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https://www.readbyqxmd.com/read/28100387/-economic-burden-of-esophageal-cancer-in-china-from-1996-to-2015-a-systematic-review
#1
L W Guo, C L Shi, H Y Huang, L Wang, X P Yue, S Z Liu, J Li, K Su, M Dai, X B Sun, J F Shi
Objective: To explore existing evidence of economic burden of esophageal cancer in China over the past 20 years. Methods: Based on PubMed, CNKI and Wanfang, literatures published from 1996 to 2015 were retrieved with the key words such as " economic burden" , "cost of illness" and so on. Then the information excerpted from those literatures were analyzed after several exclusionary procedures for non-esophageal cancer related literatures. The information about subjects and data source, methodology, main results were structurally abstracted and then analyzed...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100369/-innovations-on-technology-management-and-concept-are-indispensible-for-scientific-research-prevention-and-treatment-of-malignant-tumor-in-china
#2
G W Cao
Malignant tumor has become the top cause of deaths before the average life expectancy in Chinese population. From the variations in the morbidity rate and mortality rate of malignant tumor in the mainland of China between 2000 and 2011, the primary prevention targeting the risk factors/etiological agents significantly reduced the morbidity rates of gastric cancer, esophageal cancer, and primary liver cancer, therefore reduced the mortality rates of these cancers. However, the contribution of clinical treatments to the mortality reduction was not obviously improved during this period...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28099899/concurrent-neoadjuvant-chemoradiotherapy-could-improve-survival-outcomes-for-patients-with-esophageal-cancer-a-meta-analysis-based-on-random-clinical-trials
#3
REVIEW
Baoxing Liu, Yacong Bo, Kunlun Wang, Yang Liu, Xiance Tang, Yan Zhao, Erjiang Zhao, Ling Yuan
BACKGROUND: The long-term survival benefit of concurrent neoadjuvant chemoradiotherapy in patients with resectable esophageal cancer remains controversial. In the present study, we conducted a meta-analysis to assess these effectiveness. METHODS: We searched for most relevant studies published up to the end of August 2016, using Pubmed and web of knowledge. And additional articles were identified from previous meta-analysis. The hazard ratio (HR, for overall survival and progression free survival) or risk ratio (RR, for R0 resection) with its corresponding 95 % confidence interval (CI) were used to assess the pooled effect...
January 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28099140/telomerase-antagonist-imetelstat-increases-radiation-sensitivity-in-esophageal-squamous-cell-carcinoma
#4
Xuping Wu, Jing Zhang, Sijun Yang, Zhihui Kuang, Guolei Tan, Gang Yang, Qichun Wei, Zhigang Guo
The morbidity and mortality of esophageal cancer is one of the highest around the world and the principal therapeutic method is radiation. Thus, searching for sensitizers with lower toxicity and higher efficiency to improve the efficacy of radiation therapy is critical essential. Our research group has previously reported that imetelstat, the thio-phosphoramidate oligonucleotide inhibitor of telomerase, can decrease cell proliferation and colony formation ability as well as increase DNA breaks induced by radiation in esophageal cancer cells...
January 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28098886/novel-zinc-phthalocyanine-as-a-promising-photosensitizer-for-photodynamic-treatment-of-esophageal-cancer
#5
Weronika Kuzyniak, Jacob Schmidt, Wojciech Glac, Janine Berkholz, Gustav Steinemann, Björn Hoffmann, Eugeny A Ermilov, Ayşe Gül Gürek, Vefa Ahsen, Bianca Nitzsche, Michael Höpfner
Photodynamic therapy (PDT) has gathered much attention in the field of cancer treatment and is increasingly used as an alternative solution for esophageal cancer therapy. However, there is a constant need for improving the effectiveness and tolerability of the applied photosensitizers (PS). Here, we propose tetra-triethyleneoxysulfonyl substituted zinc phthalocyanine (ZnPc) as a promising PS for photodynamic treatment of esophageal cancer. ZnPc-induced phototoxicity was studied in two human esophageal cancer cell lines: OE-33 (adenocarcinoma) and Kyse-140 (squamous cell carcinoma)...
