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https://www.readbyqxmd.com/read/29045041/orbital-and-rotational-atherectomy-during-percutaneous-coronary-intervention-for-coronary-artery-calcification
#1
Michael S Lee, Jonathan S Gordin, Gregg W Stone, Samin K Sharma, Shigeru Saito, Ehtisham Mahmud, Jeff Chambers, Philippe Généreux, Richard Shlofmitz
Severe coronary artery calcification (CAC) increases the complexity of percutaneous coronary intervention (PCI) by inhibiting optimal stent expansion, leading to an increased risk of death, myocardial infarction, repeat revascularization, and stent thrombosis. Coronary atherectomy modifies and debulks calcified plaque to facilitate PCI. Although there is no clear consensus, and further studies are needed, the decision to perform atherectomy should be based upon the presence of fluoroscopic CAC or with the use of intravascular imaging...
October 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29036300/bayesian-hierarchical-modeling-based-on-multisource-exchangeability
#2
Alexander M Kaizer, Joseph S Koopmeiners, Brian P Hobbs
Bayesian hierarchical models produce shrinkage estimators that can be used as the basis for integrating supplementary data into the analysis of a primary data source. Established approaches should be considered limited, however, because posterior estimation either requires prespecification of a shrinkage weight for each source or relies on the data to inform a single parameter, which determines the extent of influence or shrinkage from all sources, risking considerable bias or minimal borrowing. We introduce multisource exchangeability models (MEMs), a general Bayesian approach for integrating multiple, potentially non-exchangeable, supplemental data sources into the analysis of a primary data source...
July 6, 2017: Biostatistics
https://www.readbyqxmd.com/read/29035075/whatever-you-do-don-t-look-at-the-evaluating-guidance-by-an-exclusionary-attentional-template
#3
Valerie M Beck, Steven J Luck, Andrew Hollingworth
People can use a target template consisting of one or more features to guide attention and gaze to matching objects in a search array. But can we also use feature information to guide attention away from known irrelevant items? Some studies found a benefit from foreknowledge of a distractor feature, whereas others found a cost. Importantly, previous work has largely relied on end-of-trial manual responses; it is unclear how feature-guided avoidance might unfold as candidate objects are inspected. In the current experiments, participants were cued with a distractor feature to avoid, then performed a visual search task while eye movements were recorded...
October 16, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29034313/newly-characterized-murine-undifferentiated-sarcoma-models-sensitive-to-virotherapy-with-oncolytic-hsv-1-m002
#4
Eric K Ring, Rong Li, Blake P Moore, Li Nan, Virginia M Kelly, Xiaosi Han, Elizabeth A Beierle, James M Markert, Jianmei W Leavenworth, G Yancey Gillespie, Gregory K Friedman
Despite advances in conventional chemotherapy, surgical techniques, and radiation, outcomes for patients with relapsed, refractory, or metastatic soft tissue sarcomas are dismal. Survivors often suffer from lasting morbidity from current treatments. New targeted therapies with less toxicity, such as those that harness the immune system, and immunocompetent murine sarcoma models to test these therapies are greatly needed. We characterized two new serendipitous murine models of undifferentiated sarcoma (SARC-28 and SARC-45) and tested their sensitivity to virotherapy with oncolytic herpes simplex virus 1 (HSV-1)...
December 15, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/29033314/analysis-of-threshold-stenosis-by-multiplanar-venogram-and%C3%A2-intravascular-ultrasound-examination-for-predicting-clinical-improvement-after-iliofemoral-vein-stenting-in-the%C3%A2-vidio-trial
#5
Paul J Gagne, Antonios Gasparis, Stephen Black, Patricia Thorpe, Marc Passman, Suresh Vedantham, William Marston, Mark Iafrati
BACKGROUND: Selecting patients for iliofemoral vein stenting has traditionally relied on the identification and quantification of stenotic lesions with imaging such as multiplanar venography. Recently, intravascular ultrasound (IVUS) imaging has become more available. However, to date, the usefulness of these imaging modalities using the customary >50% treatment threshold for diameter (multiplanar venography) and area (IVUS) stenosis of iliofemoral veins has not been validated prospectively within the context of clinical improvement...
