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https://www.readbyqxmd.com/read/29327398/ways-of-knowing-on-the-internet-a-qualitative-review-of-cancer-websites-from-a-critical-nursing-perspective
#1
Kristen R Haase, Roanne T Thomas, Wendy Gifford, Lorraine F Holtslander
People diagnosed with cancer typically want information from their doctor or nurse. However, many individuals now turn to the Internet to tackle unmet information needs and to complement healthcare professional information. The purpose of this study was to qualitatively explore the content of commonly searched cancer websites from a critical nursing perspective, as this information is accessible, and allows patients to address their information needs in ways that healthcare professionals cannot. This qualitative examination of websites is informed by Carper's fundamental patterns of knowing and complemented with the critical view to technology espoused by the philosophy of technology...
January 12, 2018: Nursing Inquiry
https://www.readbyqxmd.com/read/29326013/a-cluster-of-multidrug-resistant-mycobacterium-tuberculosis-among-patients-arriving-in-europe-from-the-horn-of-africa-a-molecular-epidemiological-study
#2
Timothy M Walker, Matthias Merker, Astrid M Knoblauch, Peter Helbling, Otto D Schoch, Marieke J van der Werf, Katharina Kranzer, Lena Fiebig, Stefan Kröger, Walter Haas, Harald Hoffmann, Alexander Indra, Adrian Egli, Daniela M Cirillo, Jérôme Robert, Thomas R Rogers, Ramona Groenheit, Anne T Mengshoel, Vanessa Mathys, Marjo Haanperä, Dick van Soolingen, Stefan Niemann, Erik C Böttger, Peter M Keller
BACKGROUND: The risk of tuberculosis outbreaks among people fleeing hardship for refuge in Europe is heightened. We describe the cross-border European response to an outbreak of multidrug-resistant tuberculosis among patients from the Horn of Africa and Sudan. METHODS: On April 29 and May 30, 2016, the Swiss and German National Mycobacterial Reference Laboratories independently triggered an outbreak investigation after four patients were diagnosed with multidrug-resistant tuberculosis...
January 8, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29324741/facilitating-healthcare-decisions-by-assessing-the-certainty-in-the-evidence-from-preclinical-animal-studies
#3
Carlijn R Hooijmans, Rob B M de Vries, Merel Ritskes-Hoitinga, Maroeska M Rovers, Mariska M Leeflang, Joanna IntHout, Kimberley E Wever, Lotty Hooft, Hans de Beer, Ton Kuijpers, Malcolm R Macleod, Emily S Sena, Gerben Ter Riet, Rebecca L Morgan, Kristina A Thayer, Andrew A Rooney, Gordon H Guyatt, Holger J Schünemann, Miranda W Langendam
Laboratory animal studies are used in a wide range of human health related research areas, such as basic biomedical research, drug research, experimental surgery and environmental health. The results of these studies can be used to inform decisions regarding clinical research in humans, for example the decision to proceed to clinical trials. If the research question relates to potential harms with no expectation of benefit (e.g., toxicology), studies in experimental animals may provide the only relevant or controlled data and directly inform clinical management decisions...
2018: PloS One
https://www.readbyqxmd.com/read/29321939/isolation-of-rickettsia-amblyommatis-in-huvec-line
#4
S Santibáñez, A Portillo, A M Palomar, J A Oteo
Rickettsia amblyommatis, formerly named Rickettsia amblyommii and 'Candidatus Rickettsia amblyommii' is an intracellular bacterium belonging to the spotted fever group Rickettsia. It is highly prevalent in Amblyomma americanum and in other Amblyomma spp. throughout the Western Hemisphere. R. amblyommatis has been cultivated in chicken fibroblast, primary embryonated chicken eggs, Vero cells and arthropod-derived cells. Because of the affinity of rickettsiae to invade vascular endothelial cells, we tried to isolate R...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29319501/unit-of-analysis-issues-in-laboratory-based-research
#5
Nick R Parsons, M Dawn Teare, Alice J Sitch
Many studies in the biomedical research literature report analyses that fail to recognise important data dependencies from multilevel or complex experimental designs. Statistical inferences resulting from such analyses are unlikely to be valid and are often potentially highly misleading. Failure to recognise this as a problem is often referred to in the statistical literature as a unit of analysis (UoA) issue. Here, by analysing two example datasets in a simulation study, we demonstrate the impact of UoA issues on study efficiency and estimation bias, and highlight where errors in analysis can occur...
