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https://www.readbyqxmd.com/read/28088237/association-between-diabetes-mellitus-and-multi-drug-resistant-tuberculosis-a-protocol-for-a-systematic-review-and-meta-analysis
#1
Balewgizie Sileshi Tegegne, Tesfa Dejenie Habtewold, Melkamu Merid Mengesha, Johannes G M Burgerhof
INTRODUCTION: Multi-drug-resistant tuberculosis (MDR-TB) has emerged as a challenge to global tuberculosis (TB) control and remains a major public health concern in many countries. Diabetes mellitus (DM) is an increasingly recognized comorbidity that can both accelerate TB disease and complicate its treatment. The aim of this study is to summarize available evidence on the association of DM and MDR-TB among TB patients and to provide a pooled estimate of risks. METHODS: All studies published in English before October 2016 will be searched using comprehensive search strings through PubMed, EMBASE, Web of Science, and WHO Global Health Library databases which have reported the association of DM and MDR-TB in adults with TB (age > =15)...
January 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28062213/anti-fibrotic-effects-of-bone-morphogenetic-protein-7-modified-bone-marrow-mesenchymal-stem-cells-on-silica-induced-pulmonary-fibrosis
#2
Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu, Ximeng Lian, Piye Niu, Caixia Guo, Lin Tian
Silicosis is an occupational lung disease caused by exposure to small particles of crystalline silica, which ultimately results in diffuse pulmonary fibrosis. Evidence indicates an anti-fibrotic role of bone morphogenetic protein-7 (BMP-7) and bone marrow mesenchymal stem cells (BMSCs) in lung diseases. Therefore, strategies incorporating genetic engineering and stem cell biology might have a tremendous potential to treat critical injuries and diseases. Therefore, we modified BMSCs to overexpress the BMP-7 gene (BMP-7-BMSCs) by lentivirus transduction, and then evaluated whether fibrotic processes were inhibited by these cells in vivo...
January 4, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28054008/infodemiological-data-concerning-silicosis-in-the-usa-in-the-period-2004-2010-correlating-with-real-world-statistical-data
#3
Nicola Luigi Bragazzi, Guglielmo Dini, Alessandra Toletone, Francesco Brigo, Paolo Durando
This article reports data concerning silicosis-related web-activities using Google Trends (GT) capturing the Internet behavior in the USA for the period 2004-2010. GT-generated data were then compared with the most recent available epidemiological data of silicosis mortality obtained from the Centers for Disease Control and Prevention for the same study period. Statistically significant correlations with epidemiological data of silicosis (r=0.805, p-value <0.05) and other related web searches were found...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28051197/silicotuberculosis-with-esophagobronchial-fistula-and-broncholithiasis
#4
Hua Zhang, Li Li, Xiao-Wei Sun, Chun-Ling Zhang
A 69-year-old woman was admitted to hospital 4 times from November 2007 to June 2009. The patient had silicosis complicated by broncholithiasis, esophagobronchial fistula, and relapsed tuberculosis. She had worked as a stone crusher for 3 years and was exposed to a large amount of quartz dust. Barium esophagography, gastroesophageal endoscopy, and biopsy suggested esophageal-related chronic inflammation and ulcer, which probably caused the repeated esophagobronchial fistulas observed. Bronchoscopy revealed a free broncholithiasis in the left main bronchus...
January 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28043619/identifying-patients-at-high-risk-of-tuberculosis-recurrence
#5
Ruxana T Sadikot
Several studies have been done in relation to recurrence of tuberculosis (TB) following completion of treatment. However, recurrence of TB is still a major problem from a public health perspective in high-burden countries, where no special attention is being given to this issue. Disease recurrence is an important indicator of the efficacy of antituberculosis treatment. The rate of recurrence is highly variable and has been estimated to range from 4.9% to 25%. This variability is not only a reflection of regional epidemiology of recurrence but differences in the definitions used by the TB control programs...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28018477/differential-activation-of-raw-264-7-macrophages-by-size-segregated-crystalline-silica
#6
Steven E Mischler, Emanuele G Cauda, Michelangelo Di Giuseppe, Linda J McWilliams, Claudette St Croix, Ming Sun, Jonathan Franks, Luis A Ortiz
BACKGROUND: Occupational exposure to crystalline silica is a well-established occupational hazard. Once in the lung, crystalline silica particles can result in the activation of alveolar macrophages (AM), potentially leading to silicosis, a fibrotic lung disease. Because the activation of alveolar macrophages is the beginning step in a complicated inflammatory cascade, it is necessary to define the particle characteristics resulting in this activation. The aim of this research was to determine the effect of the size of crystalline silica particles on the activation of macrophages...
