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Medroxyprogesterone acetate

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https://www.readbyqxmd.com/read/28730844/correlation-between-uterine-artery-doppler-indices-and-menstrual-irregularities-among-levonorgestrel-releasing-intrauterine-system-and-depot-medroxyprogesterone-acetate-users-a-prospective-observational-study
#1
Mohamed Rezk, Alaa Al-Halaby, Mohamed Emarh, Mohamed Shawky
OBJECTIVE: To ascertain whether menstrual irregularities among users of levonorgestrel releasing intrauterine system (LNG-IUS) and depot medroxyprogesterone acetate (DMPA), were associated with changes in uterine artery Doppler indices or not. METHODS: This three-year prospective observational study included 102 women using LNG-IUS and 104 women using DMPA for contraception. Participants were followed at regular intervals over three years with performance of transvaginal ultrasound to measure uterine artery pulsatility index (PI) and resistance index (RI) before starting the method and at six months, 12 months, two and three years thereafter...
July 21, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28715800/the-efficacy-of-dienogest-in-the-treatment-of-simple-endometrial-hyperplasia-without-atypia
#2
Gulsum Uysal, Gokhan Acmaz, Yusuf Madendag, Fulya Cagli, Hatice Akkaya, Ilknur Madendag, Eda Ulku Karakilic
AIM: The aim of the study was to compare the effectiveness of dienogest (DIE), depo medroxyprogesterone 17-acetate (MPA), and micronized progesteron (MP) regimens for treatment of simple endometrial hyperplasia (EH) without atypia. METHODS: One hundred and twenty premenopausal patients aged between 35 and 55, with simple EH without atypia, were offered 3 types of progestins (MPA, MP, and DIE) and were randomized to one of them. After 6 months of treatment, patients were reevaluated...
July 15, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28699905/fkbp51-decreases-cell-proliferation-and-increases-progestin-sensitivity-of-human-endometrial-adenocarcinomas-by-inhibiting-akt
#3
Jing Dong, Yulian Jiao, Wenli Mu, Bingru Lu, Muyun Wei, Linying Sun, Shengnan Hu, Bin Cui, Xiaowen Liu, Zijiang Chen, Yueran Zhao
In this study, we investigated the role of FK506 binding protein 51 (FKBP51) in human endometrial adenocarcinoma progression. Immunohistochemical analysis showed decreased FKBP51 expression in endometrial adenocarcinoma tissues. Moreover, higher FKBP51 expression was observed in the normal secretory phase than in proliferative-phase endometrial tissues. FKBP51-shRNA transfected KLE cells showed high Ser473-phospho Akt with decreased p21 and p27 levels, which promoted S-G2/M phase cell cycle progression and proliferation...
June 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28697589/postpartum-family-planning-missed-opportunities-across-the-continuum-of-care
#4
K T Navodani, P Fonseka, C S Goonewardena
Introduction: Postpartum family planning is defined as the prevention of unintended pregnancies and closely spaced pregnancies during the first 12 months following childbirth. Objectives: To assess the practice of family planning (FP) by postpartum mothers in the Regional Director of Health Services (RDHS) division, Kalutara, Sri Lanka. Methods: A community-based, descriptive, cross sectional study was carried out among mothers, 8 to 12 weeks postpartum, in the RDHS division, Kalutara in 2014...
June 30, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28697043/vasomotor-hot-flashes-and-cardiac-repolarization-a-randomized-placebo-controlled-trial-of-postmenopausal-hormone-therapy
#5
Hanna Lantto, Petri Haapalahti, Matti Viitasalo, Heikki Väänänen, Anssi R A Sovijärvi, Olavi Ylikorkala, Tomi S Mikkola
OBJECTIVE: The aim of the study was to compare the effects of different hormone therapies on cardiac repolarization in recently postmenopausal women with and without hot flashes. METHODS: We recruited 150 healthy women: 72 with and 78 without hot flashes. They were randomized and treated for 6 months with transdermal estradiol (1 mg/day), oral estradiol (OE) alone (2 mg/day) or combined with medroxyprogesterone acetate (MPA; 5 mg/day), or placebo. Cardiac repolarization was assessed by measuring QT intervals, rate-dependence of QT-end interval, and T waves from 24-hour electrocardiographic recording before and during hormone therapy, comprising a total of over 20 million QT-interval measurements...
