Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Hanbing Li, Lingling Gao, Xiao Yang, Lu Chen
OBJECTIVES: This study aims to develop and validate a prediction model for preterm birth in women with gestational diabetes mellitus (GDM). DESIGN: We conducted a retrospective study on women with GDM who gave birth at the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, between November 2017 and July 2021. We divided 1879 patients into a development set (n = 1346) and a validation set (n = 533). The development set was used to construct the prediction model for preterm birth using the stepwise logistic regression model...
March 11, 2024: Clinical Endocrinology
#22
JOURNAL ARTICLE
Zhangmin Tan, Peizhen Zhang, Jin Zhou, Chuo Li, Chengfang Xu, Yuzhu Yin
BACKGROUND: Although pregnancy complicated by liver cirrhosis is rare, women with cirrhosis experience increased adverse pregnancy outcomes. This study aimed to evaluate pregnancy outcomes in women with liver cirrhosis and develop a predictive model using maternal factors for preterm birth in such pregnancies. METHODS: A retrospective analysis was conducted on pregnancy outcomes of a cirrhosis group (n = 43) and a non-cirrhosis group (n = 172) in a university hospital between 2010 and 2022...
March 7, 2024: BMC Pregnancy and Childbirth
#23
JOURNAL ARTICLE
Minna K Karjalainen, Savita Karthikeyan, Clare Oliver-Williams, Eeva Sliz, Elias Allara, Wing Tung Fung, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko Salomaa, Matt Goodwin, David A Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, Anubha Mahajan, Matt J Neville, Natalie R van Zuydam, Renée de Mutsert, Ruifang Li-Gao, Dennis O Mook-Kanamori, Ayse Demirkan, Jun Liu, Raymond Noordam, Stella Trompet, Zhengming Chen, Christiana Kartsonaki, Liming Li, Kuang Lin, Fiona A Hagenbeek, Jouke Jan Hottenga, René Pool, M Arfan Ikram, Joyce van Meurs, Toomas Haller, Yuri Milaneschi, Mika Kähönen, Pashupati P Mishra, Peter K Joshi, Erin Macdonald-Dunlop, Massimo Mangino, Jonas Zierer, Ilhan E Acar, Carel B Hoyng, Yara T E Lechanteur, Lude Franke, Alexander Kurilshikov, Alexandra Zhernakova, Marian Beekman, Erik B van den Akker, Ivana Kolcic, Ozren Polasek, Igor Rudan, Christian Gieger, Melanie Waldenberger, Folkert W Asselbergs, Caroline Hayward, Jingyuan Fu, Anneke I den Hollander, Cristina Menni, Tim D Spector, James F Wilson, Terho Lehtimäki, Olli T Raitakari, Brenda W J H Penninx, Tonu Esko, Robin G Walters, J Wouter Jukema, Naveed Sattar, Mohsen Ghanbari, Ko Willems van Dijk, Fredrik Karpe, Mark I McCarthy, Markku Laakso, Marjo-Riitta Järvelin, Nicholas J Timpson, Markus Perola, Jaspal S Kooner, John C Chambers, Cornelia van Duijn, P Eline Slagboom, Dorret I Boomsma, John Danesh, Mika Ala-Korpela, Adam S Butterworth, Johannes Kettunen
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1-7 . This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8-11 . Here we present a genome-wide association study for 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up to 136,016 participants from 33 cohorts...
March 6, 2024: Nature
#24
JOURNAL ARTICLE
Hakan Golbasi, Burak Bayraktar, Ceren Golbasi, Ibrahim Omeroglu, Duygu Adiyaman, Kaan Okan Alkan, Taha Resid Ozdemir, Ozge Kaya Ozer, Berk Ozyilmaz, Atalay Ekin
PURPOSE: To determine the association between fetal fraction (FF) levels in cell-free fetal DNA (cffDNA) testing and adverse pregnancy outcomes. METHODS: This retrospective cohort study, conducted at a single center, involved 2063 pregnant women with normal 1st and 2nd trimester non-invasive prenatal test (NIPT) results between 2016 and 2021. Pregnancy outcomes were examined by determining the < 4% and < 5th percentile (3.6%) cut-off values for low fetal fraction (LFF)...
March 5, 2024: Archives of Gynecology and Obstetrics
#25
JOURNAL ARTICLE
Yonghui Yang, Xiaori He, Xuefei Zhang, Pingyang Chen
OBJECTIVES: With the development of perinatal and neonatal intensive care medicine, the survival rate of very premature infants increases year by year. However, the incidence of bronchopulmonary dysplasia (BPD) increases year by year, which seriously affects the survival prognosis of very premature infants. How to prevent and treat BPD effectively has become the focus of neonatologists. This study aims to provide ideas for the prevention and treatment of BPD in very preterm infants via analyzing the clinical characteristics of BPD...
