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https://www.readbyqxmd.com/read/29771383/relationship-of-fibroblast-growth-factor-21-with-kidney-function-and-albuminuria-multi-ethnic-study-of-atherosclerosis
#1
Sahapab Anuwatmatee, Matthew A Allison, Michael G Shlipak, Robyn L McClelland, Holly Kramer, Shudi Tang, Liming Hou, Kerry-Anne Rye, Kwok Leung Ong
Background: Fibroblast growth factor 21 (FGF21) may play a role in the development of chronic kidney disease (CKD). We therefore investigated the relationship of plasma FGF21 levels with kidney function and albuminuria in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: The analysis included 5724 MESA participants ages 45-84 years between 2000 and 2002, free of clinically apparent cardiovascular disease (CVD). Participants were followed up in person at four additional clinic visits over 10 years...
May 15, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29766678/association-between-bone-mineral-density-and-albuminuria-cross-sectional-analysis-of-data-from-the-2011-korea-national-health-and-nutrition-examination-survey-v-2
#2
Tae Yang Yu, Ha Young Kim, Jeong Mi Lee, Dae Ho Lee, Chung Gu Cho
BACKGROUND: Albuminuria is known to be independently associated with progression of renal and cardiovascular disease. However, little is known regarding the exact relationship between albuminuria and bone mineral density (BMD). The aim of this population-based study conducted in Korea was to identify the association between albuminuria and BMD. METHODS: We performed a cross-sectional analysis of data from the Korea National Health and Nutrition Examination Survey (KNHANES V-2) 2011...
May 4, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29761089/association-of-haemodynamic-indices-of-central-and-peripheral-pressure-with-subclinical-target-organ-damage
#3
Junli Zuo, Shaoli Chu, Isabella Tan, Mark Butlin, Jiehui Zhao, Alberto Avolio
Background: Central aortic pressure has often been shown to be more closely associated with markers of vascular function and incidence of cardiovascular events compared to peripheral pressure. However, the potential clinical use of central aortic or peripheral haemodynamic indices as markers of target organ damage (TOD) has not been fully established. Methods: We evaluated associations of TOD with central aortic and peripheral haemodynamic indices (central aortic [cPP] and peripheral pulse pressure [pPP], central aortic augmentation index, and central and peripheral waveform factor) in 770 hospital inpatients (age 60 ± 10 years, 473 males) with primary hypertension...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29723897/relationship-between-the-brain-natriuretic-peptide-bnp-level-and-prognosis-of-diabetic-nephropathy-with-microalbuminuria-a-7-year-follow-up-study
#4
Naoto Seki, Tsuyoshi Matsumoto, Motoharu Fukazawa
The aim of the study was to examine the relationship between the brain natriuretic peptide (BNP) level and prognosis of diabetic nephropathy. The subjects were 100 Japanese outpatients with type 2 diabetes mellitus with microalbuminuria. Associations between metabolic parameters at baseline, including BNP, and prognosis of diabetic nephropathy (progression of diabetic nephropathy, cardiovascular events, and death) were examined for 7 years. In Cox proportional hazard analysis, HbA1c, albumin-creatinine ratio (ACR) and BNP were identified as significant factors for progression of diabetic nephropathy (p=0...
May 3, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29704542/ambulatory-blood-pressure-and-endothelial-dysfunction-in-hematopoietic-cell-transplant-patients
#5
Emily Pao, Nancy E Gove, Joseph Flynn, Sangeeta Hingorani
Hematopoietic cell transplantation (HCT) is a common treatment for many disorders. Albuminuria post-HCT, which may represent endothelial injury or inflammation from graft vs. host disease, increases the risk of chronic kidney disease and non-relapse mortality at 1 year. HCT patients also have abnormal blood pressure (BP) and increased rates of cardiovascular complications. We sought to determine the relationships between albuminuria, endothelial dysfunction and BP in HCT patients. Patients ≥ 12 years of age who had their first allogeneic HCT between 2012-2015 and survived through day 80 were eligible...
April 25, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29698955/serum-uromodulin-a-biomarker-of-long-term-kidney-allograft-failure
#6
Andrew Bostom, Dominik Steubl, Pranav S Garimella, Nora Franceschini, Mary B Roberts, Andreas Pasch, Joachim H Ix, Katherine R Tuttle, Anastasia Ivanova, Theresa Shireman, S Joseph Kim, Reginald Gohh, Daniel E Weiner, Andrew S Levey, Chi-Yuan Hsu, John W Kusek, Charles B Eaton
BACKGROUND: Uromodulin is a kidney-derived glycoprotein and putative tubular function index. Lower serum uromodulin was recently associated with increased risk for kidney allograft failure in a preliminary, longitudinal single-center -European study involving 91 kidney transplant recipients (KTRs). METHODS: The Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial is a completed, large, multiethnic controlled clinical trial cohort, which studied chronic, stable KTRs...
