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https://www.readbyqxmd.com/read/28110067/poly-glycerol-sebacate-elastomer-supports-bone-regeneration-by-its-mechanical-properties-being-closer-to-osteoid-tissue-rather-than-to-mature-bone
#1
S H Zaky, K W Lee, J Gao, A Jensen, K Verdelis, Y Wang, A J Almarza, C Sfeir
: Mechanical load influences bone structure and mass. Arguing the importance of load-transduction, we investigated the mechanisms inducing bone formation using an elastomeric substrate. We characterized Poly (glycerol sebacate) (PGS) in-vitro for its mechanical properties, compatibility with osteoprogenitor cells regarding adhesion, proliferation, differentiation under compression versus static cultures and in-vivo for the regeneration of a rabbit ulna critical size defect. The load-transducing properties of PGS were compared in-vitro to a stiffer poly lactic-co- glycolic-acid (PLA/PGA) scaffold of similar porosity and interconnectivity...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28109797/evaluation-of-sleep-bruxism-with-a-novel-designed-occlusal-splint
#2
Kentaro Hirai, Tomoko Ikawa, Yuko Shigeta, Shuji Shigemoto, Takumi Ogawa
PURPOSE: This report presents our evaluation system that assesses sleep bruxism. The characteristics and fabrication process of our novel designed splint, and the analysis process of our system are presented. METHODS: The subjects were 17 volunteers. The splint was fabricated with a self-curing resin compounded with an amino-acid powder for easy wear on the semi-adjustable articulator, and adjusted for a full-balanced occlusion. An impression of the splint, located on the cast, was taken before and after it was worn...
January 18, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28109492/audiovisual-materials-are-effective-for-enhancing-the-correction-of-articulation-disorders-in-children-with-cleft-palate
#3
María Del Carmen Pamplona, Pablo Antonio Ysunza, Santiago Morales
INTRODUCTION: Children with cleft palate frequently show speech disorders known as compensatory articulation. Compensatory articulation requires a prolonged period of speech intervention that should include reinforcement at home. However, frequently relatives do not know how to work with their children at home. OBJECTIVE: To study whether the use of audiovisual materials especially designed for complementing speech pathology treatment in children with compensatory articulation can be effective for stimulating articulation practice at home and consequently enhancing speech normalization in children with cleft palate...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28108332/sex-dependent-effects-of-early-life-inflammatory-pain-on-sucrose-intake-and-sucrose-associated-hippocampal-arc-expression-in-adult-rats
#4
Yoko O Henderson, Rebecca Nalloor, Almira Vazdarjanova, Anne Z Murphy, Marise B Parent
We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory of a meal and inhibit the initiation of the next meal and the amount ingested during that meal. In support, we showed previously that (1) consuming a sucrose meal induces expression of the synaptic plasticity marker activity-regulated cytoskeleton-associated protein (Arc) in dHC neurons and (2) reversible inactivation of these neurons immediately following a sucrose meal accelerates the onset of the next meal and increases the size of that meal...
January 17, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28107130/the-use-of-miniscrews-in-orthodontics-a-review-of-selected-clinical-applications
#5
Eliakim Mizrahi
This paper provides a brief review of the history and development of mini screws and presents its structural features, with particular reference to the screw sizes relevant to clinical orthodontics, site selection and the different placement techniques. It covers the clinical applications of miniscrews, incorporating the principle of direct and indirect anchorage as well as the use of intraoral auxiliaries for distal movement of molars. The role of palatal miniscrews for retraction of anterior teeth, and when used in combination with buccal miniscrews for intrusion of buccal teeth is also covered along with the possible causes of miniscrew failure...
November 1, 2016: Primary Dental Journal
https://www.readbyqxmd.com/read/28106695/velopharyngeal-insufficiency-after-le-fort-i-osteotomy-in-a-patient-with-undiagnosed-occult-submucous-cleft-palate
#6
Rushil R Dang, Bonnie L Padwa, Cory M Resnick
The authors present a 16-year-old patient with no known history of cleft palate who developed velopharyngeal insufficiency after a Le Fort I osteotomy performed for the correction of maxillary hypoplasia and a Class III malocclusion. Postoperative evaluation revealed the presence of velopharyngeal insufficiency and subtle findings of an occult submucous cleft palate. She had a pharyngeal flap 6 months later with successful correction of the velopharyngeal insufficiency. This case illustrates the need to screen for submucous cleft palate prior to orthognathic surgery...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106628/neonatal-micrognathia-national-trends-in-early-mandibular-surgery
#7
Hillary E Jenny, Benjamin B Massenburg, E Hope Weissler, Peter J Taub
BACKGROUND: Micrognathia is a congenital anomaly that may pose breathing and feeding limitations in newborns, sometimes necessitating invasive management. The present study aims to identify the complications associated with receiving mandibular surgery during the birth stay in order to better predict which patients may benefit from early surgical intervention. METHODS: A retrospective cohort study was performed using the 2000 to 2012 kids' inpatient databases. We included all live newborn infants born in the hospital through vaginal delivery or caesarean section...
