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https://www.readbyqxmd.com/read/29777348/the-effect-of-labor-epidural-analgesia-on-maternal-fetal-outcomes-a-retrospective-cohort-study
#1
Qian Wang, Sheng-Xing Zheng, Yu-Fei Ni, Yuan-Yuan Lu, Bing Zhang, Qing-Quan Lian, Ming-Pin Hu
PURPOSE: To evaluate the impact of labor epidural analgesia on maternal-fetal safety outcomes in a signal Chinese academic medical center. METHODS: A single-intervention impact study was conducted at The Second Affiliated Hospital, Wenzhou Medical University. The study period was divided into three phases: (1) baseline phase: from January 1 and June 30, 2009 when no analgesic method was routinely employed during labor; (2) phase-in period: the epidural analgesia was implemented 8 a...
May 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29777040/obe022-an-oral-and-selective-prostaglandin-f2%C3%AE-receptor-antagonist-as-an-effective-and-safe-modality-for-the-treatment-of-preterm-labor
#2
Oliver Pohl, Andre Chollet, Sung Hye Kim, Lucia Riaposova, Francois Spezia, Frederic Gervais, Philippe Guillaume, Philippe Lluel, Murielle Meen, Frederique Lemaux, Vasso Terzidou, Phillip R Bennett, Jean-Pierre Gotteland
Preterm birth is the major challenge in obstetrics affecting ~10% of pregnancies. Pan-prostaglandin synthesis inhibitors (NSAID) prevent preterm labor and prolong pregnancy but raise concerns about fetal renal and cardiovascular safety. We conducted preclinical studies examining the tocolytic effect and fetal safety of the oral prodrug candidate OBE022 and its parent OBE002, both potent and highly selective antagonist of the contractile PGF2α prostaglandin receptor (FP). Efficacy of OBE022 and OBE002, alone and in combination with other tocolytics, was assessed in human tissues and pregnant animal models for inhibition of uterine contraction and delay of parturition...
May 18, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29773486/labor-analgesia-in-czech-republic-and-slovakia-a-2015-national-survey
#3
J Bláha, P Štourač, M Grochová, R Klozová, S Richterová, P Nosková, D Seidlová, V Zenkner, A Novotný, D Schwarz, J Ščamburová, M Kosinová, Ch Kufa, M Kirchnerová, J Macková, L Várošová, R Toboláková, J Cepák, J Firment
BACKGROUND: The purpose of this international survey was to describe the current practices and techniques of labor analgesia in the Czech Republic (CZE) and Slovakia (SVK). METHODS: All Czech and Slovak departments that provide obstetric anesthesia were invited to participate in a one-month (November 2015) prospective study that monitored in detail all peripartum anesthetic procedures delivered by anesthesiologists. Participating centers recorded all data on-line in the CLADE-IS database (Masaryk University, CZE)...
April 7, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29772053/delivery-outcome-after-trial-of-labor-in-nulliparous-women-over-40-years-of-age-a-population-based-study
#4
Victoria Ankarcrona, Daniel Altman, Anna-Karin Wikström, Bo Jacobsson, Sophia Brismar Wendel
INTRODUCTION: An increasing proportion of nulliparous women are over 40 years and labor is more often induced. The aim of this study was to assess delivery outcome in women over 40 years, accounting for the interaction between age and induction. MATERIAL AND METHODS: Population-based study of 1 644 598 nulliparous women with live singleton cephalic term deliveries 1992 to 2011. Risks of intrapartum cesarean section, operative vaginal delivery, obstetric anal sphincter injury (OASIS), and 5-minutes Apgar score <7 were calculated in women ≥40 years with induced or spontaneous labor, and women <40 years with induced labor by unconditional logistic regression, and presented with crude and adjusted odds ratios (aOR) with 95% confidence intervals (95%CI)...
