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Asthma exacerbations

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https://www.readbyqxmd.com/read/28926373/exposure-to-mobile-source-air-pollution-in-early-life-and-childhood-asthma-incidence-the-kaiser-air-pollution-and-pediatric-asthma-study
#1
Audrey Flak Pennington, Matthew J Strickland, Mitchel Klein, Xinxin Zhai, Josephine T Bates, Carolyn Drews-Botsch, Craig Hansen, Armistead G Russell, Paige E Tolbert, Lyndsey A Darrow
BACKGROUND: Early-life exposure to traffic-related air pollution exacerbates childhood asthma, but it is unclear what role it plays in asthma development. METHODS: The association between exposure to primary mobile source pollutants during pregnancy and during infancy and asthma incidence by ages 2 through 6 was examined in the Kaiser Air Pollution and Pediatric Asthma Study, a racially diverse birth cohort of 24,608 children born between 2000 and 2010 and insured by Kaiser Permanente Georgia...
September 18, 2017: Epidemiology
https://www.readbyqxmd.com/read/28925861/perioperative-pulmonary-medication-management
#2
Johnathan Ross Renew, Stephen Aniskevich
BACKGROUND: Pulmonary conditions such as asthma and chronic obstructive pulmonary disease (COPD) are common conditions that warrant special consideration in the perioperative period. When these patients undergo surgical interventions, they have risk of complications such as bronchospasm, hypoxia, and even postoperative respiratory failure that warrants unplanned intensive care unit admission. Thus, clinicians must be familiar with pulmonary medication regimens that are critical for maintaining stable homeostasis of these chronic conditions...
September 18, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28925663/top-poems-of-2016-consistent-with-the-principles-of-the-choosing-wisely-campaign
#3
Roland Grad, Mark H Ebell
A challenge in the Choosing Wisely campaign is to identify low-value clinical actions supported by high-quality evidence. We applied a method based on crowdsourcing the Daily POEM (patient-oriented evidence that matters) to identify low-value clinical actions from research studies consistent with the principles of Choosing Wisely. In 2016, we analyzed an average of 1,382 questionnaires on 265 unique POEMs delivered to physician members of the Canadian Medical Association. From these questionnaires, we identified the POEMs ranking highest on one questionnaire item directly linked to reducing overdiagnosis or overtreatment...
August 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925525/determinants-of-low-risk-of-asthma-exacerbation-during-pregnancy
#4
Zarqa Ali, Lisbeth Nilas, Charlotte Suppli Ulrik
BACKGROUND: Assessment of asthma control every 4-6 weeks during pregnancy is recommended to reduce risk of exacerbation, and by that improve outcome. OBJECTIVE: To identify determinants of pregnancies with low risk of asthma exacerbation. METHODS: All pregnant women enrolled into the Management of Asthma during Pregnancy (MAP) program at Hvidovre Hospital since 2007. Assessment of asthma control, adjustment of treatment, spirometry and measurement of exhaled nitric oxide (FE NO) were performed, and baseline characteristics and exacerbation history was collected at enrolment...
September 19, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28923762/translating-basic-research-into-clinical-practice-vitamin-d-in-asthma-mechanisms-of-action-and-considerations-for-clinical-trials
#5
REVIEW
Paul E Pfeffer, Catherine M Hawrylowicz
There is increasing interest in the therapeutic utility of vitamin D in asthma, supported by a significant body of evidence on epidemiological associations between vitamin D insufficiency and worse asthma control. In support of a causal relationship, vitamin D beneficially modulates diverse immunological pathways in heterogeneous asthma endotypes, regulating the actions of lymphocytes, mast cells, antigen-presenting cells and structural cells to dampen excessive inflammatory responses. Allergic asthma is characterised by a failure of immune tolerance, and development of pathological responses to inhaled aeroallergens, and vitamin D has been extensively shown to support immune regulation...
