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https://www.readbyqxmd.com/read/29783645/carbon-dots-doped-with-dysprosium-a-bimodal-nanoprobe-for-mri-and-fluorescence-imaging
#1
Timur Sh Atabaev, Zhonglie Piao, Anara Molkenova
In recent years, functional nanoprobes with multiple imaging modalities have become an emerging field of biomedical research. In this preliminary study, we utilized a facile hydrothermal method for the preparation of magneto-fluorescent bimodal carbon dots doped with dysprosium (Dy-CDs). The prepared Dy-CDs have shown a good colloidal stability in a water solution and strong blue⁻green fluorescence, with a maximum at 452 nm. In addition, the excellent transverse relaxivity of the prepared Dy-CDs (r₂ = 7...
May 18, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29782792/antimicrobial-properties-of-2d-mno-2-and-mos-2-nanomaterials-vertically-aligned-on-graphene-materials-and-ti-3-c-2-mxene
#2
Farbod Alimohammadi, Mohammad Sharifian Gh, Nuwan H Attanayake, Akila C Thenuwara, Yury Gogotsi, Babak Anasori, Daniel R Strongin
Two dimensional (2D) nanomaterials have attracted considerable attention in biomedical and environmental applications due to their antimicrobial activity. In the interest of investigating the primary antimicrobial mode-of-action of 2D nanomaterials, we studied the antimicrobial properties of MnO2 and MoS2 , toward Gram-positive and Gram-negative bacteria. Bacillus subtilis and Escherichia coli bacteria were treated individually with 100 μg/mL of randomly oriented and vertically aligned nanomaterials for 3 h in the dark...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29780995/magnetic-conjugated-polymer-nanoparticles-doped-with-a-europium-complex-for-biomedical-imaging
#3
E Kemal, R Peters, S Bourke, S Fairclough, P Bergstrom-Mann, D M Owen, L Sandiford, L A Dailey, M Green
Self-assembling conjugated polymer nanoparticles containing PVK and PLGA-PEG as a matrix polymer were doped with both a luminescent rare-earth complex and magnetic nanoparticles (SPIONs), giving rise to materials that are both luminescent and magnetic. Nanoparticle sizes ranged from 80-110 nm without SPIONs and showed an increase in size (200-1000 nm) with additional SPION content (11-54%). Quantum yields (QYs) of 24% and 18% were measured for systems without and with 11% SPIONs, respectively. Optical properties were stable and suitable for biological imaging applications...
May 21, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29774897/development-of-highly-sensitive-fluorescent-probes-for-the-detection-of-%C3%AE-galactosidase-activity-application-to-the-real-time-monitoring-of-senescence-in-live-cells
#4
Mauro Safir Filho, Pascal Dao, Maéva Gesson, Anthony R Martin, Rachid Benhida
We report the development of four novel fluorescent probes to monitor the activity of the β-galactosidase enzyme (β-gal), in vitro and in living cells. The fluorophores are based on a 6-amino-styryl-benzothiazole push-pull core and display a strong ICT emission. The probes encompass the fluorescent motif that is connected to a β-d-galactopyranoside moiety through a self-immolative benzyl carbamate linker (βGal-1-4). The screening of four different fluorophores enabled us to access new light-up and two-band ratiometric reporters...
May 18, 2018: Analyst
https://www.readbyqxmd.com/read/29772473/electrophoretic-co-deposition-of-peek-hydroxyapatite-composite-coatings-for-biomedical-applications
#5
Fatih E Baştan, Muhammad Atiq Ur Rehman, Yasemin Yıldıran Avcu, Egemen Avcu, Fatih Üstel, Aldo R Boccaccini
This study focuses on the optimization of electrophoretic deposition (EPD) and suspension parameters for producing PEEK-hydroxyapatite (HA) coatings with feasible microstructure, adhesion strength, and in-vitro bioactivity. Nanostructured hydroxyapatite (HA) micro-granules were incorporated with PEEK to form PEEK-hydroxyapatite composite coatings via EPD. After EPD, a heat-treatment at 375 °C was applied for densification of the coatings and for enhancing the adhesion between the coatings and the substrates...
