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https://www.readbyqxmd.com/read/29773095/the-role-of-fibrocyte-in-the-pathogenesis-of-silicosis
#1
Juan Li, Wu Yao, Jian Yong Hou, Lin Zhang, Lei Bao, Hui Ting Chen, Di Wang, Zhong Zheng Yue, Yi Ping Li, Miao Zhang, Xing Hao Yu, Jian Hui Zhang, Ya Qian Qu, Chang Fu Hao
Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells. Fibrocytes can differentiate into myofibroblast. Therefore, the present study was designed to investigate whether fibrocytes participate in silicosis. The rat model of silicosis was established. Hematoxylin-eosin stainings and Masson stainings were used to evaluate the histopathology and collagen deposition. Flow cytometry and immunofluorescence were performed to detect the number of fibrocytes and their contribution to myofibroblasts...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29755813/silicosis-in-turkey-is-it-an-endless-nightmare-or-is-there-still-hope
#2
REVIEW
Metin Akgün, Begüm Ergan
Silicosis is an ancient but still life-threatening occupational lung disease because of its incurable nature. Although its risks are known in many occupational settings and effective control strategies are well established, new cases, even epidemics, continue to occur in different sectors of Turkey. Before taking action, defining the magnitude of the problem is essential. In this concise review, we aimed to present the current situation of silicosis in Turkey. According to the data available to date, silicosis continues to be a major health problem in different sectors...
April 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29755467/silicosis-and-silica-induced-autoimmunity-in-the-diversity-outbred-mouse
#3
Jessica M Mayeux, Gabriela M Escalante, Joseph M Christy, Rahul D Pawar, Dwight H Kono, Kenneth M Pollard
Epidemiological studies have confidently linked occupational crystalline silica exposure to autoimmunity, but pathogenic mechanisms and role of genetic predisposition remain poorly defined. Although studies of single inbred strains have yielded insights, understanding the relationships between lung pathology, silica-induced autoimmunity, and genetic predisposition will require examination of a broad spectrum of responses and susceptibilities. We defined the characteristics of silicosis and autoimmunity and their relationships using the genetically heterogeneous diversity outbred (DO) mouse population and determined the suitability of this model for investigating silica-induced autoimmunity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29751545/exposure-to-quartz-in-finnish-workplaces-declined-during-the-first-six-years-after-the-signing-of-the-nepsi-agreement-but-evened-out-between-2013-and-2017
#4
Tapani Tuomi, Markku Linnainmaa, Sirpa Pennanen
To reduce the incidence of occupational diseases related to exposure to respirable silica at work, the main industries in the EU associated with respirable silica agreed on measures to improve working conditions through the application of good practices. These practices were included in “The Agreement on Workers Health Protection through the Good Handling and Use of Crystalline Silica and Products Containing it” (NEPSI agreement), signed in April 2006. In Finland, we have previously seen a decline in exposure to respirable quartz in relevant industries upon the treaty coming into effect, during the years 2006⁻2013...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29684394/n-acetyl-seryl-aspartyl-lysyl-proline-ac-sdkp-attenuates-silicotic-fibrosis-by-suppressing-apoptosis-of-alveolar-type-ii-epithelial-cells-via-mediation-of-endoplasmic-reticulum-stress
#5
Lijuan Zhang, Dingjie Xu, Qian Li, Yi Yang, Hong Xu, Zhongqiu Wei, Ruimin Wang, Wenli Zhang, Yan Liu, Yucong Geng, Shifeng Li, Xuemin Gao, Fang Yang
Damage to alveolar epithelial cells (AECs) caused by long-term inhalation of large amounts of silica dust plays a significant role in the pathology of silicosis. The present study was undertaken to investigate the regulatory mechanism(s) involved in type II AEC damage from silicon dioxide (SiO2 ) as well as the mechanism(s) related to the prevention of silicosis by the antifibrotic tetra peptide, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP). The 2-DE results showed that SiO2 induced endoplasmic reticulum (ER) stress in A549 cells...
