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benign prostate hyperplasia

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https://www.readbyqxmd.com/read/28636803/atorvastatin-attenuates-testosterone-induced-benign-prostatic-hyperplasia-in-rats-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-and-cyclo-oxygenase-2
#1
Ismail O Ishola, Habeeb K Tijani, Olufunke O Dosumu, Charles C Anunobi, Tolulope O Oshodi
Diabetes and obesity have been reported to alter sex steroid hormone metabolism. In this study, an attempt was made to investigate the protective effect of atorvastatin (ATR) in combination with celecoxib (CEL) or pioglitazone (PIO) on testosterone-induced BPH in rats. Male Wistar rats (200-250 g) were randomly divided into 9 groups (n=8) and orally treated as follows for 28 consecutive days; Group 1: vehicle (10 ml/kg), group 2: vehicle (10 ml/kg), groups 3 - 5: ATR (0.5, 2.5 and 5 mg/kg, respectively); group 6: CEL (20 mg/kg); Group 7: PIO (20 mg/kg); Groups 8-9: ATR 0...
June 21, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28632688/high-quality-3-dimensional-1h-magnetic-resonance-spectroscopic-imaging-of-the-prostate-without-endorectal-receive-coil-using-a-semi-laser-sequence
#2
Nassim Tayari, Isabell K Steinseifer, Kirsten M Selnæs, Tone F Bathen, Marnix C Maas, Arend Heerschap
OBJECTIVES: Inclusion of 3-dimensional H magnetic resonance spectroscopic imaging (3D-H-MRSI) in routine multiparametric MRI of the prostate requires good quality spectra and easy interpretable metabolite maps of the whole organ obtained without endorectal coil in clinically feasible acquisition times. We evaluated if a semi-LASER pulse sequence with gradient offset independent adiabaticity refocusing pulses (GOIA-sLASER) for volume selection can meet these requirements. MATERIALS AND METHODS: Thirteen patients with suspicion of prostate cancer and 1 patient known to have prostate cancer were examined at 3 T with a multichannel body-receive coil...
June 19, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28632494/long-term-dutasteride-therapy-in-men-with-benign-prostatic-hyperplasia-alters-glucose-and-lipid-profiles-and-increases-severity-of-erectile-dysfunction
#3
Abdulmaged Traish, Karim Sultan Haider, Gheorghe Doros, Ahmad Haider
Background Dutasteride has been successfully used in treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). However, dutasteride inhibits 5α-reductase type 1 and type 2 enzymes and may compromises glucocorticoids and androgen metabolism and alters metabolic function resulting in undesirable metabolic and sexual adverse side effects. Aim The aim of this study was to investigate the long-term adverse effects of dutasteride therapy in men with BPH on: i) blood glucose, ii) glycated hemoglobin (HbA1c), iii) low density lipoprotein-cholesterol (LDL-C); high density lipoprotein-cholesterol (HDL-C) and total cholesterol (TC), iv) testosterone (T), v) liver alanine and aspartate aminotransferases (ALT and AST) and vi) erectile dysfunction (ED)...
