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https://www.readbyqxmd.com/read/29052817/androgen-signaling-in-esophageal-adenocarcinoma-cell-lines-in-vitro
#1
Helen M Palethorpe, Paul A Drew, Eric Smith
BACKGROUND: We showed previously that nuclear localization of the androgen receptor (AR) and expression of the androgen-responsive gene FK506-binding protein 5 (FKBP5) in esophageal adenocarcinoma (EAC) tissues were associated with decreased patient survival, suggesting a role for androgens in this cancer. AIM: To investigate the effect of the AR ligand 5α-dihydrotestosterone (DHT) on AR-expressing EAC cell lines in vitro. METHODS AND RESULTS: In tissue resection specimens from EAC patients, FKBP5 expression was positively associated with proliferation as measured by Ki-67 expression...
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29052783/anatomical-study-of-the-left-superior-mediastinal-lymphatics-for-tracheal-branches-of-left-recurrent-laryngeal-nerve-preserving-mediastinoscope-assisted-surgery-in-esophageal-cancer
#2
Yutaka Nakajima, Yutaka Tokairin, Yasuaki Nakajima, Kenro Kawada, Kagami Nagai, Kumiko Yamaguchi, Keiichi Akita, Tatsuyuki Kawano
PURPOSE: Curative treatment of esophageal cancer requires meticulous superior mediastinal lymphadenectomy, in addition to esophagectomy, because superior mediastinal lymph node metastases are common in esophageal cancer. When preserving the tracheal branches of the left recurrent laryngeal nerve (RLN), good anatomical understanding is required for confirmation of the positional relationships between the courses of lymphatic vessels, lymph node distribution, and the left RLN and its tracheal branches...
October 20, 2017: Surgery Today
https://www.readbyqxmd.com/read/29052514/five-fraction-sbrt-for-ultra-central-nsclc-in-field-recurrences-following-high-dose-conventional-radiation
#3
Michael C Repka, Nima Aghdam, Shaan K Kataria, Lloyd Campbell, Simeng Suy, Sean P Collins, Eric Anderson, Jonathan W Lischalk, Brian T Collins
PURPOSE/OBJECTIVE: Local treatment options for patients with in-field non-small cell lung cancer (NSCLC) recurrence following conventionally fractionated external beam radiation therapy (CF-EBRT) are limited. Stereotactic body radiation therapy (SBRT) is a promising modality to achieve reasonable local control, although toxicity remains a concern. MATERIALS/METHODS: Patients previously treated with high-dose CF-EBRT (≥59.4 Gy, ≤3 Gy/fraction) for non-metastatic NSCLC who underwent salvage SBRT for localized ultra-central in-field recurrence were included in this analysis...
October 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29051991/radiation-induced-liver-injury-mimicking-liver-metastases-on-fdg-pet-ct-after-chemoradiotherapy-for-esophageal-cancer-a%C3%A2-retrospective-study-and-literature-review
#4
Francine E M Voncken, Berthe M P Aleman, Jolanda M van Dieren, Cecile Grootscholten, Ferry Lalezari, Johanna W van Sandick, Jeffrey D Steinberg, Erik Vegt
BACKGROUND: For esophageal cancer patients treated with neoadjuvant chemoradiotherapy (nCRT), restaging using F‑18-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET-CT) following nCRT can detect interval metastases, including liver metastases, in almost 10% of patients. However, in clinical practice, focal FDG liver uptake, unrelated to liver metastases, is observed after chemoradiotherapy. This radiation-induced liver injury (RILI) can potentially lead to overstaging...
October 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29051037/serum-microrna-signature-predicts-response-to-high-dose-radiation-therapy-in-locally-advanced-non-small-cell-lung-cancer
#5
Yilun Sun, Peter G Hawkins, Nan Bi, Robert T Dess, Muneesh Tewari, Jason W D Hearn, James A Hayman, Gregory P Kalemkerian, Theodore S Lawrence, Randall K Ten Haken, Martha M Matuszak, Feng-Ming Kong, Shruti Jolly, Matthew J Schipper
PURPOSE: To assess the utility of circulating serum microRNAs (c-miRNAs) to predict response to high-dose radiation therapy for locally advanced non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Data from 80 patients treated from 2004 to 2013 with definitive standard- or high-dose radiation therapy for stages II-III NSCLC as part of 4 prospective institutional clinical trials were evaluated. Pretreatment serum levels of 62 miRNAs were measured by quantitative reverse transcription-polymerase chain reaction array...
