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https://www.readbyqxmd.com/read/28945004/tlr3-contributes-to-persistent-autophagy-and-heart-failure-in-mice-after-myocardial-infarction
#1
Ting Gao, Shao-Ping Zhang, Jian-Fei Wang, Li Liu, Yin Wang, Zhi-Yong Cao, Qi-Kuan Hu, Wen-Jun Yuan, Li Lin
Toll-like receptors (TLRs) are essential immunoreceptors involved in host defence against invading microbes. Recent studies indicate that certain TLRs activate immunological autophagy to eliminate microbes. It remains unknown whether TLRs regulate autophagy to play a role in the heart. This study examined this question. The activation of TLR3 in cultured cardiomyocytes was observed to increase protein levels of autophagic components, including LC3-II, a specific marker for autophagy induction, and p62/SQSTM1, an autophagy receptor normally degraded in the final step of autophagy...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944937/individual-development-and-potential-determinants-of-excess-weight-in-children-and-adolescents-a-longitudinal-study
#2
Alexandra Papandreou, Matthias Bopp, Julia Braun, Kaspar Staub, David Faeh
OBJECTIVES: Excess body weight is a major public health concern already at a young age. The aim of this study was to track weight status among pupils aged 6-14 years in the City of Zurich, to examine the association between sociodemographic and environmental factors and excess weight at school entry and excess weight gain thereafter. DESIGN: Longitudinal study. SETTING: Data were from the medical examinations routinely performed at public schools in Zurich, the largest city in Switzerland...
September 25, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28944845/efficient-inhibition-of-duck-hepatitis-b-virus-dna-by-the-crispr-cas9-system
#3
Qingfen Zheng, Li Bai, Sujun Zheng, Mei Liu, Jinyan Zhang, Ting Wang, Zhongwei Xu, Yu Chen, Jiansheng Li, Zhongping Duan
Current therapeutic strategies cannot eradicate hepatitis B virus covalently closed circular DNA (HBV cccDNA), which accounts for the persistence of HBV infection. Very recently, the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‑associated protein 9 (Cas9) system has been used as an efficient and powerful tool for viral genome editing. Given that the primary duck hepatocyte (PDH) infected with duck hepatitis B virus (DHBV) has been widely used to study human HBV infection in vitro, the present study aimed to demonstrate the targeted inhibition of DHBV DNA, especially cccDNA, by the CRISPR/Cas9 system using this model...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944721/early-life-sugar-consumption-has-long-term-negative-effects-on-memory-function-in-male-rats
#4
Emily E Noble, Ted M Hsu, Joanna Liang, Scott E Kanoski
OBJECTIVES: Added dietary sugars contribute substantially to the diet of children and adolescents in the USA, and recent evidence suggests that consuming sugar-sweetened beverages (SSBs) during early life has deleterious effects on hippocampal-dependent memory function. Here, we test whether the effects of early-life sugar consumption on hippocampal function persist into adulthood when access to sugar is restricted to the juvenile/adolescent phase of development. METHODS: Male rats were given ad libitum access to an 11% weight-by-volume sugar solution (made with high fructose corn syrup-55) throughout the adolescent phase of development (post-natal day (PN) 26-56)...
