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https://www.readbyqxmd.com/read/28202428/patient-use-of-electronic-prescription-refill-and-secure-messaging-and-its-association-with-undetectable-hiv-viral-load-a-retrospective-cohort-study
#1
D Keith McInnes, Stephanie L Shimada, Amanda M Midboe, Kim M Nazi, Shibei Zhao, Justina Wu, Casey M Garvey, Thomas K Houston
BACKGROUND: Electronic personal health records (PHRs) can support patient self-management of chronic conditions. Managing human immunodeficiency virus (HIV) viral load, through taking antiretroviral therapy (ART) is crucial to long term survival of persons with HIV. Many persons with HIV have difficulty adhering to their ART over long periods of time. PHRs contribute to chronic disease self-care and may help persons with HIV remain adherent to ART. Proportionally veterans with HIV are among the most active users of the US Department of Veterans Affairs (VA) PHR, called My HealtheVet...
February 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28186028/deriving-a-set-of-privacy-specific-heuristics-for-the-assessment-of-phrs-personal-health-records
#2
Riccardo F Furano, Andre Kushniruk, Jeff Barnett
With the emergence of personal health record (PHR) platforms becoming more widely available, this research focused on the development of privacy heuristics to assess PHRs regarding privacy. Existing sets of heuristics are typically not application specific and do not address patient-centric privacy as a main concern prior to undergoing PHR procurement. A set of privacy specific heuristics were developed based on a scoping review of the literature. An internet-based commercially available, vendor specific PHR application was evaluated using the derived set of privacy specific heuristics...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28186019/designing-personal-health-record-technology-for-shared-decision-making
#3
Selena Davis, Abdul Roudsari, Karen L Courtney
Engaging patients in the self-management decision-making provides opportunities for positive health outcomes. The process of shared decision-making (SDM) is touted as the pinnacle of patient-centred care, yet it has been difficult to implement in practice. Access to tools resulting from the integration of all health data and clinical evidence, and an ease of communications with care providers are needed to engage patients in self management decision-making. Personal health record (PHR) technology is a promising approach for overcoming such barriers...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28177702/modulation-of-mitochondrial-biomarkers-by-intermittent-hypobaric-hypoxia-and-aerobic-exercise-after-eccentric-exercise-in-trained-rats
#4
David Rizo-Roca, Juan Gabriel Ríos-Kristjánsson, Cristian Núñez-Espinosa, Estela Santos-Alves, José Magalhães, António Ascensão, Teresa Pagès, Ginés Viscor, Joan Ramon Torrella
Unaccustomed eccentric contractions induce muscle damage, calcium homeostasis disruption and mitochondrial alterations. Since exercise and hypoxia are known to modulate mitochondrial function, we aimed to analyze the effects on eccentric exercise-induced muscle damage (EEIMD), in trained rats, of two recovery protocols based on: 1) intermittent hypobaric hypoxia (IHH) and 2) IHH followed by exercise. The expression of biomarkers related to mitochondrial biogenesis, dynamics, oxidative stress and bioenergetics was evaluated...
February 2, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28154555/key-impact-of-an-uncommon-plasmid-on-bacillus-amyloliquefaciens-subsp-plantarum-s499-developmental-traits-and-lipopeptide-production
#5
Giulia Molinatto, Laurent Franzil, Sébastien Steels, Gerardo Puopolo, Ilaria Pertot, Marc Ongena
The rhizobacterium Bacillus amyloliquefaciens subsp. plantarum S499 (S499) is particularly efficient in terms of the production of cyclic lipopeptides, which are responsible for the high level of plant disease protection provided by this strain. Sequencing of the S499 genome has highlighted genetic differences and similarities with the closely related rhizobacterium B. amyloliquefaciens subsp. plantarum FZB42 (FZB42). More specifically, a rare 8008 bp plasmid (pS499) harboring a rap-phr cassette constitutes a major distinctive element between S499 and FZB42...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28121135/dielectric-elastomer-generator-with-improved-energy-density-and-conversion-efficiency-based-on-polyurethane-composites
#6
Guoling Yin, Yu Yang, Feilong Song, Christophe Renard, Zhi-Min Dang, Chang-Yong Shi, Dongrui Wang
Dielectric elastomer generators (DEGs), which follow the physics of variable capacitors and harvest electric energy from mechanical work, have attracted intensive attention over the past decade. The lack of ideal dielectric elastomers, after nearly two decades of research, has become the bottleneck for DEGs' practical applications. Here, we fabricated a series of polyurethane-based ternary composites and estimated their potential as DEGs to harvest electric energy for the first time. Thermoplastic polyurethane (PU) with high relative permittivity (∼8) was chosen as the elastic matrix...
