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Medroxyprogesterone acetate

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https://www.readbyqxmd.com/read/27913230/effects-of-combined-oral-contraceptives-depot-medroxyprogesterone-acetate-and-the-levonorgestrel-releasing-intrauterine-system-on-the-vaginal-microbiome
#1
J Paul Brooks, David J Edwards, Diana L Blithe, Jennifer M Fettweis, Myrna G Serrano, Nihar U Sheth, Jerome F Strauss, Gregory A Buck, Kimberly K Jefferson
OBJECTIVES: Prior studies suggest that the composition of the vaginal microbiome may positively or negatively affect susceptibility to sexually transmitted infections (STI) and bacterial vaginosis (BV). Some female hormonal contraceptive methods also appear to positively or negatively influence STI transmission and BV. Therefore changes in the vaginal microbiome that are associated with different contraceptive methods may explain, in part, effects on STI transmission and BV. STUDY DESIGN: We performed a retrospective study of 16S rRNA gene survey data of vaginal samples from a subset of participants from the Human Vaginal Microbiome Project at Virginia Commonwealth University...
November 29, 2016: Contraception
https://www.readbyqxmd.com/read/27911853/recurrence-of-cervical-cancer-and-its-resistance-to-progestin-therapy-in-a-mouse-model
#2
Fabiola F Mehta, Seunghan Baik, Sang-Hyuk Chung
Studies using K14E6/K14E7 transgenic mice expressing E6 and E7 oncoprotein of human papillomavirus type 16 (HPV16) have demonstrated that estrogen (E2) is required for the genesis and growth of cervical cancer. Our prior study using the same mouse model has showed that progestin drug medroxyprogesterone acetate (MPA) promotes regression of primary cervical cancer. In the present study, we use the same transgenic mouse model to determine whether the cancer recurs after MPA therapy. Cervical cancer recurred even if MPA treatment was continued...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27896507/levonorgestrel-releasing-intrauterine-systems-versus-oral-cyclic-medroxyprogesterone-acetate-in-endometrial-hyperplasia-therapy-a-meta-analysis
#3
Jin-Sung Yuk, Jae Yen Song, Jung Hun Lee, Won I Park, Hyeong Sik Ahn, Hyun Jung Kim
BACKGROUND: This study aimed to compare the levonorgestrel-releasing intrauterine system (LNG-IUS) with oral cyclic medroxyprogesterone acetate (MPA) in endometrial hyperplasia therapy using randomized controlled trials (RCTs). METHODS: The study searched MEDLINE, EMBASE, CENTRAL, and other databases. All regression outcomes were calculated for dichotomous outcomes in terms of relative risk (RR) and 95% confidence intervals (CIs) using a Mantel-Haenszel random effects model...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27895740/letrozole-as-second-line-hormonal-treatment-for-recurrent-low-grade-endometrial-stromal-sarcoma-a-case-report-and-review-of-the-literature
#4
Kohei Nakamura, Kentaro Nakayama, Masako Ishikawa, Noriyoshi Ishikawa, Hiroshi Katagiri, Atsuko Katagiri, Tomoka Ishibashi, Emi Sato, Kohji Iida, Razia Sultana, Satoru Kyo
Low-grade endometrial stromal sarcoma (LGESS) is a rare malignancy. The tumor is reportedly responsive to hormonal therapy, most commonly with medroxyprogesterone acetate (MPA), but the effectiveness of aromatase inhibitors for recurrent LGESS remains unclear. The present study reports a case of stage IC LGESS presenting with abnormal uterine bleeding, and also provides a review of the literature. Following a total abdominal hysterectomy and bilateral salpingo-oophorectomy, MPA therapy was initiated; treatment was successful, but discontinued 19 months later due to disruptive side effects...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27865296/cardiovascular-disease-risk-associated-with-the-long-term-use-of-depot-medroxyprogesterone-acetate
#5
Huma Dilshad, Rabia Ismail Yousuf, Mohammad Harris Shoaib, Subia Jamil, Humera Khatoon
BACKGROUND: Depot medroxyprogesterone acetate (DMPA) contraception is widely used all over the world; however, it may lead to a decrease in high-density lipoproteins and an increase in low-density lipoproteins (LDL) and triglycerides. These changes in lipid profile have a direct effect on cardiovascular disease risk. This study has been conducted to investigate the relationship between DMPA use and lipid profile, and the effect of worsening of lipid profile on fasting blood glucose. The objective of the present study is to ascertain the effects of DMPA on lipid profiles and Castelli indices, and to estimate the risk of cardiovascular disease in the women using progesterone-only methods for contraception...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27856803/tubal-patency-during-the-menstrual-cycle-and-during-treatment-with-hormonal-contraceptives-a-pilot-study-in-women
#6
Jeffrey T Jensen, Eva Patil, Jacqueline Seguin, Amy Thurmond
BACKGROUND: Hysterosalpingram (HSG) evaluation of tubal patency is typically performed in the follicular phase, but data to support this timing are lacking. PURPOSE: To determine whether menstrual cycle phase or hormonal treatments affect observation of tubal patency during HSG. MATERIAL AND METHODS: Ten participants underwent repeated HSG examinations: during the follicular and luteal phase of a natural menstrual cycle; 30 days following continuous administration of a combined oral contraceptive (COC); and 30 days after an intramuscular injection of depo medroxyprogesterone (DMPA) acetate...
