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Leukocyte poor platelet rich plasma

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https://www.readbyqxmd.com/read/27506585/leukocyte-poor-platelet-rich-plasma-is-more-effective-than-the-conventional-therapy-with-acetaminophen-for-the-treatment-of-early-knee-osteoarthritis
#1
Mario Simental-Mendía, José F Vílchez-Cavazos, Víctor M Peña-Martínez, Salvador Said-Fernández, Jorge Lara-Arias, Herminia Guadalupe Martínez-Rodríguez
INTRODUCTION: Knee osteoarthritis (OA) is a degenerative and progressive articular cartilage disease. Infiltration of autologous platelet-rich plasma (PRP) has been proposed as a therapeutic alternative due to the content of biologically active cytokines in PRP. We aimed to compare the clinical response of acetaminophen and intra-articular leukocyte-poor PRP (LP-PRP) in early knee OA. MATERIALS AND METHODS: A total of 65 patients with clinically and radiographically documented knee OA (grade 1-2) were analyzed...
August 9, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27503185/leukocyte-concentration-and-composition-in-platelet-rich-plasma-prp-influences-the-growth-factor-and-protease-concentrations
#2
Yohei Kobayashi, Yoshitomo Saita, Hirofumi Nishio, Hiroshi Ikeda, Yuji Takazawa, Masashi Nagao, Tomoiku Takaku, Norio Komatsu, Kazuo Kaneko
BACKGROUND: Platelet-rich plasma (PRP) therapy has become an increasingly popular treatment for orthopaedics and sports-related injuries, and various clinically available PRP preparation methods exist. However, the differences in PRP quality among numerous preparation methods remain unclear. Specifically, the benefit of including leukocytes in the PRP product remains controversial, and few studies have been conducted to evaluate the effects of the interaction between platelets and leukocytes on the growth factor concentrations...
September 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27268111/the-effectiveness-of-platelet-rich-plasma-in-the-treatment-of-tendinopathy-a-meta-analysis-of-randomized-controlled-clinical-trials
#3
Jane Fitzpatrick, Max Bulsara, Ming H Zheng
BACKGROUND: Tendinopathy is very common in the general population. There are increasing numbers of clinical studies referring to platelet-rich plasma (PRP) and platelet-poor plasma (PPP) as treatments for tendinopathy. PURPOSE: To perform a meta-analysis of the outcomes of the PRP groups by preparation method and injection technique in tendinopathy. To determine the clinical effectiveness of the preparations and to evaluate the effect of controls used in the studies reviewed...
June 6, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27217525/platelet-rich-plasma-in-a-murine-model-leukocytes-growth-factors-flt-1-and-muscle-healing
#4
Priscila Martins Andrade Denapoli, Roberta Sessa Stilhano, Sheila Jean McNeill Ingham, Sang Won Han, Rene Jorge Abdalla
BACKGROUND: It is well known that platelet-rich plasma (PRP) preparations are not the same and that not all preparations include white blood cells, but the part that leukocytes play on the healing role of PRP is still unknown. PURPOSE: The primary aim of this study was to evaluate the influence of leukocytes in different PRP preparations with a special emphasis on growth factor concentrations. The secondary aim was to evaluate the influence of PRP on muscle healing...
August 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27161868/the-properties-of-3-different-plasma-formulations-and-their-effects-on-tendinopathic-cells
#5
Eva Rubio-Azpeitia, Ane M Bilbao, Pello Sánchez, Diego Delgado, Isabel Andia
BACKGROUND: Tendinopathies are attributed to failure of the healing process and inadequate tissue remodeling. Plasma injections can trigger regenerative responses by modifying the molecular microenvironment. PURPOSE: To examine the differences in the mitotic, chemotactic, anabolic, and inflammatory effects between leukocyte- and platelet-rich plasma (L-PRP), platelet-rich plasma (PRP), and platelet-poor plasma (PPP). STUDY DESIGN: Controlled laboratory study...
August 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26831629/intra-articular-autologous-conditioned-plasma-injections-provide-safe-and-efficacious-treatment-for-knee-osteoarthritis-an-fda-sanctioned-randomized-double-blind-placebo-controlled-clinical-trial
#6
RANDOMIZED CONTROLLED TRIAL
Patrick A Smith
BACKGROUND: Platelet-rich plasma (PRP) injections have become an intriguing treatment option for osteoarthritis (OA), particularly OA of the knee. Despite the plethora of PRP-related citations, there is a paucity of high-level evidence that is comparable, cohort specific, dose controlled, injection protocol controlled, and double-blinded. PURPOSE: To determine the safety and efficacy of leukocyte-poor PRP autologous conditioned plasma (ACP) for knee OA treatment through a feasibility trial regulated by the US Food and Drug Administration (FDA)...