May 3, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29772346/tackling-bioactive-glass-excessive-in-vitro-bioreactivity-preconditioning-approaches-for-cell-culture-tests
#6
REVIEW
Francesca E Ciraldo, Elena Boccardi, Virginia Melli, Fabian Westhauser, Aldo R Boccaccini
Bioactive glasses (BGs) are being increasingly considered for biomedical applications in bone and soft tissue replacement approaches thanks to their ability to form strong bonding with tissues. However, due to their high reactivity once in contact with water-based solutions BGs rapidly exchange ions with the surrounding environment leading in most cases to an undesired increase of the pH under static in vitro conditions (due to alkaline ion "burst release"), making difficult or even impossible to perform cell culture studies...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29770369/nanomaterial-microbe-cross-talk-physicochemical-principles-and-patho-biological-consequences
#7
REVIEW
D Westmeier, A Hahlbrock, C Reinhardt, J Fröhlich-Nowoisky, S Wessler, C Vallet, U Pöschl, S K Knauer, R H Stauber
The applications of nanoparticles (NPs) are increasing exponentially in consumer products, biotechnology and biomedicine, and humans, as well as the environment, are increasingly being exposed to NPs. Analogously, various (pathogenic) microorganisms are present at all the major exposure and entry sites for NPs in the human body as well as in environmental habitats. However, the field has just started to explore the complex interplay between NPs and microbes and the (patho)biological consequences. Based on recent insights, herein, we critically reviewed the available knowledge about the interaction of NPs with microbes and the analytical investigations including the latest intravital imaging tools...
May 17, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29769713/author-correction-discovery-of-a-selective-catalytic-p300-cbp-inhibitor-that-targets-lineage-specific-tumours
#8
Loren M Lasko, Clarissa G Jakob, Rohinton P Edalji, Wei Qiu, Debra Montgomery, Enrico L Digiammarino, T Matt Hansen, Roberto M Risi, Robin Frey, Vlasios Manaves, Bailin Shaw, Mikkel Algire, Paul Hessler, Lloyd T Lam, Tamar Uziel, Emily Faivre, Debra Ferguson, Fritz G Buchanan, Ruth L Martin, Maricel Torrent, Gary G Chiang, Kannan Karukurichi, J William Langston, Brian T Weinert, Chunaram Choudhary, Peter de Vries, Arthur F Kluge, Michael A Patane, John H Van Drie, Ce Wang, David McElligott, Edward A Kesicki, Ronen Marmorstein, Chaohong Sun, Philip A Cole, Saul H Rosenberg, Michael R Michaelides, Albert Lai, Kenneth D Bromberg
In the originally published version of this Letter, the authors Arthur F. Kluge, Michael A. Patane and Ce Wang were inadvertently omitted from the author list. Their affiliations are: I-to-D, Inc., PO Box 6177, Lincoln, Massachusetts 01773, USA (A.F.K.); Mitobridge, Inc. 1030 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA (M.A.P.); and China Novartis Institutes for BioMedical Research, No. 4218 Jinke Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai 201203, China (C.W.). These authors contributed to the interpretation of results and design of compounds...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29767589/efficient-nonparametric-confidence-bands-for-receiver-operating-characteristic-curves
#9
Pablo Martínez-Camblor, Sonia Pérez-Fernández, Norberto Corral
Receiver operating-characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous (bio)markers. In spite of the existence of a huge number of papers devoted to both theoretical and practical aspects of this topic, the construction of confidence bands has had little impact in the specialized literature. As far as the authors know, in the CRAN there are only three R packages providing receiver operating-characteristic curve confidence regions: plotROC, pROC and fbroc...
June 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29761717/2017-meeting-of-the-national-directors-of-graduate-studies-in-pharmacology-and-physiology
#10
Tanya R Victor, Kaitlyn K Thompson, Joey V Barnett, Kelly D Karpa
The National Directors of Graduate Studies biennial meeting is a forum for directors from pharmacology and physiology graduate programs to discuss challenges and best practices for programs that are preparing trainees to be successful in the biomedical workforce. The 2017 meeting was held on the campus of Stony Brook University in Stony Brook, NY. Over the course of the 3-day event, several themes evolved, including graduate education training and curricula, diversity and career development, and scientific rigor and communication...
