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https://www.readbyqxmd.com/read/28927166/experimental-evaluation-of-respirable-dust-and-crystalline-silica-controls-during-simulated-performance-of-stone-countertop-fabrication-tasks-with-powered-hand-tools
#1
David L Johnson, Margaret L Phillips, Chaolong Qi, Anthony T Van, Danielle A Hawley
Objectives: Workers who fabricate stone countertops using hand tools are at risk of silicosis from overexposure to respirable crystalline silica. This study explored the efficacy of simple engineering controls that can be used for dust suppression during use of hand tools by stone countertop fabricators. Methods: Controlled experiments were conducted to measure whether wet methods and on-tool local exhaust ventilation (LEV) reduced respirable dust (RD) exposures during use of various powered hand tools on quartz-rich engineered stone...
July 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28916165/muc1-deficiency-exacerbates-pulmonary-fibrosis-in-a-mouse-model-of-silicosis
#2
Kosuke Kato, Marina A Zemskova, Alec D Hanss, Marianne M Kim, Sandra J Gendler, Ross Summer, Kwang Chul Kim
BACKGROUND: MUC1 (MUC in human and Muc in animals) is a membrane-tethered mucin expressed on the apical surface of lung epithelial cells. However, in the lungs of patients with interstitial lung disease, MUC1 is aberrantly expressed in hyperplastic alveolar type II epithelial (ATII) cells and alveolar macrophages (AM), and elevated levels of extracellular MUC1 are found in bronchoalveolar lavage (BAL) fluid and the serum of these patients. While pro-fibrotic effects of extracellular MUC1 have recently been described in cultured fibroblasts, the contribution of MUC1 to the pathobiology of pulmonary fibrosis is unknown...
September 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28914424/new-perspectives-in-nanotherapeutics-for-chronic-respiratory-diseases
#3
Adriana Lopes da Silva, Fernanda Ferreira Cruz, Patricia Rieken Macedo Roccco, Marcelo Marcos Morales
According to the World Health Organization (WHO), hundreds of millions of people of all ages and in all countries suffer from chronic respiratory diseases, with particular negative consequences such as poor health-related quality of life, impaired work productivity, and limitations in the activities of daily living. Chronic obstructive pulmonary disease, asthma, occupational lung diseases (such as silicosis), cystic fibrosis, and pulmonary arterial hypertension are the most common of these diseases, and none of them are curable with current therapies...
September 15, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28900284/mir-503-modulates-epithelial-mesenchymal-transition-in-silica-induced-pulmonary-fibrosis-by-targeting-pi3k-p85-and-is-sponged-by-lncrna-malat1
#4
Weiwen Yan, Qiuyun Wu, Wenxi Yao, Yan Li, Yi Liu, Jiali Yuan, Ruhui Han, Jingjin Yang, Xiaoming Ji, Chunhui Ni
Silicosis is a kind of chronic, progressive and incurable lung fibrotic diseases with largely unknown and complex pathogenesis and molecular mechanisms. Mounting evidence suggests that microRNAs (miRNAs, miRs) are involved in the pathogenesis of silicosis. Our previous study based on miRNA microarray had shown that the expression levels of miR-503 were down-regulated in mouse lung tissues of silica-induced pulmonary fibrosis. Here, we validated the decreased expression of miR-503 in the fibrotic mouse lung tissues, human bronchial epithelial cells (HBE) and human lung adenocarcinoma A549 cells which were exposed to silica...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893276/imipramine-blocks-acute-silicosis-in-a-mouse-model
#5
Rupa Biswas, Kevin L Trout, Forrest Jessop, Jack R Harkema, Andrij Holian
BACKGROUND: Inhalation of crystalline silica is associated with pulmonary inflammation and silicosis. Although silicosis remains a prevalent health problem throughout the world, effective treatment choices are limited. Imipramine (IMP) is a FDA approved tricyclic antidepressant drug with lysosomotropic characteristics. The aim of this study was to evaluate the potential for IMP to reduce silicosis and block phagolysosome membrane permeabilization. METHODS: C57BL/6 alveolar macrophages (AM) exposed to crystalline silica ± IMP in vitro were assessed for IL-1β release, cytotoxicity, particle uptake, lysosomal stability, and acid sphingomyelinase activity...
September 11, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28893249/assessment-of-the-potential-respiratory-hazard-of-volcanic-ash-from-future-icelandic-eruptions-a-study-of-archived-basaltic-to-rhyolitic-ash-samples
#6
David E Damby, Claire J Horwell, Gudrun Larsen, Thorvaldur Thordarson, Maura Tomatis, Bice Fubini, Ken Donaldson
BACKGROUND: The eruptions of Eyjafjallajökull (2010) and Grímsvötn (2011), Iceland, triggered immediate, international consideration of the respiratory health hazard of inhaling volcanic ash, and prompted the need to estimate the potential hazard posed by future eruptions of Iceland's volcanoes to Icelandic and Northern European populations. METHODS: A physicochemical characterization and toxicological assessment was conducted on a suite of archived ash samples spanning the spectrum of past eruptions (basaltic to rhyolitic magmatic composition) of Icelandic volcanoes following a protocol specifically designed by the International Volcanic Health Hazard Network...
