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Late life depression

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https://www.readbyqxmd.com/read/28338875/does-baseline-hypotension-predict-incident-depression-in-a-cohort-of-community-dwelling-older-people-data-from-the-irish-longitudinal-study-on-ageing-tilda
#1
Robert Briggs, Rose Anne Kenny, Sean P Kennelly
Background: hypotension is now recognised as a risk factor for syncope, cardiovascular events and mortality, but it may also represent a risk factor for late life depression (LLD). The aim of this study was to clarify the longitudinal relationship between hypotension and incident LLD. Methods: this is a longitudinal study involving community-dwelling participants aged ≥50 years, using data from The Irish Longitudinal Study on Ageing. The Centre for Epidemiological Studies Depression Scale (CES-D) was administered at baseline and at follow-up 2 years later...
March 10, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28332247/different-pharmacological-responses-in-late-life-depression-with-subsequent-dementia-a-case-supporting-the-reserve-threshold-theory
#2
Tatsuo Akechi, Megumi Suzuki, Nobuhiko Hashimoto, Takahiro Yamada, Atsuro Yamada, Shutaro Nakaaki
No abstract text is available yet for this article.
March 23, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28324779/frontocingulate-cerebral-blood-flow-and-cerebrovascular-reactivity-associated-with-antidepressant-response-in-late-life-depression
#3
Margarita Abi Zeid Daou, Brian D Boyd, Manus J Donahue, Kimberly Albert, Warren D Taylor
BACKGROUND: Vascular pathology is common in late-life depression (LLD) and may contribute to alterations in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR). In turn, such hemodynamic deficits may adversely affect brain function and clinical course. The goal of this study was to examine whether altered cerebral hemodynamics in depressed elders predicted antidepressant response. METHODS: 21 depressed elders completed cranial 3T MRI, including a pseudo-continuous Arterial Spin Labeling (pcASL) acquisition on both room air and during a hypercapnia challenge...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28324341/beta-amyloid-deposition-in-patients-with-major-depressive-disorder-with-differing-levels-of-treatment-resistance-a-pilot-study
#4
Peng Li, Ing-Tsung Hsiao, Chia-Yih Liu, Chia-Hsiang Chen, She-Yao Huang, Tzu-Chen Yen, Kuan-Yi Wu, Kun-Ju Lin
BACKGROUND: Lack of treatment response in patients with late-life depression is common. The role of brain beta-amyloid (Aβ) deposition in treatment outcome in subjects with late-life depression remains unclear. The present study aimed to investigate brain Aβ deposition in patients with major depressive disorder (MDD) with differing treatment outcomes in vivo using (18)F-florbetapir imaging. This study included 62 MDD patients and 18 healthy control subjects (HCs).We first employed the Maudsley staging method (MSM) to categorize MDD patients into two groups according to treatment response: mild treatment resistance (n = 29) and moderate-to-severe treatment resistance (n = 33)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28323201/the-recency-ratio-is-associated-with-reduced-csf-glutamate-in-late-life-depression
#5
Davide Bruno, Jay Nierenberg, Thomas B Cooper, Charles R Marmar, Henrik Zetterberg, Kaj Blennow, Kenji Hashimoto, Nunzio Pomara
Glutamate is the principal excitatory neurotransmitter in the central nervous system, and is thought to be involved in the process of memory encoding and storage. Glutamate disturbances have also been reported in psychiatric disorders, such as schizophrenia and major depressive disorder (MDD), and in Alzheimer's disease. In this paper, we set out to study the relationship between cerebrospinal fluid (CSF) glutamate levels and memory performance, which we believe has not been reported previously. In particular, we focused on recall performance broken down by serial position...
March 18, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28318798/identification-of-childhood-abuse-in-patients-with-late-life-depression-may-help-to-optimize-treatment
#6
EDITORIAL
Elisabeth Schramm, Anneke van Schaik
No abstract text is available yet for this article.
February 24, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28318491/late-life-depression-hippocampal-volumes-and-hypothalamic-pituitary-adrenal-axis-regulation-a-systematic-review-and-meta-analysis
#7
Mirjam I Geerlings, Lotte Gerritsen
BACKGROUND: We systematically reviewed and meta-analyzed the association of late-life depression (LLD) with hippocampal volume (HCV) and total brain volume (TBV), and of cortisol levels with HCV, including subgroup analyses of depression characteristics and methodological aspects. METHODS: We searched PubMed and Embase for original studies that examined the cross-sectional relationship between LLD and HCV or TBV, and 46 studies fulfilled the inclusion criteria. Standardized mean differences (Hedges' g) between LLD and control subjects were calculated from crude or adjusted brain volumes using random effects...
