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https://www.readbyqxmd.com/read/27931744/learning-from-one-s-mistakes-a-dual-role-for-the-rostromedial-tegmental-nucleus-in-the-encoding-and-expression-of-punished-reward-seeking
#1
Peter J Vento, Nathan W Burnham, Courtney S Rowley, Thomas C Jhou
BACKGROUND: Psychiatric disorders such as addiction and mania are marked by persistent reward seeking despite highly negative or aversive outcomes, but the neural mechanisms underlying this aberrant decision making are unknown. The recently identified rostromedial tegmental nucleus (RMTg) encodes a wide variety of aversive stimuli and sends robust inhibitory projections to midbrain dopamine neurons, leading to the hypothesis that the RMTg provides a brake to reward signaling in response to aversive costs...
October 21, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27930952/prevalence-and-psychosocial-correlates-of-food-addiction-in-persons-with-obesity-seeking-weight-reduction
#2
Ariana M Chao, Jena A Shaw, Rebecca L Pearl, Naji Alamuddin, Christina M Hopkins, Zayna M Bakizada, Robert I Berkowitz, Thomas A Wadden
INTRODUCTION: Food addiction is a controversial concept. The potential influence of food addiction on patients' psychosocial functioning and well-being has not been well established. The purpose of this study was to examine the relationships between psychosocial functioning (depressive symptoms and health-related quality of life [HRQOL]) and food addiction as measured by the Yale Food Addiction Scale (YFAS). We also explored whether food addiction contributed additional variance in explaining psychosocial functioning, beyond demographic and clinical factors (e...
November 23, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27922596/pathological-overeating-emerging-evidence-for-a-compulsivity-construct
#3
REVIEW
Catherine F Moore, Valentina Sabino, George F Koob, Pietro Cottone
Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical and psychiatric conditions such as forms of obesity and eating disorders. While feeding research is moving towards a better understanding of the proposed addictive properties of food, the components and the mechanisms contributing to compulsive eating are not yet clearly defined or understood. Current understanding highlights three elements of compulsive behavior as it applies to pathological overeating: 1) habitual overeating; 2) overeating to relieve a negative emotional state; and 3) overeating despite aversive consequences...
December 6, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27916279/insights-from-preclinical-choice-models-on-treating-drug-addiction
#4
REVIEW
Matthew L Banks, S Stevens Negus
Substance-use disorders are a global public health problem that arises from behavioral misallocation between drug use and more adaptive behaviors maintained by nondrug alternatives (e.g., food or money). Preclinical drug self-administration procedures that incorporate a concurrently available nondrug reinforcer (e.g., food) provide translationally relevant and distinct dependent measures of behavioral allocation (i.e., to assess the relative reinforcing efficacy of the drug) and behavioral rate (i.e., to assess motor competence)...
December 1, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27914629/cytoplasmic-fmr1-interacting-protein-2-is-a-major-genetic-factor-underlying-binge-eating
#5
Stacey L Kirkpatrick, Lisa R Goldberg, Neema Yazdani, R Keith Babbs, Jiayi Wu, Eric R Reed, David F Jenkins, Amanda F Bolgioni, Kelsey I Landaverde, Kimberly P Luttik, Karen S Mitchell, Vivek Kumar, W Evan Johnson, Megan K Mulligan, Pietro Cottone, Camron D Bryant
BACKGROUND: Eating disorders are lethal and heritable; however, the underlying genetic factors are unknown. Binge eating is a highly heritable trait associated with eating disorders that is comorbid with mood and substance use disorders. Therefore, understanding its genetic basis will inform therapeutic development that could improve several comorbid neuropsychiatric conditions. METHODS: We assessed binge eating in closely related C57BL/6 mouse substrains and in an F2 cross to identify quantitative trait loci associated with binge eating...
October 25, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27909324/food-addiction-and-obesity
#6
Carrie R Ferrario
No abstract text is available yet for this article.
January 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27902847/food-deprivation-facilitates-reinstatement-of-morphine-induced-conditioned-place-preference-role-of-intra-accumbal-dopamine-d2-like-receptors-in-associating-reinstatement-of-morphine-cpp-with-stress
#7
Fatemeh Sadeghzadeh, Vahab Babapour, Abbas Haghparast
The high rate of relapse to drug use is one of the main problems in the treatment of addiction. Stress plays the essential role in drug abuse and relapse; nevertheless, little is known about the mechanisms underlying stress and relapse. Accordingly, the effects of intra-accumbal administration of Sulpiride, as a dopamine D2-like receptor antagonist, on an ineffective morphine dose+food deprivation(FD)- and morphine priming-induced reinstatement of conditioned place preference (CPP). 104 adult male albino Wistar rats weighing 200-280g were bilaterally implanted by cannula into the nucleus accumbens (NAc)...
