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https://www.readbyqxmd.com/read/28215999/rat-animal-models-for-screening-medications-to-treat-alcohol-use-disorders
#1
REVIEW
Richard L Bell, Sheketha R Hauser, Tiebing Liang, Youssef Sari, Antoinette Maldonado-Devincci, Zachary A Rodd
The purpose of this review is to present animal research models that can be used to screen and/or repurpose medications for the treatment of alcohol abuse and dependence. The focus will be on rats and in particular selectively bred rats. Brief introductions discuss various aspects of the clinical picture, which provide characteristics of individuals with alcohol use disorders (AUDs) to model in animals. Following this, multiple selectively bred rat lines will be described and evaluated in the context of animal models used to screen medications to treat AUDs...
February 16, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28214679/estradiol-is-a-critical-regulator-of-food-reward-behavior
#2
Jennifer E Richard, Lorena López-Ferreras, Rozita H Anderberg, Kajsa Olandersson, Karolina P Skibicka
Food intake is reduced by estrogenic hormones, levels of which vary throughout life and fluctuate throughout the ovarian cycle in females. However, estrogens have also been shown to increase reward derived from drugs of abuse, where motivational properties of drugs and progression to addiction are potentiated by estrogens. Whether reward derived from food, and specifically motivational properties of food, are altered by estrogens remains unknown. Here we investigated the effect of the estrous cycle on food reward behavior and show estrous cycle dictated variability in food motivation, measured by progressive ratio operant conditioning, in female rats...
January 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28196273/sex-and-adolescent-ethanol-exposure-influence-pavlovian-conditioned-approach
#3
Aric C Madayag, Sierra J Stringfield, Kathryn J Reissner, Charlotte A Boettiger, Donita L Robinson
BACKGROUND: Alcohol use among adolescents is widespread and a growing concern due to long-term behavioral deficits, including altered Pavlovian behavior, that potentially contribute to addiction vulnerability. We tested the hypothesis that adolescent intermittent ethanol (AIE) exposure alters Pavlovian behavior in males and females as measured by a shift from goal-tracking to sign-tracking. Additionally, we investigated GLT-1, an astrocytic glutamate transporter, as a potential contributor to a sign-tracking phenotype...
February 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28185706/training-induced-right-ventricular-remodelling-in-pre-adolescent-endurance-athletes-the-athlete-s-heart-in-children
#4
Flavio D'Ascenzi, Antonio Pelliccia, Francesca Valentini, Angela Malandrino, Benedetta Maria Natali, Riccardo Barbati, Marta Focardi, Marco Bonifazi, Sergio Mondillo
AIMS: Little is known about the adaptation of the right ventricle (RV) to endurance exercise in children. The aim of this study was to assess the effects of 5months of intensive training on RV morphology and function in preadolescent endurance athletes. METHODS: Ninety-four children were evaluated in this study. Fifty-seven male competitive swimmers (aged 10.8±0.2years) were evaluated before (baseline) and after 5months of the training (peak-training), and compared to 37 age- and sex-matched non-athlete children evaluated at baseline and after 5months of natural growth...
January 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28179811/sex-differences-in-addiction
#5
Jill B Becker
Women exhibit more rapid escalation from casual drug taking to addiction, exhibit a greater withdrawal response with abstinence, and tend to exhibit greater vulnerability than men in terms of treatment outcome. In rodents, short-term estradiol intake in female rats enhances acquisition and escalation of drug taking, motivation for drugs of abuse, and relapse-like behaviors. There is also a sex difference in the dopamine response in the nucleus accumbens. Ovariectomized female rats exhibit a smaller initial dopamine increase after cocaine treatment than castrated males...
December 2016: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28178893/sexually-transmitted-infection-prevalence-and-related-risk-factors-among-heterosexual-male-methamphetamine-users-in-china
#6
Dianchang Liu, Zhenxia Jiang, Cuizhen Xiu, Zhizhi Li, Qing Song, Zhenhong Wang
Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11.0. Among the 288 heterosexual male MA users, 51 (17.7%) had syphilis, 36 (12...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28170054/mobile-abuse-in-university-students-and-profiles-of-victimization-and-aggression
#7
Mª Isabel Polo Del Río, Santiago Mendo Lázaro, Benito León Del Barco, Elena Felipe Castaño
The vast majority of young people have mobile phones. This has become a must-have item in their lives, with traditional socialization spaces displaced by virtual ones. They use their mobile phones for many hours a day, to the detriment of their psychological and social functioning, showing greater vulnerability to abusive or excessive use, and more likely to become problematic or addicted users. This paper aims to study the impact of mobile phone abuse in a sample of college students, assessing the social, personal, and communicational realms and deepening understanding of the different cyberbullying profiles, analyzing who has more personal and social problems using mobiles: victims or aggressors...
