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Miral M Shehata, Mohamed M Kamal, Mohamed H El-Hefnawy, Hala O El-Mesallamy
AIM: Beta-cell dysfunction is the critical determinant for type 2 diabetes. The novel PANcreatic DERived factor (PANDER) has been identified as interesting islet-secreted cytokine that might be involved in beta-cell dysfunction, a role that has n"ot been clinically elucidated yet. Therefore, this study was designed to study the potential clinical association of this cytokine with beta-cell dysfunction in type 2 diabetes. METHODS: Anthropometric parameters, routine biochemical markers and serum levels of PANDER were measured in 63 diabetic subjects including; recently diagnosed type 2 diabetic patients with duration of diabetes ≤6months and long-standing type 2 diabetic patients with duration of diabetes ≥5years then compared to 16 healthy control volunteers...
April 2017: Journal of Diabetes and its Complications
Françoise Baylis
In this article, I argue that there is no compelling therapeutic 'need' for human nuclear genome transfer (so-called mitochondrial replacement) to prevent mitochondrial diseases caused by mtDNA mutations. At most there is a strong interest in (i.e. 'want' for) this technology on the part of some women and couples at risk of having children with mitochondrial disease, and perhaps also a 'want' on the part of some researchers who see the technology as a useful precedent - one that provides them with 'a quiet way station' in which to refine the micromanipulations techniques essential for other human germline interventions and human cloning...
January 2017: Bioethics
Anna Jerve, Qingming Qu, Sophie Sanchez, Henning Blom, Per Erik Ahlberg
Lophosteus superbus is one of only a handful of probable stem-group osteichthyans known from the fossil record. First collected and described in the late 19th century from the upper Silurian Saaremaa Cliff locality in Estonia, it is known from a wealth of disarticulated scales, fin spines, and bone fragments. In this study we provide the first description of the morphology and paleohistology of a fin spine and scale from Lophosteus using virtual thin sections and 3D reconstructions that were segmented using phase-contrast synchrotron X-ray microtomography...
2016: PeerJ
Severin Pinilla, Leo Nicolai, Maximilian Gradel, Tanja Pander, Martin R Fischer, Philip von der Borch, Konstantinos Dimitriadis
BACKGROUND: Peer mentoring is a powerful pedagogical approach for supporting undergraduate medical students in their learning environment. However, it remains unclear what exactly peer mentoring is and whether and how undergraduate medical students use social media for peer-mentoring activities. OBJECTIVE: We aimed at describing and exploring the Facebook use of undergraduate medical students during their first 2 years at a German medical school. The data should help medical educators to effectively integrate social media in formal mentoring programs for medical students...
October 27, 2015: JMIR Medical Education
Mark G Athanason, Stanley M Stevens, Brant R Burkhardt
This article contains raw and processed data related to research published in "Quantitative Proteomic Profiling Reveals Hepatic Lipogenesis and Liver X Receptor Activation in the PANDER Transgenic Model" (M.G. Athanason, W.A. Ratliff, D. Chaput, C.B. MarElia, M.N. Kuehl, S.M., Jr. Stevens, B.R. Burkhardt (2016)) [1], and was generated by "spike-in" SILAC-based proteomic analysis of livers obtained from the PANcreatic-Derived factor (PANDER) transgenic mouse (PANTG) under various metabolic conditions [1]. The mass spectrometry output of the PANTG and wild-type B6SJLF mice liver tissue and resulting proteome search from MaxQuant 1...
December 2016: Data in Brief
Heiderose Ortwein, Alexander Benz, Petra Carl, Sören Huwendiek, Tanja Pander, Claudia Kiessling
OBJECTIVE: To investigate whether the Verona Coding Definitions of Emotional Sequences to code health providers' responses (VR-CoDES-P) can be used for assessment of medical students' responses to patients' cues and concerns provided in written case vignettes. METHODS: Student responses in direct speech to patient cues and concerns were analysed in 21 different case scenarios using VR-CoDES-P. RESULTS: A total of 977 student responses were available for coding, and 857 responses were codable with the VR-CoDES-P...
