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Late life depression

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https://www.readbyqxmd.com/read/28222439/trajectories-of-depression-in-late-life-a-1-year-follow-up-study
#1
Tom Borza, Knut Engedal, Sverre Bergh, Jūratė Šaltytė Benth, Geir Selbæk
AIMS: To investigate the prognosis of depression in late life (DLL) in terms of the course of depression over 1 year and assess clinical factors related to the prognosis. METHODS: We performed an observational, multicenter, longitudinal study of 160 patients aged ≥60 years who were admitted to inward treatment of DLL. The patients were followed with 3 assessments: at inclusion (T0), at discharge from the hospital (T1), and after 1 year (T2). Growth mixture modeling was applied to identify patient classes following distinct trajectories of the Montgomery-Åsberg Depression Rating Scale (MADRS) score...
February 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28215902/childhood-abuse-and-the-two-year-course-of-late-life-depression
#2
Ilse Wielaard, Hannie C Comijs, Max L Stek, Didi Rhebergen
OBJECTIVES: Late-life depression often has a chronic course, with debilitating effects on functioning and quality of life; there is still no consensus on important risk factors explaining this chronicity. Cross-sectional studies have shown that childhood abuse is associated with late-life depression, and in longitudinal studies with chronicity of depression in younger adults. We aim to investigate the impact of childhood abuse on the course of late-life depression. DESIGN: Two-year longitudinal cohort study...
January 24, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28211091/friendship-depression-and-suicide-attempts-in-adults-exploratory-analysis-of-a-longitudinal-follow-up-study
#3
Julia E Marver, Hanga C Galfalvy, Ainsley K Burke, M Elizabeth Sublette, Maria A Oquendo, J John Mann, Michael F Grunebaum
Social support is thought to protect against the risk of suicidal behavior in young people and late life, but less is known about the role of friendship in adults. We explored the effect of friendship on suicide attempt risk during 1-year follow-up of 132 adults presenting with major depressive episode (MDE). Items from the Social Adjustment Scale-Self-Report were used as an index of frequency and quality of recent friendship contacts. Survival methods tested associations of friendship with risk of suicide attempt, recurrent MDE, and related outcomes during follow-up...
February 17, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28210220/mri-based-classification-models-in-prediction-of-mild-cognitive-impairment-and-dementia-in-late-life-depression
#4
Aleksandra K Lebedeva, Eric Westman, Tom Borza, Mona K Beyer, Knut Engedal, Dag Aarsland, Geir Selbaek, Asta K Haberg
Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to implement interventions earlier. The purpose of this study was to assess whether structural brain magnetic resonance imaging (MRI) in LLD patients can predict mild cognitive impairment (MCI) or dementia 1 year prior to the diagnosis. Methods: LLD patients underwent brain MRI at baseline and repeated clinical assessment after 1-year...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28208078/the-characteristic-of-cognitive-dysfunction-in-remitted-late-life-depression-and-amnestic-mild-cognitive-impairment
#5
Wenxiang Liao, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, ZhiJun Zhang
Remitted late life depression exhibits persistent cognitive impairments and enhances the risk of dementia. This study aimed to examine the characteristics of cognitive dysfunction in remitted late life depression and amnestic mild cognitive impairment (MCI). Remitted late life depression (n=61), amnestic MCI (n=61) and age-education-matched controls (n=65) were evaluated with a battery of neuropsychological tests grouped into executive function, memory, processing speed, attention and visuospatial domains. Compared with control subjects, amnestic MCI individuals showed more severe cognitive impairments in all domains, while remitted late life depression individuals performed worse in executive function and memory...
January 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28202098/gene-environment-interplay-in-depressive-symptoms-moderation-by-age-sex-and-physical-illness
#6
A J Petkus, C R Beam, W Johnson, J Kaprio, T Korhonen, M McGue, J M Neiderhiser, N L Pedersen, C A Reynolds, M Gatz
BACKGROUND: Numerous factors influence late-life depressive symptoms in adults, many not thoroughly characterized. We addressed whether genetic and environmental influences on depressive symptoms differed by age, sex, and physical illness. METHOD: The analysis sample included 24 436 twins aged 40-90 years drawn from the Interplay of Genes and Environment across Multiple Studies (IGEMS) Consortium. Biometric analyses tested age, sex, and physical illness moderation of genetic and environmental variance in depressive symptoms...
February 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28198046/muscle-fatigability-and-depressive-symptoms-in-later-life
#7
Patrick J Brown, Dala Badreddine, Steven P Roose, Bret Rutherford, Hilsa N Ayonayon, Kristine Yaffe, Eleanor M Simonsick, Bret Goodpaster
OBJECTIVE: Fatigability is the degree to which performance decreases during a specific activity of a given intensity and duration. Depression is known to heighten subjective fatigue, but whether its association with physical fatigability is unknown. Further, whether fatigability is a precursor or risk factor for the development of subsequent depressive symptoms is also unclear. METHODS: Data are from the Health Aging and Body Composition Study with fatigability assessed using isokinetic dynamometry of the knee extensors at year 3, and depressive symptoms ascertained longitudinally using the Center for Epidemiologic Studies Depression (CES-D) scale...
