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Hormone treatments and effects on endometrium

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https://www.readbyqxmd.com/read/28407578/a-peek-into-the-drug-development-scenario-of-endometriosis-a-systematic-review
#1
REVIEW
Luxitaa Goenka, Melvin George, Maitrayee Sen
PURPOSE AND OBJECTIVE: Endometriosis is a gynaecological disease that is characterised by the presence of endometrium like tissue-epithelium and stroma that develops outside the uterine cavity, which is responsible for pelvic pain and infertility. Even though several medical therapies exist for the treatment of endometriosis, each of the drug class has its own limitations such as cost of treatment, side-effects and its short-term effect on the symptoms of endometriosis. In this review, we have attempted to summarize the current status and challenges of drug development for endometriosis...
April 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28379469/in-vivo-intrabursal-administration-of-bioactive-lipid-sphingosine-1-phosphate-enhances-vascular-integrity-in-a-rat-model-of-ovarian-hyperstimulation-syndrome-ohss
#2
Mariana Di Pietro, Natalia Pascuali, Leopoldina Scotti, Griselda Irusta, Diana Bas, María May, Marta Tesone, Dalhia Abramovich, Fernanda Parborell
STUDY QUESTION: Can the bioactive lipid sphingosine-1 phosphate (S1P) act as an endothelial barrier-enhancing molecule and, in turn, restore the vascular integrity and homeostasis in a rat model of ovarian hyperstimulation syndrome (OHSS). STUDY ANSWER: In vivo administration of S1P may prevent the early onset of OHSS and decrease its severity. WHAT IS KNOWN ALREADY: Although advances in the prediction and treatment of OHSS have been made, complete prevention has not been possible yet...
April 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28367163/therapeutic-effects-of-metformin-and-clomiphene-in-combination-with-lifestyle-intervention-on-infertility-in-women-with-obese-polycystic-ovary-syndrome
#3
Jing Zhang, Qinqin Si, Jinqiong Li
OBJECTIVE: To evaluate the therapeutic effects of metformin and clomiphene in combination with lifestyle adjustment on infertility in women with obese polycystic ovarian syndrome (PCOS). METHODS: A total of 101 infertile women with obese PCOS admitted to our hospital from July 2013 to July 2015 were randomly divided into an observation group (n=51) and a control group (n=50). The control group was treated with metformin plus clomiphene, based on which the observation group was also subjected to lifestyle adjustment...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28349511/risk-of-endometrial-cancer-in-women-treated-with-ovary-stimulating-drugs-for-subfertility
#4
REVIEW
Alkistis Skalkidou, Theodoros N Sergentanis, Spyros P Gialamas, Marios K Georgakis, Theodora Psaltopoulou, Marialena Trivella, Charalampos S Siristatidis, Evangelos Evangelou, Eleni Petridou
BACKGROUND: Medical treatment for subfertility principally involves the use of ovary-stimulating agents, including selective oestrogen receptor modulators (SERMs), such as clomiphene citrate, gonadotropins, gonadotropin-releasing hormone (GnRH) agonists and antagonists, as well as human chorionic gonadotropin. Ovary-stimulating drugs may act directly or indirectly upon the endometrium (lining of the womb). Nulliparity and some causes of subfertility are recognized as risk factors for endometrial cancer...