April 20, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29680408/silicosis-decreases-bone-mineral-density-in-rats
#6
Zhang Hui, Xu Dingjie, Yuan Yuan, Wei Zhongqiu, Mao Na, Bei Mingjian, Gou Yu, Liu Guangyuan, Gao Xuemin, Li Shifeng, Geng Yucong, Yang Fang, Ross Summer, Xu Hong
Silicosis is the most common occupational lung disease in China, and is associated with a variety of complications, many of which are poorly understood. For example, recent data indicate that silicosis associates with the development of osteopenia, and in some cases this bone loss is severe, meeting criteria for osteoporosis. Although many factors are likely to contribute to this relationship, including a sedentary lifestyle in patients with advanced silicotic lung disease, we hypothesized that silica might directly reduce bone mineral density...
April 19, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29673857/crystalline-silica-alters-sulfatase-1-expression-in-rat-lungs-which-influences-hyper-proliferative-and-fibrogenic-effects-in-human-lung-epithelial-cells
#7
Timothy N Perkins, Paul M Peeters, Catrin Albrecht, Roel P F Schins, Mieke A Dentener, Brooke T Mossman, Emiel F M Wouters, Niki L Reynaert
Lung epithelial cells are the first cell-type to come in contact with hazardous dust materials. Upon deposition, they invoke complex reactions in attempt to eradicate particles from the airways, and repair damage. The cell surface is composed of a heterogeneous network of matrix proteins and proteoglycans, which act as scaffold and control cell-signaling networks. These functions are controlled, in part, by the sulfation patterns of heparin-sulfate proteoglycans (HSPGs), which are enzymatically regulated. Although there is evidence of altered HSPG-sulfation in idiopathic pulmonary fibrosis (IPF), this is not investigated in silicosis...
April 16, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29673394/transplantation-of-adipose-derived-mesenchymal-stem-cells-attenuates-pulmonary-fibrosis-of-silicosis-via-anti-inflammatory-and-anti-apoptosis-effects-in-rats
#8
Shangya Chen, Guanqun Cui, Cheng Peng, Martin F Lavin, Xiaoying Sun, Enguo Zhang, Ye Yang, Yingjun Guan, Zhongjun Du, Hua Shao
BACKGROUND: Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured. Recent advances in stem cell research have made possible the treatment of various diseases including lung fibrosis. The application of stem cell therapy in occupational diseases, in particular the use of adipose-derived mesenchymal stem cells (AD-MSCs) in treatment of silicosis, has not yet been reported. The aim of the study is to explore the intervening effect of silica-induced lung fibrosis in rats...
April 19, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29621588/the-rs2609255-polymorphism-in-the-fam13a-gene-is-reproducibly-associated-with-silicosis-susceptibility-in-a-chinese-population
#9
Wei Wang, Yuhui Yu, Shuangshuang Wu, Lingli Sang, Xiaohui Wang, Anni Qiu, Xiaoqiao Yu, Jingzhi Li, Lu Zhang, Min Yi, Huiting Zheng, Yuexia Gao, Jing Xiao, Yihua Lu, Liying Jiang, Yulong Lian, Xun Zhuang, Tian Tian, Minjie Chu
BACKGROUND: Two recent genome-wide association studies (GWASs) reported that the FAM13A gene at the 4q22 locus associated with pulmonary fibrosis (defined by rs2609255) overlapping with COPD (defined by rs6837671). We hypothesized that single-nucleotide polymorphisms (SNPs) related to lung disease (especially pulmonary fibrosis) identified in this region are also associated with the risk of silicosis. METHODS: To test this hypothesis, we genotyped these two SNPs (rs2609255 and rs6837671) in a case-control study including 177 silicosis cases and 204 controls with silica dust exposure years similar to the levels for cases in a Chinese population...