February 15, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28193498/a-prospective-cohort-study-examining-medical-and-social-factors-associated-with-engagement-in-life-activities-following-total-hip-replacement
#8
Crystal MacKay, Fiona Webster, Viji Venkataramanan, Jessica Bytautas, Anthony V Perruccio, Rosalind Wong, Lisa Carlesso, Aileen M Davis
OBJECTIVES: Studies show limited improvement in the frequency of engaging in life activities after joint replacement. However, there is a paucity of research that has examined factors, including other life events, which influence engagement following total hip replacement (THR). This research sought to identify factors associated with engaging in life activities following THR. METHODS: A prospective cohort study was conducted with 376 people who had a THR for osteoarthritis...
February 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28175945/-neuroborreliosis-diagnostics-treatment-and-course
#9
R Dersch, S Rauer
Lyme neuroborreliosis is a tick-borne infectious disease caused by the spirochete bacterium Borrelia burgdorferi sensu lato. Clinical manifestations are classified as early and late Lyme neuroborreliosis. Early manifestations are much more common than late manifestations. Serological testing should only be performed when typical neurological symptoms are present because false positive results are common due to a high seroprevalence in the population. Cerebrospinal fluid (CSF) analysis should be performed if Lyme neuroborreliosis is suspected...
February 7, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28168438/old-man-young-man-t-s-%C3%A2-eliot-s-gerontion-and-the-problem-of-identity
#10
Moritz E Wigand, Hauke F Wiegand, Markus Jäger, Thomas Becker
BACKGROUND: In his poem Gerontion (1920) Nobel laureate T.S. Eliot uses powerful language to give a fictional, highly condensed, first-person account of medical and psychological conditions that arise with old age: physical frailty, cognitive decline, sensory impairment, depressive symptoms with embitterment, social withdrawal and the psychological strain of having to face old age and make meaning of one's life. Surprisingly, he wrote the poem as a young man. METHODS: In this qualitative study, we used a hermeneutic approach to interpret Gerontion from a psychiatric perspective...
February 6, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/28166420/does-early-life-trauma-affect-how-depression-is-experienced-by-holocaust-survivors-in-late-life
#11
Norm O'Rourke, Sara Carmel, Yaacov G Bachner
OBJECTIVES: Existing research indicates that early life trauma increases the likelihood of depression in later life. This includes children who survived the Nazi Holocaust living in Israel today. For this study, we set out to examine whether early life trauma affects both levels of depression symptomatology and the relative prominence of certain facets of depression as compared to other older adults in Israel and Canada. METHOD: For this study we recruited 295 Holocaust survivors (HS), 205 other Israelis and 335 older Canadians each of whom completed Radloff's (1977) Center for Epidemiological Studies - Depression Scale (CES-D)...
February 6, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28163495/using-multistate-observational-studies-to-determine-role-of-hypertension-and-diabetes-as-risk-factors-for-dementia
#12
Mitasha Singh, Des Raj, Sunil Kumar Raina, Manoj Kumar Gandhi, Vishav Chander
BACKGROUND: Evidence suggests that modifiable risk factors which can be targeted by prevention are vascular diseases, such as diabetes, midlife hypertension (HTN), midlife obesity, midlife cholesterol, mid- and late-life depression as well as lifestyle factors such as smoking, physical inactivity, and poor diet. METHODS: A comprehensive search of the National Library of Medicine's PubMed database and Google Scholar was conducted. A combinations of medical subject headings and free text words that included search terms related to the exposure (e...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28162112/hoarding-in-the-elderly-a-critical-review-of-the-recent-literature
#13
David M Roane, Alyssa Landers, Jackson Sherratt, Gillian S Wilson
BACKGROUND: Hoarding is now a stand-alone diagnosis in DSM-5. The objective of this review is to critically evaluate the most recent literature on hoarding disorder (HD) in ageing patients. METHODS: A literature search was conducted using PubMed and PsychINFO to identify papers from 2000 to 2015 that examined HD and hoarding symptoms in late-life participants. RESULTS: Thirteen studies met inclusion criteria. Selected studies had significant methodological limitations with regard to participant sampling, diagnostic criteria, and methods for identifying co-morbid conditions...
February 6, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28161971/assessment-of-implicit-self-esteem-in-older-adults
#14
Ineke Demeyer, Nuria Romero, Rudi De Raedt
The interplay between actual and ideal self-esteem may be a key component in emotional disorders. Since automatic self-evaluations are not always consciously accessible, assessment through implicit measures is necessary. Given the lack of implicit self-esteem measures in late life, we aimed to identify a reliable measure and to clarify the role of actual and ideal self-esteem in mood and depressive symptoms in older adults. Forty-nine older adults completed two adapted Go/No go Association tasks measuring implicit actual and ideal self-esteem and measures of mood and depressive symptoms...
