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https://www.readbyqxmd.com/read/29291035/the-potential-use-of-physical-resilience-to-predict-healthy-aging
#1
REVIEW
Anna Schorr, Christy Carter, Warren Ladiges
Physical resilience is the ability of an organism to respond to stressors that acutely disrupt normal physiological homeostasis. By definition, resilience decreases with increasing age, while frailty, defined as a decline in tissue function, increases with increasing age. Assessment of resilience could therefore be an informative early paradigm to predict healthy aging compared to frailty, which measures late life dysfunction. Parameters for resilience in the laboratory mouse are not yet well defined, and no single standardized stress test exists...
2018: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/29262362/interaction-of-monomeric-interleukin-8-with-cxcr1-mapped-by-proton-detected-fast-mas-solid-state%C3%A2-nmr
#2
Sang Ho Park, Sabrina Berkamp, Jasmina Radoicic, Anna A De Angelis, Stanley J Opella
The human chemokine interleukin-8 (IL-8; CXCL8) is a key mediator of innate immune and inflammatory responses. This small, soluble protein triggers a host of biological effects upon binding and activating CXCR1, a G protein-coupled receptor, located in the cell membrane of neutrophils. Here, we describe 1H-detected magic angle spinning solid-state NMR studies of monomeric IL-8 (1-66) bound to full-length and truncated constructs of CXCR1 in phospholipid bilayers under physiological conditions. Cross-polarization experiments demonstrate that most backbone amide sites of IL-8 (1-66) are immobilized and that their chemical shifts are perturbed upon binding to CXCR1, demonstrating that the dynamics and environments of chemokine residues are affected by interactions with the chemokine receptor...
December 19, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29231608/-influence-of-electroacupuncture-pretreatment-on-intestinal-function-in-the-patients-of-colorectal-cancer-surgery
#3
Sicong Mai, Jinhai Meng, Wenjuan Wang, Shuhui Lang
OBJECTIVE: To observe the effects of electroacupuncture (EA) pretreatment on the intestinal function, inflammatory reaction and blood lactic acid in the patients of colorectal cancer surgery. METHODS: Sixty patients of colorectal cancer laparotomy at selective period, aged from 18 to 59 years old were selected. According toⅠ-Ⅲ grade of American Society of Anesthesiologists (ASA), the patients were randomized into group A (total intravenous anesthesia), group B[total intravenous anesthesia combined with EA pretreatment at Zusanli (ST 36), Shangjuxu (ST 37) and Xiajuxu (ST 39) on the right side] and group C[total intravenous anesthesia combined with EA pretreatment at Zhongwan (CV 12), Tianshu (ST 25), Zusanli (ST 36), Shangjuxu (ST 37) and Xiajuxu (ST 39) on the right side], 20 cases in each one...
May 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29209116/gastric-xanthelasma-and-metabolic-disorders-a-large-retrospective-study-among-chinese-population
#4
Yi Chen, Xin-Jue He, Min-Jian Zhou, You-Ming Li
AIM: To gain knowledge of xanthelasma, a large population-based study was conducted. METHODS: Patients who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China during Jan 2009 to Nov 2016 were included. General characteristics as well as clinical data were collected, including blood routine, serum biochemical analysis, endoscopic findinds, histological evaluation and comorbiditie. Statistical analyses was performed using SPSS 20...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29162744/atp-promotes-the-fast-migration-of-dendritic-cells-through-the-activity-of-pannexin-1-channels-and-p2x7-receptors
#5
Pablo J Sáez, Pablo Vargas, Kenji F Shoji, Paloma A Harcha, Ana-María Lennon-Duménil, Juan C Sáez
Upon its release from injured cells, such as infected, transformed, inflamed, or necrotic cells, extracellular adenosine-5'-triphosphate (ATP) acts as a danger signal that recruits phagocytes, such as neutrophils, macrophages, and dendritic cells (DCs), to the site of injury. The sensing of extracellular ATP occurs through purinergic (P2) receptors. We investigated the cellular mechanisms linking purinergic signaling to DC motility. We found that ATP stimulated fast DC motility through an autocrine signaling loop, which was initiated by the activation of P2X7 receptors and further amplified by pannexin 1 (Panx1) channels...
