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Multiple sclerosis and gluten

Leah J Mische, Ellen M Mowry
PURPOSE OF REVIEW: This review aims to critically evaluate published studies examining diets and nutritional supplements (excepting vitamin D) for the impact on prevention and prognosis of multiple sclerosis (MS). RECENT FINDINGS: There is a negative relationship between the Mediterranean diet and vascular disease, and vascular co-morbidities are associated with a worse MS prognosis. Low-fat, fish-based diets, sodium-restricted diets, calorie restriction, the paleo diet, and gluten-free diets have been examined, mostly in observational studies; results are inconclusive...
March 17, 2018: Current Treatment Options in Neurology
Hiroshi Mitoma, Mario Manto, Christiane S Hampe
The cerebellum characteristically has the capacity to compensate for and restore lost functions. These compensatory/restorative properties are explained by an abundant synaptic plasticity and the convergence of multimodal central and peripheral signals. In addition, extra-cerebellar structures contribute also to the recovery after a cerebellar injury. Clinically, some patients show remarkable improvement of severe ataxic symptoms associated with trauma, stroke, metabolism, or immune-mediated cerebellar ataxia (IMCA, e...
February 19, 2018: Cerebellum
Massimiliano Cristofanilli, Daniel Gratch, Benjamin Pagano, Kelsey McDermott, Jessie Huang, Jeffrey Jian, Deneb Bates, Saud A Sadiq
BACKGROUND: Transglutaminase-6 (TGM6), a member of the transglutaminase enzyme family, is found predominantly in central nervous system (CNS) neurons under physiological conditions. It has been proposed as an autoimmune target in cerebral palsy, gluten-sensitive cerebellar ataxia, and schizophrenia. OBJECTIVE: To investigate TGM6 involvement in multiple sclerosis (MS). METHODS: Antibody levels against TGM6 (TGM6-IgG) were measured in the cerebrospinal fluid (CSF) of 62 primary progressive multiple sclerosis (PPMS), 85 secondary progressive multiple sclerosis (SPMS), and 50 relapsing-remitting multiple sclerosis (RRMS) patients and 51 controls...
December 1, 2016: Multiple Sclerosis: Clinical and Laboratory Research
Giovanni Casella, Bianca M Bordo, Renzo Schalling, Vincenzo Villanacci, Marianna Salemme, Camillo DI Bella, Vittorio Baldini, Gabrio Bassotti
Celiac Disease (CD) determins Neurologic Manifestations in 10% of all CD patients. We describe the most common clinical manifestations as Cerebellar Ataxia, Gluten Encephalopathy, Multiple Sclerosis, Peripheral Neuropathies, SensoriNeural Hearing Loss, Epilepsy, Headache, Depression, Cognitive Deficiencies and other less decribed clinical conditions. Our aim is to perform, as more as possible, a review about the most recent update on the topics in international literature. It is important to consider clinical neurological manifestations in Celiac patients and to research these conditions also in the follow- up because they may start also 1 year after the start of Gluten Free Diet (GFD) as Peripheral Neuropathy...
April 6, 2016: Minerva Gastroenterologica e Dietologica
Giovanni Casella, Bianca M Bordo, Renzo Schalling, Vincenzo Villanacci, Marianna Salemme, Camillo Di Bella, Vittorio Baldini, Gabrio Bassotti
Celiac disease (CD) determines neurologic manifestations in 10% of all CD patients. We describe the most common clinical manifestations as cerebellar ataxia, gluten encephalopathy, multiple sclerosis, peripheral neuropathies, sensorineural hearing loss, epilepsy, headache, depression, cognitive deficiencies and other less described clinical conditions. Our aim is to perform, as more as possible, a review about the most recent update on the topics in international literature. It is important to consider clinical neurological manifestations in celiac patients and to research these conditions also in the follow-up because they may start also one year after the start of gluten free diet (GFD) as peripheral neuropathy...
June 2016: Minerva Gastroenterologica e Dietologica
Pål Stenberg, Bodil Roth
UNLABELLED: Post-translational modifications of proteins can generate antigenic conformations that may cause autoimmune diseases in persons with specific HLA-haplotypes. Monocytes and macrophages, attracted to an inflamed site, can release post-translationally acting enzymes, such as transglutaminases and peptidylarginine deiminases. In vivo, the activation of these enzymes is crucial for the further course of event. Our hypothesis is that zinc modulates the activation of these calcium-dependent thiol-enzymes...