April 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26390166/autologous-platelet-rich-plasma-evidence-for-clinical-use
#7
REVIEW
Claudia S Cohn, Evelyn Lockhart
PURPOSE OF REVIEW: Autologous platelet-rich plasma (aPRP) is growing in popularity as a therapy to augment wound healing, speed the recovery from muscle and joint injuries, and enhance recovery after surgical repair. High-profile athletes treated with aPRP have increased the demand from the general population. Yet, evidence to support the use of aPRP in most clinical settings is weak, because of poorly controlled clinical trials. RECENT FINDINGS: Preparations of aPRP vary by platelet count, leukocyte content, and degree of platelet activation...
November 2015: Current Opinion in Hematology
https://www.readbyqxmd.com/read/26236743/immunohistochemical-expression-of-collagens-in-the-skin-of-horses-treated-with-leukocyte-poor-platelet-rich-plasma
#8
Maria Verônica de Souza, Mariana Brettas Silva, José de Oliveira Pinto, Marianna Barros de Souza Lima, Júlio Crepaldi, Gabriela Francine Martins Lopes, Hélio Batista dos Santos, Rosy Iara Maciel de Azambuja Ribeiro, Ralph Gruppi Thomé
This study evaluated the immunohistochemical expression of type I (COL I) and III (COL III) collagens during the healing process of skin treated with leukocyte-poor platelet-rich plasma (LP-PRP). Seven healthy gelding crossbred horses aged 16 to 17 years were used. Two rectangle-shaped wounds were created surgically in the right and left gluteal regions. Twelve hours after wound induction, 0.5 mL of the LP-PRP was administered in each edge of the wounds of one of the gluteal regions. The contralateral region was used as control (CG)...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26006082/bradykinin-and-capsaicin-induced-airways-obstruction-in-the-guinea-pig-are-platelet-dependent
#9
S D Keir, D Spina, C P Page
INTRODUCTION: Airways obstruction induced by intravenously administered bradykinin is abolished in guinea pigs treated with indomethacin, which has been shown to be, at least in part thromboxane dependent. As thromboxane is primarily generated from circulating platelets, we investigated whether airways obstruction induced by bradykinin, and other spasmogens, is platelet dependent and the role platelet aggregation played in this response. METHODS: Guinea pigs were chronically treated with busulfan to induce thrombocytopenia...
August 2015: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/25957981/does-intraoperative-application-of-leukocyte-poor-platelet-rich-plasma-during-arthroscopy-for-knee-degeneration-affect-postoperative-pain-function-and-quality-of-life-a-12-month-randomized-controlled-double-blind-trial
#10
RANDOMIZED CONTROLLED TRIAL
Christian Duif, Tobias Vogel, Fatma Topcuoglu, Georgios Spyrou, Christoph von Schulze Pellengahr, Matthias Lahner
INTRODUCTION: We aimed to identify the effects of intraoperative applied leukocyte-poor platelet-rich plasma (LP-PRP) during knee arthroscopy for degenerative lesions involving pain, function and quality of life. METHODS: We performed a randomized controlled, double-blind trial (RCT) including 58 patients for arthroscopic knee surgery for cartilage or meniscal degeneration with allocation into the LP-PRP (n = 24) or control group (n = 34). During arthroscopy, LP-PRP was injected intra-articular in the intervention group...
July 2015: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/25925602/effect-of-leukocyte-concentration-on-the-efficacy-of-platelet-rich-plasma-in-the-treatment-of-knee-osteoarthritis
#11
Jonathan C Riboh, Bryan M Saltzman, Adam B Yanke, Lisa Fortier, Brian J Cole
BACKGROUND: Leukocyte-poor platelet-rich plasma (LP-PRP) is hypothesized to be more suitable for intra-articular injection than leukocyte-rich PRP (LR-PRP) in the treatment of knee osteoarthritis. PURPOSE: To compare clinical outcomes and rates of adverse reactions between LP-PRP and LR-PRP for this application. STUDY DESIGN: Meta-analysis. METHODS: The MEDLINE, EMBASE, and Cochrane databases were reviewed. The primary outcome was the incidence of local adverse reactions...
