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https://www.readbyqxmd.com/read/27923035/biomarkers-in-anal-cancer-from-biological-understanding-to-stratified-treatment
#1
Christopher M Jones, Vicky Goh, David Sebag-Montefiore, Duncan C Gilbert
Squamous cell carcinomas of the anus and anal canal represent a model of a cancer and perhaps the first where level 1 evidence supported primary chemoradiotherapy (CRT) in treating locoregional disease with curative intent. The majority of tumours are associated with infection with oncogenic subtypes of human papilloma virus and this plays a significant role in their sensitivity to treatment. However, not all tumours are cured with CRT and there remain opportunities to improve outcomes in terms of oncological control and also reducing late toxicities...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27920629/electrochemotherapy-in-the-treatment-of-massive-multisite-breast-cancer-metastasis-to-the-skin-and-subcutaneous-tissue-a-case-report
#2
Mateusz Wichtowski, Paweł Potocki, Joanna Kufel-Grabowska, Joanna Streb, Dawid Murawa
BACKGROUND: Chest wall recurrence (CWR) from breast cancer after mastectomy is a difficult to treat disease. Electrochemotherapy (ECT) provides a safe, efficient, and non-invasive locoregional treatment approach in this setting. CASE REPORT: A 61-year-old woman presented with unresectable breast cancer recurrence to the skin and subcutaneous tissue for which numerous lines of treatment were unsuccessful. Between February 2015 and May 2015, the patient underwent 3 courses of ECT after which a spectacular regression of the cutaneous metastatic foci was observed...
October 2016: Breast Care
https://www.readbyqxmd.com/read/27920022/adult-ileocolic-intussusception-caused-by-burkitt-lymphoma
#3
Daniele Bernardi, Emanuele Asti, Luigi Bonavina
Ileocolic intussusception due to Burkitt lymphoma is extremely rare in adults. A man aged 17 years presented with a history of recurrent abdominal pain over the past 3 weeks. The abdomen was distended with diffuse tenderness, and bowel sounds were present. Abdominal ultrasound and CT scans showed evidence of small bowel obstruction with marked wall thickening in the ileocecal region and 'target' signs suggestive for intussusception. At laparoscopy, a mass involving the caecum and the terminal ileum was found, along with multiple locoregional nodes, which was highly suggestive of malignancy...
December 5, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27919985/clinical-outcomes-of-definitive-and-postoperative-radiotherapy-for-stage-i-ivb-hypopharyngeal-cancer
#4
Katsuyuki Shirai, Jun-Ichi Saitoh, Atsuhi Musha, Takanori Abe, Daijiro Kobayashi, Yosuke Takakusagi, Yukihiro Takaysu, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano
BACKGROUND: Hypopharyngeal cancer is relatively rare disease and continues to have a poor prognosis. This study analyzed the efficacy and safety of radiotherapy for stage I-IVB hypopharyngeal cancer. PATIENTS AND METHODS: Between 2000 and 2015, 72 patients were treated with definitive radiotherapy and 29 patients with stage IVA were treated with postoperative radiotherapy. RESULTS: With definitive radiotherapy, the 3-year locoregional control rates for stage I-II, III, IVA, and IVB disease were 89%, 74%, 51% and 0%, respectively...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919981/prognostic-factors-in-patients-irradiated-for-recurrent-head-and-neck-cancer
#5
Daniel Seidl, Steven E Schild, Barbara Wollenberg, Samer G Hakim, Dirk Rades
BACKGROUND/AIM: Many patients with recurrent head-and-neck cancer have poor outcomes. Predictive factors allowing judgment of the patient's prognosis are important for treatment individualization. This study aimed to identify such factors after irradiation of locoregional recurrence. PATIENTS AND METHODS: In 60 patients irradiated for locoregionally recurrent head-and-neck cancer, 12 factors were evaluated regarding freedom from second locoregional recurrence and survival, namely gender, tumor site, initial tumor stage, primary treatment, time between cancer diagnosis and irradiation of locoregional recurrence, age, performance score, tumor and nodal category of recurrence, upfront surgery, radiation dose and concurrent chemotherapy...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27918753/axillary-nodal-management-following-neoadjuvant-chemotherapy-a-review
#6
Melissa Pilewskie, Monica Morrow
Importance: The increasing use of neoadjuvant chemotherapy (NAC) for operable breast cancer has raised questions about optimal local therapy for the axilla. Observations: Sentinel lymph node biopsy (SLNB) after NAC in patients presenting with clinically negative nodes has an accuracy similar to upfront SLNB and reduces the need for axillary lymph node dissection compared with SLNB prior to NAC. In patients presenting with node-positive disease, clinical trials demonstrate that SLNB after NAC is accurate when 3 or more sentinel nodes are obtained, but long-term outcomes are lacking...
