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Late life depression

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https://www.readbyqxmd.com/read/29785803/depressive-spectrum-states-in-a-population-based-cohort-of-70-year-olds-followed-over-9-years
#1
Robert Sigström, Margda Waern, Pia Gudmundsson, Ingmar Skoog, Svante Östling
OBJECTIVE: Depression may be understood as a spectrum of more or less symptomatic states. Little is known about the long-term course of these states in older populations. We examined the prevalence and course of depressive states of different severity in a Swedish population sample of older people followed over 9 years. METHODS: A population-based sample of 70-year olds without dementia (N = 563, response rate 71.1%) underwent a psychiatric examination; 450 survivors without dementia were reexamined at ages 75 and/or 79 years...
May 21, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29783176/%C3%AF-3-and-folic-acid-act-against-depressive-like-behavior-and-oxidative-damage-in-the-brain-of-rats-subjected-to-early-or-late-life-stress
#2
Gislaine Z Réus, Amanda L Maciel, Helena M Abelaira, Airam B de Moura, Thays G de Souza, Thais R Dos Santos, Ana Caroline Darabas, Murilo Parzianello, Danyela Matos, Mariane Abatti, Ana Carolina Vieira, Vanessa Fucillini, Monique Michels, Felipe Dal-Pizzol, João Quevedo
OBJECTIVES: To investigate the antidepressant and antioxidant effects of omega-3, folic acid and n-acetylcysteine (NAC) in rats which were subjected to early or late life stress. METHODS: Early stress was induced through maternal deprivation (MD), while late life stress was induced using the chronic mild stress (CMS) protocol. Young rats which were subjected to MD and the adult rats which were subjected to CMS were treated with omega-3 fatty acids (0.72 g/kg), NAC (20 mg/kg) or folic acid (50 mg/kg) once/day, for a period of 20 days...
March 30, 2018: Nutrition
https://www.readbyqxmd.com/read/29783163/maternal-hypothalamus-pituitary-adrenal-hpa-system-activity-and-stress-during-pregnancy-effects-on-gestational-age-and-infant-s-anthropometric-measures-at-birth
#3
Maria Gilles, Henrike Otto, Isabell A C Wolf, Barbara Scharnholz, Verena Peus, Michael Schredl, Marc W Sütterlin, Stephanie H Witt, Marcella Rietschel, Manfred Laucht, Michael Deuschle
BACKGROUND: Prenatal maternal stress might be a risk for the developing fetus and may have long-lasting effects on child and adult vulnerability to somatic and psychiatric disease. Over-exposure of the unborn to excess glucocorticoids and subsequent alteration of fetal development is hypothesized to be one of the key mechanisms linking prenatal stress with negative child outcome. METHODS: In this prospective longitudinal study, mothers-to-be (n = 405) in late pregnancy (36...
April 22, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29754022/resilience-and-amygdala-function-in-older-healthy-and-depressed-adults
#4
Amber M Leaver, Hongyu Yang, Prabha Siddarth, Roza M Vlasova, Beatrix Krause, Natalie St Cyr, Katherine L Narr, Helen Lavretsky
BACKGROUND: Previous studies suggest that low emotional resilience may correspond with increased or over-active amygdala function. Complementary studies suggest that emotional resilience increases with age; older adults tend to have decreased attentional bias to negative stimuli compared to younger adults. Amygdala nuclei and related brain circuits have been linked to negative affect, and depressed patients have been demonstrated to have abnormal amygdala function. METHODS: In the current study, we correlated psychological resilience measures with amygdala function measured with resting-state arterial spin-labelled (ASL) and blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in older adults with and without depression...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29749006/predictors-of-recurrence-in-remitted-late-life-depression
#5
Yi Deng, Douglas R McQuoid, Guy G Potter, David C Steffens, Kimberly Albert, Meghan Riddle, John L Beyer, Warren D Taylor
BACKGROUND: Late-life depression (LLD) is associated with a fragile antidepressant response and high recurrence risk. This study examined what measures predict recurrence in remitted LLD. METHODS: Individuals of age 60 years or older with a Diagnostic and Statistical Manual - IV (DSM-IV) diagnosis of major depressive disorder were enrolled in the neurocognitive outcomes of depression in the elderly study. Participants received manualized antidepressant treatment and were followed longitudinally for an average of 5 years...
May 10, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29734852/somatic-complaints-in-adolescence-and-labour-market-participation-in-young-adulthood
#6
Trine Nøhr Winding, Johan Hviid Andersen
AIMS: The primary aim was to investigate the association between somatic symptoms at ages 15 or 18 and reduced labour market participation at age 23, when socioeconomic, social, and mental health risk factors were taken into account. METHODS: The study included 3223 participants from the West Jutland Cohort Study with questionnaire information on somatic symptoms at ages 15 or 18 and with register information on labour market participation at age 23, gathered from a national register on all public transfer benefits for a 52-week period...