March 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/25920634/leukocyte-poor-platelet-rich-plasma-versus-bupivacaine-for-recalcitrant-lateral-epicondylar-tendinopathy
#12
RANDOMIZED CONTROLLED TRIAL
Prateek Behera, Mandeep Dhillon, Sameer Aggarwal, Neelam Marwaha, Mahesh Prakash
PURPOSE: To compare a single leukocyte-poor (type-4B) platelet-rich plasma (PRP) injection versus bupivacaine injection for recalcitrant lateral epicondylar tendinopathy (LET). METHODS: 25 patients aged 27 to 50 years with painful and recalcitrant LET of the humerus were randomised to receive leukocyte-poor (type-4B) PRP (n=15) or bupivacaine (n=10) injection. Outcome measures included visual analogue scale (VAS) for pain, modified Mayo clinic performance index for elbow (MMCPIE) for elbow function, and Nirschl score for activity-related pain at 1, 3, 6, and 12 months by a single assessor...
April 2015: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/25889052/effects-of-sodium-citrate-and-acid-citrate-dextrose-solutions-on-cell-counts-and-growth-factor-release-from-equine-pure-platelet-rich-plasma-and-pure-platelet-rich-gel
#13
Carlos E Giraldo, María E Álvarez, Jorge U Carmona
BACKGROUND: There is a lack information on the effects of the most commonly used anticoagulants for equine platelet rich plasmas (PRPs) elaboration on cell counts and growth factor release from platelet rich gels (PRGs). The aims of this study were 1) to compare the effects of the anticoagulants sodium citrate (SC), acid citrate dextrose solution A (ACD-A) and ACD-B on platelet (PLT), leukocyte (WBC) and on some parameters associated to platelet activation including mean platelet volume (MPV) and platelet distribution width (PDW) between whole blood, pure PRP (P-PRP) and platelet-poor plasma (PPP); 2) to compare transforming growth factor beta 1 (TGF-β(1)) and platelet-derived growth factor isoform BB (PDGF-BB) concentrations in supernatants from pure PRG (P-PRG), platelet-poor gel (PPG), P-PRP lysate (positive control) and plasma (negative control); 3) to establish the possible correlations between all the studied cellular and molecular parameters...
March 14, 2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/25779815/effects-of-sodium-citrate-and-acid-citrate-dextrose-solutions-on-cell-counts-and-growth-factor-release-from-equine-pure-platelet-rich-plasma-and-pure-platelet-rich-gel
#14
Carlos E Giraldo, María E Álvarez, Jorge U Carmona
BACKGROUND: There is a lack information on the effects of the most commonly used anticoagulants for equine platelet rich plasmas (PRPs) elaboration on cell counts and growth factor release from platelet rich gels (PRGs). The aims of this study were 1) to compare the effects of the anticoagulants sodium citrate (SC), acid citrate dextrose solution A (ACD-A) and ACD-B on platelet (PLT), leukocyte (WBC) and on some parameters associated to platelet activation including mean platelet volume (MPV) and platelet distribution width (PDW) between whole blood, pure PRP (P-PRP) and platelet-poor plasma (PPP); 2) to compare transforming growth factor beta 1 (TGF-β1) and platelet-derived growth factor isoform BB (PDGF-BB) concentrations in supernatants from pure PRG (P-PRG), platelet-poor gel (PPG), P-PRP lysate (positive control) and plasma (negative control); 3) to establish the possible correlations between all the studied cellular and molecular parameters...
December 2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/25506468/temporal-bacteriostatic-effect-and-growth-factor-loss-in-equine-platelet-components-and-plasma-cultured-with-methicillin-sensitive-and-methicillin-resistant-staphylococcus-aureus-a-comparative-in-vitro-study
#15
Catalina López, María E Alvarez, Jorge U Carmona
The aims were (1) to evaluate the bacteriostatic effect of platelet-rich plasma (PRP), platelet-rich gel (PRG), leukocyte-poor plasma (LPP), leukocyte-poor gel (LPG), plasma, and heat-inactivated plasma (IP) on both methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) over a period of 24 h; (2) to determine and to compare the concentrations and degradation over time of platelet factor 4 (PF-4), transforming growth factor beta 1 (TGF-β 1), and platelet-derived growth factor isoform BB (PDGF-BB); and (3) to identify any correlations between MSSA and MRSA growth and either the cellular, PF-4, TGF-β 1, or PDGF-BB concentrations in the blood components...