February 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28094912/strong-strain-sensing-performance-of-natural-rubber-nanocomposites
#7
Tamil Selvan Natarajan, Subramani Bhagavatheswaran Eshwaran, Klaus Werner Stöckelhuber, Sven Wießner, Petra Pötschke, Gert Heinrich, Amit Das
A detail study concerning the strain (tensile) dependent electrical conductivity of elastomeric composites is reported in this present paper. Multiwall carbon nanotubes (CNT), conducting carbon black (CB), and their combinations were considered as conducting filler in cross-linked natural rubber matrix. The loadings of the fillers were considered from 3 to 11 phr (filler concentration close to their percolation threshold). Without hindering the elastic nature of the composite (reversible stretchability up to several 100%), the change of relative resistance, ΔR/R0 (ΔR is the change in the resistance with respect to strain and R0 is the initial resistance of the sample) of the CB filled composites was found to be as much as ∼1300 at around 120% elongation...
January 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28070215/multiple-hpv-infections-in-female-sex-workers-in-western-kenya-implications-for-prophylactic-vaccines-within-this-sub-population
#8
Sonia Menon, Davy van den Broeck, Rodolfo Rossi, Emilomo Ogbe, Hillary Mabeya
BACKGROUND: Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants that the synergistic effects of potential HR (pHR) and HR HPV genotypes be elucidated to assess the potential impact of prophylactic vaccines. This population in Kenya also harbours a number of other vaginal infections and STIs, including bacterial vaginosis (BV), trichomonas vaginalis (TV) and candida spp...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28063166/cigarette-smoking-is-associated-with-adverse-survival-among-women-with-ovarian-cancer-results-from-a-pooled-analysis-of-19-studies
#9
Camilla Praestegaard, Allan Jensen, Signe M Jensen, Thor S S Nielsen, Penelope M Webb, Christina M Nagle, Anna DeFazio, Estrid Høgdall, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Marc T Goodman, Francesmary Modugno, Kirsten Moysich, Roberta B Ness, Robert Edwards, Keitaro Matsuo, Satoyo Hosono, Ellen L Goode, Stacey J Winham, Brooke L Fridley, Daniel W Cramer, Kathryn L Terry, Joellen M Schildkraut, Andrew Berchuck, Elisa V Bandera, Lisa E Paddock, Leon F Massuger, Nicolas Wentzensen, Paul Pharoah, Honglin Song, Alice Whittemore, Valerie McGuire, Weiva Sieh, Joseph Rothstein, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Alexandra Gentry-Maharaj, Anna H Wu, Celeste L Pearce, Malcolm Pike, Alice W Lee, Rebecca Sutphen, Jenny Chang-Claude, Harvey A Risch, Susanne K Kjaer
Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumours but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer...
January 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28062391/personal-health-records-a-systematic-literature-review
#10
REVIEW
Alex Roehrs, Cristiano André da Costa, Rodrigo da Rosa Righi, Kleinner Silva Farias de Oliveira
BACKGROUND: Information and communication technology (ICT) has transformed the health care field worldwide. One of the main drivers of this change is the electronic health record (EHR). However, there are still open issues and challenges because the EHR usually reflects the partial view of a health care provider without the ability for patients to control or interact with their data. Furthermore, with the growth of mobile and ubiquitous computing, the number of records regarding personal health is increasing exponentially...
