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https://www.readbyqxmd.com/read/30007359/loneliness-as-a-risk-factor-for-care-home-admission-in-the-english-longitudinal-study-of-ageing
#1
Barbara Hanratty, Daniel Stow, Danni Collingridge Moore, Nicole K Valtorta, Fiona Matthews
Background: loneliness has an adverse effect on health and well-being, and is common at older ages. Evidence that it is a risk factor for care home admission is sparse. Objective: to investigate the association between loneliness and care home admission. Setting: English Longitudinal Study of Ageing (ELSA). Participants: two-hundred fifty-four individuals across seven waves (2002-15) of ELSA who moved into care homes were age, sex matched to four randomly selected individuals who remained in the community...
July 10, 2018: Age and Ageing
https://www.readbyqxmd.com/read/30007318/socioeconomic-inequalities-in-psychosocial-problems-of-children-mediating-role-of-maternal-depressive-symptoms
#2
Sanne A A de Laat, Anja C Huizink, Michel H Hof, Tanja G M Vrijkotte
Background: Socioeconomically disadvantaged children often have psychosocial problems. This study examined the mediating role of maternal depressive symptoms during pregnancy, infancy and early childhood in the association between maternal education, as indicator of socioeconomic status (SES), and child's psychosocial problems. Methods: Included were 3410 children from the Amsterdam Born Children and their Development (ABCD) study. To assess the child's psychosocial problems at age 5-6 years, mothers and teachers completed the Strengths and Difficulties Questionnaire (SDQ)...
July 10, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/30007308/steps-an-efficient-prospective-likelihood-approach-to-genetic-association-analyses-of-secondary-traits-in-extreme-phenotype-sequencing
#3
Wenjian Bi, Yun Li, Matthew P Smeltzer, Guimin Gao, Shengli Zhao, Guolian Kang
It has been well acknowledged that methods for secondary trait (ST) association analyses under a case-control design (ST$_{\text{CC}}$) should carefully consider the sampling process to avoid biased risk estimates. A similar situation also exists in the extreme phenotype sequencing (EPS) designs, which is to select subjects with extreme values of continuous primary phenotype for sequencing. EPS designs are commonly used in modern epidemiological and clinical studies such as the well-known National Heart, Lung, and Blood Institute Exome Sequencing Project...
July 11, 2018: Biostatistics
https://www.readbyqxmd.com/read/30006959/optimal-search-strategies-for-identifying-moderators-and-predictors-of-treatment-effects-in-pubmed
#4
Marcia Tummers, Ralph van Hoorn, Charlotte Levering, Andrew Booth, Gert Jan van der Wilt, Wietske Kievit
BACKGROUND: Treatment effects differ across patients. To guide selection of treatments for patients, it is essential to acknowledge these differences and identify moderators or predictors. Our aim was to generate optimal search strategies (commonly known as filters) for PubMed to retrieve papers identifying moderators and predictors of treatment effects. METHODS: Six journals were hand-searched for articles on moderators or predictors. Selected articles were randomly allocated to a development and validation set...
July 13, 2018: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/30006808/exploring-tumourigenic-potential-of-the-parasite-anisakis-a-pilot-study
#5
María Teresa Corcuera, Cruz Rodríguez-Bobada, Jaime Zuloaga, Fernando Gómez-Aguado, Rosa Rodríguez-Perez, Ángel Mendizabal, Pablo González, Javier Arias-Díaz, María Luisa Caballero
Anisakiasis is a global disease caused by consumption of raw or lightly cooked fish parasitised with Anisakis spp. third-stage larvae. Cases in the literature show colocalised anisakiasis and colorectal cancer, and the incidental finding of Anisakis larvae at the tumour site was reported. Data from our group suggested an epidemiological link between previous infection and gastrointestinal cancer. Furthermore, it has recently been reported that Anisakis products lead to inflammation and DNA damage. Based on these facts, the aim was to investigate whether Anisakis antigens are able to induce changes in the proliferation of epithelial cells in vitro or in the expression of serum microRNA (miRNA) in Sprague-Dawley rats...