January 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28097441/elevated-preoperative-neutrophil-to-lymphocytes-ratio-predicts-poor-prognosis-after-esophagectomy-in-t1-esophageal-cancer
#6
Kenichi Nakamura, Naoya Yoshida, Yoshifumi Baba, Keisuke Kosumi, Tomoyuki Uchihara, Yuki Kiyozumi, Mayuko Ohuchi, Takatsugu Ishimoto, Masaaki Iwatsuki, Yasuo Sakamoto, Masayuki Watanabe, Hideo Baba
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) has been reported to predict the prognosis of various malignant tumors, including esophageal cancer. However, no previous reports have supported the use of the preoperative NLR as an independent prognostic marker focused on superficial (T1) esophageal cancer. The aim of this study was to elucidate the prognostic impact of the preoperative NLR in T1 esophageal cancer. METHODS: This retrospective study recruited 245 consecutive patients with T1 esophageal cancer who underwent subtotal esophagectomy between 2005 and 2016...
January 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28096828/intramural-esophageal-tumors
#7
Mariusz P Łochowski, Katarzyna Kozak, Marek Rębowski, Józef Kozak
INTRODUCTION: Intramural esophageal tumors (IET) are located between unchanged mucous membrane and muscularis mucosae. They can be both benign and malignant. AIM: To evaluate diagnostic and therapeutic difficulties of IET. MATERIAL AND METHODS: During the years 2010-2015, 11 patients with IET were treated in our clinic. Diagnostics included gastroscopy, computed tomography of the chest, endoscopic ultrasound (EUS) guided fine needle biopsy, and positron emission tomography (PET) of the esophagus in cases with no histopathological confirmation...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28095111/increased-numb-protein-expression-predicts-poor-clinical-outcomes-in-esophageal-squamous-cell-carcinoma-patients
#8
Zhenguo Liu, Canqiao Luo, Weixiong Yang, Kefeng Wang, Chuang Hu, Jianyong Zou, Hua Zhu, Liwu Fu, Jing Nie, Chao Cheng
Numb is a protein whose asymmetric segregation during cell division determines cell fate and has numerous functions relevant to multiple fields of study, including developmental neurobiology and cancer biology. Little is known about the role of Numb in esophageal squamous cell carcinoma (ESCC), the predominant histological esophageal carcinoma in Asian populations. In this study, we focused on the expression and biological functions of Numb in the context of ESCC. From analysis of tissue microarrays with 212 patients, it was found that Numb was significantly upregulated in ESCC tissues compared to corresponding non-cancerous tissues...
January 17, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28092855/lc-ms-ms-determination-of-d-mannose-in-human-serum-as-a-potential-cancer-biomarker
#9
Lyndsey White, Jing Ma, Su Liang, Beatriz Sanchez-Espiridion, Dong Liang
Several metabolites in human serum have been identified as potential cancer biomarkers for early detection. This study focuses on the LC-MS/MS method development and validation of d-mannose in human serum. Surrogate blank serum, coupled with stable isotope d-mannose-(13)C6, as internal standard, was used for generating standard curves ranging from 1 to 50μg/mL. Separation was achieved by an Agilent 1200 series HPLC equipped with a SUPELCOGELTM Pb, 6% Crosslinked column with HPLC water as a mobile phase at flow rate of 0...
December 28, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28091898/the-outcomes-of-radiotherapy-and-factors-that-predict-overall-survival-in-elderly-patients-with-esophageal-squamous-cell-carcinoma
#10
H Yin, M E, H Zhang, C Wang
PURPOSE: The aim of this study was to evaluate radiotherapy in terms of both feasibility and efficacy for the treatment of 206 elderly patients (≥70 years) with unresectable ESCC and to investigate the factors that predict overall survival in those patients. METHODS: Totally, 206 elderly patients with esophageal cancer (≥70 years) treated with RT for ESCC in the Harbin Medical University Affiliated Tumor Hospital were retrospectively enrolled. Radiation treatment results and side effects were evaluated...
January 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28088657/early-adulthood-body-mass-index-cumulative-smoking-and-esophageal-adenocarcinoma-survival
#11
Anna Spreafico, Linda Coate, Rihong Zhai, Wei Xu, Zheng-Fei Chen, Zhuo Chen, Devalben Patel, Brandon Tse, M Catherine Brown, Rebecca S Heist, Lorin Dodbiba, Jennifer Teichman, Matthew Kulke, Li Su, Lawson Eng, Jennifer Knox, Rebecca Wong, Gail E Darling, David C Christiani, Geoffrey Liu
BACKGROUND: Smoking and obesity are esophageal adenocarcinoma (EAC) risk factors. However, the same risk factors may also affect biological aggressiveness and cancer outcomes. Our study evaluated the combined effects of early-adulthood obesity and cumulative smoking on the EAC survival. PATIENTS AND METHODS: In two EAC cohorts, Toronto (TO; N=235) and Boston (BO; N=329), associations between early adulthood body mass index (EA-BMI), BMI at 1year prior to diagnosis (BMI-1), and smoking with overall survival (OS) were assessed using Cox proportional hazard models, adjusted for relevant covariates...
