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https://www.readbyqxmd.com/read/28919255/sumo-proteins-guardians-of-immune-system
#1
REVIEW
Sabrina Adorisio, Alessandra Fierabracci, Isabella Muscari, Anna Marina Liberati, Emira Ayroldi, Graziella Migliorati, Trinh Thi Thuy, Carlo Riccardi, Domenico V Delfino
Small ubiquitin-like modifier (SUMO) proteins belong to the ubiquitin-like family and act to change the function of target proteins through post-translational modifications. Through their interactions with innate immune pathways, SUMOs promote an efficient immune response to pathogenic challenge avoiding, at the same time, an excess of immune response that could lead to the development of autoimmune diseases. This report discusses the general functions of SUMO proteins; highlights SUMO involvement in the innate immune response through their role in NF-κB and interferon pathways; the involvement of SUMO proteins in autoimmune diseases; and reviews bacterial, viral, and parasitic interactions with SUMO pathways...
September 14, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28918078/assessment-of-environmental-impacts-and-operational-costs-of-the-implementation-of-an-innovative-source-separated-urine-treatment
#2
Elorri Igos, Mathilde Besson, Tomás Navarrete Gutiérrez, Ana Barbara Bisinella de Faria, Enrico Benetto, Ligia Barna, Aras Ahmadi, Mathieu Spérandio
Innovative treatment technologies and management methods are necessary to valorise the constituents of wastewater, in particular nutrients from urine (highly concentrated and can have significant impacts related to artificial fertilizer production). The FP7 project, ValuefromUrine, proposed a new two-step process (called VFU) based on struvite precipitation and microbial electrolysis cell (MEC) to recover ammonia, which is further transformed into ammonium sulphate. The environmental and economic impacts of its prospective implementation in the Netherlands were evaluated based on life cycle assessment (LCA) methodology and operational costs...
September 8, 2017: Water Research
https://www.readbyqxmd.com/read/28912134/zatt-znf451-mediated-resolution-of-topoisomerase-2-dna-protein-cross-links
#3
Matthew J Schellenberg, Jenna Ariel Lieberman, Andrés Herrero-Ruiz, Logan R Butler, Jason G Williams, Ana M Muñoz-Cabello, Geoffrey A Mueller, Robert E London, Felipe Cortés-Ledesma, R Scott Williams
Topoisomerase 2 (TOP2) DNA transactions are essential for life, and proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by potent anticancer TOP2 drugs. How genotoxic TOP2 DNA-protein cross-links are resolved is unclear. We found that the SUMO ligase ZATT (ZNF451) is a multifunctional DNA repair factor that controls cellular responses to TOP2 damage. ZATT binding to TOP2cc facilitates a proteasome-independent tyrosyl-DNA phosphodiesterase 2 (TDP2) hydrolase activity on stalled TOP2cc...
September 14, 2017: Science
https://www.readbyqxmd.com/read/28911869/degradation-of-nuclear-ubc9-induced-by-listeriolysin-o-is-dependent-on-k-efflux
#4
Jiexin Li, Wendy Wai-Ling Lam, Tsz-Wah Lai, Shannon Wing-Ngor Au
Listeriolysin O (LLO) is a pore-forming toxin produced by L. monocytogenes, and is belonged to a protein family of cholesterol-dependent cytolysins (CDCs). Previous studies have demonstrated that LLO triggers Ubc9 degradation and disrupts host SUMOylation to facilitate bacterial infection. However, the underlying mechanism of Ubc9 degradation is unclear. Here we show that LLO-induced down-regulation of Ubc9 is independent of Ubc9-SUMO interaction, however, it may involve phosphorylation signaling. Additionally, LLO exerts its effects primarily on nuclear Ubc9 and this process is mediated by K(+) efflux...