November 21, 2017: Science Signaling
https://www.readbyqxmd.com/read/29137012/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-diabetic-peripheral-neuropathy-in-type-2-diabetes-mellitus
#6
Tingting Xu, Zihua Weng, Chu Pei, Siyuan Yu, Yating Chen, Wenjie Guo, Xingzuo Wang, Peng Luo, Jia Sun
To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.A total of 557 newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, including 397 T2DM patients without complication (DM group) as well as 160 T2DM patients complicated with DPN (DPN group). Student t test, Mann-Whitney U test, or χ test was applied to the data of the 2 groups, including the levels of neutrophils and lymphocytes as well as the NLR values of peripheral blood and other biochemistry indexes; Pearson correlation analysis was used to calculate the correlation of NLR and detected factors; risk factors of DPN were estimated via logistic regression analysis and multivariate analysis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29124398/patient-perceptions-of-glucocorticoids-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#7
Joanna C Robson, Jill Dawson, Peter F Cronholm, Susan Ashdown, Ebony Easley, Katherine S Kellom, Don Gebhart, Georgia Lanier, Nataliya Milman, Jacqueline Peck, Raashid A Luqmani, Judy A Shea, Gunnar Tomasson, Peter A Merkel
Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) are multisystem diseases of small blood vessels, collectively known as the anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). This study explores the patient's perspective on the use of glucocorticoids, which are still a mainstay of treatment in AAV. Patients with AAV from the UK, USA, and Canada were interviewed, using purposive sampling to include a range of disease manifestations and demographics...
November 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29118872/demographic-endoscopic-and-histopathologic-features-among-stool-h-pylori-positive-and-stool-h-pylori-negative-patients-with-dyspepsia
#8
Mohamed Hassan Emara, Rasha Ibrahim Salama, Amira Amin Salem
Background: Dyspepsia is a common presentation for many patients in gastroenterology clinics. Helicobacter pylori (H. pylori) infection is endemic in many countries around the world and its relation to dyspepsia has long been questioned. This study aimed at comparing demographic, endoscopic and histologic features among dyspeptic patients with and without stool H. pylori antigen positivity. Methods: One hundred and fifty-one consecutive patients with dyspepsia were divided into group I (n = 80) and group II (n = 71) according to positive or negative H...
October 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29070459/-neutrophil-to-lymphocyte-ratio-as-a-predictor-for-type-2-diabetes-mellitus-in-patients-with-chronic-obstructive-pulmonary-disease-a-cohort-study-of-404-cases
#9
Tao Ye, Yin Yang, Kai Wang, Mei Wang, Jia Sun, Yue DU, Xin Chen
OBJECTIVE: To assess the value of neutrophil?to?lymphocyte ratio (NLR) for predicting type 2 diabetes mellitus (T2DM) in patients with chronic obstructive pulmonary disease (COPD). METHODS: A cohort of 404 non?diabetic patients diagnosed with stable COPD between January, 2010 and December, 2012 at Zhujiang Hospital were enrolled and followed up for 3 years, during which fast blood glucose (FBG) was monitored every 6 months. The primary endpoint was the occurrence of T2DM, and the cumulative incidence of T2DM in this cohort was calculated...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29035195/effects-of-fasting-during-the-month-of-ramadan-on-renal-function-in-patients-with-autosomal-dominant-polycystic-kidney-disease%C3%A2
#10
Iskender Ekinci, Reha Erkoc, Meltem Gursu, Elif Ece Dogan, Elif Kilic, Egemen Cebeci, Savas Ozturk, Rumeyza Kazancioglu
BACKGROUND: In this study, we aimed to examine the impact of fasting during the month of Ramadan on autosomal dominant polycystic kidney disease (-ADPKD) patients with normal to near-normal glomerular filtration rate (GFR). MATERIALS AND METHODS: This was a prospective observational study of patients with ADPKD, the majority of whom had normal or near-normal GFR. Patients were divided into two groups: the fasting group (FG) and the nonfasting group (NFG). Assessments in the NFG were performed 1 week before and 1 month after Ramadan, while FG patients were assessed on the last day of fasting in addition to the abovementioned visits...