2014: Veterinary Medicine International
https://www.readbyqxmd.com/read/25106017/platelet-rich-preparations-to-improve-healing-part-ii-platelet-activation-and-enrichment-leukocyte-inclusion-and-other-selection-criteria
#16
REVIEW
Vicki L Davis, Alaeddin B Abukabda, Nicholas M Radio, Paula A Witt-Enderby, William P Clafshenkel, J Vito Cairone, James L Rutkowski
Multiple platelet-rich preparations have been reported to improve wound and bone healing, such as platelet-rich plasma (PRP) and platelet rich fibrin (PRF). The different methods employed during their preparation are important, as they influence the quality of the product applied to a wound or surgical site. Besides the general protocol for preparing the platelet-rich product (discussed in Part 1 of this review), multiple choices need to be considered during its preparation. For example, activation of the platelets is required for the release and enmeshment of growth factors, but the method of activation may influence the resulting matrix, growth factor availability, and healing...
August 2014: Journal of Oral Implantology
https://www.readbyqxmd.com/read/25088784/bacteriostatic-effect-of-equine-pure-platelet-rich-plasma-and-other-blood-products-against-methicillin-sensitive-staphylococcus-aureus-an-in-vitro-study
#17
C López, J U Carmona, C E Giraldo, M E Alvarez
OBJECTIVES: 1) To evaluate the bacteriostatic in vitro effect of pure platelet-rich plasma (P-PRP), pure platelet-rich gel (P-PRG), leukocyte-poor gel (LPG), platelet-poor plasma (PPP), and heat inactivated plasma (IP) against methicillin-sensitive Staphylococcus aureus (MSSA) over a period of 24 hours. 2) To determine the degradation of platelet factor-4 (PF-4), transforming growth factor beta 1 (TGF-β1), and platelet-derived growth factor isoform BB (PDGF-BB) in these equine blood components...
2014: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/24868905/-methods-of-preparation-of-the-platelet-rich-plasma-used-in-medicine-as-an-accelerator-of-tissue-regeneration
#18
REVIEW
Lena Kesy, Przemysław Kopczyński, Aleksandra Baszczuk, Zygmunt Kopczyński
Platelet rich plasma is being increasingly used in the modem medicine as a material, stimulating regeneration and accelerating tissue healing. Platelet rich plasma is an autologous platelet concentrate, which is obtained from the peripheral blood of the patient. The method of extraction is based on the isolation of platelets during centrifugation of the whole blood, drew on anticoagulant. With the difference in density between the various cellular components of blood, such as red blood cells, buffy coat and platelet poor plasma, the separation into individual fractions is possible...
April 2014: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/24725317/characterization-and-comparison-of-5-platelet-rich-plasma-preparations-in-a-single-donor-model
#19
COMPARATIVE STUDY
Jeremy Magalon, Olivier Bausset, Nicolas Serratrice, Laurent Giraudo, Houssein Aboudou, Julie Veran, Guy Magalon, Françoise Dignat-Georges, Florence Sabatier
PURPOSE: The purpose of this study was to compare the biological characteristics of platelet-rich plasma (PRP) obtained from 4 medical devices and a preparation developed in our laboratory using a single-donor model. METHODS: Ten healthy persons donated blood that was processed to produce PRP by use of 4 commercial preparation systems and a protocol developed in our laboratory. Volumes and platelet, white blood cell (WBC), and red blood cell concentrations were recorded...
May 2014: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/24634448/the-effect-of-platelet-rich-plasma-formulations-and-blood-products-on-human-synoviocytes-implications-for-intra-articular-injury-and-therapy
#20
Hillary J Braun, Hyeon Joo Kim, Constance R Chu, Jason L Dragoo
BACKGROUND: The effect of platelet-rich plasma (PRP) on chondrocytes has been studied in cell and tissue culture, but considerably less attention has been given to the effect of PRP on synoviocytes. Fibroblast-like synoviocytes (FLS) compose 80% of the normal human synovium and produce cytokines and matrix metalloproteinases that can mediate cartilage catabolism. PURPOSE: To compare the effects of leukocyte-rich PRP (LR-PRP), leukocyte-poor PRP (LP-PRP), red blood cell (RBC) concentrate, and platelet-poor plasma (PPP) on human FLS to determine whether leukocyte and erythrocyte concentrations of PRP formulations differentially affect the production of inflammatory mediators...
May 2014: American Journal of Sports Medicine
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