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Catherine B MarElia, Melanie N Kuehl, Tiffany A Shemwell, Amy C Alman, Brant R Burkhardt
Aim: PANcreatic-DERived factor (PANDER, FAM3B) is a novel hormone that regulates glucose levels via interaction with both the endocrine pancreas and liver. Prior studies examining PANDER were primarily conducted in murine models or in vitro but little is known regarding the circulating concentration of PANDER in humans, especially with regard to the association of type 2 diabetes (T2D) or overall glycemic regulation. To address this limitation, we performed a cross-sectional analysis of circulating serum PANDER concentration in association with other hormones that serve as either markers of insulin resistance (insulin and adiponectin) or to metabolic parameters of glycemic control such as fasting HbA1c and blood glucose (FBG)...
March 2018: Journal of Clinical & Translational Endocrinology
Piotr Pander, Rachel Bulmer, Ross Martinscroft, Stuart Thompson, Frank W Lewis, Thomas J Penfold, Fernando B Dias, Valery N Kozhevnikov
This article describes a convenient method for the synthesis of ONNO-type tetradentate 6,6'-bis(2-phenoxy)-2,2'-bipyridine (bipyridine bisphenolate, BpyBph) ligands and their platinum(II) complexes. The methodology includes the synthesis of 1,2,4-triazine precursors followed by their transformation to functionalized pyridines by the Boger reaction. Two complementary routes employing 3,3'- and 5,5'-bis-triazines allow a modification of the central pyridine rings in different positions, which was exemplified by the introduction of cyclopentene rings...
March 14, 2018: Inorganic Chemistry
Ramin Pashazadeh, Piotr Henryk Pander, Algirdas Lazauskas, Fernando B Dias, Juozas Vidas Grazulevicius
In this work we report a series of thermally activated delayed fluorescence (TADF) molecules with mechanochromic luminescence (MCL) properties and reversible TADF turn on/off properties in solid state that are induced by the transition between amorphous and crystalline states. Additionally, multicolor altering through external stimulus is demonstrated. All the studied compounds exhibited recovery of the initial states associated with narrower emission spectra. TADF OLEDs fabricated by solution processing rendered high external quantum efficiency up to 10...
February 19, 2018: Journal of Physical Chemistry Letters
Paula Maciel-Silva, Izabela Caldeira, Icaro de Assis Santos, Ana Claudia Oliveira Carreira, Flavia Ramos Siqueira, Eliane Antonioli, Anna Carla Goldberg, José Ernesto Belizário, Humberto Miguel Garay-Malpartida
BACKGROUND: FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative role of this cytokine in prostate tumor progression. METHODS: FAM3B expression was analyzed by quantitative PCR in tumor tissue clinical samples and prostate tumor cell lines. Culture growth and viability of DU145 cell line were evaluated after treatment with either exogenous FAM3B protein obtained from conditioned media (CM) of 293 T cells overexpressing FAM3B or a recombinant FAM3B protein produced in a bacterial host...
January 22, 2018: BMC Cancer
Leo Nicolai, Moritz Schmidbauer, Maximilian Gradel, Sabine Ferch, Sofía Antón, Boj Hoppe, Tanja Pander, Philip von der Borch, Severin Pinilla, Martin Fischer, Konstantinos Dimitriadis
BACKGROUND: Social networking sites, in particular Facebook, are not only predominant in students' social life but are to varying degrees interwoven with the medical curriculum. Particularly, Facebook groups have been identified for their potential in higher education. However, there is a paucity of data on user types, content, and dynamics of study-related Facebook groups. OBJECTIVE: The aim of this study was to identify the role of study-related Facebook group use, characterize medical students that use or avoid using Facebook groups (demographics, participation pattern, and motivation), and analyze student posting behavior, covered topics, dynamics, and limitations in Facebook groups with regards to educational usage...
December 22, 2017: Journal of Medical Internet Research
Xiaoyan Zhang, Weili Yang, Junpei Wang, Yuhong Meng, Youfei Guan, Jichun Yang
Non-alcoholic fatty liver disease (NAFLD) and diabetes are severe public health issues worldwide. The Family with sequence similarity 3 (FAM3) gene family consists of four members designated as FAM3A, FAM3B, FAM3C and FAM3D, respectively. Recently, there had been increasing evidence that FAM3A, FAM3B and FAM3C are important regulators of glucose and lipid metabolism. FAM3A expression is reduced in the livers of diabetic rodents and NAFLD patients. Hepatic FAM3A restoration activates ATP-P2 receptor-Akt and AMPK pathways to attenuate steatosis and hyperglycemia in obese diabetic mice...
April 2018: Metabolism: Clinical and Experimental
Leo Nicolai, Maximilian Gradel, Sofia Antón, Tanja Pander, Anke Kalb, Lisa Köhler, Martin R Fischer, Konstantinos Dimitriadis, Philip von der Borch
Introduction: One of the most important extracurricular aspects of medical studies in Germany is a research thesis completed by most students. This research project often times conveys relevant competencies for the physician's role as scientist. Nevertheless, the choice of the right project remains a challenge. Reasons for this are among others, missing structures for a comprehensive overview of research groups and their respective projects. Description of the project: We developed the online platform Doktabörse as an online marketplace for doctoral research projects...
