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https://www.readbyqxmd.com/read/28106145/cd1-and-cd1-porcine-blood-dendritic-cells-are-enriched-for-the-orthologues-of-the-two-major-mammalian-conventional-subsets
#1
Jane C Edwards, Helen E Everett, Miriam Pedrera, Helen Mokhtar, Emanuele Marchi, Ferran Soldevila, Daryan A Kaveh, Philip J Hogarth, Helen L Johns, Javier Nunez-Garcia, Falko Steinbach, Helen R Crooke, Simon P Graham
Conventional dendritic cells (cDC) are professional antigen-presenting cells that induce immune activation or tolerance. Two functionally specialised populations, termed cDC1 and cDC2, have been described in humans, mice, ruminants and recently in pigs. Pigs are an important biomedical model species and a key source of animal protein; therefore further understanding of their immune system will help underpin the development of disease prevention strategies. To characterise cDC populations in porcine blood, DC were enriched from PBMC by CD14 depletion and CD172a enrichment then stained with lineage mAbs (Lin; CD3, CD8α, CD14 and CD21) and mAbs specific for CD172a, CD1 and CD4...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105473/recent-applications-of-the-combination-of-mesoporous-silica-nanoparticles-with-nucleic-acids-development-of-bioresponsive-devices-carriers-and-sensors
#2
REVIEW
Rafael R Castillo, Alejandro Baeza, María Vallet-Regí
The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Such is the importance of these gene-keeping biomacromolecules that even nanomaterials have succumbed to the claimed benefits of DNA and RNA. Currently, there could be found in the literature a practically intractable number of examples reporting the use of combination of nanoparticles with nucleic acids, so boundaries are demanded. Following this premise, this review will only cover the most recent and powerful strategies developed to exploit the possibilities of nucleic acids as biotechnological materials when in combination with mesoporous silica nanoparticles...
January 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28104188/maternal-multiple-micronutrient-supplementation-and-other-biomedical-and-socioenvironmental-influences-on-children-s-cognition-at-age-9-12-years-in-indonesia-follow-up-of-the-summit-randomised-trial
#3
Elizabeth L Prado, Susy K Sebayang, Mandri Apriatni, Siti R Adawiyah, Nina Hidayati, Ayuniarti Islamiyah, Sudirman Siddiq, Benyamin Harefa, Jarrad Lum, Katherine J Alcock, Michael T Ullman, Husni Muadz, Anuraj H Shankar
BACKGROUND: Brain and cognitive development during the first 1000 days from conception are affected by multiple biomedical and socioenvironmental determinants including nutrition, health, nurturing, and stimulation. An improved understanding of the long-term influence of these factors is needed to prioritise public health investments to optimise human development. METHODS: We did a follow-up study of the Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT), a double-blind, cluster-randomised trial of maternal supplementation with multiple micronutrients (MMN) or iron and folic acid (IFA) in Indonesia...
February 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28095799/multidataset-an-r-package-for-encapsulating-multiple-data-sets-with-application-to-omic-data-integration
#4
Carles Hernandez-Ferrer, Carlos Ruiz-Arenas, Alba Beltran-Gomila, Juan R González
BACKGROUND: Reduction in the cost of genomic assays has generated large amounts of biomedical-related data. As a result, current studies perform multiple experiments in the same subjects. While Bioconductor's methods and classes implemented in different packages manage individual experiments, there is not a standard class to properly manage different omic datasets from the same subjects. In addition, most R/Bioconductor packages that have been designed to integrate and visualize biological data often use basic data structures with no clear general methods, such as subsetting or selecting samples...
January 17, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28094261/beyond-the-margins-real-time-detection-of-cancer-using-targeted-fluorophores
#5
REVIEW
Ray R Zhang, Alexandra B Schroeder, Joseph J Grudzinski, Eben L Rosenthal, Jason M Warram, Anatoly N Pinchuk, Kevin W Eliceiri, John S Kuo, Jamey P Weichert
Over the past two decades, synergistic innovations in imaging technology have resulted in a revolution in which a range of biomedical applications are now benefiting from fluorescence imaging. Specifically, advances in fluorophore chemistry and imaging hardware, and the identification of targetable biomarkers have now positioned intraoperative fluorescence as a highly specific real-time detection modality for surgeons in oncology. In particular, the deeper tissue penetration and limited autofluorescence of near-infrared (NIR) fluorescence imaging improves the translational potential of this modality over visible-light fluorescence imaging...