September 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29050933/foxk1-plays-an-oncogenic-role-in-the-development-of-esophageal-cancer
#6
Di Chen, Kai Wang, Xiaowei Li, Mingzuo Jiang, Lu Ni, Bing Xu, Yi Chu, Weijie Wang, Hua Wang, Huijie Kang, Kaichun Wu, Jie Liang, Gui Ren
Forkhead box k1 (FOXK1) is a member of the FOX class of transcription factors and it is dysregulated in many solid tumors including hepatocellular carcinoma, gastric cancer, colorectal cancer and prostate cancer. However, the expression status of FOXK1 and its clinical significance in esophageal cancer (EC) is still uncertain. Our study aimed at investigating the significance of FOXK1 expression in human EC and its biological function in the development of EC. We found that FOXK1 was overexpressed in EC tissues compared with corresponding non-tumor tissues using immunohistochemistry...
October 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29050260/epigenetic-silencing-of-tmem176a-promotes-esophageal-squamous-cell-cancer-development
#7
Ying Wang, You Zhang, James G Herman, Enqiang Linghu, Mingzhou Guo
The function of human transmembrane protein 176A (TMEM176A) in cancer remains unclear. To understand the function and mechanism of TMEM176A in human esophageal cancer development, 13 esophageal cancer cell lines and 267 cases of primary esophageal squamous cell cancer (ESCC) samples were analyzed by methylation specific PCR (MSP), flow cytometry, immunohistochemistry and transfection assays. TMEM176A was highly expressed in BIC1 cells and loss of TMEM176A expression was found in TE1, TE3, TE13, KYSE140, KYSE180, KYSE410, KYSE450, KYSE520, Segl, KYSE150, YES2 and COLO680N cells...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050228/mutation-landscape-and-intra-tumor-heterogeneity-of-two-manecs-of-the-esophagus-revealed-by-multi-region-sequencing
#8
Wenqing Yuan, Zhen Liu, Wanjun Lei, Li Sun, Haijun Yang, Yu Wang, Shweta Ramdas, Xiao Dong, Ruiping Xu, Hong Cai, Jun Z Li, Yang Ke
Mixed adenoneuroendocrine carcinoma (MANEC) in the esophagus is an infrequent but highly malignant cancer with few known genomic alterations. We conducted whole-exome sequencing and whole-genome SNP genotyping for 4-6 tumor subregions and 5-6 adjacent normal tissue sites and 1-3 lymph node metastases in two esophageal MANECs to detect somatic mutations and copy number alterations, and to explore their spatial heterogeneity and underlying clonal structure. TP53 mutation, RB1 deletion or LOH, and PIK3CA, PTEN, KRAS, SOX2, DVL3, TP63 amplification appeared in all regions in both tumors...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050127/-immune-related-pneumonitis-caused-by-programmed-death-1-inhibitor-pembrolizumab-a-case-report-and-literature-review
#9
Y L Chen, J Zhao, R Jia, H Y Wang, J Zheng, C Q Bai, M Z Wang, J M Xu
Objective: To investigate the risk factors, clinical manifestations, radiological features, diagnosis, treatment and prognosis of immune-related pneumonitis caused by programmed death-1(PD-1)/PD-L1 inhibitors. Methods: The clinical data of immune-related pneumonitis caused by PD-1 inhibitor Pembrolizumab in a patient with advanced esophageal carcinoma admitted to the 307(th) Hospital of Chinese People's Liberation Army was retrospectively analyzed and the related literatures were reviewed. We searched Medline database using the keywords"PD-1 inhibitor","PD-L1 inhibitor","Pembrolizumab","Nivolumab","Atezolizumab"combined with"Pneumonitis"by Mar 31, 2017...
