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Geriatric depression

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https://www.readbyqxmd.com/read/28739263/pilot-randomized-controlled-trial-of-titrated-subcutaneous-ketamine-in-older-patients-with-treatment-resistant-depression
#1
Duncan George, Verònica Gálvez, Donel Martin, Divya Kumar, John Leyden, Dusan Hadzi-Pavlovic, Simon Harper, Henry Brodaty, Paul Glue, Rohan Taylor, Philip B Mitchell, Colleen K Loo
OBJECTIVE: To assess the efficacy and safety of subcutaneous ketamine for geriatric treatment-resistant depression. Secondary aims were to examine if repeated treatments were safe and more effective in inducing or prolonging remission than a single treatment. METHODS: In this double-blind, controlled, multiple-crossover study with a 6-month follow-up (randomized controlled trial [RCT] phase), 16 participants (≥60 years) with treatment-resistant depression who relapsed after remission or did not remit in the RCT were administered an open-label phase...
June 13, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28734173/reliability-and-validity-of-the-tilburg-frailty-indicator-tfi-among-chinese-community-dwelling-older-people
#2
Lijuan Dong, Na Liu, Xiaoyu Tian, Xiaoxia Qiao, Robbert J J Gobbens, Robert L Kane, Cuili Wang
OBJECTIVE: To translate the Tilburg Frailty Indicator (TFI) into Chinese and assess its reliability and validity. METHODS: A sample of 917 community-dwelling older people, aged ≥60 years, in a Chinese city was included between August 2015 and March 2016. Construct validity was assessed using alternative measures corresponding to the TFI items, including self-rated health status (SRH), unintentional weight loss, walking speed, timed-up-and-go tests (TUGT), making telephone calls, grip strength, exhaustion, Short Portable Mental Status Questionnaire (SPMSQ), Geriatric Depression scale (GDS-15), emotional role, Adaptability Partnership Growth Affection and Resolve scale (APGAR) and Social Support Rating Scale (SSRS)...
July 15, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28731429/severity-of-depression-impacts-imminent-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease
#3
Michaela Defrancesco, Josef Marksteiner, Georg Kemmler, Walter Wolfgang Fleischhacker, Imrich Blasko, Eberhard A Deisenhammer
BACKGROUND: Mild cognitive impairment (MCI) has been suggested to represent a prodromal stage of dementia and to confer a high risk for conversion to dementia Alzheimer's type (DAT). OBJECTIVES: In this study, we examined the predictive value of depressive symptoms and neuropsychological variables on conversion of MCI to DAT. METHODS: Neuropsychological and clinical follow-up data of 260 MCI patients seen at the Psychiatric Memory Clinic of the Medical University of Innsbruck between 2005 and 2015 were analyzed retrospectively...
July 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28728617/self-reported-sleep-quality-duration-and-health-related-quality-of-life-in-older-chinese-evidence-from-a-rural-town-in-suzhou-china
#4
Chen-Wei Pan, Xiaoling Cong, Hui-Jun Zhou, Jing Li, Hong-Peng Sun, Yong Xu, Pei Wang
STUDY OBJECTIVES: To determine the associations of self-reported sleep quality and duration with health-related quality of life (HRQOL) in older Chinese. METHODS: We analyzed community-based cross-sectional data of 5,539 individuals aged 60 years and older in the Weitang Geriatric Disease Study. Information of sleep quality and duration were self-reported through participants' responses to predefined questions; HRQOL data were collected by using the European Quality of Life-5 Dimensions (EQ-5D)...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28727796/effects-of-health-risk-assessment-and-counselling-on-physical-activity-in-older-people-a-pragmatic-randomised-trial
#5
Anna Marie Herghelegiu, André Moser, Gabriel Ioan Prada, Stephan Born, Matthias Wilhelm, Andreas E Stuck
BACKGROUND: Interventions to increase physical activity (PA) among older community-dwelling adults may be enhanced by using multidimensional health risk assessment (HRA) as a basis for PA counselling. METHODS: The study was conducted among nondisabled but mostly frail persons 65 years of age and older at an ambulatory geriatric clinic in Bucharest, Romania. From May to July 2014, 200 participants were randomly allocated to intervention and control groups. Intervention group participants completed an initial HRA questionnaire and then had monthly counselling sessions with a geriatrician over a period of six months that were aimed at increasing low or maintaining higher PA...
