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Late life depression

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https://www.readbyqxmd.com/read/28917197/adolescent-socioeconomic-status-and-depressive-symptoms-in-later-life-evidence-from-structural-equation-models
#1
Elizabeth C Pino, Karla Damus, Brian Jack, David Henderson, Snezana Milanovic, Bindu Kalesan
BACKGROUND: The complex association between socioeconomic status (SES) and depressive symptoms is not entirely understood and the existing literature does not address the relationship between early-life SES and later-life depression from a life-course perspective, incorporating mediating events. METHODS: Using data from the Wisconsin Longitudinal Study, we employed structural equation modeling to examine how SES measured at age 18 affects depressive symptoms at age 54 directly and through mediating variables college graduation, marriage, and household income level at age 36...
September 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28900387/social-isolation-in-early-versus-late-adolescent-mice-is-associated-with-persistent-behavioral-deficits-that-can-be-improved-by-neurosteroid-based-treatment
#2
Andrea Locci, Philippe Geoffroy, Michel Miesch, Ayikoe-Guy Mensah-Nyagan, Graziano Pinna
Early trauma and stress exposure during a critical period of life may increase the risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) in adulthood. The first-choice treatment for MDD and PTSD are selective serotonin reuptake inhibitor (SSRI) antidepressants. Unfortunately, half of MDD and PTSD patients show resistance to the therapeutic effects of these drugs and more efficient treatments are essential. Both MDD and PTSD patients present reduced levels of allopregnanolone (Allo), a potent endogenous positive allosteric modulator of GABA action at GABAA receptors which are normalized by SSRIs in treatment responders...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28892767/negative-bias-in-expression-related-mismatch-negativity-mmn-in-remitted-late-life-depression-an-event-related-potential-study
#3
Zhangying Wu, Xiaomei Zhong, Qi Peng, Ben Chen, Naikeng Mai, Yuping Ning
Negative bias in cognition is closely associated with susceptibility to recurrent episodes of depression. Given the high recurrence rate of depression, previous studies have focused on the attentive level in late-life depression (LLD), but depression relapse is difficult to detect as a lower chief complaint in elderly people. Facial expression mismatch negativity (EMMN) is a tool that can measure cognitive bias in pre-attentive processing. In this study, we sought to explore the cognitive bias in pre-attentive emotional information processing in LLD...
August 31, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28887605/the-possible-protective-effect-of-marital-status-in-quality-of-life-among-elders-in-a-u-s-mexico-border-city
#4
Marisela Gutiérrez-Vega, Oscar Armando Esparza-Del Villar, Irene Concepción Carrillo-Saucedo, Priscila Montañez-Alvarado
The purpose of this study was to determine how marital status may have an impact on quality of life in a group of older adults living in a U.S.-Mexico border city. Two-hundred and seventy-six older adults completed the Spanish version of the World Health Organization Quality of Life Assessment, composed of four domains: physical health, psychological health, social relationships, and environment. Participants answered a measure of sociodemographic variables. In the psychological health component of quality of life, single and married older adults had the highest scores as compared to widowed and divorced...
September 8, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28884712/-clinical-and-neurovisualization-characteristics-of-apathetic-depression
#5
A S Avedisova, K V Zakharova, V V Gaskin, I S Samotaeva, I A Arkusha
AIM: To study apathetic depression first diagnosed at late age and identify its relation to cognitive and social dysfunction as well as to morphological and functional changes in the brain. MATERIAL AND METHODS: Thirty-two patients at the age above 60 years with newly diagnosed depressive episode and 15 healthy age-matched volunteers were included in the study. All patients were divided into two groups by the score on the Apathy scale (AS): >14 - depression with apathy (n=21), <14 - depression without apathy (n=11)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28883770/frequency-of-depression-and-its-correlation-with-quality-of-life-of-patients-with-oral-cavity-cancer
#6
Senada Dzebo, Jasmina Mahmutovic, Hasiba Erkocevic, Faris Foco
INTRODUCTION: the effects of malignant tumors of oral cavity may be reflected through mental, physical, social and emotional well-being and quality of life of patients. Those suffering from malignancies show a large degree of psychological problems (fear, anxiety, depression, panic disorders, phobias) both at the time of diagnosis and during the treatment. AIM: to determine a level of depression in patients with oral cavity cancer and to link quality of life and level of depression of patients with oral cavity cancer...