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29049013/identification-and-validation-of-fibroblast-growth-factor-12-gene-as-a-novel-potential-biomarker-in-esophageal-cancer-using-cancer-genomic-datasets
#10
Ashish Bhushan, Avninder Singh, Sujala Kapur, Bibhuti B Borthakar, Jagannath Sharma, Avdhesh K Rai, Amal C Kataki, Sunita Saxena
Esophageal squamous cell carcinoma (ESCC) has a complex, multifactorial etiology in which environmental, geographical, and genetic factors play major roles. It is the second most common cancer among men and the fourth most common among women in India, with a particularly high prevalence in Northeast India. In this study, an integrative in silico [DAVID, NCG5.0, Oncomine, Cancer Cell Line Encyclopedia, and The Cancer Genome Atlas (TCGA)] approach was used to identify the potential biomarkers by using the available three genomic datasets on ESCC from Northeast India followed by its in vitro functional validation...
October 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29048972/new-persistent-opioid-use-among-patients-with-cancer-after-curative-intent-surgery
#11
Jay Soong-Jin Lee, Hsou Mei Hu, Anthony L Edelman, Chad M Brummett, Michael J Englesbe, Jennifer F Waljee, Jeffrey B Smerage, Jennifer J Griggs, Hari Nathan, Jacqueline S Jeruss, Lesly A Dossett
Purpose The current epidemic of prescription opioid misuse has increased scrutiny of postoperative opioid prescribing. Some 6% to 8% of opioid-naïve patients undergoing noncancer procedures develop new persistent opioid use; however, it is unknown if a similar risk applies to patients with cancer. We sought to define the risk of new persistent opioid use after curative-intent surgery, identify risk factors, and describe changes in daily opioid dose over time after surgery. Methods Using a national data set of insurance claims, we identified patients with cancer undergoing curative-intent surgery from 2010 to 2014...
October 19, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29048664/mir-25-promotes-metastasis-via-targeting-fbxw7-in-esophageal-squamous-cell-carcinoma
#12
Ye Hua, Kai Zhao, Gang Tao, Chunhua Dai, Yuting Su
Increasing evidence suggests that miR-25 can function as an oncogene in different types of human malignancies, whereas little is known concerning the role of miR-25 in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate the role of miR-25 in ESCC and to determine the molecular mechanisms underlying its function. The expression level of miR-25 was detected in primary ESCC tissues and cell lines by real-time quantitative PCR. We also assessed whether knockdown of miR-25 influences in vitro cell invasion and migration...
September 25, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29047233/overexpression-of-mir-191-predicts-poor-prognosis-and-promotes-proliferation-and-invasion-in-esophageal-squamous-cell-carcinoma
#13
Xiaotian Gao, Zhanqiang Xie, Zhigang Wang, Keluo Cheng, Ke Liang, Zeqing Song
PURPOSE: Accumulating evidence has shown that dysregulation of microRNA-191 (miR-191) is closely associated with tumorigenesis and progression in a wide range of cancers. This study aimed to explore the potential role of miR-191 in esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS: miR-191 expression was assessed in 93 ESCC tissue specimens by real-time polymerase chain reaction, and survival analysis was performed via Kaplan-Meier and Cox regression analyses...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29046800/re-irradiation-of-locoregional-esophageal-cancer-recurrence-following-definitive-chemoradiotherapy-a-report-of-6-cases
#14
Atsuto Katano, Hideomi Yamashita, Keiichi Nakagawa
There is currently no consensus on salvage therapy for recurrent esophageal cancer. Salvage surgery is a well-established option for attaining long-term survival; however, it is associated with a high risk of perioperative morbidity and mortality. A total of 6 patients who underwent re-irradiation for recurrence of locoregional esophageal cancer following definitive chemoradiotherapy were investigated. The median interval between initial radiotherapy and re-irradiation was 17.4 months (range, 6.4-59.2 months)...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29046751/case-series-of-multiple-primary-cancers-in-single-individuals-diagnostic-and-therapeutic-dilemmas
#15
Faizan Malik, Naveed Ali, Jibran Durrani, Syed Imran Mustafa, Crystal Denlinger