September 25, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28944686/remission-of-chronic-headache-rates-potential-predictors-and-the-role-of-medication-follow-up-results-of-the-german-headache-consortium-ghc-study
#5
Verena Henning, Zaza Katsarava, Mark Obermann, Susanne Moebus, Sara Schramm
Objectives To estimate remission rates of chronic headache (CH), focusing on potential predictors of headache remission and medication. Methods We used data from the longitudinal population-based German Headache Consortium (GHC) Study (n = 9,944, 18-65 years). Validated questionnaires were used at baseline (t0, 2003-2007, response rate: 55.2%), first follow-up after 1.87 ± 0.39 years (t1, 37.2%) and second follow-up after 3.26 ± 0.60 years (t2, 38.8%) to assess headache type and frequency, use of analgesics and anti-migraine drugs, medication overuse, education, BMI, smoking and alcohol consumption...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28944561/impact-of-persistent-and-non-persistent-generic-escherichia-coli-and-salmonella-sp-recovered-from-a-beef-packing-plant-on-biofilm-formation-by-e-coli-o157
#6
Jeyachchandran Visvalingam, Timothy C Ells, Xianqin Yang
AIMS: To examine the influence of meat plant E. coli and Salmonella sp. isolates on E. coli O157 biofilm formation. METHODS AND RESULTS: Biofilm formation was quantified by crystal violet staining (A570 nm ) and viable cell numbers for up to 6 days at 15°C. All five persistent E. coli genotypes formed strong biofilms when cultured alone or co-cultured with E. coli O157, with A570 nm values reaching ≥4.8 at day 4, while only two of five non-persistent genotypes formed such biofilms...
September 25, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28944558/imaging-the-neuroimmune-response-to-alcohol-exposure-in-adolescent-baboons-a-tspo-pet-study-using-18-f-dpa-714
#7
Wadad Saba, Sébastien Goutal, Sylvain Auvity, Bertrand Kuhnast, Christine Coulon, Virginie Kouyoumdjian, Irène Buvat, Claire Leroy, Nicolas Tournier
The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune system. The neuroimmune response to an initial and acute alcohol exposure was investigated using translocator protein 18 kDa (TSPO) PET imaging, a non-invasive marker of glial activation, in adolescent baboons. Three different alcohol-naive adolescent baboons (3-4 years old, 9 to 14 kg) underwent (18) F-DPA-714 PET experiments before, during and 7-12 months after this initial alcohol exposure (0...
September 25, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28944518/scenarios-reveal-pathways-to-sustain-future-ecosystem-services-in-an-agricultural-landscape
#8
Jiangxiao Qiu, Stephen R Carpenter, Eric G Booth, Melissa Motew, Samuel C Zipper, Christopher J Kucharik, Xi Chen, Steven P Loheide, Jenny Seifert, Monica G Turner
Sustaining food production, water quality, soil retention, flood and climate regulation in agricultural landscapes is a pressing global challenge given accelerating environmental changes. Scenarios are stories about plausible futures, and scenarios can be integrated with biophysical simulation models to explore quantitatively how the future might unfold. However, few studies have incorporated a wide range of drivers (e.g., climate, land-use, management, population, human diet) in spatially explicit, process-based models to investigate spatial-temporal dynamics and relationships of a portfolio of ecosystem services...
September 25, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28944450/review-dynamic-spatial-models-of-parasite-transmission-in-wildlife-their-structure-applications-and-remaining-challenges
#9
REVIEW
L A White, J D Forester, M E Craft
1.Individual differences in contact rate can arise from host, group, and landscape heterogeneity and can result in different patterns of spatial spread for diseases in wildlife populations with concomitant implications for disease control in wildlife of conservation concern, livestock, and humans. While dynamic disease models can provide a better understanding of the drivers of spatial spread, the effects of landscape heterogeneity have only been modelled in a few well-studied wildlife systems such as rabies and bovine tuberculosis...