July 13, 2018: Parasitology Research
https://www.readbyqxmd.com/read/30006743/-seasonal-variation-in-surgical-diseases-is-an-economic-resource-management-necessary
#6
N Eisenberg, I Gockel, N von Dercks
BACKGROUND: The registration of diagnoses and diagnose-related groups (DRG) allows conclusions to be drawn about the distribution over the course of the year. Seasonal variations can be recognized and used to plan further resource management. METHODS: From 2006 to 2016 a total of 30,999 main diagnoses and DRGs were registered at the hospital for visceral surgery of the University Medical Hospital in Leipzig. The data were sorted on a monthly and seasonal basis and compared to meteorological data received from the German Meteorological Service...
July 13, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/30006589/population-genomics-of-hypervirulent-klebsiella-pneumoniae-clonal-group-23-reveals-early-emergence-and-rapid-global-dissemination
#7
Margaret M C Lam, Kelly L Wyres, Sebastian Duchêne, Ryan R Wick, Louise M Judd, Yunn-Hwen Gan, Chu-Han Hoh, Sophia Archuleta, James S Molton, Shirin Kalimuddin, Tse Hsien Koh, Virginie Passet, Sylvain Brisse, Kathryn E Holt
Severe liver abscess infections caused by hypervirulent clonal-group CG23 Klebsiella pneumoniae have been increasingly reported since the mid-1980s. Strains typically possess several virulence factors including an integrative, conjugative element ICEKp encoding the siderophore yersiniabactin and genotoxin colibactin. Here we investigate CG23's evolutionary history, showing several deep-branching sublineages associated with distinct ICEKp acquisitions. Over 80% of liver abscess isolates belong to sublineage CG23-I, which emerged in ~1928 following acquisition of ICEKp10 (encoding yersiniabactin and colibactin), and then disseminated globally within the human population...
July 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/30006493/endothelial-microparticles-and-systemic-complement-activation-in-patients-with-chronic-kidney-disease
#8
Diana Jalal, Brandon Renner, Jennifer Laskowski, Erik Stites, James Cooper, Karissa Valente, Zhiying You, Loni Perrenoud, Moglie Le Quintrec, Ismaeel Muhamed, Uwe Christians, Jelena Klawitter, Margaret A Lindorfer, Ronald P Taylor, V Michael Holers, Joshua M Thurman
BACKGROUND: Endothelial microparticles are associated with chronic kidney disease (CKD) and complement activation. We hypothesized that the complement pathway is activated in patients with CKD via endothelial microparticles and that complement activation correlates with endothelial dysfunction in CKD. METHODS AND RESULTS: We analyzed complement data of 30 healthy subjects, 30 patients with stage III/IV CKD, and 30 renal transplant recipients with stage III/IV CKD, evaluating the potential correlation of complement fragments with brachial artery flow-mediated dilation, Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate, and urinary albumin/creatinine ratio...
July 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30006394/prevalence-and-genotyping-of-cryptosporidium-species-in-sheep-in-china
#9
Rongsheng Mi, Xiaojuan Wang, Yan Huang, Guodong Mu, Yehua Zhang, Haiyan Jia, Xiaoli Zhang, Heng Yang, Xu Wang, Xiangan Han, Zhaoguo Chen
In this study, we assessed the prevalence and genetic characteristics of Cryptosporidium in sheep from 10 provinces in China. Faecal samples from 1035 sheep originating from 16 farms were collected and 295 (28.5%) were found to be Cryptosporidium positive by nested PCR. Cryptosporidium was detected at all farms, with infection rates between 5.7% and 50.0%. Three Cryptosporidium species were identified, including Cryptosporidium xiaoi (73.2%, 216/295), Cryptosporidium ubiquitum (21.7%, 64/295), and Cryptosporidium parvum (5...
July 13, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/30006341/thyroid-function-disruptors-from-nature-to-chemicals
#10
Karen J Oliveira, Maria Izabel Chiamolera, Gisele Giannocco, Carmen Cabanelas Pazos-Moura, Tania Maria Ortiga-Carvalho
The modern concept of thyroid disruptors includes man-made chemicals and bioactive compounds from food that interfere with any aspect of the hypothalamus-pituitary-thyroid axis, thyroid hormone biosynthesis and secretion, blood and transmembrane transport, metabolism and local action of thyroid hormones. This review highlights relevant disruptors that effect populations through their diet: directly from food itself (fish oil and polyunsaturated fatty acids, pepper, coffee, cinnamon and resveratrol/grapes), through vegetable cultivation (pesticides) and from containers for food storage and cooking (bisphenol A, phthalates and polybrominated diphenyl ethers)...