March 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28345485/the-effect-of-tamoxifen-on-thin-endometrium-in-patients-undergoing-frozen-thawed-embryo-transfer
#5
Hanni Ke, Jingjing Jiang, Mingdi Xia, Rong Tang, Yingying Qin, Zi-Jiang Chen
Tamoxifen has played a vital role in endocrine therapy for the treatment of estrogen receptor-positive breast cancer. We examined the effect of tamoxifen in patients with a thin endometrium in frozen-thawed embryo transfer (FET) cycles and compared the improvement in endometrial thickness (EMT) and pregnancy outcomes stratified by different etiologies of thin endometrium. A total of 226 women were recruited for a new tamoxifen protocol; all had an EMT of less than 7.5 mm in previous cycles, including natural cycle (NC), hormone replacement treatment (HRT), and ovulation induction (OI) cycles...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28280497/activation-of-blood-cd3-cd56-cd8-t-cells-during-pregnancy-and-multiple-sclerosis
#6
Clara de Andrés, Lidia Fernández-Paredes, Marta Tejera-Alhambra, Bárbara Alonso, Rocío Ramos-Medina, Silvia Sánchez-Ramón
A striking common feature of most autoimmune diseases is their female predominance, with at least twice as common among women than men in relapsing-remitting multiple sclerosis (MS), the prevailing MS clinical form with onset at childbearing age. This fact, together with the protective effect on disease activity during pregnancy, when there are many biological changes including high levels of estrogens and progesterone, puts sex hormones under the spotlight. The role of natural killer (NK) and NKT cells in MS disease beginning and course is still to be elucidated...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28205459/effects-of-an-antagonistic-analog-of-growth-hormone-releasing-hormone-on-endometriosis-in-a-mouse-model-and-in-vitro
#7
Frank Köster, Li Jin, Yuanming Shen, Andrew V Schally, Ren-Zhi Cai, Norman L Block, Daniela Hornung, Gabriele Marschner, Achim Rody, Jörg B Engel, Dominique Finas
Endometriosis is a benign gynecologic disorder causing dysmenorrhea, pelvic pain, and subfertility. Receptors for the growth hormone-releasing hormone (GHRH) were found in endometriotic tissues. Antagonists of GHRH have been used to inhibit the growth of endometriotic endometrial stromal cells. In this study, the GHRH receptor splice variant (SV) 1 was detected in human endometrial tissue samples by Western blots and quantitative reverse transcription polymerase chain reaction (qRT-PCR). The highest messenger RNA (mRNA) and protein levels of SV1 were found in eutopic endometrium from patients with endometriosis compared to ectopic endometriotic tissues and endometrium from normal patients...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28145630/specific-photothermal-ablation-therapy-of-endometriosis-by-targeting-delivery-of-gold-nanospheres
#8
Xiaomeng Guo, Wei Li, Jialin Zhou, Wanqing Hou, Xue Wen, Hanbo Zhang, Fenfen Kong, Lihua Luo, Qingpo Li, Yongzhong Du, Jian You
Endometriosis is difficult to treat since the side effects of the current therapeutic method and the high recurrence rate; thus, newer and safer therapeutic approaches are urgently needed. This work investigates the enhanced permeability and retention effect of CdTe quantum dots (QDs) and hollow gold nanospheres (HAuNS) in endometriosis to increase the delivery of HAuNS into lesion cells. The surface of HAuNS is successfully conjugated with a TNYL peptide that has specific affinity for the EphB4 receptor, which is a member of the Eph family of receptor tyrosine kinases...
February 1, 2017: Small
https://www.readbyqxmd.com/read/27865465/dysregulation-of-aromatase-in-breast-endometrial-and-ovarian-cancers-an-overview-of-therapeutic-strategies
#9
P R Manna, D Molehin, A U Ahmed
Aromatase is the rate-limiting enzyme in the biosynthesis of estrogens, which play crucial roles on a spectrum of developmental and physiological processes. The biological actions of estrogens are classically mediated by binding to two estrogen receptors (ERs), ERα and ERβ. Encoded by the cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1) gene, aromatase is expressed in a wide variety of tissues, as well as benign and malignant tumors, and is regulated in a pathway- and tissue-specific manner...
2016: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/27639502/endometrial-and-conceptus-response-to-exogenous-progesterone-treatment-in-early-pregnant-gilts-following-hormonally-induced-estrus
#10
RANDOMIZED CONTROLLED TRIAL
Magdalena Szymanska, Agnieszka Blitek
The aim of the study was to determine how supplementation with exogenous progesterone (P4) affects the expression of genes important for endometrial receptivity and conceptus development during the peri-implantation period in pigs. Gilts with PMSG/hCG-induced first estrus received daily injections of corn oil (CO; n=7) or P4 (n=7) on days 3 to 10 after insemination. The dose of P4 was 25mg/100kg BW on days 3 and 4 of gestation, then increased to 50mg/100kg BW on days 5 to 10. Blood samples were collected each day to monitor concentrations of circulating P4...