May 1, 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29724663/effect-of-problem-solving-therapy-versus-supportive-management-in-older-adults-with-low-back-pain-and-depression-while-on-antidepressant-pharmacotherapy
#7
Jordan F Karp, Xiaotian Gao, Abdus S Wahed, Jennifer Q Morse, Bruce L Rollman, Debra K Weiner, Charles F Reynolds
OBJECTIVE: Testing stepped-care approaches that address both depression and low back pain are needed to optimize outcomes in older adults. METHODS: This university-based late-life depression research center assessed 227 adults aged ≥ 60 years with chronic low back pain and depression. In Phase 1 participants received 6 weeks of low-dose venlafaxine (≤150 mg/day). Nonresponders were randomized to 10 weeks of high-dose venlafaxine (up to 300 mg/day) plus problem-solving therapy (PST) or high-dose venlafaxine with supportive management...
March 30, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29723962/weight-shame-social-connection-and-depressive-symptoms-in-late-adolescence
#8
Alexandra A Brewis, Meg Bruening
Child and adolescent obesity is increasingly the focus of interventions, because it predicts serious disease morbidity later in life. However, social environments that permit weight-related stigma and body shame may make weight control and loss more difficult. Rarely do youth obesity interventions address these complexities. Drawing on repeated measures in a large sample ( N = 1443) of first-year (freshman), campus-resident university students across a nine-month period, we model how weight-related shame predicts depressive symptom levels, how being overweight (assessed by anthropometric measures) shapes that risk, and how social connection (openness to friendship) might mediate/moderate...
May 1, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29717755/mediterranean-diet-food-consumption-and-risk-of-late-life-depression-the-mugello-study
#9
G Pagliai, F Sofi, F Vannetti, S Caiani, G Pasquini, R Molino Lova, F Cecchi, S Sorbi, C Macchi
OBJECTIVES: To investigate eating habits and adherence to Mediterranean Diet (MD) in relation to the risk of depression in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues, including those related to nutritional status. DESIGN: Cross-sectional study. SETTING: Homes and nursing homes in the Mugello area, Florence, Italy...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29712690/support-for-midlife-anxiety-diagnosis-as-an-independent-risk-factor-for-dementia-a-systematic-review
#10
Amy Gimson, Marco Schlosser, Jonathan D Huntley, Natalie L Marchant
OBJECTIVES: Anxiety is an increasingly recognised predictor of cognitive deterioration in older adults and in those with mild cognitive impairment. Often believed to be a prodromal feature of neurodegenerative disease, anxiety may also be an independent risk factor for dementia, operationally defined here as preceding dementia diagnosis by ≥10 years. DESIGN: A systematic review of the literature on anxiety diagnosis and long-term risk for dementia was performed following published guidelines...
April 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29709510/subjective-but-not-objective-sleep-is-associated-with-subsyndromal-anxiety-and-depression-in-community-dwelling-older-adults
#11
Christine E Gould, Rosy Karna, Josh Jordan, Makoto Kawai, Rayna Hirst, Nathan Hantke, Sophia Pirog, Isabelle Cotto, Sophia Miryam Schussler-Fiorenza Rose, Sherry A Beaudreau, Ruth O'Hara
OBJECTIVE: To examine the relationship between subclinical anxiety and depressive symptoms and objective sleep architecture measures and subjective sleep reports in older adults. METHODS: Community-dwelling older adults (N = 167) self-rated their current severity of anxiety symptoms, depressive symptoms, daytime sleepiness, and global sleep quality. Participants received overnight ambulatory polysomnography to assess sleep architecture. Multivariate linear regression models examined associations between anxiety and depressive symptoms and objective and subjective sleep measures...
March 27, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29699779/the-psychosocial-effects-of-perioperative-complications-after-bariatric-surgery
#12
Karen Ho, Raed Hawa, Susan Wnuk, Allan Okrainec, Timothy Jackson, Sanjeev Sockalingam
BACKGROUND: Bariatric surgery is an effective weight loss tool that results in sustained weight loss, improvement in obesity-related comorbidities, and positive psychosocial outcomes. However, bariatric procedures also present with risks, as surgical complications are not uncommon. OBJECTIVE: This study aims to better understand the effect of postoperative complications from bariatric surgeries on patients' psychosocial well-being. MATERIALS AND METHODS: Surgical data on postoperative complications were matched with results from self-administered psychosocial questionnaires...
March 21, 2018: Psychosomatics
https://www.readbyqxmd.com/read/29696998/understanding-body-image-among-adults-in-mid-late-life-considering-romantic-partners-and-depressive-symptoms-in-the-context-of-diabetes
#13
Charlotte H Markey, Kristin J August, Jamie L Dunaev
Although our bodies change as we age, there is limited research exploring body image among middle-aged and older adults. This study considered 70 adults with diabetes' ( Mage = 60.01 years) body image and revealed relatively high levels of body dissatisfaction in this sample. Furthermore, participants' own and perceptions of their partners' dissatisfaction with their bodies were moderately associated, and participants' body dissatisfaction was associated with higher levels of depressive symptoms. These findings highlight the need for further research, exploring the social and psychological correlates of body image among men and women in mid-late adulthood...