September 25, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28944357/endodontic-retreatment-vs-dental-implants-of-teeth-with-an-uncertain-endodontic-prognosis-1-year-results-from-a-randomised-controlled-trial
#10
Marco Esposito, Marco Tallarico, Anna Trullenque-Eriksson, Rodolfo Gianserra
PURPOSE: To ascertain whether in the presence of a previously endodontically treated tooth with a periapical pathology and/or symptoms and an uncertain prognosis, it is better to endodontically retreat it or to replace the tooth with a single implant-supported crown. MATERIALS AND METHODS: Forty patients requiring the treatment of a previously endodontically treated tooth, with a periapical pathology and/or symptoms of endodontic origin and an uncertain prognosis, as judged by the recruiting investigators, were randomly allocated to endodontic retreatment (endo group; 20 patients) or tooth extraction and replacement with an implant-supported crown (implant group; 20 patients) according to a parallel group design at two different centres...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28944309/particle-coatings-but-not-silver-ions-mediate-genotoxicity-of-ingested-silver-nanoparticles-in-a-mouse-model
#11
Sameera Nallanthighal, Cadia Chan, Dhruba J Bharali, Shaker A Mousa, Elizabeth Vásquez, Ramune Reliene
Incorporation of silver nanoparticles (AgNPs) in toothpaste, food containers, dietary supplements and other consumer products can result in oral exposure to AgNPs and/or silver ions (Ag(+)) released from the surface of AgNPs. To examine whether ingestion of AgNPs or Ag(+) results in genotoxic damage and whether AgNP coatings modulate the effect, we exposed mice orally to 20 nm citrate-coated AgNPs, polyvinylpyrrolidone (PVP)-coated AgNPs, silver acetate or respective vehicles at a 4 mg/kg dose (equivalent to 800x the EPA reference dose for Ag) for 7 days...
January 2017: NanoImpact
https://www.readbyqxmd.com/read/28944227/neonatal-enterovirus-myocarditis-with-severe-dystrophic-calcification-novel-treatment-with-pocapavir
#12
Samuel G Wittekind, Catherine C Allen, John L Jefferies, Mantosh S Rattan, Peace C Madueme, BreAnn N Taylor, Ryan A Moore
Dystrophic myocardial calcification occurs in the setting of myocardial injury and normal serum calcium. We present a case of a neonate with prominent dystrophic calcification and severe left ventricular systolic dysfunction in the setting of enterovirus myocarditis. These findings are superbly illustrated by multiple imaging modalities. The patient was treated with the novel antiviral, pocapavir, in addition to a standard heart failure regimen. The dystrophic calcification persisted but the left ventricle remodeled significantly...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28944178/alcohol-septal-ablation-in-which-patients-and-why
#13
Paolo Spirito, Jessica Rossi, Barry J Maron
At present, surgical septal myectomy is regarded as the "gold standard" treatment for most patients with obstructive hypertrophic cardiomyopathy (HCM) and drug-refractory symptoms. However, the best results are obtained by those surgeons who have extensive experience with this operation at a small number of referral centers. In the mid-1990s, percutaneous alcohol septal ablation was introduced as an alternative to myectomy to reduce LV outflow gradient and heart failure symptoms in patients with obstructive HCM...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944165/sleep-trajectories-before-and-after-the-final-menstrual-period-in-the-study-of-women-s-health-across-the-nation-swan
#14
Howard M Kravitz, Imke Janssen, Joyce T Bromberger, Karen A Matthews, Martica H Hall, Kristine Ruppert, Hadine Joffe
PURPOSE OF REVIEW: Longitudinal studies show that the menopausal transition (MT) is associated with poorer self-reported sleep. Increases in sleep disturbances across and beyond the MT are strongly associated with vasomotor symptoms (VMS) but occur even without VMS. We analyzed data from baseline through 13 annual or biennial follow-up assessments from SWAN's multi-racial/ethnic cohort of midlife women, specifically focusing on patterns of sleep problems in the years preceding and following the final menstrual period (FMP)...
September 2017: Current Sleep Medicine Reports
https://www.readbyqxmd.com/read/28944158/environmental-chemicals-and-preterm-birth-biological-mechanisms-and-the-state-of-the-science
#15
Kelly K Ferguson, Helen B Chin
PURPOSE OF REVIEW: Preterm birth is a significant worldwide health problem of uncertain origins. The extant body of literature examining environmental contaminant exposures in relation to preterm birth is extensive but results remain ambiguous for most organic pollutants, metals and metalloids, and air pollutants. In the present review we examine recent epidemiologic studies investigating these associations, and identify recent advances and the state of the science. Additionally, we highlight biological mechanisms of action in the pathway between chemical exposures and preterm birth, including inflammation, oxidative stress, and endocrine disruption, that deserve more attention in this context...
