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https://www.readbyqxmd.com/read/27894297/pulmonary-hypertension-and-vascular-remodeling-in-mice-exposed-to-crystalline-silica
#1
Igor N Zelko, Jianxin Zhu, Jeffrey D Ritzenthaler, Jesse Roman
BACKGROUND: Occupational and environmental exposure to crystalline silica may lead to the development of silicosis, which is characterized by inflammation and progressive fibrosis. A substantial number of patients diagnosed with silicosis develop pulmonary hypertension. Pulmonary hypertension associated with silicosis and with related restrictive lung diseases significantly reduces survival in affected subjects. An animal model of silicosis has been described previously however, the magnitude of vascular remodeling and hemodynamic effects of inhaled silica are largely unknown...
November 28, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27866552/-silicosis-with-tracheobronchopathia-osteochondroplastica-one-case-report
#2
N Wu, Q Ye, L L Xu
No abstract text is available yet for this article.
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866541/-influencing-factors-for-postoperative-survival-of-patients-with-stage-iii-silicosis-treated-by-lung-transplantation
#3
W J Mao, X W Nie, W Xia, M F Zheng, R Chen, Y J He, F Liu, S G Ye, R G Lu, J Y Chen
Objective: To investigate the clinical effect, postoperative complications, and causes of death in the treatment of stage III silicosis with lung transplantation and the influencing factors for survival. Methods: A retrospective analysis was performed for the clinical data of 32 patients with stage III silicosis who underwent lung transplantation in our hospital from September 2002 to September 2015. The survival, causes of death, and postoperative complications were analyzed. The Kaplan-Meier method was used to plot survival curves, the log-rank test was used to compare the influence of each factor on survival rates, and the multivariate Cox proportional hazards regression model was used to evaluate the influence of each factor on survival...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866190/role-of-mcpip1-in-the-endothelial-mesenchymal-transition-induced-by-silica
#4
Jie Chao, Xingang Wang, Yuxia Zhang, Tiebing Zhu, Wei Zhang, Zewei Zhou, Jian Yang, Bing Han, Yusi Cheng, Xiaojie Tu, Honghong Yao
BACKGROUND: Silicosis is characterized by the accumulation of fibroblasts and the excessive deposition of extracellular matrix. Fibroblast generation via endothelial-mesenchymal transition (EndMT) is one process responsible for this accumulation of fibroblasts. However, the mechanisms underlying EndMT remain unknown. METHODS: Human umbilical vein endothelial cells (HUVECs) were exposed to SiO2 (50 µg/cm2). Specific endothelial and mesenchymal markers were evaluated using immunofluorescence and western blot analysis...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27865796/bletilla-striata-medicinal-uses-phytochemistry-and-pharmacological-activities
#5
REVIEW
Xirui He, Jiacheng Fang, Xiaoxiao Wang, Zefeng Zhao, Yu Chang, Hao Guo, Linhong Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Bletilla striata (Thunb.) Reichb. f. (Orchidaceae), also known as Hyacinth Orchid and Baiji (Simplified Chinese: ), not only has been widely used for the treatment of hematemesis, hemoptysis, and traumatic bleeding due to the efficacy of arresting bleeding with astringent action, but also has been applied topically to overcome ulcers, sores, swellings, and chapped skin due to the efficacy of dispersing swelling and promoting tissue regeneration. Additional medical applications include the treatment of tuberculosis, malignant ulcers, hemorrhoids, anthrax, eye diseases, and silicosis...
November 16, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27843169/silicosis-and-silicotuberculosis-in-india
#6
Nandini Sharma, Debashish Kundu, Sunita Dhaked, Anand Das
No abstract text is available yet for this article.