November 17, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27836505/a-randomized-clinical-trial-on-the-effects-of-progestin-contraception-in-the-genital-tract-of-hiv-infected-and-uninfected-women-in-lilongwe-malawi-addressing-evolving-research-priorities
#7
Athena P Kourtis, Lisa Haddad, Jennifer Tang, Lameck Chinula, Stacey Hurst, Jeffrey Wiener, Sascha Ellington, Julie A E Nelson, Amanda Corbett, Kristina De Paris, Caroline C King, Mina Hosseinipour, Irving F Hoffman, Denise J Jamieson
Hormonal contraception is central in the prevention of unintended pregnancy; however there are concerns that certain methods may increase the risk of HIV acquisition and transmission. Hormonal contraceptives may modify the genital mucosa in several ways, however the mechanisms are incompletely understood. Few studies have examined genital HIV shedding prospectively before and after initiation of hormonal contraception. The effects of hormonal contraception on genital HIV shedding in the setting of antiretroviral therapy (ART) are also unknown...
November 9, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27832675/adolescent-contraception-before-and-after-pregnancy-choices-and-challenges-for-the-future
#8
Anderson Borovac-Pinheiro, Fernanda Garanhani Surita, Aline D'Annibale, Rodolfo de Carvalho Pacagnella, Joao Luiz Pinto E Silva
Objective To determine methods of contraception used by adolescents before and after pregnancy. Methods A cross-sectional study was performed, and data were collected from medical records of all teens in puerperal consultation at the Hospital da Mulher - José Aristodemo Pinotti (Caism), Universidade Estadual de Campinas (CAISM), São Paulo, Brazil, between July 2011 and September 2013. The inclusion criterion was being 10 to 19 years old, and the exclusion criterion was having a first consultation 90 days after childbirth...
November 10, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27829826/evaluate-the-effectiveness-of-conservative-treatment-for-menorrhagia-in-women-who-were-admitted-to-the-shahid-sadoughi-hospital-of-yazd-iran-in-2014-2015
#9
M Karimi-Zarchi, M Zaid Abadinezhad, B Bonyadpour, S Kabyrpour-Ashkezar, A M Abhaji
BACKGROUND AND AIM: Abnormal uterine bleeding is one of the most common debilitating menstrual problems. The first therapeutic strategy for abnormal uterine bleeding is drug treatment. This study was, therefore, designed to determine the efficacy of megestrol, medroxyprogesterone, GnRh agonist, Levonorgestrol IUD and endometrial ablation on bleeding and also to evaluate the side effects of each methods in patients with menorrhagia who were admitted to the Shahid Sadoughi clinic of Yazd University of Medical Sciences...
September 2016: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/27821613/use-of-injectable-hormonal-contraception-and-hsv-2-acquisition-in-a-cohort-of-female-sex-workers-in-vancouver-canada
#10
M Eugenia Socías, Putu Duff, Jean Shoveller, Julio S G Montaner, Paul Nguyen, Gina Ogilvie, Kate Shannon
OBJECTIVES: Increased risk of herpes simplex virus 2 (HSV-2) has been proposed as a possible indirect pathway through which hormonal contraceptives (specifically depot medroxyprogesterone acetate (DMPA)) may increase the risk of HIV acquisition among women. We investigated the effects of DMPA on HSV-2 acquisition among female sex workers. METHODS: Longitudinal data were drawn from a prospective cohort of sex workers in Vancouver, Canada. The primary outcome was HSV-2 seroconversion...