January 17, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28094136/day-and-night-glycaemic-control-with-closed-loop-insulin-delivery-versus-conventional-insulin-pump-therapy-in-free-living-adults-with-well-controlled-type-1-diabetes-an-open-label-randomised-crossover-study
#6
Lia Bally, Hood Thabit, Harald Kojzar, Julia K Mader, Jehona Qerimi-Hyseni, Sara Hartnell, Martin Tauschmann, Janet M Allen, Malgorzata E Wilinska, Thomas R Pieber, Mark L Evans, Roman Hovorka
BACKGROUND: Tight control of blood glucose concentration in people with type 1 diabetes predisposes to hypoglycaemia. We aimed to investigate whether day-and-night hybrid closed-loop insulin delivery can improve glucose control while alleviating the risk of hypoglycaemia in adults with HbA1c below 7·5% (58 mmol/mol). METHODS: In this open-label, randomised, crossover study, we recruited adults (aged ≥18 years) with type 1 diabetes and HbA1c below 7·5% from Addenbrooke's Hospital (Cambridge, UK) and Medical University of Graz (Graz, Austria)...
January 13, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28092680/utilizing-somatic-mutation-data-from-numerous-studies-for-cancer-research-proof-of-concept-and-applications
#7
D Amar, S Izraeli, R Shamir
Large cancer projects measure somatic mutations in thousands of samples, gradually assembling a catalog of recurring mutations in cancer. Many methods analyze these data jointly with auxiliary information with the aim of identifying subtype-specific results. Here, we show that somatic gene mutations alone can reliably and specifically predict cancer subtypes. Interpretation of the classifiers provides useful insights for several biomedical applications. We analyze the COSMIC database, which collects somatic mutations from The Cancer Genome Atlas (TCGA) as well as from many smaller scale studies...
January 16, 2017: Oncogene
https://www.readbyqxmd.com/read/28090431/a-role-for-3d-printing-in-kidney-on-a-chip-platforms
#8
Ryan D Sochol, Navin R Gupta, Joseph V Bonventre
The advancement of "kidney-on-a-chip" platforms - submillimeter-scale fluidic systems designed to recapitulate renal functions in vitro - directly impacts a wide range of biomedical fields, including drug screening, cell and tissue engineering, toxicity testing, and disease modelling. To fabricate kidney-on-a-chip technologies, researchers have primarily adapted traditional micromachining techniques that are rooted in the integrated circuit industry; hence the term, "chip." A significant challenge, however, is that such methods are inherently monolithic, which limits one's ability to accurately recreate the geometric and architectural complexity of the kidney in vivo...
March 2016: Current Transplantation Reports
https://www.readbyqxmd.com/read/28090101/a-novel-mathematical-model-for-determining-faculty-workload
#9
Leo R Fitzpatrick, Carol Millette-Snodgrass, Eman Atef
Objective. To develop a mathematical model for determining faculty workload at a college of pharmacy with a team-based learning curriculum. Methods. Using faculty provided data, our model calculated activity and weighted means in teaching, scholarship and service. Subsequently, these data were used to develop departmental and institutional workload models. Results. For the pharmaceutical and biomedical sciences department, percent faculty activity mean values were greatest for service followed by teaching and scholarship...
November 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28088847/vapor-and-gas-bubble-growth-dynamics-around-laser-irradiated-water-immersed-plasmonic-nanoparticles
#10
Yuliang Wang, Mikhail E Zaytsev, Hai Le The, Jan C T Eijkel, Harold J W Zandvliet, Xuehua Zhang, Detlef Lohse
Microbubbles produced by exposing water-immersed metallic nanoparticles to resonant light play an important role in emerging and efficient plasmonic-enhanced processes for catalytic conversion, solar energy harvesting, biomedical imaging, and cancer therapy. How do these bubbles form, and what is their gas composition? In this paper, the growth dynamics of nucleating bubbles around laser-irradiated, water-immersed Au plasmonic nanoparticles are studied to determine the exact origin of the occurrence and growth of these bubbles...
