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Esophageal cancer

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https://www.readbyqxmd.com/read/29469012/nutritional-status-and-postoperative-outcomes-in-patients-with-gastrointestinal-cancer-in-vietnam-a-retrospective-cohort-study
#1
Bui Thi Hong Loan, Shinji Nakahara, Bui An Tho, Tran Ngoc Dang, Le Ngoc Anh, Nguyen Do Huy, Masao Ichikawa
BACKGROUND: Nutritional support for surgical care is crucial because hospital malnutrition is rather common. However, low- and middle-income countries have not adequately addressed nutritional management of surgical patients. To highlight need for nutritional management in surgical patients, the present study aimed to describe preoperative nutritional status in patients who underwent gastrointestinal cancer surgery in Vietnam and to investigate the relationship between preoperative malnutrition and adverse outcomes, such as postoperative complications and prolonged length of hospital stay...
December 6, 2017: Nutrition
https://www.readbyqxmd.com/read/29468376/gastric-per-oral-endoscopic-myotomy-g-poem-for-the-treatment-of-refractory-gastroparesis-early-experience
#2
Zubair Malik, Rahul Kataria, Rani Modayil, Adam C Ehrlich, Ron Schey, Henry P Parkman, Stavros N Stavropoulos
BACKGROUND: Gastric per oral endoscopic myotomy (G-POEM) of the pylorus is a technique that is recently being used to treat gastroparesis. Our aim was to report our experience in performing G-POEM for refractory gastroparesis of different etiologies and determine symptom improvement. METHODS: Thirteen patients undergoing G-POEM are reported. Pre- and post-procedure gastric emptying study (GES) and PAGI-SYM for symptom severity were obtained. Patients underwent G-POEM by creating a submucosal tunnel starting in the greater curvature of the distal antrum and extending it to the beginning of the duodenal bulb, followed by a full thickness pyloromyotomy...
February 22, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29467895/clinicopathological-and-functional-implications-of-the-inhibitor-of-apoptosis-proteins-survivin-and-xiap-in-esophageal-cancer
#3
Levent Dizdar, Lisa M Jünemann, Thomas A Werner, Pablo E Verde, Stephan E Baldus, Nikolas H Stoecklein, Wolfram T Knoefel, Andreas Krieg
Based on their overexpression and important roles in progression and therapy-resistance in malignant diseases, the inhibitor of apoptosis protein family (IAP) members, survivin and X-linked inhibitor of apoptosis protein (XIAP), represent attractive candidates for targeted therapy. The present study investigated the prognostic and biological relevance of survivin and XIAP in esophageal squamous-cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). Survivin and XIAP expression was analyzed by immunohistochemistry using tissue microarrays containing 120 ESCC and 90 EAC samples as well as the corresponding non-neoplastic esophageal mucosa samples...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467876/comparison-of-the-safety-of-the-application-of-painless-gastroscopy-and-ordinary-gastroscopy-in-chronic-hypertension-patients-combined-with-early-gastric-cancer
#4
Fangli Men, Lianmin Wei, Bing Liu, Fengting Wu, Jingyu Liu, Ni Guo, Qing Niu
The aim of the present study was to compare the safety of the application of painless gastroscopy and ordinary gastroscopy for chronic hypertension patients combined with early gastric cancer. A total of 123 patients with early gastric cancer were selected at the Dongying People's Hospital from June, 2014 to August, 2016. The patients were randomly divided into the painless (n=63) and ordinary (n=60) gastroscopy groups. Proper pretreatment was performed according to whether anesthesia was performed or not. Arterial pressure, heart rate, and blood oxygen saturation were detected and compared before anesthesia, when gastroscope passed through the esophageal entrance plane, and after recovery from anesthesia...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467557/esophageal-metastasis-of-stem-cell-subtype-hepatocholangiocarcinoma-rare-presentation-of-a-rare-tumor
#5
Maëva Salimon, Nicolas Chapelle, Tamara Matysiak-Budnik, Jean-François Mosnier, Eric Frampas, Yann Touchefeu
