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Hormone treatments and effects on endometrium

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https://www.readbyqxmd.com/read/29755593/effect-of-stem-cell-transplantation-of-premature-ovarian-failure-in-animal-models-and-patients-a-meta-analysis-and-case-report
#1
Lei Chen, Shilei Guo, Cui Wei, Honglan Li, Haiya Wang, Yan Xu
Stem cell transplantation has been considered a promising therapeutic approach for premature ovarian failure (POF). However, to date, no quantitative data analysis of stem cell therapy for POF has been performed. Therefore, the present study performed a meta-analysis to assess the efficacy of stem cell transplantation in improving ovarian function in animal models of POF. In addition, a case report of a patient with POF subjected to stem cell treatment was included to demonstrate that stem cell therapy also contributes to the recovery of ovarian function in patients...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29673660/comparison-of-antagonist-mild-and-long-agonist-protocols-in-terms-of-follicular-fluid-total-antioxidant-capacity
#2
Begum Aydogan Mathyk, Berna Aslan Cetin, Duygu Vardagli, Emel Zengin, Nigar Sofiyeva, Tulay Irez, Pelin Ocal
OBJECTIVE: A high dose of prolonged gonadotropins can yield higher numbers of oocytes and embryos. The high dose or prolonged regimens can be associated with ovarian hyperstimulation syndrome (OHSS), multiple gestations, emotional stress, economical burden and treatment dropout. In mild stimulation lower doses and shorter duration times of gonadotropin are used in contrast to the conventional long stimulation protocol in IVF. It has been proposed that supraphysiologic levels of hormones may adversely affect endometrium and oocyte/embryo...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29617576/current-understanding-on-pharmacokinetics-clinical-efficacy-and-safety-of-progestins-for-treating-pain-associated-to-endometriosis
#3
Fabio Barra, Carolina Scala, Simone Ferrero
Introduction Endometriosis is a chronic estrogen and progestogen responsive inflammatory disease associated with pain symptoms and infertility. The medical therapy of endometriosis aims to induce decidualization within the hormonally dependent ectopic endometrium, and it is often administered to ameliorate women' pain symptoms or to prevent post-surgical disease recurrence. A variety of progestins have been used in monotherapy for the medical management of women with endometriosis. Areas covered This review aims to offer the reader a complete overview of pharmacokinetic (PK) and clinical efficacy of progestins for the treatment of endometriosis...
April 4, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29579710/bu-shen-zhu-yun-decoction-promotes-synthesis-and-secretion-of-fsh%C3%AE-and-lh%C3%AE-in-anterior-pituitary-cells-in-vitro
#4
Xiaofei Jiang, Huifang Zhou, Mingqing Shi, Boru Zhou, Bei Liu, Yizhen Yuan, Jinjun Shan, Jianya Xu, Tong Xie
Luteal phase defects (LPD) are an important etiology of infertility which has increased in recent years. Studies have shown that bu-shen-zhu-yun decoction (BSZY-D) can lower the expression of estrogen receptor and progesterone receptor, in rats endometrium of embryonic implantation period, which upregulated by mifepristone, and improve uterine receptivity. The aim of present study was to determine the effect of BSZY-D on the synthesis and secretion of gonadotropic hormones in the anterior pituitary cells of rats...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29533367/tissue-selective-estrogen-complex-tsec-a-review
#5
James H Pickar, Matthieu Boucher, Diana Morgenstern
OBJECTIVE: This review describes historical development of selective estrogen receptor modulators (SERMs) and their combination with estrogens, termed a tissue selective estrogen complex (TSEC), and considers the potential for future TSEC development. METHODS: This narrative review is based on literature identified on PubMed and the TSEC research and development experience of the authors. RESULTS: SERMs have estrogenic and antiestrogenic effects in various tissues; however, no single agent has achieved an optimal balance of agonist and antagonist effects for the treatment of menopausal symptoms...
