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https://www.readbyqxmd.com/read/28927051/predisposing-factors-for-hepatocellular-carcinoma-recurrence-following-initial-remission-after-transcatheter-arterial-chemoembolization
#1
Akitoshi Douhara, Tadashi Namisaki, Kei Moriya, Mitsuteru Kitade, Kosuke Kaji, Hideto Kawaratani, Kosuke Takeda, Yasushi Okura, Hiroaki Takaya, Ryuichi Noguchi, Norihisa Nishimura, Kenichiro Seki, Shinya Sato, Yasuhiko Sawada, Junichi Yamao, Akira Mitoro, Masakazu Uejima, Tsuyoshi Mashitani, Naotaka Shimozato, Soichiro Saikawa, Keisuke Nakanishi, Masanori Furukawa, Takuya Kubo, Hitoshi Yoshiji
Hepatocellular carcinoma (HCC) is prone to recurrence following curative treatment. The purpose of the present study was to identify the predisposing factors of HCC recurrence following complete remission achieved by transarterial chemoembolization (TACE). A retrospective cohort study of 70 consecutive patients with HCC who underwent TACE as the initial treatment was conducted. The patients were divided into two groups according to their 1-year disease-free survival (DFS) status; the early recurrence group (ER group; n=32), with HCC recurring within 1 year of initial TACE; and the non-early recurrence group (NER group; n=38), who did not experience recurrence within 1 year...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28923700/venous-thromboembolism-risk-in-patients-with-locoregional-urothelial-tract-tumors
#2
Jorge D Ramos, Jonathan T Wingate, Roman Gulati, Elizabeth R Plimack, Lauren C Harshman, Thomas Powles, Simon J Crabb, Guenter Niegisch, Joaquim Bellmunt, Sylvain Ladoire, Ugo De Giorgi, Syed Hussain, Ajjai S Alva, Jack Baniel, Neeraj Agarwal, Jonathan E Rosenberg, Ulka N Vaishampayan, Matthew D Galsky, Evan Y Yu
BACKGROUND: Venous thromboembolism (VTE) is common in cancer patients, but there is limited data on patients with urothelial tract tumors (UTT). We previously identified several associative factors for increased VTE rates in patients with metastatic UTT. In this study, we assessed the frequency, associative factors, and impact on survival of VTE in patients with locoregional UTT. METHODS: Patients with locoregional bladder, upper urinary tract, or urethral cancer were included in this multi-center study from 29 academic institutions...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28923109/the-outcome-of-prostate-cancer-patients-treated-with-curative-intent-strongly-depends-on-survival-after-metastatic-progression
#3
Mariarosa Pascale, Che Ngwa Azinwi, Barbara Marongiu, Gianfranco Pesce, Flavio Stoffel, Enrico Roggero
BACKGROUND: Five-year survival in patients with localized prostate cancer (PCa) is nearly 100%, but metastatic disease still remains incurable. Clinical management of metastatic patients has become increasingly complex as novel therapeutic strategies have emerged. This study aims at evaluating the impact of the first metastatic progression on the outcome of PCa patients treated with curative intent. METHODS: The analysis was conducted using data of 913 cases of localized PCa diagnosed between 2000 and 2014...
September 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28918425/definitive-chemoradiotherapy-for-anal-carcinoma-long-term-results-based-on-consistent-time-to-event-endpoints
#4
Francesca De Felice, Maria Teresa Martinetti, Simone Orelli, Nadia Bulzonetti, Daniela Musio, Vincenzo Tombolini
AIM: To report the long-term results after definitive chemoradiotherapy (CRT) for anal carcinoma, using consistent time-to-event endpoints. METHODS AND MATERIALS: Anal carcinoma patient charts were reviewed. All patients received definitive CRT. Overall survival (OS), local failure-free survival (LFFS), locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), and anal dysfunction-free survival (ADFS) were estimated. RESULTS: In total, 65 patients were included...
