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Radiogenomics

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https://www.readbyqxmd.com/read/28079715/from-k-space-to-nucleotide-insights-into-the-radiogenomics-of-brain-tumors
#1
Nabil Elshafeey, Islam Hassan, Pascal O Zinn, Rivka R Colen
Radiogenomics is a relatively new and exciting field within radiology that links different imaging features with diverse genomic events. Genomics advances provided by the Cancer Genome Atlas and the Human Genome Project have enabled us to harness and integrate this information with noninvasive imaging phenotypes to create a better 3-dimensional understanding of tumor behavior and biology. Beyond imaging-histopathology, imaging genomic linkages provide an important layer of complexity that can help in evaluating and stratifying patients into clinical trials, monitoring treatment response, and enhancing patient outcomes...
January 11, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28079712/a-comprehensive-review-of-genomics-and-noncoding-rna-in-gliomas
#2
Ahmed Hassan, Jennifer Mosley, Sanjay Singh, Pascal Olivier Zinn
Glioblastoma (GBM) is the most malignant primary adult brain tumor. In spite of our greater understanding of the biology of GBMs, clinical outcome of GBM patients remains poor, as their median survival with best available treatment is 12 to 18 months. Recent efforts of The Cancer Genome Atlas (TCGA) have subgrouped patients into 4 molecular/transcriptional subgroups: proneural, neural, classical, and mesenchymal. Continuing efforts are underway to provide a comprehensive map of the heterogeneous makeup of GBM to include noncoding transcripts, genetic mutations, and their associations to clinical outcome...
January 11, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28048816/mo-de-207b-05-predicting-gene-mutations-in-renal-cell-carcinoma-based-on-ct-imaging-features-validation-using-tcga-tcia-datasets
#3
X Chen, Z Zhou, K Thomas, J Wang
PURPOSE: The goal of this work is to investigate the use of contrast enhanced computed tomographic (CT) features for the prediction of mutations of BAP1, PBRM1, and VHL genes in renal cell carcinoma (RCC). METHODS: For this study, we used two patient databases with renal cell carcinoma (RCC). The first one consisted of 33 patients from our institution (UT Southwestern Medical Center, UTSW). The second one consisted of 24 patients from the Cancer Imaging Archive (TCIA), where each patient is connected by a unique identi?er to the tissue samples from the Cancer Genome Atlas (TCGA)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048692/mo-fg-207b-01-thorax-lung
#4
H Aerts
State-of-the-Art in Radiomics in Radiology and Radiation Oncology Radiomics is the science of converting medical images into mineable data, data that are descriptive of "phenotypes," which may provide diagnostic, prognostic, or therapeutic information. Genomics is the science of sequencing and analyzing the function and structure of genomes; the complete set of DNA in a single cell of an organism. In turn, imaging genomics (or radiogenomics) is concerned with the correlation between image-based features, as determined by radiomics, and gene expression, as determined by genomics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048236/su-f-r-01-preclinical-radioimmunogenomics-study-to-design-personalized-radiotherapy
#5
H Abdollahi
PURPOSE: Radiogenomics is an active area of research to find clinical correlation between genomics and radiotherapy outcomes. In this era, many different biological issues should be taken into account. In this study we aimed to introduce "Radioimmunogenomics" as a new approach to study immunogetics issue regard to radiotherapy induced clinical manifestations. METHODS: We studied different immunological pathways and signaling molecules which underling radiation response of normal and malignant tissues...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048031/mo-fg-207b-02-breast
#6
H Li
State-of-the-Art in Radiomics in Radiology and Radiation Oncology Radiomics is the science of converting medical images into mineable data, data that are descriptive of "phenotypes," which may provide diagnostic, prognostic, or therapeutic information. Genomics is the science of sequencing and analyzing the function and structure of genomes; the complete set of DNA in a single cell of an organism. In turn, imaging genomics (or radiogenomics) is concerned with the correlation between image-based features, as determined by radiomics, and gene expression, as determined by genomics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047352/mo-fg-207b-03-brain
#7
P Tiwari
State-of-the-Art in Radiomics in Radiology and Radiation Oncology Radiomics is the science of converting medical images into mineable data, data that are descriptive of "phenotypes," which may provide diagnostic, prognostic, or therapeutic information. Genomics is the science of sequencing and analyzing the function and structure of genomes; the complete set of DNA in a single cell of an organism. In turn, imaging genomics (or radiogenomics) is concerned with the correlation between image-based features, as determined by radiomics, and gene expression, as determined by genomics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047293/tu-b-207b-00-challenges-in-radiomics-and-big-data