March 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29514724/oestrogen-progesterone-and-stem-cells-the-discordant-trio-in-endometriosis
#6
Chithra Janardhanan Susheelamma, Sathy M Pillai, Sivakumari Asha Nair
Oestrogen-progesterone signalling is highly versatile and critical for the maintenance of healthy endometrium in humans. The genomic and nongenomic signalling cascades initiated by these hormones in differentiated cells of endometrium have been the primary focus of research since 1920s. However, last decade of research has shown a significant role of stem cells in the maintenance of a healthy endometrium and the modulatory effects of hormones on these cells. Endometriosis, the growth of endometrium outside the uterus, is very common in infertile patients and the elusiveness in understanding of disease pathology causes hindrance in selection of treatment approaches to enhance fertility...
March 8, 2018: Expert Reviews in Molecular Medicine
https://www.readbyqxmd.com/read/29482664/human-mesenchymal-stem-cells-in-spheroids-improve-fertility-in-model-animals-with-damaged-endometrium
#7
Alisa Domnina, Polina Novikova, Julia Obidina, Irina Fridlyanskaya, Larisa Alekseenko, Irina Kozhukharova, Olga Lyublinskaya, Valeriy Zenin, Nikolay Nikolsky
BACKGROUND: Asherman's syndrome (AS) is one of the gynecological disorders caused by the destruction of the endometrium. For some cases of AS available surgical methods and hormonal therapy are ineffective. Stem cell transplantation may offer a potential alternative for AS cure. METHODS: Human endometrial mesenchymal stem cells (eMSC) organized in spheroids were transplanted in rats with damaged endometrium modeled on AS. Treatment response was defined as pregnancy outcome and litter size...
February 26, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29430156/effect-of-endometrial-cavity-fluid-on-pregnancy-rate-of-fresh-versus-frozen-in-vitro-fertilization-cycle
#8
Nitika Gupta, Shilpa Bhandari, Pallavi Agrawal, Ishita Ganguly, Aparna Singh
Objective: This study aims to study the difference in etiology and outcome in terms of implantation rate and abortion rate in fresh (self-stimulated) versus frozen (oocyte donation cycle) in vitro fertilization (IVF) and in transient versus persistent fluid. Material and Methods: This retrospective study was conducted in the Department of Reproductive Medicine of tertiary care center from January 2012 to November 2015. Data were collected retrospectively from the departmental files...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29408993/effects-of-histone-methyltransferase-inhibition-in-endometriosis
#9
Mariano Colón-Caraballo, Annelyn Torres-Reverón, John Lee Soto-Vargas, Steven Young, Bruce Lessey, Adalberto Mendoza, Raúl Urrutia, Idhaliz Flores
Although the histone methyltransferase EZH2 and its product H3K27me3 are well studied in cancer, little is known about their role and potential as therapeutic targets in endometriosis. We have previously reported that endometriotic lesions are characterized by global enrichment of H3K27me3. Therefore, we aimed to 1) characterize the expression levels of EZH2 in endometriotic tissues, 2) assess H3K27me3 enrichment in candidate genes promoter regions, and 3) determine if pharmacological inhibition of EZH2 impacts migration, proliferation, and invasion of endometriotic cells...
February 2, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29346527/progesterone-effects-on-extracellular-vesicles-in-the-sheep-uterus
#10
Gregory W Burns, Kelsey E Brooks, Eleanore V O'Neil, Darren E Hagen, Susanta K Behura, Thomas E Spencer
Progesterone (P4) acts via the endometrium to promote conceptus growth and implantation for pregnancy establishment. Many cells release extracellular vesicles (EVs) that are membrane-bound vesicles of endosomal and plasma membrane origin. In sheep, endometrial-derived EVs were found to traffic to the conceptus trophectoderm. Thus, EVs are hypothesized to be an important mode of intercellular communication by transferring select RNAs, proteins, and lipids between the endometrium and conceptus. Electron microscopy analysis found that the endometrial luminal and glandular epithelia were the primary source of EVs in the uterus of cyclic sheep...