September 16, 2017: Oncology
https://www.readbyqxmd.com/read/28914693/care-patterns-and-changes-in-treatment-for-nonmetastatic-breast-cancer-in-2013-2014-versus-2005-a-population-based-high-resolution-study
#5
Marcela Guevara, Rosana Burgui, Jorge Díaz-González, Esteban Salgado, Francisco Vicente, Conchi Moreno-Iribas, María J Urbina, Alicia Córdoba, Concepción de Miguel, Eva Ardanaz
Studies on recent trends in patterns of care for breast cancer patients are scarce. This study aims to examine the patterns and trends in the treatment of women with nonmetastatic breast cancer according to major recommended treatment options. A population-based study was carried out in Navarra, Spain, including all women with a primary invasive nonmetastasized breast cancer, diagnosed in 2005 and in 2013-2014. We compared patients' characteristics and treatment patterns between periods. Factors associated with receipt of recommended treatment were examined by multivariate logistic regression...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28912406/-a-retrospective-study-analyzing-the-clinical-course-of-patients-with-non-small-cell-lung-cancer-receiving-local-or-systemic-therapy-after-post-operative-recurrence
#6
Minehiko Inomata, Hiroaki Tanaka, Kazuki Shimokawa, Kotaro Tokui, Seisuke Okazawa, Chihiro Taka, Kenta Kambara, Shingo Imanishi, Toru Yamada, Toshiro Miwa, Ryuji Hayashi, Shoko Matsui, Tatsuhiko Kashii, Takahiro Homma, Kuninori Nomura, Yoshinori Doki, Kazuyuki Tobe
BACKGROUND: While systemic therapy is one of the therapeutic options available for post-operative recurrence of non-small cell lung cancer, efficacy of local therapy for locoregional recurrence or limited metastatic lesions has also been reported. OBJECTIVE: We aimed to evaluate the clinical course of patients with post-operative recurrence(locoregional or limited metastatic lesion)after receiving local or systemic therapy. METHODS: Clinical data were retrospectively analyzed and survival duration was compared using the logrank test...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28904694/-bellini-duct-carcinoma-a-new-case-study-and-literature-review
#7
Abdessamad El Bahri, Jaouad Chafiki, Nabil Louardi, Omar Jendouzi, Abdellatif Janane, Ahmed Ameur, Mohammed Abbar
Bellini duct carcinoma is a very rare type of renal cell carcinoma (RCC), accounting for less than 1%. It arises from the distal nephron, more specifically from the collecting duct. Its morphological features are extremely variable, making its diagnosis difficult. We report the case of a 62-year old patient admitted with a painless progressive left flank swelling. CT scan showed a huge mass occupying the upper portion of the left kidney. The patient underwent radical nephrectomy. Anatomopathological examination showed collecting duct carcinoma of the kidney...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904686/-rare-and-severe-complication-of-spinal-anesthesia-bacterial-meningitis-about-a-case-and-literature-review
#8
Naoufal Chouaib, Said Jidane, Mostafa Rafai, Ahmed Belkouch, Saad Zidouh, Lahcen Belyamani
Spinal anesthesia (SA) is the first locoregional anesthesia. It can cause side effects and carry risks that need to be avoided, prevented or treated early. We here report the case of a female patient operated under spinal anesthesia who had intense headache associated with nausea and vomiting evolving in the context of fever within a few days after surgeryLumbar puncture showed cloudy liquid revealing Gram + cocci on direct examination. This allowed the diagnosis of bacterial meningitis. Patient's evolution was favorable after antibiotic therapy...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28903550/combination-of-tumor-volume-and-epstein-barr-virus-dna-improved-prognostic-stratification-of-stage-ii-nasopharyngeal-carcinoma-in-the-imrt-era-a-large-scale-cohort-study
#9
Qiu-Yan Chen, Shao-Yan Guo, Lin-Quan Tang, Tong-Yu Lu, Bo-Lin Chen, Qi-Yu Zhong, Meng-Sha Zou, Qing-Nan Tang, Wen-Hui Chen, Shan-Shan Guo, Li-Ting Liu, Yang Li, Ling Guo, Hao-Yuan Mo, Rui Sun, Dong-Hua Luo, Chong Zhao, Ka-Jia Cao, Chao-Nan Qian, Xiang Guo, Mu-Sheng Zeng, Hai-Qiang Mai
Purpose: Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy (IMRT) era. We conducted this cohort study to evaluate the prognostic values of combining these two factors. Materials and Methods: By Kaplan-Meier, we compare the differences of survival curves between 385 patients with different EBV DNA or tumor volume levels, or with the combination of two biomarkers mentioned above...
September 13, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28903460/correction-increased-expression-of-skp2-is-an-independent-predictor-of-locoregional-recurrence-in-cervical-cancer-via-promoting-dna-damage-response-after-irradiation
#10
Hung-Chun Fu, Yi-Chien Yang, Yun-Ju Chen, Hao Lin, Yu-Che Ou, Chan-Chao Chang Chien, Eng-Yen Huang, Hsuan-Ying Huang, Jui Lan, Hsi-Ping Chi, Ko-En Huang, Hong-Yo Kang
[This corrects the article DOI: 10.18632/oncotarget.10057.].