Hepatocholangiocarcinoma (cHCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable cHCC-ICC with stem-cell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29467556/predictors-of-post-treatment-stenosis-in-cervical-esophageal-cancer-undergoing-high-dose-radiotherapy
#6
Jun Won Kim, Tae Hyung Kim, Jie-Hyun Kim, Ik Jae Lee
AIM: To evaluate toxicity and treatment outcome of high-dose radiotherapy (RT) for cervical esophageal cancer (CEC). METHODS: We reviewed a total of 62 consecutive patients who received definitive RT for stage I to III cervical esophageal cancer between 2001 and 2015. Patients who received < 45 Gy, treated for lesions below sternal notch, treated with palliative aim, treated with subsequent surgical resection, or diagnosed with synchronous hypopharyngeal cancer were excluded...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29465538/enhanced-recovery-after-surgery-eras-programs-for-esophagectomy-protocol-for-a-systematic-review-and-meta-analysis
#7
Feiyu Liu, Wei Wang, Chengde Wang, Xiaonu Peng
BACKGROUND: Esophageal cancer is one of the worst malignant digestive neoplasms with poor treatment outcomes. Esophagectomy plays an important role and offers a potential curable chance to these patients. However, esophagectomy with radical lymphadenectomy is known as one of the most invasive digestive surgeries which are associated with high morbidity and mortality. The enhanced recovery after surgery (ERAS) protocol is a patient-centered, surgeon-led system combining anesthesia, nursing, nutrition, and psychology, which is designed for reducing complications, promoting recovery, and improving treatment outcomes...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29463194/the-expression-and-prognostic-impact-of-the-pi3k-akt-mtor-signaling-pathway-in-advanced-esophageal-squamous-cell-carcinoma
#8
Ning Wu, Zunguo Du, Yongjun Zhu, Yang Song, Liewen Pang, Zhiming Chen
The abnormal phosphatase and tensin homolog expression and activated phosphoinositide-3 kinase/Protein kinase B (AKT)/mammalian target of rapamycin signaling pathway are involved in the progression of esophageal squamous cell carcinoma. By assessing the expression pattern of key components in the phosphoinositide-3 kinase/AKT/mammalian target of rapamycin signaling pathway by immunohistochemistry in tumor and nontumor esophageal mucosa from patients with esophageal squamous cell carcinomas, we aimed to carefully explore the relationship between the various protein expressions and clinicopathological factors, as well as patient outcome...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29463006/long-term-oncologic-outcomes-opioid-use-and-complications-after-esophageal-cancer-surgery
#9
Tak Kyu Oh, Kwhanmien Kim, Sang Hoon Jheon, Sang-Hwan Do, Jung-Won Hwang, Young-Tae Jeon, Kooknam Kim, In-Ae Song
Effective and adequate opioid use and prevention of postoperative complications are important for enhanced recovery after surgery. We examined the effects of postoperative opioid use and postoperative complications on overall survival and recurrence-free survival after esophageal cancer surgery. This retrospective cohort study analyzed the records of patients diagnosed with esophageal cancer who underwent the Ivor Lewis operation between January 2005 and December 2011. We collected data on total opioid use for 8 days postoperatively, as well as information on postoperative complications (Clavien-Dindo classification)...
February 19, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29462754/a-case-of-separation-surgery-with-drainage-tube-less-dress-esophagostomy-for-advanced-cancer-with-a-respiratory-fistula
#10
Yukinori Tanoue, Shinsuke Takeno, Fumiaki Kawano, Kousei Tashiro, Rouko Hamada, Yasuyuki Miyazaki, Atsushi Nanashima
INTRODUCTION: An esophagorespiratory fistula (ERF) can cause severe pneumonia or a lung abscess which progresses to life-threatening sepsis. A case of a patient with esophageal cancer and an esophagopulmonary fistula (EPF) who underwent separation surgery with drainage tube-less (DRESS) esophagostomy and was promptly started on definitive chemoradiotherapy (CRT) is reported. PRESENTATION OF CASE: A 79-year-old man visited a clinic with a month-long history of dysphagia...
