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Yvonne Commodore-Mensah, Nadine Matthie, Jessica Wells, Sandra B Dunbar, Cheryl Dennison Himmelfarb, Lisa A Cooper, Rasheeta D Chandler
In the United States (U.S.), Blacks have higher morbidity and mortality from cardiovascular disease (CVD) than other racial groups. The Black racial group includes African Americans (AAs), African immigrants (AIs), and Afro-Caribbeans (ACs); however, little research examines how social determinants differentially influence CVD risk factors in each ethnic subgroup. We analyzed the 2010-2014 National Health Interview Survey, a cross-sectional, nationally representative survey of non-institutionalized civilians...
December 12, 2017: Journal of Racial and Ethnic Health Disparities
Erik R Svendsen, Melissa Gonzales, Adwoa Commodore
The El Paso Children's Health Study examined environmental risk factors for allergy and asthma among fourth and fifth grade schoolchildren living in a major United States-Mexico border city. Complete questionnaire information was available for 5210 children, while adequate pulmonary function data were available for a subset of 1874. Herein we studied indoor environmental health risk factors for allergy and asthma. Several indoor environmental risk factors were associated with allergy and asthma. In particular, we found that ant and spider pest problems, pet dogs, fireplace heat, central air conditioning, humidifier use, and cooking with gas stoves were positively associated with both allergy and asthma prevalence...
March 2018: Science of the Total Environment
Charles Agyemang, Gertrude Nyaaba, Erik Beune, Karlijn Meeks, Ellis Owusu-Dabo, Juliet Addo, Ama de-Graft Aikins, Frank P Mockenhaupt, Silver Bahendeka, Ina Danquah, Matthias B Schulze, Cecilia Galbete, Joachim Spranger, Peter Agyei-Baffour, Peter Henneman, Kerstin Klipstein-Grobusch, Adebowale Adeyemo, Jan van Straalen, Yvonne Commodore-Mensah, Lambert T Appiah, Liam Smeeth, Karien Stronks
OBJECTIVES: Hypertension is a major burden among African migrants, but the extent of the differences in prevalence, treatment, and control among similar African migrants and nonmigrants living in different contexts in high-income countries and rural and urban Africa has not yet been assessed. We assessed differences in hypertension prevalence and its management among relatively homogenous African migrants (Ghanaians) living in three European cities (Amsterdam, London, and Berlin) and nonmigrants living in rural and urban Ghana...
January 2018: Journal of Hypertension
Yvonne Commodore-Mensah, Nwakaego Ukonu, Lisa A Cooper, Charles Agyemang, Cheryl Dennison Himmelfarb
The burden of cardiovascular disease (CVD) risk in ethnic minorities in the United States (US) is high. Acculturation may worsen or improve cardiovascular health in immigrants. We sought to examine the association between acculturation and elevated cardiovascular disease risk in African immigrants, a growing immigrant population in the US. We conducted a cross-sectional study of Ghanaian and Nigerian born-African immigrants in the US. To determine whether acculturation was associated with having elevated CVD risk (defined as ≥3 CVD risk factors or Pooled Cohort Equations score ≥7...
August 29, 2017: Journal of Immigrant and Minority Health
Adwoa Commodore, Sacoby Wilson, Omar Muhammad, Erik Svendsen, John Pearce
Neighborhood level air pollution represents a long-standing issue for many communities that, until recently, has been difficult to address due to the cost of equipment and lack of related expertise. Changes in available technology and subsequent increases in community-based participatory research (CBPR) have drastically improved the ability to address this issue. However, much still needs to be learned as these types of studies are expected to increase in the future. To assist, we review the literature in an effort to improve understanding of the motivations, approaches, and outcomes of air monitoring studies that incorporate CBPR and citizen science (CS) principles...
August 2017: Environmental Monitoring and Assessment
Juliette J Commodore, Xinyao Jing, Carolyn J Cassady
RATIONALE: Production of multiply protonated ions by electrospray ionization (ESI) is important to the analysis of peptides by mass spectrometry. For small neutral and acidic peptides, addition of chromium(III) greatly increases the intensity of doubly protonated ions. The current study examines instrumental and solution parameters that maximize peptide ion charge by ESI. METHODS: The neutral and basic heptapeptides AAAAAAA (A7) and AAAKAAA (A3KA3) were used as test compounds and electrosprayed from a solution containing chromium(III) nitrate at a peptide to metal molar ratio of 1:10...
