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https://www.readbyqxmd.com/read/29787036/reflections-of-a-black-african-insider-researcher
#1
Isaac Tuffour
BACKGROUND: There is a growing body of literature providing reflective accounts and critical examination of the challenges faced by insider researchers. However, there is little research about the specific challenges that black African insider nurse researchers face. AIM: To reflect on the complexities black African insider nurse researchers face in the context of research sites, participants and the interpretation of data. DISCUSSION: Insider researchers are susceptible to various entanglements and dilemmas...
May 22, 2018: Nurse Researcher
https://www.readbyqxmd.com/read/29785447/posterior-cortical-breakage-leads-to-posterior-tibial-slope-change-in-lateral-hinge-fracture-following-opening-wedge-high-tibial-osteotomy
#2
Sung-Sahn Lee, Kyung-Wook Nha, Dae-Hee Lee
PURPOSE: This study was designed to analyze the relationship between changes in posterior tibial slope and the absence or presence of lateral hinge fracture, diagnosed in the sagittal and axial planes, as well as the coronal plane, by computed tomography (CT) following opening wedge high tibial osteotomy (HTO). METHODS: This study involved 55 patients (55 knees) undergoing opening wedge HTO for primary medial osteoarthritis. Lateral hinge fractures were evaluated on CT scans according to the Takeuchi classification and were also classified as subtypes A, B, and C, depending on anterior, posterior, and both anterior and posterior cortical disruptions, respectively, as determined by the sagittal and axial planes of CT scans which corresponded to the fracture line visible on coronal CT scans...
May 21, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29785044/the-live-cell-dna-stain-sir-hoechst-induces-dna-damage-responses-and-impairs-cell-cycle-progression
#3
Onur Sen, Adrian T Saurin, Jonathan M G Higgins
SiR-Hoechst (SiR-DNA) is a far-red fluorescent DNA probe being used widely for time-lapse imaging of living cells that is reported to be minimally toxic at concentrations as high as 10-25 µM. However, measuring nuclear import of Cyclin B1, inhibition of mitotic entry, and the induction of γH2AX foci in cultured human cells reveals that SiR-Hoechst induces DNA damage responses and G2 arrest at concentrations well below 1 µM. SiR-Hoechst is useful for live cell imaging, but it should be used with caution and at the lowest practicable concentration...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784553/postural-orthostatic-tachycardia-syndrome-during-pregnancy-a-systematic-review-of-the-literature
#4
REVIEW
Kate Morgan, Catherine Chojenta, Meredith Tavener, Angela Smith, Deb Loxton
PURPOSE: Postural Orthostatic Tachycardia Syndrome is most commonly seen in women of child bearing age, however little is known about its effects in pregnancy. METHOD: A systematic review was conducted in March 2015 and updated in February 2018. Medline, Embase, PsychInfo, CINHAL, and the Cochrane Library were searched from database inception. The ClinicalTrials.gov site and bibliographies were searched. MeSH and Emtree headings and keywords included; Postural Orthostatic Tachycardia Syndrome, Postural Tachycardia Syndrome, and were combined with pregnancy and pregnancy related subject headings and keywords...
May 9, 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29784250/update-on-pediatric-onset-multiple-sclerosis
#5
REVIEW
A Ruet
Pediatric-onset multiple sclerosis (POMS) has distinctive features compared with adult-onset multiple sclerosis (AOMS), and warrants caution despite being a rare form of MS. POMS diagnostic criteria are somewhat different from those used in AOMS, with acute disseminated encephalomyelitis being a key differential diagnosis of MS in children. Other differential diagnoses that have to be ruled out before diagnosing MS include demyelinating syndromes, autoimmune and systemic pathologies, and infectious, genetic, metabolic and neoplastic diseases...
May 18, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29782805/maintaining-supersaturation-of-nimodipine-by-pvp-with-or-without-the-presence-of-sodium-lauryl-sulfate-and-sodium-taurocholate
#6
Yipshu Pui, Yuejie Chen, Huijun Chen, Shan Wang, Chengyu Liu, Wouter Tonnis, Linc Chen, Peter Serno, Stefan Bracht, Feng Qian
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery system to improve the dissolution rate and oral bioavailability of poorly water soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been marketed and effectively used in clinic for nearly 30 years, yet the mechanism by which PVP maintains the supersaturation and subsequently improves the bioavailability of NMD was rarely investigated. In this research, we first studied the molecular interactions between NMD and PVP by solution NMR using CDCl3 as the solvent, and drug-polymer Flory-Huggins interaction parameter...
May 21, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29782693/multidomain-intervention-for-the-prevention-of-cognitive-decline-after-stroke-a-pooled-patient-level-data-analysis
#7
Yvonne Teuschl, Hege Ihle-Hansen, Karl Matz, Alexandra Dachenhausen, Paulina Ratajczak, Jaakko Tuomilehto, Marie Helene Ursin, Guri Hagberg, Bente Thommessen, Anne Rita Øksengård, Michael Brainin
BACKGROUND: The aim of this pooled patient-level data analysis was to test if multidomain interventions, addressing several modifiable vascular risk factors simultaneously, is more effective than usual post-stroke care for the prevention of cognitive decline after stroke. METHODS: This pooled patient-level data analysis includes two randomised controlled trials using a multidomain approach to target vascular risk factors in stroke patients and cognition as primary outcome...
