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https://www.readbyqxmd.com/read/28339287/rapid-radiologic-progression-of-silicosis
#1
Kazuo Tsuchiya, Mikio Toyoshima, Norimichi Akiyama, Masato Kono, Yutaro Nakamura, Kazuhito Funai, Satoshi Baba, Haruhiko Sugimura, Hitomi Kanayama, Takafumi Suda
No abstract text is available yet for this article.
March 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28317464/molecular-mechanisms-of-pulmonary-response-progression-in-crystalline-silica-exposed-rats
#2
Rajendran Sellamuthu, Christina Umbright, Jenny R Roberts, Shih-Houng Young, Diana Richardson, Walter McKinney, Bean T Chen, Shengqiao Li, Michael Kashon, Pius Joseph
An understanding of the mechanisms underlying diseases is critical for their prevention. Excessive exposure to crystalline silica is a risk factor for silicosis, a potentially fatal pulmonary disease. Male Fischer 344 rats were exposed by inhalation to crystalline silica (15 mg/m(3), six hours/day, five days) and pulmonary response was determined at 44 weeks following termination of silica exposure. Additionally, global gene expression profiling in lungs and BAL cells and bioinformatic analysis of the gene expression data were done to understand the molecular mechanisms underlying the progression of pulmonary response to silica...
March 19, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28300665/grape-seed-extract-ameliorates-bleomycin-induced-mouse-pulmonary-fibrosis
#3
Qi Liu, Jun-Xia Jiang, Ya-Nan Liu, Yan Guan, Wei Zhao, Yong-Liang Jia, Xin-Wei Dong, Yun Sun, Qiang-Min Xie
Pulmonary fibrosis is common in a variety of inflammatory lung diseases, such as interstitial pneumonia, chronic obstructive pulmonary disease, and silicosis. There is currently no effective clinical drug treatment. It has been reported that grape seed extracts (GSE) has extensive pharmacological effects with minimal toxicity. Although it has been found that GSE can improve the lung collagen deposition and fibrosis pathology induced by bleomycin in rat, its effects on pulmonary function, inflammation, growth factors, matrix metalloproteinases and epithelial-mesenchymal transition remain to be researched...
March 11, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28299449/contribution-of-job-exposure-matrices-for-exposure-assessment-in-occupational-safety-and-health-monitoring-systems-application-from-the-french-national-occupational-disease-surveillance-and-prevention-network
#4
Arnaud Florentin, Denis Zmirou-Navier, Christophe Paris
OBJECTIVES: To detect new hazards ("signals"), occupational health monitoring systems mostly rest on the description of exposures in the jobs held and on reports by medical doctors; these are subject to declarative bias. Our study aims to assess whether job-exposure matrices (JEMs) could be useful tools for signal detection by improving exposure reporting. METHODS: Using the French national occupational disease surveillance and prevention network (RNV3P) data from 2001 to 2011, we explored the associations between disease and exposure prevalence for 3 well-known pathology/exposure couples and for one debatable couple...
March 16, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28285600/experimental-silicosis-does-not-aggravate-collagen-induced-arthritis-in-mice
#5
Robby Engelmann, Brigitte Müller-Hilke
OBJECTIVES: To investigate the effect of chronic lung inflammation on the incidence and severity of collagen-induced arthritis in mice. METHODS: Chronic lung inflammation in the form of silicosis was induced via intranasal application of silica particles. Immunization with collagen Type II commenced one week later and mice were sacrificed six weeks after booster immunization. Thereafter, silicosis was confirmed via flow cytometry and arthritis was evaluated performing knee and paw histology...
March 13, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28277537/bbc3-in-macrophages-promoted-pulmonary-fibrosis-development-through-inducing-autophagy-during-silicosis
#6
Haijun Liu, Yusi Cheng, Jian Yang, Wei Wang, Shencun Fang, Wei Zhang, Bing Han, Zewei Zhou, Honghong Yao, Jie Chao, Hong Liao
Following inhalation into the lungs, silica particles are engulfed by alveolar macrophages, which triggers endogenous or exogenous apoptosis signaling pathways. As an inducer of apoptosis, the role of BBC3/PUMA (BCL2-binding component 3) in macrophages during silicosis remains unknown. Here, we exposed U937 cell-derived macrophages (UDMs) to SiO2 in vitro to explore the function of BBC3 in SiO2-induced disease. We found that SiO2 induced increased BBC3 expression, as well as macrophage activation and apoptosis...