February 2017: Patient Education and Counseling
J R Chalmers, E Simpson, C J Apfelbacher, K S Thomas, L von Kobyletzki, J Schmitt, J A Singh, Å Svensson, H C Williams, K Abuabara, V Aoki, M Ardeleanu, M Awici-Rasmussen, S Barbarot, T L Berents, J Block, A Bragg, T Burton, K K Bjerring Clemmensen, A Creswell-Melville, M Dinesen, A Drucker, L Eckert, C Flohr, M Garg, L A A Gerbens, A L B Graff, J Hanifin, D Heinl, R Humphreys, H A Ishii, Y Kataoka, Y A Leshem, B Marquort, M-A Massuel, S Merhand, H Mizutani, H Murota, D F Murrell, T Nakahara, I Nasr, K Nograles, Y Ohya, I Osterloh, J Pander, C Prinsen, L Purkins, M Ridd, T Sach, M-L A Schuttelaar, S Shindo, J Smirnova, A Sulzer, E Synnøve Gjerde, R Takaoka, H Vestby Talmo, M Tauber, F Torchet, A Volke, C-F Wahlgren, S Weidinger, E Weisshaar, A Wollenberg, K Yamaga, C Y Zhao, P I Spuls
This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23-24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instruments for measuring patient-reported symptoms and quality of life for the HOME core outcome set for atopic eczema (AE). Following presentations, which included data from systematic reviews, consensus discussions were held in a mixture of whole group and small group discussions...
July 2016: British Journal of Dermatology
Mark G Athanason, Whitney A Ratliff, Dale Chaput, Catherine B MarElia, Melanie N Kuehl, Stanley M Stevens, Brant R Burkhardt
PANcreatic-DERived factor (PANDER) is a member of a superfamily of FAM3 proteins modulating glycemic levels by metabolic regulation of the liver and pancreas. The precise PANDER-induced hepatic signaling mechanism is still being elucidated and has been very complex due to the pleiotropic nature of this novel hormone. Our PANDER transgenic (PANTG) mouse displays a selective hepatic insulin resistant (SHIR) phenotype whereby insulin signaling is blunted yet lipogenesis is increased, a phenomena observed in type 2 diabetes...
November 15, 2016: Molecular and Cellular Endocrinology
Maximilian Gradel, Stefan Moder, Leo Nicolai, Tanja Pander, Boj Hoppe, Severin Pinilla, Philip Von der Borch, Martin R Fischer, Konstantinos Dimitriadis
INTRODUCTION: During their formal studies medical students acquire extensive medical expertise. However, the medical profession demands additional competencies, such as those involved in efficient resource allocation, business administration, development, organization, and process management in the healthcare system. At present students are not sufficiently prepared for the physician's role as manager. In response, we designed the seminar course, MeCuM-SiGma, to impart basic knowledge about healthcare policy and management to students of medicine...
2016: GMS Journal for Medical Education
Xiaopei Cao, Chijiao Yang, Fenghua Lai, Zhenzhen Hong, Huimei Lin, Juan Liu, Yanbing Li
AIMS/INTRODUCTION: Pancreatic-derived factor (PANDER) is an important factor involved in obesity, glucose intolerance and abnormal lipid metabolism in animals. Nevertheless, the relationship between PANDER and metabolic syndrome (MetS) in humans has not yet been reported. MATERIALS AND METHODS: To determinate the relationship between PANDER and MetS components, 212 individuals aged between 40 and 65 years were recruited. Fasting plasma PANDER and other variables were measured...
July 2016: Journal of Diabetes Investigation
Agnieszka Owczarczyk-Saczonek, Natalia Zdanowska, Aleksandra Znajewska-Pander, Waldemar Placek
BACKGROUND: Etanercept and other anti-TNF-alpha agents have been indicated as a therapeutic option in severe drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Etanercept has been shown to quickly reduce the detachment of the epidermis and shorten healing time. Cases of etanercept-induced severe adverse drug reactions were also described. MAIN OBSERVATIONS: A 27-year-old woman with a 4-year history of etanercept and sulfasalazine treatment for rheumatoid arthritis was admitted with Stevens-Johnson syndrome...
March 31, 2016: Journal of Dermatological Case Reports
Przemyslaw Data, Piotr Pander, Masato Okazaki, Youhei Takeda, Satoshi Minakata, Andrew P Monkman
A new family of thermally activated delayed fluorescence (TADF) emitters based on U-shaped D-A-D architecture with a novel accepting unit has been developed. All investigated compounds have small singlet-triplet energy splitting (ΔEST ) ranging from 0.02 to 0.20 eV and showed efficient TADF properties. The lowest triplet state of the acceptor unit plays the key role in the TADF mechanism. OLEDs fabricated with these TADF emitters achieved excellent efficiencies up to 16 % external quantum efficiency (EQE)...
May 4, 2016: Angewandte Chemie
Matthias Schäfer, Tanja Pander, Severin Pinilla, Martin R Fischer, Philip von der Borch, Konstantinos Dimitriadis
BACKGROUND: Spontaneous formation of mentoring relationships can be seen as the gold standard in mentoring. Unfortunately, it happens very infrequently. The purpose of structured mentoring programmes is to facilitate the formation of mentoring relationships. This remains a challenging task, especially for large institutions. AIMS: We set out to investigate and compare three methods of matchmaking in the setting of our structured mentoring programme. In a prospective, randomised trial we compared personal matching (PM) by an experienced expert to two different electronic data processing (EDP)-supported matching procedures: "online algorithm" (OA) versus "online search" (OS)...