January 12, 2017: Adicciones
https://www.readbyqxmd.com/read/28166486/drinking-motives-of-adult-patients-seeking-treatment-for-problematic-alcohol-use
#8
Anders Hammarberg, Caisa Öster, Christina Nehlin
INTRODUCTION: The Drinking Motives Questionnaire (DMQ) measures motives for alcohol consumption on four subscales. Coping with negative affect and enhancement of positive affect have been shown to be associated with high levels of alcohol consumption and alcohol-related problems. Few studies exist concerning drinking motives among treatment-seeking patients. The aims of the study were to investigate the factor structure of the shortened form of the revised DMQ (DMQ-R SF), map main drinking, explore group differences in motives due to sex, age, level of drinking problems and symptoms of depression/anxiety and to investigate whether different drinking motives predict alcohol-related problems in this group...
February 6, 2017: Journal of Addictive Diseases
https://www.readbyqxmd.com/read/28165486/alcohol-and-nicotine-codependence-associated-dna-methylation-changes-in-promoter-regions-of-addiction-related-genes
#9
Hongqin Xu, Fan Wang, Henry R Kranzler, Joel Gelernter, Huiping Zhang
Altered DNA methylation in addiction-related genes may modify the susceptibility to alcohol or drug dependence (AD or ND). We profiled peripheral blood DNA methylation levels of 384 CpGs in promoter regions of 82 addiction-related genes in 256 African Americans (AAs) (117 cases with AD-ND codependence and 139 controls) and 196 European Americans (103 cases with AD-ND codependence and 93 controls) using Illumina's GoldenGate DNA methylation array assays. AD-ND codependence-associated DNA methylation changes were analyzed using linear mixed-effects models with consideration of batch effects and covariates age, sex, and ancestry proportions...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28127624/oxycodone-self-administration-in-male-and-female-rats
#10
Maria Mavrikaki, Marco Pravetoni, Sarah Page, David Potter, Elena Chartoff
RATIONALE: Oxycodone is one of the most widely prescribed painkillers in the USA. However, its use is complicated by high abuse potential. As sex differences have been described in drug addiction, the present study tested for sex differences in intravenous oxycodone self-administration in rats. METHODS: Male and female Sprague-Dawley rats were implanted with jugular vein catheters and trained to self-administer oxycodone (0.03 mg/kg/infusion) under fixed ratio 1 (FR1), FR2, and FR5 schedules of reinforcement followed by a dose-response study to assess sensitivity to the reinforcing effects of oxycodone...
January 27, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28110822/oxytocin-acts-in-nucleus-accumbens-to-attenuate-methamphetamine-seeking-and-demand
#11
Brittney M Cox, Brandon S Bentzley, Helaina Regen-Tuero, Ronald E See, Carmela M Reichel, Gary Aston-Jones
BACKGROUND: Evidence indicates that oxytocin, an endogenous peptide well known for its role in social behaviors, childbirth, and lactation, is a promising addiction pharmacotherapy. We employed a within-session behavioral-economic (BE) procedure in rats to examine oxytocin as a pharmacotherapy for methamphetamine (meth) addiction. The BE paradigm was modeled after BE procedures used to assess motivation for drugs in humans with addiction. The same BE variables assessed across species have been shown to predict later relapse behavior...
December 1, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28095156/lung-cancer-risk-prediction-model-incorporating-lung-function-development-and-validation-in-the-uk-biobank-prospective-cohort-study
#12
David C Muller, Mattias Johansson, Paul Brennan
Purpose Several lung cancer risk prediction models have been developed, but none to date have assessed the predictive ability of lung function in a population-based cohort. We sought to develop and internally validate a model incorporating lung function using data from the UK Biobank prospective cohort study. Methods This analysis included 502,321 participants without a previous diagnosis of lung cancer, predominantly between 40 and 70 years of age. We used flexible parametric survival models to estimate the 2-year probability of lung cancer, accounting for the competing risk of death...
January 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28072417/dopaminergic-dynamics-underlying-sex-specific-cocaine-reward
#13
Erin S Calipari, Barbara Juarez, Carole Morel, Deena M Walker, Michael E Cahill, Efrain Ribeiro, Ciorana Roman-Ortiz, Charu Ramakrishnan, Karl Deisseroth, Ming-Hu Han, Eric J Nestler
Although both males and females become addicted to cocaine, females transition to addiction faster and experience greater difficulties remaining abstinent. We demonstrate an oestrous cycle-dependent mechanism controlling increased cocaine reward in females. During oestrus, ventral tegmental area (VTA) dopamine neuron activity is enhanced and drives post translational modifications at the dopamine transporter (DAT) to increase the ability of cocaine to inhibit its function, an effect mediated by estradiol. Female mice conditioned to associate cocaine with contextual cues during oestrus have enhanced mesolimbic responses to these cues in the absence of drug...
January 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28026981/challenges-to-practicing-hiv-sex-risk-prevention-among-people-in-continuing-care-for-cocaine-addiction
#14
Alexandra S Wimberly, Max R Stern, Sarah B Rosenbach, Tyrone Thomas, James R McKay
BACKGROUND: Intimate partnerships are discouraged during early recovery, despite research that highlights their capacity to be resources for change. OBJECTIVE: This study seeks to provide descriptions of intimate partnerships and how such partnerships challenge and/or support minimizing HIV sex-risk among participants in continuing care for cocaine addiction in order to inform substance use programming. METHODS: Forty-two recorded continuing care counseling sessions of 33 people who discussed HIV sex-risk behavior were transcribed and analyzed using thematic analysis...