April 26, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29693449/a-translational-model-of-chronic-kidney-disease-in-swine
#7
Alejandro R Chade, Maxx L Williams, Jason E Engel, Erika Guise, Taylor W Harvey
Animal models of chronic kidney disease (CKD) are critical for understanding its pathophysiology and for therapeutic development. The cardiovascular and renal anatomy and physiology of the pig are virtually identical to humans. This study aimed to develop a novel translational model of CKD that mimics the pathological features of CKD in humans. CKD was induced in 7 domestic pigs by bilateral renal artery stenosis and diet-induced dyslipidemia. Animals were observed for a total of 14 weeks. Renal hemodynamics and function were quantified in vivo using multi-detector CT after 6, 10, and 14 weeks of CKD...
April 25, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29687557/osteopontin-as-a-marker-of-vasculopathy-in-pediatric-patients-with-type-1-diabetes-mellitus-relation-to-vascular-structure
#8
Mohamed Abo El-Asrar, Eman Abdel Rahman Ismail, Rasha Adel Thabet, Ashraf Sayed Kamel, Sameh NehmedAllah
BACKGROUND: Type 1 diabetes mellitus (T1DM) is associated with serious micro-vascular and macrovascular complications. Osteopontin (OPN) has emerged as a strong predictor of incipient diabetic nephropathy and a first-ever cardiovascular event in adults with T1DM. OPN is linked to coronary atherosclerosis in type 2 diabetes. AIM: To test the hypothesis that OPN could be a potential marker for micro-vascular complications in children and adolescents with T1DM and we assessed its relation to carotid and aortic intima media thickness (CIMT and AIMT) as non-invasive index for subclinical atherosclerosis...
April 23, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29682347/prevalence-of-microalbuminuria-in-adult-patients-with-sickle-cell-disease-in-eastern-saudi-arabia
#9
Ahmed M Alkhunaizi, Adil A Al-Khatti, Mansour A Alkhunaizi
Background: Proteinuria is a common feature of sickle cell nephropathy (SCN) that can progress to renal insufficiency and end stage renal disease. Microalbuminuria (MA) is the earliest manifestation of SCN and precedes the development of overt proteinuria. In addition to the renal consequences, MA is linked to cardiovascular complications. Periodic screening and early detection of MA allow early intervention that may reduce the risk of progression to advanced renal failure and cardiovascular diseases...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29671286/assessment-of-potential-renal-dysfunction-in-patients-with-congenital-heart-disease-after-biventricular-repair
#10
Hideharu Oka, Kouichi Nakau, Aya Kajihama, Hiroshi Azuma
BACKGROUND AND OBJECTIVES: There are few reports on renal dysfunction in the remote period after biventricular repair, and biomarkers for early detection of renal dysfunction are not well understood. We examined whether early fluctuation of biomarkers of renal function occurs in the remote period after biventricular repair in patients with congenital heart disease (CHD). METHODS: Fourteen patients with CHD after biventricular repair were included. The examination values obtained by cardiac catheterization test and renal function indices based on blood and urine sampling were compared...
April 2, 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29663995/-risk-factors-of-atrial-fibrillation-in-critical-ill-patients
#11
Jianyu Fu, Hongying Bi, Yunsong Xia, Hui Fang, Xu Liu, Yan Tang, Difen Wang
OBJECTIVE: To observe the clinical features of atrial fibrillation (AF) patients, and to explore the correlation between the routine detection index and the new-onset AF and to find out risk factors for new AF in critically ill patients. METHODS: A prospective observational study was conducted. The patients with AF admitted to intensive care unit (ICU) of the Affiliated Hospital of Guizhou Medical University from March 2016 to June 2017 were enrolled. The patients were divided into new-onset AF group and past-existed AF group according to their past history of AF (including persistent AF, paroxysmal AF or permanent AF)...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29655829/renal-effects-and-associated-outcomes-during-angiotensin-neprilysin-inhibition-in-heart-failure
#12
Kevin Damman, Mauro Gori, Brian Claggett, Pardeep S Jhund, Michele Senni, Martin P Lefkowitz, Margaret F Prescott, Victor C Shi, Jean L Rouleau, Karl Swedberg, Michael R Zile, Milton Packer, Akshay S Desai, Scott D Solomon, John J V McMurray
OBJECTIVES: The purpose of this study was to evaluate the renal effects of sacubitril/valsartan in patients with heart failure and reduced ejection fraction. BACKGROUND: Renal function is frequently impaired in patients with heart failure with reduced ejection fraction and may deteriorate further after blockade of the renin-angiotensin system. METHODS: In the PARADIGM-HF (Prospective Comparison of ARNI with ACE inhibition to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial, 8,399 patients with heart failure with reduced ejection fraction were randomized to treatment with sacubitril/valsartan or enalapril...