September 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28903074/siz1-mediated-sumoylation-during-phosphate-homeostasis-in-plants-looking-beyond-the-tip-of-the-iceberg
#5
REVIEW
Manali Datta, Sanket Kaushik, Anupam Jyoti, Nidhi Mathur, Shanker L Kothari, Ajay Jain
Availability of phosphate (Pi) is often limited in rhizospheres in different agroclimatic zones and adversely affects growth and development of plants. To circumvent this impasse, there is an urgent need and global consensus to develop Pi use efficient crops. To achieve this goal, it is essential to identify the molecular entities that exert regulatory influences on the sensing and signaling cascade governing Pi homeostasis. SIZ1 encodes a small ubiquitin-like modifier (SUMO E3) ligase, and plays a pivotal role in the post-translational SUMOylation of proteins...
September 10, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28903035/functional-insights-into-anp32a-dependent-influenza-a-virus-polymerase-host-restriction
#6
Patricia Domingues, Benjamin G Hale
Host restriction of influenza A virus limits pandemic emergence. The viral RNA polymerase (vPol) is an essential enzyme that must adapt for avian viruses to replicate in humans. Species differences in host ANP32A dictate adaptation: human ANP32A lacks an uncharacterized 33 amino-acid insertion that is present in avian ANP32A. Here, we uncover important contributions of host SUMOylation to vPol activity, including avANP32A function. We also identify a hydrophobic SUMO interaction motif (SIM)-like sequence unique to avANP32A that critically supports avian-signature vPol...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28902364/functional-roles-of-c-ebp%C3%AE-and-sumo%C3%A2-modification-in-lung-development
#7
Yuan-Dong Chen, Jiang-Yan Liu, Yan-Min Lu, Hai-Tao Zhu, Wei Tang, Qiu-Xia Wang, Hong-Yan Lu
CCAAT enhancer binding protein alpha (C/EBPα) is a transcription factor regulating the core aspects of cell growth and differentiation. The present study investigated the level and functional role of C/EBPα during the development of the rat lung. C/EBPα protein exhibits a dynamic expression pattern. The correlation between the expression of C/EBPα protein and the content of glycogen during lung maturation was analyzed to understand the function of C/EBPα in lung differentiation. The high expression of C/EBPα coincides with the reduction of glycogen in the fetal lung...
August 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28901483/moderate-hypothermia-induces-protein-sumoylation-in-bone-marrow-stromal-cells-and-enhances-their-tolerance-to-hypoxia
#8
Wenbo Ren, Xiaofang Ma, Xiaozhi Liu, Yanxia Li, Zhongmin Jiang, Yujun Zhao, Chen Li, Xin Li
Acute cerebral infarction can progress rapidly, and there are limited specific and effective treatments. Small ubiquitin‑like modifiers (SUMOs) provide an important post‑translational modification of proteins. Following cerebral infarction, multiple proteins can combine with SUMOs to protect nerve cells. Furthermore, moderate hypothermia (core body temperature, 33‑34˚C) can increase the level of SUMOylation on multiple proteins. In the present study, it was examined whether moderate hypothermia increases the survival rate of bone marrow stromal stem cells (BMSCs) implanted in the cerebral ischemic penumbra via SUMOylation of multiple proteins...
September 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900032/nucleolar-and-spindle-associated-protein-1-nusap1-interacts-with-a-sumo-e3-ligase-complex-during-chromosome-segregation
#9
Christine A Mills, Aussie Suzuki, Anthony Arceci, Jin Yao Mo, Alex Duncan, Edward D Salmon, Michael J Emanuele
The mitotic spindle is composed of dynamic microtubules and associated proteins that together direct chromosome movement during mitosis. The spindle plays a vital role in accurate chromosome segregation fidelity and is a therapeutic target in cancer. Nevertheless, the molecular mechanisms by which many spindle associated proteins function remains unknown. The Nucleolar and Spindle Associated Protein NUSAP1 is a microtubule binding protein implicated in spindle stability and chromosome segregation. We show here that NUSAP1 localizes to dynamic spindle microtubules in a unique chromosome-centric pattern, in the vicinity of overlapping microtubules, during metaphase and anaphase of mitosis...
