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https://www.readbyqxmd.com/read/29350505/bridging-the-digital-divide-mobile-access-to-personal-health-records-among-patients-with-diabetes
#1
Ilana Graetz, Jie Huang, Richard J Brand, John Hsu, Cyrus K Yamin, Mary E Reed
OBJECTIVES: Some patients lack regular computer access and experience a digital divide that causes them to miss internet-based health innovations. The diffusion of smartphones has increased internet access across the socioeconomic spectrum, and increasing the channels through which patients can access their personal health records (PHRs) could help bridge the divide in PHR use. We examined PHR use through a computer-based Web browser or mobile device. STUDY DESIGN: Cross-sectional historical cohort analysis...
January 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29283385/natural-rubber-dendrimer-modified-montmorillonite-nanocomposites-mechanical-and-flame-retardant-properties
#2
Chenyang Zhang, Jincheng Wang
A series of flame-retardant nanocomposites were established based on compounding of natural rubber (NR) and dendrimer modified flame-retardant organic montmorillonite (FR-DOMt). The merits of these nanocomposites were focused on their better mechanical and flame-retardant properties. X-ray diffractometer (XRD) together with scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis revealed that exfoliation, intercalation, or aggregation status in the NRmatrix can be achieved by addition of different amounts of FR-DOMt...
December 28, 2017: Materials
https://www.readbyqxmd.com/read/29261276/mos2-quantum-dots-growth-induced-by-s-vacancy-in-znin2s4-monolayer-atomic-level-heterostructure-for-photocatalytic-hydrogen-production
#3
Shuqu Zhang, Xia Liu, Chengbin Liu, Shenglian Luo, Longlu Wang, Tao Cai, Yunxiong Zeng, Jili Yuan, Wanyue Dong, Yong Pei, Yutang Liu
It is highly demanded to steer the charge flow in photocatalysts for efficient photocatalytic hydrogen reactions (PHRs). In this study, we developed a smart strategy to position MoS2 quantum dots (QDs) at the S vacancies on Zn facet in monolayered ZnIn2S4 (Vs-M-ZnIn2S4) to craft two-dimensional (2D) atomic-level heterostructure (MoS2QDs@Vs-M-ZnIn2S4). The electronic structure calculations indicated that the positive charge density of Zn atom around sulfur-vacancy (Vs) was more intensive than other Zn atoms...
December 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29228003/a-mig-15-jnk-1-map-kinase-cascade-opposes-rpm-1-signaling-in-synapse-formation-and-learning
#4
Oliver Crawley, Andrew C Giles, Muriel Desbois, Sudhanva Kashyap, Rayna Birnbaum, Brock Grill
The Pam/Highwire/RPM-1 (PHR) proteins are conserved intracellular signaling hubs that regulate synapse formation and axon termination. The C. elegans PHR protein, called RPM-1, acts as a ubiquitin ligase to inhibit the DLK-1 and MLK-1 MAP kinase pathways. We have identified several kinases that are likely to form a new MAP kinase pathway that suppresses synapse formation defects, but not axon termination defects, in the mechanosensory neurons of rpm-1 mutants. This pathway includes: MIG-15 (MAP4K), NSY-1 (MAP3K), JKK-1 (MAP2K) and JNK-1 (MAPK)...
December 11, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29225512/development-of-the-multiple-gene-knockout-system-with-one-step-pcr-in-thermoacidophilic-crenarchaeon-sulfolobus-acidocaldarius
#5
Shoji Suzuki, Norio Kurosawa
Multiple gene knockout systems developed in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius are powerful genetic tools. However, plasmid construction typically requires several steps. Alternatively, PCR tailing for high-throughput gene disruption was also developed in S. acidocaldarius, but repeated gene knockout based on PCR tailing has been limited due to lack of a genetic marker system. In this study, we demonstrated efficient homologous recombination frequency (2.8 × 104 ± 6.9 × 103 colonies/μg DNA) by optimizing the transformation conditions...
