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https://www.readbyqxmd.com/read/29771235/bordetella-pertussis-population-dynamics-and-phylogeny-in-japan-after-adoption-of-acellular-pertussis-vaccines
#1
Aldert Zomer, Nao Otsuka, Yukihiro Hiramatsu, Kazunari Kamachi, Naoko Nishimura, Takao Ozaki, Jan Poolman, Jeroen Geurtsen
Bordetella pertussis, the causative agent of whooping cough, has experienced a resurgence in the past 15 years, despite the existence of both whole-cell and acellular vaccines. Here, we performed whole genome sequencing analysis of 149 clinical strains, provided by the National Institute of Infectious Diseases (NIID), Japan, isolated in 1982-2014, after Japan became the first country to adopt acellular vaccines against B. pertussis. Additionally, we sequenced 39 strains provided by the Konan Kosei Hospital in Aichi prefecture, Japan, isolated in 2008-2013...
May 17, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29766599/randomized-clinical-trial-to-evaluate-the-effectiveness-of-enrofloxacin-as-a-second-line-antibiotic-for-treatment-of-acute-escherichia-coli-mastitis
#2
Yasunori Shinozuka, Kazuhiro Kawai, Akira Takeda, Michiaki Yamada, Fumi Kayasaki, Nao Kondo, Yoshiko Sasaki, Nahoko Kanai, Takuma Mukai, Naoki Sawaguchi, Masaya Higuchi, Haruka Kondo, Kouki Sugimoto, Akane Yasuda, Aiko Watanabe
The objective of the present study was to evaluate the effectiveness of enrofloxacin (ERFX) as a second-line antibiotic for treatment of acute Escherichia coli (E. coli) mastitis. Forty-two cows with naturally occurring acute E. coli mastitis were enrolled. On the first day of treatment (day 0), empirically selected antibiotics (oxytetracycline: n = 32, kanamycin: n = 10) were administered. Although systemic signs improved in 10 cows (first-line group), the signs remained unchanged or worsened in 32 cows on day 1, including two cows that were found dead...
May 16, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29758561/surgical-outcome-and-hepatic-regeneration-after-hepatic-resection-for-hepatocellular-carcinoma-in-elderly-patients
#3
Yoshihiro Inoue, Ryo Tanaka, Kensuke Fujii, Nao Kawaguchi, Masatsugu Ishii, Shinsuke Masubuchi, Masashi Yamamoto, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
INTRODUCTION: The rising proportion of elderly patients (aged 80 yearsor above) in our population means that more elderly patients are undergoing hepatectomy. METHODS: Five-hundred and thirty patients who underwent hepatectomy for hepatocellular carcinoma (HCC) were retrospectively analyzed with respect to their preoperative status and perioperative results, including remnant liver regeneration. The remnant liver volume was postoperatively measured with multidetector CT on postoperative day 7 and 1, 2, 5, and 12 months after surgery...
May 14, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29758281/purinergic-molecules-in-the-epidermis
#4
Youichi Ogawa, Manao Kinoshita, Nao Mizumura, Shiho Miyazaki, Rui Aoki, Akira Momosawa, Shinji Shimada, Taiho Kambe, Tatsuyoshi Kawamura
No abstract text is available yet for this article.
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29730245/role-of-spyglass-ds-tm-in-the-preoperative-assessment-of-pancreatic-intraductal-papillary-mucinous-neoplasm-involving-the-main-pancreatic-duct
#5
Takao Ohtsuka, Yoshitaka Gotoh, Yohei Nakashima, Yoshifumi Okayama, So Nakamura, Makiko Morita, Mohammed Y F Aly, Vittoria Vanessa D M Velasquez, Yasuhisa Mori, Yoshihiko Sadakari, Kohei Nakata, Yoshihiro Miyasaka, Kousei Ishigami, Nao Fujimori, Naoki Mochidome, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura
BACKGROUND/OBJECTIVES: It is often difficult to determine an adequate resection line during pancreatectomy for intraductal papillary mucinous neoplasm involving the main pancreatic duct during partial pancreatectomy. The aim of this study was to evaluate the usefulness of improved peroral pancreatoscopy using SpyGlass-DStm in the preoperative assessment of intraductal papillary mucinous neoplasm involving the main pancreatic duct. METHODS: We collected and retrospectively analyzed clinicopathological data from seven consecutive patients who underwent preoperative assessment of intraductal papillary mucinous neoplasm involving the main duct using SpyGlass-DStm ...
