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https://www.readbyqxmd.com/read/29782839/different-regulation-of-cortisol-and-corticosterone-in-the-subterranean-rodent-ctenomys-talarum-responses-to-dexamethasone-angiotensin-ii-potassium-and-diet
#1
Federico Vera, C Daniel Antenucci, Roxana R Zenuto
When harmful environmental stimuli occur, glucocorticoids (GCs), cortisol and corticosterone are currently used to evaluate stress status in vertebrates, since their secretions are primarily associated to an increased activity of the hypothalamic-pituitary-adrenal (HPA) axis. To advance in our comprehension about GCs regulation, we evaluated the subterranean rodent Ctenomys talarum to assess cortisol and corticosterone response to (1) the negative feedback of the HPA axis using the dexamethasone (DEX) suppression test, (2) angiotensin II (Ang II), (3) potassium (K+ ) intake, and (4) different diets (vegetables, grasses, acute fasting)...
May 18, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29754134/surprising-pathological-and-clinical-manifestations-of-miliary-tuberculosis
#2
Kamonkiat Wirunsawanya, Dennis Thomas Bolger
We report a surprising pathological finding of miliary tuberculosis (TB) in a 49-year-old Chuukese, immunocompetent woman who was initially admitted to the hospital for a 1-month duration of chronic abdominal pain and intermittent fevers. Her clinical symptoms did not improve despite treatment with vancomycin and piperacillin-tazobactam. Based on the primary abdominal CT findings suggesting advanced ovarian cancer with omental metastatic disease, further workup with omental core biopsy was performed and demonstrated acute neutrophilic necrosis without malignant cells or granulomata...
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29742365/association-between-obstructive-sleep-apnea-and-cardiovascular-risk-factors-variation-by-age-sex-and-race-the-multi-ethnic-study-of-atherosclerosis-mesa
#3
Glaucylara Reis Geovanini, Rui Wang, Jia Weng, Nancy S Jenny, Steven Shea, Matthew Allison, Peter Libby, Susan Redline
RATIONALE: The association between obstructive sleep apnea (OSA) and cardiovascular disease (CVD) is complex, bi-directional, and may vary across groups. Understanding what cardiovascular risk factors vary in their relationship to OSA across population groups may improve the knowledge of the OSA-related CVD susceptibility. OBJECTIVE: To better understand the heterogeneity of associations, we assessed whether associations of OSA with cardiovascular risk factors vary by age, sex, and race/ethnicity...
May 9, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29719821/the-physiopathological-role-of-the-exchangers-belonging-to-the-slc37-family
#4
REVIEW
Anna Rita Cappello, Rosita Curcio, Rosamaria Lappano, Marcello Maggiolini, Vincenza Dolce
The human SLC37 gene family includes four proteins SLC37A1-4, localized in the endoplasmic reticulum (ER) membrane. They have been grouped into the SLC37 family due to their sequence homology to the bacterial organophosphate/phosphate (Pi) antiporter. SLC37A1-3 are the less characterized isoforms. SLC37A1 and SLC37A2 are Pi-linked glucose-6-phosphate (G6P) antiporters, catalyzing both homologous (Pi/Pi) and heterologous (G6P/Pi) exchanges, whereas SLC37A3 transport properties remain to be clarified. Furthermore, SLC37A1 is highly homologous to the bacterial glycerol 3-phosphate permeases, so it is supposed to transport also glycerol-3-phosphate...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29678851/improved-diagnostic-and-prognostic-power-of-combined-delta-neutrophil-index-and-mean-platelet-volume-in-pediatric-sepsis
#5
Minjeong Nam, Byeong Hei Son, Jung Eun Seo, Il Ry Kim, Chee Kyoung Park, Hyun Kyung Kim
This study aims to evaluate the diagnostic and prognostic significance of white blood cell (WBC) and platelet parameters measured by automated hematology analyzers in pediatric sepsis. The study included 232 pediatric patients whose C-reactive protein test had been requested for evaluation of infection or inflammation at a pediatric tertiary hospital. The patients were allocated to control, systemic inflammatory response syndrome (SIRS) without infection, and sepsis groups. An ADVIA 2120i hematology system was used to measure the delta neutrophil index (DN) and platelet parameters including platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and immature platelet fraction (IPF)...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678633/preanalytical-phase-effects-of-water-ingestion-during-fasting-on-routine-hematological-parameters-in-a-small-cohort-of-young-women