2016: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/27995130/biometric-monitoring-in-silicosis-to-detect-early-disease-and-monitor-lung-injury-not-quite-there
#7
Daniel Weiler Ravell, Hashem Bishara
Biometric monitoring in exposure to silica dust http://ow.ly/qRrB303lMDg.
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27995129/biometric-monitoring-in-silicosis-to-detect-early-disease-and-monitor-lung-injury-not-quite-there
#8
Noa Ophir, Elizabeth Fireman
Biomonitoring of artificial stone-exposed workers http://ow.ly/Ut4J304amUr.
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27992190/unveiling-the-variability-of-quartz-hazard-in-light-of-recent-toxicological-findings
#9
Cristina Pavan, Bice Fubini
The variability of quartz hazard stands as one of the most puzzling issues in particle toxicology, notwithstanding the fact that silicosis, the most ancient occupational disease, was the very topic from which the study of the toxicity of particulates developed. Over the years, other adverse effects of silica particles (i.e., lung cancer and autoimmune diseases) were detected and described. However, a few gaps are still present in the physicochemical determinants and cellular pathways involved in the mechanisms of silica pathogenicity...
December 19, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27976666/fatal-silicosis-in-a-funeral-arts-craftsman
#10
Roberto Calisti, Gianfranco Ballatori
BACKGROUND: The current scientific debate on silica and cancer has often led to overlooking the persisting risk of lung fibrosis from crystalline silica. CASE REPORT: During 2000, when 54 years old, a funeral arts' craftsman began to suffer from persistent, hacking cough; radiography and high resolution computed tomography (HRCT) showed thin sub-pleural nodulations of the lungs, mainly in the upper fields. Two years later, increasing dyspnoea appeared and HRCT revealed vast consolidative opacities in both upper fields...
December 13, 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/27965042/do-sanitary-ceramic-workers-have-a-worse-presentation-of-chest-radiographs-or-pulmonary-function-tests-than-other-ceramic-workers
#11
Yu-Chung Tsao, Su-Hsun Liu, I-Shiang Tzeng, Tsung-Han Hsieh, Jau-Yuan Chen, Jiin-Chyuan John Luo
BACKGROUND/PURPOSE: Silicosis remains the most prevalent occupational disease worldwide. There have been no specific studies focusing on the association between exposure settings at work and the clinical severity in silicosis patients. In this study, we describe and compare the clinical characteristics and silicosis-associated exposure history at work among workers from several types of ceramic production facilities in Taiwan. METHODS: We reviewed the medical records of 221 patients who were first diagnosed with silicosis at the Occupational Medicine Clinic of Northern Taiwan in 2012...
December 10, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27931056/-guideline-s2k-awmf-of-the-deutsche-gesellschaft-f%C3%A3-r-pneumologie-und-beatmungsmedizin-and-the-deutsche-gesellschaft-f%C3%A3-r-arbeitsmedizin-und-umweltmedizin-diagnostics-and-expert-opinion-in-the-occupational-disease-no-4101-silicosis-including-coal-worker-s-pneumoconiosis
#12
X Baur, M Heger, R M Bohle, K G Hering, K Hofmann-Preiß, D Nowak, A Tannapfel, H Teschler, T Voshaar, T Kraus
During the last 1.5 years an update of the guideline on silicosis was made by an interdisciplinary working group. New medical and scientific knowledge and the experience in expert opinion practice were taken into account.By preparing the initial guideline in 2010 standardization of diagnostics and adaption of the "Moers convention" which was not based on medical knowledge was in the focus, whereas the current update deals with fine emendation and extension, especially of the compensation rate (adaption with the Reichenhall recommendation)...