March 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28243231/il-10-producing-cd1d-hi-cd5-regulatory-b-cells-may-play-a-critical-role-in-modulating-immune-homeostasis-in-silicosis-patients
#7
Ying Chen, Chao Li, Yiping Lu, Huiying Zhuang, Weijia Gu, Bo Liu, Fangwei Liu, Jinkai Sun, Bo Yan, Dong Weng, Jie Chen
Silicosis is characterized by chronic lung inflammation and fibrosis, which are extremely harmful to human health. The pathogenesis of silicosis involves uncontrolled immune processes. Evidence supports that regulatory B cells (Bregs) produce negative regulatory cytokines, such as IL-10, which can negatively regulate immune responses in inflammation and autoimmune diseases. Our previous study found that IL-10-producing B cells were involved in the development of silica-induced lung inflammation and fibrosis of mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28222740/dibutyryl-camp-attenuates-pulmonary-fibrosis-by-blocking-myofibroblast-differentiation-via-pka-creb-cbp-signaling-in-rats-with-silicosis
#8
Yan Liu, Hong Xu, Yucong Geng, Dingjie Xu, Lijuan Zhang, Yi Yang, Zhongqiu Wei, Bonan Zhang, Shifeng Li, Xuemin Gao, Ruimin Wang, Xianghong Zhang, Darrell Brann, Fang Yang
BACKGROUND: Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by silica. METHODS: A HOPE MED 8050 exposure control apparatus was used to create the silicosis model. Rats were randomly divided into 4 groups: 1)controls for 16 w; 2)silicosis for 16 w; 3)db-cAMP pre-treatment; 4) db-cAMP post-treatment...
February 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28217139/characterizing-particle-size-distributions-of-crystalline-silica-in-gold-mine-dust
#9
Lauren G Chubb, Emanuele G Cauda
Dust containing crystalline silica is common in mining environments in the U.S. and around the world. The exposure to respirable crystalline silica remains an important occupational issue and it can lead to the development of silicosis and other respiratory diseases. Little has been done with regard to the characterization of the crystalline silica content of specific particle sizes of mine-generated dust. Such characterization could improve monitoring techniques and control technologies for crystalline silica, decreasing worker exposure to silica and preventing future incidence of silicosis...
January 2017: Aerosol and Air Quality Research
https://www.readbyqxmd.com/read/28209773/mannan-binding-lectin-a-serum-collectin-suppresses-t-cell-proliferation-via-direct-interaction-with-cell-surface-calreticulin-and-inhibition-of-proximal-t-cell-receptor-signaling
#10
Na Zhao, Jie Wu, Simin Xiong, Liyun Zhang, Xiao Lu, Shangliang Chen, Qifeng Wu, Hailan Wang, Ying Liu, Zhengliang Chen, Daming Zuo
Mannan binding lectin (MBL), initially described to activate the complement pathway, is also known to be involved in the pathogenesis of autoimmune diseases. We report a thus far unknown function of MBL as a suppressor of T-cell activation. MBL markedly inhibited T-cell proliferation induced by anti-CD3 and anti-CD28 antibodies. Moreover, the presence of MBL during T-cell priming interfered with proximal T-cell receptor signaling by decreasing phosphorylation of Lck, ZAP-70, and LAT. MBL bound to T cells through interaction between the collagen-like region of MBL and calreticulin (CRT) expressed on the T-cell surface...
February 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28195659/silica-exposure-and-disease-in-semi-precious-stone-craftsmen-minas-gerais-brazil
#11
Ana Paula S Carneiro, Nayara F T Braz, Eduardo Algranti, Olivia M P A Bezerra, Natália P S Araujo, Lênio S Amaral Eng Hyg, Jean L Edmé, Annie Sobaszek, Nathalie Chérot-Kornobis
BACKGROUND: Brazil is an exporter of precious stones and craftsmen often work in poor conditions. We assessed silica-related diseases among crystal craftsmen and the complexity of its control. METHODS: Case-series including 118 subjects evaluated from 2006 to 2015, based on medical interviews, chest X-rays, spirometry, and respirable silica samples. RESULTS: Median age and length of exposure were 32 and 13 years, respectively. Silicosis, with 1/0 as a threshold, was diagnosed radiologically in 57 individuals (48...
March 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28194086/silicosis-in-the-form-of-progressive-massive-fibrosis-a-diagnostic-challenge
#12
Somnath Bhattacharya, Atin Dey, Amitava Pal, Saurav Kar, Sayantan Saha
Silicosis is a major occupational lung disease with a relatively fatal and irreversible outcome. Early diagnosis for shifting the potential candidates to safe modes of workplace as well as for prevention of further progression is the cornerstone of management. Here, we present a complicated case of silicosis in the form of progressive massive fibrosis, which was initially interpreted as tuberculosis; radiological images had resemblance with tuberculosis and cryptogenic organizing pneumonia. Radiology-guided trucut biopsy was imperative to confirm the diagnosis...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28177948/silicosis-and-autoimmunity
#13
Suni Lee, Hiroaki Hayashi, Hidenori Mastuzaki, Naoko Kumagai-Takei, Takemi Otsuki
PURPOSE OF REVIEW: Of the various environmental, occupational, and medical substances that cause dysregulation of autoimmunity, the effects and causative mechanisms of silica particles and asbestos fibers are discussed in this review. RECENT FINDINGS: With respect to silica, many epidemiological studies have shown a significant association between silica exposure and the occurrence of autoimmune diseases. Although the importance of the NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome as the initial immune reaction against silica particles has been identified, the mechanisms involved that lead to various autoimmune diseases in patients exposed to silica remain largely unknown...