December 1, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27918720/what-is-the-best-treatment-of-locally-advanced-nasopharyngeal-carcinoma-an-individual-patient-data-network-meta-analysis
#7
Laureen Ribassin-Majed, Sophie Marguet, Anne W M Lee, Wai Tong Ng, Jun Ma, Anthony T C Chan, Pei-Yu Huang, Guopei Zhu, Daniel T T Chua, Yong Chen, Hai-Qiang Mai, Dora L W Kwong, Shie-Lee Cheah, James Moon, Yuk Tung, Kwan-Hwa Chi, George Fountzilas, Jean Bourhis, Jean Pierre Pignon, Pierre Blanchard
Purpose The role of adjuvant chemotherapy (AC) or induction chemotherapy (IC) in the treatment of locally advanced nasopharyngeal carcinoma is controversial. The individual patient data from the Meta-Analysis of Chemotherapy in Nasopharynx Carcinoma database were used to compare all available treatments. Methods All randomized trials of radiotherapy (RT) with or without chemotherapy in nonmetastatic nasopharyngeal carcinoma were considered. Overall, 20 trials and 5,144 patients were included. Treatments were grouped into seven categories: RT alone (RT), IC followed by RT (IC-RT), RT followed by AC (RT-AC), IC followed by RT followed by AC (IC-RT-AC), concomitant chemoradiotherapy (CRT), IC followed by CRT (IC-CRT), and CRT followed by AC (CRT-AC)...
December 5, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27916314/intraoperative-ultrasound-guidance-in-breast-conserving-surgery-shows-superiority-in-oncological-outcome-long-term-cosmetic-and-patient-reported-outcomes-final-outcomes-of-a-randomized-controlled-trial-cobalt
#8
J H Volders, M H Haloua, N M A Krekel, V L Negenborn, R H E Kolk, A M F Lopes Cardozo, A M Bosch, L M de Widt-Levert, H van der Veen, H Rijna, A H M Taets van Amerongen, K Jóźwiak, S Meijer, M P van den Tol
BACKGROUND: The multicenter randomized controlled COBALT trial demonstrated that ultrasound-guided breast-conserving surgery (USS) results in a significant reduction of margin involvement (3.1% vs. 13%) and excision volumes compared to palpation-guided surgery (PGS). The aim of the present study was to determine long term oncological and patient-reported outcomes including quality of life (QoL), together with their progress over time. METHODS: 134 patients with T1-T2 breast cancer were randomized to USS (N = 65) or PGS (N = 69)...
November 23, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27914244/surgical-treatment-and-histopathological-assessment-of-advanced-cervicovaginal-carcinoma-a-prospective-study-and-retrospective-analysis
#9
Michael Höckel, Benjamin Wolf, Bettina Hentschel, Lars-Christian Horn
BACKGROUND: Standard treatment of advanced cervicovaginal cancer [international federation of gynecology and obstetrics (FIGO) stages II(B), III(A, B), IVA] is (chemo-)radiation excluding the possibility of systematic histopathological assessment of locoregional tumour spread. Laterally extended endopelvic resection (LEER) and therapeutic lymph node dissection (tLND) are novel surgical treatment options for advanced cervicovaginal cancer. METHODS: The therapeutic efficacy of LEER for locally advanced primary and recurrent cervicovaginal cancer was reassessed by an update of the prospective observational trial at the University of Leipzig...