April 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29643156/indecho-study-cohort-study-investigating-birth-size-childhood-growth-and-young-adult-cardiovascular-risk-factors-as-predictors-of-midlife-myocardial-structure-and-function-in-south-asians
#13
Senthil K Vasan, Ambuj Roy, Viji Thomson Samuel, Belavendra Antonisamy, Santosh K Bhargava, Anoop George Alex, Bhaskar Singh, Clive Osmond, Finney S Geethanjali, Fredrik Karpe, Harshpal Sachdev, Kanhaiya Agrawal, Lakshmy Ramakrishnan, Nikhil Tandon, Nihal Thomas, Prasanna S Premkumar, Prrathepa Asaithambi, Sneha F X Princy, Sikha Sinha, Thomas Vizhalil Paul, Dorairaj Prabhakaran, Caroline H D Fall
INTRODUCTION: South Asians have high rates of cardiovascular disease (CVD) and its risk factors (hypertension, diabetes, dyslipidaemia and central obesity). Left ventricular (LV) hypertrophy and dysfunction are features of these disorders and important predictors of CVD mortality. Lower birth and infant weight and greater childhood weight gain are associated with increased adult CVD mortality, but there are few data on their relationship to LV function. The IndEcho study will examine associations of birth size, growth during infancy, childhood and adolescence and CVD risk factors in young adulthood with midlife cardiac structure and function in South Asian Indians...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29643059/higher-collagen-vi-formation-is-associated-with-all-cause-mortality-in-patients-with-type-2-diabetes-and-microalbuminuria
#14
Daniel G K Rasmussen, Tine W Hansen, Bernt J von Scholten, Signe H Nielsen, Henrik Reinhard, Hans-Henrik Parving, Martin Tepel, Morten A Karsdal, Peter K Jacobsen, Federica Genovese, Peter Rossing
OBJECTIVE: Type 2 diabetes is a common risk factor for the development of chronic kidney disease (CKD). Enhanced de novo collagen type VI (COL VI) formation has been associated with renal fibrosis and CKD. We investigated the hypothesis that PRO-C6, a product specifically generated during COL VI formation, is prognostic for adverse outcomes in patients with type 2 diabetes and microalbuminuria. RESEARCH DESIGN AND METHODS: In a prospective, observational study, we measured PRO-C6 in serum ( S -PRO-C6) and urine (U-PRO-C6) of 198 patients with type 2 diabetes and microalbuminuria without symptoms of coronary artery disease...
April 11, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29628129/comparison-of-the-association-between-high-sensitivity-troponin-i-and-adverse-cardiovascular-outcomes-in-patients-with-versus-without-chronic-kidney-disease
#15
Pratik B Sandesara, Wesley T O'Neal, Ayman Samman Tahhan, Salim S Hayek, Suegene K Lee, Jay Khambhati, Matthew L Topel, Muhammad Hammadah, Ayman Alkhoder, Yi-An Ko, Mohamad Mazen Gafeer, Agim Beshiri, Gillian Murtagh, Jonathan H Kim, Peter Wilson, Leslee Shaw, Stephen E Epstein, Laurence S Sperling, Arshed A Quyyumi
It is unknown whether the association of high-sensitivity troponin I (hs-TnI) with adverse cardiovascular outcomes varies by the presence of chronic kidney disease (CKD). We examined the association of hs-TnI with adverse cardiovascular outcomes in those with and without CKD in 4,107 (mean age, 64 years; 63% men; 20% black) patients from the Emory Cardiovascular Biobank who underwent coronary angiography. CKD (n = 1,073) was defined as estimated glomerular filtration rate <60 ml/min/1.73 m2 or urine albumin/creatinine ratio >30 mg/g at baseline...
