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Rania R Abdelaziz, Wagdi F Elkashef, Eman Said
Silicosis is a crippling respiratory disorder characterized by massive lung inflammation and fibrosis. The current study provides evidence on the protective potential of tadalafil; a specific phosphodiesterase-5 (PDE-5) inhibitor against experimentally-induced pulmonary silicosis in rats. Silicosis was induced by intranasal instillation of crystalline silica (50mg/rat). Halofuginone hydrobromide; a standard collagen-1 synthesis inhibitor was selected as a reference anti-fibrotic. Daily oral administration of tadalafil (1mg/kg) for 8weeks significantly ameliorated silica-induced pulmonary damage...
October 18, 2016: International Immunopharmacology
James J Anderson, Kwun M Fong, David B Godbolt, Steven C Leong, Henry M Marshall
No abstract text is available yet for this article.
October 2016: Journal of Bronchology & Interventional Pulmonology
Tian Yang, Jinyuan Wang, Yamei Pang, Xiaomin Dang, Hui Ren, Ya Liu, Mingwei Chen, Dong Shang
Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains to be fully elucidated Emodin shows antifibrotic effects in several organs with fibrosis, however, it has not been investigated in pulmonary silicosis. In the present study, the possible mechanism of lung fibrosis and the antifibrotic effect of emodin in silica inhalation‑induced lung fibrosis were investigated. Pulmonary silica particle inhalation was used to induce lung fibrosis in mice...
October 12, 2016: Molecular Medicine Reports
Patricia L Schleiff, Jacek M Mazurek, Mary Jo Reilly, Kenneth D Rosenman, Martha B Yoder, Margaret E Lumia, Karen Worthington
CDC's National Institute for Occupational Safety and Health (NIOSH), state health departments, and other state entities maintain a state-based surveillance program of confirmed silicosis cases. Data on confirmed cases are collected and compiled by state entities and submitted to CDC. This report summarizes information for cases of silicosis that were reported to CDC for 2003-2011 by Michigan and New Jersey, the only states that continue to provide data voluntarily to NIOSH. The data for this report were final as of January 8, 2015...
October 14, 2016: MMWR. Morbidity and Mortality Weekly Report
Noa Ophir, Amir Bar Shai, Yifat Alkalay, Shani Israeli, Rafi Korenstein, Mordechai R Kramer, Elizabeth Fireman
The manufacture of kitchen and bath countertops in Israel is based mainly on artificial stone that contains 93% silica as natural quartz, and ∼3500 workers are involved in cutting and processing it. Artificial stone produces high concentrations of silica dust. Exposure to crystalline silica may cause silicosis, an irreversible lung disease. Our aim was to screen exposed workers by quantitative biometric monitoring of functional and inflammatory parameters. 68 exposed artificial stone workers were compared to 48 nonexposed individuals (controls)...
January 2016: ERJ Open Research
Jay Champlin, Rachael Edwards, Sudhakar Pipavath
Occupational lung diseases span a variety of pulmonary disorders caused by inhalation of dusts or chemical antigens in a vocational setting. Included in these are the classic mineral pneumoconioses of silicosis, coal worker's pneumoconiosis, and asbestos-related diseases as well as many immune-mediated and airway-centric diseases, and new and emerging disorders. Although some of these have characteristic imaging appearances, a multidisciplinary approach with focus on occupational exposure history is essential to proper diagnosis...
November 2016: Radiologic Clinics of North America
Chao Li, Sitong Du, Yiping Lu, Xiaowei Lu, Fangwei Liu, Ying Chen, Dong Weng, Jie Chen
Long term pulmonary exposure to crystalline silica leads to silicosis that manifests progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite efforts to eliminate silicosis, clinical cases continue to occur in both developing and developed countries. The exact mechanisms of crystalline silica-induced pulmonary fibrosis remain elusive. Herein, we find that 4-1BB is induced in response to crystalline silica injury in lungs and that it is highly expressed during development of experimental silicosis...