April 30, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29724701/experiences-of-a-motivational-interview-delivered-by-a-robot-qualitative-study
#6
Joana Galvão Gomes da Silva, David J Kavanagh, Tony Belpaeme, Lloyd Taylor, Konna Beeson, Jackie Andrade
BACKGROUND: Motivational interviewing is an effective intervention for supporting behavior change but traditionally depends on face-to-face dialogue with a human counselor. This study addressed a key challenge for the goal of developing social robotic motivational interviewers: creating an interview protocol, within the constraints of current artificial intelligence, which participants will find engaging and helpful. OBJECTIVE: The aim of this study was to explore participants' qualitative experiences of a motivational interview delivered by a social robot, including their evaluation of usability of the robot during the interaction and its impact on their motivation...
May 3, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29720971/oligomannose-rich-membranes-of-dying-intestinal-epithelial-cells-promote-host-colonization-by-adherent-invasive-e-coli
#7
Tetiana Dumych, Nao Yamakawa, Adeline Sivignon, Estelle Garenaux, Stefania Robakiewicz, Bernadette Coddeville, Antonino Bongiovanni, Fabrice Bray, Nicolas Barnich, Sabine Szunerits, Christian Slomianny, Martin Herrmann, Sébastien G Gouin, Alexander D Lutsyk, Luis E Munoz, Frank Lafont, Christian Rolando, Rostyslav Bilyy, Julie M J Bouckaert
A novel mechanism is revealed by which clinical isolates of adherent-invasive Escherichia coli (AIEC) penetrate into the epithelial cell layer, replicate, and establish biofilms in Crohn's disease. AIEC uses the FimH fimbrial adhesin to bind to oligomannose glycans on the surface of host cells. Oligomannose glycans exposed on early apoptotic cells are the preferred binding targets of AIEC, so apoptotic cells serve as potential entry points for bacteria into the epithelial cell layer. Thereafter, the bacteria propagate laterally in the epithelial intercellular spaces...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29720647/a-midline-thalamic-circuit-determines-reactions-to-visual-threat
#8
Lindsey D Salay, Nao Ishiko, Andrew D Huberman
How our internal state is merged with our visual perception of an impending threat to drive an adaptive behavioural response is not known. Mice respond to visual threats by either freezing or seeking shelter. Here we show that nuclei of the ventral midline thalamus (vMT), the xiphoid nucleus (Xi) and nucleus reuniens (Re), represent crucial hubs in the network controlling behavioural responses to visual threats. The Xi projects to the basolateral amygdala to promote saliency-reducing responses to threats, such as freezing, whereas the Re projects to the medial prefrontal cortex (Re→mPFC) to promote saliency-enhancing, even confrontational responses to threats, such as tail rattling...
May 2, 2018: Nature
https://www.readbyqxmd.com/read/29717400/crizotinib-induced-simultaneous-multiple-cardiac-toxicities
#9
Takuya Oyakawa, Nao Muraoka, Kei Iida, Masatoshi Kusuhara, Takahisa Kawamura, Tateaki Naito, Toshiaki Takahashi
Crizotinib is a receptor tyrosine kinase inhibitor that has several targets, including c-ros oncogene 1 and the MET proto-oncogene. Considering its known cardiac toxicity, bradycardia is often investigated following treatment with crizotinib. Our patients had bradycardia, QT prolongation, ventricular rhythm, ventricular fibrillation, and pericarditis simultaneously. The cardiotoxicity of crizotinib can sometimes be simultaneous; thus, intensive observation is needed.
May 2, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29710593/understanding-linkages-between-global-climate-indices-and-terrestrial-water-storage-changes-over-africa-using-grace-products
#10
R O Anyah, E Forootan, J L Awange, M Khaki
Africa, a continent endowed with huge water resources that sustain its agricultural activities is increasingly coming under threat from impacts of climate extremes (droughts and floods), which puts the very precious water resource into jeopardy. Understanding the relationship between climate variability and water storage over the continent, therefore, is paramount in order to inform future water management strategies. This study employs Gravity Recovery And Climate Experiment (GRACE) satellite data and the higher order (fourth order cumulant) statistical independent component analysis (ICA) method to study the relationship between terrestrial water storage (TWS) changes and five global climate-teleconnection indices; El Niño-Southern Oscillation (ENSO), North Atlantic Oscillation (NAO), Madden-Julian Oscillation (MJO), Quasi-Biennial Oscillation (QBO) and the Indian Ocean Dipole (IOD) over Africa for the period 2003-2014...