2017: Archaea: An International Microbiological Journal
https://www.readbyqxmd.com/read/29220051/improving-extraction-and-post-purification-concentration-of-membrane-proteins
#6
Hasin Feroz, HyeYoung Kwon, Jing Peng, Hyeonji Oh, Bryan Ferlez, Carol S Baker, John H Golbeck, Guillermo C Bazan, Andrew L Zydney, Manish Kumar
Membrane proteins (MPs), despite being critically important drug targets for the pharmaceutical industry, are difficult to study due to challenges in obtaining high yields of functional protein. Most current extraction efforts use specialized non-ionic detergents to solubilize and stabilize MPs, with MPs being concentrated by ultrafiltration (UF). However, many detergents are retained during the UF step, which can destabilize MPs and/or interfere with their characterization. Here, we studied the influence of detergent selection on the extraction and UF-based concentration of biomedically-relevant MPs, the light-driven sodium and chloride transporters, KR2 and halorhodopsin (pHR) which are also model proteins for more complex mammalian rhodopsins...
December 8, 2017: Analyst
https://www.readbyqxmd.com/read/29217503/impact-of-an-electronic-health-record-integrated-personal-health-record-on-patient-participation-in-health-care-development-and-randomized-controlled-trial-of-myhealthkeeper
#7
Borim Ryu, Nari Kim, Eunyoung Heo, Sooyoung Yoo, Keehyuck Lee, Hee Hwang, Jeong-Whun Kim, Yoojung Kim, Joongseek Lee, Se Young Jung
BACKGROUND: Personal health record (PHR)-based health care management systems can improve patient engagement and data-driven medical diagnosis in a clinical setting. OBJECTIVE: The purpose of this study was (1) to demonstrate the development of an electronic health record (EHR)-tethered PHR app named MyHealthKeeper, which can retrieve data from a wearable device and deliver these data to a hospital EHR system, and (2) to study the effectiveness of a PHR data-driven clinical intervention with clinical trial results...
December 7, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29210583/time-resolved-infrared-spectroscopy-on-plant-cryptochrome-relevance-of-proton-transfer-and-atp-binding-for-signaling
#8
Lea Schroeder, Sabine Oldemeyer, Tilman Kottke
Plant cryptochromes are light receptors in land plants and algae with very diverse functions such as circadian timing and life cycle progression. The receptor consists of a photolyase homology region (PHR) binding the flavin chromophore and a C-terminal extension (CCT) responsible for signaling. The reputed signaling state, the flavin neutral radical, is formed by a femtosecond electron and microsecond proton transfer to the excited, oxidized flavin. Subsequently, a 500 μs loss of β-sheet structure ~25 Å away from flavin was resolved and suggested to be part of the signal conduction to the CCT...
December 6, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29182535/contextual-exploration-of-a-new-family-caregiver-support-concept-for-geriatric-settings-using-a-participatory-health-research-strategy
#9
Elisabeth Dorant, Theresia Krieger
Family caregivers are the backbone of the long-term care support system within the home environment. Comprehensive caregiver support programs require collaboration and coordination within the system. A new public health concept, Vade Mecum, aims to harmonize and professionalize family caregiver support initiatives in geriatric care settings in the Euregion Maas-Rhine. Exploration of the new concept recently started in Germany to gain in-depth insight into current support and the needs of the geriatric care team and family caregivers...