January 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28106045/identification-of-shared-and-unique-gene-families-associated-with-oral-clefts
#8
Noriko Funato, Masataka Nakamura
Oral clefts, the most frequent congenital birth defects in humans, are multifactorial disorders caused by genetic and environmental factors. Epidemiological studies point to different etiologies underlying the oral cleft phenotypes, cleft lip (CL), CL and/or palate (CL/P) and cleft palate (CP). More than 350 genes have syndromic and/or nonsyndromic oral cleft associations in humans. Although genes related to genetic disorders associated with oral cleft phenotypes are known, a gap between detecting these associations and interpretation of their biological importance has remained...
January 20, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28106044/root-canal-morphology-and-configuration-of-123-maxillary-second-molars-by-means-of-micro-ct
#9
Thomas Gerhard Wolf, Frank Paqué, Anja-Christin Woop, Brita Willershausen, Benjamín Briseño-Marroquín
The aim of this study was to investigate the root canal configuration, accessory canals and number of main foramina of 123 maxillary second molars by means of micro-computed tomography. The teeth were scanned and reproduced with 3D software imaging. The root canal configuration and number of main foramina were evaluated by means of a four-digit system. The morphological complexity of human maxillary second molars is depicted by the number of accessory and connecting canals. The most frequently observed root canal configurations in the mesiobuccal root were 2-2-2/2 (19...
January 20, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28105667/palatoglossus-coupling-in-selective-upper-airway-stimulation
#10
Clemens Heiser, Günther Edenharter, Murat Bas, Markus Wirth, Benedikt Hofauer
OBJECTIVES/HYPOTHESIS: Selective upper airway stimulation (sUAS) of the hypoglossal nerve is a useful therapy to treat patients with obstructive sleep apnea. Is it known that multiple obstructions can be solved by this stimulation technique, even at the retropalatal region. The aim of this study was to verify the palatoglossus coupling at the soft palate during stimulation. STUDY DESIGN: Single-center, prospective clinical trail. METHODS: Twenty patients who received an sUAS implant from April 2015 to April 2016 were included...
January 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28105590/case-report-on-managing-incomplete-bone-formation-after-bilateral-sinus-augmentation-using-a-palatal-approach-and-a-dilating-balloon-technique
#11
Tobias K Boehm
BACKGROUND: Patients with resorbed edentulous alveolar ridges in the posterior maxilla often require lateral window sinus augmentation procedures prior to implant placement. Lateral window sinus augmentation procedures can produce incomplete bone augmentation as consequence of surgical and healing complications producing unusual and complex sinus anatomy. Although incomplete bone formation after sinus augmentation has been described in a previous case reports, this is the first case report that describes grafting these compromised sites prior to implant placement...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28103846/a-description-of-interventions-promoting-healthier-ready-to-eat-meals-to-eat-in-to-take-away-or-to-be-delivered-sold-by-specific-food-outlets-in-england-a-systematic-mapping-and-evidence-synthesis
#12
Frances C Hillier-Brown, Carolyn D Summerbell, Helen J Moore, Wendy L Wrieden, Jean Adams, Charles Abraham, Ashley Adamson, Vera Araújo-Soares, Martin White, Amelia A Lake
BACKGROUND: Ready-to-eat meals (to eat in, to take away or to be delivered) sold by food outlets are often more energy dense and nutrient poor compared with meals prepared at home, making them a reasonable target for public health intervention. The aim of the research presented in this paper was to systematically identify and describe interventions to promote healthier ready-to-eat meals (to eat in, to take away, or to be delivered) sold by specific food outlets in England. METHODS: A systematic search and sift of the literature, followed by evidence mapping of relevant interventions, was conducted...
January 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28102940/effect-of-cast-modification-on-denture-base-adaptation-following-maxillary-complete-denture-processing
#13
Mohammed E Sayed, Amit Porwal, David Ehrenberg, Saul Weiner
PURPOSE: To investigate the effect of cast modifications on denture base adaptation in coronal and sagittal projections following maxillary complete denture processing. MATERIALS AND METHODS: A total of 60 edentulous maxillary casts (n = 10) were distributed among six groups. Group 1 was the control group with no modification, groups 2 through 6 included a butterfly postdam preparation, groups 3 and 4 also included a 10-mm wide/4-mm deep box with addition of four round holes in group 4, and groups 5 and 6 also included a 20-mm wide/4-mm deep box with addition of four round holes in group 6...