May 21, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29781371/quantification-of-tantalum-sedimentation-rates-in-liquid-embolic-agents
#8
J R Mason, C Dodge, G Benndorf
Background Endovascular treatment (EVT) of brain arteriovenous malformations has evolved from cyanoacrylate derivatives such as N-butyl cyanoacrylate, an adhesive glue, to ethylene vinyl copolymer-based liquid embolics such as Onyx® and SQUID® dissolved in dimethyl sulfoxide. Although these agents offer several advantages, their rapidly decreasing radiopacity, as a result of the sedimentation of tantalum powder, compromises visual control during EVT. This study aims to quantify and compare tantalum sedimentation rates of several liquid embolic agents, and determine their effects on radiopacity...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29781200/the-efficacy-of-emotionally-focused-couples-therapy-and-behavioral-couples-therapy-a-meta-analysis
#9
Maren Rathgeber, Paul-Christian Bürkner, Eva-Maria Schiller, Heinz Holling
Behavioral couple therapy (BCT) and emotionally focused couples therapy (EFCT) are well-established treatments to reduce couple distress. This meta-analysis summarizes the current state of knowledge on the efficacy of these two therapy methods by focusing on randomized controlled trials only. A literature search revealed 33 suitable primary studies (2,730 participants in total), all of them measuring relationship satisfaction. Robust-variance random-effects meta-analysis revealed medium effect sizes at post-test (overall: g = 0...
May 20, 2018: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29781029/infrared-spectrum-and-intermolecular-potential-energy-surface-of-the-co-o-2-dimer
#10
A J Barclay, A R W McKellar, N Moazzen-Ahmadi, Richard Dawes, Xiao-Gang Wang, Tucker Carrington
Only a few weakly-bound complexes containing the O2 molecule have been characterized by high resolution spectroscopy, no doubt due to the complications added by the oxygen molecule's unpaired electron spin. Here we report an extensive infrared spectrum of CO-O2, observed in the CO fundamental band region using a tunable quantum cascade laser to probe a pulsed supersonic jet expansion. The rotational energy level pattern derived from the spectrum consists of stacks of levels characterized by the total angular momentum, J, and its projection on the intermolecular axis, K...
May 21, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29780342/long-term-efficacy-of-psychosocial-treatments-for-adults-with-attention-deficit-hyperactivity-disorder-a-meta-analytic-review
#11
Carlos López-Pinar, Sonia Martínez-Sanchís, Enrique Carbonell-Vayá, Javier Fenollar-Cortés, Julio Sánchez-Meca
Background: Recent evidence suggests that psychosocial treatments, particularly cognitive-behavioral therapy (CBT), are effective interventions for adult attention deficit hyperactivity disorder (ADHD). The objective of this review was to determine the long-term efficacy of psychosocial interventions in improving clinically relevant variables, including ADHD core symptoms, clinical global impression (CGI), and global functioning. Methods: In total, nine randomized controlled trials and three uncontrolled single-group pretest-posttest studies were included...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29780301/when-the-ostrich-algorithm-fails-blanking-method-affects-spike-train-statistics
#12
Kevin Joseph, Soheil Mottaghi, Olaf Christ, Thomas J Feuerstein, Ulrich G Hofmann
Modern electroceuticals are bound to employ the usage of electrical high frequency (130-180 Hz) stimulation carried out under closed loop control, most prominent in the case of movement disorders. However, particular challenges are faced when electrical recordings of neuronal tissue are carried out during high frequency electrical stimulation, both in-vivo and in-vitro . This stimulation produces undesired artifacts and can render the recorded signal only partially useful. The extent of these artifacts is often reduced by temporarily grounding the recording input during stimulation pulses...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29780111/life-threatening-hyperkalemia-associated-with-axitinib-treatment-in-patients-with-recurrent-renal-carcinoma-a-case-report
#13
Shigeo Godo, Yoshitaro Yoshida, Naoki Kawamorita, Koji Mitsuzuka, Yu Kawazoe, Motoo Fujita, Daisuke Kudo, Ryosuke Nomura, Hiroaki Shimokawa, Shigeki Kushimoto
Axitinib has emerged as a promising antineoplastic agent for the treatment of advanced renal cell carcinoma. Although the administration of axitinib was well-tolerated in clinical trials, the real-world safety and tolerability remain unverified. We herein report a patient with metastatic renal cell carcinoma who suddenly developed life-threatening hyperkalemia following the initiation of axitinib treatment. Although hyperkalemia has been reported with an incidence of <10%, acute severe hyperkalemia may be a considerably critical adverse event of axitinib therapy, especially in patients with risk factors for hyperkalemia...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29780093/-a-retrospective-analysis-of-chemotherapy-for-gastric-cancer-in-later-stage-elderly-patients
#14
Kenji Ina, Hiroko Ina, Masahiko Yoneda, Megumi Kabeya, Syuu Yuasa, Yuko Tomomatsu, Ryuichi Furuta
AIM: Despite the significant advances in chemotherapy, the prognosis of unresectable or recurrent gastric cancer is still very poor. Given that older adults are likely to have a number of concomitant diseases and an impaired major organ function, cancer chemotherapy in elderly patients requires particular caution. We examined what factors are associated with the overall survival of gastric cancer patients undergoing chemotherapy. METHODS: A retrospective chart review of gastric cancer patients receiving oral fluoropyrimidines (N=130) was performed at Nagoya Memorial Hospital over 9 years...