January 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28086855/postoperative-fluid-overload-is-a-risk-factor-for-adverse-surgical-outcome-in-patients-undergoing-esophagectomy-for-esophageal-cancer-a-retrospective-study-in-335-patients
#12
Torben Glatz, Birte Kulemann, Goran Marjanovic, Svenja Bregenzer, Frank Makowiec, Jens Hoeppner
BACKGROUND: Restrictive intraoperative fluid management is increasingly recommended for patients undergoing esophagectomy. Controversy still exists about the impact of postoperative fluid management on perioperative outcome. METHODS: We retrospectively examined 335 patients who had undergone esophagectomy for esophageal cancer at the University Hospital Freiburg between 1996 and 2014 to investigate the relation between intra- and postoperative fluid management and postoperative morbidity after esophagectomy...
January 13, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28086818/narrow-band-imaging-versus-lugol-chromoendoscopy-to-diagnose-squamous-cell-carcinoma-of-the-esophagus-a-systematic-review-and-meta-analysis
#13
Flavio Hiroshi Ananias Morita, Wanderley Marques Bernardo, Edson Ide, Rodrigo Silva Paula Rocha, Julio Cesar Martins Aquino, Mauricio Kazuyoshi Minata, Kendi Yamazaki, Sergio Barbosa Marques, Paulo Sakai, Eduardo Guimarães Hourneaux de Moura
BACKGROUND: In the early stage esophageal cancer, changes in the mucosa are subtle and pass unnoticed in endoscopic examinations using white light. To increase sensitivity, chromoscopy with Lugol's solution has been used. Technological advancements have led to the emergence of virtual methods of endoscopic chromoscopy, including narrow band imaging (NBI). NBI enhances the relief of the mucosa and the underlying vascular pattern, providing greater convenience without the risks inherent to the use of vital dye...
January 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28079794/interventional-pulmonology-for-patients-with-central-airway-obstruction-an-8-year-institutional-experience
#14
Chia-Hung Chen, Biing-Ru Wu, Wen-Chien Cheng, Chih-Yu Chen, Wei-Chun Chen, Te-Chun Hsia, Wei-Chih Liao, Chih-Yen Tu, Wu-Huei Hsu
Patients with central airway obstruction (CAO) may need endobronchial intervention to relieve their symptoms. This report is on a single-center experience of using interventional bronchoscopy in terms of complications and survival. This retrospective study was conducted in a university hospital and involved 614 patients (464 men, 150 women; mean age, 60.2 years) with benign (n = 133) and malignant (n = 481) tracheobronchial disease who received 756 endobronchial intervention procedure during the period 2008 to 2015...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28078471/effects-of-estrogen-on-esophageal-function-through-regulation-of-ca-2-related-proteins
#15
Kipung Kim, Dongoh Lee, Changhwan Ahn, Hee Young Kang, Beum-Soo An, Yeon Hee Seong, Eui-Bae Jeung
BACKGROUND: The calcium ion is important for physiological functions in all tissues and organs and essential to many vital functions, including hormone secretion and muscle contraction. The intracellular concentration of calcium is regulated by calcium related proteins such as CaBP-9k, PMCA1, and NCX1. In this study, we investigated the relationship between calcium regulation and esophageal functions such as mucin secretion and smooth muscle contraction. METHODS: To evaluate the influence of sex steroid hormones, immature rats were treated for 3 days with estradiol (E2), progesterone (P4), and their antagonists (ICI 182,780, and RU486)...