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28903447/locoregionally-recurrent-head-and-neck-squamous-cell-carcinoma-incidence-survival-prognostic-factors-and-treatment-outcomes
#11
Jer-Hwa Chang, Chia-Che Wu, Kevin Sheng-Po Yuan, Alexander T H Wu, Szu-Yuan Wu
PURPOSE: For locoregionally recurrent head and neck squamous cell carcinoma (HNSCC), appropriate therapeutic decisions remain unclear. We examined the treatment outcomes of a national cohort to determine suitable treatments for and prognostic factors in patients with locoregionally recurrent HNSCCs at different stages and sites. PATIENTS AND METHODS: We analyzed data of >20-year-old patients with HNSCC at American Joint Committee on Cancer clinical stages I-IV without metastasis from Taiwan National Health Insurance and cancer registry databases...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900703/utility-of-18-f-fdg-pet-ct-and-cect-in-conjunction-with-serum-ca-19-9-for-detecting-recurrent-pancreatic-adenocarcinoma
#12
Sampanna Rayamajhi, Aparna Balachandran, Mathew Katz, Arun Reddy, Eric Rohren, Priya Bhosale
PURPOSE: The roles of different cross-sectional imaging in evaluating the recurrence of pancreatic adenocarcinoma are not well established. We evaluated the utility of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and contrast-enhanced computed tomography (CECT) in the diagnosis of recurrent pancreatic adenocarcinoma in conjunction with the tumor marker CA 19-9. METHODS: We retrospectively reviewed the records of patients who underwent CECT and FDG PET/CT along with serum CA 19-9 measurement as a follow-up or on a clinical suspicion of recurrent disease after initial surgery for pancreatic adenocarcinoma...
September 12, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28900496/decreased-overall-and-cancer-specific-mortality-with-neoadjuvant-chemotherapy-in-locoregionally-advanced-nasopharyngeal-carcinoma-treated-by-intensity-modulated-radiotherapy-multivariate-competing-risk-analysis
#13
Jian Zhang, Hao Peng, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Li-Zhi Liu, Li Tian, Ying Guo, Ying Sun, Jun Ma
Background: Value of neoadjuvant chemotherapy (NACT) is still controversial in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). Based on competing risk analysis model, we aim at evaluating the efficacy of NACT in decreasing cancer-specific mortality for LA-NPC (except T3-4N0) treated by intensity-modulated radiotherapy (IMRT). Methods: Data on 957 patients with LA-NPC were retrospectively reviewed. The cumulative incidence of cancer-specific and non-cancer-specific (competing) mortality was determined by univariate and multivariate competing risk analysis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28899556/a-multi-institutional-comparison-of-sbrt-and-imrt-for-definitive-reirradiation-of-recurrent-or-second-primary-head-and-neck-cancer
#14
John A Vargo, Matthew C Ward, Jimmy J Caudell, Nadeem Riaz, Neal E Dunlap, Derek Isrow, Sara J Zakem, Joshua Dault, Musaddiq J Awan, Kristin A Higgins, Comron Hassanadeh, Jonathan J Beitler, Chandana A Reddy, Samuel Marcrom, Drexell H Boggs, James A Bonner, Min Yao, Mitchell Machtay, Farzan Siddiqui, Andy M Trotti, Nancy Y Lee, Shlomo A Koyfman, Robert L Ferris, Dwight E Heron
PURPOSE: Two modern methods of reirradiation, intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), are established for patients with recurrent or second primary squamous cell carcinoma of the head and neck (rSCCHN). We performed a retrospective multi-institutional analysis to compare methods. METHODS AND MATERIALS: Data from patients with unresectable rSCCHN previously irradiated to ≥40 Gy who underwent reirradiation with IMRT or SBRT were collected from 8 institutions...
April 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28899226/adenoid-cystic-carcinoma-of-the-head-and-neck-a-retrospective-multicenter-study
#15
Shinji Takebayashi, Shogo Shinohara, Hisanobu Tamaki, Ichiro Tateya, Morimasa Kitamura, Masanobu Mizuta, Shinzo Tanaka, Tsuyoshi Kojima, Ryo Asato, Toshiki Maetani, Koji Ushiro, Yoshiharu Kitani, Kazuyuki Ichimaru, Keigo Honda, Koichiro Yamada, Koichi Omori
BACKGROUND: Adenoid cystic carcinoma of the head and neck (ACCHN) is rare and difficult to study effective treatment at one institute. Our aim is to identify prognostic factors for this disease by conducting a multicenter study at 11 institutions in Japan. METHODS: A retrospective multicenter study of ACCHN was performed. One hundred and three patients were identified between 2006 and 2015. The overall survival (OS) rate for all patients was calculated, and OS, locoregional control (LRC) rate, or no distant metastasis (NDM) rate was calculated for patients in that the surgery was performed without distant metastasis (DM)...