February 13, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29461644/rasgrp3-a-ras-guanyl-releasing-protein-3-that-contributes-to-malignant-proliferation-and-aggressiveness-in-human-esophageal-squamous-cell-carcinoma
#11
Ziteng Zhang, Ming Ma, Ronghang Hu, Baobin Xu, Ling Zong, Haixiang Wei, Yanhong Meng
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide; however, clinical and pathological parameters have limited ability in discriminating between clinically significant and indolent ESCC. Since RasGRP3 transcript levels have prognostic value in discriminating ESCC with different clinical aggressiveness, we decided to investigate its putative oncogenic role in ESCC. We found that RasGRP3 was highly expressed in ESCC cells. Suppression of endogenous RasGRP3 expression in esophageal cell lines reduced Ras-GTP formation as well as AKT phosphorylation...
February 20, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29459808/-submucosal-endoscopic-dissection-in-the-treatment-of-early-esophageal-cancer
#12
Liliana Ughelli, Carolina Miranda, Carlos Galeano, María Del Carmen Blasco, Guliano Boselli, Antonio Cubilla, Paulo Sakai, Carmelo Blasco
We report the case of a male patient, 80 years old, with a history of dyspepsia and no family history of neoplasias. In the upper digestive endoscopy in the distal esophagus, a flat depressed lesion with the appearance of early carcinoma, type IIC of Paris classification, was diagnosed by biopsy as a squamous carcinoma in situ, infiltrating, moderately differentiated non-keratinizing grade II carcinoma. He underwent submucosal endoscopic dissection without complications. Histopathology concluded: carcinoma of squamous cells, predominantly in situ of distal esophagus, measuring 0...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29459017/poor-performance-in-incremental-shuttle-walk-and-cardiopulmonary-exercise-testing-predicts-poor-overall-survival-for-patients-undergoing-esophago-gastric-resection
#13
Jessica Whibley, Christopher J Peters, Laura J Halliday, Asif M Chaudry, William H Allum
INTRODUCTION: Esophageal and gastric cancer have a poor prognosis and surgical intervention is associated with considerable morbidity, highlighting the need for careful preoperative assessment. The Incremental Shuttle Walk Test (ISWT) and Cardiopulmonary exercise testing (CPET) can assess preoperative fitness. This study aims to investigate their correlation with both postoperative respiratory complications and overall survival. PATIENTS AND METHODS: Patients were identified who underwent esophageal or gastric resections for cancer between 2010 and 2014 and had ISWT and/or CPET assessments...
February 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29458005/14-3-3%C3%AE-promotes-esophageal-squamous-cell-carcinoma-invasion-by-repressing-s1pr2-protein-expression-through-nf-%C3%AE%C2%BAb-signaling
#14
Tong Song, Chen Sheng-Cai, Xu Kai-Ying, Fang Bin, Wang Si-Hua, Wang Jian-Jun
14-3-3ζ is overexpressed in several cancers, including esophageal squamous cell carcinoma (ESCC), and plays an important role in tumorigenesis. However, the mechanisms underlying its tumorigenesis remain unclear. Here we report that 14-3-3ζ was upregulated in ESCC tumors, compared with adjacent normal tissues; 14-3-3ζ levels were positively correlated with ESCC lymph node metastasis and recurrence. Overexpression of 14-3-3ζ promoted the tumor growth and invasion of ESCC in vitro and in vivo, whereas depletion of 14-3-3ζ suppressed these effects...