October 16, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29025077/impact-of-fasting-on-complete-blood-count-assayed-in-capillary-blood-samples
#11
Barbara K Koscielniak, Aleksandra Charchut, Magdalena Wójcik, Krystyna Sztefko, Przemyslaw J Tomasik
Background: To determine the effect of food intake on complete blood count (CBC) results. Method: We analyzed the CBC in whole capillary blood specimens collected from 33 adult volunteers into microtubes between 8:00 AM and 11:00 AM. Blood specimens were drawn from patients who had been fasting 12 hours and then 1 and 2 hours after consumption of a light meal containing carbohydrates, protein, and lipids. All measurements were performed using the hematologic analyzer Sysmex XN-1000...
November 8, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28958144/assessment-of-pn-gal-as-a-marker-of-renal-function-in-elite-cyclists-during-professional-competitions
#12
A Andreazzoli, C Fossati, A Spaccamiglio, R Salvo, F Quaranta, C Minganti, L Di Luigi, P Borrione
Glomerular filtration rate (GFR) has been shown to be lower than physiological values during exercise with a strong negative correlation with exercise intensity. Among new markers of renal function, neutrophil gelatinase-associated lipocalin (NGAL) seems to be very promising. It is an early, sensitive and specific marker of acute kidney injury (AKI) with two isoforms: plasma NGAL (pNGAL) and urinary NGAL (uNGAL). The aim of the present study was to assess acute variations in NGAL plasma levels after performing high endurance physical exercise in a group of professional cyclists during the two major European professional cycling competitions (Giro D’Italia and Tour de France)...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28929912/in%C3%A2-vivo-induction-of-neutrophil-extracellular-traps-by-mycobacterium-tuberculosis-in-a-guinea-pig-model
#13
Georgina Filio-Rodríguez, Iris Estrada-García, Patricia Arce-Paredes, María M Moreno-Altamirano, Sergio Islas-Trujillo, M Dolores Ponce-Regalado, Oscar Rojas-Espinosa
In 2004, a novel mechanism of cellular death, called 'NETosis', was described in neutrophils. This mechanism, different from necrosis and apoptosis, is characterized by the release of chromatin webs admixed with microbicidal granular proteins and peptides (NETs). NETs trap and kill a variety of microorganisms. Diverse microorganisms, including Mycobacterium tuberculosis, are NET inducers in vitro. The aim of this study was to examine whether M. tuberculosis can also induce NETs in vivo and if the NETs are bactericidal to the microorganism...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28910369/heightened-circulating-levels-of-antimicrobial-peptides-in-tuberculosis-diabetes-co-morbidity-and-reversal-upon-treatment
#14
Nathella Pavan Kumar, Kadar Moideen, Vijay Viswanathan, Shanmugam Sivakumar, Pradeep A Menon, Hardy Kornfeld, Subash Babu
BACKGROUND: The association of antimicrobial peptides (AMPs) with tuberculosis-diabetes comorbidity (PTB-DM) is not well understood. METHODS: To study the association of AMPs with PTB-DM, we examined the systemic levels of cathelicidin (LL37), human beta defensin- 2 (HBD2), human neutrophil peptides 1-3, (HNP1-3) and granulysin in individuals with either PTB-DM, PTB, latent TB (LTB) or no TB infection (NTB). RESULTS: Circulating levels of cathelicidin and HBD2 were significantly higher and granulysin levels were significantly lower in PTB-DM compared to PTB, LTB or NTB, while the levels of HNP1-3 were significantly higher in PTB-DM compared to LTB or NTB individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28904022/pi3k%C3%AE-ablation-does-not-promote-diabetes-in-db-db-mice-but-improves-insulin-sensitivity-and-reduces-pancreatic-%C3%AE-cell-apoptosis
#15
Ludovic Breasson, Claudia Sardi, Barbara Becattini, Fabio Zani, Giovanni Solinas
PI3Kγ has emerged as a promising target for the treatment of obesity and insulin resistance; however, previous studies have indicated that PI3Kγ activity in pancreatic β-cells is required for normal insulin secretion in response to glucose. Hence, a possible deterioration of insulin secretion capacity in patients who are predisposed to the failure of pancreatic β-cell function is a major concern for the pharmacologic inhibition of PI3Kγ. To address this issue, we investigated the effects of PI3Kγ ablation in db/db diabetic mice, a genetic model of obesity-driven β-cell failure and diabetes...
