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Medroxyprogesterone acetate

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https://www.readbyqxmd.com/read/29156102/decreasing-trends-in-number-of-depot-medroxyprogesterone-acetate-starters-in-norway-a-cross-sectional-study
#1
Ingvild Roksvaag, Finn Egil Skjeldestad
INTRODUCTION: In this study, we examined changes in depot medroxyprogesterone acetate (DMPA) prescriptions over a time-period when new professions started prescribing, and when the method gained some negative media attention. MATERIAL AND METHODS: The Norwegian Prescription Database provided data on hormonal contraception from 2006 through 2012. We estimated annual number of DMPA users by calculating doses sold per day/1000 women and calculated, for each contraceptive method on annual basis, a proportion of defined daily doses of all hormonal contraceptives in 5-year age groups at reproductive age...
November 20, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29150244/proteomic-analysis-of-follicular-fluid-from-tropically-adapted-goats
#2
Alexandre R Paula Junior, Mauricio F van Tilburg, Marina D P Lobo, Ana C O Monteiro-Moreira, Renato A Moreira, Carlos H S Melo, Joanna M G Souza-Fabjan, Airton A Araújo, Luciana M Melo, Dárcio I A Teixeira, Arlindo A Moura, Vicente J F Freitas
The present study was conducted to characterize the major proteome of ovarian follicular fluid from locally-adapted, "Canindé" goats in the northeast of Brazil. Eight estrous cycling goats received a hormonal treatment consisting of medroxyprogesterone acetate, D-cloprostenol and FSH. Fluid was collected by laparoscopy from small (<3mm), medium (3-4mm) and large (>4mm) follicles and then, proteins were analyzed by 2-D SDS-PAGE and tandem mass spectrometry. Thirty-six proteins were identified in the goat follicular fluid, including albumin, immunoglobulins, ceruloplasmin, complement factor B, alpha-1B-glycoprotein precursor, serotransferrin, complement C3 and serpins, among others...
November 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29133336/psychological-behavioural-and-physiological-effects-of-three-long-acting-reversible-contraception-larc-methods-protocol-for-an-ancillary-study-of-the-echo-randomised-trial
#3
Mandisa Singata-Madliki, G Justus Hofmeyr, Florence Carayon-Lefebvre d'Hellencourt, Theresa Anne Lawrie
INTRODUCTION: This is the protocol for an ancillary study to the multicentre Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial, a three-arm randomised trial comparing the effects of depot medroxyprogesterone acetate (DMPA), the levonorgestrel (LNG) implant and the copper intrauterine device (IUD) on HIV incidence (NCT02550067 pre-results). The ancillary study will compare other non-contraceptive effects of these three long-acting, reversible contraceptions about which there is little existing comparative evidence...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29128586/contraception-pregnancy-and-peripartum-experiences-among-women-with-epilepsy-in-bhutan
#4
Sheliza Halani, Lhab Tshering, Esther Bui, Sarah J Clark, Sara J Grundy, Tandin Pem, Sonam Lhamo, Ugyen Dema, Damber K Nirola, Chencho Dorji, Farrah J Mateen
INTRODUCTION: Reports on the reproductive health of women with epilepsy (WWE) in low- and middle-income countries (LMICs) are limited. Bhutan is a lower income country with a high estimated prevalence of epilepsy and no out-of-pocket payment requirements for health visits or medications. METHODS: We developed a 10-category survey to interview WWE ages 20-59 years in the Kingdom of Bhutan to understand their contraceptive use and peripartum experiences. WWE were recruited from 2016-2017 from an existing epilepsy cohort and their reproductive health data were merged with epilepsy and socioeconomic data obtained from initial clinical evaluations performed between 2014 and 2016...
October 18, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29121428/efficacy-of-medroxyprogesterone-acetate-treatment-and-retreatment-for-atypical-endometrial-hyperplasia-and-endometrial-cancer
#5
Satoshi Tamauchi, Hiroaki Kajiyama, Fumi Utsumi, Shiro Suzuki, Kaoru Niimi, Jun Sakata, Mika Mizuno, Kiyosumi Shibata, Fumitaka Kikkawa
AIM: Medroxyprogesterone acetate (MPA) is used to preserve fertility in patients with Grade 1 endometrial cancer without myometrial invasion (G1EA) and those with atypical endometrial hyperplasia (AEH). However, the efficacy of retreatment with MPA has not been sufficiently established for patients who experience recurrence but wish to retain their fertility. This study aimed to show the effectiveness of MPA treatment and retreatment for AEH and G1EA. METHODS: A total of 39 patients received MPA treatment between 2005 and 2015, including nine with G1EA and 30 with AEH...