December 2016: Pneumologie
https://www.readbyqxmd.com/read/27916032/-lung-transplantation-for-phase-%C3%A2-silicosis-a-series-of-32-cases
#13
W J Mao, J Y Chen, M F Zheng, R Chen, Y J He, F Liu, S G Ye, R G Lu
Objective: To evaluate the effect of lung transplantation for phase Ⅲ silicosis. Methods: From September 2002 to September 2015, 32 patients with end-stage silicosis underwent lung transplantation at Department of Thoracic Surgery, Affiliated Wuxi People's Hospital, Nanjing Medical University. There were 29 male and 3 female patients aged from 24 to 63 years. Thirty-two patients were diagnosed as phase Ⅲ silicosis by the local occupational disease prevention and control center. Fifteen patients were type Ⅰ respiratory failure and 17 patients were type Ⅱ...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27916030/-short-term-outcomes-of-lung-transplant-recipients-using-organs-from-brain-death-donors
#14
W X He, C Jiang, X G Liu, W Huang, C Chen, L Jiang, B Yang, K Wu, Q K Chen, Y Yang, Y M Yu, G N Jiang
Objective: To assess short-term outcomes after lung transplantation with organs procured following brain death. Methods: Between April 2015 and July 2016, all 17 recipients after lung transplantation using organs from brain death donors (DBD) at Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine were enrolled in this study. All patients were male, aging (60±7) years, including 11 chronic obstructive pulmonary disease, 5 idiopathic pulmonary fibrosis, 1 silicosis...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27894297/pulmonary-hypertension-and-vascular-remodeling-in-mice-exposed-to-crystalline-silica
#15
Igor N Zelko, Jianxin Zhu, Jeffrey D Ritzenthaler, Jesse Roman
BACKGROUND: Occupational and environmental exposure to crystalline silica may lead to the development of silicosis, which is characterized by inflammation and progressive fibrosis. A substantial number of patients diagnosed with silicosis develop pulmonary hypertension. Pulmonary hypertension associated with silicosis and with related restrictive lung diseases significantly reduces survival in affected subjects. An animal model of silicosis has been described previously however, the magnitude of vascular remodeling and hemodynamic effects of inhaled silica are largely unknown...
November 28, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27866552/-silicosis-with-tracheobronchopathia-osteochondroplastica-one-case-report
#16
N Wu, Q Ye, L L Xu
No abstract text is available yet for this article.
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866541/-influencing-factors-for-postoperative-survival-of-patients-with-stage-iii-silicosis-treated-by-lung-transplantation
#17
W J Mao, X W Nie, W Xia, M F Zheng, R Chen, Y J He, F Liu, S G Ye, R G Lu, J Y Chen
Objective: To investigate the clinical effect, postoperative complications, and causes of death in the treatment of stage III silicosis with lung transplantation and the influencing factors for survival. Methods: A retrospective analysis was performed for the clinical data of 32 patients with stage III silicosis who underwent lung transplantation in our hospital from September 2002 to September 2015. The survival, causes of death, and postoperative complications were analyzed. The Kaplan-Meier method was used to plot survival curves, the log-rank test was used to compare the influence of each factor on survival rates, and the multivariate Cox proportional hazards regression model was used to evaluate the influence of each factor on survival...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866190/role-of-mcpip1-in-the-endothelial-mesenchymal-transition-induced-by-silica
#18
Jie Chao, Xingang Wang, Yuxia Zhang, Tiebing Zhu, Wei Zhang, Zewei Zhou, Jian Yang, Bing Han, Yusi Cheng, Xiaojie Tu, Honghong Yao
BACKGROUND: Silicosis is characterized by the accumulation of fibroblasts and the excessive deposition of extracellular matrix. Fibroblast generation via endothelial-mesenchymal transition (EndMT) is one process responsible for this accumulation of fibroblasts. However, the mechanisms underlying EndMT remain unknown. METHODS: Human umbilical vein endothelial cells (HUVECs) were exposed to SiO2 (50 µg/cm2). Specific endothelial and mesenchymal markers were evaluated using immunofluorescence and western blot analysis...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27865796/bletilla-striata-medicinal-uses-phytochemistry-and-pharmacological-activities
#19
REVIEW
Xirui He, Xiaoxiao Wang, Jiacheng Fang, Zefeng Zhao, Linhong Huang, Hao Guo, Xiaohui Zheng
ETHNOPHARMACOLOGICAL RELEVANCE: Bletilla striata (Thunb.) Reichb. f. (Orchidaceae), also known as Hyacinth Orchid and Baiji (Simplified Chinese: ), not only has been widely used for the treatment of hematemesis, hemoptysis, and traumatic bleeding due to the efficacy of arresting bleeding with astringent action, but also has been applied topically to overcome ulcers, sores, swellings, and chapped skin due to the efficacy of dispersing swelling and promoting tissue regeneration. Additional medical applications include the treatment of tuberculosis, malignant ulcers, hemorrhoids, anthrax, eye diseases, and silicosis...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27843169/silicosis-and-silicotuberculosis-in-india
#20
Nandini Sharma, Debashish Kundu, Sunita Dhaked, Anand Das
No abstract text is available yet for this article.
October 1, 2016: Bulletin of the World Health Organization
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