April 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29694972/quality-of-life-in-people-with-young-onset-alzheimer-s-dementia-and-frontotemporal-dementia
#14
Lara Hvidsten, Knut Engedal, Geir Selbæk, Torgeir Bruun Wyller, Frøydis Bruvik, Hege Kersten
AIMS: The aims of this study were to compare quality of life (QOL) in people with young-onset Alzheimer's (AD) and frontotemporal (FTD) dementia, explore variables associated with QOL, and compare QOL in young-onset dementia (YOD) and late-onset dementia (LOD). METHODS: Cross-sectional data from a Nordic multicenter study of 50 community-dwelling participants with AD and 38 with FTD were included. A comparison group consisted of 100 people with LOD. QOL was measured using self-reported Euro-QOL 5-Dimension and the proxy version of Quality of Life in Alzheimer's Disease (QOL-AD) questionnaire...
April 25, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29689582/-late-life-depression-diagnosis-pathophysiology-and-therapeutic-strategies
#15
Forugh S Dafsari, Frank Jessen
Late-life depression is a frequent and severe mental disorder. It is characterized by alterations in mood as well as cognitive deficits and somatic symptoms. LLD is associated with various adverse outcomes, such as reduced quality of life, negative impact on physical comorbidities, functional impairments, increased suicide and non-suicide mortality. Moreover, LLD serves as a risk factor for developing all-cause dementia, including Alzheimer´s disease. It leads to a frequent use of health care services and remains a serious public health concern...
April 2018: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29679898/heart-rate-variability-alterations-in-late-life-depression-a-meta-analysis
#16
REVIEW
Lydia Brown, Chandan Karmakar, Richard Gray, Ripu Jindal, Terrence Lim, Christina Bryant
OBJECTIVE: There is strong evidence for a bi-directional relationship between heart-health and depression in later life, but the physiological mechanisms underlying this relationship remain unclear. Heart rate variability is one promising factor that might help explain this relationship. We present results of a meta-analysis that considers heart rate variability alterations in older adults with depression. METHODS: Literature search of Embase, PsychInfo and Medline revealed five clinical studies and six observational studies that examined the relationship between heart rate variability and depression in adults with a mean age over 60...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29676436/is-a-decline-in-will-to-live-a-consequence-or-predictor-of-depression-in-late-life
#17
Sara Carmel, Hava Tovel, Victoria H Raveis, Norm O'Rourke
OBJECTIVES: To assess the causal directions of interaction between depression and decline in will to live (WTL) over 2 years in community-dwelling older adults. DESIGN: Community-based longitudinal study. SETTING: Three large cities in Israel. PARTICIPANTS: Individuals aged 75 and older (N=870). MEASUREMENTS: We tested a cross-lagged structural equation model in which WTL and depressive symptoms (DS) were tested as latent variables at each of three annual points of measurement...
April 20, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29661060/mental-work-demands-and-late-life-cognitive-impairment-results-from-the-shanghai-aging-study
#18
Xiaoniu Liang, Zhao Chen, Xinqi Dong, Qianhua Zhao, Qihao Guo, Li Zheng, Wei Deng, Jianfeng Luo, Ding Ding
OBJECTIVE: The aim of this study is to explore the association between mental work demands (MWDs) and late-life cognition among Chinese older adults. METHOD: Data were drawn from the baseline of the Shanghai Aging Study. RESULTS: Among 3,546 participants, the mean MWDs index of participants with dementia, mild cognitive impairment (MCI), and cognitive normal were 2.8 ( SD = 0.5), 2.8 ( SD = 0.5), and 2.9 ( SD = 0.4), respectively. Mini Mental State Examination (MMSE) scores in group with low MWDs level decreased more dramatically by increasing age than that in groups with middle and high MWDs level ( p < ...
April 1, 2018: Journal of Aging and Health
https://www.readbyqxmd.com/read/29659205/executive-function-predicts-antidepressant-treatment-noncompletion-in-late-life-depression
#19
Pilar Cristancho, Eric J Lenze, David Dixon, J Philip Miller, Benoit H Mulsant, Charles F Reynolds, Meryl A Butters
OBJECTIVE: To examine whether executive function (EF) is associated with nonremission and noncompletion of antidepressant pharmacotherapy in older adults with depression. DESIGN: In this prospective study (July 2009 to May 2014), older adults (aged ≥ 60 years; n = 468) with a DSM-IV-defined major depressive episode diagnosed via structured interview received 12 weeks of venlafaxine extended release with the goal of achieving remission. A hypothesis was made that worse baseline EF would predict both nonremission and noncompletion (primary outcomes)...
April 3, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29659008/commentary-on-neural-systems-in-late-life-depression-clinical-presentation-and-treatment-outcome
#20
Kathy D Wright
No abstract text is available yet for this article.
April 2018: Journal of the American Geriatrics Society
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