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https://www.readbyqxmd.com/read/28811185/the-effect-of-receptor-status-on-mastectomy-and-contralateral-prophylactic-mastectomy-rates-in-early-stage-invasive-breast-carcinoma
#1
Sunil W Dutta, Daniel M Trifiletti, Surbhi Grover, Kara D Romano, Einsley-Marie Janowski, Shayna L Showalter
BACKGROUND: There is an established relationship between hormone receptor (HR; estrogen and/or progesterone receptors) status, HER2 status, and locoregional recurrence. The purpose of this study was to analyze how HR and HER2 receptor status have influenced the surgical management trends among patients with early stage breast cancer. PATIENTS AND METHODS: The National Cancer Database was queried for patients with cT1 to cT3, cN0, and cM0 breast carcinoma from 2004 to 2012...
June 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28808428/a-comparison-of-concurrent-cisplatin-versus-cetuximab-with-radiotherapy-in-locally-advanced-head-and-neck-cancer-a-bi-institutional-analysis
#2
William A Stokes, Whitney A Sumner, Kiersten L Breggren, John T Rathbun, David Raben, Jessica D McDermott, Gregory Gan, Sana D Karam
AIM: To present our experience comparing cisplatin- and cetuximab-based radiotherapy for locally-advanced head and neck squamous cell carcinoma. BACKGROUND: The comparative effectiveness of cisplatin-based chemoradiotherapy (CRT) versus cetuximab-based bioradiotherapy (BRT) for locally-advanced head and neck squamous cell carcinoma (LAHNSCC) continues to be explored. MATERIALS AND METHODS: Outcomes of LAHNSCC patients treated with CRT (125) or BRT (34) at two institutions were compared retrospectively, with attention to overall survival (OS), cancer-specific survival (CSS), locoregional control (LRC), and distant control (DC)...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28807748/dosimetric-analysis-and-preliminary-clinical-result-of-image-guided-brachytherapy-with-or-without-hybrid-technique-for-cervical-cancer-using-varisource-titanium-ring-applicator-with-siriraj-ring-cap
#3
Pittaya Dankulchai, Suphalerk Lohasammakul, Janjira Petsuksiri, Pitchayut Nakkrasae, Lalida Tuntipumiamorn, Chumpot Kakanaporn, Yaowalak Chansilpa
PURPOSE: Titanium ring cap applicator (VariSource) was applied in treating cervical cancer patients by using image-guided brachytherapy (IGBT). However, its sizes appeared to be relatively large for most of our patients. Thus, we have developed a specific applicator "Siriraj Ring Cap," which is slightly smaller and more suitable for our patients. This study was to evaluate effectiveness of this equipment. METHODS AND MATERIALS: Locally advanced cervical cancer patients were treated with external beam radiation therapy with or without concomitant chemotherapy...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28807633/evaluating-the-effectiveness-of-prophylactic-central-neck-dissection-with-total-thyroidectomy-for-cn0-papillary-thyroid-carcinoma-an-update-meta-analysis
#4
REVIEW
W-J Zhao, H Luo, Y-M Zhou, W-Y Dai, J-Q Zhu
BACKGROUND: The effectiveness of prophylactic central neck dissection (pCND) following total thyroidectomy (TT) in patients with clinical node-negative (cN0) papillary thyroid carcinoma (PTC) is still controversial. The aim of the meta-analysis is to evaluate the outcome of pCND and provide quantitative evidence. METHOD: A detailed literature search of PubMed, EMBASE, ClinicalTrails.gov and Cochrane Library electronic databases for articles published until October 2016 was carried out...
August 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28807064/stage-is-a-prognostic-factor-for-surgically-treated-patients-with-early-stage-lip-cancer-for-whom-a-wait-and-see-policy-in-terms-of-neck-status-has-been-implemented
#5
G Eskiizmir, E Ozgur, G Karaca, P Temiz, N Hacioglu Yanar, B Cengiz Ozyurt
OBJECTIVES: To determine the locoregional control and survival rates (in terms of risk factors) of patients who underwent surgical resection of early-stage lip cancer and for whom a 'wait and see' policy in terms of neck status had been implemented. METHODS: The sociodemographic data, tumour stage, tumour characteristics and histopathological features of 41 patients with early-stage lip cancer were evaluated. Factors predictive of survival and locoregional recurrence were analysed...