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29779782/the-association-of-neck-circumference-with-risk-of-metabolic-syndrome-and-its-components-in-adults-a-systematic-review-and-meta-analysis
#15
N Namazi, B Larijani, P J Surkan, L Azadbakht
BACKGROUND & AIMS: Several prior studies suggested that neck circumference (NC) is a reliable diagnostic tool for risk of metabolic syndrome (MetS) and its features. However, not all studies support this view. Therefore, we aimed to perform a meta-analysis to summarize the association between NC with MetS and its components in adult populations. METHODS AND RESULTS: PubMed/Medline, Web of Knowledge, and Scopus electronic databases were searched until May 31, 2017 to find relevant English-language papers...
March 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29779774/the-impact-of-repeated-nalc-naoh-decontamination-on-the-performance-of-xpert-mtb-rif-assay
#16
Andrea Rachow, Elmar Saathoff, Bariki Mtafya, Daniel Mapamba, Chacha Mangu, Gabriel Rojas-Ponce, Nyanda E Ntinginya, Martin Boeree, Norbert Heinrich, Stephen H Gillespie, Michael Hoelscher
The Xpert MTB/RIF assay detects Mycobacterium tuberculosis in unprocessed or NALC/NaOH- decontaminated sputum. The effect of repeated NALC/NaOH-decontamination on several Xpert performance parameters was assessed in this study. A second NALC/NaOH-decontamination had no effect on the binary Xpert-outcome but increased the value for the quantitative readout (CTmin ). Repeated decontamination was not associated with PCR-inhibition or invalid results. The CTmin of M.tb positive samples was higher in inhibited Xpert runs...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779297/cardiac-rhythm-management-devices
#17
Irene Stevenson, Alex Voskoboinik
BACKGROUND: The last decade has seen ongoing evolution and use of cardiac rhythm management devices, including pacemakers, cardiac resynchronisation therapy, implantable cardioverter defibrillators and loop recorders. General practitioners are increasingly involved in follow-up and management of patients with these devices. OBJECTIVE: The aim of this article is to provide an overview of different cardiac rhythm management devices, including their role, implant procedure, post-procedural care, potential complications and follow‑up...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29779190/therapeutic-strategies-for-modulating-the-extracellular-matrix-to-improve-pancreatic-islet-function-and-survival-after-transplantation
#18
REVIEW
Alexandra M Smink, Paul de Vos
PURPOSES OF REVIEW: Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve transplantation outcomes. This review discusses the current therapeutic strategies to modulate ECM components to improve islet engraftment. RECENT FINDINGS: Approaches applied are seeding islets in ECM of decellularized organs, supplementation of specific ECM components in polymeric scaffolds or immunoisolating capsules, and stimulating islet ECM production with specific growth factors or ECM-producing cells...
May 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29779059/youth-responses-to-school-shootings-a-review
#19
REVIEW
Áine Travers, Tracey McDonagh, Ask Elklit
PURPOSE OF REVIEW: This paper aims to synthesize research relating to youth responses to school shootings between 2014 and 2017. The main questions it addresses are how such events impact young people psychologically, and what risk or protective factors may contribute to different trajectories of recovery? RECENT FINDINGS: Recent research suggests that most young people exposed to school shootings demonstrate resilience, exhibiting no long-term dysfunction. However, a minority will experience severe and chronic symptoms...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29778724/a-tangle-of-forms-and-phylogeny-extensive-morphological-homoplasy-and-molecular-clock-heterogeneity-in-bonnetina-and-related-tarantulas
#20
David Ortiz, Oscar F Francke, Jason E Bond
Tarantula spider systematics has long been considered problematic. Species diagnosis and phylogenetic hypotheses have historically relied on morphological features, which are known to be relatively conserved and/or highly homoplastic across the family. Morphology-based attempts to clarify the phylogeny of the highly diverse New World Theraphosinae, have only been moderately successful, and the time-frame of tarantulas' evolution is nearly terra incognita. Here we present a molecular phylogenetic analysis of the Theraphosinae genus Bonnetina and related lineages, employing one mitochondrial (COI) and five nuclear (ITS1, EF1G, MID1IP1, MRPL44, and I3568) loci...
May 17, 2018: Molecular Phylogenetics and Evolution
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