September 15, 2017: Chest
https://www.readbyqxmd.com/read/28919200/predictors-of-enhanced-response-with-benralizumab-for-patients-with-severe-asthma-pooled-analysis-of-the-sirocco-and-calima-studies
#6
J Mark FitzGerald, Eugene R Bleecker, Andrew Menzies-Gow, James G Zangrilli, Ian Hirsch, Paul Metcalfe, Paul Newbold, Mitchell Goldman
BACKGROUND: Benralizumab is an anti-eosinophilic, anti-interleukin-5 receptor α monoclonal antibody that has been shown to significantly reduce asthma exacerbations and improve lung function for patients with severe, uncontrolled asthma. We further explored the efficacy of benralizumab for patients with different baseline blood eosinophil thresholds and exacerbation histories. METHODS: This study is a pooled analysis of the results from the randomised, double-blind, placebo-controlled SIROCCO (NCT01928771) and CALIMA (NCT01914757) phase 3 studies...
September 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28915873/a-prospective-cohort-study-on-ambient-air-pollution-and-respiratory-morbidities-including-childhood-asthma-in-adolescents-from-the-western-cape-province-study-protocol
#7
Toyib Olaniyan, Mohamed Jeebhay, Martin Röösli, Rajen Naidoo, Roslynn Baatjies, Nino Künzil, Ming Tsai, Mark Davey, Kees de Hoogh, Dilys Berman, Bhawoodien Parker, Joy Leaner, Mohamed Aqiel Dalvie
BACKGROUND: There is evidence from existing literature that ambient air pollutant exposure in early childhood likely plays an important role in asthma exacerbation and other respiratory symptoms, with greater effect among asthmatic children. However, there is inconclusive evidence on the role of ambient air pollutant exposures in relation to increasing asthma prevalence as well as asthma induction in children. At the population level, little is known about the potential synergistic effects between pollen allergens and air pollutants since this type of association poses challenges in uncontrolled real life settings...
September 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28913992/effects-of-immunoglobulin-replacement-on-asthma-exacerbation-in-adult-asthmatics-with-igg-subclass-deficiency
#8
Joo Hee Kim, Young Min Ye, Ga Young Ban, Yoo Seob Shin, Hyun Young Lee, Young Hee Nam, Soo Keol Lee, You Sook Cho, Seung Hun Jang, Ki Suck Jung, Hae Sim Park
PURPOSE: Recurrent respiratory tract infection is a common manifestation of primary immunodeficiency disease, and respiratory viruses or bacteria are important triggers of asthma exacerbations. Asthma often coexists with humoral immunodeficiency in adults, and some asthmatics with immunoglobulin (Ig) G subclass deficiency (IgGSCD) suffer from recurrent exacerbations. Although some studies suggest a benefit from Ig replacement, others have failed to support its use. This study aimed to assess the effect of Ig replacement on asthma exacerbation caused by respiratory infection as well as the asthma control status of adult asthmatics with IgGSCD...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28913991/seasonal-cycle-and-relationship-of-seasonal-rhino-and-influenza-virus-epidemics-with-episodes-of-asthma-exacerbation-in-different-age-groups
#9
Seung Won Lee, Shinhae Lee, Youn Ho Sheen, Eun Kyo Ha, Sun Hee Choi, Min Suk Yang, Sohyun Hwang, Sung Soon Kim, Jang Hoon Choi, Man Yong Han
PURPOSE: Seasonal variations in asthma exacerbation (AE) are associated with respiratory virus outbreaks and the return of children to school after vacation. This study aims to elucidate the period, phase, and amplitude of seasonal cycles of AE in 5 different age groups with regard to rhino- and influenza virus epidemics in Korea. METHODS: The number of daily emergency department (ED) visits for AE in all age groups of Korea and the nationwide weekly incidence of rhino- and influenza virus, were obtained for 2008-2012...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28913988/prevalence-of-respiratory-viral-infections-in-korean-adult-asthmatics-with-acute-exacerbations-comparison-with-those-with-stable-state
#10
