keyword
https://read.qxmd.com/read/38544152/ef-net-mental-state-recognition-by-analyzing-multimodal-eeg-fnirs-via-cnn
#21
JOURNAL ARTICLE
Aniqa Arif, Yihe Wang, Rui Yin, Xiang Zhang, Ahmed Helmy
Analysis of brain signals is essential to the study of mental states and various neurological conditions. The two most prevalent noninvasive signals for measuring brain activities are electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS). EEG, characterized by its higher sampling frequency, captures more temporal features, while fNIRS, with a greater number of channels, provides richer spatial information. Although a few previous studies have explored the use of multimodal deep-learning models to analyze brain activity for both EEG and fNIRS, subject-independent training-testing split analysis remains underexplored...
March 15, 2024: Sensors
https://read.qxmd.com/read/38543886/herpes-zoster-and-cardiovascular-disease-exploring-associations-and-preventive-measures-through-vaccination
#22
REVIEW
Minako Yamaoka-Tojo, Taiki Tojo
Herpes zoster, induced by the reactivation of the varicella-zoster virus (VZV), is a unilaterally distributed vesicular rash that can cause multiple complications. VZV not only causes neurological problems, including postherpetic neuralgia and ocular zoster, but also causes inflammatory vasculopathy and increases the incidence of hemorrhagic or ischemic complications. Therefore, understanding the association between the development of herpes zoster and the subsequent occurrence of acute stroke or cardiovascular diseases, including myocardial infarction and heart failure, is of great interest...
February 28, 2024: Vaccines
https://read.qxmd.com/read/38542782/functional-and-therapeutic-potential-of-cynara-scolymus-in-health-benefits
#23
REVIEW
Chiara Porro, Tarek Benameur, Antonia Cianciulli, Mirco Vacca, Margherita Chiarini, Maria De Angelis, Maria Antonietta Panaro
Dietary supplements enriched with bioactive compounds represent a promising approach to influence physiological processes and enhance longevity and overall health. Cynara cardunculus var. scolymus serves as a functional food supplement with a high concentration of bioactive compounds, which offers various health-promoting benefits. Several chronic diseases have metabolic, genetic, or inflammatory origins, which are frequently interconnected. Pharmacological treatments, although effective, often result in undesirable side effects...
March 17, 2024: Nutrients
https://read.qxmd.com/read/38542764/the-interplay-between-gut-microbiota-and-cognitive-functioning-in-the-healthy-aging-population-a-systematic-review
#24
REVIEW
Maria Kossowska, Sylwia Olejniczak, Marcelina Karbowiak, Wioletta Mosiej, Dorota Zielińska, Aneta Brzezicka
BACKGROUND: The gut microbiota in healthy older individuals typically show a decrease in beneficial bacteria like Bifidobacterium and Lactobacillus, alongside an increase in pro-inflammatory microbes such as Enterobacteriaceae and Clostridia. These changes contrast with younger and middle-aged individuals and appear to correlate with cognitive status. Although there is extensive research on gut microbiota and cognitive functions in cognitively impaired elderly individuals, its impact on cognitively healthy elderly populations has not been extensively studied...
March 15, 2024: Nutrients
https://read.qxmd.com/read/38542513/interactions-between-gut-microbiota-and-oral-antihyperglycemic-drugs-a-systematic-review
#25
REVIEW
Nicoleta Mihaela Mindrescu, Cristian Guja, Viorel Jinga, Sorina Ispas, Antoanela Curici, Andreea Nelson Twakor, Anca Mihaela Pantea Stoian
The intestinal microbiota refers to the collection of microorganisms that exist in the human gut. It has been said that bacteria influence the development of metabolic diseases, such as diabetes mellitus, as they have roles in immunomodulation, protection against pathogens, blood vessel growth, repairing the intestinal wall, and the development of the neurological system. In this review, we look at the latest research regarding interactions between gut microbiota and oral antihyperglycemic drugs and we present data suggesting that the microbiome may help counteract the reduced glucose tolerance and insulin resistance associated with metabolic disorders...