November 28, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29168251/bendamustine-plus-rituximab-for-indolent-b-cell-lymphoma-of-renal-significance
#10
David Ribes, Hélène E L Hachem, Lucie Oberic, François Vergez, Audrey Delas, Julie Belliere, Caroline Protin, Nassim Kamar, Inès Ferrandiz, Suzanne Tavitian, Camille Laurent, Antoine Huart, Dominique Chauveau, Loïc Ysebaert, Stanislas Faguer
Treatment of indolent B-cell non-Hodgkin lymphomas (iNHL) of renal significance is challenging given the need for deep and prolonged hematological response to restore and control renal function overtime, yet to be balanced with the risk of adverse drug-related events. This prospective single-center study included 20 patients with iNHL of renal significance (tubulointerstitial presentation [n = 8], glomerulopathy with or without monoclonal Ig deposits [n = 12]) who received a steroid-sparing regimen of rituximab plus bendamustine (BR), with either no or <1 month of steroid intake (as a first line therapy in 80%)...
November 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29165359/environmentally-friendly-compatibilizers-from-soybean-oil-for-ternary-blends-of-poly-lactic-acid-pla-poly-%C3%AE%C2%B5-caprolactone-pcl-and-poly-3-hydroxybutyrate-phb
#11
María Jesús Garcia-Campo, Luis Quiles-Carrillo, Jaime Masia, Miguel Jorge Reig-Pérez, Nestor Montanes, Rafael Balart
Ternary blends of poly(lactic acid) (PLA), poly(3-hydroxybutyrate) (PHB) and poly(ε-caprolactone) (PCL) with a constant weight percentage of 60%, 10% and 30% respectively were compatibilized with soybean oil derivatives epoxidized soybean oil (ESO), maleinized soybean oil (MSO) and acrylated epoxidized soybean oil (AESO). The potential compatibilization effects of the soybean oil-derivatives was characterized in terms of mechanical, thermal and thermomechanical properties. The effects on morphology were studied by field emission scanning electron microscopy (FESEM)...
November 22, 2017: Materials
https://www.readbyqxmd.com/read/29159260/public-health-approach-to-prevent-cervical-cancer-in-hiv-infected-women-in-kenya-issues-to-consider-in-the-design-of-prevention-programs
#12
REVIEW
Sonia Menon, Rodolfo Rossi, Stacy G Harmon, Hillary Mabeya, Steven Callens
Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29158845/in-tether-chiral-center-induced-helical-peptide-modulators-target-p53-mdm2-mdmx-and-inhibit-tumor-growth-in-stem-like-cancer-cell
#13
Kuan Hu, Feng Yin, Mengyin Yu, Chengjie Sun, Jingxu Li, Yujie Liang, Wenjun Li, Mingsheng Xie, Yuanzhi Lao, Wei Liang, Zi-Gang Li
Inhibition of the interaction between p53 and MDM2/MDMX has attracted significant attention in anticancer therapy development. We designed a series of in-tether chiral center-induced helical stabilized peptides, among which MeR/PhR effectively reactivated p53. The activation of p53 inhibits cell proliferation and induces apoptosis in both the MCF-7 normal tumor cell line and the PA-1 pluripotent cancer cell line with only minimal cellular toxicity towards normal cells or cancer cell lines with p53 mutations...
2017: Theranostics
https://www.readbyqxmd.com/read/29158650/partial-humeral-replacement-for-peri-prosthetic-fractures-of-the-humerus
#14
Ruben Manohara, Colin R Howie
Introduction: Treating peri-prosthetic fractures of the humerus can be very challenging, especially when there is poor bone stock and in the presence of adjacent joint prostheses. We discuss the option of a partial humeral replacement as a salvage procedure for such cases with some technical comments. Methods: This paper presents a technique which utilises a custom- made cemented connector to incorporate the existing well functioning elbow or shoulder replacement with a commercially available partial humeral replacement (PHR) or to an existing prosthetic humeral stem...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29141839/patient-health-record-systems-scope-and-functionalities-literature-review-and-future-directions
#15
REVIEW
Lina Bouayad, Anna Ialynytchev, Balaji Padmanabhan
BACKGROUND: A new generation of user-centric information systems is emerging in health care as patient health record (PHR) systems. These systems create a platform supporting the new vision of health services that empowers patients and enables patient-provider communication, with the goal of improving health outcomes and reducing costs. This evolution has generated new sets of data and capabilities, providing opportunities and challenges at the user, system, and industry levels. OBJECTIVE: The objective of our study was to assess PHR data types and functionalities through a review of the literature to inform the health care informatics community, and to provide recommendations for PHR design, research, and practice...