March 2017: Current Epidemiology Reports
https://www.readbyqxmd.com/read/28944132/rapid-shelf-wide-cooling-response-of-a-stratified-coastal-ocean-to-hurricanes
#16
Greg Seroka, Travis Miles, Yi Xu, Josh Kohut, Oscar Schofield, Scott Glenn
Large uncertainty in the predicted intensity of tropical cyclones (TCs) persists compared to the steadily improving skill in the predicted TC tracks. This intensity uncertainty has its most significant implications in the coastal zone, where TC impacts to populated shorelines are greatest. Recent studies have demonstrated that rapid ahead-of-eye-center cooling of a stratified coastal ocean can have a significant impact on hurricane intensity forecasts. Using observation-validated, high-resolution ocean modeling, the stratified coastal ocean cooling processes observed in two U...
June 2017: Journal of Geophysical Research. Oceans
https://www.readbyqxmd.com/read/28944085/false-negative-transcranial-motor-evoked-potentials-tcmeps-during-surgery-for-congenital-lumbar-kyphoscoliosis-a-case-report
#17
Masayuki Ohashi, Kei Watanabe, Kenta Furutani, Toru Hirano, Keiichi Katsumi, Hirokazu Shoji, Tatsuki Mizouchi, Naoto Endo
INTRODUCTION: Transcranial motor evoked potential (TcMEP) monitoring is the gold standard for intra-operative neurological monitoring (IOM) of motor pathways during complex spine surgery because of its high sensitivity and specificity. However, although it is very low, the rate of false-negatives in TcMEP monitoring is not zero. Therefore, over-reliance on TcMEP monitoring can cause potentially preventable motor deficits. CASE PRESENTATION: We report a case of motor deficits due to nerve root stretch after surgical correction of a congenital lumbar kyphoscoliosis in a 56-year-old woman...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28944058/bioactive-mono-dispersed-nanospheres-with-long-term-antibacterial-effects-for-endodontic-sealing
#18
Xiaogang Cheng, Tiejun Qu, Chi Ma, Doudou Xiang, Qing Yu, Xiaohua Liu
Endodontic sealers with antibacterial capability play an important role in preventing reinfection of an endodontically treated root canal and improving the long-term success of root canal treatment. However, current endodontic sealers rapidly lose their antibacterial properties after fixation. In this work, we designed and synthesized quaternized mono-dispersed bioactive nanospheres as a potential substrate for the development of a long-term antibacterial endodontic sealer with excellent cytocompatibility and biocompatibility...
2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28944024/a-review-of-the-influence-of-biogeography-riverine-linkages-and-marine-connectivity-on-fish-assemblages-in-evolving-lagoons-and-lakes-of-coastal-southern-africa
#19
REVIEW
Alan K Whitfield, Steven P Weerts, Olaf L F Weyl
The Holocene evolution of eight South African coastal lakes and lagoons is examined and related to changes in fish composition over that period. Historical and current connectivity with riverine and marine environments are the primary determinants of present-day fish assemblages in these systems. A small and remarkably consistent group of relict estuarine species have persisted in these coastal lakes and lagoons. The loss or reduction of connectivity with the sea has impacted on the diversity of marine fishes in all eight study systems, with no marine fishes occurring in those water bodies where connectivity has been completely broken (e...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28944023/genetic-conservation-and-management-of-the-california-endemic-torrey-pine-pinus-torreyana-parry-implications-of-genetic-rescue-in-a-genetically-depauperate-species
#20
Jill A Hamilton, Raphaël Royauté, Jessica W Wright, Paul Hodgskiss, F Thomas Ledig
Rare species present a challenge under changing environmental conditions as the genetic consequences of rarity may limit species ability to adapt to environmental change. To evaluate the evolutionary potential of a rare species, we assessed variation in traits important to plant fitness using multigenerational common garden experiments. Torrey pine, Pinus torreyana Parry, is one of the rarest pines in the world, restricted to one mainland and one island population. Morphological differentiation between island and mainland populations suggests adaptation to local environments may have contributed to trait variation...
September 2017: Ecology and Evolution
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