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https://www.readbyqxmd.com/read/28809156/the-length-of-poly-c-stretch-in-the-bordetella-pertussis-pfim3-promoter-determines-the-vag-or-vrg-function-of-the-fim3-gene
#1
Nao Otsuka, Nicole Guiso, Valérie Bouchez
Bordetella pertussis, a human pathogenic bacterium, produces either one or two types of serologically distinct fimbriae, Fim2 and Fim3, as virulence factors. The expression of fim2 and fim3 is regulated by the BvgAS two-component system and the length of poly(C) stretches in Pfim promoters. In the Bvg+ phase, B. pertussis virulence-activated genes (vags) are up-regulated and virulence-repressed genes (vrgs) are down-regulated. Previous studies have shown that fim2 is a vag, but there is no consensus on fim3 regulation...
August 15, 2017: Microbiology
https://www.readbyqxmd.com/read/28806906/age-associated-mrna-expression-changes-in-bovine-endometrial-cells-in-vitro
#2
Nao Tanikawa, Ayaka Ohtsu, Ryouka Kawahara-Miki, Koji Kimura, Shuichi Matsuyama, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
BACKGROUND: Endometrial cells secrete various cytokines and the dysfunction of endometrial cells may directly lead to infertility. Interferon tau (IFNT) secreted by trophoblast cells, a well-known pregnancy recognition signal in ruminants, acts on the uterus to prepare for pregnancy. Aging causes cellular and organ dysfunction, and advanced maternal age is associated with reduced fertility. However, few studies have investigated age-dependent changes in the uterus. METHODS: Using next generation sequencing and real-time PCR, we examined mRNA expression in bovine endometrial cells in vitro obtained from young (mean 45...
August 14, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28797767/clinical-and-radiological-features-of-posterior-reversible-encephalopathy-syndrome-in-patients-with-pre-eclampsia-and-eclampsia
#3
X Y Dong, C B Bai, J F Nao
AIM: To analyse and summarise clinical and radiological features among patients with posterior reversible encephalopathy syndrome (PRES), to assess related factors with eclampsia and pre-eclampsia, and to compare the different factors between cytotoxic and vasogenic oedema among PRES patients. MATERIALS AND METHODS: The clinical and radiological findings of 237 pre-eclamptic or eclamptic patients with neurological symptoms were evaluated retrospectively. Multiple logistic regression analyses were performed to compare the differences among these parameters...
August 7, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28793120/functional-health-literacy-and-adherence-to-the-medication-in-older-adults-integrative-review
#4
Nidia Farias Fernandes Martins, Daiane Porto Gautério Abreu, Bárbara Tarouco da Silva, Deisa Salyse Dos Reis Cabral Semedo, Marlene Teda Pelzer, Fabiana Souza Ienczak
Objective: to characterize the national and international scientific production on the relationship of Functional Health Literacy and the adherence to the medication in older adults. Method: integrative review of literature, searching the following online databases: Scientific Electronic Library Online (SCIELO); Latin American and Caribbean Health Sciences Literature (LILACS); Medical Literature Analysis and Retrieval System Online (MEDLINE); and Cumulative Index to Nursing & Allied Health Literature (CINAHL), in June 2016...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28793119/evaluation-of-the-safety-of-hospitalized-older-adults-as-for-the-risk-of-falls
#5
Nathalia de Araújo Sarges, Maria Izabel Penha de Oliveira Santos, Emanuele Cordeiro Chaves
Objective: To evaluate the safety of hospitalized older adults as for the risk of falls according to the parameters of the Morse Fall Scale. Method: Epidemiological, cross-sectional, prospective and descriptive study with n=75. Results: Average age of 71.3 years (SD±8.2); 58.7% male; 44% with low educational level; 38.7% hospitalized for cardiovascular diseases; average hospitalization of 10 days (SD±9.38); 78.7% with comorbidities; 61.3% with the calf circumference ≥ 31 cm; 62...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28793099/factors-associated-with-the-functional-capacity-of-older-adults-with-leprosy
#6