2017: PloS One
https://www.readbyqxmd.com/read/28721433/oral-health-and-the-frail-elderly
#6
L Rapp, S Sourdet, B Vellas, M-H Lacoste-Ferré
INTRODUCTION: The relationships between oral health conditions and frailty have rarely been explored. A systematic review of frailty components and oral health concluded that differences in study population endpoint criteria and study design cannot establish a relationship between frailty and oral health. OBJECTIVE: This study aims to describe the distribution of the OHAT (Oral Health Assessment Tool) score in a population of frail subjects and to assess associated parameters (age, socio-economic status, living conditions, education level, nutritional habits, cognitive functioning, autonomy)...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28721431/depressive-symptoms-falls-and-fear-of-falling-in-old-korean-adults-the-korean-longitudinal-study-on-health-and-aging-klosha
#7
Y Park, N-J Paik, K W Kim, H-C Jang, J-Y Lim
Fall is a common cause of disability and death in old adults, and much research has been focused on identifying risk factors and developing preventive measures. Yet the majority of preceding research has been focused on physical performance. This study aims to evaluate the association between fall and depressive symptoms in community-dwelling elderly. Cross-sectional data of 431 men and 546 women was collected from old Korean adults living in Seongnam, Korea. Geriatric fall assessment was conducted by self-report questionnaires...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28716256/post-stroke-depression-in-ghana-characteristics-and-correlates
#8
Fred Stephen Sarfo, Carolyn Jenkins, Arti Singh, Mayowa Owolabi, Akin Ojagbemi, Nathaniel Adusei, Raelle Saulson, Bruce Ovbiagele
BACKGROUND: Poststroke depression (PSD) is prevalent and is an important determinant of functional recovery, quality of life and mortality after stroke. Scanty data on the nature of PSD among stroke survivors in sub-Saharan Africa prompted this study. OBJECTIVE: To assess the prevalence and predictors of depression in a convenience sample of Ghanaian stroke survivors. METHODS: We evaluated consecutive stroke survivors encountered at a comprehensive neurology clinic in a tertiary medical center in Ghana...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28712980/association-of-selective-serotonin-reuptake-inhibitors-and-bone-mineral-density-in-elderly-women
#9
Smita Saraykar, Vineeth John, Bo Cao, Matthew Hnatow, Catherine G Ambrose, Nahid Rianon
Depression and osteoporosis are 2 common comorbidities in geriatric patients. There are concerns about the deleterious effects of selective serotonin reuptake inhibitor (SSRI) antidepressant use on bone mineral density (BMD). We examined the association between SSRI use and BMD in elderly women (≥65 yr) referred to a geriatric osteoporosis clinic for bone health evaluation. Cross-sectional analyses using the general linear model were performed on data collected retrospectively from August 2010 to April 2015...
July 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28712623/valid-outcome-measures-in-care-for-older-people-comparing-the-ascot-and-the-icecap-o
#10
COMPARATIVE STUDY
Mariska Q N Hackert, Job van Exel, Werner B F Brouwer
BACKGROUND: Limited health care budgets and population aging result in a need to compare care services on their benefits and costs. Because services for older people often aim to improve multiple life aspects, valid measures are needed to examine their benefits on individuals' health and well-being simultaneously. Two measures may meet this end: the Adult Social Care Outcomes Toolkit (ASCOT) and the ICEpop CAPability measure for Older people (ICECAP-O). OBJECTIVES: To compare the validity of both measures, the ASCOT and the ICECAP-O...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28711192/predictors-of-anxiety-in-early-stage-parkinson-s-disease-results-from-the-first-two-years-of-a-prospective-cohort-study
#11
Sonja Rutten, Peter M van der Ven, Daniel Weintraub, Gregory M Pontone, Albert F G Leentjens, Henk W Berendse, Ysbrand D van der Werf, Odile A van den Heuvel
AIM: Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD. METHODS: The participants of this two-year prospective cohort study were recently diagnosed PD patients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline...