June 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28878666/weight-rich-club-analysis-in-the-white-matter-network-of-late-life-depression-with-memory-deficits
#7
Naikeng Mai, Xiaomei Zhong, Ben Chen, Qi Peng, Zhangying Wu, Weiru Zhang, Cong Ouyang, Yuping Ning
Patients with late-life depression (LLD) have a higher incident of developing dementia, especially individuals with memory deficits. However, little is known about the white matter characteristics of LLD with memory deficits (LLD-MD) in the human connectome, especially for the rich-club coefficient, which is an indicator that describes the organization pattern of hub in the network. To address this question, diffusion tensor imaging of 69 participants [15 LLD-MD patients; 24 patients with LLD with intact memory (LLD-IM); and 30 healthy controls (HC)] was applied to construct a brain network for each individual...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28869033/life-course-of-children-with-parental-multiple-sclerosis
#8
Julie Yoon Moberg
BACKGROUND: The majority of persons with multiple sclerosis (MS) experience onset of MS between the ages of 20 and 40. Since two-thirds of the persons with MS are young women of childbearing age, parenthood is an essential issue during this period of life. The potential influence of parental MS on children arises from the varied symptoms of the chronic illness, which affect physical and cognitive abilities. MS disabilities and fatigue can restrict daily life and result in less energy for activities or job loss and thus worse conditions for the family...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28862491/eye-gaze-control-technology-for-children-adolescents-and-adults-with-cerebral-palsy-with-significant-physical-disability-findings-from-a-systematic-review
#9
Petra Karlsson, Abigail Allsop, Betty-Jean Dee-Price, Margaret Wallen
PURPOSE: The primary objective of this systematic review was to examine the effectiveness of eye-gaze control technology for facilitating communication across different social contexts for people with cerebral palsy and significant physical disability. METHODS: Systematic review. RESULTS: The search identified 756 potentially eligible articles, of which two, low level articles were eligible. One study reported positive results for achieving communication goals for children with cerebral palsy...
September 1, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28860774/bipolar-ii-disorder-as-the-initial-presentation-of-cadasil-an-underdiagnosed-manifestation
#10
Jianjun Wang, Jinfang Li, Fanxin Kong, Hanqing Lv, Zhouke Guo
Mood disturbances have been documented in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The highly varied morbidity indicates that the affective symptoms in CADASIL have not been cataloged systematically, leading to ineffective treatment, affecting the patients' quality of life, and possibly resulting in suicide. We present a case of CADASIL with bipolar II disorder as the first manifestation. A middle-aged female reported recurrent depressive episodes and appeared treatment resistant to adequate dosages and durations of antidepressants...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28859996/nicotine-and-networks-potential-for-enhancement-of-mood-and-cognition-in-late-life-depression
#11
REVIEW
Jason A Gandelman, Paul Newhouse, Warren D Taylor
Late-life depression is characterized by both lower mood and poor cognitive performance, symptoms that often do not fully respond to current antidepressant medications. Nicotinic acetylcholine receptor (nAChR) agonists such as nicotine may serve as a novel therapeutic approach for this population. Both preclinical and preliminary clinical studies suggest that nAChR agonists can improve depressive behavior in animal models and improve mood in depressed individuals. Substantial literature also supports that nAChR agonists benefit cognitive performance, particularly in older populations...
August 30, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28857651/gray-matter-structural-networks-are-associated-with-cardiovascular-risk-factors-in-healthy-older-adults
#12
Shahrzad Kharabian Masouleh, Frauke Beyer, Leonie Lampe, Markus Loeffler, Tobias Luck, Steffi G Riedel-Heller, Matthias L Schroeter, Michael Stumvoll, Arno Villringer, A Veronica Witte
While recent 'big data' analyses discovered structural brain networks that alter with age and relate to cognitive decline, identifying modifiable factors that prevent these changes remains a major challenge. We therefore aimed to determine the effects of common cardiovascular risk factors on vulnerable gray matter (GM) networks in a large and well-characterized population-based cohort. In 616 healthy elderly (258 women, 60-80 years) of the LIFE-Adult-Study, we assessed the effects of obesity, smoking, blood pressure, markers of glucose and lipid metabolism as well as physical activity on major GM-networks derived using linked independent component analysis...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28843842/association-between-change-in-brain-gray-matter-volume-cognition-and-depression-severity-pre-and-post-antidepressant-pharmacotherapy-for-late-life-depression
#13
K Droppa, H T Karim, D L Tudorascu, J F Karp, C F Reynolds, H J Aizenstein, M A Butters
Late-life depression (LLD) is associated with cognitive impairments and reduced gray matter volume (GMV); however the mechanisms underlying this association are not well understood. The goal of this study was to characterize changes in depression severity, cognitive function, and brain structure associated with pharmacologic antidepressant treatment for LLD. We administered a detailed neurocognitive battery and conducted structural magnetic resonance imaging (MRI) on 26 individuals with LLD, pre-/post-a 12-week treatment trial with venlafaxine...
