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Esophageal cancer

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https://www.readbyqxmd.com/read/28542983/sterilization-of-tumor-positive-lymph-nodes-of-esophageal-cancer-by-neo-adjuvant-treatment-is-associated-with-worse-survival-compared-to-tumor-negative-lymph-nodes-treated-with-surgery-first
#1
Styliani Mantziari, Pierre Allemann, Michael Winiker, Christine Sempoux, Nicolas Demartines, Markus Schäfer
BACKGROUND AND OBJECTIVES: Lymph node (LN) involvement by esophageal cancer is associated with compromised long-term prognosis. This study assessed whether LN downstaging by neoadjuvant treatment (NAT) might offer a survival benefit compared to patients with a priori negative LN. METHODS: Patients undergoing esophagectomy for cancer between 2005 and 2014 were screened for inclusion. Group 1 included cN0 patients confirmed as pN0 who were treated with surgery first, whereas group 2 included patients initially cN+ and down-staged to ypN0 after NAT...
May 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28542283/shared-susceptibility-loci-at-2q33-region-for-lung-and-esophageal-cancers-in-high-incidence-areas-of-esophageal-cancer-in-northern-china
#2
Xue Ke Zhao, Yi Min Mao, Hui Meng, Xin Song, Shou Jia Hu, Shuang Lv, Rang Cheng, Tang Juan Zhang, Xue Na Han, Jing Li Ren, Yi Jun Qi, Li Dong Wang
BACKGROUND: Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk candidate single nucleotide polymorphisms (SNPs). Thus, the present study aimed to determine the risk of these SNPs predisposing to lung cancer in Chinese population. METHODS: A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China...
2017: PloS One
https://www.readbyqxmd.com/read/28540761/current-and-future-treatment-options-for-esophageal-cancer-in-the-elderly
#3
Elfriede Bollschweiler, Patrick Plum, Stefan P Mönig, Arnulf H Hölscher
Esophageal cancer is the eighth most common cancer globally and has the sixth worst prognosis because of its aggressiveness and poor survival. Data regarding cancer treatment in older patients is limited because the elderly have been under-represented in clinical trials. Therefore, we reviewed the existing literature regarding treatment results for elderly patients (70+ years). Areas covered: We used pubmed to analyze the actual literature according to elderly esophageal cancer patients with subheading of incidence, esophagectomy, chemoradiation or chemotherapy...
May 25, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28539329/aberrant-methylation-mediated-silencing-of-lncrna-meg3-functions-as-a-cerna-in-esophageal-cancer
#4
Zhiming Dong, Aili Zhang, Shengnan Liu, Fan Lu, Yanli Guo, Guoqiang Zhang, Fenglou Xu, Yabin Shi, Supeng Shen, Jia Liang, Wei Guo
Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), has tumor suppressor properties and its expression is lost in several human tumors. However, its biological role in esophageal squamous cell carcinoma (ESCC) tumorigenesis is poorly defined. The present study determined the role and methylation status of MEG3 in esophageal cancer cells and ESCC clinical specimens, and further observed the competing endogenous RNA (ceRNA) activity of MEG3 in the pathogenesis and development of ESCC. Significant down-regulation of MEG3 was detected in esophageal cancer cells and ESCC tissues and the expression level of MEG3 was significantly increased in cancer cells after treated with the DNA methyltransferase inhibitor 5-Aza-dC...
May 24, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28539264/op16-a-novel-ent-kaurene-diterpenoid-potentiates-the-antitumor-effect-of-rapamycin-by-inhibiting-rapamycin-induced-feedback-activation-of-akt-signaling-in-esophageal-squamous-cell-carcinoma
#5
Ke-Zheng Peng, Yu Ke, Qi Zhao, Fei Tian, Hong-Min Liu, Guiqin Hou, Zhaoming Lu
Hyperactivation of mTOR signaling pathway has been viewed as a significant molecular pathogenesis of cancer. However, inhibition of mTOR by rapamycin and its analogs could induce numerous negative feedback loops to attenuate their therapeutic efficacy. As a traditional Chinese herbal medicine, Rabdosia rubescens has been used to treat esophageal squamous cell carcinoma (ESCC) for hundreds of years, and its major effective component is oridonin. Here we reported that OP16, a novel analog of oridonin, showed potent inhibition of cell proliferation and Akt phosphorylation in ESCC cells...
