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Fam3b

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https://www.readbyqxmd.com/read/26966188/identification-of-fam3d-as-a-new-endogenous-chemotaxis-agonist-for-the-formyl-peptide-receptors
#1
Xinjian Peng, Enquan Xu, Weiwei Liang, Xiaolei Pei, Dixin Chen, Danfeng Zheng, Yang Zhang, Can Zheng, Pingzhang Wang, Shaoping She, Yan Zhang, Jing Ma, Xiaoning Mo, Yingmei Zhang, Dalong Ma, Ying Wang
The family with sequence similarity 3 (FAM3) gene family is a cytokine-like gene family with four members FAM3A, FAM3B, FAM3C and FAM3D. In this study, we found that FAM3D strongly chemoattracted human peripheral blood neutrophils and monocytes. To identify the FAM3D receptor, we used chemotaxis, receptor internalization, Ca(2+) flux and radioligand-binding assays in FAM3D-stimulated HEK293 cells that transiently expressed formyl peptide receptor (FPR)1 or FPR2 to show that FAM3D was a high affinity ligand of these receptors, both of which were highly expressed on the surface of neutrophils, and monocytes and macrophages...
May 1, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/26374847/genetic-dissection-of-the-down-syndrome-critical-region
#2
Xiaoling Jiang, Chunhong Liu, Tao Yu, Li Zhang, Kai Meng, Zhuo Xing, Pavel V Belichenko, Alexander M Kleschevnikov, Annie Pao, Jennifer Peresie, Sarah Wie, William C Mobley, Y Eugene Yu
Down syndrome (DS), caused by trisomy 21, is the most common chromosomal disorder associated with developmental cognitive deficits. Despite intensive efforts, the genetic mechanisms underlying developmental cognitive deficits remain poorly understood, and no treatment has been proven effective. The previous mouse-based experiments suggest that the so-called Down syndrome critical region of human chromosome 21 is an important region for this phenotype, which is demarcated by Setd4/Cbr1 and Fam3b/Mx2. We first confirmed the importance of the Cbr1-Fam3b region using compound mutant mice, which carry a duplication spanning the entire human chromosome 21 orthologous region on mouse chromosome 16 [Dp(16)1Yey] and Ms1Rhr...
November 15, 2015: Human Molecular Genetics
https://www.readbyqxmd.com/read/26123584/hepatic-nutrient-and-hormonal-regulation-of-the-pancreatic-derived-factor-pander-promoter
#3
Whitney A Ratliff, Mark G Athanason, Alicia C Chechele, Melanie N Kuehl, Amanda M Fernandez, Catherine B MarElia, Brant R Burkhardt
PANcreatic-DERived factor (PANDER, FAM3B) has been shown to regulate glycemic levels via interactions with both pancreatic islets and the liver. Although PANDER is predominantly expressed from the endocrine pancreas, recent work has provided sufficient evidence that the liver may also be an additional tissue source of PANDER production. At physiological levels, PANDER is capable of disrupting insulin signaling and promoting increased hepatic glucose production. As shown in some animal models, strong expression of PANDER, induced by viral delivery within the liver, induces hepatic steatosis...
September 15, 2015: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/25679806/f3mb-pander-decreases-mice-hepatic-triglyceride-and-is-associated-with-decreased-dgat1-expression
#4
Xiaoqing Mo, Chijiao Yang, Xuelan Wang, Brant R Burkhardt, Yangbin Li, Haipeng Xia, Xiaopei Cao
OBJECTIVE: Pancreatic-derived factor (PANDER, also named as FAM3B) is secreted by pancreatic α and β cells. Increasing evidence suggests that it may serve a hormonal function related to glycemic and lipid metabolism. In this study, we investigated the effects of PANDER overexpression on hepatic and adipose triglyceride metabolism in high-fat diet-fed male C57BL/6 mice. METHODS: PANDER overexpression was achieved by tail-vein injection of recombinant Ad-PANDER and Ad-GFP injected mice served as a control...
