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https://www.readbyqxmd.com/read/29040067/early-onset-severe-obesity-due-to-complete-deletion-of-the-leptin-gene-in-a-boy
#1
Elif Ozsu, Serdar Ceylaner, Huseyin Onay
BACKGROUND: Monogenic obesity results from single gene mutations. Extreme obesity starting at an early age, especially in infancy, which is associated with endocrinopathy and metabolic disturbances is key to the diagnosis of monogenic obesity. CASE PRESENTATION: A 6-month-old boy was admitted to our clinic with severe obesity and food craving. He was born with a birth weight of 3400 g to first-cousin parents. He started to gain weight at an abnormal rate at the age of 2 months...
October 17, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29039297/the-impact-of-periconceptional-alcohol-exposure-on-fat-preference-and-gene-expression-in-the-mesolimbic-reward-pathway-in-adult-rat-offspring
#2
E S Dorey, C L Cullen, D Lucia, K M Mah, M-L Roy Manchadi, B S Muhlhausler, K M Moritz
Alcohol consumption around the time of conception is highly prevalent in Western countries. Exposure to ethanol levels during gestation has been associated with altered development of the mesolimbic reward pathway in rats and increased propensity to addiction, however the effect of exposure only around the time of conception is unknown. The current study investigated the effects of periconceptional alcohol exposure (PC:EtOH) on alcohol and palatable food preferences and gene expression in the ventral tegmental area (VTA) and the nucleus accumbens of the adult offspring...
October 17, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29039152/evaluation-of-the-neuropathic-pain-in-the-smokers
#3
Sercan Bulut Çelik, Hüseyin Can, Melih Kaan Sözmen, Tijen Şengezer, Yusuf Cem Kaplan, Gökçenur Utlu, Alp Şener, Arzu Aybek Yılmaz, Olgu Aygün
OBJECTIVES: Nicotine addiction is one of the most important causes of the general failure of treatment and keeping the habit of smoking. Peripheral neuropathy is a leading factor of smoking. This study aimed to analyze the association of neuropathic pain and addiction levels of individuals. METHODS: The study was performed on the day on which the smokers visited the hospital for any reason. The Douleur Neuropathique 4 (DN-4) Scale and Fagerström Addiction Survey were administered to the individuals after obtaining their consent...
July 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29038777/the-abcd-study-of-neurodevelopment-identifying-neurocircuit-targets-for-prevention-and-treatment-of-adolescent-substance-abuse
#4
James M Bjork, Lisa K Straub, Rosellen G Provost, Michael C Neale
Substance use disorders (SUD) can be considered developmental disorders in light of their frequent origins in substance initiation during adolescence. Cross-sectional functional magnetic resonance imaging (fMRI) studies of adolescent substance users or adolescents with SUD have indicated aberrations in brain structures or circuits implicated in motivation, self-control, and mood-regulation. However, attributing these differences to the neurotoxicological effects of chronic substance use has been problematic in that these circuits are also aberrant in at-risk children, such as those with prenatal substance exposure, externalizing disorders (such as conduct disorder), or prodromal internalizing disorders such as depression...
June 2017: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/29030249/sex-as-a-biological-variable-drug-use-and-abuse
#5
Anthony L Riley, Briana J Hempel, Matthew M Clasen
The study of sex as a biological variable is a necessary emphasis across a wide array of endpoints, including basic neuroscience, medicine, mental health, physiology and behavior. The present review summarizes work from clinical and preclinical populations on sex differences in drug use and abuse, ranging from initiation to escalation/dysregulation and from drug cessation/abstinence to relapse. These differences are analyzed in the context of the addiction cycle conceptualization of Koob and his colleagues and address patterns of drug use (binge/intoxication), motivation underlying its use (withdrawal/negative affect) and likelihood and causes of craving and relapse of drug taking (anticipation/preoccupation)...
October 10, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29030085/are-emotionally-driven-and-addictive-like-eating-behaviors-the-missing-links-between-psychological-distress-and-greater-body-weight
#6
L Bourdier, M Orri, A Carre, A N Gearhardt, L Romo, C Dantzer, S Berthoz
There is now a large body of evidence suggesting a significant association between emotional discomfort management, disordered eating behaviors and weight status. In the field of overweight and obesity, emotionally driven eating habits that resemble addictive behaviors are considered as a risk factor. This study aimed to investigate in a large sample of French university students 1) the associations between self-reported levels of psychological distress (PD), emotional eating (EE), food addiction (FA) and Body Mass Index (BMI); and 2) the potential mediation effect of eating behaviors (EE and FA) between PD and BMI...
October 10, 2017: Appetite
https://www.readbyqxmd.com/read/28985156/barriers-to-accessing-detox-facilities-substance-use-treatment-and-residential-services-among-women-impacted-by-commercial-sexual-exploitation-trafficking
#7
Lara B Gerassi
More than 50% of women entering substance use treatment in the U.S. reported having traded sex for money or drugs. Women's participation in addiction treatment and related services is essential to their recovery and increased safety, stabilization, and quality of life. This paper's aim is to explore the barriers related to accessing detox facilities and essential services including substance use treatment and residential services for women impacted by commercial sexual exploitation (CSE). Data are drawn from a larger, community-based, grounded theory study...