March 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542311/the-chronic-effects-of-a-single-low-intensity-blast-exposure-on-phosphoproteome-networks-and-cognitive-function-influenced-by-mutant-tau-overexpression
#26
JOURNAL ARTICLE
Marcus Jackson, Shanyan Chen, Thao Thi Nguyen, Heather R Siedhoff, Ashley Balderrama, Amitai Zuckerman, Runting Li, C Michael Greenlief, Gregory Cole, Sally A Frautschy, Jiankun Cui, Zezong Gu
Blast-induced neurotrauma (BINT) is a pressing concern for veterans and civilians exposed to explosive devices. Affected personnel may have increased risk for long-term cognitive decline and developing tauopathies including Alzheimer's disease-related disorders (ADRD) or frontal-temporal dementia (FTD). The goal of this study was to identify the effect of BINT on molecular networks and their modulation by mutant tau in transgenic (Tg) mice overexpressing the human tau P301L mutation (rTg4510) linked to FTD or non-carriers...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542149/pyridoxal-5-phosphate-biosynthesis-by-pyridox-am-ine-5-phosphate-oxidase-species-specific-features
#27
REVIEW
Maribel Rivero, Nerea Novo, Milagros Medina
Enzymes reliant on pyridoxal 5'-phosphate (PLP), the metabolically active form of vitamin B6 , hold significant importance in both biology and medicine. They facilitate various biochemical reactions, particularly in amino acid and neurotransmitter metabolisms. Vitamin B6 is absorbed by organisms in its non-phosphorylated form and phosphorylated within cells via pyridoxal kinase (PLK) and pyridox-(am)-ine 5'-phosphate oxidase (PNPOx). The flavin mononucleotide-dependent PNPOx enzyme converts pyridoxine 5'-phosphate and pyridoxamine 5'-phosphate into PLP...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542121/integration-of-ipsc-derived-microglia-into-brain-organoids-for-neurological-research
#28
REVIEW
Muhammad Asif Mrza, Jitian He, Youwei Wang
The advent of Induced Pluripotent Stem Cells (iPSCs) has revolutionized neuroscience research. This groundbreaking innovation has facilitated the development of three-dimensional (3D) neural organoids, which closely mimicked the intricate structure and diverse functions of the human brain, providing an unprecedented platform for the in-depth study and understanding of neurological phenomena. However, these organoids lack key components of the neural microenvironment, particularly immune cells like microglia, thereby limiting their applicability in neuroinflammation research...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542004/special-issue-spinal-cord-injuries-advances-in-rehabilitation
#29
EDITORIAL
Mohit Arora, Ashley R Craig
Spinal cord injury (SCI) is a severe Kolling Institute, neurological disorder resulting from traumatic injury (such as a motor vehicle crash or fall) or non-traumatic injury associated with disease (such as cancer or infection) that results in impaired voluntary motor control and sensory function, usually leading to lifelong severe disability [...].
March 20, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541802/predictors-of-outcome-after-direct-aspiration-of-basilar-artery-occlusion
#30
JOURNAL ARTICLE
Miroslav Mako, Georgi Krastev, Vladimír Nosáľ, Jozef Haring, Denisa Jakubcová, Martin Daniš, Andrej Klepanec, Ján Haršány, Štefan Sivák, Egon Kurča
Background : Basilar artery occlusion (BAO) is a serious disease with a poor prognosis if left untreated. Endovascular therapy (EVT) is the most effective treatment that is able to reduce mortality and disability. Treatment results are influenced by a wide range of factors that have not been clearly identified. In the present study, direct aspiration was chosen as a first-line treatment. The safety and effectiveness of direct aspiration in BAO were determined, and factors affecting patient outcomes were identified...