July 13, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/30006327/effectiveness-of-a-blended-care-self-management-program-for-caregivers-of-people-with-early-stage-dementia-partner-in-balance-randomized-controlled-trial
#11
Lizzy Mm Boots, Marjolein E de Vugt, Gertrudis Ijm Kempen, Frans Rj Verhey
BACKGROUND: The benefits of electronic health support for dementia caregivers are increasingly recognized. Reaching caregivers of people with early-stage dementia could prevent high levels of burden and psychological problems in the later stages. OBJECTIVE: The current study evaluates the effectiveness of the blended care self-management program, Partner in Balance, compared to a control group. METHODS: A single-blind randomized controlled trial with 81 family caregivers of community-dwelling people with mild dementia was conducted...
July 13, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/30006322/lipoprotein-a-levels-and-outcomes-in-stable-outpatients-with-symptomatic-artery-disease
#12
Juan F Sanchez Muñoz-Torrero, Sergio Rico-Martín, Lorenzo Ramón Álvarez, Eduardo Aguilar, José Nicolás Alcalá, Manuel Monreal
BACKGROUND AND AIMS: Although genetic and epidemiological studies support that people with high lipoprotein (a) [Lp(a)] levels are at an increased risk for arterial disease, its prognostic value in patients with established artery disease has not been consistently evaluated. METHODS: FRENA is a prospective registry of consecutive outpatients with coronary, cerebrovascular or peripheral artery disease. We assessed the risk for subsequent myocardial infarction, ischemic stroke or limb amputation according to Lp(a) levels at baseline...
July 4, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30006046/population-structure-of-pseudomonas-aeruginosa-through-a-mlst-approach-and-antibiotic-resistance-profiling-of-a-mexican-clinical-collection
#13
F J Castañeda-Montes, M Avitia, O Sepúlveda-Robles, V Cruz-Sánchez, L Kameyama, G Guarneros, A E Escalante
Pseudomonas aeruginosa is one of the most important pathogens worldwide. Population genetics studies have shown that the P. aeruginosa population has an epidemic structure with highly conserved clonal complexes. Nonetheless, epidemiological studies of P. aeruginosa have been historically absent or infrequent in developing countries, in which different medical treatments, conditions and infrastructure may have an impact in population dynamics and evolutionary outcomes, including antibiotic resistance profiles...
July 10, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/30006029/causative-agents-and-antimicrobial-resistance-patterns-of-human-skin-and-soft-tissue-infections-in-bagamoyo-tanzania
#14
Theckla Kazimoto, Salim Abdulla, Leah Bategereza, Omar Juma, Francis Mhimbira, Maja Weisser, Jürg Utzinger, Lutz von Müller, Sören L Becker
Few epidemiological studies have been carried out to assess the aetiology and antimicrobial susceptibility patterns of pathogens giving rise to skin and soft tissue infections (SSTIs) in sub-Saharan Africa. In the present study from six healthcare facilities in Bagamoyo, Tanzania, wound swabs from outpatients with SSTIs were analysed by a suite of methods, including microbiological culture techniques, matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and resistance testing. Among 185 patients with SSTIs, 179 (97%) swabs showed microbiological growth...
July 10, 2018: Acta Tropica
https://www.readbyqxmd.com/read/30005967/factors-associated-with-wound-and-implant-related-complications-after-surgical-treatment-of-ankle-fractures
#15
Diederik P J Smeeing, Jan P Briet, Charlotte S van Kessel, Michiel M Segers, Egbert J Verleisdonk, Luke P H Leenen, Roderick M Houwert, Falco Hietbrink
We have described the epidemiology of complications after surgical treatment of ankle fractures and assessed which factors are associated with the most frequent complications. We conducted a retrospective cohort study at 2 level 2 and 1 level 1 trauma center in a single trauma region in the Netherlands. The study variables were collected from the electronic medical patient records; all ankle fractures were classified using the Lauge-Hansen classification, and the complications were recorded. A total of 989 patients were included from 3 hospitals, with 173 complications in 156 patients (15...