October 6, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28979752/triangular-relationship-among-risky-sexual-behavior-addiction-and-aggression-a-systematic-review
#8
REVIEW
Khodabakhsh Ahmadi, Seyed Alireza Javadinia, Seyed Hassan Saadat, Mohammad Arash Ramezani, Homa Sedghijalal
BACKGROUND: Risky sexual behavior (RSB), addiction, and aggression are three important personal and social factors which influence each other. OBJECTIVE: To overview the potential relationship among RSB, addiction, and aggression to conduct an interactive model for the pathology and management of human behavior. METHODS: This review article was carried out by searching studies in PubMed, Medline, Web of Science, Ebsco, IEEE, Scopus, Springer, MagIran, and IranMedex databases from the year 1993 to 2013...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28977525/oxytocin-reduces-cocaine-cued-fos-activation-in-a-regionally-specific-manner
#9
Kah-Chung Leong, Linnea R Freeman, Carole R Berini, Shannon M Ghee, Ronald E See, Carmela M Reichel
Background: Oxytocin may be a possible treatment for multiple neuropsychiatric disorders, including cocaine addiction. Little is known about the site-specific effects of oxytocin on various drug addiction-related brain regions. Furthermore, sexually dimorphic effects of oxytocin on neural function in the addiction circuit have not been established. Here, we studied Fos expression following cocaine-cued reinstatement in both male and female rats. Methods: Male and female rats underwent self-administration, extinction, and reinstatement tests...
October 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28974459/sex-differences-in-incentive-motivation-and-the-relationship-to-the-development-and-maintenance-of-alcohol-use-disorders
#10
Jacqueline M Barker, Jane R Taylor
Despite considerable evidence of higher rates of alcohol use disorders (AUDs) in men than in women, there is a dearth of research into the underlying causes of this disparity. As the gap in high risk drinking between men and women closes, it is critical to disentangle the biological factors that may place men and women at different risk for the development of AUDs as well as AUD-associated health problems. While sex differences in alcohol drinking have been reported in animal models and in human alcoholics, it increasingly seems that consummatory behavior may be dissociated from propensity toward inflexible and cue-elicited drug seeking and taking that characterize alcohol use disorders...
September 30, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28974404/influence-of-venus-and-mars-in-the-cognitive-sky-of-schizophrenia-results-from-the-first-step-national-face-sz-cohort
#11
G Fond, L Boyer, M Leboyer, O Godin, P M Llorca, M Andrianarisoa, F Berna, L Brunel, B Aouizerate, D Capdevielle, I Chereau, T D'Amato, C Dubertret, J Dubreucq, C Faget, F Gabayet, J Mallet, D Misdrahi, R Rey, C Lancon, C Passerieux, P Roux, P Vidailhet, H Yazbek, F Schürhoff, E Bulzacka
OBJECTIVES: Sex differences can yield important clues regarding illness pathophysiology and its treatment. Schizophrenia (SZ) has a lower incidence rate, and a better prognosis, in women versus men. The present study investigated the cognitive profiles of both sexes in a large multi-centre sample of community-dwelling SZ patients. METHOD: 544 community-dwelling stable SZ subjects (141 women and 403 men; mean age 34.5±12.1 and 31.6±8.7years, respectively) were tested with a comprehensive battery of neuropsychological tests...
September 30, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28969246/effect-of-ondansetron-on-prevention-of-ventilator-associated-pneumonia-in-intensive-care-unit-patients-in-kashani-hospital-in-2013
#12
Hossein Madineh, Omolbanin Rahimi, Mohamadreza Abedin Zadeh, Majid Kabiri
INTRODUCTION: Ventilator Associated Pneumonia (VAP) is the second most common infection with high mortality (24-50%). Ondansetron is a reliable and safe drug and it is currently used in the prevention of nausea and vomiting and has no side effects. AIM: The aim of the present study was to examine the effect of ondansetron on prevention of VAP in Intensive Care Unit (ICU) patients. MATERIALS AND METHODS: The present study was a randomized clinical trial study (IRCT201406156480N6), carried out at Kashani Hospital, Iran, in 2013 on 80 patients aged from 15-65 years...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28949432/the-use-of-crack-and-other-illicit-drugs-impacts-oral-health-related-quality-of-life-in-brazilians
#13
Raquel Pippi Antoniazzi, Fabricio Batistin Zanatta, Thiago Machado Ardenghi, Carlos Alberto Feldens
OBJECTIVE: The aim of the present study was to investigate the impact of the use of crack and other illicit drugs on oral health-related quality of life (OHRQoL) in young adults. METHODS: This cross-sectional study evaluated 106 crack users at a public treatment center for drug addiction and 106 controls matched for gender, age, and use of tobacco. Clinical examinations were performed for dental caries and periodontal disease. The outcome was OHRQoL, which was determined using the Oral Health Impact Profile (OHIP-14)...