May 21, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28537901/inflammatory-cytokines-are-associated-with-response-and-prognosis-in-patients-with-esophageal-cancer
#6
Susanne Blank, Henrik Nienhüser, Lena Dreikhausen, Leila Sisic, Ulrike Heger, Katja Ott, Thomas Schmidt
BACKGROUND: Esophageal cancer is often marked by aggressive tumor growth and poor prognosis. Patient groups who benefit from perioperative therapy are not yet defined. The tumor microenvironment and circulating factors as possible predictors of response and prognosis gain interest. This study aimed to investigate cytokines in patients' serum and tumor tissue with regard to response and prognosis. RESULTS: Median survival between SCC and AC was not different (published previously)...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28537764/gefitinib-and-egfr-gene-copy-number-aberrations-in-esophageal-cancer
#7
Russell D Petty, Asa Dahle-Smith, David A J Stevenson, Aileen Osborne, Doreen Massie, Caroline Clark, Graeme I Murray, Susan J Dutton, Corran Roberts, Irene Y Chong, Wasat Mansoor, Joyce Thompson, Mark Harrison, Anirban Chatterjee, Stephen J Falk, Sean Elyan, Angel Garcia-Alonso, David Walter Fyfe, Jonathan Wadsley, Ian Chau, David R Ferry, Zosia Miedzybrodzka
Purpose The Cancer Esophagus Gefitinib trial demonstrated improved progression-free survival with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib relative to placebo in patients with advanced esophageal cancer who had disease progression after chemotherapy. Rapid and durable responses were observed in a minority of patients. We hypothesized that genetic aberration of the EGFR pathway would identify patients benefitting from gefitinib. Methods A prespecified, blinded molecular analysis of Cancer Esophagus Gefitinib trial tumors was conducted to compare efficacy of gefitinib with that of placebo according to EGFR copy number gain (CNG) and EGFR, KRAS, BRAF, and PIK3CA mutation status...
May 24, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28536494/adjuvant-chemotherapy-with-paclitaxel-and-cisplatin-in-lymph-node-positive-thoracic-esophageal-squamous-cell-carcinoma
#8
Liangze Zhang, Weiwei Li, Xiao Lyu, Yan Song, Yousheng Mao, Shaoming Wang, Jing Huang
OBJECTIVE: No standard postoperative adjuvant chemotherapy has ever been established in node-positive esophageal squamous cell carcinoma (ESCC). This is a study to explore the effect of postoperative paclitaxel (PTX) and cisplatin (DDP) in lymph node-positive, completely resected thoracic ESCC patients. METHODS: We conducted a prospective phase II trial. Patients had pathologically node-positive thoracic ESCC with negative margins. Outcomes of disease-free survival (DFS) and overall survival (OS) were compared with a matched historical control cohort...
April 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28535004/peroxiredoxin-5-overexpression-enhances-tumorigenicity-and-correlates-with-poor-prognosis-in-gastric-cancer
#9
Bokyung Kim, Yeon Soo Kim, Hye-Mi Ahn, Hyo Jin Lee, Min Kyu Jung, Hyun Yong Jeong, Dong Kyu Choi, Jun Hyeog Lee, Sang-Rae Lee, Jin Man Kim, Dong-Seok Lee
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Despite the advanced surgical resection techniques and anticancer drugs currently available to treat early stage gastric cancer, the prognosis of patients with gastric cancer remains poor. The epithelial to mesenchymal transition (EMT) is an important process for the initiation of tumorigenesis. Recent studies suggested that reactive oxygen species (ROS) can promote cell migration and invasion. Thus, an imbalance of redox homeostasis can result in cancer cells exhibiting EMT properties...
May 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28534990/tumor-suppressor-microrna-34a-inhibits-cell-migration-and-invasion-by-targeting-mmp-2-mmp-9-fndc3b-in-esophageal-squamous-cell-carcinoma
#10
Lan Yang, Xiaoyue Song, Jianbo Zhu, Mei Li, Yu Ji, Fei Wu, Yunzhao Chen, Xiaobin Cui, Jianming Hu, Lianghai Wang, Yuwen Cao, Yutao Wei, Wenjie Zhang, Feng Li
MicroRNAs (miRNAs) are a large family of small, non-coding RNAs that play a pivotal role in tumorigenesis. miR‑34a, which is a member of the miR-34 family, is a downstream target of p53. Increasing evidence shows that miR-34a dysregulation may contribute to tumor development and progression in numerous cancers, including esophageal squamous cell carcinoma (ESCC). However, the mechanism of miR-34a in the regulation of ESCC cells need to be further elucidated because of the complex regulative network of miRNAs...