October 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
#26
JOURNAL ARTICLE
Xia Li, Qin-Yu Cai, Xin Luo, Yong-Heng Wang, Li-Zhen Shao, Shu-Juan Luo, Lan Wang, Ying-Xiong Wang, Xia Lan, Tai-Hang Liu
PURPOSE: To evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) with gestational diabetes mellitus (GDM) on perinatal outcomes and establish a prediction model of adverse perinatal outcomes in women with ICP. METHODS: This multicenter retrospective cohort study included the clinical data of 2,178 pregnant women with ICP, including 1,788 women with ICP and 390 co-occurrence ICP and GDM. The data of all subjects were collected from hospital electronic medical records...
March 1, 2024: Diabetology & Metabolic Syndrome
#27
JOURNAL ARTICLE
Minhazur Sarker, Chelsea Ann DeBolt, Dana Canfield, Lauren Ferrara
Intrahepatic cholestasis of pregnancy is associated with adverse pregnancy outcomes including intrauterine fetal demise, spontaneous preterm labor, and meconium-stained amniotic fluid. Studies have yet to determine if patients with a history of pregnancy complicated by cholestasis had an association with more adverse outcomes in a subsequent pregnancy complicated by cholestasis. Study Design. Retrospective cohort study of multiparous, singleton, non-anomalous live gestations complicated by cholestasis at Elmhurst Hospital Center from 2005-2019...
February 29, 2024: American Journal of Perinatology
#28
JOURNAL ARTICLE
Shuliang Zhao, Huimin Jiang, Yiqun Miao, Wenwen Liu, Yanan Li, Hui Liu, Aihua Wang, Xinghui Cui, Yuanyuan Zhang
BACKGROUND: Necrotizing enterocolitis (NEC) is a multifactorial gastrointestinal disease with high morbidity and mortality among premature infants. However, studies with large samples on the factors of NEC in China have not been reported. This meta-analysis aims to systematically review the literature to explore the influencing factors of necrotizing enterocolitis in premature infants in China and provide a reference for the prevention of NEC. METHODS: PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), Wanfang and VIP databases were systematically searched from inception to February 2023...
February 29, 2024: BMC Pediatrics
#29
REVIEW
Giorgia Porrello, Roberto Cannella, Jacques Bernuau, Antoine Agman, Giuseppe Brancatelli, Marco Dioguardi Burgio, Valérie Vilgrain
Liver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve the maternal liver and guarantee materno-fetal survival. While detailed questioning of the patient and a clinical examination are highly important, imaging is often essential to reach a diagnosis of these liver diseases and lesions. Three groups of liver diseases may be observed during pregnancy: (1) diseases related to pregnancy: intrahepatic cholestasis of pregnancy, pre-eclampsia, eclampsia, hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, and acute fatty liver of pregnancy; (2) liver diseases that are more frequent during or exacerbated by pregnancy: acute herpes simplex hepatitis, Budd-Chiari syndrome, hemorrhagic hereditary telangiectasia, hepatocellular adenoma, portal vein thrombosis, and cholelithiasis; (3) coincidental conditions, including acute hepatitis, incidental focal liver lesions, metabolic dysfunction-associated steatotic liver disease, cirrhosis, hepatocellular carcinoma, liver abscesses and parasitosis, and liver transplantation...
February 27, 2024: Insights Into Imaging
#30
JOURNAL ARTICLE
Amir Hamud, Matan J Cohen, Drorith Hochner-Celnikier, Benjamin Bar-Oz, Zvi Ackerman
INTRODUCTION AND OBJECTIVES: Intrahepatic cholestasis of pregnancy (ICP) is often accompanied by fetal and maternal complications. MATERIALS AND METHODS: Retrospective review of the clinical course of women with ICP and their neonates treated at our medical center over a 10-year period. Special attention was paid to the maternal and neonatal response to 2 different modes of ursodeoxycholic acid (UDCA) administration. RESULTS: Neonates of mothers with high total bile acid levels had a poorer composite neonatal outcome...
February 23, 2024: Annals of Hepatology
#31
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 25, 2024: Zhonghua Fu Chan Ke za Zhi
#32
JOURNAL ARTICLE
Li-Wen Liu, Yan Chen, Liu-Jing Zhu, Qun-Xiang Xu, Shaolin Xu, Yanling Ding, Biao Yin
OBJECTIVE: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with a high incidence of complications in the mid and late stages of gestation. This study investigates differences in the composition of intestinal flora among pregnant women diagnosed with ICP, employing Illumina MiSeq high-throughput sequencing technology. METHODS: This case-control study obtained patient data from the hospital information system (HIS) and the laboratory information system (LIS)...
