keyword
https://read.qxmd.com/read/38528518/mendelian-randomization-analysis-reveals-causal-relationship-between-obstetric-related-diseases-and-covid-19
#1
JOURNAL ARTICLE
Yan Fang, Dajun Fang
BACKGROUND: Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes. METHODS: A two-sample Mendelian randomization (MR) analysis in this study was used to evaluate the casual relationships between COVID-19 infection and obstetric-related diseases based on genome-wide association studies (GWAS) dataset...
March 25, 2024: Virology Journal
https://read.qxmd.com/read/38515230/the-correlation-between-serum-total-bile-acid-and-adverse-perinatal-outcomes-in-pregnant-women-with-intrahepatic-cholestasis-of-pregnancy-icp-and-non-icp-hypercholanemia-of-pregnancy
#2
JOURNAL ARTICLE
Peizhen Zhang, Zhangmin Tan, Chuo Li, Zhenyan Han, Jin Zhou, Yuzhu Yin
BACKGROUND: The association between excessive serum total bile acid (TBA) and adverse perinatal outcomes in individuals with non-intrahepatic cholestasis of pregnancy (non-ICP) hypercholanemia has not been determined, and it is unclear if this link is similar to that observed in patients with ICP. OBJECTIVE: To examine the adverse perinatal outcomes in two specific subcategories: those with ICP and those with non-ICP, including individuals with liver disease and asymptomatic hypercholanemia of pregnancy (AHP), at different levels of TBA...
December 2024: Annals of Medicine
https://read.qxmd.com/read/38513931/metabolomic-profiling-of-serum-and-tongue-coating-of-pregnant-women-with-intrahepatic-cholestasis-in-pregnancy
#3
JOURNAL ARTICLE
Feng Zhang, Fang Liu, Xiaoyi Xu, Weilan Su, Yu Rong, Fu-Ying Tian, Weimin Xiao, Yichun Wu, Kai P Law, Ping Wen
Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of cesarean section and adverse fetal outcomes. Currently, ICP diagnosis depends largely on serum levels of bile acids and lacks sensitivity and specificity for accurate diagnosis. Tongue diagnosis is an important diagnostic tool in traditional Chinese medicine (TCM) and is used in our clinic as complementary treatment and personalized medicine for ICP. However, the molecular basis of the manifestation of greasy white tongue coatings in ICP remains unknown...
March 19, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38510082/hyperglycemia-in-pregnancy-did-not-worsen-the-short-term-outcomes-of-very-preterm-infants-a-propensity-score-matching-study
#4
JOURNAL ARTICLE
Ying Li, Wei Shen, Rong Zhang, Jian Mao, Ling Liu, Yan-Mei Chang, Xiu-Zhen Ye, Yin-Ping Qiu, Li Ma, Rui Cheng, Hui Wu, Dong-Mei Chen, Ling Chen, Ping Xu, Hua Mei, San-Nan Wang, Fa-Lin Xu, Rong Ju, Xiao-Mei Tong, Xin-Zhu Lin, Fan Wu
BACKGROUND: Hyperglycemia in pregnancy (HGP) has generally been considered a risk factor associated with adverse outcomes in offspring, but its impact on the short-term outcomes of very preterm infants remains unclear. METHODS: A secondary analysis was performed based on clinical data collected prospectively from 28 hospitals in seven regions of China from September 2019 to December 2020. According to maternal HGP, all infants were divided into the HGP group or the non-HGP group...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38500903/comparing-transvaginal-ultrasound-measurements-of-cervical-length-to-bishop-score-in-predicting-cesarean-section-following-induction-of-labor-a-prospective-observational-study
#5
JOURNAL ARTICLE
Parul Sinha, Mansi Gupta, Snehlata Meena
INTRODUCTION:  Bishop score (BS) has been used to see the favorability of the cervix for induction of labor (IOL), but it has limitations in today's diverse patient population. We aimed to assess the predictive value of transvaginal ultrasound (TVUS) measurements of cervical length (CL) compared to BS in determining the likelihood of cesarean section (CS) following IOL. METHODOLOGY: A prospective observational study was conducted on 120 women requiring IOL in a tertiary care hospital in central India...