September 12, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28899221/predictors-of-prolongation-in-radiation-treatment-time-in-a-veteran-population-treated-with-chemoradiation-for-oropharyngeal-cancer
#16
Andrew M Vahabzadeh-Hagh, Jean-Claude M Rwigema, Vishad Nabili, Marilene B Wang, William C Lorentz
BACKGROUND: Prolonged radiation treatment time (RTT) is associated with worse tumor control. Here we identify and determine the implications of factors that predict treatment prolongation in Veterans Affairs (VA) patients undergoing chemoradiation. METHODS: Chart review from July 2000 to October 2013. 81 patients with advanced stage oropharyngeal cancer treated with chemoradiation. RESULTS: Twenty-nine patients (35.8%) had RTT prolonged by ≥10 days...
September 12, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28895112/external-validation-of-the-prognostic-nomogram-compass-for-patients-with-peritoneal-carcinomatosis-of-colorectal-cancer
#17
Karel Demey, Albert Wolthuis, Anthony de Buck van Overstraeten, Steffen Fieuws, Vincent Vandecaveye, Eric Van Cutsem, André D'Hoore
BACKGROUND: To optimize outcome, selection of patients for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is critical. Recently, Simkens et al.7 evaluated the peritoneal surface disease severity score (PSDSS) and suggested a new prognostic nomogram, the colorectal peritoneal metastases prognostic surgical score (COMPASS) based on age, peritoneal carcinomatosis index score, locoregional lymph node status, and signet ring cell histology. This COMPASS nomogram had better discriminative ability according to the Harrell c-index than PSDSS (c = 0...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28894817/emerging-insights-into-recurrent-and-metastatic-human-papillomavirus-related-oropharyngeal-squamous-cell-carcinoma
#18
REVIEW
Farhoud Faraji, David W Eisele, Carole Fakhry
OBJECTIVE: To review recent literature on human papillomavirus-related (HPV-positive) oropharyngeal squamous cell carcinoma (OPC) and focus on implications of recurrent and metastatic disease. METHODS: Primary articles from 1990 to 2016 indexed in MEDLINE (1) pertaining to the epidemiology of HPV-positive OPC and (2) providing clinical insight into recurrent and metastatic OPC. RESULTS: The incidence of HPV-positive OPC is increasing globally...
February 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28894793/infiltrative-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-treated-with-a-single-high-dose-y90-radioembolization-and-subsequent-liver-transplantation-without-a-recurrence
#19
Meaghan S Dendy, Juan C Camacho, Johannes M Ludwig, Alyssa M Krasinskas, Stuart J Knechtle, Hyun S Kim
BACKGROUND: Infiltrative hepatocellular carcinoma with macrovascular invasion is a relatively rare presentation and usually fatal disease. METHODS: Both patients exceeded Milan and University of California-San Francisco (UCSF) criteria, and per Barcelona Clinic Liver Cancer group guidelines, they were enrolled in a prospective open-label radioembolization phase II trial that gave them optimized lobar doses of Yttrium-90 as solely the first-line therapy without concomitant or additional pharmacological or locoregional therapies...
September 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28893059/dosimetric-advantages-and-clinical-outcomes-of-simultaneous-integrated-boost-intensity-modulated-radiotherapy-for-anal-squamous-cell-carcinoma
#20
Katsuyuki Sakanaka, Satoshi Itasaka, Yuichi Ishida, Kota Fujii, Takahiro Horimatsu, Takashi Mizowaki, Yoshiharu Sakai, Masahiro Hiraoka
Purpose: The purpose of this study was to explore the dosimetric difference between simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) and three-dimensional conformal radiotherapy (3DCRT), and the clinical outcomes of anal squamous cell carcinoma (ASCC) chemoradiotherapy featuring SIB-IMRT. Materials and Methods: This study included ten patients with ASCC who underwent chemoradiotherapy using SIB-IMRT with 5-fluorouracil and mitomycin C. SIB-IMRT delivered 54 Gy to each primary tumor plus metastatic lymph nodes and 45 Gy to regional lymph nodes, in 30 fractions...
September 15, 2017: Radiation Oncology Journal
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