Paula Sacha Frota Nogueira, Marilia Braga Marques, Janaina Fonseca Victor Coutinho, Juliana Cunha Maia, Maria Josefina da Silva, Escolástica Rejane Ferreira Moura
Objective: to investigate the association between socio-demographic and clinical factors and the functional capacity of older adults with leprosy. Method: cross-sectional analytical study conducted in Fortaleza, Ceará, Brazil, with 77 older adult patients with leprosy in a referral service, through interview, medical records and application of the Katz Index and the Lawton and Brody Scale. Results: the mean age was 68.23 years, with prevalence of men, in stable union/married, with mean monthly family income of 2...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28793095/vulnerability-of-caregivers-of-the-elderly-with-dementia-a-cross-sectional-descriptive-study
#7
Bruna Silva Leite, Alessandra Conceição Leite Funchal Camacho, Fabiana Lopes Joaquim, Jonas Lírio Gurgel, Thiago Rodrigues Lima, Raquel Santos de Queiroz
Objective: to evaluate the sociodemographic and clinical profile of the caregivers and its relation with the overburden from the care of the elderly with dementia. Method: a cross-sectional descriptive study; the sample was non-probabilistic, developed with caregivers of elderly people with dementia. The field of investigation was the Health Care Center of the Elderly and their Caregivers (CASIC), in the city of Niterói, Rio de Janeiro, Brazil. Data collection took place from February to June 2016, with the following instruments: a sociodemographic questionnaire and Zarit scale...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28793046/influence-of-the-tilt-angle-of-percutaneous-aortic-prosthesis-on-velocity-and-shear-stress-fields
#8
Bruno Alvares de Azevedo Gomes, Gabriel Cordeiro Camargo, Jorge Roberto Lopes Dos Santos, Luis Fernando Alzuguir Azevedo, Ângela Ourivio Nieckele, Aristarco Gonçalves Siqueira-Filho, Glaucia Maria Moraes de Oliveira
Background: Due to the nature of the percutaneous prosthesis deployment process, a variation in its final position is expected. Prosthetic valve placement will define the spatial location of its effective orifice in relation to the aortic annulus. The blood flow pattern in the ascending aorta is related to the aortic remodeling process, and depends on the spatial location of the effective orifice. The hemodynamic effect of small variations in the angle of inclination of the effective orifice has not been studied in detail...
August 7, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28793044/reproducibility-and-reliability-of-qtc-and-qtcd-measurements-and-their-relationships-with-left-ventricular-hypertrophy-in-hemodialysis-patients
#9
Maria Angélica Gonçalves Alonso, Valentine de Almeida Costa de Castro Lima, Maria Angela Magalhães de Queiroz Carreira, Jocemir Ronaldo Lugon
Background: Left ventricular hypertrophy (LVH) is very common in hemodialysis patients and an independent risk factor for mortality in this population. The myocardial remodeling underlying the LVH can affect ventricular repolarization causing abnormalities in QT interval. Objective: to evaluate the reproducibility and reliability of measurements of corrected QT interval (QTc) and its dispersion (QTcd) and correlate these parameters with LVH in hemodialysis patients...
August 7, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28790218/-an-extracranial-aneurysm-in-the-distal-posterior-inferior-cerebellar-artery-located-at-the-tonsillomedullary-segment-case-report-and-review-of-the-literature
#10
Nao Shimooka, Shigenori Taketsuna, Shiromaru Ishida, Kensaku Senda, Masato Kawai
We report a rare case of subarachnoid hemorrhage(SAH)due to ruptured extracranial aneurysm originating at the caudal loop of the left posterior inferior cerebellar artery(PICA). A 50-year-old woman presented with severe headache and mild consciousness disturbance. Computed tomography(CT)revealed SAH and intraventricular hemorrhage. Vertebral angiography showed an extracranial aneurysm located on the tonsillomedullary segment of the left PICA. During the surgery, no vessel branches were confirmed near the aneurysm, and the aneurysm was successfully clipped through suboccipital craniotomy with C1 laminectomy...
