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Medroxyprogesterone acetate

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https://www.readbyqxmd.com/read/28543978/the-impact-of-the-boxed-warning-on-the-duration-of-use-for-depot-medroxprogesterone-acetate
#1
Efe Eworuke, Joo-Yeon Lee, Lisa Soule, Vaishali Popat, David G Moeny
OBJECTIVE: The objective of this study was to examine the impact of the Food and Drug Administration's boxed warning on the utilization of depot medroxyprogesterone (DMPA). METHODS: From the IMS Lifelink data (2001-2009), we identified DMPA and oral combined hormonal contraceptive (CHC) users without a prescription claim 6 months before and after the first and last claim. Episodes were defined as all contiguous claims with no more than 90-day DMPA or 30-day CHC between claims...
May 23, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28543135/bone-mineral-density-testing-and-bisphosphonate-and-oestrogen-prescribing-associated-with-depot-medroxyprogesterone-acetate-utilization-the-impact-of%C3%A2-the%C3%A2-boxed-warning
#2
E Eworuke, V Popat, D G Moeny
WHAT IS KNOWN AND OBJECTIVE: Depot medroxyprogesterone acetate (DMPA) prevents follicular maturation and ovulation, resulting in oestrogen deficiency. Oestrogen deficiency is particularly concerning as it is associated with decreases in bone mineral density (BMD) or bone mass. Widespread use of concurrent oestrogen or bisphosphonates with DMPA has been observed in a previous single-centre US study. The authors also reported that more than half of obstetrician-gynaecologists ordered BMD testing solely due to DMPA...
May 23, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28542081/dapivirine-vaginal-ring-use-does-not-diminish-the-effectiveness-of-hormonal-contraception
#3
Jennifer E Balkus, Thesla Palanee-Phillips, Krishnaveni Reddy, Samantha Siva, Ishana Harkoo, Clemensia Nakabiito, Kenneth Kintu, Gonasangrie Nair, Catherine Chappell, Flavia Matovu Kiweewa, Samuel Kabwigu, Logashvari Naidoo, Nitesha Jeenarain, Mark Marzinke, Lydia Soto-Torres, Elizabeth R Brown, Jared M Baeten
OBJECTIVE: To evaluate the potential for a clinically relevant drug-drug interaction with concomitant use of a dapivirine vaginal ring, a novel antiretroviral-based HIV-1 prevention strategy, and hormonal contraception by examining contraceptive efficacies with and without dapivirine ring use. DESIGN: A secondary analysis of women participating in MTN-020/ASPIRE, a randomized, double-blind, placebo-controlled trial of the dapivirine vaginal ring for HIV-1 prevention...
May 23, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28540420/allred-score-is-a-promising-predictor-of-prognosis-and-medroxyprogesterone-acetate-efficacy-in-patients-with-endometrial-cancer
#4
Mayu Yunokawa, Hiroshi Yoshida, Reiko Watanabe, Emi Noguchi, Akihiko Shimomura, Tatsunori Shimoi, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara, Kenji Tamura
PURPOSE: Predictors of response or disease control with oral medroxyprogesterone acetate (MPA) therapy in patients with metastatic or recurrence endometrial cancer remain to be elucidated. The purpose of this study was to clarify the effect of MPA in patients with endometrial cancer and identify markers that predict MPA efficacy. METHODS: We retrospectively analyzed clinical and pathological factors in patients who received MPA. Expression of estrogen receptor, progesterone receptor (PgR), androgen receptor, and Ki67 index was assessed with residual tissue samples of endometrial cancer...
May 24, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28522271/medroxyprogesterone-acetate-drives-m2-macrophage-differentiation-toward-a-phenotype-of-decidual-macrophage
#5
Yung-Chieh Tsai, Joseph T Tseng, Chia-Yih Wang, Mei-Tsz Su, Jyun-Yuan Huang, Pao-Lin Kuo
M1 macrophage differentiation plays a crucial role in enhanced inflammation during pregnancy, which may lead to pregnancy complications. Therefore, modulation of macrophage differentiation toward the M2 phenotype is desirable to ensure a successful pregnancy. Medroxyprogesterone acetate (MPA) is a potent progestin with an anti-inflammatory property, but its effect on macrophage differentiation is unknown. This study aimed to examine whether MPA can induce an M2 macrophage differentiation by using the human monocytes cell line THP-1 or primary monocytes...
