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https://www.readbyqxmd.com/read/28097311/association-of-lymphovascular-space-invasion-with-locoregional-failure-and-survival-in-patients-with-node-negative-oral-tongue-cancers
#1
Richard J Cassidy, Jeffrey M Switchenko, Naresh Jegadeesh, Mutlay Sayan, Matthew J Ferris, Bree R Eaton, Kristin A Higgins, Jeffrey T Wadsworth, Kelly R Magliocca, Nabil F Saba, Jonathan J Beitler
Importance: The indications for adjuvant therapy in resected oral tongue cancers are based on both clinical and pathological factors, with clear evidence for adjuvant radiation in patients with pathologically positive neck lymph nodes, positive margins, and extracapsular extension, but the data for patients with no nodal disease are sparse. Objective: To investigate determinants of failure and survival in patients with node-negative oral tongue cancer. Design, Setting, and Participants: Medical records for patients with oral tongue cancer treated with definitive surgery from 2003 to 2013 were reviewed...
January 12, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28096578/the-effect-of-pregabalin-and-s-ketamine-in-total-knee-arthroplasty-patients-a-randomized-trial
#2
Lajla Kadic, Frank G van Haren, Oliver Wilder-Smith, Jorgen Bruhn, Jacques J Driessen, Maarten C de Waal Malefijt
BACKGROUND AND AIMS: Pain reduction is important for rehabilitation after total knee arthroplasty. Intra- and peri-articular infiltration with local anesthetics may be an alternative to commonly used locoregional techniques. Adding pregabalin orally and s-ketamine intravenously may further reduce postoperative pain. MATERIAL AND METHODS: This prospective, randomized, double-blind, placebo-controlled study compared two methods of perioperative analgesia. Control patients received a standardized multimodal postoperative analgesic regime of paracetamol, diclofenac, and piritramide-patient-controlled analgesia, including ropivacaine knee infiltration during surgery...
October 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28094857/use-of-oncept-melanoma-vaccine-in-69-canine-oral-malignant-melanomas-in-the-uk
#3
S Verganti, D Berlato, L Blackwood, I Amores-Fuster, G A Polton, R Elders, R Doyle, A Taylor, S Murphy
OBJECTIVES: Oral malignant melanomas carry a poor-to-guarded prognosis because of their local invasiveness and high metastatic propensity. The Oncept melanoma vaccine is licensed to treat dogs with stage II or III locally-controlled oral malignant melanoma and this retrospective study aimed to assess survival of affected dogs treated with the vaccine in the UK. MATERIAL AND METHODS: Medical records of dogs with histopathologically-confirmed oral malignant melanoma that received the vaccine as part of their treatment were evaluated...
January 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28094216/mild-to-moderate-dysplasia-at-surgical-margin-is-a-significant-indicator-of-survival-in-patients-with-oral-cancer
#4
Sandhya Gokavarapu, Nagendra Parvataneni, Sreenivasa Pavagada, L M Chandrasekhara Rao, K V Raju, T Subramaneshwar Rao
OBJECTIVE: The objective of this study was to investigate the significance of mild and moderate dysplasia at the surgical margin with regard to survival and locoregional recurrence. STUDY DESIGN: We investigated cases of primary oral squamous cell carcinoma with negative margins retrospectively from the database of a tertiary cancer hospital. All patients had been treated between January 2010 and December 2012, and margin dysplasia was investigated in a multivariate analysis for locoregional recurrence and overall survival...
November 16, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28089483/patterns-of-failure-after-radiotherapy-for-pediatric-patients-with-intracranial-ependymoma
#5
Fatima Tensaouti, Anne Ducassou, Léonor Chaltiel, Stéphanie Bolle, Xavier Muracciole, Bernard Coche-Dequeant, Claire Alapetite, Valérie Bernier, Line Claude, Stéphane Supiot, Aymeri Huchet, Christine Kerr, Elisabeth le Prisé, Anne Laprie
PURPOSE: To investigate the patterns of failure after radiotherapy for pediatric intracranial ependymoma and their correlation with dose parameters. METHODS: Between 2000 and 2013, 206 patients were treated in France. MRI scans at relapse were registered to the original planning CTs for topographic analysis of failure patterns. To compare relapse patients (RP) with non relapse patients (NRP), several dose parameters were derived from dose volume histograms. RESULTS: Over a median follow-up of 53...
