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https://www.readbyqxmd.com/read/29793205/comprehensive-assessment-of-three-typical-antibiotics-on-cyanobacteria-microcystis-aeruginosa-the-impact-and-recovery-capability
#1
Yingxiang Du, Jing Wang, Fengyi Zhu, Dina Mai, Zhongrun Xiang, Jianqiu Chen, Ruixin Guo
This innovative study provided a comprehensive evaluation of the effects of three typical antibiotics exposures (cefradine, norfloxacin and amoxicillin) on Microcystis aeruginosa in two periods (exposure and post-exposure) at a new perspective. The results indicated that the irreversible growth inhibition of M. aeruginosa attributed to the norfloxacin in the exposure and the re-exposure stages. In contrast, although the algal cell size recovered to the control level after the exposure of 20 mg/L of cefradine, the significant stimulation on glutathione (GSH) still persisted even if the contaminants were removed...
May 21, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29793201/positive-effects-of-an-oil-adjuvant-on-efficacy-dissipation-and-safety-of-pyrimethanil-and-boscalid-on-greenhouse-strawberry
#2
Zhiwei Wang, Xinquan Wang, Tao Cang, Xueping Zhao, Shenggan Wu, Peipei Qi, Xiangyun Wang, Xiahong Xu, Qiang Wang
Methylated vegetable oil adjuvants can enhance initial deposition and decrease the required dosages of pesticides sprayed on plants, so an oil adjuvant mixed with fungicides were used to prevent and control gray mold in greenhouse strawberry. As the persistence and dietary exposure risks from fungicides on strawberries after using adjuvants have not been assessed, the efficacy, dissipation and safety of pyrimethanil and boscalid in the presence and absence of a methylated vegetable oil adjuvant were evaluated...
May 21, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29793149/educational-and-emotional-health-outcomes-in-adolescence-following-maltreatment-in-early-childhood-a-population-based-study-of-protective-factors
#3
Nisreen Khambati, Liam Mahedy, Jon Heron, Alan Emond
Although childhood maltreatment is associated with long-term impairment, some children function well despite this adversity. This study aimed to identify the key protective factors for good educational attainment and positive emotional health in adolescents who experienced maltreatment in early childhood. Data were analyzed from the Avon Longitudinal Study of Parents and Children, a large UK prospective cohort study. The sample was defined by maternally reported exposure to physical or emotional maltreatment by a parent prior to 5 years...
May 21, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29793115/estimating-chemical-ecotoxicity-in-eu-ecolabel-and-in-eu-product-environmental-footprint
#4
Erwan Saouter, An De Schryver, Rana Pant, Serenella Sala
The EU Commission Ecolabel and the Product and Environmental Footprint (PEF) aim at promoting the development and consumption of greener products. The product aquatic toxicity score from these 2 methods may lead in some circumstances to opposite conclusions. Although this could be interpreted as an inconsistency, the score should not be compared to each other but used in a complementary way. In short, CDV provided a "full" product formula aquatic toxicity score, even if some chemicals may never reach or persist in freshwater ecosystems...
May 21, 2018: Environment International
https://www.readbyqxmd.com/read/29793059/longitudinal-surveillance-of-drug-resistance-in-plasmodium-falciparum-isolates-from-the-china-myanmar-border-reveals-persistent-circulation-of-multidrug-resistant-parasites
#5
Yao Bai, Jiaqi Zhang, Jinting Geng, Shiling Xu, Shuang Deng, Weilin Zeng, Zenglei Wang, Huguette Gaelle Ngassa Mbenda, Jie Zhang, Na Li, Yanrui Wu, Cuiying Li, Huae Liu, Yonghua Ruan, Yaming Cao, Zhaoqing Yang, Liwang Cui
Multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion of Southeast Asia is a major threat to malaria elimination and requires close surveillance. In this study, we collected 107 longitudinal clinical samples of P. falciparum in 2007-2012 from the malaria hypoendemic region of the China-Myanmar border and measured their in vitro susceptibilities to 10 antimalarial drugs. Overall, parasites had significantly different IC50 values to all the drugs tested as compared to the reference 3D7 strain...