November 30, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27913945/the-effect-of-prophylactic-central-neck-dissection-on-locoregional-recurrence-in-papillary-thyroid-cancer-after-total-thyroidectomy-a-systematic-review-and-meta-analysis-pcnd-for-the-locoregional-recurrence-of-papillary-thyroid-cancer
#10
Wenjing Zhao, Lei You, Xianming Hou, Shaobo Chen, Xiaoxia Ren, Ge Chen, Yupei Zhao
BACKGROUND: The use of prophylactic central neck dissection (pCND) for papillary thyroid cancer (PTC) without clinical evidence of nodal metastasis (cN0) remains controversial. This study was designed to examine whether pCND for PTC affected locoregional recurrence (LRR). METHODS: A systematic review was performed to compare the LRR between patients with PTC who underwent total thyroidectomy (TT) and pCND and those who underwent TT alone. The primary outcome was LRR...
December 2, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27913215/influence-of-surveillance-pet-ct-on-detection-of-early-recurrence-after-definitive-radiation-in-stage-iii-non-small-cell-lung-cancer
#11
Jay P Reddy, Chad Tang, Tina Shih, Bumyang Kim, Charissa Kim, Quynh-Nhu Nguyen, James Welsh, Marcelo Benveniste, Jianjun Zhang, Zhongxing Liao, Daniel R Gomez
BACKGROUND: There are few data to support the use of varying imaging modalities in evaluating recurrence in non-small-cell lung cancer (NSCLC). We compared the efficacy of surveillance positron emission tomography (PET)/computed tomography (CT) versus CT scans of the chest in detecting recurrences after definitive radiation for NSCLC. MATERIALS AND METHODS: We retrospectively analyzed 200 patients treated between 2000 and 2011 who met the inclusion criteria of stage III NSCLC, completion of definitive radiation treatment, and absence of recurrence within the initial 6 months...
November 10, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27909957/adaptive-radiation-therapy-in-head-and-neck-cancer-for-clinical-practice-state-of-the-art-and-practical-challenges
#12
REVIEW
Ovidiu Veresezan, Idriss Troussier, Alexis Lacout, Sarah Kreps, Sophie Maillard, Aude Toulemonde, Pierre-Yves Marcy, Florence Huguet, Juliette Thariat
Modern radiation therapy techniques are characterized by high conformality to tumor volumes and steep dose gradients to spare normal organs. These techniques require accurate clinical target volume definitions and rigorous assessment of set up uncertainties using image guidance, a concept called image-guided radiation therapy. Due to alteration of patient anatomy, changes in tissue density/volumes and tumor shrinkage over the course of treatment, treatment accuracy may be challenged. This may result in excessive irradiation of organs at risk/healthy tissues and undercoverage of target volumes with a significant risk of locoregional failure...
December 1, 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27908530/does-para-aortic-irradiation-reduce-the-risk-of-distant-metastasis-in-advanced-cervical-cancer-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#13
Lucas Gomes Sapienza, Maria José Leite Gomes, Vinicius Fernando Calsavara, Mario M Leitao, Glauco Baiocchi
PURPOSE: To evaluate the impact of the extension of the radiotherapy field cranially toward para-aortic lymph nodes (EF-RT) in advanced cervical cancer. MATERIALS AND METHODS: A systematic search of databases (PubMed, CENTRAL, Clinical Trials) was performed and included studies that were published between 1960 and November 2015 without language restrictions. All randomized clinical trials (RCTs) were analyzed further. All patients must have undergone pelvic radiotherapy and the same systemic therapy in both arms...
November 28, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27906044/high-mammographic-breast-density-predicts-locoregional-recurrence-after-modified-radical-mastectomy-for-invasive-breast-cancer-a-case-control-study
#14
Yu-Sen Huang, Jenny Ling-Yu Chen, Chiun-Sheng Huang, Sung-Hsin Kuo, Fu-Shan Jaw, Yao-Hui Tseng, Wei-Chun Ko, Yeun-Chung Chang
BACKGROUND: We aimed to evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcomes in patients with invasive breast cancer after modified radical mastectomy. METHODS: This case-control study included 121 case-control pairs of women diagnosed with invasive breast cancer between 2004 and 2009, and who had undergone modified radical mastectomy and had mammographic breast density measured before or at diagnosis...
