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https://www.readbyqxmd.com/read/29348897/interferon-%C3%AE-adjuvant-therapy-decreases-the-recurrence-of-early-clear-cell-renal-cell-carcinoma-and-improves-the-prognosis-of-chinese-patients
#1
Hang Yin, Cheng-Gong Liao, Jian-Guo Huang, Yong-Qiang Wang, Zheng Li, Lu-Lu Fan, Men-Long Qian, Nao Wan, Ning Lu
The survival time of patients with early clear cell renal cell carcinoma (ccRCC) is fairly long, but 20% to 30% of patients with localized tumors experience relapse, and the effect of IFN-α on survival has not been well studied in patients with early ccRCC. In this study, 208 patients with early ccRCC were treated with surgery, and 54 of the patients received IFN-α as adjuvant therapy. The remaining 115 patients were treated with surgery but not with IFN-α therapy. The primary endpoint was the recurrence rate, 20...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340307/a-patient-with-ckd-develops-cholestatic-liver-injury-during-a%C3%A2-clinical-trial
#2
Emma D A Wagener, Nao Souma, Alexander Hodakowski, Carlos Martinez, Patrick Fox, Rupal Mehta, Matthew J O'Brien, Maureen Bolon, Laura Kulik, Guang-Yu Yang, Tamara Isakova
No abstract text is available yet for this article.
January 2018: KI Reports
https://www.readbyqxmd.com/read/29336875/systems-pharmacology-dissection-of-the-anti-stroke-mechanism-for-the-chinese-traditional-medicine-xing-nao-jing
#3
Yuhua Chen, Yue Sun, Wende Li, Hong Wei, Tianlin Long, Hua Li, Quanhua Xu, Wei Liu
Xing-Nao-Jing (XNJ) is a well-known injection that has been extensively applied in clinical treatment of stroke in China. However, the underlying mechanism of clinical administration of XNJ in stroke remains unclear. In this study, a systems pharmacology strategy based on pharmacokinetic and pharmacodynamics data was applied to analyze the pharmacological effect of XNJ on stroke. Sixteen active compounds were filtered from XNJ through Drug-likeness (DL) and Brain-blood-barrier (BBB) evaluations. Ninety-four potential targets of these active components were identified by SysDT and SEA...
December 20, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29330587/posterior-reversible-encephalopathy-syndrome-with-spinal-cord-involvement-pres-sci-as-a-rare-complication-of-severe-diabetic-ketoacidosis-a-case-report-and-review-of-the-literature
#4
Jianfei Nao, Han Zhang, Si Wu, Xiaotian Zhang, Dongming Zheng
INTRODUCTION: In addition to diffuse brain oedema, diabetic ketoacidosis (DKA) can lead to ischaemic or haemorrhagic stroke, extrapontine myelinolysis, and sinovenous thrombosis. However, posterior reversible encephalopathy syndrome (PRES) and spinal cord oedema are rarely reported in patients with DKA. METHODS: We present a case of a 17-year-old-girl who developed headache, blurred vision, and paraplegia after her DKA was controlled. Sequential magnetic resonance (MR) scans of the brain and spinal cord were performed...