April 24, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29710578/influence-of-climate-cycles-on-grapevine-domestication-and-ancient-migrations-in-eurasia
#11
Luigi Mariani, Gabriele Cola, David Maghradze, Osvaldo Failla, Franco Zavatti
The objective of this work is to investigate the Holocenic climate cycles that may have influenced the domestication of grapevine in the Subcaucasian area and its subsequent spread in Eurasia. The analysis covered the longitudinal belt ranging from the Iberian Peninsula to Japan, seen as the preferential pathway for the Holocenic spread of grapevine and many other crops in Eurasia. Spectral analysis was considered as the criterion of investigation and the Holocenic cycles were analyzed considering different geochemical and biological proxies, of which seven are directly referred to vine...
April 23, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29709779/exploring-the-effects-of-climatic-variables-on-monthly-precipitation-variation-using-a-continuous-wavelet-based-multiscale-entropy-approach
#12
Kiyoumars Roushangar, Farhad Alizadeh, Jan Adamowski
Understanding precipitation on a regional basis is an important component of water resources planning and management. The present study outlines a methodology based on continuous wavelet transform (CWT) and multiscale entropy (CWME), combined with self-organizing map (SOM) and k-means clustering techniques, to measure and analyze the complexity of precipitation. Historical monthly precipitation data from 1960 to 2010 at 31 rain gauges across Iran were preprocessed by CWT. The multi-resolution CWT approach segregated the major features of the original precipitation series by unfolding the structure of the time series which was often ambiguous...
April 27, 2018: Environmental Research
https://www.readbyqxmd.com/read/29707446/pyoderma-gangrenosum-secondary-to-severe-congenital-neutropenia
#13
Nao Wakabayashi, Mamiko Tosa, Shinichi Anzai, Rei Ogawa
We encountered a case of a man who was diagnosed with severe congenital neutropenia as a child and presented at the age of 45 years with pyoderma gangrenosum (PG) of the lower leg. PG associates with an underlying systemic disease, most commonly inflammatory bowel, rheumatic, or hematological disease or malignancy. However, in many cases, the underlying disease was not known. Surgery can trigger PG. The histopathological features of PG were nonspecific, and diagnosis requires excluding other conditions that have a similar appearance...
March 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29704737/laparoscopic-and-percutaneous-repair-of-a-large-midline-incisional-hernia-extending-to-the-bilateral-subcostal-region-a-case-report
#14
Shingo Tsujinaka, Yukio Nakabayashi, Nao Kakizawa, Rina Kikugawa, Nobuyuki Toyama, Toshiki Rikiyama
INTRODUCTION: Optimal surgery for a midline incisional hernia extending to the subcostal region remains unclear. We report successful hybrid laparoscopic and percutaneous repair for such a complex incisional hernia. PRESENTATION OF CASE: An 85-year-old woman developed a symptomatic incisional hernia after open cholecystectomy. Computed tomography revealed a 14 × 10 cm fascial defect. Four trocars were placed under general anesthesia. Percutaneous defect closure was performed using multiple non-absorbable monofilament threads, i...
April 21, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29696196/remission-induction-by-raising-the-dose-of-remicade-in-ra-rrrr-study-rationale-and-study-protocol-for-a-randomized-controlled-trial-comparing-for-sustained-clinical-remission-after-discontinuation-of-infliximab-in-patients-with-rheumatoid-arthritis
#15
Koji Oba, Nao Horie, Norihiro Sato, Kazuyoshi Saito, Tsutomu Takeuchi, Tsuneyo Mimori, Nobuyuki Miyasaka, Takao Koike, Yoshiya Tanaka
Infliximab, an inhibitor of TNF-α, is one of the most widely used biological disease-modifying antirheumatic drugs. Recent studies indicated that baseline serum TNF-α could be considered as a key indicator for optimal dosing of infliximab for RA treatment to achieve the clinical response and its sustained remission. The Remission induction by Raising the dose of Remicade in RA (RRRR) study is an open-label, parallel group, multicenter randomized controlled trial to compare the proportions of clinical remission based on the simplified disease activity index (SDAI) after 1 year of treatment and its sustained remission rate after another 1 year between the investigational treatment strategy (for which the dose of infliximab was chosen based on the baseline serum TNF) and the standard strategy of 3 mg/kg per 8 weeks of infliximab administration in infliximab-naïve patients with RA showing an inadequate response to MTX...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29694780/combination-of-amorphous-silk-fiber-spinning-and-post-spinning-crystallization-for-tough-regenerated-silk-fibers
#16
Kenjiro Yazawa, Ali D Malay, Nao Ifuku, Takaoki Ishii, Hiroyasu Masunaga, Takaaki Hikima, Keiji Numata
An artificial spinning system using regenerated silk fibroin solutions is adopted to produce high-performance silk fibers. In previous studies, alcohol-based agents, such as methanol or ethanol, were used to coagulate silk dope solutions, producing silk fiber with poor mechanical properties compared with those of native silk fibers. The alcohol-based coagulation agents induce rapid -sheet crystallization of the silk molecules, which inhibits subsequent alignment of the -sheet crystals. Here, we induce gradual -sheet formation to afford adequate -sheet alignment similar to that of native silk fiber...
