keyword
MENU ▼
Read by QxMD icon Read
search

silicosis

keyword
https://www.readbyqxmd.com/read/28222740/dibutyryl-camp-attenuates-pulmonary-fibrosis-by-blocking-myofibroblast-differentiation-via-pka-creb-cbp-signaling-in-rats-with-silicosis
#1
Yan Liu, Hong Xu, Yucong Geng, Dingjie Xu, Lijuan Zhang, Yi Yang, Zhongqiu Wei, Bonan Zhang, Shifeng Li, Xuemin Gao, Ruimin Wang, Xianghong Zhang, Darrell Brann, Fang Yang
BACKGROUND: Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by silica. METHODS: A HOPE MED 8050 exposure control apparatus was used to create the silicosis model. Rats were randomly divided into 4 groups: 1)controls for 16 w; 2)silicosis for 16 w; 3)db-cAMP pre-treatment; 4) db-cAMP post-treatment...
February 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28217139/characterizing-particle-size-distributions-of-crystalline-silica-in-gold-mine-dust
#2
Lauren G Chubb, Emanuele G Cauda
Dust containing crystalline silica is common in mining environments in the U.S. and around the world. The exposure to respirable crystalline silica remains an important occupational issue and it can lead to the development of silicosis and other respiratory diseases. Little has been done with regard to the characterization of the crystalline silica content of specific particle sizes of mine-generated dust. Such characterization could improve monitoring techniques and control technologies for crystalline silica, decreasing worker exposure to silica and preventing future incidence of silicosis...
January 2017: Aerosol and Air Quality Research
https://www.readbyqxmd.com/read/28209773/mannan-binding-lectin-a-serum-collectin-suppresses-t-cell-proliferation-via-direct-interaction-with-cell-surface-calreticulin-and-inhibition-of-proximal-t-cell-receptor-signaling
#3
Na Zhao, Jie Wu, Simin Xiong, Liyun Zhang, Xiao Lu, Shangliang Chen, Qifeng Wu, Hailan Wang, Ying Liu, Zhengliang Chen, Daming Zuo
Mannan binding lectin (MBL), initially described to activate the complement pathway, is also known to be involved in the pathogenesis of autoimmune diseases. We report a thus far unknown function of MBL as a suppressor of T-cell activation. MBL markedly inhibited T-cell proliferation induced by anti-CD3 and anti-CD28 antibodies. Moreover, the presence of MBL during T-cell priming interfered with proximal T-cell receptor signaling by decreasing phosphorylation of Lck, ZAP-70, and LAT. MBL bound to T cells through interaction between the collagen-like region of MBL and calreticulin (CRT) expressed on the T-cell surface...
February 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28195659/silica-exposure-and-disease-in-semi-precious-stone-craftsmen-minas-gerais-brazil
#4
Ana Paula S Carneiro, Nayara F T Braz, Eduardo Algranti, Olivia M P A Bezerra, Natália P S Araujo, Lênio S Amaral Eng Hyg, Jean L Edmé, Annie Sobaszek, Nathalie Chérot-Kornobis
BACKGROUND: Brazil is an exporter of precious stones and craftsmen often work in poor conditions. We assessed silica-related diseases among crystal craftsmen and the complexity of its control. METHODS: Case-series including 118 subjects evaluated from 2006 to 2015, based on medical interviews, chest X-rays, spirometry, and respirable silica samples. RESULTS: Median age and length of exposure were 32 and 13 years, respectively. Silicosis, with 1/0 as a threshold, was diagnosed radiologically in 57 individuals (48...
March 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28194086/silicosis-in-the-form-of-progressive-massive-fibrosis-a-diagnostic-challenge
#5
Somnath Bhattacharya, Atin Dey, Amitava Pal, Saurav Kar, Sayantan Saha
Silicosis is a major occupational lung disease with a relatively fatal and irreversible outcome. Early diagnosis for shifting the potential candidates to safe modes of workplace as well as for prevention of further progression is the cornerstone of management. Here, we present a complicated case of silicosis in the form of progressive massive fibrosis, which was initially interpreted as tuberculosis; radiological images had resemblance with tuberculosis and cryptogenic organizing pneumonia. Radiology-guided trucut biopsy was imperative to confirm the diagnosis...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28177948/silicosis-and-autoimmunity
#6
Suni Lee, Hiroaki Hayashi, Hidenori Mastuzaki, Naoko Kumagai-Takei, Takemi Otsuki
PURPOSE OF REVIEW: Of the various environmental, occupational, and medical substances that cause dysregulation of autoimmunity, the effects and causative mechanisms of silica particles and asbestos fibers are discussed in this review. RECENT FINDINGS: With respect to silica, many epidemiological studies have shown a significant association between silica exposure and the occurrence of autoimmune diseases. Although the importance of the NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome as the initial immune reaction against silica particles has been identified, the mechanisms involved that lead to various autoimmune diseases in patients exposed to silica remain largely unknown...