April 2015: Medical Hypotheses
Ismael San Mauro Martín, Elena Garicano Vilar, Luis Collado Yurrutia, María José Ciudad Cabañas
INTRODUCTION: Gluten is a glycoprotein present in some cereals. The incidence of disorders related to gluten, including the EC, is increasing, even pathologies far from an etiology or treatment with GF D. AIMS: Review the scientific literature related to the ingestion of gluten and pathogenesis of different diseases. METHODS: A literature search in major scientific database. RESULTS: We obtained from the following diseases, gluten ataxia, multiple sclerosis, autism spectrum disorder, schizophrenia, attention deficit hyperactivity disorder, depressive disorders, headaches, irritable bowel syndrome, fibromyalgia, dermatitis herpetiformis and epilepsy, studies in which either a determination of gliadin was refered or a treatment, with/without gluten, was applied and evaluated...
December 1, 2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Emily G Severance, Kristin L Gressitt, Armin Alaedini, Cathrin Rohleder, Frank Enning, J Malte Bumb, Juliane K Müller, Emanuel Schwarz, Robert H Yolken, F Markus Leweke
Schizophrenia is a complex brain disorder that may be accompanied by idiopathic inflammation. Classic central nervous system (CNS) inflammatory disorders such as viral encephalitis or multiple sclerosis can be characterized by incongruent serum and cerebrospinal fluid (CSF) IgG due in part to localized intrathecal synthesis of antibodies. The dietary antigens, wheat gluten and bovine milk casein, can induce a humoral immune response in susceptible individuals with schizophrenia, but the correlation between the food-derived serological and intrathecal IgG response is not known...
February 2015: Brain, Behavior, and Immunity
Richard E Frye, Daniel Rossignol, Manuel F Casanova, Gregory L Brown, Victoria Martin, Stephen Edelson, Robert Coben, Jeffrey Lewine, John C Slattery, Chrystal Lau, Paul Hardy, S Hossein Fatemi, Timothy D Folsom, Derrick Macfabe, James B Adams
Despite the fact that seizures are commonly associated with autism spectrum disorder (ASD), the effectiveness of treatments for seizures has not been well studied in individuals with ASD. This manuscript reviews both traditional and novel treatments for seizures associated with ASD. Studies were selected by systematically searching major electronic databases and by a panel of experts that treat ASD individuals. Only a few anti-epileptic drugs (AEDs) have undergone carefully controlled trials in ASD, but these trials examined outcomes other than seizures...
September 13, 2013: Frontiers in Public Health
Robert K Naviaux
The cell danger response (CDR) is the evolutionarily conserved metabolic response that protects cells and hosts from harm. It is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis. The resulting metabolic mismatch between available resources and functional capacity produces a cascade of changes in cellular electron flow, oxygen consumption, redox, membrane fluidity, lipid dynamics, bioenergetics, carbon and sulfur resource allocation, protein folding and aggregation, vitamin availability, metal homeostasis, indole, pterin, 1-carbon and polyamine metabolism, and polymer formation...
May 2014: Mitochondrion
H Z Batur-Caglayan, C Irkec, I Yildirim-Capraz, N Atalay-Akyurek, S Dumlu
Objectives. Multiple sclerosis (MS) is an inflammatory autoimmune disorder of the central nervous system (CNS). Since a correlation between gluten intake and incidence of MS had been reported, the relationship of antigliadin antibodies and MS was debated. Case Report. We report the case of a 45-year-old female MS patient who is under interferon treatment. After seven years of monitoring, during her routine gastroenterological assessment, she was diagnosed with celiac disease. Conclusion. Beside the neurological manifestations that have been demonstrated in about 10% of celiac disease (CD) patients, white-matter abnormalities in brain MRI are uncommon and controversial...
2013: Case Reports in Neurological Medicine
Francesca Megiorni, Antonio Pizzuti
Celiac disease (CD) is a multifactorial disorder with an estimated prevalence in Europe and USA of 1:100 and a female:male ratio of approximately 2:1. The disorder has a multifactorial etiology in which the triggering environmental factor, the gluten, and the main genetic factors, Human Leukocyte Antigen (HLA)-DQA1 and HLA-DQB1 loci, are well known. About 90-95% of CD patients carry DQ2.5 heterodimers, encoded by DQA1*05 and DQB1*02 alleles both in cis or in trans configuration, and DQ8 molecules, encoded by DQB1*03:02 generally in combination with DQA1*03 variant...
2012: Journal of Biomedical Science
Gloria von Geldern, Ellen M Mowry
The effect of nutrition and dietary supplements on the course of multiple sclerosis (MS) is a topic of great interest to both patients and clinicians. In particular, vitamin D status has been shown to influence both the incidence and the course of MS. High vitamin D levels are probably protective against the development of MS, although the efficacy of vitamin D supplementation in slowing progression of MS remains to be established. The influence of polyunsaturated fatty acids (PUFAs) on the development and course of MS has also long been under investigation...