January 10, 2018: ELife
https://www.readbyqxmd.com/read/29318636/a-multicentred-study-to-validate-a-consensus-bleeding-assessment-tool-developed-by-the-biomedical-excellence-for-safer-transfusion-collaborative-for-use-in-patients-with-haematological-malignancy
#6
C Dyer, C R Alquist, M Cole-Sinclair, E Curnow, N M Dunbar, L J Estcourt, R Kaufman, J M Kutner, J McCullough, Z McQuilten, L Potiphar, B Rioux-Masse, S Slichter, A Tinmouth, K Webert, A P Yokoyama, S J Stanworth
BACKGROUND: There continues to be uncertainty about the optimal approach to documenting bleeding data in platelet transfusion trials, with a desire to apply a common assessment tool across all trials. With this in mind, a consensus bleeding assessment tool (BAT) has been developed by the Biomedical Excellence for Safer Transfusion (BEST) collaborative, based on review of data collection forms used in published randomized trials and following content validation with a range of healthcare professionals at seven haematology centres through BEST members...
January 10, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29317627/mapping-the-microscale-origins-of-magnetic-resonance-image-contrast-with-subcellular-diamond-magnetometry
#7
Hunter C Davis, Pradeep Ramesh, Aadyot Bhatnagar, Audrey Lee-Gosselin, John F Barry, David R Glenn, Ronald L Walsworth, Mikhail G Shapiro
Magnetic resonance imaging (MRI) is a widely used biomedical imaging modality that derives much of its contrast from microscale magnetic field patterns in tissues. However, the connection between these patterns and the appearance of macroscale MR images has not been the subject of direct experimental study due to a lack of methods to map microscopic fields in biological samples. Here, we optically probe magnetic fields in mammalian cells and tissues with submicron resolution and nanotesla sensitivity using nitrogen-vacancy diamond magnetometry, and combine these measurements with simulations of nuclear spin precession to predict the corresponding MRI contrast...
January 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29315845/deformable-organic-nanowire-field-effect-transistors
#8
Yeongjun Lee, Jin Young Oh, Taeho Roy Kim, Xiaodan Gu, Yeongin Kim, Ging-Ji Nathan Wang, Hung-Chin Wu, Raphael Pfattner, John W F To, Toru Katsumata, Donghee Son, Jiheong Kang, James R Matthews, Weijun Niu, Mingqian He, Robert Sinclair, Yi Cui, Jeffery B-H Tok, Tae-Woo Lee, Zhenan Bao
Deformable electronic devices that are impervious to mechanical influence when mounted on surfaces of dynamically changing soft matters have great potential for next-generation implantable bioelectronic devices. Here, deformable field-effect transistors (FETs) composed of single organic nanowires (NWs) as the semiconductor are presented. The NWs are composed of fused thiophene diketopyrrolopyrrole based polymer semiconductor and high-molecular-weight polyethylene oxide as both the molecular binder and deformability enhancer...
January 8, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29306081/in-silico-design-of-magnesium-implants-macroscopic-modeling
#9
J A Sanz-Herrera, E Reina-Romo, A R Boccaccini
Magnesium-based biomedical implants offer many advantages versus traditional ones although some challenges are still present. In this context, mathematical modeling and computational simulation may be a useful and complementary tool to evaluate in silico the performance of magnesium biomaterials under different conditions. In this paper, a phenomenologically-based model to simulate magnesium corrosion is developed. The model describes the physico-chemical interactions and evolution of species present in this phenomenon...