January 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28089480/deep-inspiration-breath-hold-produces-a-clinically-meaningful-reduction-in-ipsilateral-lung-dose-during-locoregional-radiation-therapy-for-some-women-with-right-sided-breast-cancer
#6
Jessica L Conway, Leigh Conroy, Lindsay Harper, Marie Scheifele, Haocheng Li, Wendy L Smith, Tannis Graham, Tien Phan, Ivo A Olivotto
PURPOSE: The goal of the work described here was to determine whether deep inspiration breath-hold (DIBH) produces a clinically meaningful reduction in pulmonary dose compared with free breathing (FB) during locoregional radiation for right-sided breast cancer. METHODS AND MATERIALS: Four-field, modified-wide tangent plans with full nodal coverage were developed for 30 consecutive patients on paired DIBH and FB CT scans. Nodes were contoured according to European Society for Radiotherapy and Oncology guidelines...
October 19, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28089208/the-reconstructive-options-for-oropharyngeal-defects-in-the-transoral-robotic-surgery-framework
#7
Giuseppe Meccariello, Filippo Montevecchi, Rossella Sgarzani, Andrea De Vito, Giovanni D'Agostino, Riccardo Gobbi, Chiara Bellini, Claudio Vicini
Transoral robotic surgery (TORS) is a fascinating new technique that has been proved to be a safe and feasible for selected oropharyngeal cancers. Furthermore, TORS offers several advantages in the treatment of locoregionally advanced cancers. Nevertheless, the careful selection of patients is the keypoint for a successful application of this therapeutic modality. However, the reconstruction of large oropharyngeal defects is challenging due to the restoration of velopharyngeal competency and swallowing. Moreover, the absence of mandibular splitting increases the difficulties faced by reconstructive surgeons...
January 11, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28088233/successful-recovery-from-a-subclavicular-ulcer-caused-by-lenvatinib-for-thyroid-cancer-a-case-report
#8
Morimasa Kitamura, Tomomasa Hayashi, Chiaki Suzuki, Shigeru Hirano, Ichiro Tateya, Yo Kishimoto, Koichi Omori
BACKGROUND: There are currently no effective therapeutic methods for locally recurrent, metastatic, or progressive radioactive iodine (RAI)-refractory differentiated thyroid cancer. However, multitargeted tyrosine kinase inhibitors (TKIs) such as lenvatinib or sorafenib have been approved for patients with RAI-refractory differentiated thyroid cancer as a second targeted therapy, and these agents can prolong patient survival. However, several cases have been reported that TKIs have caused fatal complications such as fistula formation or bleeding...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28073986/does-the-addition-of-postoperative-radiotherapy-to-adjuvant-chemotherapy-offer-any-benefit-in-patients-with-non-small-cell-lung-cancer-and-mediastinal-lymphadenopathy
#9
Georgios Koulaxouzidis, Levon Toufektzian, Leanne Ashrafian, Lukacs Veres
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether the addition of postoperative radiotherapy (PORT) to adjuvant chemotherapy offers any benefit in patients undergoing curative resection for non-small cell lung cancer found to harbour mediastinal lymphadenopathy. A total of 77 papers were identified using the reported search, of which 11 represented the best evidence to answer the clinical question. Only studies reporting on survival data of patients receiving adjuvant chemotherapy with and without PORT were included in this analysis...
January 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28071624/comparison-of-two-different-radiation-fractionation-schedules-with-concurrent-chemotherapy-in-head-and-neck-malignancy
#10
M S Alam, R Perween, S A Siddiqui
INTRODUCTION: The worldwide incidence of head and neck malignancy exceeds half a million cases annually. In radiotherapy (RT), conventional fractionation comprises giving five fractions per week from Monday to Friday. Accelerated RT includes administration of six fractions per week is being advocated. It gives better locoregional control and the median overall treatment time is 39 days as compared to 46 days in conventional group. Our study involved comparison of conventional versus accelerated RT with concurrent chemotherapy, in evaluation of local control and toxicity in the two arms...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28069527/liver-transplantation-for-advanced-hepatocellular-carcinoma-after-downstaging-without-up-front-stage-restrictions
#11
William C Chapman, Sandra Garcia-Aroz, Neeta Vachharajani, Kathryn Fowler, Nael Saad, Yiing Lin, Jason Wellen, Benjamin Tan, Adeel S Khan, Majella Doyle
BACKGROUND: The incidence of HCC continues to increase dramatically worldwide. Liver transplantation (LT) is now standard and optimal treatment for patients with HCC in the setting of cirrhosis, but only for tumors within Milan criteria (MC). In patients presenting beyond Milan, locoregional therapy (LRT) may downstage to within-Milan for consideration of LT. While controversial, the current study aims to evaluate the outcomes of LT in patients presenting with advanced stage HCC who underwent downstaging and compare to patients who meet Milan criteria at presentation...