#8
Karen Drukker
The general learning objectives are to get a better understanding of • The pitfalls along the radiomics/radiogenomics (imaging genomics) pipeline • The crucial role of statistics in the design and evaluation of radiomics/radiogenomics phenotypes and systems • The special challenges associated with big data 1. Introduction a. Basic statistical concepts b. Association, correlation, and causality c. Know when your numbers are significant 2. Reproducibility a. Replication studies i. The extent of the problem ii...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046682/mo-fg-207b-04-respond-to-therapy
#9
W Lu
State-of-the-Art in Radiomics in Radiology and Radiation Oncology Radiomics is the science of converting medical images into mineable data, data that are descriptive of "phenotypes," which may provide diagnostic, prognostic, or therapeutic information. Genomics is the science of sequencing and analyzing the function and structure of genomes; the complete set of DNA in a single cell of an organism. In turn, imaging genomics (or radiogenomics) is concerned with the correlation between image-based features, as determined by radiomics, and gene expression, as determined by genomics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046637/mo-fg-207b-00-state-of-the-art-in-radiomics-in-radiology-and-radiation-oncology
#10
Maryellen Giger, Joseph Deasy
State-of-the-Art in Radiomics in Radiology and Radiation Oncology Radiomics is the science of converting medical images into mineable data, data that are descriptive of "phenotypes," which may provide diagnostic, prognostic, or therapeutic information. Genomics is the science of sequencing and analyzing the function and structure of genomes; the complete set of DNA in a single cell of an organism. In turn, imaging genomics (or radiogenomics) is concerned with the correlation between image-based features, as determined by radiomics, and gene expression, as determined by genomics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046620/tu-b-207b-01-challenges-in-radiomics-and-big-data
#11
K Drukker
The general learning objectives are to get a better understanding of • The pitfalls along the radiomics/radiogenomics (imaging genomics) pipeline • The crucial role of statistics in the design and evaluation of radiomics/radiogenomics phenotypes and systems • The special challenges associated with big data 1. Introduction a. Basic statistical concepts b. Association, correlation, and causality c. Know when your numbers are significant 2. Reproducibility a. Replication studies i. The extent of the problem ii...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28012356/radiogenomic-evaluation-of-lung-cancer-are-there-imaging-characteristics-associated-with-lung-adenocarcinomas-harboring-braf-mutations
#12
Darragh F Halpenny, Andrew Plodkowski, Gregory Riely, Junting Zheng, Anya Litvak, Chaya Moscowitz, Michelle S Ginsberg
INTRODUCTION: We studied computed tomography (CT) features associated with BRAF mutated lung cancer. MATERIALS AND METHODS: CT features of BRAF mutated lung cancers were compared to stage matched lesions without BRAF mutation. RESULTS: 47 (25%) patients with BRAF mutation and 141 (75%) without BRAF mutation were included. BRAF lesions were most frequently solid 37 (84%), spiculated 22 (50%), and peripheral 37 (84%). No feature of the primary tumor was significantly different between BRAF and non-BRAF groups...
November 30, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27979370/optimal-design-and-patient-selection-for-interventional-trials-using-radiogenomic-biomarkers-a-requite-and-radiogenomics-consortium-statement
#13
REVIEW
Dirk De Ruysscher, Gilles Defraene, Bram L T Ramaekers, Philippe Lambin, Erik Briers, Hilary Stobart, Tim Ward, Søren M Bentzen, Tjeerd Van Staa, David Azria, Barry Rosenstein, Sarah Kerns, Catharine West
The optimal design and patient selection for interventional trials in radiogenomics seem trivial at first sight. However, radiogenomics do not give binary information like in e.g. targetable mutation biomarkers. Here, the risk to develop severe side effects is continuous, with increasing incidences of side effects with higher doses and/or volumes. In addition, a multi-SNP assay will produce a predicted probability of developing side effects and will require one or more cut-off thresholds for classifying risk into discrete categories...
December 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27742114/shedding-light-on-the-2016-world-health-organization-classification-of-tumors-of-the-central-nervous-system-in-the-era-of-radiomics-and-radiogenomics
#14
REVIEW
Rivka R Colen, Islam Hassan, Nabil Elshafeey, Pascal O Zinn
The new World Health Organization classification of brain tumors depends on combining the histologic light microscopy features of central nervous system (CNS) tumors with canonical genetic alterations. This integrated diagnosis is redrawing the pedigree chart of brain tumors with rearrangement of tumor groups on the basis of geno-phenotypical behaviors into meaningful groups. Multiple radiogenomic studies provide a bridge between imaging features and tumor microenvironment. An overlap that can be integrated within the genophenotypical classification of CNS tumors for a better understanding of different clinically relevant entities...