September 11, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28882991/artificial-stone-associated-silicosis-a-rapidly-emerging-occupational-lung-disease
#7
Ryan F Hoy, Timothy Baird, Gary Hammerschlag, David Hart, Anthony R Johnson, Paul King, Michael Putt, Deborah H Yates
INTRODUCTION: Artificial stone is an increasingly popular material used to fabricate kitchen and bathroom benchtops. Cutting and grinding artificial stone is associated with generation of very high levels of respirable crystalline silica, and the frequency of cases of severe silicosis associated with this exposure is rapidly increasing. AIM: To report the characteristics of a clinical series of Australian workers with artificial stone-associated silicosis. METHODS: Respiratory physicians voluntarily reported cases of artificial stone-associated silicosis identified in their clinical practices...
September 7, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28871617/what-is-expected-in-lung-function-after-lung-transplantation-due-to-end-stage-pulmonary-silicosis
#8
Luzielio Alves Sidney-Filho, Guilherme Watte, Pedro Augusto Reck Dos Santos, Sadi Marcelo Schio, Spencer Marcantonio Camargo, Fabíola Adélia Perin, Bruno Hochhegger, Jose Carlos Felicetti, Jose de Jesus Peixoto Camargo, Jose da Silva Moreira
In this study, we aimed to determine the impact of lung transplantation (LTx) on pulmonary function tests (PFTs) and survival among patients with end-stage silicosis. We included patients with end-stage silicosis on the wait list for LTx, between January 1989 and July 2015 (N = 26). Sixteen of these patients received LTx; 10 were eligible, but did not undergo LTx (non-LTx) during the study period. Retrospective information on PFTs (spirometry [volumes and flows], 6-minute walking test [6MWT], and DLCO) was retrieved from patients' medical charts, including baseline information for all patients and follow-up information for the LTx...
September 4, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28855120/sio2-induced-release-of-svegfrs-from-pulmonary-macrophages
#9
Jie Chao, Yan Lv, Jin Chen, Jing Wang, Honghong Yao
BACKGROUND: The inhalation of silicon dioxide (SiO2) particles causes silicosis, a stubborn pulmonary disease that is characterized by alveolar inflammation during the early stage. Soluble cytokine receptors (SCRs) play important roles in regulating inflammation by either attenuating or promoting cytokine signaling. However, the role of SCRs in silicosis remains unknown. METHODS AND RESULTS: Luminex assays revealed increased soluble vascular endothelial growth factor receptor (sVEGFR) family levels in the plasma of silicosis patients...
August 30, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28853529/-artificial-stone-silicosis-the-israel-epidemic-current-view
#10
REVIEW
Osnat Shtraichman, Mordechai R Kramer
Silicosis is a fibrotic occupational pulmonary disease that results from over-exposure to crystalline silica-containing dust. Silicosis is a progressive disease which can often lead to advanced respiratory failure, the need for lung transplantation or death. There are a number of silicosis associated diseases which constitute diagnostic challenges, as well as contribute to further morbidity. Although preventable through appropriate workplace precautions, silicosis not only remains an endemic disease worldwide, it has also manifested a resurgence of epidemic disease in recent years, as seen in the inclining prevalence of disease in Israel...
August 2017: Harefuah
https://www.readbyqxmd.com/read/28831210/il-10-producing-b-cells-suppress-effector-t-cells-activation-and-promote-regulatory-t-cells-in-crystalline-silica-induced-inflammatory-response-in-vitro
#11
Yiping Lu, Fangwei Liu, Chao Li, Ying Chen, Dong Weng, Jie Chen
Long-term exposure to crystalline silica leads to silicosis, which is characterized by persistent lung inflammation and lung fibrosis. Multiple immune cells have been demonstrated to participate in crystalline silica-induced immune responses. Our previous study indicated that B10 could control lung inflammation through modulating the Th balance in experimental silicosis in mice. However, the regulatory mechanism of B10 on CD4(+) T cells is still unclear. MACS-sorted CD19(+) B cells from the three different groups were cultured with CD4(+) T cells either with or without transwell insert plates to evaluate the effects of B10 on CD4(+) T cells, including Teff and Treg...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28805487/state-of-the-art-nanopathological-diagnostics
#12
Luca Roncati, Giuseppe Barbolini
The nanopathological diagnostics (ND) is an ultra-specialized branch of pathological anatomy aimed to identify the nanoparticles of metallic, semimetallic, or nonmetallic elements in the inorganic particulate matter present inside pathological tissues, even on the nanometer scale. ND exploits an environmental scanning electron microscope, connected to an X-ray microprobe mounted on an energy-dispersive spectrometer. The searching of nanoparticles can be performed on paraffin-embedded material, omitting emissions of black overlay and plating procedures...
