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Late life depression

Luboslav Stárka
Subnormal levels of testosterone are frequently found in men of higher age category. Hypogonadal men have lower life expectancy than men with full androgenization and cardiovascular disease, obesity or diabetes is often associated with hypotestosteronemia. Low testosterone level is risk factor for these diseases. However, until now it is not clear whether testosterone deficiency is a cause or consequence of atherosclerosis or metabolic syndrome. A handful of symptoms and metabolic risk markers in hypogonadal men can be ameliorated by testosterone supplementation...
2016: Vnitr̆ní Lékar̆ství
Mathilde Labbé, Katerina Nikolitch, Romeo Penheiro, Marilyn Segal, Karl J Looper, Nathan Herrmann, Steven Selchen, Soham Rej
No abstract text is available yet for this article.
September 2016: Canadian Geriatrics Journal: CGJ
David J Owen, Lorna Wood, Barbara Tomenson, Francis Creed, James P Neilson
OBJECTIVE: To investigate whether stress, anxiety and depression predict preterm birth in twin pregnancies. METHODS: A prospective cohort study with a convenience sample of women pregnant with dichorionic, diamniotic twins. They were interviewed at 24-28 weeks using the Life Events and Difficulties Schedule and the Hospital Anxiety and Depression Scale. Corticotrophin-releasing hormone, ACTH and cortisol levels were assessed at 28 weeks. The main outcome was premature delivery; there were 42 preterm and 73 term births...
October 11, 2016: Journal of Psychosomatic Obstetrics and Gynaecology
K Rosqvist, P Hagell, P Odin, H Ekström, S Iwarsson, M H Nilsson
OBJECTIVES: To identify factors associated with life satisfaction (LS) in people with Parkinson's disease (PD), including a specific focus on those with late-stage PD. MATERIAL AND METHODS: The study included 251 persons with PD (median age 70 years; PD duration 8 years). Analyses involved the total sample and a subsample with late-stage PD, that is Hoehn and Yahr stages IV and V (n=62). LS was assessed with item 1 of the Life Satisfaction Questionnaire (LiSat-11)...
October 10, 2016: Acta Neurologica Scandinavica
Elijah Mak, Sean J Colloby, Alan Thomas, John T O'Brien
Late-life depression (LLD) has been associated with both generalized and focal neuroanatomical changes including gray matter atrophy and white matter abnormalities. However, previous literature has not been consistent and, in particular, its impact on the topology organization of brain networks remains to be established. In this multimodal study, we first examined cortical thickness, and applied graph theory to investigate structural covariance networks in LLD. Thirty-three subjects with LLD and 25 controls underwent T1-weighted, fluid-attenuated inversion recovery and clinical assessments...
August 24, 2016: Neurobiology of Aging
Scott D Easton, Jooyoung Kong
Childhood sexual abuse (CSA) is a widely acknowledged trauma that affects a substantial number of boys/men and has the potential to undermine mental health across the lifespan. Despite the topic's importance, few studies have examined the long-term effects of CSA on mental health in middle and late life for men. Most empirical studies on the effects of CSA have been conducted with women, non-probability samples, and samples of young or emerging adults with inadequate control variables. Based on complex trauma theory, the current study investigated: a) the effect of CSA on mental health outcomes (depressive symptoms, somatic symptom severity, hostility) in late life for men, and b) the moderating effects of childhood adversities and masculine norms in the relationship between CSA and the three mental health outcomes...
October 5, 2016: Child Abuse & Neglect
Jurgita Kuzmickienė, Gintaras Kaubrys
BACKGROUND The primary manifestation of Alzheimer's disease (AD) is decline in memory. Dysexecutive symptoms have tremendous impact on functional activities and quality of life. Data regarding frontal-executive dysfunction in mild AD are controversial. The aim of this study was to assess the presence and specific features of executive dysfunction in mild AD based on Cambridge Neuropsychological Test Automated Battery (CANTAB) results. MATERIAL AND METHODS Fifty newly diagnosed, treatment-naïve, mild, late-onset AD patients (MMSE ≥20, AD group) and 25 control subjects (CG group) were recruited in this prospective, cross-sectional study...