August 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28806994/patterns-of-locoregional-failure-following-post-operative-intensity-modulated-radiotherapy-to-oral-cavity-cancer-quantitative-spatial-and-dosimetric-analysis-using-a-deformable-image-registration-workflow
#6
Abdallah S R Mohamed, Andrew J Wong, Clifton D Fuller, Mona Kamal, Gary B Gunn, Jack Phan, William H Morrison, Beth M Beadle, Heath Skinner, Stephen Y Lai, Sean R Quinlan-Davidson, Abdelaziz M Belal, Ahmed G El-Gowily, Steven J Frank, David I Rosenthal, Adam S Garden
BACKGROUND: We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer patients receiving post-operative IMRT (PO-IMRT). METHODS: Two hundred eighty-nine OCC patients receiving PO-IMRT were retrospectively reviewed from 2000 to 2012. Diagnostic CT documenting recurrence (rCT) was co-registered with planning CT (pCT) using a validated deformable image registration software. Manually segmented recurrent gross disease (rGTV) was deformed to co-registered pCTs...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28804666/primary-small-cell-carcinoma-of-the-hypopharynx-a-report-of-two-cases-and-review-of-nine-additional-cases
#7
Mitsuhiko Nakahira, Kiyomi Kuba, Satoko Matsumura, Masashi Sugasawa
OBJECTIVE: Two patients with primary small cell carcinoma (SmCC) of the hypopharynx, an extremely rare site for the occurrence of SmCC, are reported and nine additional well-documented cases are reviewed. METHODS: Case report and review of the literature concerning primary SmCC of the hypopharynx. RESULTS: On the final analysis, we reviewed eleven cases of primary SmCC of the hypopharynx. The tumors contained mixed elements of SmCC and squamous cell carcinoma (SCC) in six (55%) of eleven patients...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28803459/prediction-of-esophageal-stricture-in-patients-administered-locoregional-triamcinolone-injections-immediately-after-endoscopic-submucosal-dissection
#8
Yasuaki Nagami, Masaki Ominami, Masatsugu Shiba, Taishi Sakai, Shusei Fukunaga, Satoshi Sugimori, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Noriko Kamata, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Takuma Ishihara, Kouji Yamamoto, Yasuhiro Fujiwara
BACKGROUND AND AIM: Esophageal endoscopic submucosal dissection (ESD) to resect widespread lesions has increased the incidence of strictures, and some patients develop strictures despite receiving prophylactic locoregional triamcinolone injections. This study evaluated the predictive factors for esophageal stricture formation in patients administered prophylactic triamcinolone injections after ESD. METHODS: This was a retrospective observational study. Of 552 consecutive patients who underwent ESD, those who received prophylactic triamcinolone injections immediately after ESD were enrolled...
August 13, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28802913/salvage-high-dose-rate-brachytherapy-and-external-beam-radiotherapy-for-isolated-vaginal-recurrences-of-endometrial-cancer-with-no-prior-adjuvant-therapy
#9
Christopher H Chapman, Kaveh Maghsoudi, Ramey D Littell, Lee-May Chen, I-Chow Hsu
PURPOSE: To evaluate clinical outcomes for isolated vaginal recurrence of endometrial cancer without adjuvant therapy treated with salvage external beam radiation therapy (EBRT) and high-dose-rate CT-based inverse-planned brachytherapy. METHODS AND MATERIALS: Thirty women were included in this retrospective study. Median time to first recurrence was 16.7 months, and median age at recurrence was 73 years. Initial grade was 1 or 2 in 19 patients (63%), and 2009 FIGO stage IA in 19 patients...
August 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28802661/efficacy-of-isolated-limb-perfusion-ilp-in-patients-with-merkel-cell-carcinoma-mcc-a-multicenter-experience
#10
L M van Veenendaal, M F Madu, M E T Tesselaar, C Verhoef, D J Grünhagen, A C J van Akkooi
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and potentially aggressive neuroendocrine tumor of the skin, with a propensity for locoregional metastases. In two expert referral centers, isolated limb perfusion (ILP) is used to obtain locoregional control in selected locoregionally advanced MCC patients. This study describes our experience. METHOD: Patients who underwent ILP for MCC were analyzed. ILP was performed with melphalan and tumor necrosis factor (TNF) combination therapy...