January 16, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29345445/the-impact-of-high-progesterone-levels-on-the-day-of-hcg-administration-in-assisted-human-reproduction-treatments
#11
Michelli S Tanada, Ivan H Yoshida, Monise Santos, Caroline Z Berton, Elen Souto, Waldemar P de Carvalho, Emerson B Cordts, Caio P Barbosa
OBJECTIVE: Progesterone is a steroid hormone that acts on the endometrium. It is known for producing physical and mood-related side effects. Few studies have looked into how progesterone levels affect embryo development and quality. This study aimed to find a cutoff level for serum progesterone on the day of HCG administration from which embryo quality is impaired. METHODS: The study included 145 cycles, from which 885 oocytes and 613 embryos were obtained. All patients had their serum progesterone levels measured on the day of HCG administration...
January 18, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29315421/development-of-a-new-comprehensive-and-reliable-endometrial-receptivity-map-er-map-er-grade-based-on-rt-qpcr-gene-expression-analysis
#12
M Enciso, J P Carrascosa, J Sarasa, P A Martínez-Ortiz, S Munné, J A Horcajadas, J Aizpurua
STUDY QUESTION: Is it possible to determine the receptivity status of an endometrium by combined quantitative reverse transcription PCR (RT-qPCR) expression analysis of genes involved in endometrial proliferation and immunity? SUMMARY ANSWER: The new ER Map®/ER Grade® test can predict endometrial receptivity status by RT-qPCR using a new panel of genes involved in endometrial proliferation and the maternal immune response associated to embryonic implantation. WHAT IS KNOWN ALREADY: The human endometrium reaches a receptive status adequate for embryonic implantation around Days 19-21 of the menstrual cycle...
February 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29259469/effects-of-endometrial-injury-on-frozen-thawed-blastocyst-transfer-in-hormone-replacement-cycles
#13
Yukiko Matsumoto, Shoji Kokeguchi, Masahide Shiotani
Aim: To evaluate whether local endometrial injury would improve the pregnancy rates after frozen-thawed blastocyst transfer in cycles with hormone replacement. Methods: Seventy-seven patients who were aged <40 years with a history of at least three unsuccessful embryo transfers and who underwent frozen-thawed blastocyst transfer during hormone replacement cycles between February and June, 2013 were studied. They were allocated into two groups based on the last digit of their clinical record number: an experimental group (n=22), excluding patients who withheld consent or who were unable to undergo treatment, and a control group (n=55)...
April 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29221723/effects-of-thyroxine-on-expression-of-proteins-related-to-thyroid-hormone-functions-tr-%C3%AE-tr-%C3%AE-rxr-and-erk1-2-in-uterus-during-peri-implantation-period
#14
Abu Sadat Md Sayem, Nelli Giribabu, Sekaran Muniandy, Naguib Salleh
INTRODUCTION: Thyroid hormone is known to play important role during embryo implantation, however mechanisms underlying its actions in uterus during peri-implantation period has not been fully identified. In this study, we hypothesized that thyroid hormone could affect expression of proteins related to its function, where these could explain mechanisms for its action in uterus during this period. METHODS: Female rats, once rendered hypothyroid via oral administration of methimazole (0...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29206294/hormone-regulates-endometrial-function-via-cooperation-of-endoplasmic-reticulum-stress-and-mtor-autophagy
#15
Diqi Yang, Tingting Jiang, Jianguo Liu, Jin Hong, Pengfei Lin, Huatao Chen, Dong Zhou, Keqiong Tang, Aihua Wang, Yaping Jin
In ruminant, the receptive endometrium and the elongation of the hatched blastocyst are required to complete the process of implantation. However, the mechanisms regulating goat endometrial function during the peri-implantation period of pregnancy are still unclear. In this study, EECs were treated with progesterone, estradiol and interferon-tau (IFNT). We have found that endoplasmic reticulum (ER) stress were activated under hormones treatment. To identify the cellular mechanism of regulation of endometrial function, we investigated the effect of ER stress activator thapsigargin (TG) and inhibitor 4 phenyl butyric acid (4-PBA) on EECs...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29162648/biological-age-of-the-endometrium-using-dna-methylation
#16
Mia S Olesen, Anna Starnawska, Jonas Bybjerg-Grauholm, Alexandra P Bielfeld, Inge Agerholm, Axel Forman, Michael T Overgaard, Mette Nyegaard
Age has a detrimental effect on reproduction and as an increasing number of women postpone motherhood, it is imperative to assess biological age in terms of fertility prognosis and optimizing fertility treatment individually. Horvath's epigenetic clock is a mathematical algorithm that calculates the biological age of human cells, tissues or organs based on DNA methylation levels. The clock, however, was previously shown to be highly inaccurate for the human endometrium, most likely because of the hormonal responsive nature of this tissue...