June 21, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28631916/-intravesical-prostatic-protrusion-in-diagnosing-infravesical-obstruction-in-men-with-benign-prostatic-hyperplasia
#4
G G Krivoborodov, N S Efremov, A D Bolotov
Infravesical obstruction (IVO) is an important characteristic of the functional state of male lower urinary tract. It is believed that IVO confirmed by pressure-flow study findings warrants switching from a medical to surgical management of lower urinary tract symptoms (LUTS). Intravesical prostatic protrusion (IPP) is a new indicator for detecting IVO secondary to benign prostatic hyperplasia (BPH). This indicator has several advantages over other non-invasive methods for evaluating IVO. The initial findings on the relationship between IPP and IVO suggest the feasibility of its clinical use as a screening tool in men with obstructive voiding symptoms...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28631905/-rationale-of-pharmacotherapy-duration-in-patients-with-benign-prostatic-hyperplasia-a-clinical-morphological-study
#5
M E Sitdykova, D E Tsyplakov, E N Sitdykov, A R Nurtdinov
AIM: To investigate the nature of morphological alterations in the urinary bladder wall in BPH patients receiving pharmacotherapy to establish treatment time limits. MATERIALS AND METHODS: The study comprised 120 BPH patients who underwent a transvesical adenomectomy. Prior to the surgery, 110 patients received pharmacotherapy (-blockers and 5-reductase inhibitors) lasting from 1-6 months to 5-10 years. Preoperative evaluation included a standard diagnostic algorithm...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28631904/-analysis-of-factors-affecting-the-compliance-with-medical-therapy-for-benign-prostatic-hyperplasia
#6
V A Malkhasyan, P I Rasner, A R Gevorkyan, I V Semenyakin, A V Tedeev, D Yu Pushkar
AIM: To investigate factors affecting the compliance of patients with the combination therapy for benign prostatic hyperplasia. MATERIALS AND METHODS: Four hundred BPH outpatients treated with combination therapy were surveyed. RESULTS: The absolute majority of patients (76.16%) expected a quick positive result. 10.47% viewed their disease as too advanced, did not believe in the effectiveness of medical therapy and believed the surgery to be the only treatment option...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28629351/assessing-health-related-quality-of-life-in-urology-a-survey-of-4500-german-urologists
#7
A Schmick, M Juergensen, V Rohde, A Katalinic, A Waldmann
BACKGROUND: Urological diseases and their treatment may negatively influence continence, potency, and health-related quality of life (HRQOL). Although current guidelines recommend HRQOL assessment in clinical urology, specific guidance on how to assess HRQOL is frequently absent. We evaluated whether and how urologists assess HRQOL and how they determine its practicality. METHODS: A random sample of 4500 (from 5200 identified German urologists) was drawn and invited to participate in a postal survey (an initial letter followed by one reminder after six weeks)...
June 19, 2017: BMC Urology
https://www.readbyqxmd.com/read/28628624/heterogeneity-of-mirna-expression-in-localized-prostate-cancer-with-clinicopathological-correlations
#8
Ahmed Hussein Zedan, Søren Garm Blavnsfeldt, Torben Frøstrup Hansen, Boye Schnack Nielsen, Niels Marcussen, Mindaugas Pleckaitis, Palle Jörn Sloth Osther, Flemming Brandt Sørensen
INTRODUCTION: In the last decade microRNAs (miRNAs) have been widely investigated in prostate cancer (PCa) and have shown to be promising biomarkers in diagnostic, prognostic and predictive settings. However, tumor heterogeneity may influence miRNA expression. The aims of this study were to assess the impact of tumor heterogeneity, as demonstrated by a panel of selected miRNAs in PCa, and to correlate miRNA expression with risk profile and patient outcome. MATERIAL AND METHODS: Prostatectomy specimens and matched, preoperative needle biopsies from a retrospective cohort of 49 patients, who underwent curatively intended surgery for localized PCa, were investigated with a panel of 6 miRNAs (miRNA-21, miRNA-34a, miRNA-125b, miRNA-126, miRNA-143, and miRNA-145) using tissue micro-array (TMA) and in situ hybridization (ISH)...
2017: PloS One
https://www.readbyqxmd.com/read/28625956/comparison-of-anti-bph-capsule-herbal-and-terazosin-hcl-in-the-treatment-of-benign-prostate-hyperplasia
#9
Hafiz Mohammad Rashid Nadeem, Ejaz Mohiuddin, Shahab UdDin, Muhammad Daniyal, Khan Usmanghani
Benign prostatic hyperplasia (BPH) is a disease of senile age, usually occurring> 60 years of age. BPH is a disease that involves cell proliferation of the prostate. Pathological hyperplasia affects the elements of the glandular and connective tissue of the prostate. This study is designed to scrutinize the efficacy and tolerability of herbal drug Anti BPH capsule for the management of benign prostate hyperplasia (BPH), in this study we select the 100 patients in which 50 received the Anti BPH capsule and 50 received the Terazosin HCl...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28624553/comparison-of-the-effect-of-naptopidil-and-tamsulosin-on-the-bladder-storage-symptom-with-benign-prostatic-hyperplasia-prospective-multi-institutional-study
#10
Se Yun Kwon, Kyung Seop Lee, Tag Keun Yoo, Jae Il Chung, Ji Youl Lee, Jun Hyuk Hong, Seong Il Seo, Tae Young Jung, Cheol Kwak, Taek Won Kang, Seok-Joong Yun
OBJECTIVE: To compare the efficacies of naftopidil and tamsulosin in terms of reducing storage symptoms in patients with BPH. MATERIAL & METHODS: This prospective randomized study was performed at 10 centers. Ninety-four patients that had been taking tamsulosin for more than 8 weeks, but had an OABSS of greater than 3 points were initially enrolled. After a 1 week washout period, patients were divided into two groups. Forty-five patients were treated with tamsulosin 0...