May 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28516379/panobinostat-enhances-growth-suppressive-effects-of-progestin-on-endometrial-carcinoma-by-increasing-progesterone-receptor-and-mitogen-inducible-gene-6
#6
Hirofumi Ando, Tsutomu Miyamoto, Hiroyasu Kashima, Shotaro Higuchi, Koichi Ida, David Hamisi Mvunta, Tanri Shiozawa
Although progestin has been used to treat endometrial hyperplasia and endometrial carcinoma (EC), its therapeutic efficacy is limited. In order to improve this, the underlining mechanisms of the effects of progestin need to be elucidated in more detail. In the present study, we examined the involvement of mitogen-inducible gene-6 (MIG6), a negative regulator of the EGF receptor, in the progestin-mediated growth suppression of endometrial epithelia. The immunohistochemical expression of MIG6 was elevated in the early to mid-secretory phases of normal endometrium and also with endometrial hyperplasia after medroxyprogesterone acetate (MPA) therapy...
May 17, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28503774/effect-of-the-injectable-contraceptive-depot-medroxyprogesterone-acetate-on-coagulation-parameters-in-new-users
#7
Vaneska Melhado-Kimura, Joyce Maria Annichino Bizzacchi, Susan Kelly Picoli Quaino, Silmara Montalvao, Luis Bahamondes, Arlete Fernandes
AIM: The aim of this study was to assess the effects of the injectable depot-medroxyprogesterone acetate (DMPA) contraceptive on selected blood coagulation parameters in young, healthy new users. METHODS: The prospective study included 39 healthy women aged 20-39 years, with a body mass index (BMI; kg/m(2) ) < 30, who were never users of DMPA, and who opted to use DMPA (21 women) or a copper intrauterine device (IUD; 18 women). The women in the two groups were matched for age (±1 year) and BMI (±1)...
May 15, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28494324/an-unexpected-diagnosis-of-primary-omental-endometrial-stromal-sarcoma-in-a-patient-with-acute-right-abdominal-pain-a-case-report-and-review-of-literature
#8
Vered Buchholz, George Kiroff, Markus Trochsler, Harsh Kanhere
INTRODUCTION: Extrauterine Endometrial Stromal Sarcoma (EESS) is an extremely rare mesenchymal tumour that simulates other pathologies, and therefore poses a diagnostic challenge. This report outlines a case of EESS arising from the greater omentum mimicking a colonic tumour, with review of literature. PRESENTATION OF CASE: A 47-year-old woman, with history of hysterectomy for menorrhagia and hormone replacement therapy (HRT), presented with right sided abdominal pain and localized peritonism...
April 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28485925/occurrence-and-ecotoxicological-effects-of-free-conjugated-and-halogenated-steroids-of-17%C3%AE-hydroxypregnanolone-and-pregnanediol-in-swiss-wastewater-and-surface-water
#9
Kun Zhang, Yanbin Zhao, Karl Fent
Apart from estrogens, the occurrence and ecotoxicity of steroids in the aquatic environment is poorly known. Here we analyzed 33 steroids, including estrogens, androgens, progestins, and glucocorticoids in hospital wastewaters, river water and in municipal wastewater treatment plant (WTP) influents and effluents at different sites in Switzerland. In addition, wastewater from different treatment steps of two WTPs with advanced treatment, such as ozonation or pulverized activated carbon, were analyzed to study the steroid's behavior during treatment...
May 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28480658/effects-of-combination-therapy-of-alendronate-and-hormonal-therapy-on-bone-mineral-density-in-postmenopausal-korean-women-multicenter-randomized-controlled-clinical-trial
#10
Byung Koo Yoon, Dong Yun Lee, Man Chul Park, Soo Hyun Cho, Hyoung Moo Park, Young Min Choi
This study evaluated the effects of combination treatment with alendronate (ALEN) and hormone therapy (HT) on bone mineral density (BMD) in postmenopausal Korean women. This multicenter, randomized, controlled clinical trial enrolled 344 postmenopausal women with low BMD. The women received HT (0.625 mg/day of conjugated equine estrogen and 2.5 mg/day of medroxyprogesterone acetate) alone or in combination with ALEN (10 mg/day) for 1 year. Changes in BMD and biochemical markers of bone turnover were evaluated...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28469407/analytical-method-validation-of-high-performance-liquid-chromatography-and-stability-indicating-study-of-medroxyprogesterone-acetate-intravaginal-sponges
#11
Nidal Batrawi, Shorouq Wahdan, Murad Abualhasan
Medroxyprogesterone acetate is widely used in veterinary medicine as intravaginal dosage for the synchronization of breeding cycle in ewes and goats. The main goal of this study was to develop reverse-phase high-performance liquid chromatography method for the quantification of medroxyprogesterone acetate in veterinary vaginal sponges. A single high-performance liquid chromatography/UV isocratic run was used for the analytical assay of the active ingredient medroxyprogesterone. The chromatographic system consisted of a reverse-phase C18 column as the stationary phase and a mixture of 60% acetonitrile and 40% potassium dihydrogen phosphate buffer as the mobile phase; the pH was adjusted to 5...