July 15, 2017: Rapid Communications in Mass Spectrometry: RCM
Juliette J Commodore, Carolyn J Cassady
Using the lanthanide ion praseodymium, Pr(III), metallated ion formation and electron transfer dissociation (ETD) were studied for 25 biological and model acidic peptides. For chain lengths of seven or more residues, even highly acidic peptides that can be difficult to protonate by electrospray ionization will metallate and undergo abundant ETD fragmentation. Peptides composed of predominantly acidic residues form only the deprotonated ion, [M + Pr - H](2+) ; this ion yields near complete ETD sequence coverage for larger peptides...
April 2017: Journal of Mass Spectrometry: JMS
Yvonne Commodore-Mensah, Nwakaego Ukonu, Olawunmi Obisesan, Jonathan Kumi Aboagye, Charles Agyemang, Carolyn M Reilly, Sandra B Dunbar, Ike S Okosun
BACKGROUND: Cardiometabolic risk (CMR) factors including hypertension, overweight/obesity, diabetes mellitus, and hyperlipidemia are high among United States ethnic minorities, and the immigrant population continues to burgeon. METHODS AND RESULTS: Hypothesizing that acculturation (length of residence) would be associated with a higher prevalence of CMR factors, the authors analyzed data on 54, 984 US immigrants in the 2010-2014 National Health Interview Surveys...
November 4, 2016: Journal of the American Heart Association
Zheng Li, Adwoa Commodore, Stella Hartinger, Michael Lewin, Andreas Sjödin, Erin Pittman, Debra Trinidad, Kendra Hubbard, Claudio F Lanata, Ana I Gil, Daniel Mäusezahl, Luke P Naeher
BACKGROUND: Household air pollution (HAP) from indoor biomass stoves contains harmful pollutants, such as polycyclic aromatic hydrocarbons (PAHs), and is a leading risk factor for global disease burden. We used biomonitoring to assess HAP exposure and association with self-reported symptoms in 334 non-smoking Peruvian women to evaluate the efficacy of a stove intervention program. METHODS: We conducted a cross-sectional study within the framework of a community randomized control trial...
December 2016: Environment International
Cheryl R Dennison Himmelfarb, Yvonne Commodore-Mensah, Martha N Hill
The role of the nurse in improving hypertension control has expanded over the past 50 years, complementing and supplementing that of the physician. Nurses' involvement began with measuring and monitoring blood pressure (BP) and patient education and has expanded to become one of the most effective strategies to improve BP control. Today the roles of nurses and nurse practitioners (NPs) in hypertension management involve all aspects of care, including (1) detection, referral, and follow up; (2) diagnostics and medication management; (3) patient education, counseling, and skill building; (4) coordination of care; (5) clinic or office management; (6) population health management; and (7) performance measurement and quality improvement...
March 2016: Annals of Global Health
Juliette J Commodore, Carolyn J Cassady
Electrospray ionization (ESI) on mixtures of acidic fibrinopeptide B and two peptide analogs with trivalent lanthanide salts generates [M + Met + H](4+), [M + Met](3+), and [M + Met -H](2+), where M = peptide and Met = metal (except radioactive promethium). These ions undergo extensive and highly efficient electron transfer dissociation (ETD) to form metallated and non-metallated c- and z-ions. All metal adducted product ions contain at least two acidic sites, which suggest attachment of the lanthanide cation at the side chains of one or more acidic residues...
September 2016: Journal of the American Society for Mass Spectrometry
Olawunmi Obisesan, Wen-Hung Kuo, Michael Brunet, Adekunle Obisesan, Olubusayo Akinola, Yvonne Commodore-Mensah
Obesity is a highly prevalent cardiovascular disease risk factor globally and in African-descent populations. A cross-sectional study of obesity among a Nigerian immigrant sample population in the United States was conducted. Data was obtained through a web-based survey. Spearman's correlation and logistic regression were used to determine sociodemographic and behavioral determinants of obesity. The results showed no significant relationship between obesity and education, socioeconomic status, length of stay, and level of physical activity...
April 2017: Journal of Immigrant and Minority Health
Hirohumi Arakawa, Machender R Kandadi, Evgeniy Panzhinskiy, Kenneth Belmore, Ge Deng, Ebony Love, Preshus M Robertson, Juliette J Commodore, Carolyn J Cassady, Sreejayan Nair, John B Vincent
While trivalent chromium has been shown at high doses to have pharmacological effects improving insulin resistance in rodent models of insulin resistance, the mechanism of action of chromium at a molecular level is not known. The chromium-binding and transport agent low-molecular-weight chromium-binding substance (LMWCr) has been proposed to be the biologically active form of chromium. LMWCr has recently been shown to be comprised of a heptapeptide of the sequence EEEEDGG. The binding of Cr(3+) to this heptapeptide has been examined...