September 2016: Medical Teacher
Christopher M Humphreys, Samantha McLean, Sarah Schatschneider, Thomas Millat, Anne M Henstra, Florence J Annan, Ronja Breitkopf, Bart Pander, Pawel Piatek, Peter Rowe, Alexander T Wichlacz, Craig Woods, Rupert Norman, Jochen Blom, Alexander Goesman, Charlie Hodgman, David Barrett, Neil R Thomas, Klaus Winzer, Nigel P Minton
BACKGROUND: Clostridium autoethanogenum is an acetogenic bacterium capable of producing high value commodity chemicals and biofuels from the C1 gases present in synthesis gas. This common industrial waste gas can act as the sole energy and carbon source for the bacterium that converts the low value gaseous components into cellular building blocks and industrially relevant products via the action of the reductive acetyl-CoA (Wood-Ljungdahl) pathway. Current research efforts are focused on the enhancement and extension of product formation in this organism via synthetic biology approaches...
2015: BMC Genomics
Matthias Schäfer, Tanja Pander, Severin Pinilla, Martin R Fischer, Philip von der Borch, Konstantinos Dimitriadis
BACKGROUND: Despite the widespread recognition of the importance of mentoring in medical education, valid and reliable instruments for evaluating the relationship of mentors and protégés are lacking. The aim of this study was to develop a feasible instrument to measure the satisfaction with mentoring relationships. METHODS: Based on two existing questionnaires, the authors developed an instrument to evaluate the weighted satisfaction of mentoring relationships, emphasizing the protégés' individual expectations and needs...
2015: BMC Medical Education
Henk Pander Maat, Leo Lentz, David K Raynor
The structure of patient information leaflets (PILs) supplied with medicines in the European Union is largely determined by a regulatory template, requiring a fixed sequence of pre-formulated headings and sub-headings. The template has been criticized on various occasions, but it has never been tested with users. This paper proposes an alternative template, informed by templates used in the USA and Australia, and by previous user testing.The main research question is whether the revision better enables users to find relevant information...
2015: PloS One
James L White, Maor F Baruch, James E Pander Iii, Yuan Hu, Ivy C Fortmeyer, James Eujin Park, Tao Zhang, Kuo Liao, Jing Gu, Yong Yan, Travis W Shaw, Esta Abelev, Andrew B Bocarsly
No abstract text is available yet for this article.
December 9, 2015: Chemical Reviews
Julius Steffen, Markus Grabbert, Tanja Pander, Maximilian Gradel, Lisa-Maria Köhler, Martin R Fischer, Philip von der Borch, Konstantinos Dimitriadis
INTRODUCTION: The importance of research, as promoted by the CanMEDS framework, is widely acknowledged. Many medical students in Germany work on a research project as part of their doctoral thesis whilst still going to medical school. However, a significant amount of projects are abandoned unfinished, which leads to substantial wastage of resources. One reason for this is an information deficit concerning undergraduate research projects. PROJECT DESCRIPTION: To counteract this, we introduced an annual event at LMU Munich called DoktaMed with more than 600 visitors each year...
2015: GMS Zeitschrift Für Medizinische Ausbildung
Jan Pander, Lieke van Huis-Tanja, Stefan Böhringer, Tahar van der Straaten, Hans Gelderblom, Cornelis Punt, Henk-Jan Guchelaar
PURPOSE: Despite expanding options for systemic treatment, survival for metastatic colorectal cancer (mCRC) remains limited and individual response is difficult to predict. In search of pre-treatment predictors, pharmacogenetic research has mainly used a candidate gene approach. Genome wide association (GWA) studies offer the benefit of simultaneously analyzing a large number of SNPs, in both known and still unidentified functional regions. Using a GWA approach, we searched for genetic markers affecting progression free survival (PFS) in mCRC patients treated with first-line capecitabine, oxaliplatin and bevacizumab (CAPOX-B), with or without cetuximab...
2015: PloS One
Whitney A Ratliff, Mark G Athanason, Alicia C Chechele, Melanie N Kuehl, Amanda M Fernandez, Catherine B MarElia, Brant R Burkhardt
PANcreatic-DERived factor (PANDER, FAM3B) has been shown to regulate glycemic levels via interactions with both pancreatic islets and the liver. Although PANDER is predominantly expressed from the endocrine pancreas, recent work has provided sufficient evidence that the liver may also be an additional tissue source of PANDER production. At physiological levels, PANDER is capable of disrupting insulin signaling and promoting increased hepatic glucose production. As shown in some animal models, strong expression of PANDER, induced by viral delivery within the liver, induces hepatic steatosis...
September 15, 2015: Molecular and Cellular Endocrinology
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