October 12, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29032475/robot-assisted-and-conventional-freehand-pedicle-screw-placement-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Shutao Gao, Zhengtao Lv, Huang Fang
PURPOSE: Several studies have revealed that robot-assisted technique might improve the pedicle screw insertion accuracy, but owing to the limited sample sizes in the individual study reported up to now, whether or not robot-assisted technique is superior to conventional freehand technique is indefinite. Thus, we performed this systematic review and meta-analysis based on randomized controlled trials to assess which approach is better. METHODS: Electronic databases including PubMed, EMBASE, CENTRAL, ISI Web of Science, CNKI and WanFang were systematically searched to identify potentially eligible articles...
October 14, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29031285/evaluation-of-community-directed-operation-of-black-fly-traps-for-entomological-surveillance-of-onchocerca-volvulus-transmission-in-the-madi-mid-north-focus-of-onchocerciasis-in-northern-uganda
#7
Denis Loum, Charles R Katholi, Thomson Lakwo, Peace Habomugisha, Edridah M Tukahebwa, Thomas R Unnasch
Entomological measures of transmission are important metrics specified by the World Health Organization to document the suppression and interruption of transmission of Onchocerca volvulus, the causative agent of onchocerciasis. These metrics require testing of large numbers of vector black flies. Black fly collection has relied on human landing collections, which are inefficient and potentially hazardous. As the focus of the international community has shifted from onchocerciasis control to elimination, replacement of human landing collections has become a priority...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29029675/a-meta-analysis-of-compassion-based-interventions-current-state-of-knowledge-and-future-directions
#8
REVIEW
James N Kirby, Cassandra L Tellegen, Stanley R Steindl
OBJECTIVE: Scientific research into compassion has burgeoned over the past 20 years and interventions aiming to cultivate compassion towards self and others have been developed. This meta-analysis examined the effects of compassion-based interventions on a range of outcome measures. METHOD: Twenty-one randomized controlled trials (RCTs) from the last 12 years were included in the meta-analysis, with data from 1,285 participants analyzed. Effect sizes were standardized mean differences calculated using the difference in pre-post change in the treatment group and control group means, divided by the pooled pre-intervention standard deviation...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29027266/reliable-and-sensitive-physical-testing-of-elite-trapeze-sailors
#9
Jonathan Bay, Jens Bojsen-Møller, Nikolai B Nordsborg
It was investigated, if a newly developed discipline specific test for elite-level trapeze sailors is reli-able and sensitive. Furthermore, the physical demands of trapeze sailing were examined. In part 1, nine national team athletes were accustomed to a simulated sailing test, which subsequently was completed on four occasions to determine test reliability and sensitivity to manipulations in body-weight. Rope-pulling mean power output (MPO), oxygen consumption (VO2 ), heart rate (HR) and blood lactate values were acquired in all trials...
October 13, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29024916/can-monolinguals-be-like-bilinguals-evidence-from-dialect-switching
#10
Neil W Kirk, Vera Kempe, Kenneth C Scott-Brown, Andrea Philipp, Mathieu Declerck
Bilinguals rely on cognitive control mechanisms like selective activation and inhibition of lexical entries to prevent intrusions from the non-target language. We present cross-linguistic evidence that these mechanisms also operate in bidialectals. Thirty-two native German speakers who sometimes use the Öcher Platt dialect, and thirty-two native English speakers who sometimes use the Dundonian Scots dialect completed a dialect-switching task. Naming latencies were higher for switch than for non-switch trials, and lower for cognate compared to non-cognate nouns...