2015: PloS One
https://www.readbyqxmd.com/read/25217499/enhanced-glucose-tolerance-in-pancreatic-derived-factor-pander-knockout-c57bl-6-mice
#5
Shari L Moak, Grace C Dougan, Catherine B MarElia, Whitney A Danse, Amanda M Fernandez, Melanie N Kuehl, Mark G Athanason, Brant R Burkhardt
Pancreatic-derived factor (PANDER; also known as FAM3B) is a uniquely structured protein strongly expressed within and secreted from the endocrine pancreas. PANDER has been hypothesized to regulate fasting and fed glucose homeostasis, hepatic lipogenesis and insulin signaling, and to serve a potential role in the onset or progression of type 2 diabetes (T2D). Despite having potentially pivotal pleiotropic roles in glycemic regulation and T2D, there has been limited generation of stable animal models for the investigation of PANDER function, and there are no models on well-established genetic murine backgrounds for T2D...
November 2014: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/25173755/integrative-identification-of-epstein-barr-virus-associated-mutations-and-epigenetic-alterations-in-gastric-cancer
#6
Qiaoyi Liang, Xiaotian Yao, Senwei Tang, Jingwan Zhang, Tung On Yau, Xiaoxing Li, Ceen-Ming Tang, Wei Kang, Raymond W M Lung, Jing Woei Li, Ting Fung Chan, Rui Xing, Youyong Lu, Kwok Wai Lo, Nathalie Wong, Ka Fai To, Chang Yu, Francis K L Chan, Joseph J Y Sung, Jun Yu
BACKGROUND & AIMS: The mechanisms by which Epstein-Barr virus (EBV) contributes to the development of gastric cancer are unclear. We investigated EBV-associated genomic and epigenomic variations in gastric cancer cells and tumors. METHODS: We performed whole-genome, transcriptome, and epigenome sequence analyses of a gastric adenocarcinoma cell line (AGS cells), before and after EBV infection. We then looked for alterations in gastric tumor samples, with (n = 34) or without (n = 100) EBV infection, collected from patients at the Prince of Wales Hospital, Chinese University of Hong Kong (from 1998 through 2004), or the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (from 1999 through 2006)...
December 2014: Gastroenterology
https://www.readbyqxmd.com/read/24468680/pander-transgenic-mice-display-fasting-hyperglycemia-and-hepatic-insulin-resistance
#7
Claudia E Robert-Cooperman, Grace C Dougan, Shari L Moak, Mark G Athanason, Melanie N Kuehl, Harris Bell-Temin, Stanley M Stevens, Brant R Burkhardt
PANcreatic-DERived factor (PANDER, FAM3B) is a novel protein that is highly expressed within the endocrine pancreas and to a lesser degree in other tissues. Under glucose stimulation, PANDER is co-secreted with insulin from the β-cell. Despite prior creation and characterization of acute hepatic PANDER animal models, the physiologic function remains to be elucidated from pancreas-secreted PANDER. To determine this, in this study, a transgenic mouse exclusively overexpressing PANDER from the endocrine pancreas was generated...
March 2014: Journal of Endocrinology
https://www.readbyqxmd.com/read/24043211/whole-genome-expression-profiling-and-screening-for-differentially-expressed-cytokine-genes-in-human-bone-marrow-endothelial-cells-treated-with-humoral-inhibitors-in-liver-cirrhosis
#8
Bo Gao, Wang Sun, Xianqi Wang, Xu Jia, Biao Ma, Yu Chang, Weihui Zhang, Dongbo Xue
Bone marrow endothelial cells (BMECs) are important components of the hematopoietic microenvironment in bone marrow, and they can secrete several types of cytokines to regulate the functions of hematopoietic stem/progenitor cells. To date, it is unknown whether BMECs undergo functional changes and lead to hematopoietic abnormalities in cases of liver cirrhosis (LC). In the present study, whole genome microarray analysis was carried out to detect differentially expressed genes in human BMECs treated for 48 h with medium supplemented with 20% pooled sera from 26 patients with LC or 10 healthy volunteers as the control group...