December 27, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/28006783/altered-long-and-short-range-functional-connectivity-in-patients-with-betel-quid-dependence-a-resting-state-functional-mri-study
#15
Tao Liu, Jianjun Li, Zhiqiang Zhang, Qiang Xu, Guangming Lu, Shixiong Huang, Mengjie Pan, Feng Chen
OBJECTIVE: Addiction is a chronic relapsing brain disease. Brain structural abnormalities may constitute an abnormal neural network that underlies the risk of drug dependence. We hypothesized that individuals with Betel Quid Dependence (BQD) have functional connectivity alterations that can be described by long- and short-range functional connectivity density(FCD) maps. METHODS: We tested this hypothesis using functional magnetic resonance imaging (fMRI) data from subjects of the Han ethnic group in Hainan, China...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28001910/substance-use-health-and-functioning-characteristics-of-medical-marijuana-program-participants-compared-to-the-general-adult-population-in-ontario-canada
#16
Benedikt Fischer, Anca R Ialomiteanu, Samantha Aeby, Katherine Rudzinski, Paul Kurdyak, Jürgen Rehm
Existent profiles of Medical Marijuana Program (MMP) participants indicate common and co-morbid chronic diseases, yet evidence on disability or functioning as well as comparisons with general populations are largely lacking. This study compared health, substance use, and functioning status among formally approved MMP participants with the general adult population in Ontario (Canada). A community-recruited sample (n = 53) of MMP participants was compared to a sub-sample (n = 510) of the representative Centre for Addiction and Mental Health (CAMH) Monitor (2015 cycle) survey of Ontario general population adults (ages 18+) based on identical telephone-based interviews regarding substance use, health, and functioning measures...
January 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27991417/the-economic-burden-of-chronic-psychotic-disorders-in-ontario
#17
Claire de Oliveira, Joyce Cheng, Juergen Rehm, Paul Kurdyak
BACKGROUND: Chronic psychotic disorders are severe and disabling mental disorders associated with poor psychiatric and medical outcomes. These disorders are considered one of the most costly mental disorders due young age at onset and the need for intensive health care over the life course. AIMS OF THE STUDY: The purpose of this study was to estimate the direct health care costs of chronic psychotic disorders in Ontario in 2012 from the perspective of the third-party payer (i...
December 1, 2016: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/27988425/internet-addiction-disorder-personality-characteristics-and-risk-of-pathological-overuse-in-adolescents
#18
Donato Munno, Flora Cappellin, Marta Saroldi, Elisa Bechon, Fanny Guglielmucci, Roberto Passera, Giuseppina Zullo
AIM: Few studies have investigated Internet Addiction (IA) in adolescents in relation to personality characteristics. The aim of this study was to determine whether personality differences exist between adolescents with problematic/pathological Internet use and those with normal Internet use. Our hypothesis was that certain psychopathological personality traits may predispose to the development of maladaptive Internet use. METHODS: The Internet Addiction Test (IAT) and the Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) were administered to a sample of 224 high school students...
November 10, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27981195/sex-differences-in-subcellular-distribution-of-delta-opioid-receptors-in-the-rat-hippocampus-in-response-to-acute-and-chronic-stress
#19
Sanoara Mazid, Baila S Hall, Shannon C Odell, Khalifa Stafford, Andreina D Dyer, Tracey A Van Kempen, Jane Selegean, Bruce S McEwen, Elizabeth M Waters, Teresa A Milner
Drug addiction requires associative learning processes that critically involve hippocampal circuits, including the opioid system. We recently found that acute and chronic stress, important regulators of addictive processes, affect hippocampal opioid levels and mu opioid receptor trafficking in a sexually dimorphic manner. Here, we examined whether acute and chronic stress similarly alters the levels and trafficking of hippocampal delta opioid receptors (DORs). Immediately after acute immobilization stress (AIS) or one-day after chronic immobilization stress (CIS), the brains of adult female and male rats were perfusion-fixed with aldehydes...
December 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27940252/the-relationship-between-the-striatal-dopamine-transporter-and-novelty-seeking-and-cognitive-flexibility-in-opioid-dependence
#20
Chih-Sung Liang, Pei-Shen Ho, Che-Hung Yen, Chun-Yen Chen, Shin-Chang Kuo, Chang-Chih Huang, Yi-Wei Yeh, Kuo-Hsing Ma, San-Yuan Huang
Novelty seeking (NS) is a core personality trait that primes the susceptibility to drug addiction. Striatal dopamine activity contributes to cognitive flexibility, an important cognitive strategy to inhibit impulsivity and compulsive drug-seeking behavior. Evidence supports the association between dopamine and NS. Opioid-dependent patients show higher levels of NS, and repeated opioid exposure can cause cognitive deficits including poor cognitive flexibility and impaired impulse control. However, in opioid-dependent patients, the link between NS, striatal dopamine activity, and cognitive flexibility is still unclear...
March 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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