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Irregular skin pigmentation

Ana Paula M Martini, Daiane G Mercurio, Patrícia M B G Maia Campos
BACKGROUND: Cutaneous hyperchromias are disorders of skin pigmentation involving an increase of melanin production and its irregular accumulation in skin cells. It is known that the use of sunscreens helps to prevent changes in the skin pigmentation pattern, but the structural and morphological alterations that occur in the different types of hyperpigmentations need better elucidation. OBJECTIVE: To assess the influence of solar exposure and protection habits on the pattern of skin pigmentation using reflectance confocal microscopy (RCM)...
February 3, 2017: Journal of Cosmetic Dermatology
Kee Suck Suh, Jong Bin Park, Myeong Hyeon Yang, Soo Young Choi, Hyun Hwangbo, Min Soo Jang
Lichen aureus (LA) is a variant of pigmented purpuric dermatosis that is characterized clinically by rust macules, papules or plaques, mainly on the legs. In some cases, LA can be difficult to be distinguished from nummular eczema (NE) with the naked eye. Dermoscopy can be applied to skin lesions, revealing additional features that can be highly valuable for correct diagnosis. This study was conducted to investigate characteristic dermoscopic findings of LA and to identify distinctive features that can differentiate it from NE...
December 3, 2016: Journal of Dermatology
Tova Rogers, Melissa Pulitzer, Maria L Marino, Ashfaq A Marghoob, Oliver Zivanovic, Michael A Marchetti
BACKGROUND: There are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%. It is unclear if these features will aid in the detection of early mucosal melanoma or improve diagnostic accuracy compared to naked-eye examination alone. CASE: An Asian female in her fifties was referred for evaluation of an asymptomatic, irregularly pigmented patch of the clitoral hood and labia minora of unknown duration...
October 2016: Dermatology Practical & Conceptual
M-H Jegou, P Huet, I Penchet
BACKGROUND: Nested melanoma in elderly subjects is an entity that has been reported in the literature only since 2012. In this paper, we describe its distinctive clinical, dermatoscopic and histopathological features and compare them to previous published cases, with the aim of highlighting certain specific criteria of this melanoma subtype. CASE REPORT: A 52-year-old man was referred for the presence on his chest of a large suspicious pigmented lesion of irregular shape and colour...
January 2017: Annales de Dermatologie et de Vénéréologie
Caterina Longo
The aim of the current review is to provide an overview of the use of reflectance confocal microscopy to detect early skin aging signs. This new imaging tool holds the promise to morphologically explore the epidermis and upper dermis at nearly histologic resolution and over time. The main confocal findings of aged skin include the presence of irregular honeycombed pattern, linear skin furrows, mottled pigmentation, and distinct collagen types (coarse and huddled).
October 2016: Dermatologic Clinics
Sang Yub Kim, Sook Jung Yun
Malignant melanoma is a rare disease in Asians but potentially the most aggressive form of skin cancer worldwide. It can occur in any melanocyte-containing anatomic site. Four main cutaneous melanoma subtypes are recognized: lentigo maligna melanoma, superficial spreading melanoma, acral lentiginous melanoma (ALM), and nodular melanoma. Generally, excessive exposure to ultraviolet (UV) radiation increases the risk of melanoma. The exception is ALM, which is the most common melanoma subtype in Asians and is not associated with UV radiation...
September 2016: Chonnam Medical Journal
Leonardo Murgiano, Dominik P Waluk, Rachel Towers, Natalie Wiedemar, Joëlle Dietrich, Vidhya Jagannathan, Michaela Drögemüller, Pierre Balmer, Tom Druet, Arnaud Galichet, M Cecilia Penedo, Eliane J Müller, Petra Roosje, Monika M Welle, Tosso Leeb
We investigated a family of horses exhibiting irregular vertical stripes in their hair coat texture along the neck, back, hindquarters, and upper legs. This phenotype is termed "brindle" by horse breeders. We propose the term "brindle 1 (BR1)" for this specific form of brindle. In some BR1 horses, the stripes were also differentially pigmented. Pedigree analyses were suggestive of a monogenic X-chromosomal semidominant mode of inheritance. Haplotype analyses identified a 5 Mb candidate region on chromosome X...