February 7, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28166128/commentary-for-joem-forum-silicosis-then-and-now
#7
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28145560/survival-following-lung-transplantation-for-artificial-stone-silicosis-relative-to-idiopathic-pulmonary-fibrosis
#8
Dror Rosengarten, Benjamin D Fox, Elizabeth Fireman, Paul D Blanc, Victoria Rusanov, Oren Fruchter, Yael Raviv, Osnat Shtraichman, Milton Saute, Mordechai R Kramer
BACKGROUND: Silicosis is a progressive lung disease resulting from the inhalation of respirable crystalline silica. Lung transplantation is the only treatment for end-stage silicosis. The aim of this study was to analyze the survival experience following lung transplantation among patients with silicosis. METHODS: We reviewed data for all patients who underwent lung transplantation for silicosis and a matched group undergoing lung transplantation for idiopathic pulmonary fibrosis (IPF) at a single medical center between March 2006 and the end of December 2013...
February 1, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28139521/association-between-genetic-variants-of-transforming-growth-factor-%C3%AE-1-and-susceptibility-of-pneumoconiosis-a-meta-analysis
#9
Chang-Wen Deng, Xing-Xing Zhang, Jin-Huan Lin, Li-Fei Huang, Yu-Lan Qu, Chong Bai
BACKGROUND: Transforming growth factor-beta 1 (TGF-β1) and gene variants have been extensively studied in various human diseases. For example, TGF-β1 polymorphisms were associated with fibrosis and pneumoconiosis, but the data remained controversial. The aim of this meta-analysis was to assess the association between TGF-β1 -509 C>T [rs1800469], +869 T>C [rs1800470], and +915 G>C [rs1800471] polymorphisms and pneumoconiosis. METHODS: A comprehensive literature search was conducted through searching in PubMed, Embase, the Chinese Biomedical Database, and the Wei Pu (Chinese) Database by the end of April 2016...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28088237/association-between-diabetes-mellitus-and-multi-drug-resistant-tuberculosis-a-protocol-for-a-systematic-review-and-meta-analysis
#10
Balewgizie Sileshi Tegegne, Tesfa Dejenie Habtewold, Melkamu Merid Mengesha, Johannes G M Burgerhof
INTRODUCTION: Multi-drug-resistant tuberculosis (MDR-TB) has emerged as a challenge to global tuberculosis (TB) control and remains a major public health concern in many countries. Diabetes mellitus (DM) is an increasingly recognized comorbidity that can both accelerate TB disease and complicate its treatment. The aim of this study is to summarize available evidence on the association of DM and MDR-TB among TB patients and to provide a pooled estimate of risks. METHODS: All studies published in English before October 2016 will be searched using comprehensive search strings through PubMed, EMBASE, Web of Science, and WHO Global Health Library databases which have reported the association of DM and MDR-TB in adults with TB (age > =15)...
January 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28062213/anti-fibrotic-effects-of-bone-morphogenetic-protein-7-modified-bone-marrow-mesenchymal-stem-cells-on-silica-induced-pulmonary-fibrosis
#11
Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu, Ximeng Lian, Piye Niu, Caixia Guo, Lin Tian
Silicosis is an occupational lung disease caused by exposure to small particles of crystalline silica, which ultimately results in diffuse pulmonary fibrosis. Evidence indicates an anti-fibrotic role of bone morphogenetic protein-7 (BMP-7) and bone marrow mesenchymal stem cells (BMSCs) in lung diseases. Therefore, strategies incorporating genetic engineering and stem cell biology might have a tremendous potential to treat critical injuries and diseases. Therefore, we modified BMSCs to overexpress the BMP-7 gene (BMP-7-BMSCs) by lentivirus transduction, and then evaluated whether fibrotic processes were inhibited by these cells in vivo...
January 4, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28054008/infodemiological-data-concerning-silicosis-in-the-usa-in-the-period-2004-2010-correlating-with-real-world-statistical-data
#12
Nicola Luigi Bragazzi, Guglielmo Dini, Alessandra Toletone, Francesco Brigo, Paolo Durando
This article reports data concerning silicosis-related web-activities using Google Trends (GT) capturing the Internet behavior in the USA for the period 2004-2010. GT-generated data were then compared with the most recent available epidemiological data of silicosis mortality obtained from the Centers for Disease Control and Prevention for the same study period. Statistically significant correlations with epidemiological data of silicosis (r=0.805, p-value <0.05) and other related web searches were found...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28051197/silicotuberculosis-with-esophagobronchial-fistula-and-broncholithiasis
#13
Hua Zhang, Li Li, Xiao-Wei Sun, Chun-Ling Zhang
A 69-year-old woman was admitted to hospital 4 times from November 2007 to June 2009. The patient had silicosis complicated by broncholithiasis, esophagobronchial fistula, and relapsed tuberculosis. She had worked as a stone crusher for 3 years and was exposed to a large amount of quartz dust. Barium esophagography, gastroesophageal endoscopy, and biopsy suggested esophageal-related chronic inflammation and ulcer, which probably caused the repeated esophagobronchial fistulas observed. Bronchoscopy revealed a free broncholithiasis in the left main bronchus...