January 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28317392/pharmacotherapy-of-major-depression-in-late-life-what-is-the-role-of-new-agents
#8
Kinjal Patel, Petal S Abdool, Tarek K Rajji, Benoit H Mulsant
Evidence on the pharmacotherapy of late-life major depressive disorder (LLD) is scant. Most of the recommendations in existing clinical guidelines are based on expert opinions, extrapolations from data obtained in younger patients, or theoretical considerations. AREAS COVERED This article summarizes the recommendations from existing clinical guidelines and recent reviews on the treatment of LLD. Next, it discusses the potential role of newer antidepressants -vilazodone, levomilnacipran, and vortioxetine- based on a systematic search of the literature published during the past five years...
March 20, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28295591/acetylcholinesterase-inhibitors-for-electroconvulsive-therapy-induced-cognitive-side-effects-a-systematic-review
#9
REVIEW
Marieke J Henstra, Elise P Jansma, Nathalie van der Velde, Eleonora L Swart, Max L Stek, Didi Rhebergen
OBJECTIVE: Electroconvulsive therapy (ECT) is an effective treatment for severe late-life depression; however, ECT-induced cognitive side effects frequently occur. The cholinergic system is thought to play an important role in the pathogenesis. We systematically reviewed the evidence for acetylcholinesterase inhibitors (Ache-I) to prevent or reduce ECT-induced cognitive side effects. METHODS: A systematic search was performed in Pubmed, EMBASE, PsychINFO, and the Cochrane database to identify clinical trials investigating the effect of Ache-I on ECT-induced cognitive side effects...
March 10, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28288407/therapeutic-relationship-in-the-treatment-of-geriatric-depression-with-executive-dysfunction
#10
Ryan A Mace, David A Gansler, Michael K Suvak, Carla M Gabris, Patricia A Areán, Patrick J Raue, George S Alexopoulos
BACKGROUND: The effects of therapeutic relationship (TR) in elder mental health are understudied. A greater understanding of TR in geriatric psychotherapy is particularly needed for treating late-life depression with executive dysfunction, which predicts poor response to antidepressant medication and presents unique clinical challenges. METHODS: Participants were older patients (N = 220) with major depression and executive dysfunction who received 12 weeks of problem-solving therapy or supportive therapy in a randomized control trial...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28286402/retrospective-basic-parent-child-communication-difficulties-and-risk-of-depression-in-deaf-adults
#11
Poorna Kushalnagar, Sheila Bruce, Tina Sutton, Irene W Leigh
This paper describes the relationship between retrospective communication difficulties and current depressive symptomatology. A total of 143 deaf/hard-of-hearing late adolescents and adults (64 % White; 55 % female) completed questionnaires related to parent communication, language history and current psychological functioning. Logistic regression models were used to estimate the likelihood of having depression that is associated with understanding parents' communication after controlling for gender, hearing level, and language history...
February 2017: Journal of Developmental and Physical Disabilities
https://www.readbyqxmd.com/read/28285771/improvement-in-depression-is-associated-with-improvement-in-cognition-in-late-life-psychotic-depression
#12
Lindsay W Victoria, Ellen M Whyte, Meryl A Butters, Barnett S Meyers, George S Alexopoulos, Benoit H Mulsant, Anthony J Rothschild, Samprit Banerjee, Alastair J Flint
OBJECTIVE: To characterize cognitive function at baseline and investigate the relationship between change in cognition, depression, and psychosis after treatment among older adults with major depressive disorder with psychotic features. METHODS: This was a secondary analysis of a double-blind, randomized, controlled treatment trial at inpatient and outpatient settings at four academic health centers on "Young Old" (aged 60-71 years, N = 71) and "Older" (aged 72-86 years, N = 71) participants diagnosed with psychotic depression...
February 9, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28279392/perception-of-late-effects-among-long-term-survivors-after-haematopoietic-stem-cell-transplantation-descriptive-analysis-and-validation-of-the-brief-illness-perception-questionnaire-a-sub-study-of-the-provivo-study
#13
Sabine Valenta, Sabina De Geest, Katharina Fierz, Sonja Beckmann, Jörg Halter, Urs Schanz, Gayathri Nair, Monika Kirsch
PURPOSE: To give a first description of the perception of late effects among long-term survivors after Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) and to validate the German Brief Illness Perception Questionnaire (BIPQ). METHODS: This is a secondary analysis of data from the cross-sectional, mixed-method PROVIVO study, which included 376 survivors from two Swiss HSCT-centres. First, we analysed the sample characteristics and the distribution for each BIPQ item...