May 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29769482/aetiological-factors-of-female-genitourinary-fistula
#5
F Z Aalpona, M Kamrul-Hasan, F Islam, S Hossain, S Akter, K F Ananya
The purpose of this observational cross-sectional study was to evaluate the histories of women with urinary incontinence caused by genitourinary fistulae in Bangladesh. This is an exploratory analysis to investigate possible contributing factors to the development of urogenital fistulae. Sixty four (64) women who were treated for urogenital fistulae at the National Fistula Center, Dhaka Medical College Hospital, Dhaka, Bangladesh were interviewed from July 2013 to December 2013. Their average age was 35.91 years; majorities were illiterate; had early marriage and came from poor family...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29768964/effects-of-combined-spinal-epidural-analgesia-on-first-stage-of-labor-a-cohort-study
#6
Silvia Poma, Luigia Scudeller, Chiara Verga, Giorgio Mirabile, Barbara Gardella, Federica Broglia, Maria Ciceri, Marinella Fuardo, Simona Pellicori, Maddalena Gerletti, Silvia Zizzi, Elena Masserini, Maria Paola Delmonte, Giorgio Antonio Iotti
BACKGROUND: Neuraxial anesthesia is considered as the gold standard in the control labor of pain. Its variants are epidural analgesia and combined spinal-epidural analgesia. Few studies, as yet, have investigated the duration of labor as a primary outcome. Some authors have suggested that combined spinal-epidural analgesia may reduce labor duration but at the moment the benefit of shortening labor is uncertain. The main aim of this study was to compare combined spinal-epidural with epidural analgesia in terms of their effect on duration of stage I labor, maternal, and neonatal outcomes...
May 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29768579/-cost-effectiveness-analysis-of-spontaneous-vaginal-delivery-and-elective-cesarean-for-normal-risk-pregnant-women-in-the-brazilian-unified-national-health-system
#7
Aline Piovezan Entringer, Márcia Pinto, Marcos Augusto Bastos Dias, Maria Auxiliadora de Souza Mendes Gomes
The purpose of this study was to conduct a cost-effectiveness analysis of spontaneous vaginal delivery and elective cesarean (with no clinical indication) for normal risk pregnant women, from the perspective of the Brazilian Unified National Health System. An analytical decision model was developed and included the choice of delivery mode and clinical consequences for mothers and newborns, from admission for delivery to hospital discharge. The reference population consisted of normal risk pregnant women with singleton, at-term gestations in cephalic position, subdivided into primiparas and multiparas with prior uterine scar...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29767917/puerperae-bonding-with-their-children-and-labor-experiences
#8
Lara Helk Souza, Zaida Aurora Sperli Geraldes Soler, Maria de Lourdes Sperli Geraldes Santos, Natália Sperli Geraldes Marin Dos Santos Sasaki
OBJECTIVES: To analyze the degree of bonding of puerperae with their babies, both in isolation and associated with experiences during and after labor. METHODS: A cross-sectional study carried out among 200 puerperae in São José do Rio Preto, Brazil. To evaluate the mother-child bond, we used the Mother-to-Infant Bonding Scale (MIBS). RESULTS: The mean age of puerperae was 26.4 years; most women were white (60.0%), were married (87.5%), and had an elementary education (51...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29764243/the-cost-of-preterm-labor-and-preterm-birth-for-mothers-with-uncomplicated-pregnancies-and-their-infants-in-italy-a-retrospective-cohort-study
#9
Evie Merinopoulou, Shibani Pokras, Jeanne M Pimenta, Valerio Blini, Chiara Veronesi, Stefano Buda, Luca Degli Esposti, Dimitra Lambrelli
BACKGROUND: Preterm labor (PTL)/preterm birth (PTB) impose significant burden on healthcare systems. Women with uncomplicated pregnancies at risk of PTL/PTB have not been widely investigated, and published evidence on the costs of these women and their infants in Italy is absent. We aimed to describe women with uncomplicated pregnancies and associated costs for these women and their infants. METHODS: Data on women aged 12-44 years with uncomplicated pregnancies who delivered between 1/9/2009-31/12/2014 with PTL diagnosis alone or PTL and PTB, were included from four Italian databases...
May 15, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29763609/cervical-ripening-balloon-with-and-without-oxytocin-in-multiparas-a-randomized-controlled-trial
#10
Alison M Bauer, Justin R Lappen, Kimberly S Gecsi, David N Hackney
BACKGROUND: The optimal method for induction of labor for multiparous women with an unfavorable cervix is unknown. OBJECTIVE: To determine if induction of labor with simultaneous use of oxytocin and a cervical ripening balloon, compared with sequential use, increases the likelihood of delivery within 24 hours in multiparous women. STUDY DESIGN: We performed a randomized controlled trial between November 2014 and June 2017. Eligible participants were multiparous women with a vertex presenting, non-anomalous singleton gestation ≥ 34 weeks undergoing induction of labor...