2016: Theranostics
Ahuva Grubstein, Osnat Shtraichman, Elizabeth Fireman, Gil N Bachar, Noa Noach-Ophir, Mordechai R Kramer
OBJECTIVE: The aim of this study was to describe the computed tomography (CT) findings and correlate pulmonary function tests (PFTs) of silicosis patients with emphasis on the findings in lung transplantation (LTX) recipients. METHODS: We studied the chest CT scans from 82 marble workers exposed to artificial stone dust and who had a diagnosis of silicosis, of whom 13 patients underwent LTX. Silicosis-associated findings were graded and correlated to concomitant PFT...
September 27, 2016: Journal of Computer Assisted Tomography
Nan Liu, Ling Xue, Yi Guan, Qing Zhao Li, Fu Yuan Cao, Shu Lan Pang, Wei Jun Guan
Silicosis is one of the most serious occupational diseases in China and dates back to centuries ago. In this study, we successfully established a rat model of silicosis by intratracheal silica injection for 28 days and determined hydroxyproline levels to evaluate collagen metabolism in lung homogenates. Oxidative stress status was evaluated by detecting catalase and glutathione peroxidase activities. Expression levels of peroxiredoxins (Prx I and Prx VI) were detected by Western blotting. Pulmonary surfactant protein A (SP-A) levels in rat serum and lung tissue were analyzed by ELISA, and SP-A and Prx expression levels in lung tissues were detected by immunohistochemistry...
August 2016: Biomedical and Environmental Sciences: BES
Mutlay Sayan, Brooke T Mossman
The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately a decade ago. Priming and activation of these intracellular protein platforms trigger the maturation of pro-inflammatory chemokines and cytokines, most notably, interleukin-1β (IL-1β) and IL-18, to promulgate innate immune defenses. Although classically studied in models of gout, Type II diabetes, Alzheimer's disease, and multiple sclerosis, the importance and mechanisms of action of inflammasome priming and activation have recently been elucidated in cells of the respiratory tract where they modulate the responses to a number of inhaled pathogenic particles and fibres...
2016: Particle and Fibre Toxicology
Arthur L Miller, Andrew Todd Weakley, Peter R Griffiths, Emanuele G Cauda, Sean Bayman
In order to help reduce silicosis in miners, the National Institute for Occupational Health and Safety (NIOSH) is developing field-portable methods for measuring airborne respirable crystalline silica (RCS), specifically the polymorph α-quartz, in mine dusts. In this study we demonstrate the feasibility of end-of-shift measurement of α-quartz using a direct-on-filter (DoF) method to analyze coal mine dust samples deposited onto polyvinyl chloride filters. The DoF method is potentially amenable for on-site analyses, but deviates from the current regulatory determination of RCS for coal mines by eliminating two sample preparation steps: ashing the sampling filter and redepositing the ash prior to quantification by Fourier transform infrared (FT-IR) spectrometry...
September 19, 2016: Applied Spectroscopy
S Piel, M Kreuter, F Herth, H-U Kauczor, C-P Heußel
CLINICAL/METHODICAL ISSUE: Granulomas as signs of specific inflammation of the lungs are found in various diseases with pulmonary manifestations and represent an important imaging finding. STANDARD RADIOLOGICAL METHODS: The standard imaging modality for the work-up of granulomatous diseases of the lungs is most often thin-slice computed tomography (CT). There are a few instances, e. g. tuberculosis, sarcoidosis and silicosis, where a chest radiograph still plays an important role...
October 2016: Der Radiologe
Mohammad Normohammadi, Hossein Kakooei, Leila Omidi, Saeed Yari, Rasul Alimi
BACKGROUND: Building demolition can lead to emission of dust into the environment. Exposure to silica dust may be considered as an important hazard in these sites. The objectives of this research were to determine the amount of workers' exposure to crystalline silica dust and assess the relative risk of silicosis and the excess lifetime risk of mortality from lung cancer in demolition workers. METHODS: Four sites in the Tehran megacity region were selected. Silica dust was collected using the National Institute for Occupational Safety and Health method 7601 and determined spectrophotometrically...