November 7, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27820659/no-increase-in-fractures-after-stopping-hormone-therapy-results-from-the-women-s-health-initiative
#11
Nelson B Watts, Jane A Cauley, Rebecca D Jackson, Andrea Z LaCroix, Cora E Lewis, JoAnn E Manson, Joan Neuner, Lawrence S Phillips, Marcia L Stefanick, Jean Wactawski-Wende, Carolyn Crandall
CONTEXT: The Women's Health Initiative (WHI) hormone therapy (HT) trials showed protection against hip and total fractures but a later observational report suggested loss of benefit and a rebound increased risk after stopping. OBJECTIVE: To examine fractures after discontinuation of HT Design and Setting: Two placebo-controlled randomized trials Patients: 15,187 WHI participants who continued active HT or placebo through the intervention period and did not take HT in the post-intervention period Interventions: Conjugated equine estrogen + medroxyprogesterone acetate (CEE+MPA) in naturally menopausal women and conjugated equine estrogen (CEE) alone in women with prior hysterectomy Main Outcome Measures: Total and hip fractures through 5 years after discontinuation Results: Hip fractures were infrequent (∼2...
November 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27789350/bone-mineral-density-and-weight-changes-in-adolescents-randomized-to-three-doses-of-depot-medroxyprogesterone-acetate
#12
Hannah L H Lange, Brittny E Manos, M David Gothard, Lynette K Rogers, Andrea E Bonny
STUDY OBJECTIVE: To assess the association between medroxyprogesterone acetate exposure and bone mineral density (BMD) loss and weight change in adolescents. DESIGN: 48-week prospective, randomized trial conducted May 2012-April 2014. SETTING: Recruitment occurred in the general community and outpatient clinics in Central Ohio. PARTICIPANTS: Self-referred sample of 34 adolescent females aged 12-21 years initiating depot medroxyprogesterone acetate (DMPA)...
October 24, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27789309/a-prospective-cohort-study-of-the-feasibility-and-acceptability-of-depot-medroxyprogesterone-acetate-administered-subcutaneously-through-self-injection
#13
Jane Cover, Allen Namagembe, Justine Tumusiime, Jeanette Lim, Jennifer Kidwell Drake, Anthony K Mbonye
OBJECTIVES: Evidence on contraceptive self-injection from the United States and similar settings is promising, and the practice may increase access. There are no published studies on the feasibility of contraceptive self-injection in sub-Saharan Africa to date. The purpose of this study was to assess feasibility of subcutaneous depot medroxyprogesterone acetate self-injection in Uganda, with specific objectives to (a) measure the proportion of participants who self-injected competently, (b) measure the proportion who self-injected on time 3 months after training (defined conservatively as within 7 days of their reinjection date) and (c) assess acceptability...
October 24, 2016: Contraception
https://www.readbyqxmd.com/read/27787287/injectable-contraception-updates-and-innovation
#14
Gillian Schivone, Laneta Dorflinger, Vera Halpern
PURPOSE OF REVIEW: Injectable contraception is a highly effective form of birth control that is globally popular. Recent research has focused on ways to make injectables such as depot medroxyprogesterone acetate (DMPA) more accessible and to improve the side-effect profile of injectables. This review will focus on new directions and approaches to the use of injectable contraception. RECENT FINDINGS: Research in the area of injectable contraception has focused on improving access for women through home or self-injection, and also task-shifting and community-based distribution in low-resource areas...
December 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27782765/association-of-postpartum-predischarge-depot-medroxyprogesterone-acetate-with-in-hospital-breastfeeding-initiation
#15
Dinah Chen, Elena Fuell Wysong, Hong Li, Lisa Perriera, Lydia Furman
OBJECTIVE: The primary aim of this study was to examine the association between postpartum predischarge depot-medroxyprogesterone acetate (ppDMPA) and in-hospital breastfeeding initiation, and the secondary exploratory aim was to determine if any racial disparities are associated with ppDMPA receipt or its relationship to breastfeeding initiation. MATERIALS AND METHODS: We conducted a cross-sectional retrospective chart review of maternal and newborn records at a large urban academic medical center...