December 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29302835/how-non-functioning-pituitary-adenomas-can-affect-health-related-quality-of-life-a-conceptual-model-and-literature-review
#10
REVIEW
Cornelie D Andela, Daniel J Lobatto, Alberto M Pereira, Wouter R van Furth, Nienke R Biermasz
After treatment for a non-functioning pituitary adenoma (NFA) health-related quality of life (HR-QoL) improves considerably. However, the literature about the normalization of HR-QoL after treatment is inconclusive. Some researchers described a persistently decreased HR-QoL compared to reference data, while others did not. Considering this variety in observed HR-QoL outcomes, the aim of the present review was to provide a literature overview of health outcomes in patients with a NFA, using a conceptual HR-QoL model...
January 4, 2018: Pituitary
https://www.readbyqxmd.com/read/29297359/multiple-kernels-learning-based-biological-entity-relationship-extraction-method
#11
Xu Dongliang, Pan Jingchang, Wang Bailing
BACKGROUND: Automatic extracting protein entity interaction information from biomedical literature can help to build protein relation network and design new drugs. There are more than 20 million literature abstracts included in MEDLINE, which is the most authoritative textual database in the field of biomedicine, and follow an exponential growth over time. This frantic expansion of the biomedical literature can often be difficult to absorb or manually analyze. Thus efficient and automated search engines are necessary to efficiently explore the biomedical literature using text mining techniques...
September 20, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29284778/alterations-of-antitumor-and-metabolic-responses-in-l5178y-r-lymphoma-bearing-mice-after-only-30-minute-daily-chronic-stress-exposure
#12
D Caballero-Hernandez, D Najera-Valderrabano, A Valadez-Lira, M Franco-Molina, R Gomez-Flores, P Tamez-Guerra, R Tamez-Guerra, C Rodríguez-Padilla
AIM: In stress research, reducing times of stress induction may contribute to improving the well-being of experimental animals, especially in cancer models, already under physiological distress. To support this idea, we evaluated the effects of a short-timed stress protocol on endocrine, metabolic and immune indicators in mice bearing the L5178Y-R lymphoma. MATERIALS AND METHODS: A 30-minute daily stress protocol was applied for 28 days to healthy and lymphoma-bearing BALB/c mice; body weight, plasma levels of corticosterone, norepinephrine, Th1/Th2 cytokines, insulin, and leptin, were measured...
December 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29283978/review-hibernation-based-approaches-in-the-treatment-of-hemorrhagic-shock
#13
Andrea Wolf, Elizabeth R Lusczek, Gregory J Beilman
Hemorrhagic shock is the leading cause of preventable death after trauma. Hibernation-based treatment approaches have been of increasing interest for various biomedical applications. Due to apparent similarities in tissue perfusion and metabolic activity between severe blood loss and the hibernating state, hibernation-based approaches have also emerged for the treatment of hemorrhagic shock. Research has shown that hibernators are protected from shock-induced injury and inflammation. Utilizing the adaptive mechanisms that prevent injury in these animals may help alleviate the detrimental effects of hemorrhagic shock in non-hibernating species...
December 27, 2017: Shock
https://www.readbyqxmd.com/read/29283423/covalent-organic-frameworks-from-materials-design-to-biomedical-application
#14
REVIEW
Fuli Zhao, Huiming Liu, Salva D R Mathe, Anjie Dong, Jianhua Zhang
Covalent organic frameworks (COFs) are newly emerged crystalline porous polymers with well-defined skeletons and nanopores mainly consisted of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds. Compared with conventional materials, COFs possess some unique and attractive features, such as large surface area, pre-designable pore geometry, excellent crystallinity, inherent adaptability and high flexibility in structural and functional design, thus exhibiting great potential for various applications...