August 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28782575/toxicological-evaluation-of-neoagarooligosaccharides-prepared-by-enzymatic-hydrolysis-of-agar
#11
Sun Joo Hong, Je-Hyeon Lee, Eun Joo Kim, Hea Jung Yang, Jae-Seon Park, Soon-Kwang Hong
Agar, a heterogeneous polymer of galactose, is the main component of the cell wall of marine red algae. It is well established as a safe, non-digestible carbohydrate in Oriental countries. Although neoagarooligosaccharides (NAOs) prepared by the hydrolysis of agar by β-agarase have been reported to exert various biological activities, the safety of these compounds has not been reported to date. For safety evaluation, NAOs containing mainly neoagarotetraose and neoagarohexaose were prepared from agar by enzymatic hydrolysis using β-agarase DagA from Streptomyces coelicolor...
August 3, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28781839/ileum-preserving-expanded-jejunectomy-and-pancreaticoduodenectomy-with-combined-resection-of-the-superior-mesenteric-artery-for-huge-retroperitoneal-solitary-fibrous-tumor
#12
Akinori Egashira, Yasuharu Ikeda, Masaru Morita, Ken-Ichi Taguchi, Nao Kinjyo, Eiji Tsujita, Kazuhito Minami, Manabu Yamamoto, Yasushi Toh
We encountered a patient with a large retroperitoneal solitary fibrous tumor, in whom we could preserve approximately 150 cm of the ileum even after pancreaticoduodenectomy combined with resection of the superior mesenteric artery, thus preventing short bowel syndrome.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28774237/ulnar-neuropathy-due-to-volar-ulnar-displacement-of-the-flexor-tendons-after-open-carpal-tunnel-release-case-report
#13
Katsuhisa Tanabe, Nao Miyamoto
Ulnar nerve neuropathy is a rare complication following the carpal tunnel release. Above all, compression neuropathy is much rare. We report an acute ulnar nerve neuropathy following open carpal tunnel release due to the volar and ulnar displacement of the flexor tendons from the carpal tunnel and review the literature.
September 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28769012/in-vitro-p-glycoprotein-mediated-transport-of-tadalafil-a-comparison-with-sildenafil
#14
Hiroki Higashi, Nao Watanabe, Rika Tamura, Masato Taguchi
Tadalafil and sildenafil are selective inhibitors of phosphodiesterase type 5, showing marked pharmacokinetic variability in patients with pulmonary arterial hypertension. It has been reported that sildenafil is a substrate for P-glycoprotein (P-gp), but whether tadalafil is a substrate for P-gp remains to be determined. The objective of the present study was to elucidate whether tadalafil is a substrate for P-gp. Transcellular transport of sildenafil and tadalafil (5 µM each) was examined using renal epithelial LLC-PK1 and P-gp-expressing LLC-GA5-COL150 cell monolayers...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28768664/preventative-effects-of-a-hif-inhibitor-17-dmag-on-partial-bladder-outlet-obstruction-induced-bladder-dysfunction
#15
Nao Iguchi, M İrfan Dönmez, Anna P Malykhina, Alonso Carrasco, Duncan T Wilcox
Posterior urethral valves are the most common cause of partial bladder outlet obstruction (PBOO) in the pediatric population. Pathological changes in the bladder developed during PBOO are responsible for long-lasting voiding dysfunction in this population despite early surgical interventions. Increasing evidence showed PBOO induces an upregulation of Hypoxia inducible factors (HIFs) and their transcriptional target genes, and they play a role in pathophysiological changes in the obstructed bladders. We hypothesized that blocking HIF pathways can prevent PBOO-induced bladder dysfunction...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28767923/surgical-correction-of-ectopic-penis-and-scrotum-associated-with-bilateral-orchidopexy
#16
Daniel Santos Rocha Sobral, Helder Damásio da Silva, Eulálio Damázio
Ectopic penis is usually associated with penoscrotal transposition, and it is rarely observed in isolation. We report a surgical approach for an extremely rare case. A 10-year-old male patient with bilateral cryptorchidism and ectopic penis and scrotum in perineal area, with no penoscrotal transposition, representing an association not yet described in literature. A previous orchiopexy failed due to ectopic scrotum. By means of an inverted Y incision, the penis was mobilized and a perineal skin flap in form of a testicular sac was prepared...