March 9, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541112/influence-of-education-cognition-and-physical-disability-on-quality-of-life-of-romanian-patients-with-multiple-sclerosis-a-cohort-study
#31
JOURNAL ARTICLE
Alin Ciubotaru, Emilian Bogdan Ignat, Daniel Alexa, Cristina Grosu, Ioana Păvăleanu, Alina Manole, Alexandra Maștaleru, Maria Magdalena Leon, Daniela Viorelia Matei, Doina Azoicăi
Background and Objectives : objective measures of disability and neurological impairmentare used to search for disease activity and monitor disease evolution in multiple sclerosis (MS). These are sometimes in disagreement with subjective quality-of-life measures. We aimed to establish the relations between the Multiple Sclerosis Quality of Life instrument (MSQOL-54) and objective measures of neurological impairment. Materials and Methods : 107 patients with MS were evaluated with the Single Digit Modalities Test (SDMT) for cognition, Nine Holes Peg Test (9HPT) for upper limb function, 25 Feet Walk Test (25FWT) for gait, and EDSS for global disability in a cohort study...
February 25, 2024: Medicina
https://read.qxmd.com/read/38541009/sexual-functioning-and-sexual-health-in-female-patients-following-stroke-a-scoping-review-with-implications-for-rehabilitation
#32
REVIEW
Desirèe Latella, Alessandro Grimaldi, Rocco Salvatore Calabrò
The impact of stroke on the sexual functioning of female survivors can arise from direct neurological effects or be triggered indirectly through various psychophysiological processes. Although an increasing number of publications exist, the topic of sexuality remains seldom discussed in the stroke literature, even though patients have expressed a need for sexual rehabilitation services. A literature review on sexual functioning in post-stroke females examining existing rehabilitation programs addressing patients' sexuality and exploring the perspectives of nurses and caregivers on sexual issues constitutes a novel approach...
February 29, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540843/polysaccharides-as-protective-agents-against-heavy-metal-toxicity
#33
REVIEW
Lukman Iddrisu, Felix Danso, Kit-Leong Cheong, Zhijia Fang, Saiyi Zhong
Polysaccharides are functional foods or drugs that can be used to alleviate heavy metal poisoning by cadmium, lead, mercury, and arsenic. Industries generate substantial quantities of toxic heavy metal wastes, such as wastewater discharges, paints, electronic waste, batteries, pigments, and plastics, into the environment that pose a risk to human health. Therefore, it is imperative to eliminate accumulated heavy metal ions from the body and the environment. Heavy metal toxicity can lead to decreased energy levels and impair the functioning of vital organs, such as the brain, lungs, kidneys, liver, and blood...
March 11, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38540796/revolutionizing-ischemic-stroke-diagnosis-and-treatment-the-promising-role-of-neurovascular-unit-derived-extracellular-vesicles
#34
REVIEW
Xiangyu Gao, Dan Liu, Kangyi Yue, Zhuoyuan Zhang, Xiaofan Jiang, Peng Luo
Ischemic stroke is a fatal and disabling disease worldwide and imposes a significant burden on society. At present, biological markers that can be conveniently measured in body fluids are lacking for the diagnosis of ischemic stroke, and there are no effective treatment methods to improve neurological function after ischemic stroke. Therefore, new ways of diagnosing and treating ischemic stroke are urgently needed. The neurovascular unit, composed of neurons, astrocytes, microglia, and other components, plays a crucial role in the onset and progression of ischemic stroke...
March 20, 2024: Biomolecules
https://read.qxmd.com/read/38540632/health-related-quality-of-life-and-psychosocial-variables-in-women-with-colorectal-pelvic-floor-dysfunction-a-cross-sectional-study
#35
JOURNAL ARTICLE
Rocío Molina-Barea, Mahmoud Slim, Elena P Calandre
Pelvic floor dysfunction comprises various disorders, including urinary incontinence, fecal incontinence, pelvic organ prolapse, and chronic pelvic pain. This study aimed to evaluate health-related quality of life (HRQoL), anxiety, depression, sleep disturbance, and sexual functioning in women with pelvic floor dysfunction of colorectal etiology compared with control women. Patients were recruited from a specialized colorectal unit and controls were selected from among the patients' friends and relatives. Sociodemographic and clinical data were collected...