May 21, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29792996/cervical-bracing-practices-after-degenerative-cervical-surgery-a-survey-of-cervical-spine-research-society-members
#6
David J Lunardini, Martin H Krag, Nathan S Mauser, Joon Y Lee, William H Donaldson, James D Kang
BACKGROUND: Context: Prior studies have shown common use of post-operative bracing, despite advances in modern day instrumentation rigidity and little evidence of brace effectiveness. PURPOSE: To document current practice patterns of brace use after degenerative cervical spine surgeries among members of the Cervical Spine Research Society (CSRS), to evaluate trends, and to identify areas of further study. STUDY DESIGN: A questionnaire survey METHODS: A 10 question survey was sent to members of the Cervical Spine Research Society to document current routine bracing practices after various common degenerative cervical spine surgical scenarios, including fusion and non-fusion procedures...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792994/lumbar-spinal-stenosis-comparison-of-surgical-practice-variation-and-clinical-outcome-in-three-national-spine-registries
#7
Greger Lønne, Peter Fritzell, Olle Hägg, Dennis Nordvall, Paul Gerdhem, Tobias Lagerbäck, Mikkel Andersen, Søren Eiskjaer, Martin Gehrchen, Wilco Jacobs, Miranda L van Hooff, Tore K Solberg
BACKGROUND: Decompression surgery for lumbar spinal stenosis (LSS) is the most common spinal procedure in the elderly. To avoid persisting low back pain, adding arthrodesis has been recommended, especially if there is a coexisting degenerative spondylolisthesis. However, this strategy remains controversial, resulting in practice-based variation. PURPOSE: To evaluate in a pragmatic study if surgical selection criteria and variation in use of arthrodesis in three Scandinavian countries can be linked to variation in treatment effectiveness...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792972/association-between-early-confirmatory-testing-and-the-adoption-of-active-surveillance-for-men-with-favorable-risk-prostate-cancer
#8
Deborah R Kaye, Ji Qi, Todd M Morgan, Susan Linsell, Brian R Lane, James E Montie, Michael L Cher, David C Miller
OBJECTIVE: To examine the relationship between the use and results of early confirmatory testing and persistence on active surveillance (AS). METHODS: We identified all men in the MUSIC registry diagnosed with favorable-risk prostate cancer from 01/2016-02/2017. We next examined trends in the use of early confirmatory test(s), defined as repeat biopsy, prostate MRI and/or molecular classifiers obtained within 6-months of the initial cancer diagnosis, in patients with favorable-risk prostate cancer...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792945/cross-linking-by-epichlorohydrin-and-diepoxybutane-correlates-with-cytotoxicity-and-leads-to-apoptosis-in-human-leukemia-hl-60-cells
#9
Phuong M Le, Vanesa L Silvestri, Samuel C Redstone, Jordanne B Dunn, Julie T Millard
The bifunctional alkylating agents epichlorohydrin (ECH) and diepoxybutane (DEB) have been linked to increased cancer risks in industrial workers. These compounds react with DNA and proteins, leading to genotoxic effects. We used the comet assay to monitor formation of cross-links in HL-60 cells treated with ECH, DEB, and the structurally related anti-cancer drug mechlorethamine (HN2). We report a time- and dose-dependent cytotoxicity that correlated with cross-linking activity, following the order HN2 > DEB > ECH...
May 21, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29792875/modelling-the-skip-and-resurgence-of-japanese-encephalitis-epidemics-in-hong-kong
#10
Shi Zhao, Yijun Lou, Alice P Y Chiu, Daihai He
Japanese encephalitis virus (JEV) is a zoonotic mosquito-borne virus, persisting in pigs, Ardeid birds and Culex mosquitoes. It is endemic to China and Southeastern Asia. The case-fatality ratio (CFR) or the rate of permanent psychiatric sequelae is 30% among symptomatic patients. There were no reported local JEV human cases between 2006 to 2010 in Hong Kong, but it was followed by a resurgence of cases from 2011 to 2017. The mechanism behind this "skip-and-resurgence" patterns is unclear. This work aims to reveal the mechanism behind the "skip-and-resurgence" patterns using mathematical modelling and likelihood-based inference techniques...