#6
G Unger, S F Benozzi, A Campion, G L Pennacchiotti
BACKGROUND: We analyze the effects of water ingestion before blood extraction on routine hematological parameters. METHODS: Twenty female volunteers -mean 24 y- were included. Blood was collected after a 12 h fast period (T0 ) and 1 h after the ingestion of 300 ml water (T1 ). These parameters were analyzed: white blood cell (WBC) count; WBC differential count including lymphocytes (lym), monocytes (mono), neutrophils, eosinophils (eos), and basophils; red blood cell (RBC) count; hematocrit (hct); hemoglobin (hgb); mean cell volume; mean cell hemoglobin; RBC distribution width; and platelet count (plt)...
April 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29644919/high-neutrophil-lymphocyte-ratio-in-schizophrenia-independent-of-infectious-and-metabolic-parameters
#7
Rabia Nazik Yüksel, Irem Ekmekci Ertek, Asiye Uğraş Dikmen, Erol Göka
BACKGROUND: Immunological and inflammatory mechanisms play an important role in schizophrenia. In the literature, there are studies investigating neutrophil-lymphocyte ratio (NLR) association with schizophrenia. AIMS: The purpose of this study was to compare NLR values between patients with schizophrenia and healthy controls. In addition, the study aimed to investigate the relationship between NLR and disease severity and some metabolic/inflammatory parameters. METHODS: Fifty-two patients diagnosed with schzophrenia and 53 healthy controls were included in the study...
April 12, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29630122/analysis-of-the-correlation-between-the-neutrophil-lymphocyte-ratio-in-peripheral-blood-and-perioperative-myocardial-damage-in-pediatric-patients-with-frequent-ventricular-premature-beat
#8
J Tian, X-J An, L Niu
OBJECTIVE: The objective of the present study was to investigate the relationship between the neutrophil-lymphocyte ratio (NLR) in peripheral blood and myocardial damage in pediatric patients with frequent ventricular premature beat (FVPB), and provide a reference for myocardial preservation in these patients. PATIENTS AND METHODS: A total of 212 pediatric patients who were treated in the Department of Cardiology, Xuzhou Children's Hospital between December 2014 and March 2016 for FVPB, were selected...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29590639/neutrophil-specific-knockout-demonstrates-a-role-for-mitochondria-in-regulating-neutrophil-motility-in-zebrafish
#9
Wenqing Zhou, Lingyan Cao, Jacob Jeffries, Xiaoguang Zhu, Christopher J Staiger, Qing Deng
Neutrophils are fast-moving cells essential for host immune functions. Although they primarily rely on glycolysis for ATP, isolated primary human neutrophils depend on mitochondrial membrane potential for chemotaxis. However, it is not known whether mitochondria regulate neutrophil motility in vivo , and the underlying molecular mechanisms remain obscure. Here, we visualized mitochondria in an interconnected network that localizes to the front and rear of migrating neutrophils using a novel transgenic zebrafish line...
March 28, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29553513/isolation-and-characterization-of-neutrophil-derived-microparticles-for-functional-studies
#10
Ariel Finkielsztein, Lorraine Mascarenhas, Veronika Butin-Israeli, Ronen Sumagin
Polymorphonuclear neutrophil-derived microparticles (PMN)-MPs) are lipid bilayer, spherical microvesicles with sizes ranging from 50-1,000 nm in diameter. MPs are a newly evolving, important part of cell-to-cell communication and signaling machinery. Because of their size and the nature of their release, until recently MP existence was overlooked. However, with improved technology and analytical methods their function in health and disease is now emerging. The protocols presented here are aimed at isolating and characterizing PMN-MPs by flow cytometry and immunoblotting...
