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https://www.readbyqxmd.com/read/29231542/-clinical-research-of-electroacupuncture-on-the-analgesic-effect-of-thoracic-perioperative-stage
#1
Mintao Zhou, Yu Li, Xuechang Han, Qunzhi Xing, Yiyao Wang, Xu Dong, Junxiao Chang
OBJECTIVE: To discuss the clinical therapeutic effects of electroacupuncture at Neimadian (Extra) and Neiguan (PC 6) on the analgesic effect of thoracic perioperative stage and its effect mechanism. METHODS: Sixty cases of esophageal cancer with elective radical resection under general anesthesia were divided into an observation group and a control group according to the operation sequence, 30 cases in each one. In the control group, the general anesthesia was simply applied and sufentanil was administered for patient controlled intravenous analgesia (PCIA) after operation...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29228994/survival-and-prognostic-factors-of-non-small-cell-lung-cancer-patients-with-postoperative-locoregional-recurrence-treated-with-radical-radiotherapy
#2
Li Ma, Bo Qiu, Jun Zhang, Qi-Wen Li, Bin Wang, Xu-Hui Zhang, Meng-Yun Qiang, Zhao-Lin Chen, Su-Ping Guo, Hui Liu
BACKGROUND: Locoregional recurrence remains the challenge for long-term survival of non-small cell lung cancer (NSCLC) patients after radical surgery, and curative-intent radiotherapy could be a treatment choice. This study aimed to assess the survival and prognostic factors of patients with postoperative locoregionally recurrent NSCLC treated with radical radiotherapy. METHODS: We reviewed medical records of 74 NSCLC patients with postoperative locoregional recurrence who received radical radiotherapy between April 2012 and February 2016 at Sun Yat-sen University Cancer Center (Guangzhou, China)...
December 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29228742/pretreatment-nutritional-risk-scores-and-performance-status-are-prognostic-factors-in-esophageal-cancer-patients-treated-with-definitive-chemoradiotherapy
#3
Tao Song, Qiuyan Wan, Wenke Yu, Jianbo Li, Shaohua Lu, Chen Xie, Hongqing Wang, Min Fang
This study evaluated the prognostic effects of nutritional risk scores and performance status (PS) on unresectable locally advanced esophageal cancer (LAEC) patients who were treated with definitive concurrent chemoradiotherapy (dCRT). A total of 202 LAEC patients from four different cancer centers were retrospectively reviewed. Nutritional risk and PS were measured using the Nutritional Risk Screening 2002 (NRS-2002) scores and Eastern Cooperative Oncology Group (ECOG) scales. Outcomes were clinical response rate, overall survival (OS) and progression-free survival (PFS)...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228166/long-term-results-of-concurrent-chemoradiotherapy-with-daily-low-dose-continuous-infusion-of-5-fluorouracil-and-cisplatin-ldfp-for-stage-i-ii-esophageal-carcinoma
#4
A Kumabe, J Fukada, R Kota, N Koike, Y Shiraishi, S Seki, K Yoshida, Y Kitagawa, N Shigematsu
We investigated long-term treatment outcomes and the feasibility of chemoradiotherapy consisting of daily-low-dose 5-fluorouracil and cisplatin (LDFP) chemotherapy plus radiotherapy for Stage I-II squamous cell esophageal cancer. Treatment records from the 2000 through 2008 period were reviewed retrospectively. Fractionated radiotherapy was performed with a total dose of 60 Gy delivered in 2 Gy per fraction. LDFP chemotherapy, as continuous infusion of 200 mg/m2 5-fluorouracil combined with one hour infusion of 4 mg/m2 cisplatin, was administered on the same days as radiotherapy...
December 8, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29227857/salvage-esophagectomy-with-pancreatectomy-for-local-recurrence-of-thoracic-esophageal-cancer-after-definitive-chemoradiotherapy-a-case-report
#5
Noriyuki Nishiwaki, Yasuhiro Tsubosa, Masahiro Niihara
INTRODUCTION: We encountered a case of advanced thoracic esophageal cancer in which R0 resection was achieved by salvage esophagectomy with pancreatectomy, but relapse occurred in the early postoperative phase. PRESENTATION OF CASE: A 64-year-old man with lower intrathoracic esophageal cancer received chemoradiotherapy, and a complete response was achieved. Subsequently, however, lymph node relapse, with infiltration into the pancreas, was observed. Thus, subtotal esophageal resection, total gastrectomy, distal pancreatectomy, and splenectomy were performed...
