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https://www.readbyqxmd.com/read/28438919/ecosystem-change-and-human-health-implementation-economics-and-policy
#1
REVIEW
S K Pattanayak, R A Kramer, J R Vincent
Several recent initiatives such as Planetary Health, EcoHealth and One Health claim that human health depends on flourishing natural ecosystems. However, little has been said about the operational and implementation challenges of health-oriented conservation actions on the ground. We contend that ecological-epidemiological research must be complemented by a form of implementation science that examines: (i) the links between specific conservation actions and the resulting ecological changes, and (ii) how this ecological change impacts human health and well-being, when human behaviours are considered...
June 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28436509/covering-the-optical-spectrum-through-collective-rare-earth-doping-of-nagdf4-nanoparticles-806-and-980-nm-excitation-routes
#2
A Skripka, R Marin, A Benayas, P Canton, E Hemmer, F Vetrone
Today, at the frontier of biomedical research, the need has been clearly established for integrating disease detection and therapeutic function in one single theranostic system. Light-emitting nanoparticles are being intensively investigated to fulfil this demand, by continuously developing nanoparticle systems simultaneously emitting in both the UV/visible (light-triggered release and activation of drugs) and the near-infrared (imaging and tracking) spectral regions. In this work, rare-earth (RE) doped nanoparticles (RENPs) were synthesized via a thermal decomposition process and spectroscopically investigated as potential candidates as all-in-one optical imaging, diagnostic and therapeutic agents...
April 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28435186/a-low-power-thermal-based-sensor-system-for-low-air-flow-detection
#3
Akm Arifuzzman, Mohammad Rafiqul Haider, David B Allison
Being able to rapidly detect a low air flow rate with high accuracy is essential for various applications in the automotive and biomedical industries. We have developed a thermal-based low air flow sensor with a low-power sensor readout for biomedical applications. The thermal-based air flow sensor comprises a heater and three pairs of temperature sensors that sense temperature differences due to laminar air flow. The thermal-based flow sensor was designed and simulated by using laminar flow, heat transfer in solids and fluids physics in COMSOL MultiPhysics software...
November 2016: Analog Integrated Circuits and Signal Processing
https://www.readbyqxmd.com/read/28432684/characterization-of-interactions-of-metal-containing-nanoparticles-with-biomolecules-by-ce-an-update-2012-2016
#4
REVIEW
Svetlana S Aleksenko, Magdalena Matczuk, Andrei R Timerbaev
The methodological developments and applications of CE related to studying biotransformations of metal-based nanoscale particles of impending medicinal use are overviewed. This is an update to a previous review article (Aleksenko, S. S., Shmykov, A. Y., Oszwałdowski, S., Timerbaev, A. R., Metallomics 2012, 4, 1141-1148) and it covers the research papers published within the last five years. As was anticipated in that review, CE can now be seen as a customary technique in the analysis of biomolecular interactions that exert an impact on the mechanism of action of nanoparticles, comprising metabolism, delivery, cell processing, and targeting...
April 22, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28429837/fluorescence-based-sensor-for-selective-and-sensitive-detection-of-amoxicillin-amox-in-aqueous-medium-application-to-pharmaceutical-and-biomedical-analysis
#5
Samadhan P Pawar, Laxman S Walekar, Dattatray B Gunjal, Dattatray K Dalavi, Anil H Gore, Prashant V Anbhule, Shivajirao R Patil, Govind B Kolekar
We here for the first time demonstrate an analytical approach for the highly selective and sensitive detection of amoxicillin (Amox) in aqueous medium based on the fluorescence quenching of quantum dots (QDs). The change in fluorescence intensity of mercaptopropionic acid-capped cadmium sulphide (MPA-CdS) QDs is attributed to the increasing concentration of Amox. The results show that the fluorescence quenching of QDs by Amox takes place through both static and dynamic types of quenching mechanism. The fluorescence quenching of QDs with increase in concentration of Amox shows the linear range between 5 μg ml(-1) and 30 μg ml(-1) and the limit of detection (LOD) is 5...