February 29, 2024: Heliyon
#33
REVIEW
Rebecca Roediger, Jaquelyn Fleckenstein
No abstract text is available yet for this article.
2024: Clinical Liver Disease
#34
JOURNAL ARTICLE
Dan Shan, Qian Chen, Yupei Xie, Siyu Dai, Yayi Hu
Trace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma...
February 17, 2024: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
#35
JOURNAL ARTICLE
Ralley Prentice, Emma Flanagan, Emily Wright, Lani Prideaux, William Connell, Miles Sparrow, Peter De Cruz, Mark Lust, Winita Hardikar, Rimma Goldberg, Sara Vogrin, Kirsten Palmer, Alyson Ross, Megan Burns, Tessa Greeve, Sally Bell
BACKGROUND AND AIMS: The risk of intrahepatic cholestasis of pregnancy (ICP) is increased in thiopurine exposed pregnancies. Thiopurine 'shunting', with a 6-methylmecrcaptopurine (MMP) to 6-thioguanine (TGN) ratio of >11, progresses over pregnancy, and may promote ICP development. We aimed to explore the association between thiopurine exposure and ICP, including the hypothesized impact of thiopurine shunting, and identify risk minimization strategies. METHODS: This prospective multi-centre cohort study compared thiopurine and biologic monotherapy exposed pregnant participants...
February 15, 2024: Journal of Crohn's & Colitis
#36
JOURNAL ARTICLE
Alireza Sadeghi
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) typically develops in the late second and third trimesters and resolves rapidly after delivery. Although not associated with serious maternal sequelae, ICP can be highly bothersome. On the other hand, the major complications of ICP are fetal and neonatal, which can be fatal. The current knowledge lacks an estimation regarding the global prevalence of ICP. METHODS: PubMed, Scopus, and Web of Science will be searched systematically...
February 2024: Health Science Reports
#37
JOURNAL ARTICLE
Ningzhen Ye, Xinrui Shi, Jianyi Gao, Ruirui Dong, Gaoying Wang, Jing Wang, Liang Luo, Ting Zhang
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is associated with adverse pregnancy outcomes; however, the underlying mechanisms are not fully understood. AIMS: This study aimed to determine the role of exosomal miR-6891-5p in placental trophoblast dysfunction in ICP and identify new biomarkers for ICP diagnosis. METHODS: Serum samples were collected from ICP patients and healthy pregnant women, and serum exosomes were extracted and identified...
February 15, 2024: Digestive Diseases and Sciences
#38
JOURNAL ARTICLE
Razan Saadi, Alla Saban, Adi Y Weintraub, David Yardeni, Tamar Eshkoli
OBJECTIVE: To assess the association between aspartate aminotransferase (AST) to platelet count ratio index (APRI score), during the first and third trimesters of pregnancy and the development of intrahepatic cholestasis in pregnancy (ICP). METHODS: Case-control study was conducted. The study included patients diagnosed with ICP by elevated bile acids (n = 118) and a control group of women with symptoms such as elevated liver enzymes or pruritus with normal level of bile acids (n = 127) who attended a large tertiary teaching medical center between the years 2014 and 2021...
February 15, 2024: Archives of Gynecology and Obstetrics
#39
JOURNAL ARTICLE
Gaoying Wang, Ruirui Dong, Haijian Zhao, Ningzhen Ye, Jing Wang, Jing Cheng, Xinrui Shi, Liang Luo, Ting Zhang
BACKGROUND: Abnormal bile acid metabolism leading to changes in placental function during pregnancy. To determine whether endoplasmic reticulum protein 29 (ERp29) can mediate the pregnancy effects of cholestasis by altering the level of trophoblast cell apoptosis. METHODS: ERp29 in serum of 66 intrahepatic cholestasis of pregnancy (ICP) pregnant women and 74 healthy were detected by ELISA. Subcutaneous injection of ethinyl estradiol (E2) was used to induce ICP in pregnant rats...
February 8, 2024: Placenta
#40
JOURNAL ARTICLE
Zehra Vural Yılmaz, Oğuz Özdemir, Gözde Yasemin Kurt, Çağanay Soysal, Elif Yılmaz
OBJECTIVES: We aimed to evaluate feto-maternal blood flow parameters using Doppler ultrasonography (USG) in pregnant women with intrahepatic cholestasis of pregnancy (ICP) and the effect of ursodeoxycholic acid (UDCA) treatment on these parameters. MATERIAL AND METHODS: This prospective cohort study was performed at Dr. Sami Ulus Women's and Children's Health Teaching and Research Hospital, in Turkey between September 2022 and February 2023. Sixty pregnant women, 30 with ICP disease and 30 healthy women were included in the study...
February 9, 2024: Ginekologia Polska
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