January 6, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28059099/biological-relevance-of-human-papillomaviruses-in-vulvar-cancer
#11
Gordana Halec, Laia Alemany, Beatriz Quiros, Omar Clavero, Daniela Höfler, Maria Alejo, Wim Quint, Michael Pawlita, Francesc X Bosch, Silvia de Sanjose
The carcinogenic role of high-risk human papillomavirus (HR-HPV) types in the increasing subset of vulvar intraepithelial neoplasia and vulvar cancer in young women has been established. However, the actual number of vulvar cancer cases attributed to HPV is still imprecisely defined. In an attempt to provide a more precise definition of HPV-driven vulvar cancer, we performed HPV-type-specific E6*I mRNA analyses available for 20 HR-/possible HR (pHR)-HPV types, on tissue samples from 447 cases of vulvar cancer...
January 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28033323/transient-duplication-dependent-divergence-and-horizontal-transfer-underlie-the-evolutionary-dynamics-of-bacterial-cell-cell-signaling
#12
Eran Even-Tov, Shira Omer Bendori, Shaul Pollak, Avigdor Eldar
Evolutionary expansion of signaling pathway families often underlies the evolution of regulatory complexity. Expansion requires the acquisition of a novel homologous pathway and the diversification of pathway specificity. Acquisition can occur either vertically, by duplication, or through horizontal transfer, while divergence of specificity is thought to occur through a promiscuous protein intermediate. The way by which these mechanisms shape the evolution of rapidly diverging signaling families is unclear...
December 2016: PLoS Biology
https://www.readbyqxmd.com/read/28025557/a-study-of-personal-health-record-user-s-behavioral-model-based-on-the-pmt-and-utaut-integrative-perspective
#13
Hui-Lung Hsieh, Yu-Ming Kuo, Shiang-Ru Wang, Bi-Kun Chuang, Chung-Hung Tsai
The personal health record (PHR) is a system that enables borderless medical care services by combining technological innovation and human consideration. This study explored factors affecting the adoption of PHR from technical, medical, and social perspectives according to the Protection Motivation Theory (PMT) and Unified Theory of Acceptance and Use of Technology (UTAUT) model. A survey using a structured questionnaire was subsequently conducted, which produced the following results: (1) The PMT and UTAUT were effective at predicting PHR usage behaviors; (2) Perceived ease-of-use was the most decisive factor influencing the use of PHR, followed by self-efficacy and perceived usefulness; and (3) Behavioral intention for PHR was significantly and positively correlated with usage behavior...
December 23, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28011592/personal-health-records-in-the-netherlands-potential-user-preferences-quantified-by-a-discrete-choice-experiment
#14
Domino Determann, Mattijs S Lambooij, Dorte Gyrd-Hansen, Esther W de Bekker-Grob, Ewout W Steyerberg, Marcel Heldoorn, Line Bjørnskov Pedersen, G Ardine de Wit
OBJECTIVE: To identify groups of potential users based on their preferences for characteristics of personal health records (PHRs) and to estimate potential PHR uptake. METHODS: We performed a discrete choice experiment, which consisted of 12 choice scenarios, each comprising 2 hypothetical PHR alternatives and an opt-out. The alternatives differed based on 5 characteristics. The survey was administered to Internet panel members of the Dutch Federation of Patients and Consumer Organizations...
December 23, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27956062/interaction-between-novel-oscillation-within-the-ventromedial-hypothalamus-and-the-sympathetic-nervous-system
#15
Kamon Iigaya, Shuntaro Okazaki, Yoshino Minoura, Hiroshi Onimaru
The ventromedial hypothalamus (VMH) is known to play an important role in feeding behavior and the control of sympathetic nerve activity (SNA). We report the identification of novel neuron groups that showed oscillations on both sides of the VMH in hypothalamus slice preparations from juvenile rats of postnatal days 5-14. We detected spontaneous rhythmic burst activity with a frequency of around 0.06Hz typically in the dorsolateral region of the VMH (i.e., VMH oscillation) using optical recordings (voltage and calcium imaging), field potential recordings and intracellular membrane potential recordings...