December 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29227754/genetic-variant-in-mir-124-decreased-the-susceptibility-to-esophageal-squamous-cell-carcinoma-in-a-chinese-kazakh-population
#6
Fei Wu, Mei Li, Weiyan You, Yu Ji, Xiaobin Cui, Jianming Hu, Yunzhao Chen, Lijuan Pang, Shugang Li, Yutao Wei, Lan Yang, Feng Li
AIMS: Esophageal squamous cell carcinoma (ESCC) is characterized by high prevalence and mortality worldwide, and it is very highly prevalent in China. ESCC is caused by various factors, including microRNAs (miRNAs) whose expression have been shown to play a major role in tumor generation. Single nucleotide polymorphisms (SNPs) in miRNAs could affect susceptibility to numerous cancers. This study aimed to evaluate the relationship between SNPs in miR-124 and ESCC risk in the Chinese Kazakh population...
December 11, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29226993/genetic-polymorphisms-of-microrna-machinery-genes-predict-overall-survival-of-esophageal-squamous-carcinoma
#7
Cuiju Wang, Hailing Dong, Haiyan Fan, Jianhua Wu, Guiying Wang
BACKGROUND: MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) in miRNA processing machinery genes are implicated in carcinogenesis, as they change the expression profiles of miRNA. Six miR-SNPs in miRNA processing machinery genes, including Dicer (rs3742330), RAN (rs14035), XPO5 (rs11077), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), were evaluated for their association with esophageal squamous cell carcinoma (ESCC). METHODS: The miR-SNP of the miRNA processing genes were genotyped using the polymerase chain reaction-ligase detection reaction (PCR-LDR) assay, while the XPO5 expression levels in ESCC tissues were measured by immunochemistry methods...
December 11, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29225860/massive-hemorrhage-following-definitive-esophageal-chemoradiation-teaching-case-of-a-fatal-aortoesophageal-fistula-and-lessons-learned
#8
Gwendolyn J McGinnis, John M Holland, Charles R Thomas, Nima Nabavizadeh
Esophageal self-expandable metal stents and radiotherapy are valuable in combination for palliation and definitive treatment of esophageal cancer. However, risk of aortoesophageal fistula is significant in patients with evidence of malignant aortic invasion. Use of thoracic endovascular repair may represent an approach to early intervention in high-risk patients.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29224264/-comparison-of-the-prognostic-value-of-the-seventh-and-eighth-edition-of-the-ajcc-esophageal-cancer-staging-system-for-the-patients-with-stage-%C3%A2-and-%C3%A2-esophageal-squamous-cell-carcinoma
#9
H Zhong, R Ma, L Gong, C G Chen, P Tang, P Ren, H J Jiang, Z T Yu
Objective: To compare and evaluate the prognostic value of the 7(th) and 8(th) edition of The AJCC Esophageal Cancer Staging System for patients with stage Ⅱ and Ⅲ esophageal squamous cell carcinoma. Methods: The clinical data of 328 esophageal cancer patients who received operation at Department of Esophageal Cancer, Tianjin Tumour Hospital from January 2006 to December 2010 were restrospectively analyzed. There were 63 female and 265 male patients. The mean age was 65 (range: 33 to 87) years. Univariate and multivariate analysis were performed to identify the prognosis factors...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29224262/-discussion-of-n-staging-category-of-the-eighth-edition-of-the-ajcc-esophageal-cancer-staging-system
#10
W P Wang, Y S Yang, S L He, L Q Chen
AJCC Esophageal Cancer Staging System, 8(th) edition will be implemented on January 1, 2018. The N staging in 8(th) edition of staging system remains following 7(th) edition based on the number of metastatic nodes, except the limited revision of the regional lymph node map. N staging revision was reviewed from the simple definition of negative (N0) and positive (N1) lymph node(s) to the positive node number based proposal (7(th) edition). The 7(th) edition staging system, especially the N staging, were proved with more advantages on distinguishing disease progression and predicting prognosis of the esophageal cancer...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29223420/her2-confers-resistance-to-foretinib-inhibition-of-met-amplified-esophageal-adenocarcinoma-cells
#11
Alexei A Goltsov, Bingliang Fang, Tej K Pandita, Dipen M Maru, Stephen G Swisher, Wayne L Hofstetter
BACKGROUND: Recent genomic studies indicated that esophageal adenocarcinoma (EAC) is driven by amplification of c-MET or HER2 or both in a subset of patients. We studied the effect of MET targeting by the small molecule inhibitor foretinib in EAC cells and the interplay between MET and HER2 signaling. METHODS: We measured the expression levels and phosphorylation status of MET and HER2 proteins in EAC cell lines using Western blot analysis. The expression levels of MET and HER2 were manipulated by transfecting cells with specific siRNA or a plasmid expressing HER2...