September 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28900451/procalcitonin-levels-and-other-biochemical-parameters-in-patients-with-or-without-diabetic-foot-complications
#16
Shatha Abdul Wadood Al-Shammaree, Banan Akram Abu-ALkaseem, Isam N Salman
BACKGROUND: Diagnosis of infection in diabetic foot ulcer (DFU) is not always simple. The analytic precision of procalcitonin (PCT) was evaluated to clarify the use of PCT for distinguish the presence of infection in DFU in comparison to other inflammatory markers. MATERIALS AND METHODS: This study comprised 88 subjects distributed into four groups: 16 nondiabetic healthy subjects (group control), 17 patients with type 2 diabetes mellitus without foot Complication (group DM), 25 patients with noninfected diabetic foot (group NIDF), and 30 patients with infected diabetic foot (group IDF)...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28895791/general-lack-of-correlations-between-age-and-signs-of-the-metabolic-syndrome-in-subjects-with-non-diabetic-fasting-glucose-values
#17
Harry G Preuss, Nate Mrvichin, Dallas Clouatre, Debasis Bagchi, Jeffrey M Preuss, Nicholas V Perricone, Anand Swaroop, Gilbert R Kaats
BACKGROUND: Insulin resistance and advancing age are well-recognized risk factors for metabolic syndrome. Recent reports indicate that fasting glucose levels in non-diabetic patients correlate appropriately with the development of certain elements in metabolic syndrome, which suggest a cause-effect relationship with insulin resistance. OBJECTIVE: The present investigation assessed whether a significant association exists between chronological age and various elements of metabolic syndrome in this same group of subjects possessing non-diabetic fasting glucose levels...
September 12, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28821572/rolling-neutrophils-form-tethers-and-slings-under-physiologic-conditions-in-vivo
#18
Alex Marki, Konrad Buscher, Zbigniew Mikulski, Axel Pries, Klaus Ley
Human and mouse neutrophils are known to form tethers when rolling on selectins in vitro. Tethers are ∼0.2 μm thin, ∼5-10 μm-long structures behind rolling cells that can swing around to form slings that serve as self-adhesive substrates. Here, we developed a mouse intravital imaging method, where the neutrophil surface is labeled by injecting fluorescently labeled mAb to Ly-6G. Venules in the cremaster muscle of live mice were imaged at a high frame rate using a confocal microscope equipped with a fast resonant scanner...
August 18, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28806419/effects-of-short-term-dry-immersion-on-bone-remodeling-markers-insulin-and-adipokines
#19
Marie-Thérèse Linossier, Liubov E Amirova, Mireille Thomas, Myriam Normand, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Marie-Claude Costes-Salon, Christine Bonneau, Claude Gharib, Marc-Antoine Custaud, Laurence Vico
BACKGROUND: Dry immersion (DI), a ground-based model of microgravity previously used in Russia, has been recently implemented in France. The aim of this study was to analyze early events in a short-term DI model in which all conditions are met to investigate who is first challenged from osteo- or adipo-kines and to what extent they are associated to insulin-regulating hormones. METHODS: Twelve healthy men were submitted to a 3-day DI. Fasting blood was collected during pre-immersion phase for the determination of the baseline data collection (BDC), daily during DI (DI24h, DI48H and DI72h), then after recovery (R+3h and R+24h)...
2017: PloS One
https://www.readbyqxmd.com/read/28768458/second-trimester-urinary-neutrophil-gelatinase-associated-lipocalin-levels-in-gestational-diabetes-preliminary-results
#20
Burcu Kisa Karakaya, Gamze Sinem Caglar, Tuba Candar, Hatice Kansu-Celik, Yasemin Tasci, Salim Erkaya
OBJECTIVE: The objective of this study is to investigate the urinary neutrophil gelatinase-associated lipocalin (uNGAL) levels in the second trimester of pregnant patients at the time of gestational diabetes mellitus (GDM) screening. MATERIALS AND METHODS: Urinary samples from 88 pregnant women who underwent gestational diabetes screening test were collected in late second trimester (24-28 weeks) prospectively. After an overnight fasting, 75 g GTT was performed...
August 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
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