2016: G3: Genes—Genomes—Genetics
Je-Ho Mun, Jungyoon Ohn, Woo-Il Kim, Sung-Min Park, Moon-Bum Kim
The incidence of melanoma among the Asian population is lower compared to that among the Western European population. These populations differed in their most common histopathologic subtypes, acral lentiginous melanoma being the most common in the Asian population. Although the dermoscopic features of the melanomas on the acral skin have been thoroughly investigated in the Asian population, studies concerning the dermoscopic patterns of melanomas on the non-acral skin have been scarce. The aim of this study was to investigate the dermoscopic patterns of melanomas on the trunk and extremities in the Asian population...
2016: PloS One
Chu-Li Fu, Yun-Feng Hu, Yuan-Zong Song
Idiopathic eruptive macular pigmentation (IEMP) is a rare dermatological disorder with generally unclear etiology and pathogenesis. A 5½-year-old girl was referred to hospital with a 10 month history of brown skin rashes. In early infancy, citrin deficiency had been diagnosed with the SLC25A13 genotype c.851_854del4/c.998G > A, but all clinical and laboratory abnormalities recovered following the introduction of a lactose-free and medium-chain triglyceride-enriched formula. Physical examination at referral indicated symmetric, multiple and non-scaly brown macules on the neck, trunk, buttocks and proximal parts of the extremities...
September 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Richard R Winkelmann, Darrell S Rigel, Laura Ferris, Arthur Sober, Natalie Tucker, Clay J Cockerell
OBJECTIVE: To correlate Multi-spectral Digital Skin Lesion Analysis classifier scores with histopathological severity of pigmented lesions and clinical features of melanoma. DESIGN: Classifier scores were computed for 1,632 skin lesions. Dermatologists evaluated the same lesions for Asymmetry, Border Irregularity, Color variegation, Diameter >6mm, Evolution, Patient's Concern, Regression, and/or "Ugly Duckling" sign. Classifier scores were correlated to the number of clinical risk features and for six histopathological severity levels of pigmented lesions...
March 2016: Journal of Clinical and Aesthetic Dermatology
B Sofen, G Prado, J Emer
Dyschromia is a leading cause for cosmetic consultation, especially in those with diverse skin types (mixture of ethnicities) and with the rise of non-core and untrained physicians performing cosmetic procedures. Melasma and post-inflammatory hyperpigmentation (PIH) account for the majority of cases and are characterized by pigmented macules and patches distributed symmetrically in sun-exposed areas of the forehead, cheeks, and chin in melasma, and irregularly in areas of inflammation or an inciting traumatic event with PIH...
January 2016: Skin Therapy Letter
Eri Ikeda, Akane Goto, Reiko Suzaki, Mizuki Sawada, Itaru Dekio, Sumiko Ishizaki, Mariko Fujibayashi, Hayato Takahashi, Masaru Tanaka
A 43-year-old Japanese man presented with reddish nodules on the ankle. The nodules had a yellowish crust and eroded surface. Dermoscopy revealed red to milky-red globules at the periphery and some glomerular vessels in the center and a whitish-pink network, which corresponded to capillary dilatation in the papillary dermis and prominent acanthosis, respectively. These structures were surrounded by a yellowish peripheral structureless area and multiple white, small, round structures in the center, corresponding to the macerated horny layer and keratin plugs...
April 2016: Dermatology Practical & Conceptual
Engin Sezer, Emel Özturk Durmaz, Emel Çetin, Sedef Şahin
Meyerson phenomenon (MP) is characterized by a symmetrical area of erythema and scales encircling a central lesion, which is most commonly a banal melanocytic nevus. Herein, we describe an unusual case with MP representing an eczematized response to a melanoma in situ and review the literature covering this entity. A 56-year-old man presented with a 6-month history of a pruritic, pigmented lesion on the trunk. The patient had no other significant medical history and no notable family history of similar lesions...