January 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28086889/hybrid-brain-computer-interface-for-biomedical-cyber-physical-system-application-using-wireless-embedded-eeg-systems
#11
Rifai Chai, Ganesh R Naik, Sai Ho Ling, Hung T Nguyen
BACKGROUND: One of the key challenges of the biomedical cyber-physical system is to combine cognitive neuroscience with the integration of physical systems to assist people with disabilities. Electroencephalography (EEG) has been explored as a non-invasive method of providing assistive technology by using brain electrical signals. METHODS: This paper presents a unique prototype of a hybrid brain computer interface (BCI) which senses a combination classification of mental task, steady state visual evoked potential (SSVEP) and eyes closed detection using only two EEG channels...
January 7, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28080914/tricaine-methanesulfonate-ms-222-sedation-and-anesthesia-in-the-purple-spined-sea-urchin-arbacia-punctulata
#12
Jeffrey R Applegate, Daniel S Dombrowski, Larry Shane Christian, Meredith P Bayer, Craig A Harms, Gregory A Lewbart
The purple-spined sea urchin ( Arbacia punctulata ) is commonly found in shallow waters of the western Atlantic Ocean from the New England area of the United States to the Caribbean. Sea urchins play a major role in ocean ecology, echinoculture, and biomedical research. Additionally, sea urchins are commonly displayed in public aquaria. Baseline parameters were developed in unanesthetized urchins for righting reflex (time to regain oral recumbency) and spine response time to tactile stimulus. Tricaine methanesulfonate (MS-222) was used to sedate and anesthetize purple-spined sea urchins and assess sedation and anesthetic parameters, including adhesion to and release from a vertical surface, times to loss of response to tactile stimulus and recovery of righting reflex, and qualitative observations of induction of spawning and position of spines and pseudopodia...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28079902/phenx-measures-for-phenotyping-rare-genetic-conditions
#13
Michael Phillips, Tracey Grant, Philip Giampietro, Joann Bodurtha, Rodolfo Valdez, Deborah R Maiese, Tabitha Hendershot, Sharon F Terry, Carol M Hamilton
INTRODUCTION: The PhenX Toolkit, an online resource of well-established measures of phenotypes and exposures, now has 16 new measures recommended for assessing rare genetic conditions. MATERIALS AND METHODS: These measures and their protocols were selected by a working group of domain experts with input from the scientific community. RESULTS: The measures, which cover life stages from birth through adulthood, include clinical scales, characterization of rare genetic conditions, bioassays, and questionnaires...
January 12, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28079368/ligand-design-for-isomer-selective-oxorhenium-v-complex-synthesis
#14
Jinyong Liu, Xiaoge Su, Mengwei Han, Dimao Wu, Danielle L Gray, John R Shapley, Charles J Werth, Timothy J Strathmann
Recently, N,N-trans Re(O)(LN-O)2X (LN-O = monoanionic N-O chelates; X = Cl or Br prior to being replaced by solvents or alkoxides) complexes have been found to be superior to the corresponding N,N-cis isomers in the catalytic reduction of perchlorate via oxygen atom transfer. However, reported methods for Re(O)(LN-O)2X synthesis often yield only the N,N-cis complex or a mixture of trans and cis isomers. This study reports a geometry-inspired ligand design rationale that selectively yields N,N-trans Re(O)(LN-O)2Cl complexes...
January 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28079225/bioconjugation-strategies-to-couple-supramolecular-exo-functionalized-palladium-cages-to-peptides-for-biomedical-applications
#15
J Han, A Schmidt, T Zhang, H Permentier, G M M Groothuis, R Bischoff, F E Kühn, P Horvatovich, A Casini
Supramolecular Pd2L4 cages (L = ligand) hold promise as drug delivery systems. With the idea of achieving targeted delivery of the metallacages to tumor cells, the bioconjugation of exo-functionalized self-assembled Pd2L4 cages to peptides following two different approaches is reported for the first time. The obtained bioconjugates were analyzed and identified by high-resolution mass spectrometry.