November 30, 2016: Synapse
https://www.readbyqxmd.com/read/27895485/adhd-and-present-hedonism-time-perspective-as-a-potential-diagnostic-and-therapeutic-tool
#8
REVIEW
S Weissenberger, M Klicperova-Baker, P Zimbardo, K Schonova, D Akotia, J Kostal, M Goetz, J Raboch, R Ptacek
The article draws primarily from the behavioral findings (mainly psychiatric and psychological observations) and points out the important relationships between attention-deficit/hyperactivity disorder (ADHD) symptoms and time orientation. Specifically, the authors argue that there is a significant overlap between the symptoms of ADHD and Present Hedonism. Present Hedonism is defined by Zimbardo's time perspective theory and assessed by Zimbardo Time Perspective Inventory. Developmental data on Present Hedonism of males and females in the Czech population sample (N=2201) are also presented...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27893229/measurement-invariance-of-the-yale-food-addiction-scale-2-0-across-gender-and-racial-groups
#9
Meagan M Carr, Pelin D Catak, Megan C Pejsa-Reitz, Karen K Saules, Ashley N Gearhardt
Food addiction describes a psychological and behavioral eating pattern that is similar to the experience of those compulsively taking drugs of abuse. Recent developments related to food addiction, including the development and validation of an updated measure (Yale Food Addiction Scale 2.0; Gearhardt, Corbin, & Brownell, 2016), have increased knowledge as to the prevalence and associated correlates of food addiction. However, less is known about the phenomenological experience of food addiction in diverse samples or how the existing measure of food addiction performs in heterogeneous samples...
November 28, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27877117/general-habit-propensity-relates-to-the-sensation-seeking-subdomain-of-impulsivity-but-not-obesity
#10
Anja Dietrich, Sanne de Wit, Annette Horstmann
According to dual-system theory, instrumental learning and performance depend on the balance between goal-directed and habitual action control. Overreliance on habits has been argued to characterize clinical conditions such as drug addiction or obsessive-compulsive disorder as well as obesity and excessive impulsivity. A tendency toward habitual action control in obesity has already been indicated in the food domain. However, impairments might not be restricted to eating behavior. This has been suggested by domain-general obesity-associated disturbances in executive function as well as alterations in corticostriatal circuits underlying the goal-directed and habitual systems...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27876789/allostasis-in-health-and-food-addiction
#11
Dirk De Ridder, Patrick Manning, Sook Ling Leong, Samantha Ross, Sven Vanneste
Homeostasis is the basis of modern medicine and allostasis, a further elaboration of homeostasis, has been defined as stability through change, which was later modified to predictive reference resetting. It has been suggested that pleasure is related to salience (behavioral relevance), and withdrawal has been linked to allostasis in addictive types. The question arises how the clinical and neural signatures of pleasure, salience, allostasis and withdrawal relate, both in a non-addicted and addicted state. Resting state EEGs were performed in 66 people, involving a food-addicted obese group, a non-food addicted obese group and a lean control group...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27859963/repeated-restraint-stress-exposure-during-early-withdrawal-accelerates-incubation-of-cue-induced-cocaine-craving
#12
Ryan M Glynn, J Amiel Rosenkranz, Marina E Wolf, Aaron Caccamise, Freya Shroff, Alyssa B Smith, Jessica A Loweth
A major challenge for treating cocaine addiction is the propensity for abstinent users to relapse. Two important triggers for relapse are cues associated with prior drug use and stressful life events. To study their interaction in promoting relapse during abstinence, we used the incubation model of craving and relapse in which cue-induced drug seeking progressively intensifies ('incubates') during withdrawal from extended-access cocaine self-administration. We tested rats for cue-induced cocaine seeking on withdrawal day (WD) 1...
November 11, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27852971/-yale-food-addiction-scale-review-of-literature
#13
Éva Erzsébet Magyar, Györgyi Csábi, Tamás Tényi, Dalma Tényi
INTRODUCTION: Food addiction is a condition presenting with a similar symptomatology to that of drug addiction, with an underlying individual sensitivity and special adaptation to certain foods, being consumed regularly. The concept of food addiction created one of the central issues in addiction research, owing to the pandemic spreading of obesity causing serious public health concerns. Development of an objective, standardized measuring tool of food addiction has become markedly necessary for both research and public health purposes...