January 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28068239/stereotactic-body-radiation-therapy-for-locally-advanced-pancreatic-cancer-a-systematic-review-and-pooled-analysis-of-19-trials
#12
REVIEW
Fausto Petrelli, Tiziana Comito, Antonio Ghidini, Valter Torri, Marta Scorsetti, Sandro Barni
PURPOSE: Although surgery is the standard of care for resectable pancreatic cancer (PC), standard-dose chemoradiation therapy and chemotherapy alone are suitable for patients with unresectable disease. Stereotactic body radiation therapy (SBRT) is an alternative, focused local therapy that delivers high radiation doses within a few fractions to the cancer, sparing the surrounding critical tissue. We performed a systematic review and pooled analysis of published trials to evaluate the efficacy and safety of this emerging treatment modality...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28068178/cetuximab-plus-chemoradiotherapy-in-immunocompetent-patients-with-anal-carcinoma-a-phase-ii-eastern-cooperative-oncology-group-american-college-of-radiology-imaging-network-cancer-research-group-trial-e3205
#13
Madhur K Garg, Fengmin Zhao, Joseph A Sparano, Joel Palefsky, Richard Whittington, Edith P Mitchell, Mary F Mulcahy, Karin I Armstrong, Nassim H Nabbout, Shalom Kalnicki, Bassel F El-Rayes, Adedayo A Onitilo, Daniel J Moriarty, Thomas J Fitzgerald, Al B Benson
Purpose Squamous cell carcinoma of the anal canal (SCCAC) is characterized by high locoregional failure (LRF) rates after sphincter-preserving definitive chemoradiation (CRT) and is typically associated with anogenital human papilloma virus infection. Because cetuximab enhances the effect of radiation therapy in human papilloma virus-associated oropharyngeal squamous cell carcinoma, we hypothesized that adding cetuximab to CRT would reduce LRF in SCCAC. Methods Sixty-one patients with stage I to III SCCAC received CRT including cisplatin, fluorouracil, and radiation therapy to the primary tumor and regional lymph nodes (45 to 54 Gy) plus eight once-weekly doses of concurrent cetuximab...
January 9, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28064412/journal-of-clinical-monitoring-and-computing-2016-end-of-year-summary-anesthesia
#14
REVIEW
Jan F A Hendrickx, Andre M De Wolf
Clinical monitoring and computing are essential during general anesthesia. As a result it would be impossible to review all the articles published in the Journal of Clinical Monitoring and Computing that are relevant to anesthesia. We therefore will limit this summary to those articles that are uniquely related to anesthesia. The topics include: anesthesia machines; ensuring the airway; anesthetic depth; neuromuscular transmission monitoring; locoregional anesthesia; ultrasound; and pain.
January 7, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28064397/review-and-proposal-of-regional-surgical-management-for-melanoma-revisiting-of-integumentectomy-and-incontinuity-dissection-in-treatment-of-skin-melanoma
#15
Toshihiko Hayashi, Hiroshi Furukawa, Takashi Kitamura, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Taku Maeda, Yuhei Yamamoto
BACKGROUND: Past studies showed that integumentectomy and incontinuity could be effective procedures in the surgical management of melanoma patients. The present study reports on the historical background of these procedures. In addition, we analyze the ICG assisted integumentectomy and incontinuity techniques and algorithms that we had created when performing this procedure. METHOD: In accordance with our algorithm, we performed ICG assisted integumentectomy/incontinuity procedures on 17 patients with stage III melanomas between 2008 and 2016...