February 2024: Curēus
https://read.qxmd.com/read/38469760/role-of-systemic-immune-inflammatory-index-to-predict-intrahepatic-cholestasis-of-pregnancy
#6
JOURNAL ARTICLE
Seval Y Ergani, Sevki Celen
BACKGROUND: The goal was to investigate the change of systemic immune inflammation index (SII) in high-risk pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP). METHODS: Between May 2018 and April 2020, we retrospectively enrolled 218 pregnant women who were followed in our hospital from the first trimester to delivery. We looked at the sociodemographics, laboratory data, SII values, Apgar ratings, and newborn birth weights of pregnant women with ICP...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38465703/third-trimester-fetal-pancreas-imaging-in-uncomplicated-pregnancies-and-association-with-pregnancy-outcomes
#7
JOURNAL ARTICLE
Hakan Golbasi, Burak Bayraktar, Ceren Golbasi, Ibrahim Omeroglu, Bahar Konuralp Atakul, Zubeyde Emiralioglu Cakir, Ilknur Gumus Toka, Atalay Ekin
OBJECTIVE: To examine third-trimester sonographic imaging of the fetal pancreas in uncomplicated pregnancies and its association with pregnancy outcomes. METHODS: This was a prospective cohort study including 274 pregnant women. Uncomplicated pregnancies in the third trimester (28-40 weeks) were included in the study. Maternal chronic disease, pregnancy-related disorders such as hypertension, diabetes, cholestasis, smoking, and fetal abnormalities were determined as exclusion criteria...
March 11, 2024: Journal of Clinical Ultrasound: JCU
https://read.qxmd.com/read/38465073/key-components-of-successful-management-of-acute-fatty-liver-of-pregnancy-a-case-report-and-literature-review
#8
Rekha Patidar, Krishi Gowdra Revannasiddappa, Muniza Ghazanfer
Acute fatty liver of pregnancy (AFLP) is a rare, potentially fatal obstetric emergency. Due to its nonspecific signs and symptoms, there is often a delay in diagnosis and management which is associated with morbid complications and high mortality. We report a case of a 30-year-old female gravida 3 para 2 at 32 weeks gestation who presented with nausea and vomiting for two weeks, pruritis for three days, and upper abdomen pain for a day. A clinical diagnosis of HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome/obstetric cholestasis/AFLP was made...
February 2024: Curēus
https://read.qxmd.com/read/38462989/development-and-validation-of-a-risk-prediction-model-for-preterm-birth-in-women-with-gestational-diabetes-mellitus
#9
JOURNAL ARTICLE
Hanbing Li, Lingling Gao, Xiao Yang, Lu Chen
OBJECTIVES: This study aims to develop and validate a prediction model for preterm birth in women with gestational diabetes mellitus (GDM). DESIGN: We conducted a retrospective study on women with GDM who gave birth at the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, between November 2017 and July 2021. We divided 1879 patients into a development set (n = 1346) and a validation set (n = 533). The development set was used to construct the prediction model for preterm birth using the stepwise logistic regression model...
March 11, 2024: Clinical Endocrinology
https://read.qxmd.com/read/38454374/outcomes-of-pregnancies-complicated-by-cirrhosis-a-retrospective-cohort-study
#10
JOURNAL ARTICLE
Zhangmin Tan, Peizhen Zhang, Jin Zhou, Chuo Li, Chengfang Xu, Yuzhu Yin
BACKGROUND: Although pregnancy complicated by liver cirrhosis is rare, women with cirrhosis experience increased adverse pregnancy outcomes. This study aimed to evaluate pregnancy outcomes in women with liver cirrhosis and develop a predictive model using maternal factors for preterm birth in such pregnancies. METHODS: A retrospective analysis was conducted on pregnancy outcomes of a cirrhosis group (n = 43) and a non-cirrhosis group (n = 172) in a university hospital between 2010 and 2022...