January 11, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28078458/superiority-of-laparoscopic-proximal-gastrectomy-with-hand-sewn-esophagogastrostomy-over-total-gastrectomy-in-improving-postoperative-body-weight-loss-and-quality-of-life
#16
Tatsuto Nishigori, Hiroshi Okabe, Shigeru Tsunoda, Hisashi Shinohara, Kazutaka Obama, Hisahiro Hosogi, Shigeo Hisamori, Kikuko Miyazaki, Takeo Nakayama, Yoshiharu Sakai
BACKGROUND: Proximal gastrectomy is not widely performed because the procedure is complicated, particularly under laparoscopy. We developed a simple laparoscopic technique of hand-sewn esophagogastrostomy with an anti-reflux mechanism. This study aimed to evaluate and compare the postoperative body weight loss (BWL) and quality of life (QOL) following laparoscopic proximal gastrectomy (LPG) and laparoscopic total gastrectomy (LTG) in patients with upper gastric cancer. METHODS: We retrospectively analyzed patients with stage I upper gastric cancer undergoing LPG or LTG at Kyoto University Hospital between March 2006 and June 2014...
January 11, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28078443/double-stenting-with-silicone-and-metallic-stents-for-malignant-airway-stenosis
#17
Keitaro Matsumoto, Naoya Yamasaki, Tomoshi Tsuchiya, Takuro Miyazaki, Ryotaro Kamohara, Go Hatachi, Takeshi Nagayasu
For severe malignant airway stenosis, there are several types of commercially available airway stents, and each has its own advantages and disadvantages. We herein describe the safety and efficacy of combination stenting with silicone and metallic stents for patients with extended malignant airway stenosis. Seven patients with malignant airway stenosis were treated via combination stenting with a silicone stent and a metallic stent for extended airway stenosis from the central to peripheral airways. Five patients were diagnosed with advanced esophageal cancer, two of whom had tracheoesophageal fistulas...
January 11, 2017: Surgery Today
https://www.readbyqxmd.com/read/28078110/radioembolization-with-90-y-glass-microspheres-for-the-treatment-of-unresectable-metastatic-liver-disease-from-chemotherapy-refractory-gastrointestinal-cancers-final-report-of-a-prospective-pilot-study
#18
Nicholas Fidelman, Robert K Kerlan, Randall A Hawkins, Miguel Pampaloni, Andrew G Taylor, Maureen P Kohi, K Pallav Kolli, Chloe E Atreya, Emily K Bergsland, R Kate Kelley, Andrew H Ko, W Michael Korn, Katherine Van Loon, Ryan M McWhirter, Jennifer Luan, Curt Johanson, Alan P Venook
BACKGROUND: This prospective pilot single-institution study was undertaken to document the feasibility, safety, and efficacy of radioembolization of liver-dominant metastatic gastrointestinal cancer using (90)Y glass microspheres. METHODS: Between June 2010 and October 2013, 42 adult patients (26 men, 16 women; median age 60 years) with metastatic chemotherapy-refractory unresectable colorectal (n=21), neuroendocrine (n=11), intrahepatic bile duct (n=7), pancreas (n=2), and esophageal (n=1) carcinomas underwent 60 lobar or segmental administrations of (90)Y glass microspheres...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28077159/concurrent-chemoradiotherapy-combined-with-enteral-nutrition-support-a-radical-treatment-strategy-for-esophageal-squamous-cell-carcinoma-patients-with-malignant-fistulae
#19
Li Ma, Guang-Yu Luo, Yu-Feng Ren, Bo Qiu, Hong Yang, Chun-Xia Xie, Song-Ran Liu, Shi-Liang Liu, Zhao-Lin Chen, Qun Li, Jian-Hua Fu, Meng-Zhong Liu, Yong-Hong Hu, Wen-Feng Ye, Hui Liu
BACKGROUND: Concurrent chemoradiotherapy (CCRT) significantly increases the survival rate of esophageal squamous cell carcinoma (ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long-term survival. METHODS: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat-sen University Cancer Center between January 2010 and December 2012...
January 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28077137/aberrant-methylation-of-dact1-and-dact2-are-associated-with-tumor-progression-and-poor-prognosis-in-esophageal-squamous-cell-carcinoma
#20
Yan-Li Guo, Bao-En Shan, Wei Guo, Zhi-Ming Dong, Zhen Zhou, Su-Peng Shen, Xin Guo, Jia Liang, Gang Kuang
BACKGROUND: The DACT (Dishevelled-associated antagonist of β-catenin) family of scaffold proteins may play important roles in tumorigenesis. However, the epigenetic changes of DACT1, 2, 3 and their effect on esophageal squamous cell carcinoma (ESCC) have not been investigated so far. The aim of this study was to investigate the promoter methylation and expression of DACT family, in order to elucidate more information on the role of DACT with regard to the progression and prognosis of ESCC...
January 11, 2017: Journal of Biomedical Science
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