Background and Objectives: Cancer recurrence represents treatment failure; the development of new primary tumors is suggestive of persistent exposure to etiological risk factors or genetic predisposition due to mutations in multiple cell lines. Case presentation/Design/Methods: The first case is a 65-years-old Caucasian male who presented with esophageal and lung cancer diagnosed synchronously. Smoking was the common risk factor for both cancers, underscoring field cancerization. The diagnosis and management was a challenge and different from either cancer presenting alone...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29046735/identification-of-a-key-role-of-widespread-epigenetic-drift-in-barrett-s-esophagus-and-esophageal-adenocarcinoma
#16
E Georg Luebeck, Kit Curtius, William D Hazelton, Sean Maden, Ming Yu, Prashanthi N Thota, Deepa T Patil, Amitabh Chak, Joseph E Willis, William M Grady
BACKGROUND: Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences, and dynamics of epigenetic drift during carcinogenesis remain largely unexplored. Here we analyze the evolution of epigenetic drift patterns during progression from normal squamous esophagus tissue to Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) using 173 tissue samples from 100 (nonfamilial) BE patients, along with publically available datasets including The Cancer Genome Atlas (TCGA)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29046713/hpv-infection-and-p53-and-p16-expression-in-esophageal-cancer-are-they-prognostic-factors
#17
Allini Mafra da Costa, José Humberto Tavares Guerreiro Fregnani, Paula Roberta Aguiar Pastrez, Vânia Sammartino Mariano, Estela Maria Silva, Cristovam Scapulatempo Neto, Denise Peixoto Guimarães, Luisa Lina Villa, Laura Sichero, Kari Juhani Syrjanen, Adhemar Longatto-Filho
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic risk factors, alcohol and tobacco, but this hypothesis still remains contradictory. We sought to investigate wether HPV and well-known biomarkers (p16 and p53) and patient-related factors that may have impact on survival of ESCC. METHODS: We conducted a prospective cohort study...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29046712/integration-of-human-papillomavirus-16-in-esophageal-carcinoma-samples
#18
Shuying Li, Haie Shen, Zhanjun Liu, Ning Li, Suxian Yang, Ke Zhang, Jintao Li
BACKGROUND: Esophageal carcinoma (EC) is one of the major cancers in China. In 1982, Syrjanen first hypothesized the relationship between human papillomavirus (HPV) infection and the development of esophageal cancer. Since then, many reports in the field have supported this viewpoint. This study investigated the etiological relationship between HPV infection and the occurrence of esophageal carcinoma at Tangshan City of the Hebei province in China. METHODS: 189 samples of esophageal carcinoma patients were collected...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29045265/dose-escalation-study-of-concurrent-chemoradiotherapy-with-the-use-of-involved-field-conformal-radiotherapy-and-accelerated-hyperfractionation-in-combination-with-cisplatin-and-vinorelbine-chemotherapy-for-stage-iii-non-small-cell-lung-cancer-the-final-report
#19
Naruo Yoshimura, Takuhito Tada, Yoshiya Matsumoto, Kenji Sawa, Naoki Yoshimoto, Tomohiro Suzumura, Hidenori Tanaka, Shigeki Mitsuoka, Tatsuo Kimura, Tomohiro Tamiya, Tomonori Hirashima, Tomoya Kawaguchi, Shinzoh Kudoh, Masako Hosono, Kazuto Hirata
OBJECTIVES: A phase I study to determine a recommended dose of thoracic radiotherapy using accelerated hyperfractionation for unresectable non-small cell lung cancer was conducted. MATERIALS AND METHODS: We used chemotherapy of a cisplatin doublet and 2 dose levels of radiation with accelerated hyperfractionation. The radiation dose levels were: a total dose of 60 Gy in 40 fractions at level 1, and 66 Gy in 44 fractions at level 2. Eligible patients with unresectable stage III non-small cell lung cancer received cisplatin and vinorelbine...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29044576/long-term-outcomes-after-hand-sewn-versus-circular-stapled-25-and-29%C3%A2-mm-anastomotic-technique-after-esophagogastrectomy-for-esophageal-cancer
#20
Jack W Rostas, Beunca D Graffree, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
BACKGROUND: Anastomotic stricture following esophagogastrectomy (EG) can lead to significant dysphagia, necessitating interventions such as endoscopic dilatation. These post-operative complications gain importance with the increased survival rate of patients after EG. This study aimed to assess the outcomes of both circular-stapled (CS: 25 and 29 mm) and hand-sewn (HS) anastomoses after EG. METHODS: We reviewed prospectively accrued data from December 2004 to December 2014 identifying all patients undergoing EG for esophageal cancer...
October 16, 2017: Journal of Surgical Oncology
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