December 2012: Nature Reviews. Neurology
Carlos Hernández-Lahoz, Luis Rodrigo
Gluten-related disorders are a spectrum of systemic immune mediated conditions that occur at any age in genetically susceptible individuals upon ingesting gluten. Celiac disease and gluten sensitivity are the most important conditions of the spectrum. They may be associated with other autoimmune diseases, such as multiple sclerosis and neuromyelitis optica. Treatment with a gluten-free diet can provide considerable benefits to the patients having both a gluten-related disorder and one of these 2 demyelinating diseases of the central nervous system...
April 15, 2013: Medicina Clínica
Shuo-Wang Qiao, Rasmus Iversen, Melinda Ráki, Ludvig M Sollid
Compared to other human leukocyte antigen (HLA)-associated diseases such as type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, fundamental aspects of the pathogenesis in celiac disease are relatively well understood. This is mostly because the causative antigen in celiac disease-cereal gluten proteins-is known and the culprit HLA molecules are well defined. This has facilitated the dissection of the disease-relevant CD4+ T cells interacting with the disease-associated HLA molecules. In addition, celiac disease has distinct antibody responses to gluten and the autoantigen transglutaminase 2, which give strong handles to understand all sides of the adaptive immune response leading to disease...
July 2012: Seminars in Immunopathology
Luis Rodrigo, Carlos Hernández-Lahoz, Dolores Fuentes, Noemí Alvarez, Antonio López-Vázquez, Segundo González
BACKGROUND: Celiac disease (CD) is a common systemic disease related to a permanent intolerance to gluten and is often associated with different autoimmune and neurological diseases. Its mean prevalence in the general population is 1-2% worldwide. Our aim was to study the prevalence of celiac disease in a prospective series of Multiple Sclerosis (MS) patients and their first-degree relatives. METHODS: We analyzed the prevalence of serological, histological and genetic CD markers in a series of 72 MS patients and in their 126 first-degree relatives, compared to 123 healthy controls...
2011: BMC Neurology
Dana Ben-Ami Shor, Ori Barzilai, Maya Ram, David Izhaky, Bat Sheva Porat-Katz, Joab Chapman, Miri Blank, Juan-Manuel Anaya, Yehuda Shoenfeld
Patients with neurological disease of unknown etiology sometimes present with antigliadin and antitissue transglutaminase antibodies. The association between these antibodies and multiple sclerosis has been previously suggested. The purpose of this study was to determine the prevalence of these antibodies in multiple sclerosis patients. We determined the level of serum immunoglobulin A and immunoglobulin G antigliadin and antitissue transglutaminase antibodies in 98 patients with multiple sclerosis. We found a highly significant increase in titers of immunoglobulin G antibodies against gliadin and tissue transglutaminase in the multiple sclerosis patients...
September 2009: Annals of the New York Academy of Sciences
E M Leong, S J Semple, M Angley, W Siebert, J Petkov, R A McKinnon
OBJECTIVES: To investigate the usage patterns of complementary and alternative medicines (CAMs), as well as dietary interventions, by South Australian people with multiple sclerosis (MS). DESIGN: Self-administered postal survey. SETTING: Questionnaire mailed to recipients of the South Australian (SA) MS Society newsletter (n=1230). MAIN OUTCOME MEASURES: Patterns of CAMs use and dietary interventions, reasons for using/not using CAMs in MS, sources of CAMs information and monthly expenditure on CAMs/dietary interventions...
August 2009: Complementary Therapies in Medicine
Giovanni Frisullo, Viviana Nociti, Raffaele Iorio, Agata Katia Patanella, Alessandro Marti, Giovanni Cammarota, Massimiliano Mirabella, Pietro Attilio Tonali, Anna Paola Batocchi
Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls...
December 2008: Human Immunology
Maria Teresa Ferrò, Diego Franciotta, Tommaso Riccardi, Elisabetta D'Adda, Elsa Mainardi, Alessandro Montanelli
Multiple sclerosis (MS) and coeliac disease (CD) are an uncommon association. Recently "MS-like illness and CNS white-matter abnormalities" have been demonstrated in patients with CD. We report the case of a 19-year-old female with MS, who presented an episode of headache at onset of disease and developed acute hepatitis (AH) 14 months later. After the diagnosis of AH, an occult CD, confirmed by jejunal biopsy, was disclosed. Constipation was the only gastrointestinal symptom. A serum sample collected before onset of MS was positive for CD...
February 2008: Neurological Sciences
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