September 2016: Safety and Health At Work
Xianan Zhang, Xiaowei Jia, Liangying Mei, Min Zheng, Chen Yu, Meng Ye
BACKGROUND: Silicosis is a respiratory disease caused by long-term silica dust exposure. Our previous study has demonstrated that silica mediates the activation of phosphatidylinositol 3-kinase (PI3K)/phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/serine or threonine kinase (AKT)/mitogen-activated protein kinases (MAPK)/AP-1 pathway in human embryo lung fibroblasts (HELFs). The purpose of this study is to identify genome-wide aberrant DNA methylation profiling in lung tissues from silicosis patients...
August 2016: Journal of Thoracic Disease
Wei Zhang, Mei Zhang, Zhongjiang Wang, Yusi Cheng, Haijun Liu, Zewei Zhou, Bing Han, Baoan Chen, Honghong Yao, Jie Chao
BACKGROUND: Silicosis is a systemic disease caused by inhaling silicon dioxide (SiO2); early stages are characterized by alveolar inflammation, and later stages are characterized by progressive lung fibrosis. Mounting evidence indicates that high-mobility group box 1 (HMGB1) is involved in pulmonary fibrosis. Whether neogambogic acid (NGA) inhibits macrophage and fibroblast activation induced by SiO2 by targeting HMGB1 remains unclear. METHODS AND RESULTS: Experiments using cultured mouse macrophages (RAW264...
October 15, 2016: Toxicology and Applied Pharmacology
Han Loong Tan, Mohamed Faisal, Chun Ian Soo, Andrea Y L Ban, Roslina Abdul Manap, Tidi M Hassan
BACKGROUND: Dental laboratory technicians are at risk of developing occupational respiratory diseases due to exposure to various potentially toxic substances in their working environment. Since 1939, few cases of silicosis among dental technician have been reported. CASE PRESENTATION: We illustrate a 38 year-old female, who worked in a dental laboratory for 20 years, initially treated as pulmonary tuberculosis and chronic necrotising aspergillosis without much improvement...
2016: BMC Pulmonary Medicine
Wang Xiaojun, Liu Yan, Xu Hong, Zhang Xianghong, Li Shifeng, Xu Dingjie, Gao Xuemin, Zhang Lijuan, Zhang Bonan, Wei Zhongqiu, Wang Ruimin, Darrell Brann, Yang Fang
Silicosis is the most serious occupational disease in China. The objective of this study was to screen various proteins related to mechanisms of the pathogenesis of silicosis underlying the anti-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) using proteomic profile analysis. We also aimed to explore a potential mechanism of acetylated α-tubulin (α-Ac-Tub) regulation by Ac-SDKP. Two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/TOF MS) were used to assess the different protein expression profiles between control and silicosis rats treated with or without Ac-SDKP...
2016: Scientific Reports
J J Tejado, J Guillén, A Baeza
Workers in the granite industry face an occupational hazard: silicosis due to the crystalline silica present in inhalable dust. As granite can also present a variable, and occasionally significant, content of naturally occurring radionuclides, they may also face a radiological hazard. In order to assess the risk, a granite industry with a quarry and processing factory was selected to assess the occupational exposure. Three main potential pathways were observed: external irradiation, inhalation of granite dust, and radon exposure...
August 12, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Jung-Il Kim
Author reports a case of 67- years- old men referred to Donga University Hospital silicosis who had worked in tunnel drilling where presumably had been exposed to high concentration free silica for almost 20 yr. This report is considered the first in Korea to the best of our knowledge since no cases on silicosis could be reported in this occupation in reviewing various literature sources in Korea. The physician's first impression was lung cancer since the CT findings. However, it turned out to be pneumonia and silicosis...
July 2016: Iranian Journal of Public Health
Timothy Baird, Michael Putt, Andrew Dettrick
We present the case of a 26-year-old stonemason with accelerated silicosis in the setting of treatment for psoriasis with the tumour necrosis factor alpha (TNF-alpha) inhibitor adalimumab. Accelerated silicosis is an important occupational lung disease with a poor prognosis and limited treatment options [1]. Although the exact pathogenesis remains unknown, it is suggested that secretion of cytokines, including TNF-alpha, plays a central role in disease progression [1,2]. Importantly, however, TNF-alpha inhibitors, in addition to resulting in an increased risk of infection, are also now being seen to cause interstitial lung disease [3,4]...
September 2016: Respirology Case Reports
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