Ki Hyun Seo, Da Jeong Bae, Ji Na Kim, Ho Sung Lee, Yong Hoon Kim, Jong Sook Park, Myung Shin Kim, Hun Soo Chang, Ji Hye Son, Dong Gyu Baek, Jun Suk Lee, Choon Sik Park
PURPOSE: Viral infections are involved in ~50% of exacerbations among Caucasian adult asthmatics. However, there have been few reports on the causative virus of exacerbations in Korean adult asthmatics. Thus, we compared frequencies and types of viruses between lower respiratory tract illnesses (LRTIs) with exacerbations (exacerbated LRTIs) and those without exacerbations (stable LRTIs) to evaluate contribution of respiratory viruses to exacerbations. METHODS: Viral RNA was extracted from sputum using the Viral Gene-spin™ Kit...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28913987/clinical-characteristics-of-exacerbation-prone-adult-asthmatics-identified-by-cluster-analysis
#11
Mi Ae Kim, Seung Woo Shin, Jong Sook Park, Soo Taek Uh, Hun Soo Chang, Da Jeong Bae, You Sook Cho, Hae Sim Park, Ho Joo Yoon, Byoung Whui Choi, Yong Hoon Kim, Choon Sik Park
PURPOSE: Asthma is a heterogeneous disease characterized by various types of airway inflammation and obstruction. Therefore, it is classified into several subphenotypes, such as early-onset atopic, obese non-eosinophilic, benign, and eosinophilic asthma, using cluster analysis. A number of asthmatics frequently experience exacerbation over a long-term follow-up period, but the exacerbation-prone subphenotype has rarely been evaluated by cluster analysis. This prompted us to identify clusters reflecting asthma exacerbation...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28913984/effective-strategies-for-managing-asthma-exacerbations-for-precision-medicine
#12
EDITORIAL
You Sook Cho
No abstract text is available yet for this article.
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28913336/anti-interleukin-5-il-5-and-il-5ra-biological-drugs-efficacy-safety-and-future-perspectives-in-severe-eosinophilic-asthma
#13
REVIEW
Diego Bagnasco, Matteo Ferrando, Gilda Varricchi, Francesca Puggioni, Giovanni Passalacqua, Giorgio Walter Canonica
The definition of asthma has changed considerably in recent years, to the extent that asthma is no longer considered a single disease but a heterogeneous disorder that includes several phenotypes and, possibly, endotypes. A more detailed analysis of the immunological mechanisms underlying the pathogenesis of asthma shows interleukin 5 (IL-5) to be a crucial cytokine in several asthma phenotypes. In fact, IL-5 exerts selective action on eosinophils, which, in turn, sustain airway inflammation and worsen asthma symptoms and control...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28912783/sex-differences-in-asthma-a-key-role-of-androgen-signaling-in-group-2-innate-lymphoid-cells
#14
REVIEW
Sophie Laffont, Eve Blanquart, Jean-Charles Guéry
Infectious diseases, autoimmune diseases, and also allergy differentially affect women and men. In general, women develop strongest immune responses and thus the proportion of infected individuals and the severity of many viral, bacterial, or parasitic infections are increased in men. However, heightened immunity in women makes them more susceptible than men to autoimmunity and allergy. While sex differences in immunity are well documented, little is known about the cellular and molecular mechanisms underlying these immunological differences, particularly in allergic asthma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28903951/managing-problematic-severe-asthma-beyond-the-guidelines
#15
REVIEW
Katharine C Pike, Mark L Levy, John Moreiras, Louise Fleming
This review discusses issues related to managing problematic severe asthma in children and young people. A small minority of children have genuinely severe asthma symptoms which are difficult to control. Children with genuinely severe asthma need investigations and treatments beyond those described within conventional guidelines. However, the majority of children with poor symptom control despite high-intensity treatment achieve improvement in their asthma control once attention has been paid to the basics of asthma management...