October 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27833322/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-a-rare-case-of-carcinoma-stomach-with-concomitant-silicosis
#7
Arun Sasikumar, Ajith Joy, Madhavan Unni, Jayaprakash Madhavan
The role of fluorine-18 fluorodeoxyglucose. ((18)F-FDG) positron emission tomography. (PET)/computed tomography. (CT) in the initial staging of various malignancies is now well established. However, nonspecificity of FDG occasionally results in tracer uptake in benign lung lesions. The authors describe a complicated case of carcinoma stomach with multiple nodules and a cavitary lesion in lungs where (18)F-FDG PET CT done for initial staging revealed FDG avid mass in stomach, FDG avid multiple mediastinal lymph nodes and multiple intensely FDG avid bilateral lung lesions...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27815873/single-cell-analysis-of-phagocytosis-phagosome-maturation-phagolysosomal-leakage-and-cell-death-following-exposure-of-macrophages-to-silica-particles
#8
Gaurav N Joshi, Renée M Gilberti, David A Knecht
Chronic inhalation of silica in various occupational settings results in the development of silicosis, a disease characterized by lung fibrosis. Uptake of silica particles by alveolar macrophages results in cell death and this is one of the contributing factors to the development of silicosis. We have characterized the uncoated or protein-coated (non-opsonized) and Fc receptor-mediated (antibody-opsonized) routes of silica phagocytosis and toxicity. Numerous microscopy techniques and fluorescent probes are outlined in this chapter to carefully measure particle uptake, by macrophages, phagosome maturation, phagosomal reactive oxygen species generation, phagolysosomal leakage, and cell death...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27814719/occupational-exposure-to-silica-dust-and-risk-of-lung-cancer-an-updated-meta-analysis-of-epidemiological-studies
#9
Satiavani Poinen-Rughooputh, Mahesh Shumsher Rughooputh, Yanjun Guo, Yi Rong, Weihong Chen
BACKGROUND: Crystalline silica is considered as one of the most common and serious occupational hazards to workers' health. Although its association with lung cancer has been studied for many decades, the conclusion remains somewhat controversial. Our objectives are to review and summarize the epidemiological evidence on the relationship between occupational silica exposure and risk of lung cancer and to provide an update on this major occupational health concern. METHODS: Eligible studies up to 29 April 2016 were identified...
November 4, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27808662/elemental-properties-of-coal-slag-and-measured-airborne-exposures-at-two-coal-slag-processing-facilities
#10
Christopher Mugford, Randy Boylstein, Jenna L Gibbs
In 1974, the National Institute for Occupational Safety and Health recommended a ban on the use of silica sand abrasives containing >1% silica due to the risk of silicosis. This gave rise to substitutes including coal slag. An Occupational Safety and Health Administration investigation in 2010 uncovered a case cluster of suspected pneumoconiosis in four former workers at a coal slag processing facility in Illinois, possibly attributable to occupational exposure to coal slag dust. This article presents the results from a National Institute for Occupational Safety and Health industrial hygiene survey at the same coal slag processing facility and a second facility...
November 3, 2016: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27806115/leveraging-big-data-for-exploring-occupational-diseases-related-interest-at-the-level-of-scientific-community-media-coverage-and-novel-data-streams-the-example-of-silicosis-as-a-pilot-study
#11
Nicola Luigi Bragazzi, Guglielmo Dini, Alessandra Toletone, Francesco Brigo, Paolo Durando
OBJECTIVE: Silicosis is an untreatable but preventable occupational disease, caused by exposure to silica. It can progressively evolve to lung impairment, respiratory failure and death, even after exposure has ceased. However, little is known about occupational diseases-related interest at the level of scientific community, media coverage and web behavior. This article aims at filling in this gap of knowledge, taking the silicosis as a case study. METHODS: We investigated silicosis-related web-activities using Google Trends (GT) for capturing the Internet behavior worldwide in the years 2004-2015...
2016: PloS One
https://www.readbyqxmd.com/read/27803925/effect-of-xinjiang-uyghur-vernonia-anthelmintica-willd-injection-treatment-with-silicosis-fibrosis
#12
Guitao Liu, Yingjia Liu, Lu Jin, Cuidong Li, Liping Nie, Yanhua Wei, Wenyu Wang, Yuhong Xu, Nuziguli Nusilaiti, Ping Hua, Xiujuan Li, Xiaohua Wang, Wenlong Wei, Hamulati Wufuer
Objective. To observe the curative effect of VAWI on Xinjiang Uygur patients with silicosis fibrosis. Methods. After we diagnosed the 40 patients with the first phase of silicosis, we randomly divided them into two groups: the basic treatment group (group A, n = 20) and the VAWI group (group B, n = 20). At the same time, we selected the age-matched healthy patients (n = 20). We applied the combined protein chip with SELDI-TOF-MS to carry out the serum analysis. The data were analyzed throughout data preprocessing, difference in PEAK screening, hierarchical cluster analysis, and Principal Component Analysis (PCA)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27782836/macrophage-derived-mcpip1-mediates-silica-induced-pulmonary-fibrosis-via-autophagy
#13
Haijun Liu, Shencun Fang, Wei Wang, Yusi Cheng, Yingming Zhang, Hong Liao, Honghong Yao, Jie Chao
BACKGROUND: Silicosis is characterized by accumulation of fibroblasts and excessive deposition of extracellular matrix. Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) plays a critical role in fibrosis induced by SiO2. However, the details of the downstream events of MCPIP1 activity in pulmonary fibrosis remain unclear. To elucidate the role of MCPIP1-induced autophagy in SiO2-induced fibrosis, both the upstream molecular mechanisms and the functional effects of SiO2 on cell apoptosis, proliferation and migration were investigated...
