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https://www.readbyqxmd.com/read/28330130/isolation-and-characterization-of-bacterial-endophytes-of-curcuma-longa-l
#1
Ajay Kumar, Ritu Singh, Akhilesh Yadav, D D Giri, P K Singh, Kapil D Pandey
Fourteen endophytic bacterial isolates were isolated from the rhizome of Curcuma longa L. were characterized on the basis of morphology, biochemical characteristics and 16S rRNA gene sequence analysis. The isolates were identified to six strains namely Bacillus cereus (ECL1), Bacillus thuringiensis (ECL2), Bacillus sp. (ECL3), Bacillus pumilis (ECL4), Pseudomonas putida (ECL5), and Clavibacter michiganensis (ECL6). All the strains produced IAA and solubilized phosphate and only two strains produced siderophore (ECL3 and ECL5) during plant growth promoting trait analysis...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28328973/differing-metabolic-responses-to-salt-stress-in-wheat-barley-addition-lines-containing-different-7h-chromosomal-fragments
#2
Eva Darko, Krisztián Gierczik, Orsolya Hudák, Péter Forgó, Magda Pál, Edina Türkösi, Viktória Kovács, Sándor Dulai, Imre Majláth, István Molnár, Tibor Janda, Márta Molnár-Láng
Salinity-induced osmotic, ionic and oxidative stress responses were investigated on Asakaze/Manas wheat/barley addition lines 7H, 7HL and 7HS, together with their barley (salt-tolerant) and wheat (relatively salt-sensitive) parents. Growth, photosynthetic activity, chlorophyll degradation, proline, glycine betaine accumulation, sugar metabolism, Na+ and K+ uptake and transport processes and the role of polyamines and antioxidants were studied in young plants grown in hydroponic culture with or without salt treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28325923/clinical-features-and-viral-quasispecies-characteristics-associated-with-infection-by-the-hepatitis-b-virus-g145r-immune-escape-mutant
#3
Yuan Xue, Ming-Jie Wang, Zhi-Tao Yang, De-Min Yu, Yue Han, Dao Huang, Dong-Hua Zhang, Xin-Xin Zhang
Coexistence of the hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) is an uncommon phenomenon, and the underlying mechanisms remain largely unknown. Amino-acid (aa) substitution from glycine to arginine at aa 145 (G145R), in the major hydrophilic region, has been reported in patients with HBsAg and anti-HBs coexistence. However, there is limited knowledge about the clinical features and viral quasispecies characteristics associated with G145R mutant hepatitis B virus (HBV) infection...
March 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28325734/does-maternal-fetal-transfer-of-creatine-occur-in-pregnant-sheep
#4
Syed Baharom, Robert De Matteo, Stacey Ellery, Paul Della Gatta, Clinton R Bruce, Greg M Kowalski, Nadia Hale, Hayley Dickinson, Richard Harding, David Walker, Rodney J Snow
Our aim was to determine the disposition of creatine in ovine pregnancy, and whether creatine is transferred across the placenta from mother to fetus. Pregnant ewes received either: (i) a continuous intravenous infusion of creatine monohydrate or saline from 122 to 131 days gestation, with maternal and fetal arterial blood and amniotic fluid samples collected daily for creatine analysis and fetal tissues collected at necropsy at 133 days for analysis of creatine content, or; (ii) a single systemic bolus injection of (13)C labelled creatine monohydrate at 130 days of gestation, with maternal and fetal arterial blood, uterine vein blood and amniotic fluid samples collected prior to, and for 4 hours post injection and analysed for creatine, creatine isotopic enrichment, and guanidinoacetic acid (GAA, precursor of creatine) concentrations...
March 21, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28325525/clinical-heterogeneity-of-glycine-encephalopathy-in-three-palestinian-siblings-a-novel-mutation-in-the-glycine-decarboxylase-gldc-gene
#5
Waseem Khraim, Bassam Abu-Libdeh, Suhail Ayesh, Imad Dweikat
INTRODUCTION: Glycine encephalopathy (GE), also known as non-ketotic hyperglycinemia (NKH), is a rare inborn error of glycine metabolism caused by a defect in glycine cleavage system, a multi-enzyme complex located in mitochondrial membrane. This defect results in elevated glycine concentration in plasma and cerebrospinal fluid (CSF). Clinical manifestations vary from severe lethargy, hypoactivity and apneic episodes in the neonatal form, mild or moderate psychomotor delay and seizures in the infantile form, and abnormal behaviors, ataxia and choreoathetoid movements in late onset form...