November 2016: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27742112/radiomics-in-brain-tumors-an-emerging-technique-for-characterization-of-tumor-environment
#15
REVIEW
Aikaterini Kotrotsou, Pascal O Zinn, Rivka R Colen
The role of radiomics in the diagnosis, monitoring, and therapy planning of brain tumors is becoming increasingly clear. Incorporation of quantitative approaches in radiology, in combination with increased computer power, offers unique insights into macroscopic tumor characteristics and their direct association with the underlying pathophysiology. This article presents the most recent findings in radiomics and radiogenomics with respect to identifying potential imaging biomarkers with prognostic value that can lead to individualized therapy...
November 2016: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27742105/unravelling-tumour-heterogeneity-using-next-generation-imaging-radiomics-radiogenomics-and-habitat-imaging
#16
REVIEW
E Sala, E Mema, Y Himoto, H Veeraraghavan, J D Brenton, A Snyder, B Weigelt, H A Vargas
Tumour heterogeneity in cancers has been observed at the histological and genetic levels, and increased levels of intra-tumour genetic heterogeneity have been reported to be associated with adverse clinical outcomes. This review provides an overview of radiomics, radiogenomics, and habitat imaging, and examines the use of these newly emergent fields in assessing tumour heterogeneity and its implications. It reviews the potential value of radiomics and radiogenomics in assisting in the diagnosis of cancer disease and determining cancer aggressiveness...
January 2017: Clinical Radiology
https://www.readbyqxmd.com/read/27739434/multiparametric-mri-based-differentiation-of-who-grade-ii-iii-glioma-and-who-grade-iv-glioblastoma
#17
Benedikt Wiestler, Anne Kluge, Mathias Lukas, Jens Gempt, Florian Ringel, Jürgen Schlegel, Bernhard Meyer, Claus Zimmer, Stefan Förster, Thomas Pyka, Christine Preibisch
Non-invasive, imaging-based examination of glioma biology has received increasing attention in the past couple of years. To this end, the development and refinement of novel MRI techniques, reflecting underlying oncogenic processes such as hypoxia or angiogenesis, has greatly benefitted this research area. We have recently established a novel BOLD (blood oxygenation level dependent) based MRI method for the measurement of relative oxygen extraction fraction (rOEF) in glioma patients. In a set of 37 patients with newly diagnosed glioma, we assessed the performance of a machine learning model based on multiple MRI modalities including rOEF and perfusion imaging to predict WHO grade...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27675723/integrative-radiogenomic-profiling-identifies-non-v600-kinase-domain-braf-mutations-as-novel-radiotherapeutic-targets-in-adenocarcinomas-of-the-lung
#18
E K Chie, P Gopal, M Abazeed
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27649026/progress-in-neuro-imaging-of-brain-tumors
#19
Antonella Castellano, Andrea Falini
PURPOSE OF REVIEW: Magnetic resonance imaging (MRI) is routinely employed in the diagnosis and clinical management of brain tumors. This review provides an overview of the advancements in the field of MRI, with a particular focus on the quantitative assessment by advanced physiological magnetic resonance techniques in light of the new molecular classification of brain tumor. RECENT FINDINGS: Understanding how molecular phenotypes of brain tumors are reflected in noninvasive imaging is the goal of radiogenomics, which aims at determining the association between imaging features and molecular markers in neuro-oncology...
November 2016: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27639313/lung-adenocarcinomas-correlation-of-computed-tomography-and-pathology-findings
#20
J G Cohen, E Reymond, A Jankowski, E Brambilla, F Arbib, S Lantuejoul, G R Ferretti
Adenocarcinoma is the most common histologic type of lung cancer. Recent lung adenocarcinoma classifications from the International Association for the Study of Lung cancer, the American Thoracic Society and the European Respiratory Society (IASLC/ETS/ERS, 2011) and World Health Organization (WHO, 2015) define a wide range of adenocarcinoma types and subtypes featuring different prognosis and management. This spectrum of lesions translates into various CT presentations and features, which generally show good correlation with histopathology, stressing the key role of the radiologist in the diagnosis and management of those patients...
October 2016: Diagnostic and Interventional Imaging
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