keyword
https://read.qxmd.com/read/38536448/arterial-spin-labelling-magnetic-resonance-imaging-and-perfusion-patterns-in-neurocognitive-and-other-mental-disorders-a-systematic-review
#1
REVIEW
Rita Ferreira, António J Bastos-Leite
We reviewed 33 original research studies assessing brain perfusion, using consensus guidelines from a "white paper" issued by the International Society for Magnetic Resonance in Medicine Perfusion Study Group and the European Cooperation in Science and Technology Action BM1103 ("Arterial Spin Labelling Initiative in Dementia"; https://www.cost.eu/actions/BM1103/ ). The studies were published between 2011 and 2023 and included participants with subjective cognitive decline plus; neurocognitive disorders, including mild cognitive impairment (MCI), Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), dementia with Lewy bodies (DLB) and vascular cognitive impairment (VCI); as well as schizophrenia spectrum disorders, bipolar and major depressive disorders, autism spectrum disorder, attention-deficit/hyperactivity disorder, panic disorder and alcohol use disorder...
March 27, 2024: Neuroradiology
https://read.qxmd.com/read/38536031/stimulating-the-cingulate-to-move
#2
JOURNAL ARTICLE
An Qi Xu, Nicolas Nguyen, Elie Bou Assi, Dang Khoa Nguyen
No abstract text is available yet for this article.
March 27, 2024: Epileptic Disorders: International Epilepsy Journal with Videotape
https://read.qxmd.com/read/38534988/structural-brain-connectivity-and-treatment-improvement-in-mood-disorder
#3
JOURNAL ARTICLE
Sébastien Dam, Jean-Marie Batail, Gabriel Hadrien Robert, Dominique Drapier, Pierre Maurel, Julie Coloigner
BACKGROUND: The treatment of depressive episodes is well established, with clearly demonstrated effectiveness of antidepressants and psychotherapies. However, more than one-third of depressed patients do not respond to treatment. Identifying the brain structural basis of treatment-resistant depression could prevent useless pharmacological prescriptions, adverse events, and lost therapeutic opportunities. METHODS: Using diffusion magnetic resonance imaging, we performed structural connectivity analyses on a cohort of 154 patients with mood disorder (MD) - and 77 sex- and age-matched healthy control (HC) participants...
March 27, 2024: Brain Connectivity
https://read.qxmd.com/read/38533665/introducing-the-concept-of-sanctuary-sites-in-ischemic-stroke
#4
JOURNAL ARTICLE
Tharani Thirugnanachandran, Henry Ma, Geoffrey A Donnan, David C Reutens, Thanh G Phan
BACKGROUND: The topography of arterial territories has been defined using digital maps of supratentorial infarcts. Regions with a high probability of infarction (Pi) exist in the deep compartment due to a paucity of collaterals. However, less attention has been given to regions with a low Pi. METHODS: Using published digital maps, patients with cortical stroke and documented vessel occlusion were included. Infarcts from T2 -weighted magnetic resonance images were segmented and registered onto a standard brain template (Montreal Neurological Institute 152)...
March 27, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38533447/research-on-adults-with-subthreshold-depression-after-aerobic-exercise-a-resting-state-fmri-study-based-on-regional-homogeneity-reho
#5
JOURNAL ARTICLE
Wenbin Shen, Xiaoxiao Wang, Qin Li, Qingguo Ding, Hongqiang Zhang, Zheng Qian, Zhixin Sun, Xingyu Chen, Jun Zhang, Mengqi Zhao, Lina Huang, Wei Xing
OBJECTIVE: Subthreshold depression (StD)/subsyndromal depression refers to a threatening precursor to depression. Aerobic exercise is a promising self-supportive adjunctive intervention and an effective measure for StD. Our study utilizes regional homogeneity (ReHo) to investigate the impact of aerobic exercise on resting-state brain function. METHODS: A total of 78 subjects, aged between 18 and 48 years, (StD group, n = 44; healthy control (HC) group, n = 34) engaged in moderate-intensity aerobic exercise 3-4 times per week for 8 weeks...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38532009/chronometric-tms-fmri-of-personalized-left-dorsolateral-prefrontal-target-reveals-state-dependency-of-subgenual-anterior-cingulate-cortex-effects
#6
JOURNAL ARTICLE
Sarah Grosshagauer, Michael Woletz, Maria Vasileiadi, David Linhardt, Lena Nohava, Anna-Lisa Schuler, Christian Windischberger, Nolan Williams, Martin Tik
Transcranial magnetic stimulation (TMS) applied to a left dorsolateral prefrontal cortex (DLPFC) area with a specific connectivity profile to the subgenual anterior cingulate cortex (sgACC) has emerged as a highly effective non-invasive treatment option for depression. However, antidepressant outcomes demonstrate significant variability among therapy plans and individuals. One overlooked contributing factor is the individual brain state at the time of treatment. In this study we used interleaved TMS-fMRI to investigate the influence of brain state on acute TMS effects, both locally and remotely...
