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Functional neurology

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https://www.readbyqxmd.com/read/29054023/charting-the-territory-describing-the-functional-abilities-of-children-with-progressive-neurological-conditions
#1
Sandy K Tatla, Liisa Holsti, Gail Stephanie Andrews, Leanne Feichtinger, Rose Steele, Harold Siden
AIMS: Little is known about the functional abilities of children with progressive genetic, metabolic, or neurological conditions (PNCs). In this study, children with PNCs were followed over a 2-year period to assess their functional abilities over time. Specific aims were to: 1) describe the changes in functional skills and the effects of age for children with PNCs, 2) assess changes in these children's need for caregiver assistance over time, and 3) examine relationships between these children's functional skills and need for caregiver assistance...
October 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29054021/qprtase-modified-n-doped-carbon-quantum-dots-a-fluorescent-bioprobe-for-selective-detection-of-neurotoxin-quinolinic-acid-in-human-serum
#2
Ranjana Singh, Sunayana Kashayap, Vimal Singh, Arvind M Kayastha, Hirdyesh Mishra, Preeti Suman Saxena, Anchal Srivastava, Ranjan K Singh
Highly fluorescent nitrogen doped carbon quantum dots (NCQDs) were synthesized using microwave assisted green method. It was characterized by Transmission Electron Microscopy (TEM), FTIR, UV-Visible absorption and Photoluminiscence (PL) techniques. The NCQDs were immobilized with an enzyme named quinolinate phoshphoribosyl transferase (QPRTase). The NCQDs immobilized by QPRTase was used as a fluorescent bioprobe for the selective detection of endogenous neurotoxin quinolinic acid (QA) whose elevated level in serum is marker of many neurological disorders such as Alzheimer's, Huntington's and HIV associated dementia (HAD) as well as deficiency of vitamin B6...
October 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29053903/galectin-3-an-emerging-biomarker-in-stroke-and-cerebrovascular-diseases
#3
Anand Venkatraman, Shalaka Hardas, Nirav Patel, Navkaranbir Singh Bajaj, Garima Arora, Pankaj Arora
BACKGROUND: The carbohydrate-binding molecule Galectin-3 has garnered significant attention recently as a biomarker for various conditions ranging from cardiac disease to obesity. Though there have been several recent studies investigating its role in stroke and other cerebrovascular diseases, awareness of this emerging biomarker in the wider neurology community is limited. METHODS: We performed a systematic search in PubMed, EMBASE, Scopus, CINAHL, Clinicaltrials...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053789/voodoo-surgery-the-distinct-challenges-of-functional-neuroimaging-in-clinical-neurology
#4
Trevor T-J Chong
No abstract text is available yet for this article.
October 17, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053782/seizure-onset-zone-localization-using-postictal-hypoperfusion-detected-by-arterial-spin-labelling-mri
#5
Ismael Gaxiola-Valdez, Shaily Singh, Tefani Perera, Sherry Sandy, Emmy Li, Paolo Federico
Neurological dysfunction following epileptic seizures is a well-recognized phenomenon. Several potential mechanisms have been suggested to explain postictal dysfunction, with alteration in cerebral blood flow being one possibility. These vascular disturbances may be long lasting and localized to brain areas involved in seizure generation and propagation, as supported by both animal and human studies. Therefore, measuring perfusion changes in the postictal period may help localize the seizure onset zone. Arterial spin labelling is a non-invasive, rapid and reproducible magnetic resonance imaging technique that measures cerebral perfusion...