March 18, 2017: Brain & Development
https://www.readbyqxmd.com/read/28324172/enzymes-involved-in-branched-chain-amino-acid-metabolism-in-humans
#6
REVIEW
María M Adeva-Andany, Laura López-Maside, Cristóbal Donapetry-García, Carlos Fernández-Fernández, Cristina Sixto-Leal
Branched-chain amino acids (leucine, isoleucine and valine) are structurally related to branched-chain fatty acids. Leucine is 2-amino-4-methyl-pentanoic acid, isoleucine is 2-amino-3-methyl-pentanoic acid, and valine is 2-amino-3-methyl-butanoic acid. Similar to fatty acid oxidation, leucine and isoleucine produce acetyl-coA. Additionally, leucine generates acetoacetate and isoleucine yields propionyl-coA. Valine oxidation produces propionyl-coA, which is converted into methylmalonyl-coA and succinyl-coA. Branched-chain aminotransferase catalyzes the first reaction in the catabolic pathway of branched-chain amino acids, a reversible transamination that converts branched-chain amino acids into branched-chain ketoacids...
March 21, 2017: Amino Acids
https://www.readbyqxmd.com/read/28323968/impaired-glycine-mia-in-type-2-diabetes-and-potential-mechanisms-contributing-to-glucose-homeostasis
#7
Richard Yan-Do, Patrick E MacDonald
The onset and/or progression of type 2 diabetes (T2D) can be prevented if intervention is early enough. As such, much effort has been placed on the search for indicators predictive of pre-diabetes and disease onset or progression. An increasing body of evidence suggests that changes in plasma glycine may be one such biomarker. Circulating glycine levels are consistently low in patients with T2D. Levels of this non-essential amino acid correlate negatively with obesity and insulin resistance. Plasma glycine correlates positively with glucose disposal, and rises with interventions such as exercise and bariatric surgery that improve glucose homeostasis...
March 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323618/contact-dependent-killing-by-caulobacter-crescentus-via-cell-surface-associated-glycine-zipper-proteins
#8
Leonor Garcia-Bayona, Monica S Guo, Michael T Laub
Most bacteria are in fierce competition with other species for limited nutrients. Some bacteria can kill nearby cells by secreting bacteriocins, a diverse group of proteinaceous antimicrobials. However, bacteriocins are typically freely diffusible, and so of little value to planktonic cells in aqueous environments. Here, we identify an atypical two-protein bacteriocin in the α-proteobacterium Caulobacter crescentus that is retained on the surface of producer cells where it mediates cell contact-dependent killing...
March 21, 2017: ELife
https://www.readbyqxmd.com/read/28322928/a-temperature-responsive-gene-in-sorghum-encodes-a-glycine-rich-protein-that-interacts-with-calmodulin
#9
Supreet Singh, Amardeep Singh Virdi, Rajdeep Jaswal, Mrinalini Chawla, Sanjay Kapoor, Samar B Mohapatra, Narayanan Manoj, Ashwani Pareek, Sanjay Kumar, Prabhjeet Singh
Imposition of different biotic and abiotic stress conditions results in an increase in intracellular levels of Ca(2+) which is sensed by various sensor proteins. Calmodulin (CaM) is one of the best studied transducers of Ca(2+) signals. CaM undergoes conformational changes upon binding to Ca(2+) and interacts with different types of proteins, thereby, regulating their activities. The present study reports the cloning and characterization of a sorghum cDNA encoding a protein (SbGRBP) that shows homology to glycine-rich RNA-binding proteins...