April 21, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28427333/the-experiences-of-physiotherapists-treating-people-with-dementia-who-fracture-their-hip
#6
A J Hall, R Watkins, I A Lang, R Endacott, V A Goodwin
BACKGROUND: It is estimated that people with dementia are approximately three times more likely to fracture their hip than sex and age matched controls. A report by the Chartered Society of Physiotherapy found that this population have poor access to rehabilitation as inpatients and in the community. A recent scoping review found a paucity of research in this area, indeed there has been no qualitative research undertaken with physiotherapists. In order to address this evidence gap, the aim of this current study was to explore the experiences of physiotherapists treating this population...
April 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28426284/participatory-genomic-research-ethical-issues-from-the-bottom-up-to-the-top-down
#7
Heide Aungst, Michelle L McGowan, Jennifer R Fishman
Participatory approaches to genomic research manifest along a continuum from bottom-up citizen-science initiatives designed to liberate scientific inquiry from the constraints of traditional research institutional contexts and professional practices to top-down investigator-initiated studies designed to expose the public to scientific research processes and build their support and enthusiasm for genomic research. With foundations as varied as open science, crowdsourcing, patient advocacy, social media, the digitization of health, and the neoliberalization of academic research, a range of ethical frameworks inform the modes of participatory genomic research...
April 19, 2017: Annual Review of Genomics and Human Genetics
https://www.readbyqxmd.com/read/28416873/collagen-extraction-from-mussel-byssus-a-new-marine-collagen-source-with-physicochemical-properties-of-industrial-interest
#8
F Rodríguez, L Morán, G González, E Troncoso, R N Zúñiga
Mussel byssus is a by-product of mussel production and is a potential source of collagen. The goal of this study was to extract collagen from the byssus of Chilean mussel using an enzymatic method and characterize it. A pepsin-aided extraction method was employed where first an enzymatic hydrolysis at two pepsin/substrate ratios (1:50 or 4:50) and times (4 or 24 h) was done. Extraction was conducted at 80 °C for 24 h, in a 0.5 N acetic acid solution. All samples were analyzed for collagen content, amino acid profile, turbidity, viscosity, solubility, denaturation temperature and surface tension...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28415552/in-vitro-and-in-vivo-characterization-of-anodised-zirconium-as-a-potential-material-for-biomedical-applications
#9
Maria R Katunar, Andrea Gomez Sanchez, Ana Santos Coquillat, Ana Civantos, Enrique Martinez Campos, Josefina Ballarre, Tamara Vico, Matias Baca, Viviana Ramos, Silvia Cere
In vitro studies offer the insights for the understanding of the mechanisms at the tissue-implant interface that will provide an effective functioning in vivo. The good biocompatibility of zirconium makes a good candidate for biomedical applications and the attractive in vivo performance is mainly due to the presence of a protective oxide layer. The aim of this study is to evaluate by in vitro and in vivo approach, the influence of surface modification achieved by anodisation at 30 and 60V on zirconium implants on the first steps of the osseointegration process...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415475/novel-non-cytotoxic-bioactive-and-biodegradable-hybrid-materials-based-on-polyurethanes-tio2-for-biomedical-applications
#10
Dulce M González-García, L Téllez Jurado, R Jiménez-Gallegos, Luis M Rodríguez-Lorenzo
Titanium compounds have demonstrated great interfacial properties with biological tissues whereas a wide variety of polyurethanes have also been successfully probed in medical applications. However, studies about hybrids based on polyurethanes/TiO2 for medical applications are scarce. The aim of this work is to design novel biodegradable hybrid materials based on polyurethanes/TiO2 (80% organic-20% inorganic) and to perform a preliminary study of the potential applications in bone regeneration. The hybrids have been prepared by a sol-gel reaction using titanium isopropoxide as precursor of the inorganic component and polyurethane as the organic one...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415392/macroporous-modified-poly-vinyl-alcohol-hydrogels-with-charged-groups-for-tissue-engineering-preparation-and-in-vitro-evaluation