November 2013: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/24041763/human-chromosome-21-orthologous-region-on-mouse-chromosome-17-is-a-major-determinant-of-down-syndrome-related-developmental-cognitive-deficits
#9
Li Zhang, Kai Meng, Xiaoling Jiang, Chunhong Liu, Annie Pao, Pavel V Belichenko, Alexander M Kleschevnikov, Sheena Josselyn, Ping Liang, Ping Ye, William C Mobley, Y Eugene Yu
Trisomy 21 (Down syndrome, DS) is the most common genetic cause of developmental cognitive deficits, and the so-called Down syndrome critical region (DSCR) has been proposed as a major determinant of this phenotype. The regions on human chromosome 21 (Hsa21) are syntenically conserved on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. DSCR is conserved between the Cbr1 and Fam3b genes on Mmu16. Ts65Dn mice carry three copies of ∼100 Hsa21 gene orthologs on Mmu16 and exhibited impairments in the Morris water maze and hippocampal long-term potentiation (LTP)...
February 1, 2014: Human Molecular Genetics
https://www.readbyqxmd.com/read/23855304/family-with-sequence-similarity-3-gene-family-and-nonalcoholic-fatty-liver-disease
#10
REVIEW
Jichun Yang, Youfei Guan
Nonalcoholic fatty liver disease (NAFLD) comprises a disease spectrum ranging from simple steatosis (fatty liver) and nonalcoholic steatohepatitis to fibrosis and cirrhosis. NAFLD has become the leading cause of chronic liver diseases as well as liver-related morbidity and mortality worldwide. NAFLD is also associated with increased risk of cardiovascular diseases, hyperlipidemia, and type 2 diabetes. Insulin resistance in adipose tissues and the liver plays crucial roles in the progression of NAFLD. The family with sequence similarity 3 (FAM3) gene family is a cytokine-like gene family with four members designated FAM3A, FAM3B, FAM3C, and FAM3D, respectively...
August 2013: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/23333428/fam3b-pander-and-fam3c-ilei-represent-a-distinct-class-of-signaling-molecules-with-a-non-cytokine-like-fold
#11
Patrik Johansson, Jenny Bernström, Tracy Gorman, Linda Oster, Stefan Bäckström, Fritz Schweikart, Bingze Xu, Yafeng Xue, Lovisa Holmberg Schiavone
The FAM3 superfamily is predicted to contain classical four-helix bundle cytokines, featuring a typical up-up-down-down fold. Two members of FAM3 have been extensively studied. FAM3B PANDER has been shown to regulate glucose homeostasis and β cell function, whereas the homologous FAM3C ILEI has been shown to be involved in epithelial-mesenchymal transition and cancer. Here, we present a three-dimensional structure of a FAM3 protein, murine PANDER. Contrary to previous suggestions, PANDER exhibits a globular β-β-α fold...
February 5, 2013: Structure
https://www.readbyqxmd.com/read/23300138/a-genome-wide-association-study-of-genetic-loci-that-influence-tumour-biomarkers-cancer-antigen-19-9-carcinoembryonic-antigen-and-%C3%AE-fetoprotein-and-their-associations-with-cancer-risk
#12
Meian He, Chen Wu, Jianfeng Xu, Huan Guo, Handong Yang, Xiaomin Zhang, Jielin Sun, Dianke Yu, Li Zhou, Tao Peng, Yunfeng He, Yong Gao, Jing Yuan, Qifei Deng, Xiayun Dai, Aihua Tan, Yingying Feng, Haiying Zhang, Xinwen Min, Xiaobo Yang, Jiang Zhu, Kan Zhai, Jiang Chang, Xue Qin, Wen Tan, Yanling Hu, Mingjian Lang, Sha Tao, Yuanfeng Li, Yi Li, Junjie Feng, Dongfeng Li, Seong-Tae Kim, Shijun Zhang, Hongxing Zhang, S Lilly Zheng, Lixuan Gui, Youjie Wang, Sheng Wei, Feng Wang, Weimin Fang, Yuan Liang, Yun Zhai, Weihong Chen, Xiaoping Miao, Gangqiao Zhou, Frank B Hu, Dongxin Lin, Zengnan Mo, Tangchun Wu
OBJECTIVE: Tumour biomarkers are used as indicators for cancer screening and as predictors for therapeutic responses and prognoses in cancer patients. We aimed to identify genetic loci that influence concentrations of cancer antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) and α fetoprotein (AFP), and investigated the associations between the significant single nucleotide polymorphisms (SNPs) with risks of oesophageal squamous cell (OSCC), pancreatic and hepatocellular cancers. DESIGN: We carried out a genome wide association study on plasma CA19-9, CEA and AFP concentrations in 3451 healthy Han Chinese and validated the results in 10 326 individuals...