June 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29755216/yoga-for-heart-failure-a-review-and-future-research
#11
REVIEW
Paula R Pullen, William S Seffens, Walter R Thompson
Background: Complementary and alternative medicine is a rapidly growing area of biomedical inquiry. Yoga has emerged in the forefront of holistic medical care due to its long history of linking physical, mental, and spiritual well-being. Research in yoga therapy (YT) has associated improved cardiovascular and quality of life (QoL) outcomes for the special needs of heart failure (HF) patients. Aim: The aim of this study is to review yoga intervention studies on HF patients, discuss proposed mechanisms, and examine yoga's effect on physiological systems that have potential benefits for HF patients...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29751530/effect-of-dc-plasma-electrolytic-oxidation-on-surface-characteristics-and-corrosion-resistance-of-zirconium
#12
Maciej Sowa, Wojciech Simka
Zr is a valve metal, the biocompatibility of which is at least on par with Ti. Recently, numerous attempts of the formation of bioactive coatings on Zr by plasma electrolytic oxidation (PEO) in solutions that were based on calcium acetate and calcium β-glycerophosphate were made. In this study, the direct current (DC) PEO of commercially pure zirconium in the solutions that contained Ca(H₂PO₂)₂, Ca(HCOO)₂, and Mg(CH₃COO)₂ was investigated. The treatment was conducted at 75 mA/cm² up to 200, 300, or 400 V...
May 3, 2018: Materials
https://www.readbyqxmd.com/read/29747031/electrospun-polymeric-nanofibres-as-wound-dressings-a-review
#13
REVIEW
Sónia P Miguel, Daniela R Figueira, Déborah Simões, Maximiano P Ribeiro, Paula Coutinho, Paula Ferreira, Ilídio J Correia
Skin wounds have significant morbidity and mortality rates associated. This is explained by the limited effectiveness of the currently available treatments, which in some cases do not allow the reestablishment of the structure and functions of the damaged skin, leading to wound infection and dehydration. These drawbacks may have an impact on the healing process and ultimately prompt patients' death. For this reason, researchers are currently developing new wound dressings that enhance skin regeneration. Among them, electrospun polymeric nanofibres have been regarded as promising tools for improving skin regeneration due to their structural similarity with the extracellular matrix of normal skin, capacity to promote cell growth and proliferation and bactericidal activity as well as suitability to deliver bioactive molecules to the wound site...
May 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29744459/in-vitro-biodegradation-testing-of-mg-alloy-ezk400-and-manufacturing-of-implant-prototypes-using-pm-powder-metallurgy-methods
#14
M Wolff, M Luczak, J G Schaper, B Wiese, M Dahms, T Ebel, R Willumeit-Römer, T Klassen
The study is focussing towards Metal Injection Moulding (MIM) of Mg-alloys for biomedical implant applications. Especially the influence of the sintering processing necessary for the consolidation of the finished part is in focus of this study. In doing so, the chosen high strength EZK400 Mg-alloy powder material was sintered using different sintering support bottom plate materials to evaluate the possibility of iron impurity pick up during sintering. It can be shown that iron pick up took place from the steel bottom plate into the specimen...
September 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29742129/a-snapshot-of-translational-research-funded-by-the-national-institutes-of-health-nih-a-case-study-using-behavioral-and-social-science-research-awards-and-clinical-and-translational-science-awards-funded-publications
#15
Xueying Han, Sharon R Williams, Brian L Zuckerman
The translation of biomedical research from basic knowledge to application has been a priority at the National Institute of Health (NIH) for many years. Tracking the progress of scientific research and knowledge through the translational process is difficult due to variation in the definition of translational research as well as the identification of benchmarks for the spread and application of biomedical research; quantitatively tracking this process is even more difficult. Using a simple and reproducible method to assess whether publications are translational, we examined NIH R01 behavioral and social science research (BSSR) awards funded between 2008 and 2014 to determine whether there are differences in the percent of translational research publications produced by basic and applied research awards...