January 12, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29324533/multicenter-clinicopathological-study-of-high-grade-serous-carcinoma-presenting-as-primary-peritoneal-carcinoma
#5
Shinichi Komiyama, Yoshihiro Nishijima, Haruhiro Kondo, Hiroyuki Nomura, Satoshi Yamaguchi, Masayuki Futagami, Hiroharu Arai, Yoshihito Yokoyama, Nao Suzuki, Mikio Mikami, Kaneyuki Kubushiro, Daisuke Aoki, Yasuhiro Udagawa, Ryuichiro Nishimura
OBJECTIVE: We conducted a multicenter clinicopathological study to characterize patients with high-grade serous carcinoma presenting as primary peritoneal carcinoma (clinical PPC). METHODS: At 9 sites in Japan, patients with clinical PPC diagnosed according to Gynecologic Oncology Group criteria were enrolled retrospectively. The Gynecologic Oncology Group criteria allow for minor ovarian involvement by high-grade serous carcinoma. There was no systematic detailed histopathological review of the fallopian tubes to determine whether they were involved by serous carcinoma...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29323162/high-co-expression-of-il-34-and-m-csf-correlates-with-tumor-progression-and-poor-survival-in-lung-cancers
#6
Muhammad Baghdadi, Hiraku Endo, Atsushi Takano, Kozo Ishikawa, Yosuke Kameda, Haruka Wada, Yohei Miyagi, Tomoyuki Yokose, Hiroyuki Ito, Haruhiko Nakayama, Yataro Daigo, Nao Suzuki, Ken-Ichiro Seino
Despite recent advances in diagnosis and treatment of lung cancers, the 5-year survival rate remains unsatisfactory, which necessitates the identification of novel factors that associates with disease progression and malignant degree for improving diagnostic and therapeutic strategies. Recent progress in cancer immunology research has unveiled critical roles for colony stimulating factor 1 receptor (CSF1R) in multiple aspects of the tumor microenvironment. CSF1R is expressed on tumor-associated macrophages (TAMs), and mediates important pro-tumorigenic functions...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321403/a-patient-with-a-massive-single-cardiac-metastasis-of-lung-adenocarcinoma-diagnosed-via-a-biopsy-a-case-report
#7
Takuya Oyakawa, Nao Muraoka, Kei Iida, Masatoshi Kusuhara, Tateaki Naito
A patient with a history of lung adenocarcinoma was admitted because of palpitation. Transthoracic echocardiogram revealed a mass (74×42 mm) in the right ventricle. Computed tomography showed a tumor lesion in the right ventricular cavity but no other distant metastasis. Coronary angiography revealed well-developed small branches to the tumor. After right heart catheterization, a pathological analysis of a tumor biopsy demonstrated adenocarcinoma. We diagnosed the patient with right ventricular metastasis of lung cancer...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29300912/characteristics-of-cellular-composition-in-malignant-pericardial-effusion-and-its-association-with-the-clinical-course-of-carcinomatous-pericarditis
#8
Takuya Oyakawa, Nao Muraoka, Kei Iida, Masatoshi Kusuhara, Tateaki Naito, Katsuhiro Omae
To date, the cellular composition of malignant pericardial effusion (MPE) and its association with the clinical course of carcinomatous pericarditis remain unclear. We aimed to determine the MPE cellular composition and its association with carcinomatous pericarditis. Forty-four cases indicated for pericardial drainage due to symptomatic carcinomatous pericarditis were retrospectively reviewed; the blood cell count and composition of MPE were examined. The most dominant cells in MPE were neutrophils. The appearance ratio of an atypical cell in cytologically positive MPE was 95...
December 29, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29300901/aromatase-inhibitor-use-during-ovarian-stimulation-suppresses-growth-of-uterine-endometrial-cancer-in-xenograft-mouse-model
#9
Tai Kawahara, Naoki Okamoto, Seido Takae, Megumi Kashiwagi, Mariko Nakajima, Atsushi Uekawa, Junya Ito, Naomi Kashiwazaki, Yodo Sugishita, Nao Suzuki
STUDY QUESTION: Could aromatase inhibitors (AI) be used to reduce risks of uterine endometrial cancer growth or recurrence during ovarian stimulation? SUMMARY ANSWER: In a xenograft mouse model of endometrial cancer, concomitant AI administration suppressed the growth of endometrial cancer during ovarian stimulation. WHAT IS KNOWN ALREADY: Recurrence and mortality rates of estrogen receptor-positive early breast cancer are reduced by long-term AI administration...
December 28, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29288691/a-prospective-study-of-the-impact-of-diabetes-mellitus-on-restrictive-and-obstructive-lung-function-impairment-the-saku-study
#10
Nao Sonoda, Akiko Morimoto, Yukako Tatsumi, Kei Asayama, Takayoshi Ohkubo, Satoshi Izawa, Yuko Ohno
BACKGROUND: To assess the impact of diabetes on restrictive and obstructive lung function impairment. METHODS: This 5-year prospective study included 7524 participants aged 40-69years without lung function impairment at baseline who underwent a comprehensive medical check-up between April 2008 and March 2009 at Saku Central Hospital. Diabetes was defined by fasting plasma glucose ≥7.0mmol/l (126mg/dl), HbA1c≥6.5% (48mmol/mol), or a history of diabetes, as determined by interviews conducted by the physicians...