April 2017: Einstein
https://www.readbyqxmd.com/read/28767921/hospitalization-costs-of-severe-bacterial-pneumonia-in-children-comparative-analysis-considering-different-costing-methods
#17
Sheila Elke Araujo Nunes, Ruth Minamisava, Maria Aparecida da Silva Vieira, Alexander Itria, Vicente Porfirio Pessoa, Ana Lúcia Sampaio Sgambatti de Andrade, Cristiana Maria Toscano
Objective: To determine and compare hospitalization costs of bacterial community-acquired pneumonia cases via different costing methods under the Brazilian Public Unified Health System perspective. Methods: Cost-of-illness study based on primary data collected from a sample of 59 children aged between 28 days and 35 months and hospitalized due to bacterial pneumonia. Direct medical and non-medical costs were considered and three costing methods employed: micro-costing based on medical record review, micro-costing based on therapeutic guidelines and gross-costing based on the Brazilian Public Unified Health System reimbursement rates...
April 2017: Einstein
https://www.readbyqxmd.com/read/28767917/action-of-vanillin-vanilla-planifolia-on-the-morphology-of-tibialis-anterior-and-soleus-muscles-after-nerve-injury
#18
Ana Luiza Peretti, Juliana Sobral Antunes, Keli Lovison, Regina Inês Kunz, Lidyane Regina Gomes Castor, Rose Meire Costa Brancalhão, Gladson Ricardo Flor Bertolini, Lucinéia de Fátima Chasko Ribeiro
Objective: To evaluate the action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after peripheral nerve injury. Methods: Wistar rats were divided into four groups, with seven animals each: Control Group, Vanillin Group, Injury Group, and Injury + Vanillin Group. The Injury Group and the Injury + Vanillin Group animals were submitted to nerve injury by compression of the sciatic nerve; the Vanillin Group and Injury + Vanillin Group, were treated daily with oral doses of vanillin (150mg/kg) from the 3rd to the 21st day after induction of nerve injury...
April 2017: Einstein
https://www.readbyqxmd.com/read/28767916/transection-of-the-hepatic-parenchyma-associated-or-not-with-the-contralateral-portal-vein-branch-ligature-and-its-effect-in-liver-regeneration
#19
Henrique de Aguiar Wiederkehr, Julio Cesar Wiederkehr, Luiz Martins Collaço, Eros Luiz de Sousa, Paolo Salvalaggio, Caroline Aragão de Carvalho, Barbara de Aguiar Wiederkehr, Camila Aparecida Moraes Marques, Francielle França da Rosa, Felipe de Negreiros Nanni, Taíse Fuchs
Objective: To analyze the influence of portal vein ligation in hepatic regeneration by immunohistochemical criteria. Methods: Ten pigs divided into two groups of five animals underwent hepatectomy in two stages, and the groups were differentiated by ligation or not of the left portal vein tributary, which is responsible for vascularization of the left lateral and medial lobes of the pig liver. Five days after the procedure, the animals underwent liver biopsies for further analysis of histological and immunohistochemical with marker Ki67...
April 2017: Einstein
https://www.readbyqxmd.com/read/28767914/comparison-of-enterovirus-detection-in-cerebrospinal-fluid-with-bacterial-meningitis-score-in-children
#20
Frederico Ribeiro Pires, Andréia Christine Bonotto Farias Franco, Alfredo Elias Gilio, Eduardo Juan Troster
Objective: To measure the role of enterovirus detection in cerebrospinal fluid compared with the Bacterial Meningitis Score in children with meningitis. Methods: A retrospective cohort based on analysis of medical records of pediatric patients diagnosed as meningitis, seen at a private and tertiary hospital in São Paulo, Brazil, between 2011 and 2014. Excluded were patients with critical illness, purpura, ventricular shunt or recent neurosurgery, immunosuppression, concomitant bacterial infection requiring parenteral antibiotic therapy, and those who received antibiotics 72 hours before lumbar puncture...
April 2017: Einstein
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