March 26, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38531174/effect-of-increasing-cognitive-activity-participation-on-default-mode-network-in-older-adults-with-subjective-cognitive-decline-a-randomised-controlled-trial
#7
JOURNAL ARTICLE
Allen Ting Chun Lee, Yishan Luo, Zhaohua Huo, Lin Shi, Winnie Chiu Wing Chu, Linda Chiu Wa Lam
BACKGROUND: Having more cognitive activities may prevent dementia, but its evidence of modulating the functional brain network is limited. This randomised controlled trial (RCT) investigated the effect of increased cognitive activity participation on the default mode network (DMN) in older adults who had already been having regular cognitive activity participation and experiencing subjective cognitive decline (SCD). METHODS: Community-living Chinese individuals aged 55-75 years with regular practice of Chinese calligraphy and screened positive for SCD (but negative for mild cognitive impairment or dementia) were randomly allocated to either the intervention or control group...
March 25, 2024: EBioMedicine
https://read.qxmd.com/read/38530121/gray-matter-volume-associations-in-youth-with-adhd-features-of-inattention-and-hyperactivity-impulsivity
#8
JOURNAL ARTICLE
Gabrielle E Reimann, Hee Jung Jeong, E Leighton Durham, Camille Archer, Tyler M Moore, Fanual Berhe, Randolph M Dupont, Antonia N Kaczkurkin
BACKGROUND: Prior research has shown smaller cortical and subcortical gray matter volumes among individuals with attention-deficit/hyperactivity disorder (ADHD). However, neuroimaging studies often do not differentiate between inattention and hyperactivity/impulsivity, which are distinct core features of ADHD. The present study uses an approach to disentangle overlapping variance to examine the neurostructural heterogeneity of inattention and hyperactivity/impulsivity dimensions. METHODS: We analyzed data from 10,692 9- to 10-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38529533/morphometric-similarity-differences-in-drug-naive-parkinson-s-disease-correlate-with-transcriptomic-signatures
#9
JOURNAL ARTICLE
Yajie Wang, Yiwen Xiao, Yi Xing, Miao Yu, Xiao Wang, Jingru Ren, Weiguo Liu, Yuan Zhong
BACKGROUND: Differences in cortical morphology have been reported in individuals with Parkinson's disease (PD). However, the pathophysiological mechanism of transcriptomic vulnerability in local brain regions remains unclear. OBJECTIVE: This study aimed to characterize the morphometric changes of brain regions in early drug-naive PD patients and uncover the brain-wide gene expression correlates. METHODS: The morphometric similarity (MS) network analysis was used to quantify the interregional structural similarity from multiple magnetic resonance imaging anatomical indices measured in each brain region of 170 early drug-naive PD patients and 123 controls...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38529485/cingulate-cortex-shapes-early-postnatal-development-of-social-vocalizations
#10
Gurueswar Nagarajan, Denis Matrov, Anna C Pearson, Cecil Yen, Sean P Bradley, Yogita Chudasama
The social dynamics of vocal behavior has major implications for social development in humans. We asked whether early life damage to the anterior cingulate cortex (ACC), which is closely associated with socioemotional regulation more broadly, impacts the normal development of vocal expression. The common marmoset provides a unique opportunity to study the developmental trajectory of vocal behavior, and to track the consequences of early brain damage on aspects of social vocalizations. We created ACC lesions in neonatal marmosets and compared their pattern of vocalization to that of age-matched controls throughout the first 6 weeks of life...
February 21, 2024: bioRxiv
https://read.qxmd.com/read/38529477/cingulotomy-the-last-man-standing-in-the-battle-against-medically-refractory-poststroke-pain
#11
Linda Kollenburg, Erkan Kurt, Hisse Arnts, Saman Vinke
INTRODUCTION: Central poststroke pain (CPSP) places a huge burden on patient lives because patients are often refractory to conventional strategies and have little chance for spontaneous recovery. A subset of patients is even given approval for euthanasia and is without any perspective. Because the anterior cingulate cortex historically seems to be a promising target for patients with both mental and chronic pain disorders, lesioning of this central "hub" with cingulotomy may be a useful strategy for medically refractory CPSP...