2016: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/27852970/-food-addiction-as-a-new-behavioral-addiction
#14
Erika Eördögh, Mária Hoyer, Gábor Szeleczky
: Aim of review: To overview the new studies on food addiction and highlighting the analogies and differences between food and drug addiction. RESULTS: Recent studies on food addiction have demonstrated that the neurobiological circuits involved in the development of drug addiction also play a role in food consumption, and that the uptake of nutrients by the organism is under the control of numerous complicated peripheral and central signal-transducing networks...
2016: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/27837404/the-biology-of-addiction
#15
Brent MacNicol
In this narrative review, the neurobiological mechanisms underlying substance abuse and addiction are discussed with a particular emphasis on the mechanisms that promote ongoing use and relapse. Addiction is estimated to affect 10-15% or more of the adult population, including physicians. Genetic predisposition, psychological and environmental risk factors, the timing of exposure to the substance, the type of substance used, and the frequency of use influence the individual's susceptibility to addiction. Abused substances act on the brain's reward system, a neural circuit that produces pleasurable feelings in response to stimuli that promote survival, thereby modifying future behavior to seek out similar stimuli...
November 11, 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27824052/augmentation-of-heroin-seeking-following-chronic-food-restriction-in-the-rat-differential-role-for-dopamine-transmission-in-the-nucleus-accumbens-shell-and-core
#16
Tracey M D'Cunha, Emilie Daoud, Damaris Rizzo, Audrey Bishop, Melissa Russo, Gabrielle Mourra, Laurie Hamel, Firas Sedki, Uri Shalev
Caloric restriction during drug abstinence increases the risk for relapse in addicts. In rats, chronic food restriction during a period of withdrawal following heroin self-administration augments heroin seeking. The mechanisms underlying this effect are largely unknown. Here, we investigated the role of nucleus accumbens (NAc) shell and core dopamine (DA) in food restriction-induced augmentation of heroin seeking. Rats were trained to self-administer heroin (0.1 mg/kg/infusion) for 10 days. Next, rats were moved to the animal colony for a withdrawal period, during which rats were food restricted to 90% of their original body weight (FDR group) or given unrestricted access to food (sated group)...
November 8, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27821368/preferred-descriptions-for-loss-of-control-while-eating-and-weight-among-patients-with-binge-eating-disorder
#17
Christina A Roberto, Katharine Galbraith, Janet A Lydecker, Valentina Ivezaj, Rachel D Barnes, Marney A White, Carlos M Grilo
Patients with binge eating disorder (BED) typically also have excess weight, making them vulnerable to stigmatizing attitudes about mental illness and obesity. Further, one of the diagnostic features of BED is experiencing a loss of control during binge eating episodes. It is possible that patients feel negatively judged when clinicians assess for loss of control as it may activate stereotypes of patients with obesity lacking willpower. We developed a questionnaire to assess preferences for common loss of control descriptions and gathered data on preferences for weight-related terms among 46 patients with BED...
September 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27817910/sugars-exercise-and-health
#18
REVIEW
Roberto Codella, Ileana Terruzzi, Livio Luzi
BACKGROUND: There is a direct link between a variety of addictions and mood states to which exercise could be relieving. Sugar addiction has been recently counted as another binge/compulsive/addictive eating behavior, differently induced, leading to a high-significant health problem. Regularly exercising at moderate intensity has been shown to efficiently and positively impact upon physiological imbalances caused by several morbid conditions, including affective disorders. Even in a wider set of physchiatric diseases, physical exercise has been prescribed as a complementary therapeutic strategy...
October 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27817750/l-tetrahydropalmatine-reduces-nicotine-self-administration-and-reinstatement-in-rats
#19
Shamia L Faison, Charles W Schindler, Steven R Goldberg, Jia Bei Wang
BACKGROUND: The negative consequences of nicotine use are well known and documented, however, abstaining from nicotine use and achieving abstinence poses a major challenge for the majority of nicotine users trying to quit. l-Tetrahydropalmatine (l-THP), a compound extracted from the Chinese herb Corydalis, displayed utility in the treatment of cocaine and heroin addiction via reduction of drug-intake and relapse. The present study examined the effects of l-THP on abuse-related effects of nicotine...
November 7, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27816464/a-commentary-on-the-associations-among-food-addiction-binge-eating-disorder-and-obesity-overlapping-conditions-with-idiosyncratic-clinical-features
#20
Caroline Davis
This commentary discusses the evidence linking patterns of compulsive overeating, such as binge eating and grazing, with a putative psychopathological condition known commonly as 'food addiction'. It also addresses their distinctiveness as independent - albeit overlapping - clinical entities. Discussions focus largely on their respective clinical features and neuropsychobiological associations. Despite semantic issues about the appropriateness of the food-addiction label, there is accumulating evidence that some vulnerable individuals display addictive symptoms in relation to their consumption of certain highly rewarding foods...
November 2, 2016: Appetite
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