September 26, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28948394/separating-models-obscures-the-scientific-underpinnings-of-sex-addiction-as-a-disorder
#14
Stefanie Carnes, Todd Love
No abstract text is available yet for this article.
September 25, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28946032/new-previously-unreported-correlations-between-latent-toxoplasma-gondii-infection-and-excessive-ethanol-consumption
#15
Dorota Samojłowicz, Aleksandra Borowska-Solonynko, Marcin Kruczyk
A number of world literature reports indicate that a latent Toxoplasma gondii infection leads to development of central nervous system disorders, which in turn may lead to altered behavior in the affected individuals. T. gondii infection has been observed to play the greatest role in drivers, suicides, and psychiatric patients. Studies conducted for this manuscript involve a different, never before really reported correlation between latent T. gondii infection and ethanol abuse. A total of 538 decedents with a known cause of death were included in the study...
September 18, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28942596/the-multidimensional-therapeutic-potential-of-targeting-the-brain-oxytocin-system-for-the-treatment-of-substance-use-disorders
#16
Michael T Bowen, Inga D Neumann
The neuropeptide oxytocin is released both into the blood and within the brain in response to reproductive stimuli, such as birth, suckling and sex, but also in response to social interaction and stressors. Substance use disorders, or addictions, are chronic, relapsing brain disorders and are one of the major causes of global burden of disease. Unfortunately, current treatment options for substance use disorders are extremely limited and a treatment breakthrough is sorely needed. There is mounting preclinical evidence that targeting the brain oxytocin system may provide that breakthrough...
September 24, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28941573/hypothalamic-pituitary-adrenal-axis-responsiveness-to-methamphetamine-is-modulated-by-gonadectomy-in-males
#17
Jason S Jacobskind, Zachary J Rosinger, Damian G Zuloaga
Sex differences in patterns of methamphetamine (MA) abuse have been reported with females (humans and rodents) showing an elevated addiction phenotype. Previous findings indicate MA-induced hypothalamic-pituitary-adrenal (HPA) axis activation is also sexually dimorphic with females exhibiting an elevated glucocorticoid release and differential neural activation patterns within HPA axis-associated brain regions. These effects may contribute to sex differences in abuse. To determine the role of gonadal hormones in mediating sex differences in MA-induced glucocorticoids, male and female C57BL/6J mice were gonadectomized or sham-operated, and following recovery, injected with MA (5 mg/kg) and sacrificed 60 minutes or 120 minutes later...
September 20, 2017: Brain Research
https://www.readbyqxmd.com/read/28893589/leptin-status-alters-buprenorphine-induced-antinociception-in-obese-mice-with-dysfunctional-leptin-receptors
#18
Zachary Glovak, Sara Mihalko, Helen A Baghdoyan, Ralph Lydic
Buprenorphine is an opiate used for pain management and to treat opiate addiction. The cytokine leptin can modulate nociception, but the extent to which buprenorphine-induced antinociception varies as a function of leptin signaling has not been characterized. Four congenic mouse lines with phenotypes that include differences in body weight and leptin status were used to test the hypothesis that the antinociceptive effects of buprenorphine vary as function of sex and leptin signaling. Each mouse line was comprised of males (n=12) and females (n=12) for a total of 96 animals...
September 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28888152/altered-functional-connectivity-to-stressful-stimuli-in-prenatally-cocaine-exposed-adolescents
#19
Yasmin Zakiniaeiz, Sarah W Yip, Iris M Balodis, Cheryl M Lacadie, Dustin Scheinost, R Todd Constable, Linda C Mayes, Rajita Sinha, Marc N Potenza
BACKGROUND: Prenatal cocaine exposure (PCE) is linked to addiction and obesity vulnerability. Neural responses to stressful and appetitive cues in adolescents with PCE versus those without have been differentially linked to substance-use initiation. However, no prior studies have assessed cue-reactivity responses among PCE adolescents using a connectivity-based approach. METHODS: Twenty-two PCE and 22 non-prenatally drug-exposed (NDE) age-, sex-, IQ- and BMI-matched adolescents participated in individualized guided imagery with appetitive (favorite-food), stressful and neutral-relaxing cue scripts during functional magnetic resonance imaging...
November 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28871491/robust-age-but-limited-sex-differences-in-mu-opioid-receptors-in-the-rat-brain-relevance-for-reward-and-drug-seeking-behaviors-in-juveniles
#20
Caroline J W Smith, Aarane M Ratnaseelan, Alexa H Veenema
In the brain, the µ-opioid receptor (MOR) is involved in reward-seeking behaviors and plays a pivotal role in the mediation of opioid use disorders. Furthermore, reward-seeking behaviors and susceptibility to opioid addiction are particularly evident during the juvenile period, with a higher incidence of opioid use in males and higher sensitivity to opioids in females. Despite these age and sex differences in MOR-mediated behaviors, little is known regarding potential age and sex differences in the expression of MORs in the brain...
September 4, 2017: Brain Structure & Function
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