November 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29100063/spectrum-of-hpv-types-before-and-after-treatment-of-cervical-intraepithelial-neoplasia-grade-2-and-3
#16
Ylva Lindroth, Kaj Bjelkenkrantz, Ola Forslund
BACKGROUND: To monitor residual disease after treatment of high grade cervical intraepithelial neoplasia (CIN), cytology together with human papillomavirus (HPV) testing are commonly performed. OBJECTIVES: To analyse the spectrum of HPV types before and after treatment. STUDY DESIGN: This register-based study included 446 women treated for CIN2 or 3, where cytology samples had been HPV-tested before and after treatment by the use of the MGP-PCR Luminex HPV L1-DNA-assay identifying 39 HPV types, including 12 high risk (HR) HPV types...
December 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29081012/combining-ontologies-and-open-standards-to-derive-a-middle-layer-information-model-for-interoperability-of-personal-and-electronic-health-records
#17
Panagiotis Plastiras, Dympna M O'Sullivan
The aim of our study was to enable better interoperability between Personal Health Record (PHR) and Electronic Health Record (EHR) systems and vice versa. A multi-layer architectural model that resides between a PHR and EHR system has been developed. The model consists of an ontology-driven information model and a set of transformation rules that work in conjunction to process data exported from a PHR or EHR system and prepare it accordingly for the receiving system. The model was evaluated by executing a set of case study scenarios containing data from both a PHR and an EHR system...
October 28, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29079917/permissive-hypotensive-resuscitation-in-adult-patients-with-traumatic-haemorrhagic-shock-a-systematic-review
#18
REVIEW
Mohammed Albreiki, David Voegeli
BACKGROUND: Permissive hypotensive resuscitation (PHR) is an advancing concept aiming towards deliberative balanced resuscitation whilst treating severely injured patients, and its effectiveness on the survival rate remains unexplored. This detailed systematic review aims to critically evaluate the available literature that investigates the effects of PHR on survival rate. METHODS: A systematic review design searched for comparative and non-comparative studies using EMBASE, MEDLINE, PubMed, Web-of-Science and CENTRAL...
October 27, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29050974/liquefaction-of-ground-tire-rubber-at-low-temperature
#19
Xiangyun Cheng, Pan Song, Xinyu Zhao, Zonglin Peng, Shifeng Wang
Low-temperature liquefaction has been investigated as a novel method for recycling ground tire rubber (GTR) into liquid using an environmentally benign process. The liquefaction was carried out at different temperatures (140, 160 and 180 °C) over variable time ranges (2-24 h) by blending the GTR with aromatic oil in a range from 0 to 100 parts per hundred rubber (phr). The liquefied GTR was separated into sol (the soluble fraction of rubber which can be extracted with toluene) and gel fractions (the solid fraction obtained after extraction) to evaluate the reclaiming efficiency...
October 16, 2017: Waste Management
https://www.readbyqxmd.com/read/29038467/self-sensing-in-bacillus-subtilis-quorum-sensing-systems
#20
Tasneem Bareia, Shaul Pollak, Avigdor Eldar
Bacterial cell-cell signalling, or quorum sensing, is characterized by the secretion and groupwide detection of small diffusible signal molecules called autoinducers. This mechanism allows cells to coordinate their behaviour in a density-dependent manner. A quorum-sensing cell may directly respond to the autoinducers it produces in a cell-autonomous and quorum-independent manner, but the strength of this self-sensing effect and its impact on bacterial physiology are unclear. Here, we explore the existence and impact of self-sensing in the Bacillus subtilis ComQXP and Rap-Phr quorum-sensing systems...
October 16, 2017: Nature Microbiology
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