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https://www.readbyqxmd.com/read/28528416/time-trends-of-persistent-organic-pollutants-in-benthic-and-pelagic-indicator-fishes-from-puget-sound-washington-usa
#1
James E West, Sandra M O'Neill, Gina M Ylitalo
We modeled temporal trends in polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and dichlorodiphenyltrichloroethane and its metabolites (DDTs) in two indicator fish species representing benthic and pelagic habitats in Puget Sound, Washington, USA. English sole (Parophrys vetulus, benthic) index sites and larger-scale Pacific herring (Clupea pallasii, pelagic) foraging areas represented a wide range of possible contamination conditions, with sampling locations situated adjacent to watersheds exhibiting high, medium and low development...
May 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28528407/effects-of-feeding-strategy-sediment-characteristics-and-chemical-properties-on-polychlorinated-biphenyl-and-polybrominated-diphenyl-ether-bioaccumulation-from-marine-sediments-in-two-invertebrates
#2
H Frouin, P Jackman, N D Dangerfield, P S Ross
Shellfish and sediment invertebrates have been widely used to assess pollution trends over space and time in coastal environments around the world. However, few studies have compared the bioaccumulation potential of different test species over a range of sediment-contaminant concentrations and profiles. The bioavailability of sediment-related contaminants was evaluated using sediments collected from sites (n = 12) throughout the Salish Sea, British Columbia, Canada. Two benthic marine invertebrates-the Baltic clam Macoma balthica and the polychaete worm Neanthes arenaceodentata-were exposed for 28 days in a controlled environment to these field-collected coastal sediments...
May 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28528147/variability-and-reproducibility-of-segmental%C3%A2-longitudinal-strain-measurement-a-report-from-the-eacvi-ase-strain-standardization-task%C3%A2-force
#3
Oana Mirea, Efstathios D Pagourelias, Jurgen Duchenne, Jan Bogaert, James D Thomas, Luigi P Badano, Jens-Uwe Voigt
OBJECTIVES: In this study, we compared left ventricular (LV) segmental strain measurements obtained with different ultrasound machines and post-processing software packages. BACKGROUND: Global longitudinal strain (GLS) has proven to be a reproducible and valuable tool in clinical practice. Data about the reproducibility and intervendor differences of segmental strain measurements, however, are missing. METHODS: We included 63 volunteers with cardiac magnetic resonance-proven infarct scar with segmental LV function ranging from normal to severely impaired...
May 12, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28527320/the-impact-of-extracurricular-activities-participation-on-youth-delinquent-behaviors-an-instrumental-variables-approach
#4
Sehee Han, Joongyeup Lee, Kyung-Gook Park
The purpose of this study was to examine the association between extracurricular activities (EA) participation and youth delinquency while tackling an endogeneity problem of EA participation. Using survey data of 12th graders in South Korea (n = 1943), this study employed an instrumental variables approach to address the self-selection problem of EA participation as the data for this study was based on an observational study design. We found a positive association between EA participation and youth delinquency based on conventional regression analysis...
May 17, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28527055/cluster-headache-present-and-future-therapy
#5
Massimo Leone, Alessandro Giustiniani, Alberto Proietti Cecchini
Cluster headache is characterized by severe, unilateral headache attacks of orbital, supraorbital or temporal pain lasting 15-180 min accompanied by ipsilateral lacrimation, rhinorrhea and other cranial autonomic manifestations. Cluster headache attacks need fast-acting abortive agents because the pain peaks very quickly; sumatriptan injection is the gold standard acute treatment. First-line preventative drugs include verapamil and carbolithium. Other drugs demonstrated effective in open trials include topiramate, valproic acid, gabapentin and others...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28526336/activation-of-na-h-exchanger-other-than-formation-of-transmembrane-pore-underlies-the-cytotoxicity-of-nematocyst-venom-from-chrysaora-helvola-brandt-jellyfish
#6
Lanlan Fan, Jun Luo, Xiaoyong Li, Ming Chen, Wei Shu, Xiaosheng Qu
We previously reported unexpected apoptosis-like cell death induced by nematocyst venom (NV) from Chrysaora helvola Brandt (C. helvola) jellyfish. To assess whether the pore formation mechanism underlay the action of NV, the change in cell membrane permeability was studied in both chicken erythrocytes and human CNE-2 cells. Initially, paradoxical results were derived from osmoprotectant protection assays. Polyethylene glycol (PEG)2000, which completely inhibited the NV induced hemolysis, failed to protect CNE-2 cells...
May 16, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28525620/cold-hardiness-of-the-black-soldier-fly-diptera-stratiomyidae
#7
Thomas Spranghers, Annelies Noyez, Kristof Schildermans, Patrick De Clercq
The black soldier fly, Hermetia illucens (L.), shows potential as a resource for animal feed. However, industrial production in regions where the insect is not native, like northwestern Europe, could lead to permanent establishment, which might entail environmental risks. In temperate climates, establishment depends on the insect's ability to overwinter. This study assessed the insect's cold hardiness by determining the supercooling point (SCP) and lower lethal time at 5 °C (LTime10,50,90) for different life stages...