September 28, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053121/-possibilities-of-cavinton-therapy-regimen-for-infusions-and-cavinton-comforte-in-acute-and-early-recovery-periods-after-ischemic-stroke
#6
L A Belova, V V Mashin, A N Proshin, A N Ovsyannicova, B B Kostishko
AIM: To study the efficacy of a current regimen of treatment with cavinton for infusions and cavinton comforte in patients with ischemic stroke in acute and early recovery periods and to evaluate an impact of treatment on erythrocyte deformity using atomic power microscopy. MATERIAL AND METHODS: One hundred and sixty-four patients with hemispheric ischemic stroke, aged from 30 to 79 years, were randomized into main (n=100) and control (n=64) groups. Patients of the main group received complex treatment (basic therapy and cavinton R for drop infusions (10 intravenously during 10 days) followed by cavinton R comforte in dose 10 mg, 1 tablet 3 times a day during 90 days)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29052972/impaired-intestinal-barrier-function-and-relapsing-digestive-disease-lessons-from-a-porcine-model-of-early-life-stress
#7
REVIEW
A L Ziegler, A T Blikslager
Within this issue of Neurogastroenterology and Motility, an article by Pohl et al highlights new insights from a powerful porcine model of the link between early life adversity and relapsing functional gastrointestinal disorders. Early weaning stress closely mimics the early life psychosocial stressors that have been linked to adult onset gastrointestinal dysfunction. This early weaning model provides reproducible and highly translatable outcomes in young stress-challenged pigs. Due to the convincingly comparable neurological and gastroenterological anatomy and physiology between pigs and human beings, gastrointestinal stress and injury studies utilizing swine models will provide invaluable insights to improve our understanding and treatment of gastrointestinal disease in human beings...
November 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29052709/association-of-prognostic-factors-and-immunosuppressive-treatment-with-long-term-outcomes-in-neurosarcoidosis
#8
Bastien Joubert, Catherine Chapelon-Abric, Lucie Biard, David Saadoun, Sophie Demeret, Didier Dormont, Matthieu Resche-Rigon, Patrice Cacoub
Importance: Prognostic factors are lacking in neurosarcoidosis (NS), and the association of immunosuppressive treatments with outcomes are unclear. Objectives: To identify prognostic factors of and analyze the association of immunosuppressive treatment with relapse of NS. Design, Setting, and Participants: In this retrospective study, a cohort of 234 patients fulfilled the diagnostic criteria for NS in a tertiary referral center in Paris, France, from January 1, 1990, through December 31, 2015...
October 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29052398/-protective-effect-and-mechanism-of-scutellarin-ethyl-ester-on-focal-cerebral-ischemia-induced-by-ligation-of-middle-cerebral-artery-in-rats
#9
Xiao-Jing Ma, Lan Wang, Xiao-Jie Yin, Zhi-Min Wang, Xiao-Qian Liu, Lei-Lei Gong, Liang-Mian Chen, Ri-Xin Liang, Hui-Min Gao
To observe the protective effect of scutellarin ethyl ester on focal cerebral ischemia injury induced by middle cerebral artery occlusion in rats(MCAOR), and explore its mechanism. Totally 84 male SD rats were randomly divided into seven groups: sham-operated group, model group,positive drug group(niomdipine,12 mg•kg⁻¹), Brevisapin tablets group(48 mg•kg⁻¹), and high, middle and low-dose scutellarin ethyl ester groups(100, 50, 25 mg•kg⁻¹). The MCAOR model was prepared by using thread embolism method to observe the neurological function of rats, the area of cerebral infarction was measured with TTC, and the levels of MDA, SOD and NO in serum were detected with semiautomatic biochemistry analyzer...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29052102/changes-in-cerebellar-functional-connectivity-and-autonomic-regulation-in-cancer-patients-treated-with-the-neuro-emotional-technique-for-traumatic-stress-symptoms
#10
Daniel A Monti, Anna Tobia, Marie Stoner, Nancy Wintering, Michael Matthews, Chris J Conklin, Feroze B Mohamed, Inna Chervoneva, Andrew B Newberg
PURPOSE: A growing number of research studies have implicated the cerebellum in emotional processing and regulation, especially with regard to negative emotional memories. However, there currently are no studies showing functional changes in the cerebellum as a result of treatment for traumatic stress symptoms. The Neuro Emotional Technique (NET) is an intervention designed to help improve symptoms related to traumatic stress using an integrative approach that combines emotional, cognitive, and motor processing, with a particular focus on autonomic nervous system regulation...