October 9, 2017: Cognition
https://www.readbyqxmd.com/read/29024670/a-meta-analysis-suggests-different-neural-correlates-for-implicit-and-explicit-learning
#11
Roman F Loonis, Scott L Brincat, Evan G Antzoulatos, Earl K Miller
A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after correct trials in the Saccade (implicit) task, a signature of explicit versus implicit learning. Likewise, error-related negativity, a marker for error processing, was greater in the Match (explicit) tasks...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29021919/safeguarding-the-future-of-independent-academic-clinical-cancer-research-in-europe-for-the-benefit-of-patients
#12
Anastassia Negrouk, Denis Lacombe, Fatima Cardoso, Franck Morin, Eva Carrasco, Joan Maurel, Rudolf Maibach, Enrique Aranda, Richard Marais, Rolf A Stahel
Cancer is a complex disease that is constantly evolving. It is now the most common cause of death in Europe after cardiovascular diseases. There are inequalities among European countries, potentially unsustainable healthcare systems impacting quality of cancer care and increasing number of patients with cancer with rare conditions. Clinical and translational research are the backbone in establishing scientific advances as novel treatments and advancing progress to the benefit of patients. Commercially sponsored clinical trials are responsible for developing new medicines that can treat various disease areas, including cancer...
2017: ESMO Open
https://www.readbyqxmd.com/read/29021746/lever-insertion-as-a-salient-stimulus-promoting-insensitivity-to-outcome-devaluation
#13
Youna Vandaele, Heather J Pribut, Patricia H Janak
Flexible and efficient decision-making in complex environments can be achieved through constant interactions between the goal-directed and habitual systems. While goal-directed behavior is considered dependent upon Response-Outcome (R-O) associations, habits instead rely on Stimulus-Response (S-R) associations. However, the stimuli that support the S-R association underlying habitual responding in typical instrumental procedures are poorly defined. To resolve this issue, we designed a discrete-trials procedure, in which rats must wait for lever insertion and complete a sequence of five lever presses to obtain a reward (20% sucrose or grain-based pellets)...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29020356/a-common-missense-variant-of-lilrb5-is-associated-with-statin-intolerance-and-myalgia
#14
Moneeza K Siddiqui, Cyrielle Maroteau, Abirami Veluchamy, Aleksi Tornio, Roger Tavendale, Fiona Carr, Ngu-Uma Abelega, Dan Carr, Katyrzyna Bloch, Par Hallberg, Qun-Ying Yue, Ewan R Pearson, Helen M Colhoun, Andrew D Morris, Eleanor Dow, Jacob George, Munir Pirmohamed, Paul M Ridker, Alex S F Doney, Ana Alfirevic, Mia Wadelius, Anke-Hilse Maitland-van der Zee, Daniel I Chasman, Colin N A Palmer
Aims: A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. We examined the association of this variant with statin intolerance ascertained from electronic medical records in the GoDARTS study...
August 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020353/differential-effects-of-pcsk9-variants-on-risk-of-coronary-disease-and-ischaemic-stroke
#15
Jemma C Hopewell, Rainer Malik, Elsa Valdés-Márquez, Bradford B Worrall, Rory Collins
Aims: PCSK9 genetic variants that have large effects on low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the development of therapeutic PCSK9-inhibition. However, there is limited evidence that PCSK9 variants are associated with ischaemic stroke (IS). Methods and results: Associations of the loss-of-function PCSK9 genetic variant (rs11591147; R46L), and five additional PCSK9 variants, with IS and IS subtypes (cardioembolic, large vessel, and small vessel) were estimated in a meta-analysis involving 10 307 IS cases and 19 326 controls of European ancestry...