September 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28899943/the-chromatin-remodeling-isw1a-complex-is-regulated-by-sumoylation
#10
Qingtang Shen, Nissrine Beyrouthy, Laura Matabishi-Bibi, Catherine Dargemont
The ISWI class of proteins consists in a family of chromatin remodeling ATPases that is ubiquitous in eukaryotes and predominantly functions to slide nucleosomes laterally. The yeast Saccharomyces cerevisiae Isw1 partners with several non-essential alternative subunits-Ioc2, Ioc3, or Ioc4-to form two distinct complexes Isw1a and Isw1b. Besides its ATPase domain, Isw1 presents a C-terminal region formed by HAND, SANT and SLIDE domains responsible for interaction with the Ioc proteins and optimal association of Isw1 to chromatin...
September 12, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28895115/sumoylation-of-suvr2-contributes-to-its-role-in-transcriptional-gene-silencing
#11
Yu-Xi Luo, Yong-Feng Han, Qiu-Yuan Zhao, Jin-Lu Du, Kun Dou, Lin Li, She Chen, Xin-Jian He
The SU(VAR)-3-9-related protein family member SUVR2 has been previously identified to be involved in transcriptional gene silencing both in RNA-dependent and -independent pathways. It interacts with the chromatin-remodeling proteins CHR19, CHR27, and CHR28 (CHR19/27/28), which are also involved in transcriptional gene silencing. Here our study demonstrated that SUVR2 is almost fully mono-sumoylated in vivo. We successfully identified the exact SUVR2 sumoylation site by combining in vitro mass spectrometric analysis and in vivo immunoblotting confirmation...
September 8, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28892090/probing-the-roles-of-sumoylation-in-cancer-cell-biology-by-using-a-selective-sae-inhibitor
#12
Xingyue He, Jessica Riceberg, Teresa Soucy, Erik Koenig, James Minissale, Melissa Gallery, Hugues Bernard, Xiaofeng Yang, Hua Liao, Claudia Rabino, Pooja Shah, Kristina Xega, Zhong-Hua Yan, Mike Sintchak, John Bradley, He Xu, Matt Duffey, Dylan England, Hirotake Mizutani, Zhigen Hu, Jianping Guo, Ryan Chau, Lawrence R Dick, James E Brownell, John Newcomb, Steve Langston, Eric S Lightcap, Neil Bence, Sai M Pulukuri
Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification. However, a potent and selective inhibitor targeting the SUMO pathway has been lacking. Here we describe ML-792, a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation. Moreover, we found that induction of the MYC oncogene increased the ML-792-mediated viability effect in cancer cells, thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors...
September 11, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28888063/sumo-co-expression-modifies-kv-11-1-channel-activity
#13
Annette Buur Steffensen, Martin Nybo Andersen, Nancy Mutsaers, Amer Mujezinovic, Nicole Schmitt
AIM: The voltage-gated potassium channel KV 11.1 is the molecular basis for the IKr current which plays an important role in cardiac physiology. Its malfunction is associated with both inherited and acquired cardiac arrhythmias. Native currents differ from those in experimental models, suggesting additional regulatory mechanisms. We hypothesised that the post-translational modification sumoylation finetunes channel activity. METHODS: The functional effects of sumoylation on KV 11...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28884683/characterisation-of-the-biflavonoid-hinokiflavone-as-a-pre-mrna-splicing-modulator-that-inhibits-senp
#14
Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard Hartley, Angus I Lamond
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, leading to accumulation of the A complex. Cells treated with hinokiflavone show altered subnuclear organization specifically of splicing factors required for A complex formation, which relocalize together with SUMO1 and SUMO2 into enlarged nuclear speckles...
September 8, 2017: ELife
https://www.readbyqxmd.com/read/28883038/yeast-silencing-factor-sir4-and-a-subset-of-nucleoporins-form-a-complex-distinct-from-nuclear-pore-complexes
#15
Diego L Lapetina, Christopher Ptak, Ulyss K Roesner, Richard W Wozniak
Interactions occurring at the nuclear envelope (NE)-chromatin interface influence both NE structure and chromatin organization. Insights into the functions of NE-chromatin interactions have come from the study of yeast subtelomeric chromatin and its association with the NE, including the identification of various proteins necessary for tethering subtelomeric chromatin to the NE and the silencing of resident genes. Here we show that four of these proteins-the silencing factor Sir4, NE-associated Esc1, the SUMO E3 ligase Siz2, and the nuclear pore complex (NPC) protein Nup170-physically and functionally interact with one another and a subset of NPC components (nucleoporins or Nups)...