January 19, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28102598/novel-findings-of-left-ventricular-non-compaction-cardiomyopathy-microform-cleft-lip-and-poor-vision-in-patient-with-smc1a-associated-cornelia-de-lange-syndrome
#14
Tara L Wenger, Penny Chow, Stephanie C Randle, Anna Rosen, Craig Birgfeld, Joanna Wrede, Patrick Javid, Darcy King, Vivian Manh, Anne V Hing, Erin Albers
Relatively few patients with Cornelia de Lange syndrome (CdLS) due to SMC1A mutation have been reported, limiting understanding of the full extent of the phenotype. Compared to children with classic NIPBL-associated CdLS, patients with SMC1A-associated CdLS have a milder physical phenotype with prominent intellectual disability, high rate of cleft palate and absence of limb reductions. We present a patient with SMC1A-associated CdLS who had typical features including developmental delay, seizure disorder, feeding difficulties, hirsutism, and cleft palate...
February 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28102014/phonetic-analysis-during-treatment-with-rapid-maxillary-expander
#15
E Biondi, A Bandini, L Lombardo, S Orlandi, G Siciliani, C Manfredi
OBJECTIVES: To investigate possible changes and/or device-related impairments in phonetic habits produced by rapid maxillary expansion (RME). MATERIALS AND METHODS: Thirty-five patients scheduled for RME were divided into two groups: Group A (banded two-arm Hyrax) and Group B (banded four-arm Hyrax). Speech samples were collected at six time points, before, during and after RME removal. Acoustical analysis was performed using PRAAT and BioVoice analysis tools. Ten volunteers completed a questionnaire on the acceptability of patient's speech...
February 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28102012/visual-perception-of-faces-with-unilateral-and-bilateral-cleft-lip-and-palate-an-eye-tracking-study
#16
Furkan Dindaroğlu, Servet Doğan, Sonia Amado, Ege Doğan
OBJECTIVES: To test the hypotheses that there are differences between orthodontists, individuals with cleft lip and palate (CLP) and laypersons in the visual perception of faces with unilateral (UCLP) and bilateral cleft lip and palate (BCLP), the faces with UCLP and BCLP are visually perceived differently and the hierarchy of visual attention changes when viewing individuals with CLP. SETTING AND SAMPLE POPULATION: Department of Orthodontics and Experimental Psychology at Ege University, İzmir...
February 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28101680/application-of-tissue-engineered-bone-grafts-for-alveolar-cleft-osteoplasty-in-a-rodent-model
#17
Paula Korn, Maria Hauptstock, Ursula Range, Christiane Kunert-Keil, Winnie Pradel, Günter Lauer, Matthias C Schulz
OBJECTIVES: The clinical standard for alveolar cleft osteoplasty is augmentation with autologous bone being available in limited amounts and might be associated with donor site morbidity. The aim of the present study was the creation of tissue-engineered bone grafts and their in vivo evaluation regarding their potential to promote osteogenesis in an alveolar cleft model. MATERIALS AND METHODS: Artificial bone defects with a diameter of 3.3 mm were created surgically in the palate of 84 adult Lewis rats...
January 18, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28100473/delineating-the-phenotypic-spectrum-of-bainbridge-ropers-syndrome-12-new-patients-with-de-novo-heterozygous-loss-of-function-mutations-in-asxl3-and-review-of-published-literature
#18
M Balasubramanian, J Willoughby, A E Fry, A Weber, H V Firth, C Deshpande, J N Berg, K Chandler, K A Metcalfe, W Lam, D Pilz, S Tomkins
BACKGROUND: Bainbridge-Ropers syndrome (BRPS) is a recently described developmental disorder caused by de novo truncating mutations in the additional sex combs like 3 (ASXL3) gene. To date, there have been fewer than 10 reported patients. OBJECTIVES: Here, we delineate the BRPS phenotype further by describing a series of 12 previously unreported patients identified by the Deciphering Developmental Disorders study. METHODS: Trio-based exome sequencing was performed on all 12 patients included in this study, which found a de novo truncating mutation in ASXL3...
January 18, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28100333/-streptococcus-pneumoniae-induces-splunc1-and-the-regulatory-effects-of-resveratrol
#19
Yan-Ping Shang, Li Lin, Chang-Chong Li
OBJECTIVE: To investigate the host-defense role of short palate, lung, and nasal epithelium clone 1 (SPLUNC1) in Streptococcus pneumoniae (SP) infection and the effect of resveratrol (Res) on SPLUNC1 expression, and to provide new thoughts for the treatment of diseases caused by SP infection. METHODS: According to the multiplicity of infection (MOI), BEAS-2B cells with SP infection were divided into control group, MOI20 SP group, and MOI50 SP group. According to the different concentrations of Res, the BEAS-2B cells with MOI20 SP infection pretreated by Res were divided into 12...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28099576/bpi-fold-bpif-containing-plunc-protein-expression-in-human-fetal-major-and-minor-salivary-glands
#20
Daniel Berretta Moreira Alves, Lynne Bingle, Colin David Bingle, Silvia Vanessa Lourenço, Andréia Aparecida Silva, Débora Lima Pereira, Pablo Agustin Vargas
The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry...
January 16, 2017: Brazilian Oral Research
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