September 13, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28894957/efficacy-of-a%C3%A2-multidisciplinary-pulmonary-rehabilitation-outpatient-program-on-exacerbations-in-overweight-and-obese-patients-with-asthma
#16
Ipek Candemir, Pinar Ergun, Dicle Kaymaz
BACKGROUND: Even though many studies have investigated the effectiveness of weight loss interventions, the efficacy of pulmonary rehabilitation (PR) has not yet been proven in obese patients with asthma. The aims of this study were to investigate the efficacy of PR on asthma exacerbations in the first year after PR and to evaluate the efficacy of PR in exercise capacity, quality of life, psychosocial symptoms and control of asthma in overweight patients. METHODS: The exercise capacity, health-related quality of life scores, psychosocial symptoms, asthma control test (ACT) data, number of emergency admissions and hospitalizations of 35 overweight patients with asthma who completed a 1-year multidisciplinary PR program were recorded and analyzed...
September 11, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28892418/shared-decision-making-and-time-to-exacerbation-in-children-with-asthma
#17
Tsai-Ling Liu, Yhenneko J Taylor, Rohan Mahabaleshwarkar, Christopher M Blanchette, Hazel Tapp, Michael F Dulin
BACKGROUND: Although shared decision making (SDM) is a promising approach for improving outcomes for patients with chronic diseases, no evidence currently supports the use of SDM to delay asthma exacerbations. We evaluated the impact of an SDM intervention implemented by providers in a real-world setting on time to exacerbation in children with asthma. METHODS: This study used a prospective cohort observed between 2011-2013 at five primary care practices that serve vulnerable populations (e...
September 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28889999/humoral-immune-responses-during-asthma-and-influenza-co-morbidity-in-mice
#18
Laura A Doorley, Kim S LeMessurier, Amy R Iverson, Maneesha Palipane, Amali E Samarasinghe
Humoral immunity serve dual functions of direct pathogen neutralization and enhancement of leukocyte function. Antibody classes are determined by antigen triggers, and the resulting antibodies can contribute to disease pathogenesis and host defense. Although asthma and influenza are immunologically distinct diseases, since we have found that allergic asthma exacerbation promotes antiviral host responses to influenza A virus, we hypothesized that humoral immunity may contribute to allergic host protection during influenza...
September 7, 2017: Immunobiology
https://www.readbyqxmd.com/read/28889953/role-of-b-cells-in-t-helper-cell-responses-in-a-mouse-model-of-asthma
#19
Tomasz Piotr Wypych, Roberta Marzi, Gregory F Wu, Antonio Lanzavecchia, Federica Sallusto
BACKGROUND: The importance of B lymphocytes to present antigens for antibody production is well documented. In contrast, very little is known about their capacity to influence CD4(+) T cell activation during primary or secondary response to allergens. OBJECTIVE: Using mouse models of asthma, we investigated the role of B cells as antigen presenting cells in propagation and initiation of T helper cell responses. METHODS: Mice were immunized via intranasal route with house dust mite extract (HDM) derived from Dermatophagoides pteronyssinus...
September 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28889067/immune-monitoring-for-precision-medicine-in-allergy-and-asthma
#20
REVIEW
Scott Dexter Boyd, Ramona Amy Hoh, Kari Christine Nadeau, Stephen Joseph Galli
'Precision Medicine' embodies the analyses of extensive data collected from patients and their environments to identify and apply patient-specific prophylactic strategies and medical treatments to improve clinical outcomes and healthcare cost-effectiveness. Many new methods have been developed for evaluating the activity of the human immune system. Such 'immune monitoring' approaches are now being used in studies of allergy and asthma in the hope of identifying better correlates of disease status, predictors of therapeutic outcomes, and potential side-effects of treatment...
September 6, 2017: Current Opinion in Immunology
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