December 28, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29280231/a-biopsychosocial-understanding-of-lower-back-pain-content-analysis-of-online-information
#15
N M Black, S J Sullivan, R Mani
OBJECTIVES: (1) To develop a checklist to assess the representation of biopsychosocial lower back pain (LBP) online information; (2) to analyse publicly accessed online LBP information from a Google search for the degree that psychosocial contributors are described alongside the traditional biomedical approach to explaining LBP; (3) whether websites use information on pain biology to educate on LBP; (4) any inaccurate or false information regarding the mechanisms of LBP and; (5) the amount of websites certified by established benchmarks for quality health information...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29278351/controversies-surrounding-authorship-of-manuscripts-by-industry-employees-academic-and-industry-perspectives
#16
Nathaniel R Smilowitz, James J Ferguson, Giora Weisz
AIMS: The medical device and pharmaceutical industries play an essential role in the development of cardiovascular devices and drugs, and industry employees are frequently listed as co-authors of clinical trials published in peer-reviewed journals. Potential conflicts of interest in biomedical research have attracted significant attention in recent years, but issues and challenges surrounding authors who are industry employees have not received nearly as much scrutiny. METHODS AND RESULTS: We present a comprehensive discussion of the concerns and challenges regarding the role of industry in the authorship of scientific manuscripts...
December 26, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29275969/mobile-applications-in-children-with-cerebral-palsy
#17
M Rodríguez Mariblanca, R Cano de la Cuerda
INTRODUCTION: Cerebral palsy (CP) is one of the most common developmental disorders. Technological development has enabled a transformation of the healthcare sector, which can offer more individualised, participatory, and preventive services. Within this context of new technology applied to the healthcare sector, mobile applications, or apps, constitute a very promising tool for the management of children with CP. OBJECTIVE: The purpose of this article is to perform a systematic review of the information published about various mobile applications either directly related to CP or with potential to be useful in the context of the disease, and to describe, analyse, and classify these applications...
December 21, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29273231/voice-acoustic-analysis-of-pediatric-vocal-nodule-patients-using-ratios-calculated-with-biomedical-image-segmentation
#18
Nagihan Bilal, Turab Selcuk, Selman Sarica, Ahmet Alkan, İsrafil Orhan, Adem Doganer, Saime Sagiroglu, Mehmet Akif Kılıc
OBJECTIVE: The aim of this study was to determine nodules using newly developed software with a computer-assisted visual process technique for the calculation of size. The effects of the ratios of nodule base and width were evaluated with voice acoustic analysis. METHODS: A total of 72 patients with pediatric vocal nodule were evaluated. Nodules were marked with the ImageJ News program on photographs obtained from the video recordings in the videostroboscopic examination and classified according to the Shah et al scale...
December 19, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29261781/accurate-and-fast-feature-selection-workflow-for-high-dimensional-omics-data
#19
Yasset Perez-Riverol, Max Kuhn, Juan Antonio Vizcaíno, Marc-Phillip Hitz, Enrique Audain
We are moving into the age of 'Big Data' in biomedical research and bioinformatics. This trend could be encapsulated in this simple formula: D = S * F, where the volume of data generated (D) increases in both dimensions: the number of samples (S) and the number of sample features (F). Frequently, a typical omics classification includes redundant and irrelevant features (e.g. genes or proteins) that can result in long computation times; decrease of the model performance and the selection of suboptimal features (genes and proteins) after the classification/regression step...
2017: PloS One
https://www.readbyqxmd.com/read/29239240/applications-of-mid-infrared-spectroscopy-in-the-clinical-laboratory-setting
#20
Sander De Bruyne, Marijn M Speeckaert, Joris R Delanghe
Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool. Therefore, it has many potential applications in different fields of clinical laboratory science. Although considerable technological progress has been made to promote biomedical applications of this powerful analytical technique, most clinical laboratory analyses are based on spectroscopic measurements in the visible or ultraviolet (UV) spectrum and the potential role of FTIR spectroscopy still remains unexplored...
December 14, 2017: Critical Reviews in Clinical Laboratory Sciences
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