October 25, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27775689/earthworm-extract-attenuates-silica-induced-pulmonary-fibrosis-through-nrf2-dependent-mechanisms
#14
Jingjin Yang, Ting Wang, Yan Li, Wenxi Yao, Xiaoming Ji, Qiuyun Wu, Lei Han, Ruhui Han, Weiwen Yan, Jiali Yuan, Chunhui Ni
Silicosis is an occupational pulmonary fibrosis caused by inhalation of silica (SiO2) and there are no ideal drugs to treat this disease. Earthworm extract (EE), a natural nutrient, has been reported to have anti-inflammatory, antioxidant, and anti-apoptosis effects. The purpose of the current study was to test the protective effects of EE against SiO2-induced pulmonary fibrosis and to explore the underlying mechanisms using both in vivo and in vitro models. We found that treatment with EE significantly reduced lung inflammation and fibrosis and improved lung structure and function in SiO2-instilled mice...
October 24, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27769022/tadalafil-reduces-airway-hyperactivity-and-protects-against-lung-and-respiratory-airways-dysfunction-in-a-rat-model-of-silicosis
#15
Rania R Abdelaziz, Wagdi F Elkashef, Eman Said
Silicosis is a crippling respiratory disorder characterized by massive lung inflammation and fibrosis. The current study provides evidence on the protective potential of tadalafil; a specific phosphodiesterase-5 (PDE-5) inhibitor against experimentally-induced pulmonary silicosis in rats. Silicosis was induced by intranasal instillation of crystalline silica (50mg/rat). Halofuginone hydrobromide; a standard collagen-1 synthesis inhibitor was selected as a reference anti-fibrotic. Daily oral administration of tadalafil (1mg/kg) for 8weeks significantly ameliorated silica-induced pulmonary damage...
October 18, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27764010/endobronchial-silicosis-and-tuberculosis-presenting-as-the-right-middle-lobe-syndrome
#16
James J Anderson, Kwun M Fong, David B Godbolt, Steven C Leong, Henry M Marshall
No abstract text is available yet for this article.
October 2016: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/27748907/emodin-suppresses-silica-induced-lung-fibrosis-by-promoting-sirt1-signaling-via-direct-contact
#17
Tian Yang, Jinyuan Wang, Yamei Pang, Xiaomin Dang, Hui Ren, Ya Liu, Mingwei Chen, Dong Shang
Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains to be fully elucidated Emodin shows antifibrotic effects in several organs with fibrosis, however, it has not been investigated in pulmonary silicosis. In the present study, the possible mechanism of lung fibrosis and the antifibrotic effect of emodin in silica inhalation‑induced lung fibrosis were investigated. Pulmonary silica particle inhalation was used to induce lung fibrosis in mice...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27736836/surveillance-for-silicosis-michigan-and-new-jersey-2003-2011
#18
Patricia L Schleiff, Jacek M Mazurek, Mary Jo Reilly, Kenneth D Rosenman, Martha B Yoder, Margaret E Lumia, Karen Worthington
CDC's National Institute for Occupational Safety and Health (NIOSH), state health departments, and other state entities maintain a state-based surveillance program of confirmed silicosis cases. Data on confirmed cases are collected and compiled by state entities and submitted to CDC. This report summarizes information for cases of silicosis that were reported to CDC for 2003-2011 by Michigan and New Jersey, the only states that continue to provide data voluntarily to NIOSH. The data for this report were final as of January 8, 2015...
October 14, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27730180/artificial-stone-dust-induced-functional-and-inflammatory-abnormalities-in-exposed-workers-monitored-quantitatively-by-biometrics
#19
Noa Ophir, Amir Bar Shai, Yifat Alkalay, Shani Israeli, Rafi Korenstein, Mordechai R Kramer, Elizabeth Fireman
The manufacture of kitchen and bath countertops in Israel is based mainly on artificial stone that contains 93% silica as natural quartz, and ∼3500 workers are involved in cutting and processing it. Artificial stone produces high concentrations of silica dust. Exposure to crystalline silica may cause silicosis, an irreversible lung disease. Our aim was to screen exposed workers by quantitative biometric monitoring of functional and inflammatory parameters. 68 exposed artificial stone workers were compared to 48 nonexposed individuals (controls)...
January 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27719977/imaging-of-occupational-lung-disease
#20
Jay Champlin, Rachael Edwards, Sudhakar Pipavath
Occupational lung diseases span a variety of pulmonary disorders caused by inhalation of dusts or chemical antigens in a vocational setting. Included in these are the classic mineral pneumoconioses of silicosis, coal worker's pneumoconiosis, and asbestos-related diseases as well as many immune-mediated and airway-centric diseases, and new and emerging disorders. Although some of these have characteristic imaging appearances, a multidisciplinary approach with focus on occupational exposure history is essential to proper diagnosis...
November 2016: Radiologic Clinics of North America
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