June 14, 2017: Urology
https://www.readbyqxmd.com/read/28621612/association-of-anril-gene-polymorphisms-with-prostate-cancer-and-benign-prostatic-hyperplasia-in-an-iranian-population
#11
Mohammad Taheri, Farkhondeh Pouresmaeili, Mir Davood Omrani, Mohsen Habibi, Shaghayegh Sarrafzadeh, Rezvan Noroozi, Azadeh Rakhshan, Arezou Sayad, Soudeh Ghafouri-Fard
AIM: Prostate cancer and benign prostate hyperplasia (BPH) are heterogeneous disorders with high prevalence among men. The antisense noncoding RNA in the INK4 locus codes for a long noncoding RNA whose participation in cancer has been elucidated. METHOD: We analyzed rs1333045, rs4977574, rs1333048 and rs10757278 genotypes from this locus in 125 prostate cancer patients, 125 BPH patients as well as 220 normal age-matched subjects by means of tetra-primer amplification refractory mutation system PCR method...
May 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28618700/re-meta-analysis-of-metabolic-syndrome-and-benign-prostatic-hyperplasia-in-chinese-patients
#12
Steven A Kaplan
No abstract text is available yet for this article.
July 2017: Journal of Urology
https://www.readbyqxmd.com/read/28618698/re-greenlight-high-performance-system-hps-120-w-laser-vaporization-versus-transurethral-resection-of-the-prostate-for-the-treatment-of-benign-prostatic-hyperplasia-a-meta-analysis-of-the-published-results-of-randomized-controlled-trials
#13
https://www.readbyqxmd.com/read/28617988/mir-145-detection-in-urinary-extracellular-vesicles-increase-diagnostic-efficiency-of-prostate-cancer-based-on-hydrostatic-filtration-dialysis-method
#14
Yong Xu, Sihua Qin, Taixue An, Yueting Tang, Yiyao Huang, Lei Zheng
BACKGROUND: Extracellular vesicles (EVs) can be detected in body fluids and may serve as disease biomarkers. Increasing evidence suggests that circulating miRNAs in serum and urine may be potential non-invasive biomarkers for prostate cancer (PCa). In the present study, we aimed to investigate whether hydrostatic filtration dialysis (HFD) is suitable for urinary EVs (UEVs) isolation and whether such reported PCa-related miRNAs can be detected in UEVs as PCa biomarkers. METHODS: To analyze EVs miRNAs, we searched for an easy and economic method to enrich EVs from urine samples...
June 15, 2017: Prostate
https://www.readbyqxmd.com/read/28610993/effects-of-a-co-micronized-composite-containing-palmitoylethanolamide-and-polydatin-in-an-experimental-model-of-benign-prostatic-hyperplasia
#15
Marika Cordaro, Daniela Impellizzeri, Rosalba Siracusa, Enrico Gugliandolo, Roberta Fusco, Antonino Inferrera, Emanuela Esposito, Rosanna Di Paola, Salvatore Cuzzocrea
Palmitoylethanolamide (PEA), a fatty acid amide-signaling molecule has well-known anti-inflammatory and neuroprotective effects. Nevertheless, PEA does not possess the ability to prevent free radicals formation. Polydatin (PLD), a biological precursor of resveratrol, has antioxidant activity. A combination of PEA and PLD could, conceivably, have beneficial effects on oxidative stress produced by inflammatory processes. In the present study we investigated the effects of a co-micronized composite containing PEA and PLD (m(PEA/PLD)) in a model of testosterone-induced benign hyperplasia (BPH)...
