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https://www.readbyqxmd.com/read/28209104/impact-of-gluten-free-diet-on-quality-of-life-in-celiac-patients
#1
R Borghini, M Di Tola, E Salvi, C Isonne, M Puzzono, M Marino, G Donato, A Picarelli
BACKGROUND AND AIM: Celiac disease (CD) is a common gluten-related disorder, whose only treatment is a gluten-free diet (GFD). Since a unique view on psychological consequences of a GFD still lacks, our aim was to assess the quality of life (QoL) and the depression state in symptomatic CD patients after GFD. Socio-demographic features were considered. PATIENTS AND METHODS: 210 adult CD patients were recruited and divided into 3 groups : 70 newly diagnosed patients (​Group A​),70 patients who have been on GFD for 6-12 months (​Group B​), and 70 patients who have been on GFD for more than 12 months (​Group C​)...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28188747/high-incidence-of-celiac-disease-in-a-long-term-study-of-adolescents-with-susceptibility-genotypes
#2
Edwin Liu, Fran Dong, Anna E Barón, Iman Taki, Jill M Norris, Brigitte I Frohnert, Edward J Hoffenberg, Marian Rewers
BACKGROUND & AIMS: Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area. METHODS: We collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph's Hospital in Denver, from the Diabetes Autoimmunity Study in the Young. Subjects with susceptibility genotypes for celiac disease and type 1 diabetes were followed for up to 20 years for development of tissue transglutaminase autoantibodies (tTGA)...
February 7, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28188172/t-cell-repertoires-in-refractory-coeliac-disease
#3
Julia Ritter, Karin Zimmermann, Korinna Jöhrens, Stefanie Mende, Anke Seegebarth, Britta Siegmund, Steffen Hennig, Kremena Todorova, Andreas Rosenwald, Severin Daum, Michael Hummel, Michael Schumann
OBJECTIVE: Refractory coeliac disease (RCD) is a potentially hazardous complication of coeliac disease (CD). In contrast to RCD type I, RCD type II is a precursor entity of enteropathy-associated T-cell lymphoma (EATL), which is associated with clonally expanding T-cells that are also found in the sequentially developing EATL. Using high-throughput sequencing (HTS), we aimed to establish the small-intestinal T-cell repertoire (TCR) in CD and RCD to unravel the role of distinct T-cell clonotypes in RCD pathogenesis...
February 10, 2017: Gut
https://www.readbyqxmd.com/read/28186337/impaired-intestinal-cholecystokinin-secretion-a-fascinating-but-overlooked-link-between-celiac-disease-and-cholesterol-gallstone-disease
#4
REVIEW
Helen H Wang, Min Liu, Xiaodan Li, Piero Portincasa, David Q-H Wang
BACKGROUND: Celiac disease is a chronic, small intestinal, immune-mediated enteropathy caused by a permanent intolerance to dietary gluten in genetically predisposed individuals. Clinical studies have found that intestinal cholecystokinin secretion and gallbladder emptying in response to a fatty meal are impaired before celiac patients start the gluten-free diet (GFD). DESIGN: However, it was never really appreciated whether celiac disease is associated with gallstones because there were very few studies investigating the mechanism underlying the impact of celiac disease on the pathogenesis of gallstones...
February 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28178205/gluten-contamination-in-naturally-or-labeled-gluten-free-products-marketed-in-italy
#5
Anil K Verma, Simona Gatti, Tiziana Galeazzi, Chiara Monachesi, Lucia Padella, Giada Del Baldo, Roberta Annibali, Elena Lionetti, Carlo Catassi
BACKGROUND: A strict and lifelong gluten-free diet is the only treatment of celiac disease. Gluten contamination has been frequently reported in nominally gluten-free products. The aim of this study was to test the level of gluten contamination in gluten-free products currently available in the Italian market. METHOD: A total of 200 commercially available gluten-free products (including both naturally and certified gluten-free products) were randomly collected from different Italian supermarkets...
February 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28177956/optimizing-the-diagnosis-of-celiac-disease
#6
Michelle Shui Yee Lau, David Surendran Sanders
PURPOSE OF REVIEW: The diagnostic approach in celiac disease is continuously evolving as our understanding of its pathophysiology improves. This review aims to provide a summary of contemporary work that supports optimization of the diagnosis of this common yet underdiagnosed condition. RECENT FINDINGS: The recently updated National Institute of Clinical Excellence and European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines and the contentious biopsy-free diagnostic approach will be discussed...