2017: GMS Journal for Medical Education
Manjeet, B L Pander, R Sharma, S S Dhaka, Ankit Magotra, Kapil Dev
Foot and mouth disease (FMD) is the most contagious disease of mammals and a major threat to animal husbandry sector. In India, vaccination with the inactivated trivalent (O, A and Asia1) vaccine is one proven way for protecting the livestock from FMD. However, many outbreaks have been reported in different parts of the country. Therefore, present study was aimed at elucidating the effects of genetic and non-genetic factors on FMD viral vaccine-elicited immune response in Hardhenu cattle. The effect of season of vaccination was not consistent...
December 2017: Tropical Animal Health and Production
Masato Okazaki, Youhei Takeda, Przemyslaw Data, Piotr Pander, Heather Higginbotham, Andrew P Monkman, Satoshi Minakata
Novel U-shaped donor-acceptor-donor (D-A-D) π-conjugated multi-functional molecules comprising dibenzo[a,j]phenazine (DBPHZ) as an acceptor and phenothiazines (PTZ) as donors have been developed. Most importantly, the D-A-D compounds exhibit not only distinct tricolor-changeable mechanochromic luminescence (MCL) properties but also efficient thermally activated delayed fluorescence (TADF). Quantum chemical calculations, X-ray diffraction analysis, and systematic studies on the photophysical properties indicated that the "two-conformation-switchable" PTZ units play a highly important role in achieving multi-color-changing MCL...
April 1, 2017: Chemical Science
Fenghua Lai, Yan Chen, Huimei Lin, Xuelan Wang, Xiaonan Zhu, Yanbing Li, Haipeng Xiao, Xiaopei Cao
PURPOSE: Pancreatic-derived factor (PANDER) is a pancreatic islet-specific cytokine that co-secretes with insulin. However, its biological function remains largely unknown. We have recently shown that the intestine might be its novel target tissue. The aim of this study was to clarify whether PANDER impacts the production of glucagon-like peptide-1 (GLP-1). METHODS: We treated GLUTag cells from the mouse intestine L cell line with recombinant PANDER protein and hepatic overexpression of PANDER in an obese murine model...
May 24, 2017: Molecular and Cellular Endocrinology
M Mueller, J Pander, J Knott, J Geist
This study compares the effectiveness and representativeness of electrofishing, snorkelling, seining, baited lift netting, multi-mesh gillnetting, baited fish traps, fyke netting, angling and longline fishing, considering three typical lentic flood-plain habitats at different times of day. Electrofishing was by far the most effective method yielding highest species richness, species trait representation and catch per unit of effort (CPUE), followed by seining. For single species like dace Leuciscus leuciscus, European ruffe Gymnocephalus cernua, common bream Abramis brama and silver bream Blicca bjoerkna, seining was more effective than electrofishing...
May 22, 2017: Journal of Fish Biology
Wenxiang Zhang, Siyu Chen, Zhao Zhang, Chen Wang, Chang Liu
The proliferation and migration of vascular smooth muscle cells (VSMCs) play an essential role during the development of cardiovascular diseases (CVDs). While many factors potentially contribute to the abnormal activation of VSMCs, hyperglycemia is generally believed to be a major causative factor. On the other hand, FAM3B (named PANDER for its secretory form) is a uniquely structured protein strongly expressed within and secreted from the endocrine pancreas. FAM3B is co-secreted with insulin from the β-cell upon glucose stimulation and regulates glucose homeostasis...
May 23, 2017: Scientific Reports
Miral M Shehata, Mohamed M Kamal, Mohamed H El-Hefnawy, Hala O El-Mesallamy
AIM: Beta-cell dysfunction is the critical determinant for type 2 diabetes. The novel PANcreatic DERived factor (PANDER) has been identified as interesting islet-secreted cytokine that might be involved in beta-cell dysfunction, a role that has n"ot been clinically elucidated yet. Therefore, this study was designed to study the potential clinical association of this cytokine with beta-cell dysfunction in type 2 diabetes. METHODS: Anthropometric parameters, routine biochemical markers and serum levels of PANDER were measured in 63 diabetic subjects including; recently diagnosed type 2 diabetic patients with duration of diabetes ≤6months and long-standing type 2 diabetic patients with duration of diabetes ≥5years then compared to 16 healthy control volunteers...
April 2017: Journal of Diabetes and its Complications
Françoise Baylis
In this article, I argue that there is no compelling therapeutic 'need' for human nuclear genome transfer (so-called mitochondrial replacement) to prevent mitochondrial diseases caused by mtDNA mutations. At most there is a strong interest in (i.e. 'want' for) this technology on the part of some women and couples at risk of having children with mitochondrial disease, and perhaps also a 'want' on the part of some researchers who see the technology as a useful precedent - one that provides them with 'a quiet way station' in which to refine the micromanipulations techniques essential for other human germline interventions and human cloning...