October 19, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29051745/traumatic-brain-injury-severity-neuropathophysiology-and-clinical-outcome-insights-from-multimodal-neuroimaging
#11
Andrei Irimia, Sheng-Yang Matthew Goh, Adam C Wade, Kavi Patel, Paul M Vespa, John D Van Horn
BACKGROUND: The relationship between the acute clinical presentation of patients with traumatic brain injury (TBI), long-term changes in brain structure prompted by injury and chronic functional outcome is insufficiently understood. In this preliminary study, we investigate how acute Glasgow coma score (GCS) and epileptic seizure occurrence after TBIs are statistically related to functional outcome (as quantified using the Glasgow Outcome Score) and to the extent of cortical thinning observed 6 months after the traumatic event...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29051136/using-google-glass-in-nonsurgical-medical-settings-systematic-review
#12
Bryn Dougherty, Sherif M Badawy
BACKGROUND: Wearable technologies provide users hands-free access to computer functions and are becoming increasingly popular on both the consumer market and in various industries. The medical industry has pioneered research and implementation of head-mounted wearable devices, such as Google Glass. Most of this research has focused on surgical interventions; however, other medical fields have begun to explore the potential of this technology to support both patients and clinicians. OBJECTIVE: Our aim was to systematically evaluate the feasibility, usability, and acceptability of using Google Glass in nonsurgical medical settings and to determine the benefits, limitations, and future directions of its application...
October 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29050398/delineating-sptan1-associated-phenotypes-from-isolated-epilepsy-to-encephalopathy-with-progressive-brain-atrophy
#13
Steffen Syrbe, Frederike L Harms, Elena Parrini, Martino Montomoli, Ulrike Mütze, Katherine L Helbig, Tilman Polster, Beate Albrecht, Ulrich Bernbeck, Ellen van Binsbergen, Saskia Biskup, Lydie Burglen, Jonas Denecke, Bénédicte Heron, Henrike O Heyne, Georg F Hoffmann, Frauke Hornemann, Takeshi Matsushige, Ryuki Matsuura, Mitsuhiro Kato, G Christoph Korenke, Alma Kuechler, Constanze Lämmer, Andreas Merkenschlager, Cyril Mignot, Susanne Ruf, Mitsuko Nakashima, Hirotomo Saitsu, Hannah Stamberger, Tiziana Pisano, Jun Tohyama, Sarah Weckhuysen, Wendy Werckx, Julia Wickert, Francesco Mari, Nienke E Verbeek, Rikke S Møller, Bobby Koeleman, Naomichi Matsumoto, William B Dobyns, Domenica Battaglia, Johannes R Lemke, Kerstin Kutsche, Renzo Guerrini
De novo in-frame deletions and duplications in the SPTAN1 gene, encoding the non-erythrocyte αII spectrin, have been associated with severe West syndrome with hypomyelination and pontocerebellar atrophy. We aimed at comprehensively delineating the phenotypic spectrum associated with SPTAN1 mutations. Using different molecular genetic techniques, we identified 20 patients with a pathogenic or likely pathogenic SPTAN1 variant and reviewed their clinical, genetic and imaging data. SPTAN1 de novo alterations included seven unique missense variants and nine in-frame deletions/duplications of which 12 were novel...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050391/psychogenic-amnesia-syndromes-outcome-and-patterns-of-retrograde-amnesia
#14
Neil A Harrison, Kate Johnston, Federica Corno, Sarah J Casey, Kimberley Friedner, Kate Humphreys, Eli J Jaldow, Mervi Pitkanen, Michael D Kopelman
There are very few case series of patients with acute psychogenic memory loss (also known as dissociative/functional amnesia), and still fewer studies of outcome, or comparisons with neurological memory-disordered patients. Consequently, the literature on psychogenic amnesia is somewhat fragmented and offers little prognostic value for individual patients. In the present study, we reviewed the case records and neuropsychological findings in 53 psychogenic amnesia cases (ratio of 3:1, males:females), in comparison with 21 consecutively recruited neurological memory-disordered patients and 14 healthy control subjects...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050170/-a-chinese-experts-consensus-of-neurophysiological-evaluating-for-microvascular-decompression
#15
(no author information available yet)
With the extensive development of microvascular decompression (MVD), perioperative neurophysiological monitoring technology is also developping rapidly in our country. To promote the standardization of neurophysiological monitoring for MVD in China, the experts consensus was published. This consensus includes five sections: indications, stimulation and recording methods, intraoperative assessment and warning criteria, influencing factors, and clinical application recommendations. Furthermore, recommendations for selection of electrophysiological monitoring and recording requirements were attached...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29050101/-factors-of-hearing-preservation-in-acoustic-neuroma-surgery