April 2, 2018: Gene
https://www.readbyqxmd.com/read/29620193/influence-of-the-interaction-between-ac%C3%A2-sdkp-and-ang-ii-on-the-pathogenesis-and-development-of-silicotic-fibrosis
#10
Yi Zhang, Fang Yang, Yan Liu, Hai-Bing Peng, Yu-Cong Geng, Shi-Feng Li, Hong Xu, Li-Yan Zhu, Xiu-Hong Yang, Darrell Brann
N‑acetyl‑seryl‑aspartyl‑lysyl‑proline (Ac‑SDKP) is a natural tetrapeptide that is released from thymosin β4 by prolyl oligopeptides. It is hydrolyzed by the key enzyme of the renin‑angiotensin system, angiotensin‑converting enzyme (ACE). The aim of the present study was to investigate the alterations in Ac‑SDKP and the ACE/angiotensin II (Ang II)/angiotensin II type 1 (AT1) receptor axis and its impact on the pathogenesis and development of silicotic fibrosis. For in vivo studies, a HOPE MED 8050 exposure control apparatus was used to establish different stages of silicosis in a rat model treated with Ac‑SDKP...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29610142/inflammasome-independent-leukotriene-b-4-production-drives-crystalline-silica-induced-sterile-inflammation
#11
Bindu Hegde, Sobha R Bodduluri, Shuchismita R Satpathy, Ruqaih S Alghsham, Venkatakrishna R Jala, Silvia M Uriarte, Dong-Hoon Chung, Matthew B Lawrenz, Bodduluri Haribabu
Silicosis is a lung inflammatory disease caused by chronic exposure to crystalline silica (CS). Leukotriene B4 (LTB4 ) plays an important role in neutrophilic inflammation, which drives silicosis and promotes lung cancer. In this study, we examined the mechanisms involved in CS-induced inflammatory pathways. Phagocytosis of CS particles is essential for the production of LTB4 and IL-1β in mouse macrophages, mast cells, and neutrophils. Phagosomes enclosing CS particles trigger the assembly of lipidosome in the cytoplasm, which is likely the primary source of CS-induced LTB4 production...
April 2, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29580565/pleuroparenchymal-fibroelastosis-and-silicosis-an-unexpected-association
#12
João Paulo Silva, Natália Melo, Susana Guimarães, António Morais
No abstract text is available yet for this article.
March 23, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29548652/clinical-features-of-secondary-spontaneous-pneumothorax-complicated-with-silicosis
#13
Norichika Iga, Hideyuki Nishi, Nobukazu Fujimoto, Takumi Kishimoto
BACKGROUND: Few studies have focused on the management of secondary spontaneous pneumothorax (SSP) as a complication of pneumoconiosis. The aim of this study was to investigate the clinical features and therapeutic course of SSP associated with silicosis. METHODS: Between April 2005 and March 2015, 17 patients with silicosis underwent chest tube drainage for SSP in our institution. We retrospectively analyzed patient characteristics, type of treatment, clinical course, rate of recurrence, and survival time, and compared them with those of 30 patients diagnosed with chronic obstructive pulmonary disease (COPD) during the same period...
March 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29540971/erasmus-syndrome-silicosis-and-systemic-sclerosis
#14
Shubhra Jain, Vinod Joshi, Yogendra S Rathore, Narendra Khippal
Several occupational hazards, especially exposure to silica, have been implicated as causal factors for the development of scleroderma-like disorders. Compared to other connective tissue disorders, silica-associated systemic sclerosis (SA-SS) is relatively rare. Silica-induced scleroderma is indistinguishable from idiopathic systemic sclerosis. However, the former expresses a high predisposition of pulmonary involvement and anti-Scl-70 antibody. We report the case of a 42-year-old male, stone cutter by occupation, who was diagnosed as simple chronic silicosis and developed systemic sclerosis...
May 2017: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29540674/circhectd1-promotes-the-silica-induced-pulmonary-endothelial-mesenchymal-transition-via-hectd1
#15
Shencun Fang, Huifang Guo, Yusi Cheng, Zewei Zhou, Wei Zhang, Bing Han, Wei Luo, Jing Wang, Weiping Xie, Jie Chao
Excessive proliferation and migration of fibroblasts contribute to pulmonary fibrosis in silicosis, and both epithelial cells and endothelial cells participate in the accumulation of fibroblasts via the epithelial-mesenchymal transition (EMT) and the endothelial-mesenchymal transition (EndMT), respectively. A mouse endothelial cell line (MML1) was exposed to silicon dioxide (SiO2 , 50 μg/cm2 ), and immunofluorescence and western blot analyses were performed to evaluate levels of specific endothelial and mesenchymal markers and to elucidate the mechanisms by which SiO2 induces the EndMT...