January 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28074196/ionic-flash-nanoprecipitation-ifnp-for-the-facile-one-step-synthesis-of-inorganic-organic-hybrid-nanoparticles-in-water
#16
N M Pinkerton, L Behar, K Hadri, B Amouroux, C Mingotaud, D R Talham, S Chassaing, J-D Marty
Ionic Flash NanoPrecipitation (iFNP) was evaluated as a novel method for the synthesis of inorganic-organic hybrid nanomaterials and proved to be remarkably effective, fast and practical. To prove the potential of iFNP, various nanostructured GdPO4-based materials of biomedical imaging relevance were easily prepared in a one-step, tunable and highly controlled manner using only water as solvent.
January 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28072567/commentary-on-the-integration-of-model-sharing-and-reproducibility-analysis-to-scholarly-publishing-workflow-in-computational-biomechanics
#17
Ahmet Erdemir, Trent M Guess, Jason P Halloran, Luca Modenese, Jeffrey A Reinbolt, Darryl G Thelen, Brian R Umberger, Ahmet Erdemir, Trent M Guess, Jason P Halloran, Luca Modenese, Jeffrey A Reinbolt, Darryl G Thelen, Brian R Umberger, Brian R Umberger, Ahmet Erdemir, Darryl G Thelen, Trent M Guess, Jeffrey A Reinbolt, Luca Modenese, Jason P Halloran
OBJECTIVE: The overall goal of this paper is to demonstrate that dissemination of models and analyses for assessing the reproducibility of simulation results can be incorporated in the scientific review process in biomechanics. METHODS: As part of a special issue on model sharing and reproducibility in the IEEE Transactions on Biomedical Engineering, two manuscripts on computational biomechanics were submitted: Rajagopal et al., IEEE Trans. Biomed. Eng., 2016 and Schmitz and Piovesan, IEEE Trans...
October 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28071883/individually-stabilized-superparamagnetic-nanoparticles-with-controlled-shell-and-size-leading-to-exceptional-stealth-properties-and-high-relaxivities
#18
Andrea Lassenberger, Andrea Scheberl, Andreas Stadlbauer, Alexander Stiglbauer, Thomas Helbich, Erik Reimhult
Superparamagnetic iron oxide nanoparticles (SPION) have received immense interest for biomedical applications, with the first clinical application as negative contrast agent in magnetic resonance imaging (MRI). However, the first generation MRI contrast agents with dextran-enwrapped, polydisperse iron oxide nanoparticle clusters are limited to imaging of the liver and spleen; this is related to their poor colloidal stability in biological media and inability to evade clearance by the reticuloendothelial system...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28070487/unraveling-the-microbial-and-functional-diversity-of-coamo-thermal-spring-in-puerto-rico-using-metagenomic-library-generation-and-shotgun-sequencing
#19
Ricky Padilla-Del Valle, Luis R Morales-Vale, Carlos Ríos-Velázquez
In Puerto Rico, the microbial diversity of the thermal spring (ThS) in Coamo has never been studied using metagenomics. The focus of our research was to generate a metagenomic library from the ThS of Coamo, Puerto Rico and explore the microbial and functional diversity. The metagenomic library from the ThS waters was generated using direct DNA isolation. High molecular weight (40 kbp) DNA was end-repaired, electro eluted and ligated into a fosmid vector (pCCFOS1); then transduced into Escherichia coli EPI300-T1R using T1 bacteriophages...
March 2017: Genomics Data
https://www.readbyqxmd.com/read/28069023/in-vitro-biological-responses-to-nanofibrillated-cellulose-by-human-dermal-lung-and-immune-cells-surface-chemistry-aspect
#20
Viviana R Lopes, Carla Sanchez-Martinez, Maria Strømme, Natalia Ferraz
BACKGROUND: Nanocellulose, and particularly nanofibrillated cellulose (NFC), has been proposed for a diversity of applications in industry and in the biomedical field. Its unique physicochemical and structural features distinguish nanocellulose from traditional materials and enable its use as an advance nanomaterial. However, its nanoscale features may induce unknown biological responses. Limited studies with NFC are available and the biological impacts of its use have not been thoroughly explored...
January 10, 2017: Particle and Fibre Toxicology
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