July 17, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020232/staging-classification-of-aortic-stenosis-based-on-the-extent-of-cardiac-damage
#16
Philippe Généreux, Philippe Pibarot, Björn Redfors, Michael J Mack, Raj R Makkar, Wael A Jaber, Lars G Svensson, Samir Kapadia, E Murat Tuzcu, Vinod H Thourani, Vasilis Babaliaros, Howard C Herrmann, Wilson Y Szeto, David J Cohen, Brian R Lindman, Thomas McAndrew, Maria C Alu, Pamela S Douglas, Rebecca T Hahn, Susheel K Kodali, Craig R Smith, D Craig Miller, John G Webb, Martin B Leon
Aims: In patients with aortic stenosis (AS), risk stratification for aortic valve replacement (AVR) relies mainly on valve-related factors, symptoms and co-morbidities. We sought to evaluate the prognostic impact of a newly-defined staging classification characterizing the extent of extravalvular (extra-aortic valve) cardiac damage among patients with severe AS undergoing AVR. Methods and results: Patients with severe AS from the PARTNER 2 trials were pooled and classified according to the presence or absence of cardiac damage as detected by echocardiography prior to AVR: no extravalvular cardiac damage (Stage 0), left ventricular damage (Stage 1), left atrial or mitral valve damage (Stage 2), pulmonary vasculature or tricuspid valve damage (Stage 3), or right ventricular damage (Stage 4)...
July 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29019046/effect-of-reminding-patients-to-complete-fecal-immunochemical-testing-a-comparative-effectiveness-study-of-automated-and-live-approaches
#17
Gloria D Coronado, Jennifer S Rivelli, Morgan J Fuoco, William M Vollmer, Amanda F Petrik, Erin Keast, Sara Barker, Emily Topalanchik, Ricardo Jimenez
BACKGROUND: The Community Preventive Services Task Force recommends multi-component interventions, including patient reminders, to improve uptake of colorectal cancer screening. OBJECTIVE: We sought to compare the effectiveness of different forms of reminders for a direct-mail fecal immunochemical test (FIT) program. DESIGN: Patient-randomized controlled trial. PARTICIPANTS: 2772 adults aged 50-75, not up to date with colorectal cancer screening recommendations, with a clinic visit in the previous year at any of four participating health center clinics...
October 10, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29018195/prior-preferences-beneficially-influence-social-and-non-social-learning
#18
Tor Tarantola, Dharshan Kumaran, Peter Dayan, Benedetto De Martino
Our personal preferences affect a broad array of social behaviors. This includes the way we learn the preferences of others, an ability that often relies on limited or ambiguous information. Here we report an egocentric influence on this type of social learning that is reflected in both performance and response times. Using computational models that combine inter-trial learning and intra-trial choice, we find transient effects of participants' preferences on the learning process, through the influence of priors, and persistent effects on the choice process...
October 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29017427/fraction-intervention-for-students-with-mathematics-difficulties-lessons-learned-from-five-randomized-controlled-trials
#19
Lynn S Fuchs, Amelia S Malone, Robin F Schumacher, Jessica Namkung, Amber Wang
In this article, the authors summarize results from 5 randomized controlled trials assessing the effects of intervention to improve the fraction performance of fourth-grade students at risk for difficulty in learning about fractions. The authors begin by explaining the importance of competence with fractions and why an instructional focus on fractions magnitude understanding may improve learning. They then describe an intervention that relies strongly on this type of understanding about fractions instruction, and they provide an overview of the intervention's overall effects...
November 2017: Journal of Learning Disabilities
https://www.readbyqxmd.com/read/28989253/psidium-guajava-a-single-plant-for-multiple-health-problems-of-rural-indian-population
#20
REVIEW
Poonam G Daswani, Manasi S Gholkar, Tannaz J Birdi
The rural population in India faces a number of health problems and often has to rely on local remedies. Psidium guajava Linn. (guava), a tropical plant which is used as food and medicine can be used by rural communities due to its several medicinal properties. A literature search was undertaken to gauge the rural health scenario in India and compile the available literature on guava so as to reflect its usage in the treatment of multiple health conditions prevalent in rural communities. Towards this, electronic databases such as Pubmed, Science Direct, google scholar were scanned...
July 2017: Pharmacognosy Reviews
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