December 28, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29288517/proposal-for-the-development-of-biologics-in-pediatric-rheumatology-field
#11
REVIEW
Masaaki Mori, Masao Nakagawa, Nao Tsuchida, Kou Kawada, Junko Sato, Michiyo Sakiyama, Shinya Hirano, Katsuaki Sato, Hidefumi Nakamura
In order to aim at the development, approval and early introduction into clinical practice of biologics in pediatric field, we investigated the present situation of the development to approval of biologics as anti-rheumatic agents for children in Japan, visualize the present problems and give a proposal for the future. As results of analysis in various directions, it is apparent that the duration of a review period required for the preparation of clinical trials and the approval in PMDA clearly reduced compared with the past...
December 29, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29280493/the-effects-of-concurrent-chemoradiation-therapy-to-the-base-of-tongue-in-a-preclinical-model
#12
Peter A Benedict, Ryan Ruiz, Avanti Verma, Gregory R Dion, Philmo Oh, Binhuan Wang, Omar H Ahmed, Nao Hiwatashi, Renjie Bing, Kristen Victor, Kenneth S Hu, Aaron Johnson, Ryan C Branski, Milan R Amin
OBJECTIVES/HYPOTHESIS: To develop a clinically relevant model of oropharyngeal concurrent chemoradiation therapy (CCRT) in order to quantify the effects of CCRT on tongue function and structure. CCRT for advanced oropharyngeal cancer commonly leads to tongue base dysfunction and dysphagia. However, no preclinical models currently exist to study the pathophysiology of CCRT-related morbidity, thereby inhibiting the development of targeted therapeutics. STUDY DESIGN: Animal model...
December 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29279052/congenital-basal-meningoceles-with-different-outcomes-a-case-series
#13
Satomi Okano, Ryosuke Tanaka, Akie Okayama, Etsushi Tsuchida, Fumikatsu Nohara, Nao Suzuki, Toshio Okamoto, Ken Nagaya, Satoru Takahashi, Hiroshi Azuma
BACKGROUND: Basal meningoceles are rare congenital defects and often clinically occult until they result in life-threatening complications. Therefore, it is important to know the diagnostic clues to early diagnosis. CASE PRESENTATION: We describe three cases of congenital basal meningocele in a 3-year-old Japanese boy, a 1-month-old Japanese baby boy, and a 10-month-old Japanese baby girl. One of our patients died of sepsis due to traumatic rupture of the meningocele during nasal suction...
December 27, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29274615/latent-semantic-analysis-a-new-measure-of-patient-physician-communication
#14
Scott R Vrana, Dylan T Vrana, Louis A Penner, Susan Eggly, Richard B Slatcher, Nao Hagiwara
RATIONALE: Patient-physician communication plays an essential role in a variety of patient outcomes; however, it is often difficult to operationalize positive patient-physician communication objectively, and the existing evaluation tools are generally time-consuming. OBJECTIVE: This study proposes semantic similarity of the patient's and physician's language in a medical interaction as a measure of patient-physician communication. Latent semantic analysis (LSA), a mathematical method for modeling semantic meaning, was employed to assess similarity in language during clinical interactions between physicians and patients...
December 18, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29260015/evolution-into-moyamoya-disease-in-an-infant-with-internal-carotid-artery-aneurysms
#15
Ryosuke Tanaka, Satoru Takahashi, Satomi Okano, Akie Okayama, Nao Suzuki, Shigeo Kure, Hiroshi Azuma
Introduction: Moyamoya disease (MMD) is characterized by progressive stenosis and occlusion in the terminal portion of both internal carotid arteries (ICAs) and the formation of an abnormal vascular network. Because of the fragile structure of the collateral vessels, MMD is frequently accompanied by intracranial aneurysms that are mainly located within the abnormal basal network or the circle of Willis. However, the association between MMD and aneurysms of the ICAs has never been reported previously...