August 8, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28826692/atypical-antipsychotic-prescribing-in-elderly-patients-with-depression
#14
Sanika Rege, Sneha Sura, Rajender R Aparasu
BACKGROUND: Atypical antipsychotics are used as monotherapy or as augmentation therapy for management of late-life depression. However, little is known about utilization pattern of atypical antipsychotics in depression in the elderly. OBJECTIVE: The objective of this study was to examine the prescribing practices and predictors of atypical antipsychotics and augmentation therapy in elderly outpatient visits with depression. METHODS: This retrospective cross-sectional study used the National Ambulatory Medical Care Survey (NAMCS) and outpatient department component of the National Hospital Ambulatory Medical Care Survey (NHAMCS) data from 2010 and 2011...
August 2, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28821515/does-the-person-s-context-influence-engagement-in-life-activities-following-primary-knee-replacement-results-from-a-canadian-prospective-cohort-study
#15
Aileen M Davis, Viji Venkataramanan, Jessica Bytautas-Sillanpää, Anthony V Perruccio, Rosalind Wong, Lisa Carlesso, Fiona Webster
OBJECTIVE: The impact of the context of a person's life on recovery from surgical interventions is not well understood. This study evaluated if people's social, environmental and biomedical context was associated with change in frequency in engagement in life activities after total knee replacement (TKR). METHODS: 418 people aged 30+ years who had TKR were followed presurgery to 1 year postsurgery. The outcome was change in frequency in engagement in life activities measured by the Late Life Disability Index (LLDI)...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28807701/late-life-suicide-in-terminal-cancer-a-rational-act-or-under-diagnosed-depression
#16
Gary Cheung, Gwendolyn Douwes, Frederick Sundram
CONTEXT: Previous studies have reported significantly elevated standardised mortality rates in older people with cancer. Terminally ill people represent a unique group where suicide may be considered as rational. OBJECTIVES: The aims of this study are to (i) compare the socio-demographic and clinical characteristics of older people with and without terminal cancer who died by suicide, and (ii) analyze the suicide motives of those with terminal cancer to determine whether they represent rational suicide...
August 11, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28807498/vascular-pathology-and-trajectories-of-late-life-major-depressive-disorder-in-secondary-psychiatric-care
#17
Katherine L Musliner, Peter P Zandi, Xiaoqin Liu, Thomas M Laursen, Trine Munk-Olsen, Preben B Mortensen, William W Eaton
OBJECTIVE: To examine 5-year trajectories of psychiatrist-treated late-life major depressive disorder (MDD), and evaluate whether previous vascular pathology is associated with more severe trajectories of late-life MDD. METHODS: Data were obtained from nationally representative civil, psychiatric, hospital, and prescription registers in Denmark. The sample included 11,092 older adults (≥60 years) who received their first diagnosis of MDD in a psychiatric facility in Denmark between 2000 and 2007...
July 12, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28805571/palliative-care-and-nonmotor-symptoms-in-parkinson-s-disease-and-parkinsonism
#18
Nataliya Titova, K Ray Chaudhuri
The term palliative care (PC) is defined as a collection of interventions and strategies that helps to improve and sustain the quality of life of patients and caregivers in situations and scenarios associated with life-threatening illness. This is usually implemented by means of early identification and treatment of relevant motor and nonmotor issues such as pain, sleep, and autonomic dysfunction, dementia, and depression. In addition, a holistic PC program also includes delivery of physical, psychosocial, and spiritual support...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28801113/internet-delivery-and-peer-support-new-venues-for-psychosocial-interventions-of-late-life-depression
#19
EDITORIAL
Dimitris N Kiosses
No abstract text is available yet for this article.
July 8, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28782980/psychometric-properties-of-the-spanish-version-of-the-adolescent-stress-questionnaire-asq-s
#20
Juan F Lima, Rafael Alarcón, Milagros Escobar, F Javier Fernández-Baena, Ángela M Muñoz, María J Blanca
The aim of this study was to develop a Spanish version of the Adolescent Stress Questionnaire and to examine its psychometric properties: factor structure, measurement invariance across samples, reliability, and concurrent validity. Participants consisted of 1,560 Spanish students between 12 and 18 years of age. The results support a structure based on 10 first-order factors (corresponding to stressors on the dimensions Home Life, School Performance, School Attendance, Romantic Relationships, Peer Pressure, Teacher Interaction, Future Uncertainty, School/Leisure Conflict, Financial Pressure, and Emerging Adult Responsibility) and 1 second-order factor that subsumes the first-order factors...
August 7, 2017: Psychological Assessment
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