December 6, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29223141/molecular-and-functional-characterization-of-choline-transporter-like-proteins-in-esophageal-cancer-cells-and-potential-therapeutic-targets
#12
Fumiaki Nagashima, Ryohta Nishiyama, Beniko Iwao, Yuiko Kawai, Chikanao Ishii, Tsuyoshi Yamanaka, Hiroyuki Uchino, Masato Inazu
In this study, we examined the molecular and functional characterization of choline uptake in the human esophageal cancer cells. In addition, we examined the influence of various drugs on the transport of [3H]choline, and explored the possible correlation between the inhibition of choline uptake and apoptotic cell death. We found that both choline transporter-like protein 1 (CTL1) and CTL2 mRNAs and proteins were highly expressed in esophageal cancer cell lines (KYSE series). CTL1 and CTL2 were located in the plasma membrane and mitochondria, respectively...
December 8, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29223109/genome-wide-analysis-of-barrett-s-adenocarcinoma-a-first-step-towards-identifying-patients-at-risk-and-developing-therapeutic-paths
#13
Yiyang Dai, Qing Wang, Adrian Gonzalez Lopez, Mario Anders, Peter Malfertheiner, Michael Vieth, Wolfgang Kemmner
BACKGROUND: Barrett's esophagus metaplasia is the key precursor lesion of esophageal adenocarcinoma. The aim of this study was to find a subset of markers that may allow the identification of patients at risk for esophageal adenocarcinoma, and to determine genes differentially expressed in esophageal squamous cell carcinoma. METHODS: Laser capture microdissection technique was applied to procure cells from defined regions. Genome-wide RNA profiling was performed on esophageal adenocarcinoma (n = 21), Barrett's esophagus (n = 20), esophageal squamous carcinoma (n = 9) and healthy esophageal biopsies (n = 18) using the Affymetrix Human Genome U133plus 2...
December 6, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29222890/home-enteral-nutrition-after-minimally-invasive-esophagectomy-can-improve-quality-of-life-and-reduce-the-risk-of-malnutrition
#14
Zixiang Wu, Ming Wu, Qi Wang, Tianwei Zhan, Lian Wang, Saibo Pan, Gang Chen
BACKGROUND AND OBJECTIVES: The potential benefits of home enteral nutrition (HEN) and the effects of HEN on quality of life (QOL) after esophagectomy remain unclear. The aim was to investigate the effect of 3 months HEN on health related QOL and nutritional status of esophageal cancer patients who were preoperatively malnourished. METHODS AND STUDY DESIGN: 142 malnourished (PG-SGA stage B or C) patients with esophageal cancer were assigned to receive Ivor Lewis minimally invasive esophagectomy (MIE group) with laparoscopic jejunal feeding tube placement or open esophagectomy (OE group) with nasojejunal feeding tube placement...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222587/gastrointestinal-manifestation-of-immunoglobulin-g4-related-disease-clarification-through-a-multicenter-survey
#15
Kenji Notohara, Terumi Kamisawa, Kazushige Uchida, Yoh Zen, Mitsuhiro Kawano, Satomi Kasashima, Yasuharu Sato, Masahiro Shiokawa, Takeshi Uehara, Hajime Yoshifuji, Hiroko Hayashi, Koichi Inoue, Keisuke Iwasaki, Hiroo Kawano, Hiroyuki Matsubayashi, Yukitoshi Moritani, Katsuhiko Murakawa, Yoshio Oka, Masatoshi Tateno, Kazuichi Okazaki, Tsutomu Chiba
BACKGROUND: Several reports on immunoglobulin (Ig)G4-related disease (IgG4-RD) with gastrointestinal involvement (IgG4-related gastrointestinal disease; IgG4-GID) have been published, although this entity has not been fully established clinicopathologically. Thus, we carried out a multicenter survey. METHODS: Patients with possible IgG4-GID who underwent resection were collected. Histologic slides were reevaluated, and eight cases with diffuse lymphoplasmacytic infiltration but without numerous neutrophils, granulations or epithelioid granulomas were further analyzed...