February 1, 2017: Assessment
https://www.readbyqxmd.com/read/28152564/age-of-onset-and-family-history-as-indicators-of-polygenic-risk-for-major-depression
#15
Anna R Docherty, Alexis C Edwards, Fuzhong Yang, Roseann E Peterson, Chelsea Sawyers, Daniel E Adkins, Ashlee A Moore, Bradley T Webb, Silviu A Bacanu, Jonathan Flint, Kenneth S Kendler
BACKGROUND: The extent to which earlier age of onset (AO) is a reflection of increased genetic risk for major depression (MD) is still unknown. Previous biometrical research has provided mixed empirical evidence for the genetic overlap of AO with MD. If AO is demonstrated to be relevant to molecular polygenic risk for MD, incorporation of AO as a phenotype could enhance future genetic studies. METHODS: This research estimated the SNP-based heritability of AO in the China, Oxford and VCU Experimental Research on Genetic Epidemiology (CONVERGE) case-control sample (N = 9,854; MD case, n = 4,927)...
February 2, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28138119/the-normalization-of-brain-%C3%A2-%C3%A2-f-fluorodeoxy-d-glucose-positron-emission-tomography-hypometabolism-following-electroconvulsive-therapy-in-a-55-year-old-woman-with-treatment-resistant-late-onset-depression-a-case-report
#16
Jeongjae Bak, Sang Mi Lee, Young-Joon Kwon, Se-Hoon Shim, Joong Il Kim
Major depressive disorder, especially in later life, has heterogeneous clinical characteristics and treatment responses. Symptomatically, psychomotor retardation, lack of energy, and apathy tends to be more common in people with late-onset depression (LOD). Despite recent advances in psychopharmacologic treatments, 20% to 30% of patients with mood disorders experience inadequate responses to medication, often resulting in a trial of electroconvulsive therapy (ECT). However, the therapeutic mechanism of ECT is still unclear...
February 28, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28137459/systematic-review-and-meta-analysis-of-genetic-studies-of-late-life-depression
#17
REVIEW
Ruby S M Tsang, Karen A Mather, Perminder S Sachdev, Simone Reppermund
Late-life depression (LLD) is thought to be multifactorial in etiology, including a significant genetic component. While a number of candidate gene studies have been carried out, results remain inconclusive. We undertook a systematic review of all genetic association studies of depression or depressive symptoms in late life published before February 2016, and performed meta-analyses on polymorphisms investigated in three or more independent studies. A total of 46 candidate gene studies examining 56 polymorphisms in 23 genes as well as a genome-wide association study (GWAS) were included...
January 27, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28135816/the-youth-mood-clinic-an-innovative-service-for-the-treatment-of-severe-and-complex-depression
#18
Simon M Rice, Steve Halperin, Sara Cahill, Ingrid Cranston, Mark Phelan, Sarah E Hetrick, Simon Blaikie, Jane Edwards, John Koutsogiannis, Christopher G Davey
OBJECTIVE: Depression is the leading cause of disability for Australians from late adolescence through mid-adulthood, and effective treatments can positively impact subsequent life course trajectories. A treatment model for the management of complex youth depression, characterised by symptom severity, multi-morbidity and ongoing suicidality is presented. CONCLUSIONS: The Youth Mood Clinic (YMC) provides multidisciplinary, team-based treatment for young people aged 15-25 years...
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28130887/neural-correlates-of-apathy-in-late-life-depression-a-pilot-18-f-fddnp-positron-emission-tomography-study
#19
Harris A Eyre, Prabha Siddarth, Kathleen van Dyk, Natalie St Cyr, Bernhard T Baune, Jorge R Barrio, Gary W Small, Helen Lavretsky
BACKGROUND: Neurotoxicity associated with amyloid and tau protein aggregation could represent a pathophysiological cascade that, along with vascular compromise, may predispose individuals to late-life depression (LLD). In LLD, apathy is common, leads to worsening of functioning, and responds poorly to antidepressant treatment. Better understanding of the pathophysiological mechanisms of apathy in LLD would facilitate development of more effective diagnostic and treatment approaches. In this cross-sectional pilot study, we performed positron emission tomography scans after injection of 2-(1-{6-[(2-[(18) F]fluoroethyl)(methyl)-amino]-2-naphthyl}ethylidene) malononitrile ([(18) F]FDDNP), an in vivo amyloid and tau neuroimaging study, in patients with LLD to explore neural correlates of apathy...
January 28, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28124802/the-interventional-relationship-between-frequent-fish-consumption-and-depression-symptoms-in-aging-adults-a-randomized-controlled-trial
#20
Payam Sharifan, Motahare-Sadat Hosseini, Anoosheh Sharifan
OBJECTIVE: The present investigation was intended to test the hypothesis that the elderly provided with the frequent consumption of fishes marinated in essential oil of Perilla frutescens (EOPF) or not would experience fewer depressive symptoms after 6 months. METHODS: A total of 180 participants were recruited from Sina Hospital, Mashhad, Iran, who were diagnosed with depression based on Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision and Beck Depression Inventory...
January 26, 2017: International Journal of Geriatric Psychiatry
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