December 10, 2016: Neuroscience
https://www.readbyqxmd.com/read/27938387/impact-of-cushing-s-sign-in-the-prehospital-setting-on-predicting-the-need-for-immediate-neurosurgical-intervention-in-trauma-patients-a-nationwide-retrospective-observational-study
#16
Tetsuya Yumoto, Toshiharu Mitsuhashi, Yasuaki Yamakawa, Atsuyoshi Iida, Nobuyuki Nosaka, Kohei Tsukahara, Hiromichi Naito, Atsunori Nakao
BACKGROUND: Cushing's reflex usually results from intracranial hypertension. Although Cushing's sign can implicate severe traumatic brain injury (TBI) in injured patients, no major investigations have been made. The purpose of this study was to assess the predictability of life-threatening brain injury requiring immediate neurosurgical intervention (LT-BI) among trauma patients with Cushing's sign in the prehospital setting. METHODS: This was a retrospective study using data from the Japan Trauma Data Bank from the period of 2010 to 2014...
December 9, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27925276/conformational-and-intermolecular-interaction-dynamics-of-photolyase-cryptochrome-proteins-monitored-by-the-time-resolved-diffusion-technique
#17
REVIEW
Masato Kondoh, Masahide Terazima
Cryptochrome (CRY), a blue light sensor protein, possesses a similar domain structure to photolyase (PHR) that, upon absorption of light, repairs DNA damage. In this review, we compare the reaction dynamics of these systems by monitoring the reaction kinetics of conformational change and intermolecular interaction change based on time-dependent diffusion coefficient measurements obtained by using the pulsed laser-induced transient grating technique. Using this method, time-dependent biomolecular interactions, such as transient dissociation reactions in solution, have been successfully detected in real time...
December 7, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27915256/the-nihr-public-health-research-programme-intervention-approaches-to-tackle-health-inequalities
#18
H Dorling, L Ollerhead, C Kidgell
BACKGROUND: The National Institute for Health Research (NIHR) Public Health Research (PHR) Programme evaluates interventions intended to improve the health of the public and reduce inequalities in health in the UK. The aim of the research was to establish how projects funded by the PHR Programme between 2009 and 2014 addressed health inequalities. METHODS: A health inequalities intervention framework developed by Bambra et al. was used to map PHR funded studies to a typology...
December 2, 2016: Journal of Public Health
https://www.readbyqxmd.com/read/27891621/animal-cryptochromes-divergent-roles-in-light-perception-circadian-timekeeping-and-beyond
#19
REVIEW
Alicia K Michael, Jennifer L Fribourgh, Russell N Van Gelder, Carrie L Partch
Cryptochromes are evolutionarily related to the light-dependent DNA repair enzyme photolyase, serving as major regulators of circadian rhythms in insects and vertebrate animals. There are two types of cryptochromes in the animal kingdom: Drosophila-like CRYs that act as nonvisual photopigments linking circadian rhythms to the environmental light/dark cycle, and vertebrate-like CRYs that do not appear to sense light directly, but control the generation of circadian rhythms by acting as transcriptional repressors...
November 28, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27884871/simultaneous-liquid-chromatographic-determination-of-ebastine-with-two-sympathomimetic-drugs-using-a-monolithic-column
#20
F Ibrahim, M E K Wahba
Ebastine (EBS) has been assayed in its laboratory-prepared co-formulated tablets with either pseudoephedrine hydrochloride (PSU) or phenylephrine hydrochloride (PHR) using isocratic reversed-phase chromatography. Separation was conducted using a 50 mm × 4.6 mm i.d., Chromolith(®) SpeedROD RP-18 end-capped column at ambient temperature. A mobile phase composed of water:acetonitrile in a ratio of 25:75 having a pH of 3.2, has been utilized at 1 mL/min with UV detection at 254 nm for both EBS and PSU and 274 nm for PHR which in turn increased the sensitivity of the proposed method significantly...
November 24, 2016: Journal of Chromatographic Science
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