February 7, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28173007/p711-vegetarian-or-gluten-free-diet-in-patients-with-ibd-associated-with-lower-psychological-well-being-and-quality-of-life-but-no-indication-of-beneficial-effects-on-course-of-disease
#7
P Schreiner, J-B Rossel, J Zeitz, B Misselwitz, S Scharl, M Scharl, P Frei, S Vavricka, V Pittet, G Rogler, L Biedermann
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28169607/the-gluten-free-diet-can-oats-and-wheat-starch-be-part-of-it
#8
J Rainer Poley
Objective and Conclusion: Uncertainty still exists about the use of oats and wheat starch as part of a gluten-free diet in patients with celiac disease (CD). This review should help to clarify the issues at hand. Whereas uncontaminated (from gluten/gliadin) oats and oats from cultivars not containing celiac-activating sequences of proline and glutamine can be used without risk of intestinal damage, wheat starch should not be used, unless it is free of gluten-that is, deglutinized-because even small amounts of gluten over time are able to induce small intestinal mucosal damage...
January 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28168522/no-association-between-gluten-sensitivity-and-amyotrophic-lateral-sclerosis
#9
Anne E Visser, Raha Pazoki, Sara L Pulit, Wouter van Rheenen, Joost Raaphorst, Anneke J van der Kooi, Isis Ricaño-Ponce, Cisca Wijmenga, Henny G Otten, Jan H Veldink, Leonard H van den Berg
To examine evidence for a role of gluten sensitivity (GS) or celiac disease (CD) in ALS etiology, we included participants from a population-based case-control study in The Netherlands between January 2006 and December 2015. We compared levels and seroprevalence of IgA antibodies to tissue transglutaminase 6 (TG6) in 359 ALS patients and 359 controls, and to transglutaminase 2 (TG2) and endomysium (EMA) in 199 ALS patients and 199 controls. Questionnaire data on 1829 ALS patients and 3920 controls were examined for CD or gluten-free diets (GFD)...
February 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28166100/the-unintended-consequences-of-a-gluten-free-diet
#10
Catherine M Bulka, Matthew A Davis, Margaret R Karagas, Habibul Ahsan, Maria Argos
No abstract text is available yet for this article.
February 1, 2017: Epidemiology
https://www.readbyqxmd.com/read/28159249/sourdough-fermentation-and-chestnut-flour-in-gluten-free-bread-a-shelf-life-evaluation
#11
Massimiliano Rinaldi, Maria Paciulli, Augusta Caligiani, Francesca Scazzina, Emma Chiavaro
The effect of sourdough fermentation combined with chestnut flour was investigated for improving technological and nutritional quality of gluten-free bread during 5day shelf life by means of chemico-physical and nutritional properties. Sourdough fermentation by itself and with chestnut flour reduced volume of loaves and heterogeneity in crumb grain. Sourdough technology allowed increasing crumb moisture content with no significant variations during shelf-life. Chestnut flour darkened crumb and crust while no effects on colour were observed for sourdough...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28153851/transverse-myelitis-as-manifestation-of-celiac-disease-in-a-toddler
#12
Hilde Krom, Fleur Sprangers, René van den Berg, Marc Alexander Benninga, Angelika Kindermann
We present a 17-month-old girl with rapidly progressive unwillingness to sit, stand, play, and walk. Furthermore, she lacked appetite, vomited, lost weight, and had an iron deficiency. Physical examination revealed a cachectic, irritable girl with a distended abdomen, dystrophic legs with paraparesis, disturbed sensibility, and areflexia. An MRI scan revealed abnormal high signal intensity on T2-weighted images in the cord on the thoracic level, without cerebral abnormalities, indicating transverse myelitis (TM)...
February 2, 2017: Pediatrics
https://www.readbyqxmd.com/read/28153484/magnetic-resonance-enterography-in-pediatric-celiac-disease
#13
Gonca Koc, Selim Doganay, Eylem Sevinc, Kemal Deniz, Govind Chavhan, Sureyya B Gorkem, Neslihan Karacabey, Mehmet S Dogan, Abdulhakim Coskun, Duran Aslan
OBJECTIVE: To assess if magnetic resonance enterography is capable of showing evidence/extent of disease in pediatric patients with biopsy-proven celiac disease by comparing with a control group, and to correlate the magnetic resonance enterography findings with anti-endomysial antibody level, which is an indicator of gluten-free dietary compliance. METHODS: Thirty-one pediatric patients (mean age 11.7±3.1 years) with biopsy-proven celiac disease and 40 pediatric patients as a control group were recruited in the study...
January 31, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28153477/at-risk-screened-children-with-celiac-disease-are-comparable-in-disease-severity-and-dietary-adherence-to-those-found-because-of-clinical-suspicion-a-large-cohort-study
#14
Laura Kivelä, Katri Kaukinen, Heini Huhtala, Marja-Leena Lähdeaho, Markku Mäki, Kalle Kurppa
OBJECTIVE: To assess whether children at risk for celiac disease should be screened systematically by comparing their baseline and follow-up characteristics to patients detected because of clinical suspicion. STUDY DESIGN: Five hundred four children with celiac disease were divided into screen-detected (n = 145) and clinically detected cohorts (n = 359). The groups were compared for clinical, serologic, and histologic characteristics and laboratory values...