March 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29259480/efficacy-of-the-endometrial-receptivity-array-for-repeated-implantation-failure-in-japan-a-retrospective-two-centers-study
#16
Tomoko Hashimoto, Masae Koizumi, Masakazu Doshida, Mayumi Toya, Eri Sagara, Nao Oka, Yukiko Nakajo, Nobuya Aono, Hideki Igarashi, Koichi Kyono
Aim: This study aimed to assess the efficacy of the endometrial receptivity array (ERA) as a diagnostic tool and the impact of personalized embryo transfer (pET) for the treatment of patients with recurrent implantation failure (RIF) in Japan. Methods: Fifty patients with a history of RIF with frozen-thawed blastocyst transfers were recruited from July, 2015 to April, 2016. Endometrial sampling for the ERA and histological dating and a pET according to the ERA were performed...
July 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29259386/endoscopic-submucosal-dissection-in-a-patient-with-esophageal-adenoid-cystic-carcinoma
#17
Kenichi Yoshikawa, Akiyoshi Kinoshita, Yuki Hirose, Keiko Shibata, Takafumi Akasu, Noriko Hagiwara, Takeharu Yokota, Nami Imai, Akira Iwaku, Go Kobayashi, Hirohiko Kobayashi, Nao Fushiya, Hiroyuki Kijima, Kazuhiko Koike, Haruka Kaneyama, Keiichi Ikeda, Masayuki Saruta
We report the first use of endoscopic submucosal dissection (ESD) for the treatment of a patient with adenoid cystic carcinoma of the esophagus (EACC). An 82-year-old woman visited our hospital for evaluation of an esophageal submucosal tumor. Endoscopic examination showed a submucosal tumor in the middle third of the esophagus. The lesion partially stained with Lugol's solution, and narrow band imaging with magnification showed intrapapillary capillary loops with mild dilatation and a divergence of caliber in the center of the lesion...
December 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29258972/characteristics-of-articles-about-human-papillomavirus-vaccination-in-japanese-newspapers-time-series-analysis-study
#18
Nao Ueda, Ryoki Yokouchi, Taro Onoda, Atsushi Ogihara
BACKGROUND: Media coverage and reports have a major influence on individual vaccination and other health-related activities. People use the media to seek information and knowledge on health-related behaviors. They obtain health-related information from media such as television and newspapers, and they trust such information. While several studies have examined the relation between media coverage and individual health, there is a lack of studies that have analyzed media reports of health information...
December 19, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29251800/challenging-a-15-year-old-claim-the-nao-index-as-a-predictor-of-spring-migration-phenology-of-birds
#19
Birgen Haest, Ommo Hüppop, Franz Bairlein
Many migrant bird species that breed in the Northern Hemisphere show advancement in spring arrival dates. The North Atlantic Oscillation (NAO) index is one of the climatic variables that have been most often investigated and shown to be correlated with these changes in spring arrival. Although the NAO is often claimed to be a good predictor or even to have a marked effect on interannual changes in spring migration phenology of Northern Hemisphere breeding birds, the results on relations between spring migration phenology and NAO show a large variety, ranging from no, over weak, to a strong association...
December 18, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29249777/-relationship-between-exercise-adherence-and-personality-characteristics-in-persons-experienced-in-the-medical-fitness-program
#20
Yuko Yamashita, Nao Seki, Kimie Umeda, Naohito Tanabe, Kunihiko Shinoda, Isamu Konishi, Akiyoshi Sekiya, Akiko Sekii, Tamaki Ohta
Objective We examined effective exercise adherence support methods for persons experienced in the Medical Fitness (MF) program to clarify the relation of personality traits with exercise adherence and the factors that improve exercise adherence.Methods Subjects were 283 adults who had registered as members in the MF program at an affiliate of Hospital A. We implemented an anonymous self-administered questionnaire by postal mail. Using the Japanese version of the Ten Item Personality Inventory (which contains 10 items that measure the Big Five personality traits), we evaluated the following characteristics: "Extraversion", "Agreeableness", "Conscientiousness", "Neuroticism", and "Openness"...
2017: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
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