December 1, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27905053/seom-clinical-guideline-of-localized-rectal-cancer-2016
#15
E González-Flores, F Losa, C Pericay, E Polo, S Roselló, M J Safont, R Vera, J Aparicio, M T Cano, C Fernández-Martos
Localized rectal adenocarcinoma is a heterogeneous disease and current treatment recommendations are based on a preoperative multidisciplinary evaluation. High-resolution magnetic resonance imaging and endoscopic ultrasound are complementary to do a locoregional accurate staging. Surgery remains the mainstay of treatment and preoperative therapies with chemoradiation (CRT) or short-course radiation (SCRT) must be considered in more locally advanced cases. Novel strategies with induction chemotherapy alone or preceding or after CRT (SCRT) and surgery are in development...
December 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27904861/a-recent-advance-in-image-guided-locoregional-therapy-for-hepatocellular-carcinoma
#16
REVIEW
Yaoping Shi, Bo Zhai
BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Hepatic resection and liver transplantation are considered to be the preferred treatment for HCC. However, as novel therapeutic options such as image-guided locoregional therapies have emerged and been refined, the manner in which HCC is treated has changed dramatically compared with what it was considered just 2 decades earlier. SUMMARY: This study reviews the current results of various image-guided locoregional therapies for treating HCC, especially focusing on thermal ablative and transarterial techniques...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27900445/bridging-locoregional-therapy-prolongs-survival-in-patients-listed-for-liver-transplant-with-hepatocellular-carcinoma
#17
Minzhi Xing, Sonali Sakaria, Renumathy Dhanasekaran, Samir Parekh, James Spivey, Stuart J Knechtle, Di Zhang, Hyun S Kim
BACKGROUND AND AIMS: To evaluate the long-term survival benefit of bridging locoregional therapy (LRT) prior to orthotopic liver transplantation (OLT) in patients with hepatocellular carcinoma (HCC) within Milan criteria. METHODS: Our transplant center registry was studied for all HCC patients within the Milan criteria who were listed for OLT from 1998 to 2013. Baseline clinical characteristics and median overall survival (OS) were calculated and stratified by LRT, OLT status, and wait times...
November 29, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27898196/mucosal-melanoma-of-the-upper-airways-tract-mucosal-melanoma-a-systematic-review-with-meta-analyses-of-treatment
#18
REVIEW
David Jarrom, Vinidh Paleri, Cyrus Kerawala, Thomas Roques, Shreerang Bhide, Laurence Newman, Stuart C Winter
BACKGROUND: Mucosal melanoma of the upper aerodigestive tract (MM-UADT) occurs in a complex anatomic region. It represents a small number of tumors of the head and neck and a small number of melanoma cases. METHODS: Search strategies initially identified 600, 11 of which were included in this study. RESULTS: All studies involved surgery and radiotherapy. None were randomized, and all were assessed as having a high risk of selection and performance bias...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27898195/cost-effectiveness-of-microsurgical-reconstruction-for-head-and-neck-defects-after-oncologic-resection
#19
Lin Lin Gao, Marten Basta, Suhail K Kanchwala, Joseph M Serletti, David W Low, Liza C Wu
BACKGROUND: Microvascular free tissue transfer has become the main technique used for head and neck reconstruction. We assessed the cost-effectiveness of free flap reconstruction for head and neck defects after oncologic resection for squamous cell carcinoma (SCC). METHODS: We developed a Markov model of the cost, quality of life, survival, and incremental cost-effectiveness of reconstruction with free tissue transfer compared with locoregional flaps. Health state probabilities and quality of life scores were determined from literature...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27898192/reappraising-hyalinizing-clear-cell-carcinoma-a-population-based-study-with-molecular-confirmation
#20
Juan C Hernandez-Prera, Ricky Kwan, Joseph Tripodi, Simion Chiosea, Carlos Cordon-Cardo, Vesna Najfeld, Elizabeth G Demicco
BACKGROUND: Hyalinizing clear cell carcinoma (HCCC) is a rare malignancy, characterized by EWSR1-ATF1 gene fusion, whose behavior is poorly understood, as it was for many years considered a diagnosis of exclusion. METHODS: All available salivary gland carcinomas (n = 594) from our institution were reviewed. Diagnosis of HCCC was confirmed by fluorescence in situ hybridization (FISH) for EWSR1. Literature review was performed. RESULTS: We found 15 patients with HCCCs (10 women, 5 men), 13 with EWSR1 rearrangement...
November 29, 2016: Head & Neck
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