July 10, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28673645/evaluating-the-feasibility-and-acceptability-of-self-injection-of-subcutaneous-depot-medroxyprogesterone-acetate-dmpa-in-senegal-a-prospective-cohort-study
#6
Jane Cover, Maymouna Ba, Jeanette Lim, Jennifer Kidwell Drake, Bocar M Daff
OBJECTIVES: Expanding contraceptive options through self-injection may improve access and confidentiality. There are few published studies on contraceptive self-injection in sub-Saharan Africa and none in West Africa, a region with high unmet need. This study was performed to assess feasibility of subcutaneous DMPA self-injection in Senegal; objectives were to: 1) measure the proportion of participants who self-injected competently 3months after training; 2) measure the proportion who self-injected on time (defined conservatively as within 7days of reinjection date); and 3) assess acceptability of self-injection...
June 30, 2017: Contraception
https://www.readbyqxmd.com/read/28640224/nomegestrol-acetate-suppresses-human-endometrial-cancer-rl95-2-cells-proliferation-in-vitro-and-in-vivo-possibly-related-to-upregulating-expression-of-sufu-and-wnt7a
#7
A-Ying Ma, Shu-Wu Xie, Jie-Yun Zhou, Yan Zhu
Nomegestrol acetate (NOMAC) has been successfully used for the treatment of some gynecological disorders, and as a combined oral contraceptive with approval in many countries. In this study, we investigated the effects of NOMAC on human endometrial cancer cells in vitro and in vivo. The proliferation of human endometrial cancer cells (RL95-2 and KLE) were assessed using CCK-8 and EdU incorporation assays. Whole-genome cDNA microarray analysis was used to identify the effects of NOMAC on gene expression profiles in RL95-2 cells...
June 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28634970/severe-injection-site-reactions-after-subcutaneous-administration-of-sayana%C3%A2
#8
Annika M Jödicke, Hendrike Dahmke, Beat Damke, Martina Schäublin, Gerd A Kullak-Ublick, Stefan Weiler
PURPOSE: Sayana® was introduced as the first depot medroxyprogesterone acetate-containing contraceptive that is administered via subcutaneous injection. Within 10 months, the Regional Pharmacovigilance Centre (RPVC) Zurich received several anonymous reports of serious local reactions after Sayana® administration. In this retrospective study, individual case safety reports (ICSRs) on local adverse drug reactions (ADRs) related to Sayana® were analysed from the WHO pharmacovigilance database...
June 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28609389/time-to-first-occurrence-of-breast-pain-and-vaginal-bleeding-in-phase-3-trials-of-ce-bza
#9
JoAnn V Pinkerton, Andrew G Bushmakin, Joel Bobula, Joanne Lavenberg, Barry S Komm, Lucy Abraham
OBJECTIVE: In studies of the menopausal therapy, conjugated estrogens/bazedoxifene, breast pain and vaginal bleeding rates were comparable to placebo and lower than conjugated estrogens/medroxyprogesterone acetate (MPA). This post hoc analysis determined median time to occurrence of these events. METHODS: Participants in phase 3 conjugated estrogens/bazedoxifene trials recorded breast pain and vaginal bleeding in daily diaries. Median time to first incident was determined in women taking conjugated estrogens 0...
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28598109/-the-study-of-decitabine-effect-on-the-endometrial-carcinoma-xenografted-in-nude-mice
#10
Ran-Hong Li, Xue-Ping Wang, Hui Liu
OBJECTIVES: To explore the effect of the demethylation drug 5-Aza-CdR on endometrial carcinoma xenografted in nude mice. METHODS: Randomly assigned the mice into decitabine (AZA),cisplatin (DDP),medroxyprogesterone acetate (MPA),AZA+DDP,AZA+MPA,DDP+MPA and model groups (three in each group) after building the models of xenografted tumor by transplanting the HEC-1B cells on nude mice,and dealt them respectively with corresponding drugs (1 μg/g,single or combination) in the experiment groups and normal saline in model group (injected per 3 d,8 injections in total)...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28594755/contraception-insurance-coverage-and-receipt-of-long-acting-reversible-contraception-or-depot-medroxyprogesterone-acetate-on-the-day-of-abortion
#11
Jamie W Krashin, Gretchen S Stuart, Joanne Garrett, Hannah Spector, Amy G Bryant, Samantha Charm, Jessica E Morse
OBJECTIVE: To evaluate whether contraceptive insurance coverage for women who present for an abortion is associated with obtaining long-acting reversible contraception or depot medroxyprogesterone acetate (DMPA) on the day the abortion is completed. METHODS: We conducted a prospective cohort study of women presenting for medical or surgical abortion at a single health center in North Carolina. Eligible women were 18 years or older and fluent in English or Spanish...