March 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29527790/immune-cell-and-cytokine-patterns-in-children-with-type-1-diabetes-mellitus-undergoing-a-remission-phase-a-longitudinal-study
#11
Ana Laura Fitas, Catarina Martins, Luís Miguel Borrego, Lurdes Lopes, Anne Jörns, Sigurd Lenzen, Catarina Limbert
OBJECTIVE: Type 1 diabetes (T1D) develops in distinct stages, before and after disease onset. Whether the natural course translates into different immunologic patterns is still uncertain. This study aimed at identifying peripheral immune patterns at key time-points, in T1D children undergoing remission phase. METHODS: Children with new-onset T1D and healthy age and gender-matched controls were recruited at a pediatric hospital. Peripheral blood samples were evaluated by flow cytometry at 3 longitudinal time-points: onset (T1), remission phase (T2) and established disease (T3)...
March 12, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29524483/elevated-serum-ferritin-concentration-is-associated-with-incident-type-2-diabetes-mellitus-in-a-chinese-population-a-prospective-cohort-study
#12
Ling Chen, Yufeng Li, Fang Zhang, Simin Zhang, Xianghai Zhou, Linong Ji
AIMS: We aimed to evaluate the association between serum ferritin levels and incident type 2 diabetes mellitus risk in a Chinese population. METHODS: This cohort study assessed 2225 Chinese individuals aged 25-75 years. Diabetes mellitus was diagnosed using the 1999 World Health Organization definition with a median follow-up period of 20 months. Cox proportional hazard models were used to estimate adjusted hazard ratios and 95% confidence intervals (CI) for incident diabetes when serum ferritin concentrations increased by one standard deviation...
May 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29516256/utility-of-c-reactive-protein-as-predictive-biomarker-of-anastomotic-leak-after-minimally-invasive-esophagectomy
#13
Emanuele Asti, Gianluca Bonitta, Matteo Melloni, Stefania Tornese, Pamela Milito, Andrea Sironi, Elena Costa, Luigi Bonavina
BACKGROUND: Early detection of anastomotic leakage after esophagectomy has the potential to reduce morbidity and mortality. Prompt suspicion of leak may help to exclude patients from fast-track protocols, thereby avoiding early oral feeding and early hospital discharge which could aggravate the prognosis of a clinically occult leak. PATIENTS AND METHODS: Observational retrospective cohort study. Patients with diagnosis of esophageal cancer who underwent elective minimally invasive esophagectomy were included...
March 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29513908/new-flow-cytometry-based-method-for-the-assessment-of-the-antibacterial-effect-of-immune-cells-and-subcellular-particles
#14
Ákos M Lőrincz, Viktória Szeifert, Balázs Bartos, Erzsébet Ligeti
Techniques currently used for assessment of bacterial count or growth are time-consuming, offer low throughput, or they are complicated or expensive. The aim of the present work was to elaborate a new method that is able to detect the antibacterial effect of cells, subcellular particles, and soluble compounds in a fast, cost, and labor effective way. Our proposed technique is based on flow cytometry (FC) optimized for detection of small particles and on fluorescently labeled bacteria. It allows direct determination of the bacterial count in 3 hours...
May 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29506649/neutrophil-generated-hocl-leads-to-non-specific-thiol-oxidation-in-phagocytized-bacteria
#15
Adriana Degrossoli, Alexandra Müller, Kaibo Xie, Jannis F Schneider, Verian Bader, Konstanze F Winklhofer, Andreas J Meyer, Lars I Leichert
Phagocytic immune cells kill pathogens in the phagolysosomal compartment with a cocktail of antimicrobial agents. Chief among them are reactive species produced in the so-called oxidative burst. Here, we show that bacteria exposed to a neutrophil-like cell line experience a rapid and massive oxidation of cytosolic thiols. Using roGFP2-based fusion probes, we could show that this massive breakdown of the thiol redox homeostasis was dependent on phagocytosis, presence of NADPH oxidase and ultimately myeloperoxidase...