June 2016: Journal of Biological Inorganic Chemistry: JBIC
Andrew Meillier, Marius Commodore
Sarcoidosis is a chronic systemic disease with a wide array of clinical findings. Given that the clinical symptoms are not pathognomonic, chest radiographs have become essential to the initial diagnosis and choice of treatment modality. Diagnosis hinges on ruling out alternative diagnoses; sometimes, advanced radiologic techniques and histopathology are required. On this occasion, we present a case of a patient with generalized symptoms, no significant chest radiograph findings and lymphadenopathy where advanced imaging and pathology assisted in the diagnosis...
December 2015: Oxford Medical Case Reports
Yvonne Commodore-Mensah, Cheryl Dennison Himmelfarb, Charles Agyemang, Anne E Sumner
In the 20th century, Africans in Sub-Saharan Africa had lower rates of cardiometabolic disease than Africans who migrated. However, in the 21st century, beyond infectious diseases, the triple epidemics of obesity, diabetes and hypertension have taken hold in Africa. Therefore, Africans are acquiring these chronic diseases at different rates and different intensity prior to migration. To ensure optimal care and health outcomes, the United States practice of grouping all African-descent populations into the "Black/African American" category without regard to country of origin masks socioeconomic and cultural differences and needs re-evaluation...
2015: Ethnicity & Disease
Anna R Batt, Commodore P St Germain, Trevor Gokey, Anton B Guliaev, Teaster Baird
The development of effective protease therapeutics requires that the proteases be more resistant to naturally occurring inhibitors while maintaining catalytic activity. A key step in developing inhibitor resistance is the identification of key residues in protease-inhibitor interaction. Given that majority of the protease therapeutics currently in use are trypsin-fold, trypsin itself serves as an ideal model for studying protease-inhibitor interaction. To test the importance of several trypsin-inhibitor interactions on the prime-side binding interface, we created four trypsin single variants Y39A, Y39F, K60A, and K60V and report biochemical sensitivity against bovine pancreatic trypsin inhibitor (BPTI) and M84R ecotin...
September 2015: Protein Science: a Publication of the Protein Society
Changgeng Feng, Juliette J Commodore, Carolyn J Cassady
The addition of chromium(III) nitrate to solutions of peptides with seven or more residues greatly increases the formation of doubly protonated peptides, [M + 2H](2+), by electrospray ionization. The test compound heptaalanine has only one highly basic site (the N-terminal amino group) and undergoes almost exclusive single protonation using standard solvents. When Cr(III) is added to the solution, abundant [M + 2H](2+) forms, which involves protonation of the peptide backbone or the C-terminus. Salts of Al(III), Mn(II), Fe(III), Fe(II), Cu(II), Zn (II), Rh(III), La(III), Ce(IV), and Eu(III) were also studied...
February 2015: Journal of the American Society for Mass Spectrometry
Casey R Shillam, Grace Ho, Yvonne Commodore-Mensah
Rapid changes in health care delivery require nurses to attain advanced knowledge, skills, and attitudes in biostatistics to provide high-quality, safe patient care. Advances in educational technologies support the delivery of graduate nursing education in online formats. Given the diversity of learning styles among graduate nursing students and the specific challenges in delivering biostatistics content in traditional formats, it is vital to include different delivery formats to engage and meet the learning needs of graduate nursing students who take biostatistics courses online...
April 2014: Journal of Nursing Education
Cheryl R Dennison Himmelfarb, Yvonne Commodore-Mensah, Laura L Hayman
No abstract text is available yet for this article.
March 2014: Journal of Cardiovascular Nursing
Yvonne Commodore-Mensah, Laura J Samuel, Cheryl R Dennison-Himmelfarb, Charles Agyemang
CONTEXT: There is a growing prevalence of cardiovascular disease (CVD) risk factors in West Africa and among its migrants to industrialized countries. Despite this, no study has reviewed CVD risk factor prevalence among West Africans in Africa and industrialized countries. OBJECTIVE: To appraise studies on the prevalence of two CVD risk factors (hypertension and overweight/obesity) among two major West African populations (Ghanaians and Nigerians) in Africa and industrialized countries...
March 2014: Journal of Hypertension
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