April 2016: Acta Dermatovenerologica Croatica: ADC
Archana Sunil Nikose, Pradnya Mukesh Laddha, Rupal Rajendra Bisen
A 34-year-old female patient presented with a nodular mass near the right lateral canthus since 1 year. The mass was nodular, pigmented with irregular surface and had a very well-defined margins. A wide excisional biopsy was done for the same. Histopathology reported a basal cell carcinoma (BCC) of the skin. BCC is very rare in young females and also the site of occurrence in this case was unusual. The mass was excised with a safety margin of 3 mm to ensure complete removal.
April 2016: International Journal of Applied and Basic Medical Research
Alessandra Napolitano, Raffaella Micillo, Giuseppe Monfrecola
No abstract text is available yet for this article.
August 2016: Experimental Dermatology
Lorenzo Squillace, Milena Cappello, Caterina Longo, Elvira Moscarella, Roberto Alfano, Giuseppe Argenziano
BACKGROUND: Seborrheic keratoses (SKs) may sometimes mimic benign and malignant skin tumors, and a biopsy can be necessary in order to rule out malignancy. METHODS: From the database of our pigmented lesion clinic, we evaluated the dermoscopic features of difficult-to-diagnose SKs that were biopsied between January 2010 and December 2014. RESULTS: SKs represented 3.8% of all excised lesions (161/ 4,182). Specifically, 91 (56.5%) were excised to rule out melanoma, 63 (39...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
J Jaworek-Korjakowska, R Tadeusiewicz
Malignant melanoma, which is the most dangerous type of skin cancer, is commonly diagnosed in all people, regardless of age, gender, or race. In the last several years an increasing melanoma incidence and mortality rate has been observed worldwide. In this research we present a new approach to the detection and classification of border irregularity, one of the major parameter in a widely used diagnostic algorithm ABCD rule of dermoscopy. Accurate assessment of irregular borders is clinically important due to a significantly different occurrence in benign and malignant skin lesions...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Imran Majid, Saher Imran
BACKGROUND: Fractional photothermolysis is one of the most effective treatment options used to resurface scars of different aetiologies. AIM: To assess the efficacy and safety of fractional CO2 laser resurfacing treatment in the management of non-hypertrophic traumatic and burn scars. MATERIALS AND METHODS: Twenty-five patients affected by non-hypertrophic traumatic and burn scars were treated with four sessions of fractional CO2 laser resurfacing treatment at 6-weekly intervals...
July 2015: Journal of Cutaneous and Aesthetic Surgery
Paromita Roy, Sayantani Chakraborty, Sudip Das, Alok Roy
A 75-year-old man presented with a slowly growing mass at the right side of the base of the tongue for 4 months. The mass was painless initially but had become very painful during preceding 4 weeks. On examination a 3 cm diameter, oval swelling was observed at the right side of the base of the tongue. It was firm in consistency, slightly tender, non-ulcerative, and with irregular surface. A deep incisional biopsy was taken from mass under general anesthesia. Histopathology report identified the mass consistent with neurofibroma...
September 2015: Indian Journal of Dermatology
James H Herndon, Elizabeth T Makino, Lily I Jiang, Thomas J Stephens, Rahul C Mehta
BACKGROUND: Photoaged skin is primarily a result of chronic sun exposure. Irregular pigmentation and wrinkling are common clinical manifestations. Monotherapy with retinoids, growth factors, and skin lighteners have proven beneficial. However, long-term treatment with a multi-product facial regimen has not been assessed. OBJECTIVES: This single-center clinical trial was conducted to assess the efficacy and tolerance of a topical multi-product regimen when used by subjects with moderate-to-severe photodamage and hyperpigmentation on the face over a course of 24 weeks...
August 2015: Journal of Clinical and Aesthetic Dermatology
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