January 2014: Gut
https://www.readbyqxmd.com/read/23246487/knockdown-of-fam3b-triggers-cell-apoptosis-through-p53-dependent-pathway
#13
Haiwei Mou, Zongmeng Li, Pengle Yao, Shu Zhuo, Wei Luan, Bo Deng, Lihua Qian, Mengmei Yang, Hong Mei, Yingying Le
FAM3B, also named PANDER, is a cytokine-like protein identified in 2002. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B is also expressed by other tissues but its basic function is unclear. In this study, we found that FAM3B was expressed in mouse colon, intestine, liver and lung tissues and multiple types of cell lines, including murine pancreatic β-cell (Min6), microglia (N9) and muscle cell (C2C12); human colon cancer cells (HCT8, HCT116, HT29), hepatocyte (HL-7702), hepatocellular carcinoma cell (SMMC-7721) and lung carcinoma cell (A549)...
March 2013: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/23059759/a-non-secretory-form-of-fam3b-promotes-invasion-and-metastasis-of-human-colon-cancer-cells-by-upregulating-slug-expression
#14
Zongmeng Li, Haiwei Mou, Ting Wang, Jing Xue, Bo Deng, Lihua Qian, Ye Zhou, Wanghua Gong, Ji Ming Wang, Guohao Wu, Cheng-Fu Zhou, Jing Fang, Yingying Le
FAM3B mRNA has been predicted to have multiple splicing forms. Its secretory form PANDER is decreased in gastric cancers with high invasiveness and metastasis. Here we found that its non-secretory form FAM3B-258 was highly expressed in most colon cancer cell lines and colorectal adenocarcinoma tissues but not hepatocellular carcinoma, lung carcinoma and pancreatic adenocarcinoma cell lines. Elevation of FAM3B-258 was associated with poor cancer cell differentiation. Stable overexpression of FAM3B-258 in colon cancer cells downregulated adhesion proteins, upregulated Slug and Cdc42, promoted cell migration and invasion in vitro and metastasis in nude mice...
January 28, 2013: Cancer Letters
https://www.readbyqxmd.com/read/21664946/upregulation-of-pancreatic-derived-factor-fam3b-expression-in-pancreatic-%C3%AE-cells-by-mcp-1-ccl2
#15
Xinwei Hou, Oumei Wang, Zongmeng Li, Haiwei Mou, Juan Chen, Bo Deng, Lihua Qian, Xiaolong Liu, Yingying Le
Pancreatic derived factor (PANDER, FAM3B) is a peptide mainly synthesized and secreted by pancreatic β-cells. PANDER is proposed to be involved in regulation of β-cell function under physiological conditions and impairment of β-cell function under pathological conditions. MCP-1 (CCL2) is expressed by normal pancreatic islets and has been implicated in inflammation related pancreatic disorders. We examined the effect of MCP-1 on PANDER expression by using murine pancreatic β-cell line MIN6 and pancreatic islets...