August 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28801012/use-of-lymph-node-ultrasound-prior-to-sentinel-lymph-node-biopsy-in-384-patients-with-melanoma-a-cost-effectiveness-analysis
#11
D Olmedo, M Brotons-Seguí, C Del Toro, M González, C Requena, V Traves, A Pla, I Bolumar, D Moreno-Ramírez, E Nagore
BACKGROUND AND OBJECTIVES: Locoregional lymph node ultrasound is not typically included in guidelines as part of the staging process prior to sentinel lymph node biopsy (SLNB). The objective of the present study was to make a clinical and economic analysis of lymph node ultrasound prior to SLNB. MATERIALS AND METHODS: We performed a retrospective study of 384 patients with clinical stage I-II primary melanoma who underwent locorregional lymph node ultrasound (with or without ultrasound-guided biopsy) prior to SLNB between 2004 and 2015...
August 8, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28800049/survival-outcomes-following-aggressive-treatment-of-oligometastatic-breast-cancer-a-systematic-review-protocol
#12
Robyn Coombe, Karolina Lisy, Jared Campbell, Gajen Perry, Subhita Prasannan
The objective of this systematic review is to assess the effectiveness of aggressive treatment of oligometastatic breast cancer (OMBC) on survival outcomes by conducting a meta-analysis of current available evidence.More specifically, the objectives are to identify the effectiveness of intensified multidisciplinary treatment with aggressive locoregional therapies on survival time, five-year survival rates and disease free survival. The population is adult women (18 years and over) with OMBC defined as single or few (five or less) metastases limited to a single organ and the comparative group is conventional palliative treatment aimed at disease control...
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28799064/safety-and-efficacy-of-isolated-limb-infusion-chemotherapy-for-advanced-locoregional-melanoma-in-elderly-patients-an-australian-multicenter-study
#13
Hidde M Kroon, Brendon J Coventry, Mitchell H Giles, Michael A Henderson, David Speakman, Mark Wall, Andrew Barbour, Jonathan Serpell, Paul Paddle, Bernard M Smithers, John F Thompson
BACKGROUND: Isolated limb infusion (ILI) offers a minimally invasive treatment option for locally advanced extremity melanoma. OBJECTIVE: The aim of the current study was to evaluate the safety and efficacy of ILI in elderly patients in an Australian multicenter setting. METHODS: The results of 316 first ILI procedures, performed between 1992 and 2008 in five Australian institutions, were identified and analyzed, with the main focus on elderly patients (≥75 years of age)...
August 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28797467/outcomes-of-oral-cavity-cancer-patients-treated-with-surgery-followed-by-postoperative-intensity-modulated-radiation-therapy
#14
Sean R Quinlan-Davidson, Abdallah S R Mohamed, Jeffrey N Myers, Gary B Gunn, Faye M Johnson, Heath Skinner, Beth M Beadle, Ann M Gillenwater, Jack Phan, Steven J Frank, William N William, Andrew J Wong, Stephen Y Lai, Clifton D Fuller, William H Morrison, David I Rosenthal, Adam S Garden
OBJECTIVES: Although treatment paradigms have not changed significantly, radiotherapy, surgery, and imaging techniques have improved, leading us to investigate oncologic and survival outcomes for oral cavity squamous cell cancer (OCSCC) patients treated with surgery followed by postoperative IMRT. MATERIAL AND METHODS: Records of patients with pathological diagnosis of OCSCC treated between 2000 and 2012 were retrospectively reviewed. Patients' demographic, disease, and treatment criteria were extracted...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797461/the-importance-of-log-odds-of-positive-lymph-nodes-for-locoregional-recurrence-in-oral-squamous-cell-carcinoma
#15
Ali-Farid Safi, Martin Kauke, Andrea Grandoch, Hans-Joachim Nickenig, Uta Drebber, Joachim Zöller, Matthias Kreppel
OBJECTIVES: Log odds of positive lymph nodes (LODDS) has been demonstrated as a very promising staging model for multiple cancer sites, as it avoids singularity and predicts prognosis significantly better than conventional nodal staging and lymph node ratio. However, published studies on the influence of LODDS for patients with OSCC are very seldom. MATERIAL AND METHODS: Retrospective chart review of 499 patients with treatment-naive oral squamous cell carcinoma...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797445/characteristics-and-long-term-outcomes-of-head-and-neck-squamous-cell-carcinoma-after-solid-organ-transplantation