March 15, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38540295/advancements-in-spinal-cord-injury-repair-insights-from-dental-derived-stem-cells
#36
REVIEW
Xueying Wen, Wenkai Jiang, Xiaolin Li, Qian Liu, Yuanyuan Kang, Bing Song
Spinal cord injury (SCI), a prevalent and disabling neurological condition, prompts a growing interest in stem cell therapy as a promising avenue for treatment. Dental-derived stem cells, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from the apical papilla (SCAP), dental follicle stem cells (DFSCs), are of interest due to their accessibility, minimally invasive extraction, and robust differentiating capabilities. Research indicates their potential to differentiate into neural cells and promote SCI repair in animal models at both tissue and functional levels...
March 19, 2024: Biomedicines
https://read.qxmd.com/read/38540249/neuroprotective-effects-of-krypton-inhalation-on-photothrombotic-ischemic-stroke
#37
JOURNAL ARTICLE
Viktoriya V Antonova, Denis N Silachev, Egor Y Plotnikov, Irina B Pevzner, Elmira I Yakupova, Mikhail V Pisarev, Ekaterina A Boeva, Zoya I Tsokolaeva, Maxim A Lyubomudrov, Igor V Shumov, Andrey V Grechko, Oleg A Grebenchikov
This is the first in vivo study to investigate the neuroprotective effects of krypton on focal cerebral ischemia. The aim of the study was to analyze the effect of 2 h of inhalation of a krypton-oxygen mixture (Kr 70%/O2 30%) on the recovery of neurological functions and the degree of brain damage in rats after photoinduced ischemic stroke (PIS) and to investigate the possible mechanisms responsible for this neuroprotection. Experiments were performed on male Wistar rats weighing 250-300 g (n = 32). Animals were randomized into four groups...
March 13, 2024: Biomedicines
https://read.qxmd.com/read/38540227/msr405-inhibiting-neuroinflammation-after-spinal-cord-injury-in-rats
#38
JOURNAL ARTICLE
Yu Liu, Yu Xiao, Jimeng Gao, Jiaxin Gao, Ruicheng Li, Zhongquan Qi, Xiaocun Liu
The treatment of spinal cord injury (SCI) is often ineffective. Additionally, SCI-induced inflammation leads to secondary injury. Current anti-inflammatory hydrophilic drugs fail to reach the nerve injury site due to the blood-brain barrier. Here, we synthesized MSR405, a new lipophilic unsaturated fatty acid derivative of Radix Isatidis and investigated its therapeutic effect in SCI model rats. Furthermore, we systematically investigated its structure, toxicity, anti-inflammatory effect, and the underlying mechanism...
March 8, 2024: Biomedicines
https://read.qxmd.com/read/38540226/from-lab-to-life-exploring-cutting-edge-models-for-neurological-and-psychiatric-disorders
#39
EDITORIAL
Masaru Tanaka, László Vécsei
Neuroscience, neurology, and psychiatry are rapidly evolving fields that aim to understand the complex mechanisms underlying brain function and dysfunction, as well as to develop effective interventions for various neurological and psychiatric disorders [...].
March 8, 2024: Biomedicines
https://read.qxmd.com/read/38540093/identification-of-cyfip2-arg87cys-ligands-via-in-silico-and-in-vitro-approaches
#40
JOURNAL ARTICLE
Ísis Venturi Biembengut, Emanuella de Castro Andreassa, Tatiana A C B de Souza
The advancement of next-generation sequencing has enabled the identification of specific mutations associated with early infantile epileptic encephalopathies (EIEEs). In EIEE, epileptic spasms and seizures that occur since early childhood lead to impaired neurological development. The CYFIP2 p.Arg87Cys variant was recently related to EIEE. CYFIP2 participates in the Wave Regulatory Complex (WRC), which is related to the regulation of actin dynamics. The variant residue is at the interface between the CYFIP2 protein and WAVE1 protein inside the WRC...
February 21, 2024: Biomedicines
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