2018: PloS One
https://www.readbyqxmd.com/read/29739955/surface-modification-of-spions-in-phbv-microspheres-for-biomedical-applications
#16
Maizlinda I Idris, Jan Zaloga, Rainer Detsch, Judith A Roether, Harald Unterweger, Christoph Alexiou, Aldo R Boccaccini
Surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) has been introduced with lauric acid and oleic acid via co-precipitation and thermal decomposition methods, respectively. This modification is required to increase the stability of SPIONs when incorporated in hydrophobic, biodegradable and biocompatible polymers such as poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this work, the solid-in-oil-in-water (S/O/W) emulsion-solvent extraction/evaporation method was utilized to fabricate magnetic polymer microspheres incorporating SPIONs in PHBV...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739392/clinicians-perceptions-of-usefulness-of-the-pubmed4hh-mobile-device-application-for-clinical-decision-making-at-the-point-of-care-a-pilot-study
#17
Kyungsook Gartrell, Caitlin W Brennan, Gwenyth R Wallen, Fang Liu, Karen G Smith, Paul Fontelo
BACKGROUND: Although evidence-based practice in healthcare has been facilitated by Internet access through wireless mobile devices, research on the effectiveness of clinical decision support for clinicians at the point of care is lacking. This study examined how evidence as abstracts and the bottom-line summaries, accessed with PubMed4Hh mobile devices, affected clinicians' decision making at the point of care. METHODS: Three iterative steps were taken to evaluate the usefulness of PubMed4Hh tools at the NIH Clinical Center...
May 8, 2018: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29737411/synthesis-and-characterization-of-manganese-containing-mesoporous-bioactive-glass-nanoparticles-for-biomedical-applications
#18
Qaisar Nawaz, Muhammad Atiq Ur Rehman, Andreas Burkovski, Jochen Schmidt, Ana M Beltrán, Ameen Shahid, Nina K Alber, Wolfgang Peukert, Aldo R Boccaccini
Mesoporous bioactive glass (BG) nanoparticles based in the system: SiO2 -P2 O5 -CaO-MnO were synthesized via a modified Stöber process at various concentrations of Mn (0-7 mol %). The synthesized manganese-doped BG nanoparticles were characterized in terms of morphology, composition, in vitro bioactivity and antibacterial activity. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Brunauer-Emmett-Teller (BET) analysis confirmed that the particles had spherical morphology (mean particle size: 110 nm) with disordered mesoporous structure...
May 8, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29736908/poly-2-oxazoline-hydrogels-state-of-the-art-and-emerging-applications
#19
Tim R Dargaville, Jong-Ryul Park, Richard Hoogenboom
The synthesis of poly(2-oxazoline)s has been known since the 1960s. In the last two decades, they have risen in popularity thanks to improvements in their synthesis and the realization of their potential in the biomedical field due to their "stealth" properties, stimuli responsiveness, and tailorable properties. Even though the bulk of the research to date has been on linear forms of the polymer, they are also of interest for creating network structures due to the relatively easy introduction of reactive functional groups during synthesis that can be cross-linked under a variety of conditions...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29736582/tissue-engineering-strategies-for-osteochondral-repair
#20
F Raquel Maia, Mariana R Carvalho, J Miguel Oliveira, Rui L Reis
Tissue engineering strategies have been pushing forward several fields in the range of biomedical research. The musculoskeletal field is not an exception. In fact, tissue engineering has been a great asset in the development of new treatments for osteochondral lesions. Herein, we overview the recent developments in osteochondral tissue engineering. Currently, the treatments applied in a clinical scenario have shown some drawbacks given the difficulty in regenerating a fully functional hyaline cartilage. Among the different strategies designed for osteochondral regeneration, it is possible to identify cell-free strategies, scaffold-free strategies, and advanced strategies, where different materials are combined with cells...
2018: Advances in Experimental Medicine and Biology
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