October 8, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Akshya Vasudev, Amanda Arena, Amer M Burhan, Emily Ionson, Hussein Hirjee, Pramudith Maldeniya, Stephen Wetmore, Ronnie I Newman
: Late-life depression affects 2-6% of seniors aged 60 years and above. Patients are increasingly embracing non-pharmacological therapies, many of which have not been scientifically evaluated. This study aimed to evaluate a category of meditation, automatic self-transcending meditation (ASTM), in alleviating symptoms of depression when augmenting treatment as usual (NCT02149810). The preliminary results of an ongoing single-blind randomised controlled trial comparing a training programme involving ASTM with a wait-list control indicate that a 12-week ASTM programme may lead to significantly greater reductions in depression and anxiety severity...
March 2016: BJPsych Open
Sarah M Szymkowicz, Molly E McLaren, Andrew O'Shea, Adam J Woods, Stephen D Anton, Vonetta M Dotson
AIM: Major depression is associated with hippocampal volume changes, especially in late-life depression. These changes usually consist of volume reductions, but depression-related increases in hippocampal volume have also been reported. Subfield analysis has identified structural changes primarily in the cornu ammonis (CA) 1, CA2-3 and subiculum of the hippocampus in individuals with major depression; however, it is unclear whether lower levels of depressive symptoms are also associated volume reduction, or if depressive symptoms interact with age to impact hippocampal subfields...
October 2, 2016: Geriatrics & Gerontology International
Sophia Schneider, Stefanie Brassen
Brooding rumination is considered a central aspect of depression in midlife. As older people tend to review their past, rumination tendency might be particularly crucial in late life since it might hinder older adults to adequately evaluate previous events. We scanned 22 non-depressed older adults with varying degrees of brooding tendency with functional magnetic resonance imaging (MRI) while they performed the construction and elaboration of autobiographical memories. Behavioral findings demonstrate that brooders reported lower mood states, needed more time for memory construction and rated their memories as less detailed and less positive...
2016: Frontiers in Aging Neuroscience
Vitor H Pereira, Patrício S Costa, Nadine C Santos, Pedro G Cunha, Margarida Correia-Neves, Joana A Palha, Nuno Sousa
Background: Adult height, weight, and adiposity measures have been suggested by some studies to be predictors of depression, cognitive impairment, and dementia. However, the presence of confounding factors and the lack of a thorough neuropsychological evaluation in many of these studies have precluded a definitive conclusion about the influence of anthropometric measures in cognition and depression. In this study we aimed to assess the value of height, weight, and abdominal perimeter to predict cognitive impairment and depressive symptoms in aged individuals...
2016: Frontiers in Aging Neuroscience
Thomas Leyhe, Charles F Reynolds, Tobias Melcher, Christoph Linnemann, Stefan Klöppel, Kaj Blennow, Henrik Zetterberg, Bruno Dubois, Simone Lista, Harald Hampel
Late-life depression is frequently associated with cognitive impairment. Depressive symptoms are often associated with or even precede a dementia syndrome. Moreover, depressive disorders increase the risk of persistence for mild cognitive impairment and dementia. Here, we present both the current state of evidence and future perspectives regarding the integration and value of clinical assessments, neuropsychological, neurochemical, and neuroimaging biomarkers for the etiological classification of the dementia versus the depression syndrome and for the prognosis of depression relating to dementia risk...
September 28, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Alex Cohen, Amit Dias, Fredric Azariah, Revathi N Krishna, Miriam Sequeira, Sherin Abraham, Pim Cuijpers, Jennifer Q Morse, Charles F Reynolds, Vikram Patel
OBJECTIVES: The population of India is aging rapidly. This demographic shift brings with it a host of challenges to the health and well-being of older adults, including the increased prevalence of non-communicable diseases, among them depressive disorders. In this paper, we report on qualitative research intended to inform the development of a locally acceptable and appropriate intervention to improve the well-being of older adults in Goa, India and, specifically, to prevent late-life depression...
September 30, 2016: Aging & Mental Health
Jean-Pierre Michel
Already in the 90s, Khachaturian stated that postponing dementia onset by five years would decrease the prevalence of the late onset dementia by 50%. After two decades of lack of success in dementia drug discovery and development, and knowing that worldwide, currently 36 million patients have been diagnosed with Alzheimer's disease, a number that will double by 2030 and triple by 2050, the World Health Organization and the Alzheimer's Disease International declared that prevention of cognitive decline was a 'public health priority...