April 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28166128/commentary-for-joem-forum-silicosis-then-and-now
#14
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28145560/survival-following-lung-transplantation-for-artificial-stone-silicosis-relative-to-idiopathic-pulmonary-fibrosis
#15
Dror Rosengarten, Benjamin D Fox, Elizabeth Fireman, Paul D Blanc, Victoria Rusanov, Oren Fruchter, Yael Raviv, Osnat Shtraichman, Milton Saute, Mordechai R Kramer
BACKGROUND: Silicosis is a progressive lung disease resulting from the inhalation of respirable crystalline silica. Lung transplantation is the only treatment for end-stage silicosis. The aim of this study was to analyze the survival experience following lung transplantation among patients with silicosis. METHODS: We reviewed data for all patients who underwent lung transplantation for silicosis and a matched group undergoing lung transplantation for idiopathic pulmonary fibrosis (IPF) at a single medical center between March 2006 and the end of December 2013...
February 1, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28139521/association-between-genetic-variants-of-transforming-growth-factor-%C3%AE-1-and-susceptibility-of-pneumoconiosis-a-meta-analysis
#16
Chang-Wen Deng, Xing-Xing Zhang, Jin-Huan Lin, Li-Fei Huang, Yu-Lan Qu, Chong Bai
BACKGROUND: Transforming growth factor-beta 1 (TGF-β1) and gene variants have been extensively studied in various human diseases. For example, TGF-β1 polymorphisms were associated with fibrosis and pneumoconiosis, but the data remained controversial. The aim of this meta-analysis was to assess the association between TGF-β1 -509 C>T [rs1800469], +869 T>C [rs1800470], and +915 G>C [rs1800471] polymorphisms and pneumoconiosis. METHODS: A comprehensive literature search was conducted through searching in PubMed, Embase, the Chinese Biomedical Database, and the Wei Pu (Chinese) Database by the end of April 2016...
February 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28088237/association-between-diabetes-mellitus-and-multi-drug-resistant-tuberculosis-a-protocol-for-a-systematic-review-and-meta-analysis
#17
Balewgizie Sileshi Tegegne, Tesfa Dejenie Habtewold, Melkamu Merid Mengesha, Johannes G M Burgerhof
INTRODUCTION: Multi-drug-resistant tuberculosis (MDR-TB) has emerged as a challenge to global tuberculosis (TB) control and remains a major public health concern in many countries. Diabetes mellitus (DM) is an increasingly recognized comorbidity that can both accelerate TB disease and complicate its treatment. The aim of this study is to summarize available evidence on the association of DM and MDR-TB among TB patients and to provide a pooled estimate of risks. METHODS: All studies published in English before October 2016 will be searched using comprehensive search strings through PubMed, EMBASE, Web of Science, and WHO Global Health Library databases which have reported the association of DM and MDR-TB in adults with TB (age > =15)...
January 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28062213/anti-fibrotic-effects-of-bone-morphogenetic-protein-7-modified-bone-marrow-mesenchymal-stem-cells-on-silica-induced-pulmonary-fibrosis
#18
Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu, Ximeng Lian, Piye Niu, Caixia Guo, Lin Tian
Silicosis is an occupational lung disease caused by exposure to small particles of crystalline silica, which ultimately results in diffuse pulmonary fibrosis. Evidence indicates an anti-fibrotic role of bone morphogenetic protein-7 (BMP-7) and bone marrow mesenchymal stem cells (BMSCs) in lung diseases. Therefore, strategies incorporating genetic engineering and stem cell biology might have a tremendous potential to treat critical injuries and diseases. Therefore, we modified BMSCs to overexpress the BMP-7 gene (BMP-7-BMSCs) by lentivirus transduction, and then evaluated whether fibrotic processes were inhibited by these cells in vivo...
January 4, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28054008/infodemiological-data-concerning-silicosis-in-the-usa-in-the-period-2004-2010-correlating-with-real-world-statistical-data
#19
Nicola Luigi Bragazzi, Guglielmo Dini, Alessandra Toletone, Francesco Brigo, Paolo Durando
This article reports data concerning silicosis-related web-activities using Google Trends (GT) capturing the Internet behavior in the USA for the period 2004-2010. GT-generated data were then compared with the most recent available epidemiological data of silicosis mortality obtained from the Centers for Disease Control and Prevention for the same study period. Statistically significant correlations with epidemiological data of silicosis (r=0.805, p-value <0.05) and other related web searches were found...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28051197/silicotuberculosis-with-esophagobronchial-fistula-and-broncholithiasis
#20
Hua Zhang, Li Li, Xiao-Wei Sun, Chun-Ling Zhang
A 69-year-old woman was admitted to hospital 4 times from November 2007 to June 2009. The patient had silicosis complicated by broncholithiasis, esophagobronchial fistula, and relapsed tuberculosis. She had worked as a stone crusher for 3 years and was exposed to a large amount of quartz dust. Barium esophagography, gastroesophageal endoscopy, and biopsy suggested esophageal-related chronic inflammation and ulcer, which probably caused the repeated esophagobronchial fistulas observed. Bronchoscopy revealed a free broncholithiasis in the left main bronchus...
January 2017: International Journal of Occupational and Environmental Medicine
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