March 7, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38448586/genome-wide-characterization-of-circulating-metabolic-biomarkers
#11
JOURNAL ARTICLE
Minna K Karjalainen, Savita Karthikeyan, Clare Oliver-Williams, Eeva Sliz, Elias Allara, Wing Tung Fung, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko Salomaa, Matt Goodwin, David A Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, Anubha Mahajan, Matt J Neville, Natalie R van Zuydam, Renée de Mutsert, Ruifang Li-Gao, Dennis O Mook-Kanamori, Ayse Demirkan, Jun Liu, Raymond Noordam, Stella Trompet, Zhengming Chen, Christiana Kartsonaki, Liming Li, Kuang Lin, Fiona A Hagenbeek, Jouke Jan Hottenga, René Pool, M Arfan Ikram, Joyce van Meurs, Toomas Haller, Yuri Milaneschi, Mika Kähönen, Pashupati P Mishra, Peter K Joshi, Erin Macdonald-Dunlop, Massimo Mangino, Jonas Zierer, Ilhan E Acar, Carel B Hoyng, Yara T E Lechanteur, Lude Franke, Alexander Kurilshikov, Alexandra Zhernakova, Marian Beekman, Erik B van den Akker, Ivana Kolcic, Ozren Polasek, Igor Rudan, Christian Gieger, Melanie Waldenberger, Folkert W Asselbergs, Caroline Hayward, Jingyuan Fu, Anneke I den Hollander, Cristina Menni, Tim D Spector, James F Wilson, Terho Lehtimäki, Olli T Raitakari, Brenda W J H Penninx, Tonu Esko, Robin G Walters, J Wouter Jukema, Naveed Sattar, Mohsen Ghanbari, Ko Willems van Dijk, Fredrik Karpe, Mark I McCarthy, Markku Laakso, Marjo-Riitta Järvelin, Nicholas J Timpson, Markus Perola, Jaspal S Kooner, John C Chambers, Cornelia van Duijn, P Eline Slagboom, Dorret I Boomsma, John Danesh, Mika Ala-Korpela, Adam S Butterworth, Johannes Kettunen
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1-7 . This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8-11 . Here we present a genome-wide association study for 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up to 136,016 participants from 33 cohorts...
March 6, 2024: Nature
https://read.qxmd.com/read/38441603/association-between-fetal-fraction-of-cell-free-dna-and-adverse-pregnancy-outcomes
#12
JOURNAL ARTICLE
Hakan Golbasi, Burak Bayraktar, Ceren Golbasi, Ibrahim Omeroglu, Duygu Adiyaman, Kaan Okan Alkan, Taha Resid Ozdemir, Ozge Kaya Ozer, Berk Ozyilmaz, Atalay Ekin
PURPOSE: To determine the association between fetal fraction (FF) levels in cell-free fetal DNA (cffDNA) testing and adverse pregnancy outcomes. METHODS: This retrospective cohort study, conducted at a single center, involved 2063 pregnant women with normal 1st and 2nd trimester non-invasive prenatal test (NIPT) results between 2016 and 2021. Pregnancy outcomes were examined by determining the  < 4% and  < 5th percentile (3.6%) cut-off values for low fetal fraction (LFF)...
March 5, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38432888/clinical-characteristics-of-bronchopulmonary-dysplasia-in-very-preterm-infants
#13
JOURNAL ARTICLE
Yonghui Yang, Xiaori He, Xuefei Zhang, Pingyang Chen
OBJECTIVES: With the development of perinatal and neonatal intensive care medicine, the survival rate of very premature infants increases year by year. However, the incidence of bronchopulmonary dysplasia (BPD) increases year by year, which seriously affects the survival prognosis of very premature infants. How to prevent and treat BPD effectively has become the focus of neonatologists. This study aims to provide ideas for the prevention and treatment of BPD in very preterm infants via analyzing the clinical characteristics of BPD...
October 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38429774/gestational-diabetes-mellitus-aggravates-adverse-perinatal-outcomes-in-women-with-intrahepatic-cholestasis-of-pregnancy
#14
JOURNAL ARTICLE
Xia Li, Qin-Yu Cai, Xin Luo, Yong-Heng Wang, Li-Zhen Shao, Shu-Juan Luo, Lan Wang, Ying-Xiong Wang, Xia Lan, Tai-Hang Liu
PURPOSE: To evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) with gestational diabetes mellitus (GDM) on perinatal outcomes and establish a prediction model of adverse perinatal outcomes in women with ICP. METHODS: This multicenter retrospective cohort study included the clinical data of 2,178 pregnant women with ICP, including 1,788 women with ICP and 390 co-occurrence ICP and GDM. The data of all subjects were collected from hospital electronic medical records...