November 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27451327/clinical-effects-of-the-fetal-estrogen-estetrol-in-a-multiple-rising-dose-study-in-postmenopausal-women
#11
Herjan J T Coelingh Bennink, Carole Verhoeven, Yvette Zimmerman, Monique Visser, Jean-Michel Foidart, Kristina Gemzell-Danielsson
OBJECTIVE: Estetrol (E4) is a natural fetal estrogen. The safety of increasing doses of E4 and its preliminary effects on the vagina, endometrium and menopausal vasomotor symptoms were investigated. STUDY DESIGN: This was a partly randomized, open-label, multiple-rising-dose study in 49 postmenopausal women. Subjects with an intact uterus were randomized to receive either 2mg E4 or 2mg estradiol-valerate (E2V) for 28days. Subsequent dose-escalation groups (non-randomized) were: 10mg E4 (intact uterus and ≥35 hot flushes/week); and 20mg and 40mg E4 (hysterectomized subjects)...
September 2016: Maturitas
https://www.readbyqxmd.com/read/27321759/menopausal-status-influences-the-expression-of-programmed-death-pd-1-and-its-ligand-pd-l1-on-immune-cells-from-the-human-female-reproductive-tract
#12
Zheng Shen, Marta Rodriguez-Garcia, Mickey V Patel, Fiona D Barr, Charles R Wira
PROBLEM: The programmed death 1 (PD-1)/PD-L1 pathway regulates peripheral tolerance, immune responses, and is up-regulated in chronic viral infections, including HIV infection. However, expression of PD-1/PD-L1 on immune cells from the human female reproductive tract (FRT) and possible regulation by menopause and sex hormones are poorly understood. METHOD OF STUDY: PD-1/PD-L1 expression was analyzed on CD4(+) and CD8(+) T cells, CD163(+) macrophages, and CD11c(+) dendritic cells (DC) from endometrium (EM), endocervix (CX) and ectocervix (ECX)...
August 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27138351/selective-progesterone-receptor-modulators-sprms-progesterone-receptor-action-mode-of-action-on-the-endometrium-and-treatment-options-in-gynecological-therapies
#13
Andrea Wagenfeld, Philippa T K Saunders, Lucy Whitaker, Hilary O D Critchley
INTRODUCTION: The progesterone receptor plays an essential role in uterine physiology and reproduction. Selective progesterone receptor modulators (SPRMs) have emerged as a valuable treatment option for hormone dependent conditions like uterine fibroids, which have a major impact on women's quality of life. SPRMs offer potential for longer term medical treatment and thereby patients may avoid surgical intervention. AREAS COVERED: The authors have reviewed the functional role of the progesterone receptor and its isoforms and their molecular mechanisms of action via genomic and non-genomic pathways...
September 2016: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/27097764/comparison-of-the-effect-of-lipopolysaccharide-on-tumor-necrosis-factor-%C3%AE-tnf-%C3%AE-secretion-and-tnf-and-tnfr1-mrna-levels-in-feline-endometrium-throughout-the-estrous-cycle-during-pyometra-and-after-medroxyprogesterone-acetate-treatment
#14
Ewelina Jursza-Piotrowska, Marta J Siemieniuch
Endotoxins released by Gram-negative bacteria are potent stimulators of tumor necrosis factor α (TNF-α) production. The objectives of this study were to evaluate plasma levels of TNF-α, TNF-α secretion, and mRNA levels of TNF and TNF-α receptor type 1 (TNFR1) following exposure to lipopolysaccharide (LPS). For this, we used cultured endometrial cells or organ cultures, throughout the estrous cycle, after hormone treatment with medroxyprogesterone acetate (MPA), and during pyometra. Plasma TNF-α concentrations were increased in animals at estrus (P < 0...
August 25, 2016: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/27067639/regulation-of-androgen-action-during-establishment-of-pregnancy
#15
REVIEW
Douglas A Gibson, Ioannis Simitsidellis, Philippa T K Saunders
During the establishment of pregnancy, the ovarian-derived hormones progesterone and oestradiol regulate remodelling of the endometrium to promote an environment that is able to support and maintain a successful pregnancy. Decidualisation is characterised by differentiation of endometrial stromal cells that secrete growth factors and cytokines that regulate vascular remodelling and immune cell influx. This differentiation process is critical for reproduction, and inadequate decidualisation is implicated in the aetiology of pregnancy disorders such as foetal growth restriction and preeclampsia...