May 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28534989/enhanced-cancer-stem-cell-properties-of-a-mitotically-quiescent-subpopulation-of-p75ntr-positive-cells-in-esophageal-squamous-cell-carcinoma
#11
Hirofumi Kojima, Tomoyuki Okumura, Tetsuji Yamaguchi, Takeshi Miwa, Yutaka Shimada, Takuya Nagata
Mitotically quiescent cancer stem cells (CSCs) possess higher malignant potential than other CSCs, indicating their higher contribution to therapeutic resistance than that of other CSCs. In esophageal squamous cell carcinoma (ESCC), p75 neurotrophin receptor (p75NTR) is expressed in a candidate CSC population showing high tumorigenicity and chemoresistance. In the present study, we isolated and characterized quiescent CSCs population in ESCC based on p75NTR expression and cell cycle status. Expression of p75NTR and Ki-67 in ESCC cell lines (KYSE cells) and surgically resected ESCC specimens was detected by performing immunocytochemical analysis...
May 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28533658/checkpoint-inhibitors-in-gastrointestinal-cancers-expectations-and-reality
#12
EDITORIAL
Hampig Raphael Kourie, Samer Tabchi, Marwan Ghosn
Immune checkpoint inhibitors represent revolutionary anti-cancer agents, being rapidly approved in different malignancies and settings. Gastrointestinal (GI) cancers represent a wide variety of tumors with specific characteristics and different responses to various therapeutic alternatives; while some are chemo-sensitive others are chemo-resistant and only respond to more aggressive cytotoxic regimens, targeted therapies or a combination of both. Preliminary results of immune checkpoint inhibitors in some GI cancers are promising, namely in hepatocellular carcinoma, anal cancers and microsatellite instability high colorectal cancers...
May 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28533408/rna-editing-of-slc22a3-drives-early-tumor-invasion-and-metastasis-in-familial-esophageal-cancer
#13
Li Fu, Yan-Ru Qin, Xiao-Yan Ming, Xian-Bo Zuo, Yu-Wen Diao, Li-Yi Zhang, Jiaoyu Ai, Bei-Lei Liu, Tu-Xiong Huang, Ting-Ting Cao, Bin-Bin Tan, Di Xiang, Chui-Mian Zeng, Jing Gong, Qiangfeng Zhang, Sui-Sui Dong, Juan Chen, Haibo Liu, Jian-Lin Wu, Robert Z Qi, Dan Xie, Li-Dong Wang, Xin-Yuan Guan
Like many complex human diseases, esophageal squamous cell carcinoma (ESCC) is known to cluster in families. Familial ESCC cases often show early onset and worse prognosis than the sporadic cases. However, the molecular genetic basis underlying the development of familial ESCC is mostly unknown. We reported that SLC22A3 is significantly down-regulated in nontumor esophageal tissues from patients with familial ESCC compared with tissues from patients with sporadic ESCCs. A-to-I RNA editing of the SLC22A3 gene results in its reduced expression in the nontumor esophageal tissues of familial ESCCs and is significantly correlated with lymph node metastasis...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28532543/-overexpression-of-olc1-in-lung-squamous-cell-carcinoma-tissues-is-associated-with-poor-prognosis-of-patients
#14
Kunpeng Zhang, Gefei Zhao, Ting Xiao, Ping Li, Jie Song, Yanning Gao, Kelin Sun
BACKGROUND: OLC1 (overexpressed in lung cancer 1), screened out and cloned in our previous research, is a new gene associated with lung cancer. It is highly expressed in lung cancer and many other malignant tumors, and is associated with poor prognosis of esophageal squamous cell carcinoma, ovarian cancer, breast cancer and colorectal cancer. The aim of this research was to detect the expression level of OLC1 in the tumor tissues of lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) and explore its relationship with the prognosis of lung cancer patients...
May 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28532174/subsequent-thoracic-cancers-among-patients-diagnosed-with-lung-cancer-a-seer-database-analysis
#15
Omar Abdel-Rahman, Winson Cheung
BACKGROUND: Population-based data on the development of subsequent thoracic cancers following the initial diagnosis of lung cancer are scarce. We evaluated this clinical scenario in lung cancer patients registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database (1988-2013) was queried using the SEER*Stat program to determine the clinico-pathological features of lung cancer patients who develop subsequent thoracic cancers as well as the characteristics of these subsequent cancers...