July 5, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28705225/the-impact-of-social-engagement-on-health-related-quality-of-life-and-depressive-symptoms-in-old-age-evidence-from-a-multicenter-prospective-cohort-study-in-germany
#12
André Hajek, Christian Brettschneider, Tina Mallon, Annette Ernst, Silke Mamone, Birgitt Wiese, Siegfried Weyerer, Jochen Werle, Michael Pentzek, Angela Fuchs, Janine Stein, Tobias Luck, Horst Bickel, Dagmar Weeg, Michael Wagner, Kathrin Heser, Wolfgang Maier, Martin Scherer, Steffi G Riedel-Heller, Hans-Helmut König
BACKGROUND: Thus far, only a few longitudinal studies investigated the impact of social engagement on health-related quality of life (HRQoL) and depressive symptoms in old age. Therefore, we aimed to examine the impact of social engagement on HRQoL and depressive symptoms in late life. METHODS: Individuals aged 75 years and over at baseline were interviewed every 1.5 years in a multicenter prospective cohort study in Germany. While HRQoL was quantified by using the Visual Analogue Scale (EQ VAS) of the EQ-5D instrument, depressive symptoms was assessed by using the Geriatric Depression Scale (GDS)...
July 14, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28699992/changes-in-frailty-conditions-and-phenotype-components-in-elderly-after-hospitalization
#13
Gianna Fiori Marchiori, Darlene Mara Dos Santos Tavares
Objective: describing the changes in frailty conditions over the period of a year after hospital discharge, verifying predictive variables for changes in frailty conditions and frailty phenotype components according to worsening, improving and stable groups. Method: a longitudinal survey carried out with 129 elderly. A structured form for socioeconomic and health data, scales (Geriatric Depression Scale - short form, Katz scale, Lawton and Brody scale) and frailty phenotype according to Fried were used...
July 10, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28697559/depressive-symptoms-and-tau-accumulation-in-the-inferior-temporal-lobe-and-entorhinal-cortex-in-cognitively-normal-older-adults-a-pilot-study
#14
Jennifer R Gatchel, Nancy J Donovan, Joseph J Locascio, Aaron P Schultz, J Alex Becker, Jasmeer Chhatwal, Kathryn V Papp, Rebecca E Amariglio, Dorene M Rentz, Deborah Blacker, Reisa A Sperling, Keith A Johnson, Gad A Marshall
BACKGROUND: Depressive symptoms are common in older adults and associated with increased morbidity and cognitive decline. These symptoms occur during preclinical and prodromal stages of Alzheimer's disease (AD), but their relationship to tau, one of the main AD proteinopathies, is poorly understood. OBJECTIVE: The objective of this study was to investigate the cross-sectional association between depressive symptoms and cerebral tau [18F T807 (also known as 18F-AV-1451) tau positron emission tomography (PET) imaging] in cognitively normal (CN) older adults...
July 4, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28697555/subjective-cognitive-complaints-in-cognitively-healthy-older-adults-and-their-relationship-to-cognitive-performance-and-depressive-symptoms
#15
Hana Markova, Ross Andel, Hana Stepankova, Miloslav Kopecek, Tomas Nikolai, Jakub Hort, Catherine Thomas-Antérion, Martin Vyhnalek
BACKGROUND: Subjective cognitive complaints (SCCs) may be an early marker of prodromal Alzheimer's disease. OBJECTIVES: Using a 10-item yes/no SCCs questionnaire (Le Questionnaire de Plainte Cognitive [QPC]), we evaluated the prevalence and distribution of SCCs in cognitively healthy Czech older adults and examined total score and specific QPC items in relation to depressive symptomology and cognitive performance. METHODS: A sample of 340 cognitively healthy older community-dwelling volunteers aged 60 or older from the third wave of the longitudinal project National Normative Study of Cognitive Determinants of Healthy Aging, who underwent a comprehensive neuropsychological assessment and completed the QPC and the 15-item Geriatric Depression Scale (GDS-15)...