May 19, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28525532/the-effects-of-indirect-and-direct-acting-anticoagulants-on-lupus-anticoagulant-assays-a-large-retrospective-study-at-a-coagulation-reference-laboratory
#8
Jansen N Seheult, Michael P Meyer, Franklin A Bontempo, Irina Chibisov
Objectives: To investigate the effects of indirect- and direct-acting anticoagulants on the interpretation of lupus anticoagulant (LAC) assays. Methods: A retrospective database review was performed to identify all LAC panels from November 2012 to November 2015. The positivity rates for three LAC tests were compared among various anticoagulant medications. Results: This analysis included 7,721 LAC panels. Direct oral anticoagulants, warfarin, and unfractionated heparin (UFH) were associated with higher LAC positivity rates compared with patients not receiving documented anticoagulation (83% for argatroban, 58% for dabigatran, 72% for rivaroxaban, 53% for apixaban, 56% for warfarin, and 36% for UFH vs 29% for no anticoagulation, P < ...
May 19, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28525344/morphometric-abnormalities-in-spleen-and-kidney-of-the-progeny-of-mice-fed-american-cranberry-extract-vaccinium-macrocarpon-during-pregnancy-and-lactation
#9
B J Bałan, S Lewicki, A K Siwicki, M Stelmasiak, P Skopiński, E Skopińska-Różewska, A Wasiutyński, R Zdanowski
Cranberries and cranberry-derived diet supplements are often recommended for the treatment of urinary tract infections, also during pregnancy. These products contain strongly anti-angiogenic chemical compounds which could not be indifferent to the developing fetus. In the present work we evaluated the effect of feeding pregnant and lactating mice American cranberry extract (daily dose 0.88 mg) on the morphology and some parameters of spleen and kidney function of their adult progeny. Six weeks after delivery the morphometry of spleen and kidney, cytometric analysis of spleen lymphocytes, evaluation of humoral response to SRBC (Sheep Red Blood Cells), and examination of serum creatinine/urea concentration, were performed in the offspring...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28524831/a-case-series-of-liver-abscess-formation-after-transcatheter-arterial-chemoembolization-for-hepatic-tumors
#10
Wei Sun, Fei Xu, Xiao Li, Chen-Rui Li
BACKGROUND: Liver abscess is a serious complication following transcatheter arterial chemoembolization (TACE). Much attention has been paid to this condition as it may interfere with the treatment process and result in a poor prognosis of the patient. This study aimed to analyze the causes of liver abscess, a complication, after TACE for hepatic tumors and to summarize management approaches. METHODS: From June 2012 to June 2014, of 1480 consecutive patients who underwent TACE at our hospital, five patients developed liver abscess after TACE procedures for hepatic tumors...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28524003/targeting-the-programmed-cell-death-1-pathway-in-genitourinary-tumors-current-progress-and-future-perspectives
#11
Rodolfo Montironi, Liang Cheng, Holger Moch, Antonio Lopez-Beltran, Marina Scarpelli, Francesco Massari, Michelangelo Fiorentino, Chiara Ciccarese, Michael Koch, Hristos Z Kaimakliotis, Lisha Wang, Roberto Pili, Steven A Mann
Immune checkpoint inhibitors have revolutionized the treatment many malignancies with over a dozen new United States Food and Drug Administration (FDA) approvals in the past six years. Due to the combination of potent treatment success and potentially deadly adverse effects from immune checkpoint inhibitors, gathering prognostic and predictive information about FDA-indicated tumors is prudent. PD-L1 expression is a poor prognostic factor and predictive of better responses from both PD-1 and PD-L1 inhibitors in a variety of tumor types including RCC and urothelial carcinoma...
May 18, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28523520/hepatitis-e-virus-serology-and-pcr-does-the-methodology-matter
#12
Lien Cattoir, Frederik Van Hoecke, Tom Van Maerken, Eveline Nys, Inge Ryckaert, Matthias De Boulle, Anja Geerts, Xavier Verhelst, Isabelle Colle, Veronik Hutse, Vanessa Suin, Magali Wautier, Steven Van Gucht, Hans Van Vlierberghe, Elizaveta Padalko
Hepatitis E virus (HEV) genotype 3 is an emerging pathogen in the developed world. As the clinical manifestations and routine laboratory parameters are often nonspecific, accurate diagnostic tests are crucial. In the current study, the performance of six serological assays and three PCR assays for the detection of HEV was evaluated. In the setting of the Ghent University Hospital, patients with clinically suspected HEV infection were tested for the presence of HEV IgM and IgG as well as HEV RNA. Serology was performed using six commercial HEV ELISA assays: Biorex, Wantai and Mikrogen IgM and IgG...
May 18, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28523472/assessment-of-coronary-artery-by-prospective-ecg-triggered-256-multi-slice-ct-on-children-with-congenital-heart-disease
#13
Li-Ping Yao, Li Zhang, Hui-Ming Li, Ming Ding, Ling-Wei Yu, Xin Yang, Xiao-Ming Li, Kun Sun
This study aims to investigate the imaging quality and radiation dose of prospective ECG-triggered 256 multi-slice computer tomography (MSCT) in accessing the coronary artery (CA) in children. Coronary arteries of 149 children were evaluated using prospective ECG-triggered 256 MSCT with the same system settings. A four-point scoring system was applied to study the capability of MSCT in detecting CA in these patients. Signal, noise and contrast-to-noise ratios (CNR) were analyzed to investigate the association of image quality with age...