September 7, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28878795/organization-and-regulation-of-soybean-sumoylation-system-under-abiotic-stress-conditions
#16
Yanjun Li, Guixin Wang, Zeqian Xu, Jing Li, Mengwei Sun, Jingsong Guo, Wei Ji
Covalent attachment of the small ubiquitin-related modifier, SUMO, to substrate proteins plays a significant role in plants under stress conditions, which can alter target proteins' function, location, and protein-protein interactions. Despite this importance, information about SUMOylation in the major legume crop, soybean, remains obscure. In this study, we performed a bioinformatics analysis of the entire soybean genome and identified 40 genes belonged to six families involved in a cascade of enzymatic reactions in soybean SUMOylation system...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28874810/innate-immune-activating-ligand-sumoylation-affects-tumor-cell-recognition-by-nk-cells
#17
Beatrice Zitti, Rosa Molfetta, Cinzia Fionda, Linda Quatrini, Helena Stabile, Mario Lecce, Valeria de Turris, Maria Rosaria Ricciardi, Maria Teresa Petrucci, Marco Cippitelli, Angela Gismondi, Angela Santoni, Rossella Paolini
Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on transcriptional mechanisms, while the involvement of ubiquitin or ubiquitin-like modifiers remains largely unexplored. Here, we focused on the SUMO pathway and demonstrated that the ligand of DNAM1 activating receptor, PVR, undergoes SUMOylation in multiple myeloma...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874462/%C3%AE-arrestin2-improves-post-myocardial-infarction-heart-failure-via-sarco-endo-plasmic-reticulum-ca-2-atpase-dependent-positive-inotropy-in-cardiomyocytes
#18
Katie A McCrink, Jennifer Maning, Angela Vu, Malika Jafferjee, Christine Marrero, Ava Brill, Ashley Bathgate-Siryk, Samalia Dabul, Walter J Koch, Anastasios Lymperopoulos
Heart failure is the leading cause of death in the Western world, and new and innovative treatments are needed. The GPCR (G protein-coupled receptor) adapter proteins βarr (β-arrestin)-1 and βarr-2 are functionally distinct in the heart. βarr1 is cardiotoxic, decreasing contractility by opposing β1AR (adrenergic receptor) signaling and promoting apoptosis/inflammation post-myocardial infarction (MI). Conversely, βarr2 inhibits apoptosis/inflammation post-MI but its effects on cardiac function are not well understood...
September 5, 2017: Hypertension
https://www.readbyqxmd.com/read/28859974/novel-stat1-mutation-disrupts-small-ubiquitin-related-modifier-sumo-conjugation-causing-gain-of-function
#19
Elizabeth P Sampaio, Li Ding, Stacey R Rose, Phillip Cruz, Amy P Hsu, Anuj Kashyap, Lindsey B Rosen, Margery Smelkinson, Tatyana A Tavella, Elise M N Ferre, Meredith K Wierman, Christa S Zerbe, Michail S Lionakis, Steven M Holland
BACKGROUND: Sumoylation is a post-translational reversible modification of cellular proteins by the conjugation of SUMO (small ubiquitin-related modifier) and comprises an important regulator of protein function. OBJECTIVE: To characterize the molecular mechanism of a novel mutation at the SUMO motif on STAT1. METHODS: STAT1 sequencing and functional characterization were performed in transfection experiments using immunoblotting and immunoprecipitation in STAT1-deficient cell lines...
August 28, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28852381/soxc-transcription-factors-in-retinal-development-and-regeneration
#20
REVIEW
Kun-Che Chang, Jonathan Hertz
Glaucoma and other optic neuropathies result in optic nerve degeneration and the loss of retinal ganglion cells (RGCs) through complex signaling pathways. Although the mechanisms that regulate RGC development remain unclear, uncovering novel developmental pathways may support new strategies to regenerate the optic nerve or replace RGCs. Here we review recent studies that provide strong evidence that the Sry-related high-mobility-group C (SoxC) subfamily of transcription factors (TFs) are necessary and sufficient for axon guidance and RGC fate specification...
July 2017: Neural Regeneration Research
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