December 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29221296/prognostic-role-of-initial-pan-endoscopic-tumor-length-at-diagnosis-in-operable-esophageal-squamous-cell-carcinoma-undergoing-esophagectomy-with-or-without-neoadjuvant-concurrent-chemoradiotherapy
#16
Chen-Sung Lin, Chao-Yu Liu, Chih-Tao Cheng, Yu-Chen Tsai, Lun-Wei Chiou, Ming-Yuan Lee, Chia-Chuan Liu, Chih-Hsun Shih
Background: The objective of this study was to appraise the prognostic role of initial pan-endoscopic tumor length at diagnosis within or between operable esophageal squamous cell carcinoma (ESCC) undergoing upfront esophagectomy or neoadjuvant concurrent chemoradiotherapy (nCCRT) followed by esophagectomy. Methods: Between Jan 2001 and Dec 2013 in Koo-Foundation Sun Yat-sen Cancer Center in Taiwan, 101 ESCC patients who underwent upfront esophagectomy (surgery group) and 128 nCCRT followed by esophagectomy (nCCRT-surgery group) were retrospectively collected...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221291/airway-stenting-in-patients-requiring-intubation-due-to-malignant-airway-stenosis-a-10-year-experience
#17
Masahide Oki, Hideo Saka, Kazumi Hori
Background: Critically ill patients with severe acute respiratory failure due to malignant airway stenosis often require emergency intubation and mechanical ventilation. Urgent intervention is necessary for the survival of such patients. The aim of this study was to determine the efficacy and outcomes of airway stenting in patients with malignant airway stenosis requiring emergency intubation. Methods: Patients with malignant airway stenosis who underwent emergency intubation prior to airway stent placement from September 2005 to September 2015 in a single center were retrospectively reviewed...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221284/comparison-of-perioperative-outcomes-following-hybrid-minimally-invasive-versus-open-ivor-lewis-esophagectomy-for-esophageal-cancer
#18
Ju Sik Yun, Kook Joo Na, Sang Yun Song, Seok Kim, In Seok Jeong, Sang Gi Oh
Background: The outcomes of various minimally invasive esophagectomy (MIE) procedures for esophageal cancer have been reported; however, those of the hybrid approach are lacking. This study aimed to assess the impacts of hybrid minimally invasive Ivor Lewis esophagectomy (HIL, laparoscopy and right thoracotomy) for esophageal cancer on perioperative outcomes compared with the open approach. Methods: This was a retrospective study of 153 patients who underwent Ivor Lewis esophagectomy for squamous cell carcinoma between January 2008 and December 2016...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221275/patterns-of-distant-organ-metastases-in-esophageal-cancer-a-population-based-study
#19
Dashan Ai, Hanting Zhu, Wenjia Ren, Yun Chen, Qi Liu, Jiaying Deng, Jinjun Ye, Jianhong Fan, Kuaile Zhao
Background: Esophageal cancer is the eighth most common cancer worldwide. The prognosis of esophageal cancer patients is dismal, especially those with distant organ metastasis. However, there are few studies describing the patterns of distant metastasis in esophageal cancer systematically. Methods: We gathered the data from Surveillance Epidemiology and End Results (SEER) database between 2010 and 2013. Categorical variables were analyzed by the Pearson Chi square test, and continuous variables were analyzed by the two-sample t test...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221273/clinical-outcomes-of-video-assisted-thoracoscopic-surgery-esophagectomy-for-esophageal-cancer-a-propensity-score-matched-analysis
#20
Duk Hwan Moon, Jong Mog Lee, Jae Hyun Jeon, Hee Chul Yang, Moon Soo Kim
Background: Minimally invasive esophagectomy theoretically offers advantages compared with open esophagectomy (OE). The aim of this study was to compare the early- and mid-term outcomes between video-assisted thoracoscopic surgery (VATS) esophagectomy (VE) and OE in patients with esophageal cancer. Methods: Between November 2011 and July 2015, a total of 172 patients were divided into two groups depending on the method of esophagectomy: the VE group (n=42) and the OE group (n=130)...
September 2017: Journal of Thoracic Disease
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