April 25, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29693102/multistep-thermal-decomposition-of-granular-sodium-perborate-tetrahydrate-a-kinetic-approach-to-complex-reactions-in-solid-gas-systems
#17
Nobuyoshi Koga, Nao Kameno, Yoji Tsuboi, Takayuki Fujiwara, Masayoshi Nakano, Kazuyuki Nishikawa, Akiko Iwasaki Murata
This article demonstrates a kinetic approach to partially overlapping multistep chemical reactions in solid-gas systems as exemplified by the thermal decomposition of granular sodium perborate tetrahydrate. This reaction proceeds via successive thermal dehydration and decomposition occurring at different temperatures to form sodium metaborate. Each reaction process comprises several kinetic steps originating from different physicochemical and physico-geometric phenomena. The partially overlapping multistep processes were characterized using available thermoanalytical techniques and microscopic observations...
April 25, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29692679/clinical-outcomes-of-assisted-reproductive-technology-treatment-by-using-a-self-injection-of-recombinant-human-chorionic-gonadotropin-as-the-final-maturation-trigger
#18
Koji Nakagawa, Midori Oba, Kaori Ehara, Nozomi Ishigaki, Nao Ino, Akiko Itakura, Ryo Tsutsumi, Katsuki Nakao, Yuko Ojiro, Rikikazu Sugiyama
Purpose: To evaluate the efficacy and safety of self-injections of the prefilled recombinant human chorionic gonadotropin (r-hCG) in a syringe in assisted reproductive technology (ART) treatment for the maturation trigger (MT), as compared to self-injections of conventional hCG and intranasal administration of gonadotropin-releasing hormone agonist (GnRH-a). Methods: Between January and April, 2017, 396 patients who underwent oocyte retrieval were recruited. Of these, 396 patients were classified into three groups, according to the types of MT: (1) the urinary human chorionic gonadotropin (u-hCG) group that consisted of patients who had a self-injection of u-hCG (n = 127); (2) the GnRH-a group that received nasal administration of GnRH-a (n = 159); and (3) the r-hCG group that had a self-injection of r-hCG (n = 110)...
April 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29688181/saline-induced-pd-pa-ratio-predicts-functional-significance-of-coronary-stenosis-assessed-using-fractional-flow-reserve
#19
Yoshiharu Fujimori, Tomoko Baba, Kyohei Yamazaki, Satoshi Hashimoto, Yasushi Yamanaka, Kenichiro Ebisuda, Kazuto Kurihara, Naoki Koike, Nao Takeuchi, Shigeru Nishiyama, Yuya Terasawa, Tadamasa Wakabayashi, Taku Imai
AIMS: Fractional flow reserve (FFR), assessed using distal coronary pressure/aortic pressure (Pd)/(Pa) ratio, functionally evaluates coronary stenosis. An assessment method without vasodilators would be helpful. A single intracoronary bolus of saline decreases Pd because of the speculated low-viscosity effect. We hypothesized that saline-induced Pd/Pa ratio (SPR) could functionally evaluate coronary stenosis. This study aimed to test the accuracy and utility of SPR for predicting FFR ≤0...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29687938/trait-and-state-biomarkers-for-psychiatric-disorders-importance-of-infrastructure-to-bridge-the-gap-between-basic-and-clinical-research-and-industry
#20
Yukiko Y Lema, Nao J Gamo, Kun Yang, Koko Ishizuka
To further improve clinical activities in psychiatry by early diagnosis and early intervention with novel mechanism-guided treatments, there is a great need for biomarkers that reflect "trait" and "state" in major mental disorders. Stable trait biomarkers would allow early diagnosis, prognosis, and hopefully early intervention in these disorders, while dynamic state markers that reflect symptomatic changes would help to develop treatments that target these molecular mechanisms. However, in the search for such biomarkers, and eventually translating them to the clinic and industry, challenges currently exist at multiple levels, from basic scientific understanding, patient sample collection, and sample and data management, to bridging the gap between basic and clinical research and industry...
April 24, 2018: Psychiatry and Clinical Neurosciences
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