January 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28043619/identifying-patients-at-high-risk-of-tuberculosis-recurrence
#14
Ruxana T Sadikot
Several studies have been done in relation to recurrence of tuberculosis (TB) following completion of treatment. However, recurrence of TB is still a major problem from a public health perspective in high-burden countries, where no special attention is being given to this issue. Disease recurrence is an important indicator of the efficacy of antituberculosis treatment. The rate of recurrence is highly variable and has been estimated to range from 4.9% to 25%. This variability is not only a reflection of regional epidemiology of recurrence but differences in the definitions used by the TB control programs...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28018477/differential-activation-of-raw-264-7-macrophages-by-size-segregated-crystalline-silica
#15
Steven E Mischler, Emanuele G Cauda, Michelangelo Di Giuseppe, Linda J McWilliams, Claudette St Croix, Ming Sun, Jonathan Franks, Luis A Ortiz
BACKGROUND: Occupational exposure to crystalline silica is a well-established occupational hazard. Once in the lung, crystalline silica particles can result in the activation of alveolar macrophages (AM), potentially leading to silicosis, a fibrotic lung disease. Because the activation of alveolar macrophages is the beginning step in a complicated inflammatory cascade, it is necessary to define the particle characteristics resulting in this activation. The aim of this research was to determine the effect of the size of crystalline silica particles on the activation of macrophages...
2016: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/27995130/biometric-monitoring-in-silicosis-to-detect-early-disease-and-monitor-lung-injury-not-quite-there
#16
Daniel Weiler Ravell, Hashem Bishara
Biometric monitoring in exposure to silica dust http://ow.ly/qRrB303lMDg.
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27995129/biometric-monitoring-in-silicosis-to-detect-early-disease-and-monitor-lung-injury-not-quite-there
#17
Noa Ophir, Elizabeth Fireman
Biomonitoring of artificial stone-exposed workers http://ow.ly/Ut4J304amUr.
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27992190/unveiling-the-variability-of-quartz-hazard-in-light-of-recent-toxicological-findings
#18
Cristina Pavan, Bice Fubini
The variability of quartz hazard stands as one of the most puzzling issues in particle toxicology, notwithstanding the fact that silicosis, the most ancient occupational disease, was the very topic from which the study of the toxicity of particulates developed. Over the years, other adverse effects of silica particles (i.e., lung cancer and autoimmune diseases) were detected and described. However, a few gaps are still present in the physicochemical determinants and cellular pathways involved in the mechanisms of silica pathogenicity...
December 19, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27976666/fatal-silicosis-in-a-funeral-arts-craftsman
#19
Roberto Calisti, Gianfranco Ballatori
BACKGROUND: The current scientific debate on silica and cancer has often led to overlooking the persisting risk of lung fibrosis from crystalline silica. CASE REPORT: During 2000, when 54 years old, a funeral arts' craftsman began to suffer from persistent, hacking cough; radiography and high resolution computed tomography (HRCT) showed thin sub-pleural nodulations of the lungs, mainly in the upper fields. Two years later, increasing dyspnoea appeared and HRCT revealed vast consolidative opacities in both upper fields...
December 13, 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/27965042/do-sanitary-ceramic-workers-have-a-worse-presentation-of-chest-radiographs-or-pulmonary-function-tests-than-other-ceramic-workers
#20
Yu-Chung Tsao, Su-Hsun Liu, I-Shiang Tzeng, Tsung-Han Hsieh, Jau-Yuan Chen, Jiin-Chyuan John Luo
BACKGROUND/PURPOSE: Silicosis remains the most prevalent occupational disease worldwide. There have been no specific studies focusing on the association between exposure settings at work and the clinical severity in silicosis patients. In this study, we describe and compare the clinical characteristics and silicosis-associated exposure history at work among workers from several types of ceramic production facilities in Taiwan. METHODS: We reviewed the medical records of 221 patients who were first diagnosed with silicosis at the Occupational Medicine Clinic of Northern Taiwan in 2012...
December 10, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
keyword
keyword
22295
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"