May 18, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28523138/tips-and-tricks-of-the-propensity-score-methods-in-the-thoracic-surgery-research
#14
EDITORIAL
Luca Bertolaccini, Alessandro Pardolesi, Piergiorgio Solli
Without randomization, the differences in the distribution of baseline covariates can confound the evaluation of outcomes between the groups. To estimate the causal effects of treatment on the results randomized clinical trials (RCT) are routinely used. When RCT are not feasible for cost, time, and ethical issues, the effect of treatment on an inevitable outcome could be investigated by using a non-experimental study design. The propensity score (PS) refers to the individual probability, for a subject involved in a study, of receiving a new treatment rather than the control treatment...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28521951/validation-of-the-anybody-full-body-musculoskeletal-model-in-computing-lumbar-spine-loads-at-l4l5-level
#15
Tito Bassani, Elena Stucovitz, Zhihui Qian, Matteo Briguglio, Fabio Galbusera
In the panorama of available musculoskeletal modeling software, AnyBody software is a commercial tool that provides a full body musculoskeletal model which is increasingly exploited by numerous researchers worldwide. In this regard, model validation becomes essential to guarantee the suitability of the model in representing the simulated system. When focusing on lumbar spine, the previous works aimed at validating the AnyBody model in computing the intervertebral loads held several limitations, and a comprehensive validation is to be considered as lacking...
May 5, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28521771/cancer-incidence-among-finnish-male-cobalt-production-workers-in-1969-2013-a-cohort-study
#16
Riitta Sauni, Panu Oksa, Jukka Uitti, Asko Linna, Raimo Kerttula, Eero Pukkala
BACKGROUND: There is inadequate evidence for the carcinogenicity of cobalt and cobalt compounds in humans. Consequently, the International Agency for Research on Cancer (IARC) has evaluated cobalt metal without tungsten carbide as possibly carcinogenic to humans (Group 2B). The aim of the study was to assess the risk of cancer among workers employed in a Finnish cobalt plant since the beginning of production in 1968. METHODS: The study cohort consisted of all males employed by the Finnish cobalt plant for at least a year during 1968-2004...
May 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28521683/impact-of-red-wine-consumption-on-cardiovascular-health
#17
Luca Liberale, Aldo Bonaventura, Fabrizio Montecucco, Franco Dallegri, Federico Carbone
The devastating effects of heavy alcohol drinking have been long time recognized. In the last decades, potential benefits of modest red wine drinking were suggested. In European countries in which red wide intake is not negligible (such as France), the association between cholesterol and cardiovascular (CV) risk was less evident, suggesting the action of some protective molecules in red wine or other foods and drinks. Epidemiological and mechanistic evidence of a J-shaped relationship between red wine intake and CV risk further supported the "French paradox"...
May 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28521565/interleukin-17-inhibition-role-in-psoriasis-and-inflammatory-bowel-disease
#18
Megan Hohenberger, Leah A Cardwell, Elias Oussedik, Steven R Feldman
INTRODUCTION: Interleukin 17 (IL-17) antagonism provides a highly effective approach for treating psoriasis. Exacerbations of inflammatory bowel disease have been reported in anti-IL-17 psoriasis trials. AIM: To characterize the relationship between IL-17 inhibition and inflammatory bowel disease. METHODS: A review of English-language articles was performed. Search terms included IL-17, psoriasis, inflammatory bowel disease, secukinumab, ixekizumab, and brodalumab...
May 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28520850/anatomical-study-of-temporal-fat-compartments-and-its-clinical-application-for-temporal-fat-grafting
#19
Ru-Lin Huang, Yun Xie, Wenjin Wang, Tanja Herrler, Jia Zhou, Peijuan Zhao, Lee L Q Pu, Qingfeng Li
Background: Low satisfaction rates and severe complications are two major limitations for temporal hollowing augmentation using autologous fat grafting. Despite fat compartments in temporal region have been reported, its clinical applied anatomy for fat grafting have not been the subject of studies that show its benefits objectively and statistically. Objectives: To investigate temporal fat compartments and relative neurovascular structures in cadavers, developing a safe and effective fat grafting technique for temporal hollowing augmentation...
May 18, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28520725/reading-positional-codes-with-fmri-problems-and-solutions
#20
Kristjan Kalm, Dennis Norris
Neural mechanisms which bind items into sequences have been investigated in a large body of research in animal neurophysiology and human neuroimaging. However, a major problem in interpreting this data arises from a fact that several unrelated processes, such as memory load, sensory adaptation, and reward expectation, also change in a consistent manner as the sequence unfolds. In this paper we use computational simulations and data from two fMRI experiments to show that a host of unrelated neural processes can masquerade as sequence representations...
2017: PloS One
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