April 2024: Pain Reports
https://read.qxmd.com/read/38528368/where-alcohol-use-disorder-meets-interoception-a-meta-analytic-view-on-structural-and-functional-neuroimaging-data
#12
JOURNAL ARTICLE
Markus Muehlhan, Carolin Spindler, Sandra Nowaczynski, Claudius Buchner, Maximilian Fascher, Sebastian Trautmann
Alcohol use disorder (AUD) has been associated with changes in the processing of internal body signals, known as interoception. Changes in brain structure, particularly in the insula, are thought to underlie impaired interoception. As studies specifically investigating this association are largely lacking, this analysis takes an approach that compares meta-analytic results on interoception with recently published meta-analytic results on gray matter reduction in AUD. A systematic literature search identified 25 eligible interoception studies...
March 25, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38527658/on-the-interplay-between-state-dependent-reconfigurations-of-global-signal-correlation-and-bold-fluctuations-an-fmri-study
#13
JOURNAL ARTICLE
Stefano Damiani, Paolo La-Torraca-Vittori, Livio Tarchi, Eleonora Tosi, Valdo Ricca, Andrea Scalabrini, Pierluigi Politi, Paolo Fusar-Poli
BACKGROUND: The dynamics of global, state-dependent reconfigurations in brain connectivity are yet unclear. We aimed at assessing reconfigurations of the global signal correlation coefficient (GSCORR), a measure of the connectivity between each voxel timeseries and the global signal, from resting-state to a stop-signal task. The secondary aim was to assess the relationship between GSCORR and blood-oxygen-level-dependent (BOLD) activations or deactivation across three different trial-conditions (GO, STOP-correct, and STOP-incorrect)...
March 23, 2024: NeuroImage
https://read.qxmd.com/read/38527192/subcallosal-cingulate-deep-brain-stimulation-evokes-two-distinct-cortical-responses-via-differential-white-matter-activation
#14
JOURNAL ARTICLE
Andreas Seas, M Sohail Noor, Ki Sueng Choi, Ashan Veerakumar, Mosadoluwa Obatusin, Jacob Dahill-Fuchel, Vineet Tiruvadi, Elisa Xu, Patricio Riva-Posse, Christopher J Rozell, Helen S Mayberg, Cameron C McIntyre, Allison C Waters, Bryan Howell
Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for refractory depression. Good clinical outcomes are associated with the activation of white matter adjacent to the SCC. This activation produces a signature cortical evoked potential (EP), but it is unclear which of the many pathways in the vicinity of SCC is responsible for driving this response. Individualized biophysical models were built to achieve selective engagement of two target bundles: either the forceps minor (FM) or cingulum bundle (CB)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38526956/functional-connectivity-between-the-habenula-and-posterior-default-mode-network-contributes-to-the-response-of-the-duloxetine-effect-in-major-depressive-disorder
#15
JOURNAL ARTICLE
Yanru Wu, Zhaosong Chu, Xianyu Chen, Yun Zhu, Xiufeng Xu, Zonglin Shen
This study aims to investigate the functional connectivity (FC) changes of the habenula (Hb) among patients with major depressive disorder (MDD) after 12 weeks of duloxetine treatment (MDD12). Patients who were diagnosed with MDD for the first time and were drug-naïve were recruited at baseline as cases. Healthy controls (HCs) matched for sex, age, and education level were also recruited at the same time. At baseline, all participants underwent resting-state functional MRI. FC analyses were performed using the Hb seed region of interest, and three groups including HCs, MDD group and MDD12 group were compared using whole-brain voxel-wise comparisons...