March 6, 2018: ELife
https://www.readbyqxmd.com/read/29500831/mediation-analysis-of-systemic-inflammation-on-the-association-between-periodontitis-and-glycaemic-status
#16
Kitti Torrungruang, Boonsong Ongphiphadhanakul, Supawadee Jitpakdeebordin, Somchai Sarujikumjornwatana
AIM: This cross-sectional study investigated the associations between periodontitis, systemic inflammation and glycaemic status. MATERIALS AND METHODS: The participants were divided into three groups: normoglycaemia, impaired fasting glucose (IFG) and diabetes. Multinomial logistic regression was used to examine the associations between periodontitis severity and glycaemic status, adjusting for potential confounders. Mediation analysis of four systemic inflammatory biomarkers, C-reactive protein (CRP), white blood cell count (WBC), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), was performed...
May 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29492362/clozapine-improvement-of-negative-symptoms-of-schizophrenia
#17
Afaque H Khan, Samina Zaidi
We report five cases of treatment-resistant schizophrenia that presented with prominent negative and positive symptoms. They fulfill the criteria of diagnosis of schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). They showed lack of response despite receiving multiple trials of first and second generation psychotropic agents. We decided to give these patients a trial of clozapine to improve their negative and positive symptoms as well as their quality of life...
December 20, 2017: Curēus
https://www.readbyqxmd.com/read/29492060/neutrophil-lymphocyte-ratio-nlr-a-well-assessment-tool-of-glycemic-control-in-type-2-diabetic-patients
#18
Mazhar Hussain, Muhammad Zafar Majeed Babar, Lubna Akhtar, Muhammad Shahbaz Hussain
Background and Objective: Increased neutrophil lymphocyte ratio (NLR) is a marker as well as predictor of various cardiac and non cardiac disorders. Our aim was to assess the relationship between NLR and different level of glycemic control in type 2 diabetic patients. Methods: An observational study was conducted at diabetic clinic of Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from September 2016 to February 2017 in which 330 type 2 diabetic patients were randomly divided in to three groups based upon diabetes control according to ADA criteria...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29473432/human-neutrophil-lipocalin-hnl-as-a-biomarker-of-acute-infections
#19
Per Venge
The early and accurate discrimination between bacterial and viral causes of acute infections is the key to a better use of antibiotics and will help slow down the fast-growing resistance to commonly used antibiotics. This discrimination is in the vast majority of cases possible to achieve by blood assay of the biomarker human neutrophil lipocalin (HNL), which we showed to be uniquely increased in patients suffering from bacterial infections. In serum, sensitivities and specificities of >90% are achieved in both adults and children...
March 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29456701/correlation-between-cortisol-levels-and-concurrent-infection-for-hepatitis-b-cirrhosis-patients-and-countermeasure-analysis
#20
Jian Zhang, Junwei Ma, Hongxin Wang, Junhong Li
The study assessed the correlation between cortisol (COR) levels and concurrent infection for the patients with hepatitis B cirrhosis for corresponding countermeasure analysis. In total, 86 patients with hepatitis B cirrhosis (non-infection group) and 32 patients with hepatitis B cirrhosis complicated with infection (infection group) who were diagnosed and treated in the Beijing YouAn Hospital from March 2014 to March 2017 were selected. The fasting venous blood of all the patients was drawn to detect COR, cortisol binding globulin (CBG), blood routine indexes, C-reactive protein (CRP), procalcitonin (PCT), endotoxin and other indicators...
March 2018: Experimental and Therapeutic Medicine
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