February 16, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29456850/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-the-prediction-of-survival-in-patients-with-advanced-esophageal-cancer-who-have-undergone-neoadjuvant-chemotherapy
#15
Masahiko Yano, Hiroshi Miyata, Keijiro Sugimura, Masaaki Motoori, Takeshi Omori, Yoshiyuki Fujiwara, Norikatsu Miyoshi, Masayoshi Yasui, Masayuki Ohue, Hirofumi Akita, Akira Tomokuni, Hidenori Takahashi, Shogo Kobayashi, Masato Sakon
Neoadjuvant chemotherapy (NAC) is a promising treatment strategy for advanced esophageal cancer. However, measures of NAC response assessment and prognostic prediction have not yet been established. The aim of this study was to evaluate the usefulness of combined18 F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT). A total of 77 patients with stage IB-IV esophageal cancer who were treated with NAC followed by curative resection were retrospectively analyzed. PET/CT was performed before and after NAC and 56 patients were clinical responders...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456742/mir302a-inhibits-the-proliferation-of-esophageal-cancer-cells-through-the-mapk-and-pi3k-akt-signaling-pathways
#16
Daokui Xia, Shumei Tian, Zhen Chen, Wenchao Qin, Quan Liu
MicroRNAs (miRNAs/miRs) are involved in the regulation of various types of cancer, either as oncogenes or tumor suppressors. miR302a has been reported that it could suppress tumor cell proliferation by inhibiting Akt in prostate cancer. The present study examined the effect of miR302a on proliferation and invasion in esophageal cancer cell lines. The expression levels of miR302a in esophageal cancer cell lines was determined by reverse transcription-polymerase chain reaction. Subsequently, miR302a mimics were transfected into esophageal cancer cells, and cell viability and invasion were assessed by MTT and Transwell assays...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456736/-brucea-javanica-seed-oil-enhances-the-radiosensitivity-of-esophageal-cancer-by-inhibiting-hypoxia-inducible-factor-1%C3%AE-in-vitro-and-in-vivo
#17
Peng Pan, Bai-Xia Yang, Xiao-Lin Ge
Brucea javanica oil emulsion (BJOE) has been used clinically to treat esophageal cancer combined with radiotherapy for numerous years in China. However, the detailed mechanism remains unclear. Thus, the effects of BJOE on the radiosensitivity of esophageal squamous cell carcinoma (ESCC) were evaluated in vitro and in vivo . The growth inhibitory effects of different BJOE concentrations were determined through an MTT assay. Radiosensitivity was evaluated through focal formation measurements and clone formation assays...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29455958/esophagectomy-versus-endoscopic-resection-for-patients-with-early-stage-esophageal-adenocarcinoma-a-national-cancer-database-propensity-matched-study
#18
Katy A Marino, Jennifer L Sullivan, Benny Weksler
OBJECTIVES: Endoscopic resection has been rapidly adopted in the treatment of early-stage esophageal tumors. We compared the outcomes after esophagectomy or endoscopic resection for stage T1a adenocarcinoma. METHODS: We queried the National Cancer Database for patients with T1a esophageal adenocarcinoma who underwent esophagectomy or endoscopic resection and generated a balanced cohort with 735 matched pairs using propensity-score matching. We then performed a multivariable Cox regression analysis on the matched and unmatched cohorts...
January 31, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29455652/expression-regulation-and-targeting-of-receptor-tyrosine-kinases-in-esophageal-squamous-cell-carcinoma
#19
REVIEW
Manoj Kumar Kashyap, Omar Abdel-Rahman
Esophageal cancer is one of the most common types of cancer, which is a leading cause of cancer-related death worldwide. Based on histological behavior, it is mainly of two types (i) Esophageal squamous cell carcinoma (ESCC), and (ii) esophageal adenocarcinoma (EAD or EAC). In astronomically immense majority of malignancies, receptor tyrosine kinases (RTKs) have been kenned to play a consequential role in cellular proliferation, migration, and metastasis of the cells. The post-translational modifications (PTMs) including phosphorylation of tyrosine (pY) residue of the tyrosine kinase (TK) domain have been exploited for treatment in different malignancies...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29455424/hypo-fractionated-stereotactic-radiation-therapy-for-lung-malignancies-by-means-of-helical-tomotherapy-report-of-feasibility-by-a-single-center-experience
#20
Vanessa Figlia, Rosario Mazzola, Francesco Cuccia, Filippo Alongi, Gianluca Mortellaro, Daniela Cespuglio, Teresa Cucchiara, Giuseppina Iacoviello, Vito Valenti, Massimo Molino, Francesco Verderame, Domenica Matranga, Antonio Lo Casto, Giuseppe Ferrera
BACKGROUND: Several experiences in the literature report SBRT as an effective treatment option for medically inoperable early stage non-small cell lung cancer (NSCLC) and oligometastatic disease. The optimal fractionation schedules and total dose remain controversial. In this study, we evaluated the safety in terms of toxicity and efficacy of using of 8-10 fractions schedules with Helical Tomotherapy (HT) for primary and metastatic lung lesions. METHODS: Between March 2014 and May 2016, a total of 39 patients (median age 72 years, range 26-91) were treated with HT-SBRT for malignant lung lesions: 22 patients with early stage NSCLC, 17 with oligometastases...
February 17, 2018: La Radiologia Medica
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