June 10, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28606274/-evidence-based-evaluation-of-recent-clinical-practice-guidelines-for-the-diagnosis-and-treatment-of-benign-prostatic-hyperplasia
#16
X T Zeng, S Li, K Gong, Z Z Guo, T Z Liu, D L He, X H Wang
Objective: To systematically evaluate the quality of clinical practice guidelines for the diagnosis and treatment of benign prostatic hyperplasia (BPH), and to compare the context of recommendations in order to provide references for clinical application. Methods: We searched databases such as the National Guideline Clearinghouse (NGC), Guidelines International Network (GIN), National Institute for Health and Clinical Excellence (NICE), Scottish Intercollegiate Guidelines Network (SIGN) and World Health Organization (WHO), PubMed, Embase, CNKI, VIP, WanFang Data, CBM, and Medlive from their establishment until August 13, 2016, to collect evidence-based guidelines and/or consensus on BPH...
June 13, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28606273/-the-bladder-function-of-patients-with-benign-prostatic-hyperplasia-should-be-highlighted
#17
B Y Yang, S J Xia
No abstract text is available yet for this article.
June 13, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28604411/metabolic-syndrome-and-voiding-dysfunction
#18
Omar Al Hussein Alawamlh, Bashir Al Hussein Al Awamlh, Richard K Lee
PURPOSE OF REVIEW: The metabolic syndrome (MetS) is an ever growing pandemic consisting of a constellation of abnormalities. Many hypotheses have been put forth to establish a link between this syndrome and voiding dysfunction. We created a layout of the possible, probable, and proven relationships connecting the MetS with voiding dysfunction in men. RECENT FINDINGS: There has been growing interest in the relationship linking MetS and voiding dysfunction, with or without benign prostatic hyperplasia, during the past several years...
June 9, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28601562/patterns-of-benign-prostate-hyperplasia-based-on-magnetic-resonance-imaging-are-correlated-with-lower-urinary-tract-symptoms-and-continence-in-men-undergoing-a-robot-assisted-radical-prostatectomy-for-prostate-cancer
#19
Nikolaos Grivas, Rosanne van der Roest, Corinne Tillier, Daan Schouten, Erik van Muilekom, Ivo Schoots, Henk van der Poel, Stijn Heijmink
OBJECTIVE: To investigate the association between benign prostatic hyperplasia (BPH) patterns, classified by magnetic resonance imaging (MRI), with lower urinary tract symptoms (LUTS) or continence, preoperatively and after robot-assisted laparoscopic radical prostatectomy (RARP). MATERIALS AND METHODS: This retrospective study included 49 prostate cancer patients, with prostate size >47 cm(3), who underwent an endorectal MRI followed by RARP. Five BPH patterns were identified according to Wasserman and additional prostate measurements were recorded...
June 7, 2017: Urology
https://www.readbyqxmd.com/read/28594074/testosterone-and-dihydrotestosterone-levels-in-the-transition-zone-correlate-with-prostate-volume
#20
Tomislav Pejčić, Tomislav Tosti, Živoslav Tešić, Borivoj Milković, Dejan Dragičević, Milutin Kozomara, Milica Čekerevac, Zoran Džamić
BACKGROUND: There is still no consensus regarding intraprostatic androgen levels and the accumulation of androgens in the hyperplastic prostatic tissue. The current opinion is that intraprostatic dihydrotestosterone (DHT) concentrations are maintained but not elevated in benign prostatic hyperplasia (BPH), while there is no similar data concerning intraprostatic testosterone (T). METHODS: Tissue T (tT) and tissue DHT (tDHT) concentration were determined in 93 patients scheduled for initial prostate biopsy...
June 8, 2017: Prostate
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