August 22, 2011: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/21664909/pancreatic-derived-factor-novel-hormone-pandering-to-glucose-regulation
#16
REVIEW
Camella G Wilson, Claudia E Robert-Cooperman, Brant R Burkhardt
PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules that were initially described in 2002. PANDER expression is primarily localized to the endocrine pancreas and is secreted from both pancreatic α and β-cells. Initial characterization of PANDER revealed a potential role in pancreatic islet apoptosis. However, recent animal models have indicated PANDER functions as a hormone by regulating glucose levels via interaction with both the liver and the endocrine pancreas...
July 21, 2011: FEBS Letters
https://www.readbyqxmd.com/read/21113299/cytokines-in-the-progression-of-pancreatic-%C3%AE-cell-dysfunction
#17
Chunjiong Wang, Youfei Guan, Jichun Yang
The dysfunction of pancreatic β-cell and the reduction in β-cell mass are the decisive events in the progression of type 2 diabetes. There is increasing evidence that cytokines play important roles in the procedure of β-cell failure. Cytokines, such as IL-1β, IFN-γ, TNF-α, leptin, resistin, adiponectin, and visfatin, have been shown to diversely regulate pancreatic β-cell function. Recently, islet-derived cytokine PANcreatic DERived factor (PANDER or FAM3B) has also been demonstrated to be a regulator of islet β-cell function...
2010: International Journal of Endocrinology
https://www.readbyqxmd.com/read/20638985/characterization-of-the-expression-localization-and-secretion-of-pander-in-alpha-cells
#18
Jason R Carnegie, Claudia E Robert-Cooperman, Jianmei Wu, Robert A Young, Bryan A Wolf, Brant R Burkhardt
The novel islet-specific protein PANcreatic DERived Factor (PANDER; FAM3B) has been extensively characterized with respect to the beta-cell, and these studies suggest a potential function for PANDER in the regulation of glucose homeostasis. Little is known regarding PANDER in pancreatic -cells, which are critically involved in maintaining euglycemia. Here we present the first report elucidating the expression and regulation of PANDER within the alpha-cell. Pander mRNA and protein are detected in alpha-cells, with primary localization to a glucagon-negative granular cytosolic compartment...
August 30, 2010: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/20566664/targeted-disruption-of-pancreatic-derived-factor-pander-fam3b-impairs-pancreatic-beta-cell-function
#19
Claudia E Robert-Cooperman, Jason R Carnegie, Camella G Wilson, Jichun Yang, Joshua R Cook, Jianmei Wu, Robert A Young, Bryan A Wolf, Brant R Burkhardt
OBJECTIVE: Pancreatic-derived factor (PANDER, FAM3B) is a pancreatic islet-specific cytokine-like protein that is secreted from beta-cells upon glucose stimulation. The biological function of PANDER is unknown, and to address this we generated and characterized a PANDER knockout mouse. RESEARCH DESIGN AND METHODS: To generate the PANDER knockout mouse, the PANDER gene was disrupted and its expression was inhibited by homologous recombination via replacement of the first two exons, secretion signal peptide and transcriptional start site, with the neomycin gene...
September 2010: Diabetes
https://www.readbyqxmd.com/read/18708173/pdx-1-interaction-and-regulation-of-the-pancreatic-derived-factor-pander-fam3b-promoter
#20
Brant R Burkhardt, Joshua R Cook, Robert A Young, Bryan A Wolf
Pancreatic Derived Factor (PANDER) is a novel cytokine-like protein dominantly expressed within the endocrine pancreas. Our previous study demonstrated that the PANDER promoter was both tissue-specific and glucose-responsive. Surrounding the PANDER transcriptional start site are several putative A- and E-Box elements that may bind to the various pancreatic transcriptional factors of MafA, BETA2/NeuroD, and Pancreatic Duodenal Homeobox-1 (PDX-1). To characterize the transcriptional regulatory factors involved in PANDER gene expression, we performed co-transfection reporter gene analysis and demonstrated upregulation by all three transcription factors, with the greatest individual increase stemming from PDX-1...
October 2008: Biochimica et Biophysica Acta
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