May 22, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28531452/the-effect-of-glutamine-and-arginine-enriched-nutritional-support-on-quality-of-life-in-head-and-neck-cancer-patients-treated-with-imrt
#16
Sezin Yuce Sari, Gozde Yazici, Deniz Yuce, Erdem Karabulut, Mustafa Cengiz, Gokhan Ozyigit
BACKGROUND AND AIMS: Oral mucositis and esophagitis are common acute toxicities of radiotherapy (RT) for head and neck cancer (HNC). In order to decrease the rates of these toxicities, we compared quality of life in HNC patients that did and did not receive a glutamine and arginine-enriched solution (GAES) during RT. METHODS: A total of 29 patients received intensity-modulated radiotherapy (IMRT); 15 used GAES b.i.d. during the treatment, and a matched cohort of 14 patients did not...
December 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28530542/a-comparison-of-the-toxicity-of-mono-bis-tris-and-tetrakis-phosphino-silver-complexes-on-sno-esophageal-cancer-cells
#17
Zelinda Engelbrecht, Kariska Potgieter, Zenele Mpela, Rehana Malgas-Enus, Reinout Meijboom, Marianne J Cronje
Several silver(I) triphenylphosphine adducts were prepared as 1:1 to 1:4 ratios of silver nitrate to triphenylphosphine were used to determine their anticancer activity in a malignant SNO esophageal cell line. The silver-phosphine adducts include: [Ag(PPh3)]NO3 (1); [Ag(PPh3)2]NO3 (2); [Ag(PPh3)3]NO3 (3) and [Ag(PPh3)4]NO3 (4). In addition, the activity of 1-4 where compared to previously reported complexes [Ag(Ph2P(CH2)2PPh2)2]NO3 (5) and [Ag(Ph2P(CH2)3PPh2)2]NO3 (6). The cytotoxicity of complexes 1 to 6 was also evaluated in non-malignant human dermal fibroblast cells (HDF-a)...
May 22, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28529620/the-relation-of-hpv-infection-and-expression-of-p53-and-p16-proteins-in-esophageal-squamous-cells-carcinoma
#18
Paula Roberta Aguiar Pastrez, Vânia Sammartino Mariano, Allini Mafra da Costa, Estela Maria Silva, Cristovam Scapulatempo-Neto, Denise Peixoto Guimarães, Gilberto Fava, Said Abdala Zemi Neto, Emily Montosa Nunes, Laura Sichero, Luisa Lina Villa, Kari Juhani Syrjanen, Adhemar Longatto-Filho
GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53 protein levels were assessed by immunohistochemistry (IHC). RESULTS: High-risk HPV (hr-HPV) was found in the same frequency (13.8%) in esophageal squamous cell carcinoma (ESCC) and in healthy individuals...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28529615/a-novel-blood-tool-of-cancer-prognosis-in-esophageal-squamous-cell-carcinoma-the-fibrinogen-albumin-ratio
#19
Zihui Tan, Man Zhang, Qiang Han, Jing Wen, Kongjia Luo, Peng Lin, Lanjun Zhang, Hong Yang, Jianhua Fu
Background: Coagulation and nutrition play important roles in cancer progression. We aim to investigate the impact of the fibrinogen/albumin ratio(FAR) in esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed 1135 patients with radical esophagectomy for ESCC from January 2008 to December 2010 in our center. X-tile software was used to determine the optimal cutoff levels for these biomarkers. Results: The optimal cutoff value was 0.08 for the FAR by the X-tile software. The FAR was statistically significantly associated with age(p=0...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28529610/foretinib-enhances-the-radiosensitivity-in-esophageal-squamous-cell-carcinoma-by-inhibiting-phosphorylation-of-c-met
#20
Guang-Zong Chen, Wang-Shu Dai, Hong-Cheng Zhu, Hong-Mei Song, Xi Yang, Yuan-Dong Wang, Hua Min, Qian Lu, Shu Liu, Xin-Chen Sun, Xiao-Ning Zeng
As a crucial event involved in the metastasis and relapse of esophageal cancer, c-Met overexpression has been considered as one of the culprits responsible for the failure in patients who received radiochemotherapy. Since c-Met has been confirmed to be pivotal for cell survival, proliferation and migration, little is known about its impact on the regulation of radiosensitivity in esophageal cancer. The present study investigated the radiosensitization effects of c-Met inhibitor foretinib in ECA-109 and TE-13 cell lines...
2017: Journal of Cancer
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