March 18, 2017: Biochimie
https://www.readbyqxmd.com/read/28322745/role-of-the-small-intestine-colon-and-microbiota-in-determining-the-metabolic-fate-of-polyphenols
#10
REVIEW
Gary Williamson, Michael N Clifford
(Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood. Both the chemical structure of the phenolic moiety and any attached chemical groups define whether the polyphenol is absorbed in the small intestine, or reaches the colon and is subject to extensive catabolism by colonic microbiota. Untransformed substrates may be absorbed, appearing in plasma primarily as methylated, sulfated and glucuronidated derivatives, with in some cases the unchanged substrate...
March 16, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28321006/genetic-characterization-of-soybean-rhizobia-isolated-from-different-ecological-zones-in-north-eastern-afghanistan
#11
Safiullah Habibi, Abdul Ghani Ayubi, Naoko Ohkama-Ohtsu, Hitoshi Sekimoto, Tadashi Yokoyama
Seventy rhizobial isolates were obtained from the root nodules of two soybean (Glycine max) cultivars: Japanese cultivar Enrei and USA cultivar Stine3300, which were inoculated with different soil samples from Afghanistan. In order to study the genetic properties of the isolates, the DNA sequences of the 16S rRNA gene and symbiotic genes (nodD1 and nifD) were elucidated. Furthermore, the isolates were inoculated into the roots of two soybean cultivars, and root nodule numbers and nitrogen fixation abilities were subsequently evaluated in order to assess symbiotic performance...
March 17, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/28320235/methanol-extract-of-nigella-sativa-seed-induces-changes-in-the-levels-of-neurotransmitter-amino-acids-in-male-rat-brain-regions
#12
Tarek El-Naggar, María Emilia Carretero, Carmen Arce, María Pilar Gómez-Serranillos
CONTEXT: Nigella sativa L. (Ranunculaceae) (NS) has been used for medicinal and culinary purposes. Different parts of the plant are used to treat many disorders. OBJECTIVE: This study investigates the effects of NS methanol extract on brain neurotransmitter amino acid levels. MATERIALS AND METHODS: We measured the changes in aspartate, glutamate, glycine and γ-aminobutyric acid in five brain regions of male Wistar rats after methanol extract treatment...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28319841/mesoporous-magnesium-oxide-nanoparticles-derived-via-complexation-combustion-for-enhanced-performance-in-carbon-dioxide-capture
#13
Vishwanath Hiremath, Raghavendra Shavi, Jeong Gil Seo
Magnesium oxide (MgO) is a promising candidate for carbon dioxide (CO2) capture at high temperature applicable to pre-combustion capture in an integrated gasification combined cycle (IGCC) scheme. In this work, mesoporous MgO nanoparticles were synthesized via simple complexation-combustion method by using glycine (G) and urea (U) as fuels (F). The obtained sorbents were thoroughly characterized in terms of the crystalline structure, morphology, nature of the fuel, F/O ratio, and their consequent effects on CO2 sorption...
March 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28318835/improvement-in-mismatch-negativity-generation-during-d-serine-treatment-in-schizophrenia-correlation-with-symptoms
#14
Joshua T Kantrowitz, Michael L Epstein, Migyung Lee, Nayla Lehrfeld, Karen A Nolan, Constance Shope, Eva Petkova, Gail Silipo, Daniel C Javitt
BACKGROUND: Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to symptoms and cognitive dysfunction in schizophrenia. The efficacy of NMDAR agonists in the treatment of persistent symptoms of schizophrenia has been variable, potentially reflecting limitations in functional target engagement. We recently demonstrated significant improvement in auditory mismatch negativity (MMN) with once-weekly treatment with d-serine, a naturally occurring NMDAR glycine-site agonist. This study investigates effects of continuous (daily) NMDAR agonists in schizophrenia/schizoaffective disorder...
March 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28317339/identification-of-a-novel-allele-hla-b-15-01-23-in-a-platelet-donor-by-sequence-based-typing
#15
J-P Li, X-F Li, X Zhang, F-Q Lin, K-L Zhang
HLA-B*15:01:23 has 1 synonymous nucleotide change from HLA-B*15:01:01:01 at nucleotide 393 (codon 107 glycine).