June 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28579829/natural-and-synthetic-progestins-enrich-cancer-stem-cell-like-cells-in-hormone-responsive-human-breast-cancer-cell-populations-in-vitro
#12
Sandy Goyette, Yayun Liang, Benford Mafuvadze, Matthew T Cook, Moiz Munir, Salman M Hyder
Clinical trials and studies have shown that combination estrogen/progestin hormone replacement therapy, but not estrogen therapy alone or placebo, increases breast cancer risk in postmenopausal women. Using animal models, we have previously shown that both natural and synthetic progestins (including medroxyprogesterone acetate [MPA], a synthetic progestin used widely in the clinical setting) accelerate the development of breast tumors in vivo and increase their metastasis to lymph nodes. Based on these observations, we have hypothesized that progestin-induced breast cancer tumor growth and metastasis may be mediated by an enrichment of the cancer stem cell (CSC) pool...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28577574/activating-transcription-factor-3-promotes-embryo-attachment-via-up-regulation-of-leukemia-inhibitory-factor-in-vitro
#13
Xi Cheng, Jingyu Liu, Huizhi Shan, Lihua Sun, Chenyang Huang, Qiang Yan, Ruiwei Jiang, Lijun Ding, Yue Jiang, Jianjun Zhou, Guijun Yan, Haixiang Sun
BACKGROUND: A receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understood. Here, we examined activating transcription factor 3 (ATF3) expression in human endometria and the functional effect of ATF3 on embryo attachment in vitro. METHODS: Immunohistochemistry (IHC) was used to assess the ATF3 expression patterns in human endometria...
June 2, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28572622/probing-the-action-of-a-novel-anti-leukaemic-drug-therapy-at-the-single-cell-level-using-modern-vibrational-spectroscopy-techniques
#14
Joanna L Denbigh, David Perez-Guaita, Robbin R Vernooij, Mark J Tobin, Keith R Bambery, Yun Xu, Andrew D Southam, Farhat L Khanim, Mark T Drayson, Nicholas P Lockyer, Royston Goodacre, Bayden R Wood
Acute myeloid leukaemia (AML) is a life threatening cancer for which there is an urgent clinical need for novel therapeutic approaches. A redeployed drug combination of bezafibrate and medroxyprogesterone acetate (BaP) has shown anti-leukaemic activity in vitro and in vivo. Elucidation of the BaP mechanism of action is required in order to understand how to maximise the clinical benefit. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, Synchrotron radiation FTIR (S-FTIR) and Raman microspectroscopy are powerful complementary techniques which were employed to probe the biochemical composition of two AML cell lines in the presence and absence of BaP...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28543978/the-impact-of-the-boxed-warning-on-the-duration-of-use-for-depot-medroxprogesterone-acetate
#15
Efe Eworuke, Joo-Yeon Lee, Lisa Soule, Vaishali Popat, David G Moeny
OBJECTIVE: The objective of this study was to examine the impact of the Food and Drug Administration's boxed warning on the utilization of depot medroxyprogesterone (DMPA). METHODS: From the IMS Lifelink data (2001-2009), we identified DMPA and oral combined hormonal contraceptive (CHC) users without a prescription claim 6 months before and after the first and last claim. Episodes were defined as all contiguous claims with no more than 90-day DMPA or 30-day CHC between claims...