July 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27062800/-a-multi-center-randomized-double-blind-clinical-study-on-bushen-huoxue-in-treatment-of-ovulatory-dysfunction-caused-infertility
#16
RANDOMIZED CONTROLLED TRIAL
Kun Ma, Yan-feng Liu, Jun-qin He, Min Li, Jing Shan
OBJECTIVE: The multi-center, randomized, double-blind, double-simulated and positive-control trial was used to verify the contribution degree of Bushen Huoxue for the treatment of ovulatory dysfunction caused infertility, which provided scientific basis for clinical treatment. METHOD: According to diagnostic, inclusion and exclusion criteria, we observed 349 patients which were divided into the treated group (n = 177, treated with Bushen Huoxue ricipe) and control group (n = 172, treated with clomiphene)...
October 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/27011208/effects-of-combination-of-estradiol-with-selective-progesterone-receptor-modulators-sprms-on-human-breast-cancer-cells-in-vitro-and-in-vivo
#17
Hareesh B Nair, Bindu Santhamma, Naveen K Krishnegowda, Kalarikkal V Dileep, Klaus J Nickisch
Use of estrogen or estrogen/progestin combination was an approved regimen for menopausal hormonal therapy (MHT). However, more recent patient-centered studies revealed an increase in the incidence of breast cancer in women receiving menopausal hormone therapy with estrogen plus progestin rather than estrogen alone. Tissue selective estrogen complex (TSEC) has been proposed to eliminate the progesterone component of MHT with supporting evidences. Based on our previous studies it is evident that SPRMs have a safer profile on endometrium in preventing unopposed estrogenicity...
2016: PloS One
https://www.readbyqxmd.com/read/26995894/effect-of-growth-hormone-on-endometrial-thickness-and-fertility-outcome-in-the-treatment-of-women-with-panhypopituitarism-a-case-report
#18
Panagiotis Drakopoulos, Nicola Pluchino, Paul Bischof, Pablo Cantero, Patrick Meyer, Didier Chardonnens
BACKGROUND: The role of growth hormone (GH) in female reproduction has become a topic of increasing interest over the last decade. The replacement of GH for ovulation induction in women with hypopituitarism remains controversial. The role of GH in the human endometrium is still largely unknown. To the best of our knowledge, this study represents the first case report showing evidence that GH might play a role not only for ovulation induction, but also for the development of endometrial thickness in women with hypopituitarism...
January 2016: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/26934922/in%C3%A2-vivo-and-in%C3%A2-vitro-studies-of-muc1-regulation-in-sheep-endometrium
#19
Kabir A Raheem, Waleed F A Marei, Bruce K Campbell, Ali A Fouladi-Nashta
In this study, we investigated the expression of mucin 1 (MUC1) mRNA and protein in sheep endometrium at different time points during follicular and luteal phases of estrous cycle, and also determined the effect of steroid hormone treatments and interferon tau (IFNτ) on MUC1 mRNA expression in endometrial cell culture in vitro. In experiment one, 15 Welsh mountain ewes were synchronized to a common estrus and killed at precise stages of estrous cycle corresponding to (1) pre-LH peak, (2) LH peak, (3) post-LH peak, (4) early luteal, and (5) mid-luteal...
June 2016: Theriogenology
https://www.readbyqxmd.com/read/26764121/a-prospective-open-label-multicenter-study-to-assess-the-pharmacodynamics-and-safety-of-repeated-use-of-30-mg-ulipristal-acetate
#20
MULTICENTER STUDY
C Jesam, L Cochon, A M Salvatierra, A Williams, N Kapp, D Levy-Gompel, V Brache
OBJECTIVE: Ulipristal acetate (UPA) 30 mg is safe and effective for emergency contraception (EC). This prospective open-label exploratory study was conducted to obtain additional data on the pharmacodynamic effects of repeated dose of UPA 30 mg during an 8-week period (effects on ovulation inhibition, hormonal levels, endometrium and cervical mucus). Safety and tolerability data of repeated use of UPA EC were also collected. STUDY DESIGN: A total of 23 healthy female, healthy sterilized women participated in two substudies receiving UPA for 8 consecutive weeks...
April 2016: Contraception
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