March 4, 2024: Neuroreport
https://read.qxmd.com/read/38524115/age-related-differences-in-affective-behaviors-in-mice-possible-role-of-prefrontal-cortical-hippocampal-functional-connectivity-and-metabolomic-profiles
#16
JOURNAL ARTICLE
Marcelo Febo, Rohit Mahar, Nicholas A Rodriguez, Joy Buraima, Marjory Pompilus, Aeja M Pinto, Matteo M Grudny, Adriaan W Bruijnzeel, Matthew E Merritt
INTRODUCTION: The differential expression of emotional reactivity from early to late adulthood may involve maturation of prefrontal cortical responses to negative valence stimuli. In mice, age-related changes in affective behaviors have been reported, but the functional neural circuitry warrants further investigation. METHODS: We assessed age variations in affective behaviors and functional connectivity in male and female C57BL6/J mice. Mice aged 10, 30 and 60 weeks (wo) were tested over 8 weeks for open field activity, sucrose preference, social interactions, fear conditioning, and functional neuroimaging...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38522143/effects-of-paternal-deprivation-on-empathetic-behavior-and-the-involvement-of-oxytocin-receptors-in-the-anterior-cingulate-cortex
#17
JOURNAL ARTICLE
Wenjuan Hou, Huan Ma, Caihong Huang, Yin Li, Lu Li, Lizi Zhang, Yishan Qu, Yufeng Xun, Qixuan Yang, Zhixiong He, Fadao Tai
Paternal deprivation (PD) impairs social cognition and sociality and increases levels of anxiety-like behavior. However, whether PD affects the levels of empathy in offspring and its underlying mechanisms remain unknown. The present study found that PD increased anxiety-like behavior in mandarin voles (Microtus mandarinus), impaired sociality, reduced the ability of emotional contagion, and the level of consolation behavior. Meanwhile, PD reduced OT neurons in the paraventricular nucleus (PVN) in both male and female mandarin voles...
March 23, 2024: Hormones and Behavior
https://read.qxmd.com/read/38522078/impaired-neuronal-macroautophagy-in-the-prelimbic-cortex-contributes-to-comorbid-anxiety-like-behaviors-in-rats-with-chronic-neuropathic-pain
#18
JOURNAL ARTICLE
Su Fu, Haojie Sun, Jiaxin Wang, Shuaixin Gao, Liu Zhu, Kun Cui, Shimeng Liu, Xuetao Qi, Rui Guan, Xiaocen Fan, Qingying Liu, Wen Chen, Li Su, Shuang Cui, Feifei Liao, Fengyu Liu, Catherine C L Wong, Ming Yi, You Wan
A large proportion of patients with chronic pain experience co-morbid anxiety. The medial prefrontal cortex (mPFC) is proposed to underlie this comorbidity, but the molecular and neuronal mechanisms are not fully understood. Here, we reported that impaired neuronal macroautophagy in the prelimbic cortical (PrL) subregion of the mPFC paralleled the occurrence of anxiety-like behaviors in rats with chronic spared nerve injury (SNI). Intriguingly, such macroautophagy impairment was mainly observed in a FOS/c-Fos+ neuronal subpopulation in the PrL...
March 24, 2024: Autophagy
https://read.qxmd.com/read/38521994/fragile-x-cortex-is-characterized-by-decreased-parvalbumin-expressing-interneurons
#19
JOURNAL ARTICLE
Pablo Juarez, Maria Jimena Salcedo-Arellano, Brett Dufour, Veronica Martinez-Cerdeño
Fragile X syndrome is a genetic neurodevelopmental disorder caused by a mutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene in the X chromosome. Many fragile X syndrome cases present with autism spectrum disorder and fragile X syndrome cases account for up to 5% of all autism spectrum disorder cases. The cellular composition of the fragile X syndrome cortex is not well known. We evaluated alterations in the number of Calbindin, Calretinin, and Parvalbumin expressing interneurons across 5 different cortical areas, medial prefrontal cortex (BA46), primary somatosensory cortex (BA3), primary motor cortex (BA4), superior temporal cortex (BA22), and anterior cingulate cortex (BA24) of fragile X syndrome and neurotypical brains...
March 1, 2024: Cerebral Cortex
https://read.qxmd.com/read/38521993/shared-and-differing-functional-connectivity-abnormalities-of-the-default-mode-network-in-mild-cognitive-impairment-and-alzheimer-s-disease
#20
JOURNAL ARTICLE
Yaxuan Wang, Qian Li, Li Yao, Ning He, Yingying Tang, Lizhou Chen, Fenghua Long, Yufei Chen, Graham J Kemp, Su Lui, Fei Li
Alzheimer's disease (AD) and mild cognitive impairment (MCI) both show abnormal resting-state functional connectivity (rsFC) of default mode network (DMN), but it is unclear to what extent these abnormalities are shared. Therefore, we performed a comprehensive meta-analysis, including 31 MCI studies and 20 AD studies. MCI patients, compared to controls, showed decreased within-DMN rsFC in bilateral medial prefrontal cortex/anterior cingulate cortex (mPFC/ACC), precuneus/posterior cingulate cortex (PCC), right temporal lobes, and left angular gyrus and increased rsFC between DMN and left inferior temporal gyrus...
March 1, 2024: Cerebral Cortex
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