#11
Maria G Drozdova, Daria S Zaytseva-Zotova, Roman A Akasov, Anna S Golunova, Alexander A Artyukhov, Olga O Udartseva, Elena R Andreeva, Denis E Lisovyy, Michael I Shtilman, Elena A Markvicheva
Poly(vinyl alcohol) (PVA) hydrogels are widely employed for various biomedical applications, including tissue engineering, due to their biocompatibility, high water solubility, low protein adsorption, and chemical stability. However, non-charged surface of PVA-based hydrogels is not optimal for cell adhesion and spreading. Here, cross-linked macroporous hydrogels based on low molecular weight acrylated PVA (Acr-PVA) was synthesized by modification of the pendant alcohol groups on the PVA with glycidyl methacrylate (GMA)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414908/experimental-computational-study-of-carbon-nanotube-effects-on-mitochondrial-respiration-in-silico-nano-qspr-machine-learning-models-based-on-new-raman-spectra-transform-with-markov-shannon-entropy-invariants
#12
Michael González-Durruthy, Luciane C Alberici, Carlos Curti, Zeki Naal, David T Atique-Sawazaki, José M Vázquez-Naya, Humberto González-Díaz, Cristian R Munteanu
The study of selective toxicity of carbon nanotubes (CNTs) on mitochondria (CNT-mitotoxicity) is of major interest for future biomedical applications. In the current work, the mitochondrial oxygen consumption (E3) is measured under three experimental conditions by exposure to pristine and oxidized CNTs (hydroxylated and carboxylated). Respiratory functional assays showed that the information on the CNT Raman spectroscopy could be useful to predict structural parameters of mitotoxicity induced by CNTs. The in vitro functional assays show that the mitochondrial oxidative phosphorylation by ATP-synthase (or state V3 of respiration) was not perturbed in isolated rat-liver mitochondria...
April 25, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28413840/modeling-integration-and-reuse-of-heterogeneous-terminologies-in-faceted-browsing-systems
#13
Daniel R Harris
We integrate heterogeneous terminologies into our category-theoretic model of faceted browsing and show that existing terminologies and vocabularies can be reused as facets in a cohesive, interactive system. Commonly found in online search engines and digital libraries, faceted browsing systems depend upon one or more taxonomies which outline the structure and content of the facets available for user interaction. Controlled vocabularies or terminologies are often externally curated and are available as a reusable resource across systems...
July 2016: Proceedings of the ... IEEE International Conference on Information Reuse and Integration
https://www.readbyqxmd.com/read/28409861/neocolonialism-and-health-care-access-among-marshall-islanders-in-the-united-states
#14
Michael R Duke
In the Marshall Islands, a history of extensive nuclear weapons testing and covert biomedical research, coupled with the U.S.'s ongoing military presence in the country, has severely compromised the health of the local population. Despite the U.S.'s culpability in producing ill health along with high rates of emigration from the islands to the mainland United States, the large portion of Marshallese who reside in the United States face substantial barriers to accessing health care. Drawing from ongoing field research with a Marshallese community in Arkansas, this article explores the multifaceted impediments that U...
April 13, 2017: Medical Anthropology Quarterly
https://www.readbyqxmd.com/read/28389233/zk-drugresist-2-0-a-textminer-to-extract-semantic-relations-of-drug-resistance-from-pubmed
#15
Zoya Khalid, Osman Ugur Sezerman
Extracting useful knowledge from an unstructured textual data is a challenging task for biologists, since biomedical literature is growing exponentially on a daily basis. Building an automated method for such tasks is gaining much attention of researchers. ZK DrugResist is an online tool that automatically extracts mutations and expression changes associated with drug resistance from PubMed. In this study we have extended our tool to include semantic relations extracted from biomedical text covering drug resistance and established a server including both of these features...