May 23, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28543135/bone-mineral-density-testing-and-bisphosphonate-and-oestrogen-prescribing-associated-with-depot-medroxyprogesterone-acetate-utilization-the-impact-of%C3%A2-the%C3%A2-boxed-warning
#16
E Eworuke, V Popat, D G Moeny
WHAT IS KNOWN AND OBJECTIVE: Depot medroxyprogesterone acetate (DMPA) prevents follicular maturation and ovulation, resulting in oestrogen deficiency. Oestrogen deficiency is particularly concerning as it is associated with decreases in bone mineral density (BMD) or bone mass. Widespread use of concurrent oestrogen or bisphosphonates with DMPA has been observed in a previous single-centre US study. The authors also reported that more than half of obstetrician-gynaecologists ordered BMD testing solely due to DMPA...
May 23, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28542081/dapivirine-vaginal-ring-use-does-not-diminish-the-effectiveness-of-hormonal-contraception
#17
Jennifer E Balkus, Thesla Palanee-Phillips, Krishnaveni Reddy, Samantha Siva, Ishana Harkoo, Clemensia Nakabiito, Kenneth Kintu, Gonasangrie Nair, Catherine Chappell, Flavia Matovu Kiweewa, Samuel Kabwigu, Logashvari Naidoo, Nitesha Jeenarain, Mark Marzinke, Lydia Soto-Torres, Elizabeth R Brown, Jared M Baeten
OBJECTIVE: To evaluate the potential for a clinically relevant drug-drug interaction with concomitant use of a dapivirine vaginal ring, a novel antiretroviral-based HIV-1 prevention strategy, and hormonal contraception by examining contraceptive efficacies with and without dapivirine ring use. DESIGN: A secondary analysis of women participating in MTN-020/ASPIRE, a randomized, double-blind, placebo-controlled trial of the dapivirine vaginal ring for HIV-1 prevention...
May 23, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28540420/allred-score-is-a-promising-predictor-of-prognosis-and-medroxyprogesterone-acetate-efficacy-in-patients-with-endometrial-cancer
#18
Mayu Yunokawa, Hiroshi Yoshida, Reiko Watanabe, Emi Noguchi, Akihiko Shimomura, Tatsunori Shimoi, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara, Kenji Tamura
PURPOSE: Predictors of response or disease control with oral medroxyprogesterone acetate (MPA) therapy in patients with metastatic or recurrence endometrial cancer remain to be elucidated. The purpose of this study was to clarify the effect of MPA in patients with endometrial cancer and identify markers that predict MPA efficacy. METHODS: We retrospectively analyzed clinical and pathological factors in patients who received MPA. Expression of estrogen receptor, progesterone receptor (PgR), androgen receptor, and Ki67 index was assessed with residual tissue samples of endometrial cancer...
July 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28522271/medroxyprogesterone-acetate-drives-m2-macrophage-differentiation-toward-a-phenotype-of-decidual-macrophage
#19
Yung-Chieh Tsai, Joseph T Tseng, Chia-Yih Wang, Mei-Tsz Su, Jyun-Yuan Huang, Pao-Lin Kuo
M1 macrophage differentiation plays a crucial role in enhanced inflammation during pregnancy, which may lead to pregnancy complications. Therefore, modulation of macrophage differentiation toward the M2 phenotype is desirable to ensure a successful pregnancy. Medroxyprogesterone acetate (MPA) is a potent progestin with an anti-inflammatory property, but its effect on macrophage differentiation is unknown. This study aimed to examine whether MPA can induce an M2 macrophage differentiation by using the human monocytes cell line THP-1 or primary monocytes...
May 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28516379/panobinostat-enhances-growth-suppressive-effects-of-progestin-on-endometrial-carcinoma-by-increasing-progesterone-receptor-and-mitogen-inducible-gene-6
#20
Hirofumi Ando, Tsutomu Miyamoto, Hiroyasu Kashima, Shotaro Higuchi, Koichi Ida, David Hamisi Mvunta, Tanri Shiozawa
Although progestin has been used to treat endometrial hyperplasia and endometrial carcinoma (EC), its therapeutic efficacy is limited. In order to improve this, the underlining mechanisms of the effects of progestin need to be elucidated in more detail. In the present study, we examined the involvement of mitogen-inducible gene-6 (MIG6), a negative regulator of the EGF receptor, in the progestin-mediated growth suppression of endometrial epithelia. The immunohistochemical expression of MIG6 was elevated in the early to mid-secretory phases of normal endometrium and also with endometrial hyperplasia after medroxyprogesterone acetate (MPA) therapy...
August 2017: Hormones & Cancer
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