November 9, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29113312/fkbp51-decreases-cell-proliferation-and-increases-progestin-sensitivity-of-human-endometrial-adenocarcinomas-by-inhibiting-akt
#6
Jing Dong, Yulian Jiao, Wenli Mu, Bingru Lu, Muyun Wei, Linying Sun, Shengnan Hu, Bin Cui, Xiaowen Liu, Zijiang Chen, Yueran Zhao
In this study, we investigated the role of FK506 binding protein 51 (FKBP51) in human endometrial adenocarcinoma progression. Immunohistochemical analysis showed decreased FKBP51 expression in endometrial adenocarcinoma tissues. Moreover, higher FKBP51 expression was observed in the normal secretory phase than in proliferative-phase endometrial tissues. FKBP51-shRNA transfected KLE cells showed high Ser473-phospho Akt with decreased p21 and p27 levels, which promoted S-G2/M phase cell cycle progression and proliferation...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105931/medroxyprogesterone-acetate-treated-human-primary-endometrial-epithelial-cells-reveal-unique-gene-expression-signature-linked-to-innate-immunity-and-hiv-1-susceptibility
#7
Matthew W Woods, Muhammad Atif Zahoor, Sara Dizzell, Chris P Verschoor, Charu Kaushic
PROBLEM: Medroxyprogesterone acetate (MPA), a progestin-based hormonal contraceptive designed to mimic progesterone, has been linked to increased human immunodeficiency virus (HIV-1) susceptibility. Genital epithelial cells (GECs) form the mucosal lining of the female genital tract (FGT) and provide the first line of protection against HIV-1. The impact of endogenous sex hormones or MPA on the gene expression profile of GECs has not been comprehensively documented. METHOD OF STUDY: Using microarray analysis, we characterized the transcriptional profile of primary endometrial epithelial cells grown in physiological levels of E2, P4, and MPA...
November 6, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29102184/determination-of-progestogens-in-surface-and-waste-water-using-spe-extraction-and-lc-apci-appi-hrps
#8
Oksana Golovko, Pavel Šauer, Ganna Fedorova, Hana Kocour Kroupová, Roman Grabic
The aim of this study was to develop a reliable analytical method for the measurement of 17 selected progestogens in waste water and surface water. Automated whole water solid phase extraction (SPE) was used for sample concentration. Liquid chromatography tandem atmospheric pressure chemical ionization/atmospheric pressure photoionization with hybrid quadrupole/orbital trap mass spectrometry operated in high resolution product scan mode (LC-APCI/APPI-HRPS) was applied for the analyses. The whole-method recoveries ranged from 60% to 140% for all analytes at two different spike levels (5 and 50ng/L) in the studied matrices...
October 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29091478/contraception-and-breastfeeding-at-4-months-postpartum-among-women-intending-to-breastfeed
#9
Alison N Goulding, Kathryn Wouk, Alison M Stuebe
OBJECTIVE: To estimate the association between postpartum contraception and breastfeeding among women intending to breastfeed. METHODS: We analyzed data from the Infant Feeding Practices Study II, a prospective cohort study of U.S. mothers (2005-2007). Among 1,349 women with prenatal intention to breastfeed at least 4 months who reported contraception use 3 months postpartum, we used multivariable logistic regression to estimate odds and predicted probabilities of breastfeeding by contraceptive category...
November 1, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29082908/progestogen-only-injectable-contraceptive-acceptor-prevalence-and-client-experience-at-sagamu-nigeria
#10
Adebayo Adekunle Akadri, Oluseyi Isaiah Odelola
CONTEXT: Progestogen-only injectable contraceptive is a long-lasting contraceptive given at interval of two or 3 months. It is effective, safe and convenient. Menstrual irregularity is a recognised side effect. AIMS: This study aims to determine the acceptor prevalence and clinical experience of women using progestogen-only injectable contraceptive at Olabisi Onabanjo University Teaching Hospital, Sagamu. METHODS: This was a retrospective study of new acceptors of progestogen-only injectable contraceptives between 1 January, 2010, and 31 December, 2014...
