for many women who cannot or should not take estrogen. POCs include injectables, intrauterine contraception, implants, and oral contraceptives. Many POCs are long-acting, cost-effective methods of preventing pregnancy. However, concern about weight gain can deter the initiation of contraceptives and cause early discontinuation among users. OBJECTIVES: The primary objective was to evaluate the association between progestin-only contraceptive use and changes in body weight...
2016: Cochrane Database of Systematic Reviews
Adrienn Csányi, Judit Bóta, George Falkay, Robert Gáspár, Eszter Ducza
Thirteen mammalian aquaporin (AQP) water channels are known, and few of them play a role in the mammalian reproductive system. In our earlier study, the predominance of AQP5 in the late-pregnant rat uterus was proven. Our current aim was to investigate the effect of estrogen- and gestagen-related compounds on the expression of the AQP5 channel in the late-pregnant rat uterus. Furthermore, we examined the effect of hormonally-induced preterm delivery on the expression of AQP5 in the uterus. We treated pregnant Sprague-Dawley rats subcutaneously with 17β-estradiol, clomiphene citrate, tamoxifen citrate, progesterone, levonorgestrel, and medroxyprogesterone acetate...
2016: International Journal of Molecular Sciences
Santiago Palacios, Andrea Mejía
INTRODUCTION: Today, it is a mandatory practice to prescribe a combination of estrogens and progestogens for menopausal women requiring hormone therapy and with a uterus. The WHI study and its reanalysis demonstrate a big difference in results between the conjugated equin estrogen (CEE) only vs.CEE plus medroxyprogesterone acetate (MPA) arms in relation with breast cancer and cardiovascular risk. The conclusion is that risk is clearly higher in the arm with MPA than in the CEE only arm...
August 22, 2016: Expert Opinion on Drug Safety
Meghan A Connolly, Mark Trentalange, Caroline J Zeiss
Depot medroxyprogesterone acetate (DMPA) is a common medical treatment for endometriosis in NHP. Because DMPA reportedly impairs glucoregulatory function in humans and rhesus macaques, as well as predisposes humans to diabetes mellitus (DM), we performed a retrospective study to further investigate its potential long-term clinical effects in animals with and without DM. Using a cohort of 29 rhesus macaques, we explored the hypotheses that DMPA treatment accelerates the onset of DM and that its use in rhesus macaques with endometriosis worsens clinical outcome measures (lifespan, body weight and body condition score)...
2016: Comparative Medicine
Anne Ørbo, Marit Arnes, Lena Myreng Lyså, Christer Borgfelt, Bjørn Straume
BACKGROUND: The aim of the present study was to investigate whether changes in the tissue expression of human epididymis-specific protein 4 (HE4) could predict therapy resistance and relapse after progestin hormone therapy for medium- and low-risk endometrial hyperplasia. METHODS: Endometrial biopsies were obtained from women participating in a multicentre RCT performed according to the CONSORT guidelines; the women were randomly assigned to either LNG-IUS; 10 mg of oral medroxyprogesterone acetate (MPA) administered for 10 days per cycle; or 10 mg of oral MPA administered daily for 6 months...
September 6, 2016: British Journal of Cancer
Laureen M Lopez, Alissa Bernholc, Mario Chen, Thomas W Grey, Conrad Otterness, Carolyn Westhoff, Alison Edelman, Frans M Helmerhorst
BACKGROUND: Obesity has reached epidemic proportions around the world. Effectiveness of hormonal contraceptives may be related to metabolic changes in obesity or to greater body mass or body fat. Hormonal contraceptives include oral contraceptives (OCs), injectables, implants, hormonal intrauterine contraception (IUC), the transdermal patch, and the vaginal ring. Given the prevalence of overweight and obesity, the public health impact of any effect on contraceptive efficacy could be substantial...
2016: Cochrane Database of Systematic Reviews
Jéssica M Ferreira, Bruna F Bottura, Mayara P Gonçalves, Ilza Monteiro, Luis Bahamondes
OBJECTIVES: The aim of this study was to compare the clinical performance of depot medroxyprogesterone acetate (DMPA) in women who received injections every 3 months at the Family Planning Clinic, and those who received every other injection at a health care facility near their place of residence, only returning to the clinic every 6 months. MATERIALS AND METHODS: The medical charts of DMPA users from 2 January 1980 through 31 December 2012 were evaluated for this study...
October 2016: European Journal of Contraception & Reproductive Health Care
W Xue, A J Sun, T P Zheng, J F Jiang, Y P Wang, Y Zhang, F L Chen, Y Deng, Y F Wang
OBJECTIVE: To explore the effects of five different therapy in women at early stage of menopause on menopausal symptoms, quality of Life and cardiovascular risk factors. METHODS: A total of 140 women at early stage of menopause were randomly divided into five groups. Thirty women took Conjugated estrogen and medroxyprogesterone acetate(CEE+ MPA) sequential therapy, 27 women took estradiol valerate and medroxyprogesterone acetate(E2V+ MPA) sequential therapy, 26 women took estradiol valerate and Progesterone Soft Capsules(E2V+ P) sequential therapy, 30 women took Kuntai capsule, and 27 took Cohosh extract...
August 2, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Giovanni Grandi, Michael Mueller, Nick Bersinger, Andrea Papadia, Konstatinos Nirgianakis, Angelo Cagnacci, Brett McKinnon
PROBLEM: Endometriosis is an estrogen-dependent inflammatory disease. Progestins are a first-line treatment for endometriosis via activation of pituitary progesterone receptors and suppression of systemic estrogen: a less than optimal treatment. Increasing evidence is beginning to show that progestins may also influence local endometriotic cells, which may contribute to their clinical efficacy. METHOD OF STUDY: Endometrial stromal cells (ESC) isolated from women with endometriosis were cultured with TNF-α to simulate an inflammatory environment...
October 2016: American Journal of Reproductive Immunology: AJRI
Mark A Espeland, Stephen R Rapp, JoAnn E Manson, Joseph S Goveas, Sally A Shumaker, Kathleen M Hayden, Julie C Weitlauf, Sarah A Gaussoin, Laura D Baker, Claudia B Padula, Lifang Hou, Susan M Resnick
BACKGROUND: Postmenopausal hormone therapy may have long-term effects on cognitive function depending on women's age. METHODS: Postintervention follow-up was conducted with annual cognitive assessments of two randomized controlled clinical trial cohorts, beginning an average of 6-7 years after study medications were terminated: 1,376 women who had enrolled in the Women's Health Initiative when aged 50-54 years and 2,880 who had enrolled when aged 65-79 years. Women had been randomly assigned to 0...
August 9, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Claudia Tosti, Antonella Biscione, Giuseppe Morgante, Giuseppe Bifulco, Stefano Luisi, Felice Petraglia
Endometriotic lesions are associated with hormonal imbalance, including increased estrogen synthesis, metabolism and progesterone resistance. These hormonal changes cause increased proliferation, inflammation, pain and infertility. Hormonal imbalances are targets for treatment. Therapeutic strategies and innovations of hormonal drugs for endometriosis are increasing. Acting on estrogen receptors are hormonal drugs decreasing systemic and local estrogen synthesis (GnRH analogs, GnRH antagonists, Aromatase inhibitors) or estrogen activity (selective estrogen receptor modulators)...
May 27, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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