September 2016: Korean Journal of Family Medicine
Mona Diegelmann, Oliver K Schilling, Hans-Werner Wahl
This article examines the end-of-life development of depressive symptoms and characterizes prototypical groups following the same depressive symptoms development. We modeled time-to-death-related trajectories of depressive symptoms (Center for Epidemiologic Studies Depression Scale), applying a latent class growth analysis to deceased older adults from the English Longitudinal Study of Aging (Waves 1 to 5; NTime 1 (T1) = 2,219; MAge(T1) = 73.9 years, SDAge(T1) = 9.4 years; 51% male, 1% non-White). Four prototypical trajectories of depressive symptoms were identified at the end of life: a stably nondepressed group (31...
September 29, 2016: Psychology and Aging
Sibel Cakir, Zeynep Senkal
BACKGROUND: Second-generation antipsychotics (SGAs) have been used in the augmentation of treatment-resistant depression. However, little is known about their effectiveness, tolerability, and adverse events in the treatment of late-life depression, which were the aim of this study. METHODS: The retrospective data of patients aged >65 years who had a major depressive episode with inadequate response to antidepressant treatment and had adjuvant SGA treatment were analyzed...
2016: Clinical Interventions in Aging
J T O'Brien, P Gallagher, D Stow, N Hammerla, T Ploetz, M Firbank, C Ladha, K Ladha, D Jackson, R McNaney, I N Ferrier, P Olivier
BACKGROUND: Late-life depression (LLD) is associated with a decline in physical activity. Typically this is assessed by self-report questionnaires and, more recently, with actigraphy. We sought to explore the utility of a bespoke activity monitor to characterize activity profiles in LLD more precisely. METHOD: The activity monitor was worn for 7 days by 29 adults with LLD and 30 healthy controls. Subjects underwent neuropsychological assessment and quality of life (QoL) (36-item Short-Form Health Survey) and activities of daily living (ADL) scales (Instrumental Activities of Daily Living Scale) were administered...
September 26, 2016: Psychological Medicine
Yanfen Lin, Jian Xu, Jun Huang, Yinan Jia, Jinsong Zhang, Chonghuai Yan, Jun Zhang
BACKGROUND: Maternal stress is associated with impairments in the neurodevelopment of offspring; however, the effects of the timing of exposure to maternal stress on a child's neurodevelopment are unclear. METHODS: In 2010, we studied 225 mother-child pairs in Shanghai, recruiting mothers in mid-to-late pregnancy and monitoring offspring from birth until 30 months of age. Maternal stress was assessed prenatally (at 28-36 weeks of gestation) and postnatally (at 24-30 months postpartum) using the Symptom-Checklist-90-Revised Scale (SCL-90-R) and Life-Event-Stress Scale to evaluate mothers' emotional stress and life event stress levels, respectively...
September 19, 2016: Journal of Affective Disorders
Jai K Das, Rehana A Salam, Zohra S Lassi, Marium Naveed Khan, Wajeeha Mahmood, Vikram Patel, Zulfiqar A Bhutta
Many mental health disorders emerge in late childhood and early adolescence and contribute to the burden of these disorders among young people and later in life. We systematically reviewed literature published up to December 2015 to identify systematic reviews on mental health interventions in adolescent population. A total of 38 systematic reviews were included. We classified the included reviews into the following categories for reporting the findings: school-based interventions (n = 12); community-based interventions (n = 6); digital platforms (n = 8); and individual-/family-based interventions (n = 12)...
October 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Jeanne Lackamp, Rebecca Schlachet, Martha Sajatovic
BACKGROUND: Major depression disorder (MDD) is one of the most common mental disorders world-wide and is prevalent throughout the lifespan, with prevalence estimates of 1-5% in those 65 years of age and older. METHODS: The aim of this mini-review is to briefly summarize clinically relevant topics within the domain of later-life MDD. RESULTS: The mini-review presents an overview of epidemiology, complications of late life MDD, risk factors and clinical presentation, clinical assessment, general issues relevant to the treatment of the older adult with MDD, drug treatments, discussion of how medical complexity affects drug treatment and other treatment modalities...
September 2016: Psychiatria Danubina
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