March 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29537413/death-in-the-new-town-edinburgh-s-hidden-story-of-stonemasons-silicosis
#16
K Donaldson, W A Wallace, C Henry, A Seaton
The building of the Edinburgh New Town, from the mid-18th to the mid-19th centuries, was a major advance in harmonious and elegant town planning. However, there is anecdotal evidence that it led to the occurrence of an epidemic of silicosis/tuberculosis among the stonemasons. We have reviewed contemporary accounts of the episode and early records of the understanding of silicosis. We have also studied the lung of a contemporary stonemason, preserved in the museum of the Royal College of Surgeons of Edinburgh, and confirmed the presence of silico-tuberculosis in it...
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29516879/patients-at-high-risk-of-tuberculosis-recurrence
#17
REVIEW
Mehdi Mirsaeidi, Ruxana T Sadikot
Recurrent tuberculosis (TB) continues to be a significant problem and is an important indicator of the effectiveness of TB control. Recurrence can occur by relapse or exogenous reinfection. Recurrence of TB is still a major problem in high-burden countries, where there is lack of resources and no special attention is being given to this issue. The rate of recurrence is highly variable and has been estimated to range from 4.9% to 47%. This variability is related to differences in regional epidemiology of recurrence and differences in the definitions used by the TB control programs...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29481578/silica-exposure-increases-the-risk-of-stroke-but-not-myocardial-infarction-a-retrospective-cohort-study
#18
Chenjing Fan, Pål Graff, Per Vihlborg, Ing-Liss Bryngelsson, Lena Andersson
INTRODUCTION: Work-related exposure to silica is a global health hazard that causes diseases such as silicosis. Some studies have also reported that silica exposure is linked to elevated cardiovascular disease mortality. However, these diagnoses have not been investigated in detail and there have been few studies on morbidity. The aim of this study is to examine morbidity and mortality from different cardiovascular diseases among silica-exposed Swedish foundry workers. METHODS: Historical and contemporary measurements (1968-2006) of respiratory silica exposure were matched to job categories, individual foundries, and 4 time periods (1968-1979, 1980-1989, 1990-1999, 2000-2006) using a mixed model...
2018: PloS One
https://www.readbyqxmd.com/read/29480834/percutaneous-treatment-for-silicosis-induced-pulmonary-artery-stenosis-a-case-report-and-review-of-the-literature
#19
REVIEW
Ruifeng Zhang, Guofeng Ma, Xiaoling Xu, Li Liang
BACKGROUND: Exposure to crystalline silica results in silicosis with initiation and progression of pulmonary fibrosis. The impaired lung parenchyma leads to pulmonary arterial hypertension and increased pressure in the right ventricle of the heart. Usually, the silicosis may be followed by enlargement of hilar lymphnodes, but silicosis-induced pulmonary artery stenosis with severe pulmonary hypertension is rare. Percutaneous pulmonary artery stenting and balloon angioplasty were performed to relieve stenosis and pulmonary hypertension...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29401612/silica-induced-initiation-of-circular-zc3h4-rna-zc3h4-pathway-promotes-the-pulmonary-macrophage-activation
#20
Xiyue Yang, Jing Wang, Zewei Zhou, Rong Jiang, Jie Huang, Lulu Chen, Zhouli Cao, Han Chu, Bing Han, Yusi Cheng, Jie Chao
Phagocytosis of silicon dioxide (SiO2 ) into lung cells causes an inflammatory cascade that results in fibroblast proliferation and migration, followed by fibrosis. Circular RNAs (circRNAs) are a subclass of noncoding RNAs that are present within mammalian cells; however, researchers have not determined whether circRNAs are involved in the pathophysiologic process of silicosis. To elucidate the role of these RNAs in SiO2 -induced inflammation in pulmonary macrophages, we investigated the upstream molecular mechanisms and functional effects of circRNAs on cell apoptosis, proliferation, and migration...
January 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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