January 2017: Bioethics
Anna Jerve, Qingming Qu, Sophie Sanchez, Henning Blom, Per Erik Ahlberg
Lophosteus superbus is one of only a handful of probable stem-group osteichthyans known from the fossil record. First collected and described in the late 19th century from the upper Silurian Saaremaa Cliff locality in Estonia, it is known from a wealth of disarticulated scales, fin spines, and bone fragments. In this study we provide the first description of the morphology and paleohistology of a fin spine and scale from Lophosteus using virtual thin sections and 3D reconstructions that were segmented using phase-contrast synchrotron X-ray microtomography...
2016: PeerJ
Severin Pinilla, Leo Nicolai, Maximilian Gradel, Tanja Pander, Martin R Fischer, Philip von der Borch, Konstantinos Dimitriadis
BACKGROUND: Peer mentoring is a powerful pedagogical approach for supporting undergraduate medical students in their learning environment. However, it remains unclear what exactly peer mentoring is and whether and how undergraduate medical students use social media for peer-mentoring activities. OBJECTIVE: We aimed at describing and exploring the Facebook use of undergraduate medical students during their first 2 years at a German medical school. The data should help medical educators to effectively integrate social media in formal mentoring programs for medical students...
October 27, 2015: JMIR Medical Education
Mark G Athanason, Stanley M Stevens, Brant R Burkhardt
This article contains raw and processed data related to research published in "Quantitative Proteomic Profiling Reveals Hepatic Lipogenesis and Liver X Receptor Activation in the PANDER Transgenic Model" (M.G. Athanason, W.A. Ratliff, D. Chaput, C.B. MarElia, M.N. Kuehl, S.M., Jr. Stevens, B.R. Burkhardt (2016)) [1], and was generated by "spike-in" SILAC-based proteomic analysis of livers obtained from the PANcreatic-Derived factor (PANDER) transgenic mouse (PANTG) under various metabolic conditions [1]. The mass spectrometry output of the PANTG and wild-type B6SJLF mice liver tissue and resulting proteome search from MaxQuant 1...
December 2016: Data in Brief
Heiderose Ortwein, Alexander Benz, Petra Carl, Sören Huwendiek, Tanja Pander, Claudia Kiessling
OBJECTIVE: To investigate whether the Verona Coding Definitions of Emotional Sequences to code health providers' responses (VR-CoDES-P) can be used for assessment of medical students' responses to patients' cues and concerns provided in written case vignettes. METHODS: Student responses in direct speech to patient cues and concerns were analysed in 21 different case scenarios using VR-CoDES-P. RESULTS: A total of 977 student responses were available for coding, and 857 responses were codable with the VR-CoDES-P...
February 2017: Patient Education and Counseling
J R Chalmers, E Simpson, C J Apfelbacher, K S Thomas, L von Kobyletzki, J Schmitt, J A Singh, Å Svensson, H C Williams, K Abuabara, V Aoki, M Ardeleanu, M Awici-Rasmussen, S Barbarot, T L Berents, J Block, A Bragg, T Burton, K K Bjerring Clemmensen, A Creswell-Melville, M Dinesen, A Drucker, L Eckert, C Flohr, M Garg, L A A Gerbens, A L B Graff, J Hanifin, D Heinl, R Humphreys, H A Ishii, Y Kataoka, Y A Leshem, B Marquort, M-A Massuel, S Merhand, H Mizutani, H Murota, D F Murrell, T Nakahara, I Nasr, K Nograles, Y Ohya, I Osterloh, J Pander, C Prinsen, L Purkins, M Ridd, T Sach, M-L A Schuttelaar, S Shindo, J Smirnova, A Sulzer, E Synnøve Gjerde, R Takaoka, H Vestby Talmo, M Tauber, F Torchet, A Volke, C-F Wahlgren, S Weidinger, E Weisshaar, A Wollenberg, K Yamaga, C Y Zhao, P I Spuls
This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23-24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instruments for measuring patient-reported symptoms and quality of life for the HOME core outcome set for atopic eczema (AE). Following presentations, which included data from systematic reviews, consensus discussions were held in a mixture of whole group and small group discussions...
July 2016: British Journal of Dermatology
Mark G Athanason, Whitney A Ratliff, Dale Chaput, Catherine B MarElia, Melanie N Kuehl, Stanley M Stevens, Brant R Burkhardt
PANcreatic-DERived factor (PANDER) is a member of a superfamily of FAM3 proteins modulating glycemic levels by metabolic regulation of the liver and pancreas. The precise PANDER-induced hepatic signaling mechanism is still being elucidated and has been very complex due to the pleiotropic nature of this novel hormone. Our PANDER transgenic (PANTG) mouse displays a selective hepatic insulin resistant (SHIR) phenotype whereby insulin signaling is blunted yet lipogenesis is increased, a phenomena observed in type 2 diabetes...
November 15, 2016: Molecular and Cellular Endocrinology
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