July 4, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28691530/depressive-symptoms-in-parkinson-s-disease-are-related-to-decreased-left-hippocampal-volume-correlation-with-the-15-item-shortened-version-of-the-geriatric-depression-scale
#16
Masami Goto, Koji Kamagata, Taku Hatano, Nobutaka Hattori, Osamu Abe, Shigeki Aoki, Masaaki Hori, Tsutomu Gomi
Background The relationship between hippocampal and amygdaloid volumes and depression in patients with Parkinson's disease (PD) is a controversial issue. Purpose To investigate the correlation between the 15-item shortened version of the Geriatric Depression Scale (GDS-15) and gray matter volume in PD. Material and Methods In the present study, 46 participants with PD were scanned with 3 T magnetic resonance imaging (MRI) to obtain three-dimensional (3D) T1-weighted (T1W) images. Neurologists specializing in movement disorders performed clinical evaluations of the participants (e...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28691515/anxiety-age-education-and-activities-of-daily-living-as-predictive-factors-of-the-occurrence-of-frailty-syndrome-in-patients-with-heart-rhythm-disorders
#17
Agnieszka Mlynarska, Rafal Mlynarski, Krzysztof S Golba
OBJECTIVES: Frailty is one of the geriatric syndromes that are caused by subclinical impairment of many organs, leading to the loss of reserves and the ability to maintain homeostasis. Aim of the study was to assess which factors including anxiety and depression can be predictive factors for the occurrence of frailty syndrome in patients with heart rhythm disorders. METHODS: The study included 171 consecutive patients >64 years (73.91 ± 6.72; 48.5% W) with diagnosed cardiac arrhythmias who had been qualified for pacemaker implantation...
July 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28689570/rapid-depression-assessment-in-geriatric-patients
#18
REVIEW
George T Grossberg, David Beck, Syed Noman Y Zaidi
Depression is common in geriatric patients, especially in those with multiple comorbidities and polypharmacy. Depression in older adults is often underdiagnosed and undertreated. Initial screening for depression can easily be accomplished in the waiting room. Yet the clinical interview still remains the gold standard for diagnosing geriatric depression. Key components of the clinical interview are observant watching of the patient for the subtle signs of depression. Clinical interview should be done with sensitivity to the importance of privacy...
August 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/28689109/organophosphate-pesticides-and-pon1-l55m-in-parkinson-s-disease-progression
#19
Kimberly C Paul, Janet S Sinsheimer, Myles Cockburn, Jeff M Bronstein, Yvette Bordelon, Beate Ritz
BACKGROUND: Parkinson's disease (PD) has motor and non-motor features that contribute to its phenotype and functional decline. Organophosphate (OP) pesticides and PON1 L55M, which influences OP metabolism, have been implicated in multiple mechanisms related to neuronal cell death and may influence PD symptom progression. OBJECTIVE: To investigate whether ambient agricultural OP exposure and PON1 L55M influence the rate of motor, cognitive, and mood-related symptom progression in PD...
July 6, 2017: Environment International
https://www.readbyqxmd.com/read/28682136/associations-between-the-dimensions-of-perceived-togetherness-loneliness-and-depressive-symptoms-among-older-finnish-people
#20
Katja Pynnönen, Taina Rantanen, Katja Kokko, Pirjo Tiikkainen, Mauri Kallinen, Timo Törmäkangas
OBJECTIVES: We studied the associations between perceived togetherness, depressive symptoms, and loneliness over a six-month period among 222 people aged 75-79 who reported loneliness or depressive mood at baseline. METHOD: The present cross-lagged models utilized baseline and six-month follow-up data of a randomized controlled trial that examined the effects of a social intervention on loneliness and depression (ISRCTN78426775). Dimensions of perceived togetherness, i...
July 6, 2017: Aging & Mental Health
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