March 19, 2017: HLA
https://www.readbyqxmd.com/read/28314115/genome-wide-identification-and-evolution-of-the-pin-formed-pin-gene-family-in-glycine-max
#16
Yuan Liu, Haichao Wei
Soybean is one of the most important crop plants, wild and cultivated soybean varieties have significant differences worth further investigation, such as plant morphology, seed size, seed coat development, these characters may be related to auxin biology. The PIN family is an essential auxin polar transport gene, but little research on soybean PINs (GmPINs) has been done, especially with respect to evolution and the differences between wild and cultivated soybean. In this study, we retrieved 23 GmPINs from the latest updated G...
March 17, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28314050/efficacy-of-rna-interference-knockdown-using-aerosolized-short-interfering-rnas-bound-to-nanoparticles-in-three-diverse-aphid-species
#17
M W Thairu, I H Skidmore, R Bansal, E Nováková, T E Hansen, H Li-Byarlay, S A Wickline, A K Hansen
RNA interference (RNAi) has emerged as a promising method for validating gene function; however, its utility in nonmodel insects has proven problematic, with delivery methods being one of the main obstacles. This study investigates a novel method of RNAi delivery in aphids, the aerosolization of short interfering RNA (siRNA)-nanoparticle complexes. By using nanoparticles as a siRNA carrier, the likelihood of cellular uptake is increased, when compared to methods previously used in insects. To determine the efficacy of this RNAi delivery system, siRNAs were aerosolized with and without nanoparticles in three aphid species: Acyrthosiphon pisum, Aphis glycines and Schizaphis graminum...
March 17, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28306573/redefining-progressive-encephalomyelitis-with-rigidity-and-myoclonus-after-the-discovery-of-antibodies-to-glycine-receptors
#18
Sarah J Crisp, Bettina Balint, Angela Vincent
PURPOSE OF REVIEW: This review highlights the recent discovery of antibodies to glycine receptor (GlyR-Ab) and discusses the relationship between these antibodies and neurological disorders. RECENT FINDINGS: Since the initial description in 2008 of antibodies to glycine receptors (GlyR-Abs) in a patient with progressive encephalomyelitis with rigidity and myoclonus (PERM), these antibodies have been found in PERM and in some patients with a variety of stiff person spectrum (SPS) or related disorders...
March 16, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28302935/factor-x-deficiency-with-heterozygous-mutations-of-novel-p-g435s-and-known-p-g244r-in-a-patient-presenting-with-severe-umbilical-hemorrhage
#19
Yoko Matsuo, Tatsuki Mizuochi, Miho Mitsuo, Shinichiro Nakagawa, Shuichi Ozono, Koichiro Ueda, Yoko Sogabe, Ritsuko Seki, Kenji Soejima, Takashi Okamura, Yushiro Yamashita
A 10-day-old male patient was referred to our hospital with severe umbilical bleeding. Prothrombin time (PT) and activated partial thromboplastin time (APTT) were prominently prolonged. Plasma coagulation factor X (FX) activity and antigen levels were 1% and 0.6%, respectively. A DNA sequence analysis of his leukocytes revealed a compound heterozygous state; known Gly244 to Arg (p.G244R) in exon 6 and a novel mutation of Gly 435 to Ser (p.G435S) in exon 8. A pedigree analysis showed that p.G244R originated from the paternal side, while p...
March 15, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/28302785/genome-sequence-of-cluster-w-mycobacteriophage-taptic
#20
Catherine M Mageeney, Emily R Seier, Elise C Esposito, Lee H Graham, Emily L Heckman, Chelsea M Hipwell, Allison B Kelliher, Nicole A Lando, Patricia Y Morales, Daniel A Russell, Barbara E Tsaousis, Margaret A Kenna, Vassie C Ware
The Taptic genome is the first to be annotated from the W cluster of mycobacteriophages infecting Mycobacterium smegmatis mc(2)155. All 92 predicted open reading frames (ORFs) and a single tRNA specifying glycine (tRNA-gly) are transcribed rightward. Many functionally uncharacterized ORFs appear to be W cluster specific, as nucleotide similarity is shared only with other W cluster genomes.
March 16, 2017: Genome Announcements
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