March 1, 2024: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/38423120/history-of-cholestasis-is-not-associated-with-worsening-outcomes-in-subsequent-pregnancy-with-cholestasis
#15
JOURNAL ARTICLE
Minhazur Sarker, Chelsea Ann DeBolt, Dana Canfield, Lauren Ferrara
Intrahepatic cholestasis of pregnancy is associated with adverse pregnancy outcomes including intrauterine fetal demise, spontaneous preterm labor, and meconium-stained amniotic fluid. Studies have yet to determine if patients with a history of pregnancy complicated by cholestasis had an association with more adverse outcomes in a subsequent pregnancy complicated by cholestasis.   Study Design. Retrospective cohort study of multiparous, singleton, non-anomalous live gestations complicated by cholestasis at Elmhurst Hospital Center from 2005-2019...
February 29, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38418993/factors-influencing-necrotizing-enterocolitis-in-premature-infants-in-china-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Shuliang Zhao, Huimin Jiang, Yiqun Miao, Wenwen Liu, Yanan Li, Hui Liu, Aihua Wang, Xinghui Cui, Yuanyuan Zhang
BACKGROUND: Necrotizing enterocolitis (NEC) is a multifactorial gastrointestinal disease with high morbidity and mortality among premature infants. However, studies with large samples on the factors of NEC in China have not been reported. This meta-analysis aims to systematically review the literature to explore the influencing factors of necrotizing enterocolitis in premature infants in China and provide a reference for the prevention of NEC. METHODS: PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), Wanfang and VIP databases were systematically searched from inception to February 2023...
February 29, 2024: BMC Pediatrics
https://read.qxmd.com/read/38411871/liver-imaging-and-pregnancy-what-to-expect-when-your-patient-is-expecting
#17
REVIEW
Giorgia Porrello, Roberto Cannella, Jacques Bernuau, Antoine Agman, Giuseppe Brancatelli, Marco Dioguardi Burgio, Valérie Vilgrain
Liver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve the maternal liver and guarantee materno-fetal survival. While detailed questioning of the patient and a clinical examination are highly important, imaging is often essential to reach a diagnosis of these liver diseases and lesions. Three groups of liver diseases may be observed during pregnancy: (1) diseases related to pregnancy: intrahepatic cholestasis of pregnancy, pre-eclampsia, eclampsia, hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, and acute fatty liver of pregnancy; (2) liver diseases that are more frequent during or exacerbated by pregnancy: acute herpes simplex hepatitis, Budd-Chiari syndrome, hemorrhagic hereditary telangiectasia, hepatocellular adenoma, portal vein thrombosis, and cholelithiasis; (3) coincidental conditions, including acute hepatitis, incidental focal liver lesions, metabolic dysfunction-associated steatotic liver disease, cirrhosis, hepatocellular carcinoma, liver abscesses and parasitosis, and liver transplantation...
February 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38403070/gradual-dosing-of-ursodeoxycholic-acid-in-mothers-with-intrahepatic-cholestasis-of-pregnancy-may-improve-composite-neonatal-outcome
#18
JOURNAL ARTICLE
Amir Hamud, Matan J Cohen, Drorith Hochner-Celnikier, Benjamin Bar-Oz, Zvi Ackerman
INTRODUCTION AND OBJECTIVES: Intrahepatic cholestasis of pregnancy (ICP) is often accompanied by fetal and maternal complications. MATERIALS AND METHODS: Retrospective review of the clinical course of women with ICP and their neonates treated at our medical center over a 10-year period. Special attention was paid to the maternal and neonatal response to 2 different modes of ursodeoxycholic acid (UDCA) administration. RESULTS: Neonates of mothers with high total bile acid levels had a poorer composite neonatal outcome...
February 23, 2024: Annals of Hepatology
https://read.qxmd.com/read/38389228/-guidelines-for-clinical-diagnosis-treatment-and-management-of-intrahepatic-cholestasis-of-pregnancy-2024
#19
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 25, 2024: Zhonghua Fu Chan Ke za Zhi
https://read.qxmd.com/read/38384504/a-study-on-the-relationship-between-gut-microbiota-and-intrahepatic-cholestasis-of-pregnancy
#20
JOURNAL ARTICLE
Li-Wen Liu, Yan Chen, Liu-Jing Zhu, Qun-Xiang Xu, Shaolin Xu, Yanling Ding, Biao Yin
OBJECTIVE: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with a high incidence of complications in the mid and late stages of gestation. This study investigates differences in the composition of intestinal flora among pregnant women diagnosed with ICP, employing Illumina MiSeq high-throughput sequencing technology. METHODS: This case-control study obtained patient data from the hospital information system (HIS) and the laboratory information system (LIS)...
February 29, 2024: Heliyon
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