July 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29055286/in-defense-of-progesterone-a-review-of-the-literature
#11
Allan Lieberman, Luke Curtis
Context • The medical literature on the use of progesterone in postmenopausal women is often confusing and contradictory. Some physicians implicate natural progesterone in an increase in the risk of breast cancer. The chemical structure of natural progesterone (P4) is quite different from chemically altered, synthetic chemicals called progestins, which results in different actions at the cell level. Objective • The research team intended to review the literature to examine the benefits and safety of natural progesterone and determine whether it can cause an increase or decrease in breast cancer risk...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29049921/estrus-resynchronization-in-ewes-with-unknown-pregnancy-status
#12
Vladinis O Miranda, Fernando C Oliveira, Jenniffer H Dias, Sergio F Vargas Júnior, Karina L Goularte, Manoel F Sá Filho, Ocilon G de Sá Filho, Hernan Baldassarre, Arnaldo D Vieira, Thomaz Lucia, Bernardo G Gasperin
Although fixed-time artificial insemination (FTAI) protocols are available for sheep, estrus resynchronization has not been previously reported. The objectives of this study were to evaluate the effect of estrus resynchronization with exogenous progestogen on endogenous progesterone levels and to compare pregnancy rates after two consecutive estrus synchronizations in ewes. In Experiment 1, ewes (n = 20) received an intravaginal device (IVD) containing 60 mg medroxyprogesterone acetate (MPA) for 10 days...
October 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/29039146/estrogen-based-hormone-therapy-in-women-with-primary-ovarian-insufficiency-a-systematic-review
#13
Nydia Burgos, Dahima Cintron, Paula Latortue-Albino, Valentina Serrano, Rene Rodriguez Gutierrez, Stephanie Faubion, Gabriela Spencer-Bonilla, Patricia J Erwin, Mohammad Hassan Murad
PURPOSE: Sex hormones play a role in bone density, cardiovascular health, and wellbeing throughout reproductive lifespan. Women with primary ovarian insufficiency (POI) have lower estrogen levels requiring hormone therapy (HT) to manage symptoms and to protect against adverse long-term health outcomes. Yet, the effectiveness of HT in preventing adverse outcomes has not been systematically assessed. We summarize the evidence regarding effects of HT on bone and cardiovascular health in women with POI...
October 16, 2017: Endocrine
https://www.readbyqxmd.com/read/29031924/evaluation-of-cervical-mucus-and-reproductive-efficiency-of-seasonally-anovular-dairy-goats-after-short-term-progestagen-based-estrous-induction-protocols-with-different-gonadotropins
#14
Jeferson F Fonseca, Joanna M G Souza-Fabjan, Maria Emilia F Oliveira, Renata C Cruz, Luciana V Esteves, Maria Pia S L Matos de Paiva, Felipe Z Brandão, Antônio B Mancio
The use of three different gonadotropins was tested for estrous induction in dairy goats during the non-breeding season. All does received an injection of 30 μg of d-cloprostenol and intravaginal sponges containing 60mg of medroxyprogesterone acetate (MAP) for 6 d plus 20 IU of porcine FSH (pFSH), 200 IU of eCG or 250 IU of hCG 24h before sponge removal. In Experiment 1 (n=24), ovarian ultrasound parameters were recorded and cervical mucus was evaluated daily for 5 d after sponge removal or until ovulation...
October 11, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29031893/in-an-in%C3%A2-vitro-model-using-human-fetal-membranes-17-alpha-hydroxyprogesterone-caproate-is-not-an-optimal-progestogen-for-inhibition-of-fetal-membrane-weakening
#15
Deepak Kumar, Robert M Moore, Brian M Mercer, Joseph M Mansour, Sam Mesiano, Frederick Schatz, Charles J Lockwood, John J Moore
BACKGROUND: The progestogen 17-alpha hydroxyprogesterone caproate is 1 of only 2 agents recommended for clinical use in the prevention of spontaneous preterm delivery, and studies of its efficacy have been conflicting. We have developed an in vitro model to study the fetal membrane weakening process that leads to rupture in preterm premature rupture of the fetal membranes. Inflammation/infection associated with tumor necrosis factor-alpha induction and decidual bleeding/abruption associated thrombin release are leading causes of preterm premature rupture of the fetal membranes...