February 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29043703/the-effects-of-dienogest-on-macrophage-and-natural-killer-cells-in-adenomyosis-a-randomized-controlled-study
#17
Saowapak Prathoomthong, Yada Tingthanatikul, Srithean Lertvikool, Nittaya Rodratn, Wanwisa Waiyaput, Kanthanadon Dittharot, Morakot Sroyraya, Areepan Sophonsritsuk
Background: Progestin has been used for symptomatic treatment of adenomyosis, although its effect on the immune system has not been studied. The aim of this study was to investigate the changes of macrophage and natural killer (NK) cell infiltration in tissues obtained from women with adenomyosis who did or did not receive oral progestin dienogest. MATERIALS AND METHODS: In this randomized controlled clinical trial study, 24 patients with adenomyosis who required hysterectomy were enrolled...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29043003/tiaogeng-yijing-decoction-improves-the-pregnancy-outcomes-of-patients-with-poor-ovarian-response-undergoing-in-vitro-fertilization-embryo-transfer
#18
Hui Xue, Juan Dong, Huijun Xu, Xin Huang, Huangguan Dai, Cuifang Hao
The present study aimed to explore the therapeutic effects of the Tiaogeng Yijing decoction on patients with poor ovarian response (POR) undergoing in vitro fertilization-embryo transfer (IVF-ET), in addition to the underlying molecular mechanisms of these effects. A total of 40 patients were randomly and equally assigned to the treatment or control group. Patients in the treatment group received the Tiaogeng Yijing decoction continuously for three menstrual cycles in addition to microstimulation, while patients in the control group underwent microstimulation only...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28938896/effect-of-local-endometrial-injury-in-proliferative-vs-luteal-phase-on-ivf-outcomes-in-unselected-subfertile-women-undergoing-in-vitro-fertilization
#19
Wenjie Liu, Reshef Tal, He Chao, Minghui Liu, Ying Liu
BACKGROUND: Mechanical endometrial injury prior to IVF has been suggested as a means to increase implantation rates by improving endometrial receptivity. However, the effects of endometrial injury in proliferative vs. luteal phase have not been studied before. This study aimed to explore whether endometrial injury in the proliferative phase of the preceding cycle before in vitro fertilization/embryo transfer (IVF-ET) improves the clinical outcomes in unselected subfertile women compared with injury in luteal phase...
September 22, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28920404/effects-of-zearalenone-on-the-localization-and-expression-of-the-growth-hormone-receptor-gene-in-the-uteri-of-post-weaning-piglets
#20
Min Zhou, Li Jie Yang, Wei Ren Yang, Li Bo Huang, Xue Mei Zhou, Shu Zhen Jiang, Zai Bin Yang
OBJECTIVE: In this study, we investigated the adverse effects of dietary zearalenone (ZEA) (0.5 to 1.5 mg/kg diet) on the localization and expression of the growth hormone receptor (GHR) in the uteri of post-weaning gilts and explored alternative mechanism of the reproductive toxicity of ZEA on piglets. METHODS: A total of forty healthy piglets (Duroc×Landrace×Large White) aged 28 d were selected for study. Piglets were transferred to single cages after 10 days' adaptation on an obstetric table...
January 2018: Asian-Australasian Journal of Animal Sciences
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