#16
Samer Alsidawi, Katharine A Price, Ashish V Chintakuntlawar, Gustavo F Westin, Joaquin J Garcia, Daniel J Ma, Scott H Okuno
INTRODUCTION: Immunosuppression after solid organ transplant prevents graft rejection, but leads to increased incidence of various malignancies including head and neck squamous cell carcinoma (HNSCC). Outcomes of patients with post-transplant HNSCC are unknown. MATERIALS AND METHODS: We retrospectively identified patients who developed HNSCC after solid organ transplant between 1995 and 2010. Adults with pathology-proven HNSCC and adequate follow up were included...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797119/a-retrospective-study-of-606-cases-of-nasopharyngeal-carcinoma-with-or-without-oropharyngeal-candidiasis-during-radiotherapy
#17
Wen-Ze Qiu, Liang-Ru Ke, Wei-Xiong Xia, Jing Yang, Ya-Hui Yu, Hu Liang, Xin-Jun Huang, Guo-Ying Liu, Wang-Zhong Li, Yan-Qun Xiang, Xiang Guo, Xing Lv
BACKGROUND: To evaluate the clinical characteristics, treatment-related toxicities and survival in patients with nasopharyngeal carcinoma (NPC) with or without oropharyngealcandidiasis (OPC) during radiotherapy. METHODS: The current study was conducted with NPC patients undergoing radiotherapy at Sun Yat-Sen University Cancer Center between June 2011 and May 2012. A clinical diagnosis of candidiasis was determined on the basis of a positive potassium hydroxide (KOH) test and the presence of pseudomembranous (white) form of candidal overgrowth...
2017: PloS One
https://www.readbyqxmd.com/read/28790853/a-systematic-comparison-of-treatment-modalities-for-nasal-extranodal-natural-killer-t-cell-lymphoma-in-early-stages-between-concurrent-chemoradiotherapy-and-sequential-chemotherapy
#18
Ming Qian, Hengmin Tao, Wei Xu, Hongzhi Ji
AIM: Nasal extranodal natural killer/T-cell lymphoma (nasal ENKTL), which is strongly associated with the Epstein-Barr virus infection, is a common disease in Asia and Latin America. We conducted a retrospective study to compare the overall survival (OS) following concurrent or sequential treatment with radiotherapy and chemotherapy in patients with early stage ENKTL. PATIENTS AND METHODS: The records of 58 cases from between 2000 to 2010 were retrieved. Of these, 28 patients (15 males, with median age of 51 years) were treated with sequential chemotherapy followed by radiotherapy (SCRT) and 30 patients (17 males, with median age of 46 years) were treated with concurrent chemoradiotherapy (CCRT)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28780679/locoregional-therapies-for-hepatocellular-carcinoma-and-the-new-li-rads-treatment-response-algorithm
#19
Ania Kielar, Kathryn J Fowler, Sara Lewis, Vahid Yaghmai, Frank H Miller, Hooman Yarmohammadi, Charles Kim, Victoria Chernyak, Takeshi Yokoo, Jeffrey Meyer, Isabel Newton, Richard K Do
Radiologists play a central role in the assessment of patient response to locoregional therapies for hepatocellular carcinoma (HCC). The identification of viable tumor following treatment guides further management and potentially affects transplantation eligibility. Liver Imaging Reporting and Data Systems (LI-RADS) first introduced the concept of LR-treated in 2014, and a new treatment response algorithm is included in the 2017 update to assist radiologists in image interpretation of HCC after locoregional therapy...
August 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28780008/the-role-of-positron-emission-tomography-computed-tomography-imaging-in-head-and-neck-cancer-after-radical-chemoradiotherapy-a-single-institution-experience
#20
C Nelissen, J Sherriff, T Jones, P Guest, S Colley, P Sanghera, A Hartley
AIMS: Positron emission tomography/computed tomography (PET/CT) is used to restage head and neck cancer 3 months after chemoradiotherapy. The purpose of this study was to determine the negative predictive value (NPV) of a scan reported as having no abnormal uptake and the positive predictive values (PPV) for different maximum standardised uptake value (SUVmax) thresholds. MATERIALS AND METHODS: Patients with squamous cell carcinoma of the oro-/hypopharynx/larynx (n = 206) were included...
August 2, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
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