September 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28802207/the-effect-of-aluminium-and-sodium-impurities-on-the-in-vitro-toxicity-and-pro-inflammatory-potential-of-cristobalite
#13
C Nattrass, C J Horwell, D E Damby, D Brown, V Stone
BACKGROUND: Exposure to crystalline silica (SiO2), in the form of quartz, tridymite or cristobalite, can cause respiratory diseases, such as silicosis. However, the observed toxicity and pathogenicity of crystalline silica is highly variable. This has been attributed to a number of inherent and external factors, including the presence of impurities. In cristobalite-rich dusts, substitutions of aluminium (Al) for silicon (Si) in the cristobalite structure, and impurities occluding the silica surface, have been hypothesised to decrease its toxicity...
August 9, 2017: Environmental Research
https://www.readbyqxmd.com/read/28794637/the-role-of-mediastinoscopy-in-the-diagnosis-of-non-lung-cancer-diseases
#14
Serdar Onat, Gungor Ates, Alper Avcı, Tekin Yıldız, Ali Birak, Cihan Akgul Ozmen, Refik Ulku
BACKGROUND: Mediastinoscopy is a good method to evaluate mediastinal lesions. We sought to determine the current role of mediastinoscopy in the investigation of non-lung cancer patients with mediastinal lymphadenopathy. MATERIALS AND METHODS: We retrospectively reviewed clinical parameters (age, gender, histological diagnosis, morbidity, mortality) of all patients without lung cancer who consecutively underwent mediastinoscopy in Hospital of Faculty of Medicine of Dicle University between June 2003 and December 2016...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28780804/-the-clinical-ananysis-of-10-cases-of-accelerated-silicosis
#15
Y Li, G M Luo, X H Zhang
No abstract text is available yet for this article.
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28774280/public-health-implications-of-changing-patterns-of-recruitment-into-the-south-african-mining-industry-1973-2012-a-database-analysis
#16
Rodney Ehrlich, Alex Montgomery, Paula Akugizibwe, Gregg Gonsalves
BACKGROUND: The triple epidemic of silicosis, tuberculosis and HIV infection among migrant miners from South Africa and neighbouring countries who have worked in the South African mining industry is currently the target of regional and international control efforts. These initiatives are hampered by a lack of information on this population. METHODS: This study analysed the major South African mining recruitment database for the period 1973 to 2012 by calendar intervals and demographic and occupational characteristics...
August 3, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28727677/surveillance-for-silicosis-deaths-among-persons-aged-15-44-years-united-states-1999-2015
#17
Jacek M Mazurek, John M Wood, Patricia L Schleiff, David N Weissman
Silicosis is usually a disease of long latency affecting mostly older workers; therefore, silicosis deaths in young adults (aged 15-44 years) suggests acute or accelerated disease.* To understand the circumstances surrounding silicosis deaths among young persons, CDC analyzed the underlying and contributing causes(†) of death using multiple cause-of-death data (1999-2015) and industry and occupation information abstracted from death certificates (1999-2013). During 1999-2015, among 55 pneumoconiosis deaths of young adults with International Classification of Diseases, Tenth Revision (ICD-10) code J62 (pneumoconiosis due to dust containing silica),(§) 38 (69%) had code J62...
July 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28660869/a-reliability-and-readability-analysis-of-silicosis-related-italian-websites-implications-for-occupational-health
#18
Guglielmo Dini, Nicola Luigi Bragazzi, Beatrice D'Amico, Alfredo Montecucco, Stanley C Igwe, Francesco Brigo, Alessandra Toletone, Paolo Durando
BACKGROUND: Silicosis represents a "classical" occupational disease characterized by a renewed interest. New risk factors are emerging, such as sandblasting in the jeans industry or hydrofracking, leading to clusters of acute or massive cases. OBJECTIVES: Given that the Internet could represent a worker education and empowerment tool, and considering the increase in popularity of silicosis-related information, we aimed at systematically analyzing the reliability and readability of online silicosis-relevant information...
June 28, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28622458/bullous-pemphigoid-associated-with-silicosis
#19
T Zhu, D L Ma, Y P Zeng, L Song, L Li
An 87-year-old man presented with multiple erythemas accompanied by itching on bilateral axillae, groins and buttocks for 3 months, which aggravated with blisters and bullae for 1 month. The physical examination revealed multiple tense blisters and bullae with erosions and light yellow effusion (Fig. 1a). The histopathological examination of the tissue biopsy showed a subepidermal blister with little inflammatory infiltrate (Fig. 1b). This article is protected by copyright. All rights reserved.
June 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28617149/comparison-of-airway-deposition-distributions-of-particles-in-healthy-and-diseased-workers-in-an-egyptian-industrial-site
#20
Péter Füri, Werner Hofmann, Ágnes Jókay, Imre Balásházy, Mona Moustafa, Blanka Czitrovszky, Gábor Kudela, Árpád Farkas
The objective of this study is the prediction and comparison of airway deposition patterns of an industrial aerosol in healthy workers and workers suffering from silicosis. Mass concentrations and related size distributions of particulate matter were measured in the industrial area of Samalut in Minia, Egypt. A novel stochastic lung deposition model, simulating the symptoms of silicosis by chronic bronchial (Br) obstruction and emphysema in the acinar (Ac) region, was applied to compute mass deposition fractions, deposition density, deposition rate and deposition density rate distributions in healthy and diseased workers...
June 15, 2017: Inhalation Toxicology
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