October 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28966052/misreporting-of-contraceptive-hormone-use-in-clinical-research-participants
#16
Sharon L Achilles, Felix G Mhlanga, Petina Musara, Samuel M Poloyac, Zvavahera M Chirenje, Sharon L Hillier
OBJECTIVE: Researchers traditionally rely on participant self-report for contraceptive use. We hypothesized that self-reported contraceptive use by clinical research participants may disagree with objectively measured hormonal status. STUDY DESIGN: We enrolled women in Harare, Zimbabwe, aged 18-34, who by self-report had not used hormonal or intrauterine contraception for >30 days, or depot medroxyprogesterone acetate for >10 months, into a study designed to assess biologic changes with contraceptive initiation and use...
September 28, 2017: Contraception
https://www.readbyqxmd.com/read/28952325/why-didn-t-you-text-me-poststudy-trends-from-the-depotext-trial
#17
Cara R Muñoz Buchanan, Kathy Tomaszewski, Shang-En Chung, Krishna K Upadhya, Alexandra Ramsey, Maria E Trent
OBJECTIVE: To evaluate the longitudinal impact of a 9-month text message intervention on participant adherence beyond the intervention to highly effective contraceptive methods among urban adolescent and young adult women enrolled in the DepoText randomized control trial (RCT). STUDY DESIGN: Retrospective longitudinal cohort study of long-term follow-up data from the DepoText RCT. Sixty-seven female participants (aged 13-21 years) using depot medroxyprogesterone acetate (DMPA) were recruited from an urban academic adolescent practice in Baltimore, Maryland...
February 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28948397/neonatal-outcomes-and-congenital-malformations-in-children-born-after-human-menopausal-gonadotropin-and-medroxyprogesterone-acetate-treatment-cycles
#18
Jie Zhang, Xiaoyan Mao, Yun Wang, Qiuju Chen, Xuefeng Lu, Qingqing Hong, Yanping Kuang
PURPOSE: To investigate neonatal outcomes and congenital malformations in children born after in vitro fertilization (IVF) and vitrified embryo transfer cycles using human menopausal gonadotrophin and medroxyprogesterone acetate (hMG + MPA) treatment. METHODS: We performed a retrospective cohort study including 4596 live born babies. During January 2014-June 2016, children born after either hMG + MPA treatment, gonadotropin releasing hormone agonist short protocol, or mild ovarian stimulation were included...
December 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28938710/hormone-therapy-use-and-risk-of-chronic-disease-in-the-nurses-health-study-a-comparative-analysis-with-the-women-s-health-initiative
#19
COMPARATIVE STUDY
Shilpa N Bhupathiraju, Francine Grodstein, Bernard A Rosner, Meir J Stampfer, Frank B Hu, Walter C Willett, JoAnn E Manson
Observational studies and randomized controlled trials of menopausal hormone therapy (HT) and chronic disease risk appear to have divergent results for cardiovascular disease. However, differences may be related to a modifying effect of age, time since menopause, and HT formulation. In the Nurses' Health Study (NHS) (enrolling during 1980-1994 and following participants until 2002), we investigated associations between the use of oral conjugated equine estrogens (CEE) (0.625 mg/day) plus medroxyprogesterone acetate (MPA) (<10 mg/day) or oral CEE alone and cardiovascular disease, cancer, all-cause mortality, and other major endpoints among postmenopausal women, aged 50-79 years at HT initiation...
September 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28938437/progressive-fibrosis-a-progesterone-and-klf11-mediated-sexually-dimorphic-female-response
#20
Chandra C Shenoy, Zaraq Khan, Ye Zheng, Tiffanny L Jones, Khashayarsha Khazaie, Gaurang S Daftary
Progressive scarring is ubiquitous postoperatively and in an array of chronic systemic diseases. Recent studies indicate that such scarring has a high female propensity; females are also almost exclusively affected by endometriosis, a common sex steroid-dependent fibrotic disease. Endometriosis-related fibrosis is regulated epigenetically through transcription factor Krüppel-like factor 11 (KLF11). In response to surgical induction of endometriosis, Klf11-/- female mice develop significant fibrosis in contrast to wild-type mice...
October 1, 2017: Endocrinology
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