January 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28152197/effect-of-salt-and-ethanol-addition-on-zein-starch-dough-and-bread-quality
#15
Brennan M Smith, Scott R Bean, Gordon Selling, David Sessa, Fadi M Aramouni
Development of viscoelastic doughs from non-wheat proteins allows for a wider range of gluten-free products. Little work has been completed to describe mechanisms of zein functionality in food systems. To identify factors responsible for dough development in zein-starch mixtures and their influence on zein bread quality, a mixture of 20% zein-80% maize starch was mixed with water and various reagents. Salts, NaSCN, NaCl, and Na2 SO4 were evaluated at concentrations from 0 to 2M for their influence on the properties of zein-starch dough systems...
February 2, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28146115/normal-bone-mineral-density-associates-with-duodenal-mucosa-healing-in-adult-patients-with-celiac-disease-on-a-gluten-free-diet
#16
Tiziana Larussa, Evelina Suraci, Maria Imeneo, Raffaella Marasco, Francesco Luzza
Impairment of bone mineral density (BMD) is frequent in celiac disease (CD) patients on a gluten-free diet (GFD). The normalization of intestinal mucosa is still difficult to predict. We aim to investigate the relationship between BMD and duodenal mucosa healing (DMH) in CD patients on a GFD. Sixty-four consecutive CD patients on a GFD were recruited. After a median period of a 6-year GFD (range 2-33 years), patients underwent repeat duodenal biopsy and dual-energy X-ray absorptiometry (DXA) scan. Twenty-four patients (38%) displayed normal and 40 (62%) low BMD, 47 (73%) DMH, and 17 (27%) duodenal mucosa lesions...
January 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28141922/assessment-of-avenins-from-different-oat-varieties-using-r5-based-sandwich-elisa
#17
Lora Benoit, Jongkit Masiri, Isabel A Del Blanco, Mahzad Meshgi, Steven M Gendel, Mansour Samadpour
Gluten derived from wheat and related triticeae cereals possesses distinct amino acid sequences that provoke the immunopathogenic features of celiac disease (CD) in genetically susceptible individuals. However, the role of oat-derived gluten, or avenins, in CD pathogenesis remains a disputed matter, as evidenced by a lack in harmonized legislation regarding gluten classification in relation to gluten-free labeling. In this study, we have analyzed a panel of pure oat cultivars using a sandwich ELISA based on the R5 monoclonal antibody (mAb), which binds to canonical epitopes occurring within celiagenic peptides present in triticeae-derived gluten but reportedly not present in avenins...
February 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28140462/physiopathology-and-management-of-gluten-induced-celiac-disease
#18
REVIEW
Jitendra Kumar, Manoj Kumar, Rajesh Pandey, Nar Singh Chauhan
Proline- and glutamine-rich gluten proteins are one of the major constituents of cereal dietary proteins, which are largely resistant to complete cleavage by the human gastrointestinal (GI) digestive enzymes. Partial digestion of gluten generates approximately 35 amino acids (aa) immunomodulatory peptides which activate T-cell-mediated immune system, followed by immunological inflammation of mucosa leading to the onset of celiac disease (CD). CD is an autoimmune disease associated with HLA-DQ2/DQ8 polymorphism and dysbiosis of gut microbiota...
January 31, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28140327/nonceliac-gluten-sensitivity
#19
REVIEW
Anna Krigel, Benjamin Lebwohl
Nonceliac gluten sensitivity (NCGS) refers to a clinical phenotype in which patients experience intestinal and extraintestinal symptoms related to ingesting a gluten-containing diet after a diagnosis of celiac disease (CD) or wheat allergy has been excluded. CD, an autoimmune disease characterized by villous atrophy triggered by the ingestion of gluten, has increased in prevalence in recent decades, although the majority of patients remain undiagnosed. There is now an increasing public awareness of NCGS and growing interest in the health effects of gluten among health professionals and the lay public...
November 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/28135975/a-diet-enriched-with-red-sorghum-flaked-biscuits-compared-to-a-diet-containing-white-wheat-flaked-biscuits-does-not-enhance-the-effectiveness-of-an-energy-restricted-meal-plan-in-overweight-and-mildly-obese-adults
#20
Anita Stefoska-Needham, Eleanor J Beck, Stuart K Johnson, Marijka J Batterham, Ross Grant, John Ashton, Linda C Tapsell
OBJECTIVES: Whole grain sorghum is a promising ingredient in foods, especially those targeting satiety and weight control. This study aimed to test weight loss effects of a whole grain red sorghum product incorporated into an energy-restricted diet. METHODS: Sixty subjects (46 females) were randomized to either a sorghum (intervention) or white wheat (control) group, receiving 45 g of flaked cereal biscuits to include daily in their prescribed diets for 12 weeks...
January 31, 2017: Journal of the American College of Nutrition
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