October 26, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27760942/-ethinylestradiol-following-everolimus-plus-exemestane-was-effective-in-postmenopausal-endocrine-responsive-metastatic-breast-cancer-a-case-report
#16
Aya Matsuoka, Akira Hirano, Akinori Hattori, Kaoru Ogura, Hiroaki Inoue, Hiroko Yukawa, Shiho Sakaguchi, Natsuko Tanaka, Asaka Kodera, Mari Kamimura, Yoshihiko Naritaka, Tadao Shimizu
A 71-year-old woman diagnosed with left breast cancer underwent mastectomy and axillary dissection in 1987. Pathological findings showed invasive ductal carcinoma that was ER and PgR positive and HER2 negative.5 -FU and tamoxifen were administered for 2 years as adjuvant therapy.Bone metastasis was found in 2002, and endocrine therapy was started, using anastrozole, exemestane, letrozole, medroxyprogesterone acetate, and fulvestrant.However, liver, lung, pleural, penetiral, and lymph-node metastases were observed, and the following chemotherapy regimen was administered: CAF, capecitabine, paclitaxel, vinorelbine, gemcitabine, methotrexate plus mitomycin C, and eribulin...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27699594/objective-measurement-of-inaccurate-condom-use-reporting-among-women-using-depot-medroxyprogesterone-acetate-for-contraception
#17
Renee Heffron, Urvi M Parikh, Kerri J Penrose, Nelly Mugo, Deborah Donnell, Connie Celum, John W Mellors, Jared M Baeten
Observational analyses have suggested that women using the injectable contraceptive depot medroxyprogesterone acetate (DMPA) may have heightened risk of acquiring HIV. However, those analyses were potentially confounded by sexual behavior, with possible differential condom use and reporting by women using DMPA versus no contraception. In a cross-sectional study, we measured the presence of a biomarker of recent condomless sex (Y chromosomal [Yc] DNA) in vaginal swabs from HIV-uninfected African women who had an HIV-infected partner and reported 100 % condom use...
October 3, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27678938/the-comparison-between-2mg-dienogest-and-high-dose-medroxyprogesterone-acetate-on-oral-treatment-of-endometriosis
#18
S-T Oh
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27670255/dilatation-and-curettage-is-more-accurate-than-endometrial-aspiration-biopsy-in-early-stage-endometrial-cancer-patients-treated-with-high-dose-oral-progestin-and-levonorgestrel-intrauterine-system
#19
Da Hee Kim, Seok Ju Seong, Mi Kyoung Kim, Hyo Sook Bae, Mi La Kim, Bo Seong Yun, Yong Wook Jung, Jeong Yun Shim
OBJECTIVE: To determine whether less invasive endometrial (EM) aspiration biopsy is adequately accurate for evaluating treatment outcomes compared to the dilatation and curettage (D&C) biopsy in early-stage endometrial cancer (EC) patients treated with high dose oral progestin and levonorgestrel intrauterine system (LNG-IUS). METHODS: We conducted a prospective observational study with patients younger than 40 years who were diagnosed with clinical stage IA, The International Federation of Gynecology and Obstetrics grade 1 or 2 endometrioid adenocarcinoma and sought to maintain their fertility...
August 2, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27651636/comparative-study-of-ormeloxifene-and-medroxyprogesterone-acetate-in-abnormal-uterine-bleeding
#20
Zeepee Godha, Zehra Mohsin, Seema Hakim, Saeeda Wasim
PURPOSE: The purpose of this study was to compare the effects of ormeloxifene with medroxyprogesterone acetate in patients with abnormal uterine bleeding. MATERIAL AND METHOD: 440 Patients were divided into two groups. In group A, ormeloxifene was given at the dosage of 60 mg twice a week for 3 months followed by 60 mg once a week for 1 month. In group B, medroxyprogesterone acetate was given at the dosage of 10 mg twice a day from day 5 to day 25 of the menstrual cycle...
October 2016: Journal of Obstetrics and Gynaecology of India
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