April 4, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28388615/should-biomedical-research-be-like-airbnb
#16
Vivien R Bonazzi, Philip E Bourne
The thesis presented here is that biomedical research is based on the trusted exchange of services. That exchange would be conducted more efficiently if the trusted software platforms to exchange those services, if they exist, were more integrated. While simpler and narrower in scope than the services governing biomedical research, comparison to existing internet-based platforms, like Airbnb, can be informative. We illustrate how the analogy to internet-based platforms works and does not work and introduce The Commons, under active development at the National Institutes of Health (NIH) and elsewhere, as an example of the move towards platforms for research...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28386409/low-statistical-power-in-biomedical-science-a-review-of-three-human-research-domains
#17
Estelle Dumas-Mallet, Katherine S Button, Thomas Boraud, Francois Gonon, Marcus R Munafò
Studies with low statistical power increase the likelihood that a statistically significant finding represents a false positive result. We conducted a review of meta-analyses of studies investigating the association of biological, environmental or cognitive parameters with neurological, psychiatric and somatic diseases, excluding treatment studies, in order to estimate the average statistical power across these domains. Taking the effect size indicated by a meta-analysis as the best estimate of the likely true effect size, and assuming a threshold for declaring statistical significance of 5%, we found that approximately 50% of studies have statistical power in the 0-10% or 11-20% range, well below the minimum of 80% that is often considered conventional...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28376391/new-glycolipid-biosurfactants-produced-by-the-yeast-strain-wickerhamomyces-anomalus-ccma-0358
#18
Karla S Teixeira Souza, Eduardo J Gudiña, Zélia Azevedo, Victor de Freitas, Rosane F Schwan, Lígia R Rodrigues, Disney R Dias, José A Teixeira
In this work, biosurfactant production by several yeast strains was evaluated using different culture media. The best results were obtained with the strain Wickerhamomyces anomalus CCMA 0358 growing in a culture medium containing glucose (1g/L) and olive oil (20g/L) as carbon sources. This strain produced 2.6g of biosurfactant per liter after 24h of growth. The crude biosurfactant reduced the surface tension of water to values around 31mN/m, and its critical micelle concentration was 0.9mg/mL. This biosurfactant was characterized through mass spectrometry (MS), and nuclear magnetic resonance (NMR) as a mixture of two different glycolipids, comprising a sugar moiety linked to one or three molecules of oleic acid...
March 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28371558/dynamic-cellular-interactions-with-extracellular-matrix-triggered-by-biomechanical-tuning-of-low-rigidity-supported-lipid-membranes
#19
Setareh Vafaei, Seyed R Tabaei, Kabir H Biswas, Jay T Groves, Nam-Joon Cho
The behavior of cells in a tissue is regulated by chemical as well as physical signals arising from their microenvironment. While gel-based substrates have been widely used for mimicking a range of substrate rigidities, there is a need for the development of low rigidity substrates for mimicking the physical properties of soft tissues. In this study, the authors report the development of a supported lipid bilayer (SLB)-based low rigidity substrate for cell adhesion studies. SLBs are functionalized with either collagen I or fibronectin via covalent, amine coupling to a carboxyl group-modified lipid molecule...
March 30, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28370164/trends-in-age-and-red-blood-cell-donation-habits-among-several-racial-ethnic-minority-groups-in-the-united-states
#20
Mark H Yazer, Ralph Vassallo, Meghan Delaney, Marc Germain, Matthew S Karafin, Merlyn Sayers, Leo van de Watering, Beth H Shaz
BACKGROUND: To meet the needs of a diverse patient population, an adequate supply of red blood cells (RBCs) from ethnic/racial minority donors is essential. We previously described the 10-year changes in minority blood donation in the United States. This study describes donation patterns by donor status, age, and race/ethnicity. STUDY DESIGN AND METHODS: Data on the age and the number of unique black/African American, Hispanic/Latino, Asian, and white RBC donors were obtained from eight US blood collectors for 2006, 2009, 2012, and 2015...
March 28, 2017: Transfusion
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