May 21, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29792808/eradication-of-established-tumors-by-chemically-self-assembled-nanoring-csan-targeted-t-cells
#11
Jacob Petersburg, Jingjing Shen, Clifford M Csizmar, Katherine A Murphy, Justin Spanier, Kari Gabrielse, Thomas S Griffith, Brian Fife, Carston R Wagner
Our laboratory has developed chemically self-assembled nanorings (CSANs) as prosthetic antigen receptors (PARs) for the non-genetic modification of T-cell surfaces. PARs have been successfully employed in vitro to activate T cells for the selective killing of leukemia cells. However, PAR efficacy has yet to be evaluated in vivo or against solid tumors. Therefore, we developed bispecific PARs that selectively target the human CD3 receptor and human Epithelial Cell Adhesion Molecule (EpCAM), which is overexpressed on multiple carcinomas and cancer stem cells...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29792782/25-hydroxyvitamin-d3-and-1-25-dihydroxyvitamin-d3-as-an-antiviral-and-immunomodulator-against-herpes-simplex-virus-1-infection-in-hela-cells
#12
Archit Kumar, Mini P Singh, Ragini S Kumar, Radha Kanta Ratho
The antiviral and immunomodulatory role of vitamin D has been shown in various viral infections. However, there is scanty literature available about the effect of vitamin D supplementation in herpes simplex virus-1 (HSV-1) infection. Therefore, the present study aimed to evaluate the role of two different forms of vitamin D: 25-hydroxyvitamin D3 (25D3) and 1,25-dihydroxyvitamin D3 (1,25D3) against HSV-1 in HeLa cells. The HeLa cells were supplemented with either 25D3 or 1,25D3 before HSV-1 infection and were studied after 6, 12, and 24 h postinfection (p...
May 24, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29792536/outcomes-in-paediatric-external-dacryocystorhinostomy-a-single-centre-experience
#13
Tarjani Vivek Dave, Edak Ezeanosike, Milind N Naik, Mohammad Javed Ali
PURPOSE: To report the outcomes of external dacryocystorhinostomy (Ext DCR) in paediatric patients. METHODS: A single-centre, retrospective, interventional, non-comparative case series was performed on all paediatric patients who underwent Ext DCR between July 2010 and July 2014. Surgery was performed as per standard Ext DCR protocols with only anterior flap suturing. Data collected include demographics, clinical presentations, primary diagnosis, associated systemic anomalies, past interventions, indications for the surgery, use of adjuvants, intraoperative and post-operative complications, aetiology of DCR failure, anatomical and functional successes...
May 24, 2018: Orbit
https://www.readbyqxmd.com/read/29792499/teacher-and-student-race-as-a-predictor-for-negative-feedback-during-instruction
#14
Terrance M Scott, Nicholas Gage, Regina Hirn, HyunSuk Han
There is a long and persistent gap between the academic achievement of White and Black students in America's schools. Further, Black students are suspended from school at a rate that is more than three times greater than White students. While there has been some suggestion that perhaps teacher-student racial matching may be part of a solution, the research does not currently provide adequate support for teacher race alone to be sufficiently effective. This study analyzed 41 Black and White teacher-student dyad mixes in elementary schools and another 41 in a high school to examine how teacher and student race interact in terms of teacher and student behaviors...
May 24, 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29792441/human-memory-reconsolidation-a-guiding-framework-and-critical-review-of-the-evidence
#15
James W B Elsey, Vanessa A Van Ast, Merel Kindt
Research in nonhuman animals suggests that reactivation can induce a transient, unstable state in a previously consolidated memory, during which the memory can be disrupted or modified, necessitating a process of restabilization in order to persist. Such findings have sparked a wave of interest into whether this phenomenon, known as reconsolidation, occurs in humans. Translating research from animal models to human experiments and even to clinical interventions is an exciting prospect, but amid this excitement, relatively little work has critically evaluated and synthesized existing research regarding human memory reconsolidation...