July 10, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/30005930/occurrence-antimicrobial-resistance-and-whole-genome-sequencing-analysis-of-salmonella-isolates-from-chicken-carcasses-imported-into-iraq-from-four-different-countries
#16
Ali Harb, Ihab Habib, Ezat Hussain Mezal, Hayder Shannoon Kareem, Tanya Laird, Mark O'Dea, Sam Abraham
Salmonella is a major cause of human foodborne illnesses worldwide; however, little is known about its occurrence and genomic characteristics in food sources in many developing countries. This study investigates the occurrence, serotypes distribution, antimicrobial resistance, and multilocus sequence types (ST) of Salmonella isolated from 400 imported frozen chicken carcasses sold in the markets of Thi-Qar, south-eastern Iraq. Salmonella was detected in 46 out of 400 tested samples [11.5% (95% confidence interval: 8...
July 5, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/30005880/infratemporal-fossa-tumors-when-to-suspect-a-malignant-tumor-a-retrospective-cohort-study-of-62-cases
#17
Q Lisan, N Leclerc, R Kania, J-P Guichard, P Herman, B Verillaud
OBJECTIVES: Infratemporal fossa (ITF) tumors are rare and little is known about their general epidemiology, making it sometimes difficult for clinicians, who seldom encounter them, to distinguish between benign and malignant forms on the basis of the initial clinical and radiological work-up alone. The objectives of this retrospective study were: (i) to determine the respective prevalences of the various histologic types of ITF tumor, and (ii) to assess associations between certain clinical and radiological features and malignancy...
July 10, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/30005759/critical-analysis-of-markov-models-used-for-the-economic-evaluation-of-colorectal-cancer-screening-a-systematic-review
#18
REVIEW
Nicolas Silva-Illanes, Manuel Espinoza
BACKGROUND: The economic evaluation of colorectal cancer screening is challenging because of the need to model the underlying unobservable natural history of the disease. OBJECTIVES: To describe the available Markov models and to critically analyze their main structural assumptions. METHODS: A systematic search was performed in eight relevant databases (MEDLINE, Embase, Econlit, National Health Service Economic Evaluation Database, Health Economic Evaluations Database, Health Technology Assessment database, Cost-Effective Analysis Registry, and European Network of Health Economics Evaluation Databases), identifying 34 models that met the inclusion criteria...
July 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/30005732/the-effect-of-abnormal-vitamin-d-levels-in-athletes
#19
REVIEW
Jakub Sikora-Klak, Steven J Narvy, Justin Yang, Eric Makhni, F Daniel Kharrazi, Nima Mehran
Vitamin D is a lipophilic prohormone integral to musculoskeletal, autoimmune, oncologic, cardiovascular, and mental health. Of particular importance to the orthopedic surgeon is the role of vitamin D in the regulation of bone mass, muscle strength, and physical performance. Although vitamin D-related skeletal pathologies are rare in industrialized nations, emerging research in the field has shown that most American adults have inadequate levels of vitamin D. Even among athletes, there is a high prevalence of vitamin D deficiency, which may place competitors at risk of stress fractures, illness, and delayed muscle recovery...
July 5, 2018: Permanente Journal
https://www.readbyqxmd.com/read/30005653/epidemiology-and-ecology-of-west-nile-virus-in-sub-saharan-africa
#20
REVIEW
Waidi F Sule, Daniel O Oluwayelu, Luis M Hernández-Triana, Anthony R Fooks, Marietjie Venter, Nicholas Johnson
West Nile virus (WNV) is the aetiological agent of the mosquito-borne zoonotic disease West Nile fever. The virus, first isolated in Uganda in 1937, evolved into two distinct lineages in sub-Saharan Africa (SSA) that subsequently spread to most continents where the virus has evolved further as evident through phylogenetic analysis of extant genomes. Numerous published reports from the past 70 years from countries in SSA indicate that the virus is endemic across the region. However, due in part to the limited availability of diagnostic methods across large areas of the continent, the human burden of WNV is poorly understood...
July 13, 2018: Parasites & Vectors
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