January 7, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28064235/outcomes-in-patients-with-pt1-t2-pn0-n1-breast-cancer-after-conservative-surgery-and-whole-breast-radiotherapy
#16
Marianna Trignani, Clelia DI Carlo, Carmen Cefalogli, Marianna Nuzzo, Lucia Anna Ursini, Luciana Caravatta, Francesca Perrotti, Marta DI Nicola, Ambra Pamio, Domenico Genovesi
AIM: To evaluate locoregional recurrence, overall survival, disease-free survival and prognostic influence of the number of positive lymph nodes and other variables in breast cancer treatment. PATIENTS AND METHODS: A total of 377 patients with pT1-T2, pN0-N1 invasive breast carcinoma treated from 2005 to 2013 were retrospectively evaluated. Patients underwent conservative surgery followed by whole-breast radiotherapy. Clavicular region irradiation was not performed...
January 2017: In Vivo
https://www.readbyqxmd.com/read/28064227/pet-probe-guided-surgery-in-patients-with-breast-cancer-proposal-for-a-methodological-approach
#17
Paolo Orsaria, Agostino Chiaravalloti, Alessandro Fiorentini, Chiara Pistolese, Gianluca Vanni, Alessandra Vittoria Granai, Dimitrios Varvaras, Roberta Danieli, Orazio Schillaci, Giuseppe Petrella, Oreste Claudio Buonomo
BACKGROUND: Although it is valuable for detecting distant metastases, identifying recurrence, and evaluating responses to chemotherapy, the role of (18)F-fluorodeoxyglucose positron-emission tomography/computed tomography ((18)F-FDG PET/CT) in assessing locoregional nodal status for initial staging of breast cancer has not yet been well-defined in clinical practice. In the current report, we describe a new PET probe-based clinical approach, with evaluation of the technical performance of a handheld high-energy gamma probe for intraoperative localization of breast carcinomas, and evaluation of lymph node metastases during radio-guided oncological surgery...
January 2017: In Vivo
https://www.readbyqxmd.com/read/28063696/association-of-post-treatment-positron-emission-tomography-with-locoregional-control-and-survival-after-radiation-therapy-for-squamous-cell-carcinoma-of-the-vulva
#18
Yuan James Rao, Comron Hassanzadeh, Anupama Chundury, Caressa Hui, Barry A Siegel, Farrokh Dehdashti, Todd DeWees, Daniel Mullen, Matthew A Powell, David G Mutch, Julie K Schwarz, Perry W Grigsby
BACKGROUND/PURPOSE: The aim of this study was to investigate the use of post-treatment F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for vulvar cancer and compare metabolic response to clinical outcomes. MATERIALS/METHODS: This retrospective study included 21 patients with vulvar squamous cell carcinoma treated with curative-intent radiation between 2007 and 2015. All patients received intensity-modulated radiation treatment (IMRT), a pre-treatment FDG/PET-CT, and a post-treatment FDG-PET/CT performed at a median time of 3months post-IMRT...
January 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28061358/prognostic-factors-of-oral-squamous-cell-carcinoma-in-young-patients-a-systematic-review
#19
REVIEW
Everton Freitas de Morais, Rodrigo Porpino Mafra, Amanda Katarinny Goes Gonzaga, Dyego Leandro Bezerra de Souza, Leão Pereira Pinto, Éricka Janine Dantas da Silveira
PURPOSE: The objective of this review was to identify clinical and pathologic factors related to the prognosis of oral squamous cell carcinoma in young patients. MATERIALS AND METHODS: We conducted a literature search of articles indexed in PubMed (MEDLINE), Scopus, and Science Direct. Prospective and retrospective cohort studies published in English, Portuguese, or Spanish were included. An age threshold of 45 years was established for the purpose of selection...
December 21, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28058553/implications-of-sentinel-lymph-node-drainage-to-multiple-basins-in-head-and-neck-melanoma
#20
Camille L Stewart, Ana Gleisner, Jennifer Kwak, Brandon Chapman, Nathan Pearlman, Csaba Gajdos, Martin McCarter, Nicole Kounalakis
BACKGROUND: Sentinel lymph node biopsy (SLNB) for head and neck melanoma is challenging due to unpredictable drainage. We sought to determine the frequency of drainage to multiple lymphatic basins and asked if this was associated with prognosis in a large, single-center cohort. METHODS: We queried patients diagnosed with head and neck melanomas who had a SLNB performed from January 1998 to April 2016. Demographic and clinical characteristics were compared using Student's t test, Pearson chi-square analysis, log-rank test, Wilcoxon-Mann-Whitney test, and Kaplan-Meier curves...
January 5, 2017: Annals of Surgical Oncology
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