#16
H Y Tan, Z Y Wang, H Wu
Over the past 50 years, the focus of acoustic neuroma surgery has shifted from low mortality and tumor resection to retention of neurological function. Hearing preservation is another point in addition to facial nerve function preservation. Hearing preservation rates overall ranged from 2% to 93% in recent studies. Characteristics such as approach, pre-operative neurological function, tumor size, nerve of origin and fundal fluid of the internal auditory canal have been reported as possible influencing factors...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29050006/recent-insights-into-the-biological-functions-of-sestrins-in-health-and-disease
#17
Menglong Wang, Yao Xu, Jianfang Liu, Jing Ye, Wenhui Yuan, Huimin Jiang, Zhen Wang, Hong Jiang, Jun Wan
Sestrins (Sesns) have been identified as a family of highly conserved stress-inducible proteins that are strongly up-regulated by various stresses, including DNA damage, oxidative stress, and hypoxia. The Sesns play protective roles in most physiological and pathological conditions mainly through the regulation of oxidative stress, inflammation, autophagy, endoplasmic reticulum stress, and metabolic homeostasis. In this review, we discussed the possible regulators of Sesns expression, such as p53, forkhead box O, nuclear factor erythroid 2 like 2 (Nrf2), NH (2)-terminal kinase (JNK)/c-Jun pathway and hypoxia-inducible factor-1α (Hif-1α), and the downstream pathways regulated by the Sesns including AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling, mitogen-activated protein kinases (MAPKs) signaling, Nrf2 signaling, NADPH oxidase signaling and transforming growth factor β (TGF-β) signaling in heart diseases, lung diseases, gastrointestinal tract diseases, liver and metabolism diseases, neurological diseases, kidney diseases and immunological diseases...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29049855/intra-arterial-transplantation-of-human-bone-marrow-mesenchymal-stem-cells-hbmmscs-improves-behavioral-deficits-and-alters-gene-expression-in-rodent-stroke-model
#18
Vibhuti, Rehan Khan, Alpana Sharma, Suman Jain, Sujata Mohanty, Kameshwar Prasad
Stroke is a multi-factorial polygenic disease and is a major cause of death and adult disability. Administration of bone marrow stem cells protects ischemic rat brain by facilitating recovery of neurological functions. But the molecular mechanism of stem cells action and their effect on gene expression is not well explored. In this study, we have transplanted 1× 10(6) human bone marrow mesenchymal stem cells (hBMMSCs) in middle cerebral artery occluded (MCAo) adult male Wistar rats through intracarotid artery route at 24 hours after surgery...
October 19, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29049834/percutaneous-left-atrial-unloading-to-prevent-pulmonary-oedema-and-to-facilitate-ventricular-recovery-under-extracorporeal-membrane-oxygenation-therapy
#19
Alexander M Bernhardt, Mathias Hillebrand, Yalin Yildirim, Samer Hakmi, Florian M Wagner, Stefan Blankenberg, Hermann Reichenspurner, Edith Lubos
OBJECTIVES: Left-sided unloading during extracorporeal membrane oxygenation (ECMO) therapy is crucial to prevent pulmonary oedema and facilitate ventricular recovery. We present the case of a 55-year-old man under ECMO therapy with pre-existing left ventricular (LV) thrombus formation and in need of ventricular unloading. METHODS: We implanted a 21-Fr TandemHeart Protek Solo trans-septal cannula into the left atrium using a trans-septal approach via the femoral vein...
September 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049608/acute-administration-of-oestradiol-or-progesterone-in-a-spinal-cord-ischaemia-reperfusion-model-in-rats
#20
Leonardo Pessoa Cavalcante, Sueli Gomes Ferreira, Daniel Romano Pereira, Sergio Rodrigues de Moraes, Rafael Simas, Paulina Sannomiya, Ana Cristina Breithaupt-Faloppa, Luiz Felipe Pinho Moreira
OBJECTIVES: Despite research into protective pharmacological adjuncts, paraplegia persists as a dreaded complication after thoracic and thoracoabdominal aortic interventions. Reports on gender-related neurological outcomes after ischaemic and traumatic brain injuries have led to increased interest in hormonal neuroprotective effects and have generated other studies seeking to prove the neuroprotective effects of the therapeutic administration of 17β-oestradiol and of progesterone. We hypothesised that acute administration of oestradiol or progesterone would prevent or attenuate spinal cord ischaemic injury induced by occlusion of the descending thoracic aorta...
September 26, 2017: Interactive Cardiovascular and Thoracic Surgery
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