2017: Analytical Chemistry Insights
https://www.readbyqxmd.com/read/28460663/histomorphometrics-and-quantitative-unbiased-stereology-in-canine-uteri-treated-with-medroxyprogesterone-acetate
#12
P Salinas, M A Miglino, M Del Sol
This article describes the effects of MPA use on the canine uterus using stereological methods. Entire reproductive tracts were removed from normal healthy canine bitches (Canis lupus familiaris) and grouped as: nulliparous (n = 11), multiparous (n = 11) and MPA-treated (n = 11; nulliparous; two treatments; 5 mg/kg). 1 cm samples were cut from the corpus, horn and uterine tube and fixed in 10% formaldehyde. Sections of each were mounted on slides and stained with hematoxylin-eosin. We assessed the fraction area for components of endometrium and myometrium and VV (volume density) and SV (surface density) of the gland and stroma using the M36 test system provided by the STEPanizer Stereological Tool...
June 2017: Theriogenology
https://www.readbyqxmd.com/read/28437215/contraceptive-use-and-pregnancy-incidence-among-women-participating-in-an-hiv-prevention-trial
#13
Carolyne A Akello, Katherine E Bunge, Clemensia Nakabiito, Brenda G Mirembe, Mary Glenn Fowler, Anupam Mishra, Jeanne Marrazzo, Zvavahera M Chirenje, Connie Celum, Jennifer E Balkus
BACKGROUND: Recent HIV prevention trials required use of effective contraceptive methods to fulfill eligibility for enrollment. We compared pregnancy rates in a subset of participants enrolled in the Microbicide Trials Network protocol (MTN-003), a randomized trial of chemoprophylaxis to prevent HIV acquisition among women aged 18-45 years who initiated depot medroxyprogesterone acetate (DMPA) or combined oral contraceptives (COCs) at enrollment, relative to those already using DMPA or COCs...
February 17, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28433626/thrombin-impairs-human-endometrial-endothelial-angiogenesis-implications-for-progestin-only-contraceptive-induced-abnormal-uterine-bleeding
#14
John P Shapiro, Ozlem Guzeloglu-Kayisli, Umit A Kayisli, Nihan Semerci, S Joseph Huang, Sefa Arlier, Kellie Larsen, Paolo Fadda, Frederick Schatz, Charles J Lockwood
OBJECTIVE: Progestin-only contraceptives induce abnormal uterine bleeding, accompanied by prothrombin leakage from dilated endometrial microvessels and increased thrombin generation by human endometrial stromal cell (HESC)-expressed tissue factor. Initial studies of the thrombin-treated HESC secretome identified elevated levels of cleaved chondroitin sulfate proteoglycan 4 (CSPG4), impairing pericyte-endothelial interactions. Thus, we investigated direct and CSPG4-mediated effects of thrombin in eliciting abnormal uterine bleeding by disrupting endometrial angiogenesis...