March 14, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29605094/predicting-timing-of-clinical-outcomes-in-patients-with-chronic-kidney-disease-and-severely-decreased-glomerular-filtration-rate
#16
Morgan E Grams, Yingying Sang, Shoshana H Ballew, Juan Jesus Carrero, Ognjenka Djurdjev, Hiddo J L Heerspink, Kevin Ho, Sadayoshi Ito, Angharad Marks, David Naimark, Danielle M Nash, Sankar D Navaneethan, Mark Sarnak, Benedicte Stengel, Frank L J Visseren, Angela Yee-Moon Wang, Anna Köttgen, Andrew S Levey, Mark Woodward, Kai-Uwe Eckardt, Brenda Hemmelgarn, Josef Coresh
Patients with chronic kidney disease and severely decreased glomerular filtration rate (GFR) are at high risk for kidney failure, cardiovascular disease (CVD) and death. Accurate estimates of risk and timing of these clinical outcomes could guide patient counseling and therapy. Therefore, we developed models using data of 264,296 individuals in 30 countries participating in the international Chronic Kidney Disease Prognosis Consortium with estimated GFR (eGFR)s under 30 ml/min/1.73m2 . Median participant eGFR and urine albumin-to-creatinine ratio were 24 ml/min/1...
March 24, 2018: Kidney International
https://www.readbyqxmd.com/read/29602632/urinary-biomarkers-of-kidney-tubular-damage-and-risk-of-cardiovascular-disease-and-mortality-in-elders
#17
Vasantha Jotwani, Ronit Katz, Joachim H Ix, Orlando M Gutiérrez, Michael Bennett, Chirag R Parikh, Steven R Cummings, Mark J Sarnak, Michael G Shlipak
RATIONALE & OBJECTIVE: Novel urinary biomarkers have enabled earlier detection of kidney tubular damage, but their prognostic value for adverse cardiovascular outcomes is uncertain. We hypothesized that tubular damage, measured by urine α1 -microglobulin (A1M), amino-terminal propeptide of type III procollagen (PIIINP), and neutrophil gelatinase-associated lipocalin (NGAL), would be associated with higher risks for cardiovascular events and mortality among elders. STUDY DESIGN: Case-cohort study...
March 27, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29590199/the-urine-albumin-creatinine-ratio-is-a-predictor-for-incident-long-term-care-in-a-general-population
#18
Shuko Takahashi, Fumitaka Tanaka, Yuki Yonekura, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Makoto Koshiyama, Akira Okayama, Motoyuki Nakamura
BACKGROUND: Several types of cardiovascular diseases (CVDs) impair the physical and mental status. The purpose of this study was to assess the predictive ability of several cardiovascular biomarkers for identifying the incidence of disability as future recipients of public long-term care (LTC) service. METHODS: The subjects of this study were community-dwelling elderly individuals ≥ 65 years of age without a history of CVD (n = 5,755; mean age, 71 years). The endpoint of this study was official certification as a recipient of LTC...
2018: PloS One
https://www.readbyqxmd.com/read/29589153/an-exploratory-study-of-dapagliflozin-for-the-attenuation-of-albuminuria-in-patients-with-heart-failure-and-type-2-diabetes-mellitus-dapper
#19
Fumiki Yoshihara, Miki Imazu, Toshimitsu Hamasaki, Toshihisa Anzai, Satoshi Yasuda, Shin Ito, Haruko Yamamoto, Kazuhiko Hashimura, Yoshio Yasumura, Kiyoshi Mori, Masataka Watanabe, Masanori Asakura, Masafumi Kitakaze
BACKGROUND AND AIMS: Sodium-dependent glucose transporter-2 (SGLT-2) inhibitors, which are anti-diabetic drugs, reportedly decrease the incidence of cardiovascular events in high-risk patients with cardiovascular diseases, and thus chronic heart failure (CHF). SGLT-2 inhibitors also decrease albuminuria in patients with type 2 diabetes mellitus (T2D). Since albuminuria is a biomarker of not only chronic kidney disease but also cardiovascular events, we hypothesized that, among T2D patients with CHF, SGLT-2 inhibitors will decrease the extent of albuminuria and also improve CHF concomitantly...
March 28, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29579673/associations-between-normal-range-albuminuria-renal-function-and-cardiovascular-function-in-a-population-based-imaging-study
#20
Ilona A Dekkers, Renée de Mutsert, Ton J Rabelink, Johan W Jukema, Albert de Roos, Frits R Rosendaal, Hildo J Lamb, Aiko P J de Vries
BACKGROUND AND AIMS: In patients with impaired renal function and macroalbuminuria, cardiovascular risk factors are highly prevalent, however, whether this is also present in the general population is unclear. We investigated whether normal-range albuminuria and renal function are associated with cardiovascular function in the general population. METHODS: In this cross-sectional analysis of the NEO study, urinary albumin-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and intima-media thickness were assessed in all participants (n = 6503), and a random subset underwent MRI for pulse wave velocity (n = 2451) and/or cardiac imaging (n = 1138)...
March 16, 2018: Atherosclerosis
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