May 12, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29761674/screening-arab-israeli-pregnant-women-for-group-b-streptococcus-by-the-amplivue-gbs-assay-are-the-rates-higher-than-the-national-average
#11
Marwan Hakim, Adel Jabour, Miriam Anton, Meggie Hakim, Sahar Kheirallah
BACKGROUND: The recommendation of the U.S. Centers for Disease Control and Prevention regarding universal screening for Group B Streptococcus (GBS) at 35-37 weeks gestational age in pregnancy is not accepted in Israel. The National Council for Obstetrics, Neonatology and Genetics recommends intrapartum prophylaxis, mainly based on risk factors, to prevent early neonatal GBS infection. This policy is based on past studies demonstrating low colonization rates of the bacteria in Israeli pregnant women and very low neonatal sepsis rates...
May 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29758096/low-maternal-serum-concentrations-of-mannose-binding-lectin-mbl-are-associated-with-the-risk-of-shorter-duration-of-pregnancy-and-lower-birth-weight
#12
Michal Koucký, Karin Malíčková, Helena Kopřivová, Tereza Cindrová-Davies, Hana Hrbáčková, Andrej Černý, Patrik Šimják, Antonín Pařízek, Tomáš Zima
BACKROUND: Chronic inflammation has been implicated as the underlying mechanism responsible for the pathophysiology of preterm labor. Mannose-bindig lectin (MBL) plays a central role in the innate immune response and is thus an important component of the first line of defense. The aim of this study was to investigate whether serum concentrations of MBL correlated with the incidence of preterm birth and low birth weight in a cohort of women with signs of threatened preterm birth. METHODS: A cohort of 60 patients who presented with regular contractions and/or short cervix (group A) between 24 to 32 weeks of gestation and 20 healthy controls (group B) who had no pregnancy complications and delivered at term were recruited into a prospective study...
May 14, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29757958/hydroxypropyl-%C3%AE-cyclodextrin-for-delivery-of-baicalin-via-inclusion-complexation-by-supercritical-fluid-encapsulation
#13
Ying Li, Zhen-Dan He, Qian-En Zheng, Chengshen Hu, Wing-Fu Lai
Over the years, various methods have been developed to enhance the solubility of insoluble drugs; however, most of these methods are time-consuming and labor intensive or involve the use of toxic materials. A method that can safely and effectively enhance the solubility of insoluble drugs is lacking. This study adopted baicalin as an insoluble drug model, and used hydroxypropyl-β-cyclodextrin for the delivery of baicalin via the inclusion complexation by supercritical fluid encapsulation. Different parameters for the complex preparation as well as the physicochemical properties of the complex have been investigated...
May 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29756422/gestational-age-and-birth-weight-centiles-of-singleton-babies-delivered-normally-following-spontaneous-labor-in-southern-sri-lanka
#14
K Attanayake, S Munasinghe, M Goonewardene, P Widanapathirana, I Sandeepani, L Sanjeewa
Aims: To estimate the gestational age and birth weight centiles of babies delivered normally, without any obstetric intervention, in women with uncomplicated singleton pregnancies establishing spontaneous onset of labour. Method: Consecutive women with uncomplicated singleton pregnancies, attending the Academic Obstetrics and Gynecology Unit of the Teaching Hospital Mahamodara Galle, Sri Lanka, with confirmed dates and establishing spontaneous onset of labor and delivering vaginally between gestational age of 34 - 41 weeks, without any obstetric intervention , during the period September 2013 to February 2014 were studied...
March 31, 2018: Ceylon Medical Journal
https://www.readbyqxmd.com/read/29750952/glucostabilizer%C3%A2-software-guided-insulin-dosing-improves-intrapartum-glycemic-management-in-women-with-diabetes
#15
Cheryl Dinglas, Jolene Muscat, Tracy Adams, Virginia Peragallo-Dittko, Anthony Vintzileos, Hye J Heo
BACKGROUND: During labor, maintenance of maternal euglycemia is critical to decrease the risk of neonatal hypoglycemia and associated morbidities. When continuous intravenous insulin infusion is needed, standardized insulin dosing charts have been used for titration of insulin to maintain glucose in target range. GlucoStabilizer™ is a software-guided insulin dosing system that calculates the dose of intravenous insulin needed based on metabolic parameters, target glucose concentration, and an individual's response to insulin...