April 19, 2017: Contraception
https://www.readbyqxmd.com/read/28416734/the-angiotensin-receptor-blocker-losartan-inhibits-mammary-tumor-development-and-progression-to-invasive-carcinoma
#15
Rhiannon Coulson, Seng H Liew, Angela A Connelly, Nicholas S Yee, Siddhartha Deb, Beena Kumar, Ana C Vargas, Sandra A O'Toole, Adam C Parslow, Ashleigh Poh, Tracy Putoczki, Riley J Morrow, Mariah Alorro, Kyren A Lazarus, Evie F W Yeap, Kelly L Walton, Craig A Harrison, Natalie J Hannan, Amee J George, Colin D Clyne, Matthias Ernst, Andrew M Allen, Ashwini L Chand
Drugs that target the Renin-Angiotensin System (RAS) have recently come into focus for their potential utility as cancer treatments. The use of Angiotensin Receptor Blockers (ARBs) and Angiotensin-Converting Enzyme (ACE) Inhibitors (ACEIs) to manage hypertension in cancer patients is correlated with improved survival outcomes for renal, prostate, breast and small cell lung cancer. Previous studies demonstrate that the Angiotensin Receptor Type I (AT1R) is linked to breast cancer pathogenesis, with unbiased analysis of gene-expression studies identifying significant up-regulation of AGTR1, the gene encoding AT1R in ER+ve/HER2-ve tumors correlating with poor prognosis...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412861/the-association-between-progestins-nuclear-receptors-expression-and-inflammation-in-endometrial-stromal-cells-from-women-with-endometriosis
#16
Giovanni Grandi, Michael D Mueller, Nick A Bersinger, Fabio Facchinetti, Brett D McKinnon
Endometriosis is an inflammatory disease and nuclear receptors play a crucial role in mediating the inflammatory response. In endometrial stromal cells (ESC), nuclear receptors expression can be influenced by the local environment. Progestins are first-line, on-label treatments of endometriosis that may have direct effects on endometriotic lesions through these nuclear receptors. Therefore, we investigated whether there was an association between nuclear receptors expression and the influence of progestins on inflammatory cytokines production in a preliminary, in vitro study with primary cultures...
April 17, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28407854/corrigendum-to-failure-of-a-single-dose-of-medroxyprogesterone-acetate-to-induce-uterine-infertility-in-postnatally-treated-domestic-cats-theriogenology-85-4-2016-718-723
#17
M Lopez Merlo, M Faya, P G Blanco, A Carransa, C Barbeito, C Gobello
No abstract text is available yet for this article.
May 2017: Theriogenology
https://www.readbyqxmd.com/read/28381443/effects-of-injectable-progestogen-contraception-versus-the-copper-intrauterine-device-on-hiv-acquisition-sub-study-of-a-pragmatic-randomised-controlled-trial
#18
G Justus Hofmeyr, Mandisa Singata-Madliki, Theresa A Lawrie, Eduardo Bergel, Marleen Temmerman
BACKGROUND: Evidence from observational studies suggests an increased risk of HIV acquisition among women using depot medroxyprogesterone acetate (DMPA) contraception. METHODS: Within the context of a South African programme to increase women's access to the intrauterine contraceptive device (IUD), we conducted a pragmatic, open-label, parallel-arm, randomised controlled trial (RCT) of the IUD versus injectable progestogen contraception (IPC) at two South African hospitals...
April 5, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28376149/mammographic-density-change-with-estrogen-and-progestin-therapy-and-breast-cancer-risk
#19
Celia Byrne, Giske Ursin, Christopher F Martin, Jennifer D Peck, Elodia B Cole, Donglin Zeng, Eunhee Kim, Martin D Yaffe, Norman F Boyd, Gerardo Heiss, Anne McTiernan, Rowan T Chlebowski, Dorothy S Lane, JoAnn E Manson, Jean Wactawski-Wende, Etta D Pisano
Background: Estrogen plus progestin therapy increases both mammographic density and breast cancer incidence. Whether mammographic density change associated with estrogen plus progestin initiation predicts breast cancer risk is unknown. Methods: We conducted an ancillary nested case-control study within the Women's Health Initiative trial that randomly assigned postmenopausal women to daily conjugated equine estrogen 0.625 mg plus medroxyprogesterone acetate 2...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28363508/risk-factors-associated-with-the-onset-and-progression-of-alzheimer-s-disease-a-systematic-review-of-the-evidence
#20
Mona Hersi, Brittany Irvine, Pallavi Gupta, James Gomes, Nicholas Birkett, Daniel Krewski
A systematic review was conducted to identify risk factors associated with the onset and progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews were eligible for inclusion. Primary studies reporting on non-genetic risk factors associated with neuropathologically or clinically confirmed AD were considered. Eighty one systematic reviews reporting on AD onset and 12 reporting on progression satisfied the eligibility criteria. Four hundred and thirty-two relevant primary studies reporting on onset were identified; however, only those published between 2010 and 2012 (n=65) were included in the qualitative synthesis...
March 28, 2017: Neurotoxicology
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