April 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28271543/associations-between-pro-inflammatory-cytokines-learning-and-memory-in-late-life-depression-and-healthy-aging
#14
Rebecca A Charlton, Melissa Lamar, Aifeng Zhang, Xinguo Ren, Olusola Ajilore, Ghanshyam N Pandey, Anand Kumar
OBJECTIVES: Pro-inflammatory cytokines may play a role in learning and memory difficulties and may be exacerbated in late-life depression (LLD), where pro-inflammatory markers are already elevated because of aging and age-related vascular risk. METHODS: Learning and memory, and pro-inflammatory cytokines-Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and Interleukin-6 (IL-6) were measured in 24 individuals with LLD and 34 healthy older adults (HOA)...
March 8, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28270179/blood-cholesterol-in-late-life-and-cognitive-decline-a-longitudinal-study-of-the-chinese-elderly
#15
Chaoran Ma, Zhaoxue Yin, Pengfei Zhu, Jiesi Luo, Xiaoming Shi, Xiang Gao
BACKGROUND: Previous studies regarding the lipid-cognition relation in older adults are limited and have generated mixed results. We thus examined whether higher blood cholesterol concentrations were associated with faster cognitive decline in a community-based longitudinal study of Chinese elderly. METHODS: The study included 1,159 Chinese adults aged over 60 years (women: 48.7%, mean age: 79.4 years), who were free of dementia, Parkinson disease and stroke at the baseline...
March 7, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28266342/late-life-attachment
#16
Mélanie Freitas, Hassan Rahioui
Old age is likely to cause a crisis in one's life because of the vulnerabilities it brings up, acting as stressful elements disrupting the elder's feeling of security. It leads to the activation of what is called his attachment system, consisting in attachment styles and interpersonal emotional regulation strategies. To recover a higher sense of safety, the elder would refer to his attachment figures, that is to say closed people paying attention to him, showing towards him availability and consideration. However older adults particularly see their tolerance threshold lowered, regarding an accumulation of losses (true or symbolic) and stressful events within their lifetime...
March 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28261621/investigating-factors-associated-with-depressive-symptoms-of-chronic-kidney-diseases-in-china-with-type-2-diabetes
#17
Xu Wang, Biyu Shen, Xun Zhuang, Xueqin Wang, Weiqun Weng
Aim. To assess the depressive symptoms status of chronic kidney diseases in Nantong, China, with type 2 diabetes and to identify factors associated with depressive symptoms. Methods. In this cross-sectional analytic study, 210 type 2 diabetic patients were recruited from the Second Affiliated Hospital of Nantong University. Depressive symptoms were assessed with the depression subscale of the Hospital Anxiety and Depression Scale (HAD-D). The quality of life was measured with the RAND 36-Item Health Survey (SF-36)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28248416/cognitive-ability-in-late-life-and-onset-of-physical-frailty-the-lothian-birth-cohort-1936
#18
Catharine R Gale, Stuart J Ritchie, Cyrus Cooper, John M Starr, Ian J Deary
OBJECTIVES: To investigate whether poorer cognitive ability is a risk factor for development of physical frailty and whether this risk varies according to cognitive domain. DESIGN: Prospective longitudinal study with 6-year follow-up. SETTING: Edinburgh, Scotland. PARTICIPANTS: Members of the Lothian Birth Cohort 1936 (N = 594). MEASUREMENTS: Frailty was assessed at ages 70 and 76 using the Fried criteria...
March 1, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28245690/lack-of-a-role-for-alzheimer-s-disease-pathology-in-late-life-depression-or-just-no-relationship-with-amyloid
#19
Warren D Taylor
No abstract text is available yet for this article.
March 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28222439/trajectories-of-depression-in-late-life-a-1-year-follow-up-study
#20
Tom Borza, Knut Engedal, Sverre Bergh, Jūratė Šaltytė Benth, Geir Selbæk
AIMS: To investigate the prognosis of depression in late life (DLL) in terms of the course of depression over 1 year and assess clinical factors related to the prognosis. METHODS: We performed an observational, multicenter, longitudinal study of 160 patients aged ≥60 years who were admitted to inward treatment of DLL. The patients were followed with 3 assessments: at inclusion (T0), at discharge from the hospital (T1), and after 1 year (T2). Growth mixture modeling was applied to identify patient classes following distinct trajectories of the Montgomery-Åsberg Depression Rating Scale (MADRS) score...
February 22, 2017: Dementia and Geriatric Cognitive Disorders
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