May 24, 2018: Psychological Bulletin
https://www.readbyqxmd.com/read/29792314/severe-and-predominantly-active-atopic-eczema-in-adulthood-and-long-term-risk-of-cardiovascular-disease-population-based-cohort-study
#16
Richard J Silverwood, Harriet J Forbes, Katrina Abuabara, Anna Ascott, Morten Schmidt, Sigrún A J Schmidt, Liam Smeeth, Sinéad M Langan
OBJECTIVE: To investigate whether adults with atopic eczema are at an increased risk of cardiovascular disease and whether the risk varies by atopic eczema severity and condition activity over time. DESIGN: Population based matched cohort study. SETTING: UK electronic health records from the Clinical Practice Research Datalink, Hospital Episode Statistics, and data from the Office for National Statistics, 1998-2015. PARTICIPANTS: Adults with a diagnosis of atopic eczema, matched (on age, sex, general practice, and calendar time) to up to five patients without atopic eczema...
May 23, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29792260/widening-participation-of-m%C3%A4-ori-and-pasifika-students-in-health-careers-evaluation-of-two-health-science-academies
#17
Lesley Middleton, Ausaga Faasalele Tanuvasa, Megan Pledger, Nicola Grace, Kirsten Smiler, Tua Taueetia Loto-Su'a, Jacqueline Cumming
Objective The aim of the present study was to evaluate the short-term outcomes of two health science academies established by a district health board in South Auckland, New Zealand, to create a health workforce pipeline for local Māori and Pasifika students. Methods A mixed-methods approach was used, involving background discussions with key informants to generate an initial logic model of how the academies work, followed by secondary analysis of students' records relating to retention and academic achievement, a survey of senior academy students' interest in particular health careers and face-to-face interviews and focus groups with students, families and teachers...
May 24, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29792199/nanoparticle-delivery-of-grape-seed-derived-proanthocyanidins-to-airway-epithelial-cells-dampens-oxidative-stress-and-inflammation
#18
S Castellani, A Trapani, A Spagnoletta, L di Toma, T Magrone, S Di Gioia, D Mandracchia, G Trapani, E Jirillo, M Conese
BACKGROUND: Chronic respiratory diseases, whose one of the hallmarks is oxidative stress, are still incurable and need novel therapeutic tools and pharmaceutical agents. The phenolic compounds contained in grape are endowed with well-recognized anti-oxidant, anti-inflammatory, anti-cancer, and anti-aging activities. Considering that natural anti-oxidants, such as proanthocyanidins, have poor water solubility and oral bioavailability, we have developed a drug delivery system based on solid lipid nanoparticles (SLN), apt to encapsulate grape seed extract (GSE), containing proanthocyanidins...
May 23, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29792176/anti-neutrophil-cytoplasmic-antibody-associated-glomerulonephritis-with-detection-of-myeloperoxidase-and-phospholipase-a-2-receptor-in-membranous-nephropathy-lesions-report-of-two-patients-with-microscopic-polyangiitis
#19
Kenta Tominaga, Takahiro Uchida, Toshihiko Imakiire, Kenji Itoh, Hideyuki Shimazaki, Kuniaki Nakanishi, Hiroo Kumagai, Naoki Oshima
BACKGROUND: Podocyte phospholipase A2 receptor (PLA2 R) is a major target antigen in idiopathic adult membranous nephropathy (MN). Histological PLA2 R staining in the renal tissue has proven to be useful for the detection of idiopathic MN. However, glomerular PLA2 R deposits have also been recently observed in several patients with secondary MN, such as hepatitis B virus-associated, hepatitis C virus-associated, and neoplasm-associated MN. Certain inflammatory environments have been suggested to lead to abnormal expression of PLA2 R epitopes, with the resulting production of PLA2 R autoantibodies...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29792125/characteristics-of-apixaban-treated-patients-evaluation-of-the-dose-prescribed-and-the-persistence-of-treatment-a-cohort-study-in-catalonia
#20
Ainhoa Gomez-Lumbreras, Jordi Cortes, Maria Giner-Soriano, M Angeles Quijada-Manuitt, Rosa Morros
BACKGROUND: Apixaban is a direct oral anticoagulant, which inhibits factor Xa. It has demonstrated clinical efficacy in prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation and a better safety profile compared to warfarin. OBJECTIVES: (1) To describe the characteristics of patients with nonvalvular atrial fibrillation beginning treatment with apixaban, (2) to analyze concomitant prescriptions of medications that could potentially interact with apixaban, (3) to evaluate the level of appropriate usage according to the recommended dosage, and (4) to estimate the level of apixaban persistence among naive and non-naive patients...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
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