May 8, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29749657/fundal-pressure-in-second-stage-of-labor-kristeller-maneuver-is-associated-with-higher-risk-of-levator-ani-muscle-avulsion
#16
Aly Youssef, Ginevra Salsi, Ilaria Cataneo, Giuseppina Pacella, Carlotta Azzarone, Maria Chiara Paganotto, Jovana Krsmanovic, Elisa Montaguti, Luisa Cariello, Federica Bellussi, Nicola Rizzo, Gianluigi Pilu
OBJECTIVE: to investigate the association between fundal pressure in the second stage (Kristeller maneuver) and the risk of levator ani muscle (LAM) injury. METHODS: This was a prospective case-control study conducted in our university hospital. We recruited women immediately following their first vaginal delivery. Women who underwent Kristeller maneuver were recruited as cases. For each case, a control (no Kristeller) was recruited matched by BMI, epidural analgesia, second stage duration and birthweight...
May 10, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29747883/delivery-at-term-when-how-and-why
#17
REVIEW
Kate F Walker, Jim G Thornton
There is growing evidence from randomized trials that induction of labor at or near term does not increase cesarean delivery; observational data show that the optimal gestation for spontaneous delivery for the baby is 39 weeks. Elective cesarean at these gestations is also sometimes considered, but evaluating the associated risks is complex. For the baby, although cesarean obviates the risks of labor, it carries a risk of respiratory problems, which may be severe. For the mother, cesarean is more dangerous than vaginal and emergency cesarean is more dangerous than elective...
June 2018: Clinics in Perinatology
https://www.readbyqxmd.com/read/29747593/companionship-during-facility-based-childbirth-results-from-a-mixed-methods-study-with-recently-delivered-women-and-providers-in-kenya
#18
Patience Afulani, Caroline Kusi, Leah Kirumbi, Dilys Walker
BACKGROUND: Research suggests that birth companionship, and in particular, continuous support during labor and delivery, can improve women's childbirth experience and birth outcomes. Yet, little is known about the extent to which birth companionship is practiced, as well as women and providers' perceptions of it in low-resource settings. This study aimed to assess the prevalence and determinants of birth companionship, and women and providers' perceptions of it in health facilities in a rural County in Western Kenya...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29747591/misoprostol-vaginal-insert-versus-misoprostol-vaginal-tablets-for-the-induction-of-labour-a-cohort-study
#19
Daniele Bolla, Saskia Vanessa Weissleder, Anda-Petronela Radan, Maria Luisa Gasparri, Luigi Raio, Martin Müller, Daniel Surbek
BACKGROUND: Misoprostol vaginal insert for induction of labor has been recently reported to be superior to dinoprostone vaginal insert in a phase III trial, but has never been compared to vaginal misoprostol in another galenic form. The aim of this study was to compare misoprostol vaginal insert (MVI) with misoprostol vaginal tablets (MVT) for induction of labor in term pregnancies. METHODS: In this retrospective cohort study we compared 200 consecutive women induced with 200-μg misoprostol 24-h vaginal insert (Misodel®) with a historical control of 200 women induced with Misoprostol 25-μg vaginal tablets (Cytotec®) every 4-6 h...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29745783/are-non-pregnant-women-afraid-of-childbirth-prevalence-and-predictors-of-fear-of-childbirth-in-students
#20
Lana Žigić Antić, Sandra Nakić Radoš, Nataša Jokić-Begić
INTRODUCTION: Fear of childbirth (FOC) has been mostly studied in peripartum women; however, it can be present in non-pregnant young women, and the question is whether it occurs even before pregnancy planning. OBJECTIVE: (1) to determine the prevalence of clinically significant FOC in non-pregnant female students, and (2) to investigate the role of anxiety sensitivity (AS), trait anxiety, childbirth pain expectancy, and sources of birth knowledge for FOC. METHODS: Non-pregnant female students (N = 374) from different study programmes (health studies, social sciences and humanities, and biotechnical studies) participated in the study...
May 10, 2018: Journal of Psychosomatic Obstetrics and Gynaecology
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