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Modified ultrafiltration

Eleonora Veglia, Alessandro Pini, Aldo Moggio, Cristina Grange, Federica Premoselli, Gianluca Miglio, Katerina Tiligada, Roberto Fantozzi, Paul L Chazot, Arianna Carolina Rosa
Histamine has been reported to decrease the ultrafiltration coefficient, which inversely correlates with glomerular permselectivity, however the mechanism(s) underling this effect have never been investigated. This study aimed to assess whether histamine could exert a direct detrimental effect on podocyte permeability and the possible involvement of two key proteins for the glomerular slit diaphragm (SD) integrity, zonula occludens-1 (ZO-1) and P-cadherin. The effect of histamine (100 pM-1000nM) on coloured podocytes junctional integrity was evaluated functionally by a transwell assay of monolayer permeability and morphologically by electron microscopy...
October 14, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Nathaniel Charles Wardrip, Melissa Dsouza, Meltem Urgun-Demirtas, Seth W Snyder, Jack A Gilbert, Christopher J Arnusch
Understanding and restricting microbial surface attachment will enhance wastewater treatment with membranes. We report a maskless lithographic patterning technique for the generation of patterned polymer coatings on ultrafiltration membranes. Polyethylene glycol, zwitterionic, or negatively charged hydrophilic polymer compositions in parallel- or perpendicular-striped patterns with respect to feed flow were evaluated using wastewater. Membrane fouling was dependent on the orientation and the chemical composition of the coatings...
October 17, 2016: ACS Applied Materials & Interfaces
Richard A Jonas
No abstract text is available yet for this article.
October 5, 2016: Perfusion
Craig M McRobb, Richard J Ing, D Scott Lawson, James Jaggers, Mark Twite
Modified ultrafiltration (MUF) is a technique which is commonly used immediately post-cardiopulmonary bypass (CPB) for open heart surgery in children. There are many advantages of MUF, but there are also a number of less reported disadvantages. At our institution, after considering all of the available data, a decision was made to no longer perform MUF. The primary motivation being the simplified and miniaturized CPB circuit would reduce hemodilution, decrease our likelihood of reaching our transfusion trigger during CPB and, potentially, improve safety...
October 5, 2016: Perfusion
Hesamoddin Rabiee, S Mojtaba Seyedi, Hossein Rabiei, Negar Alvandifar
Two non-ionic and hydrophilic surfactant additives, Tetronic-1107 and Triton X-100, were added to poly(vinyl chloride)/NMP polymeric solution to prepare ultrafiltration membranes via immersion precipitation. Surfactants at three different weight percentages up to 6 wt% were added, and the fabricated membranes were characterized and their performance for water treatment in the presence of bovine serum albumin (BSA) as a foulant was assessed. The scanning electron microscopy images indicated remarkable changes in morphology due to higher thermodynamic instability after surfactant addition...
September 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
H Cheraghi Bidsorkhi, H Riazi, D Emadzadeh, M Ghanbari, T Matsuura, W J Lau, A F Ismail
In this research, novel ultrafiltration nanocomposite membranes were prepared by incorporating self-synthesized nanoporous titanium dioxide (NTiO2) nanoparticles into polysulfone. The surface of the nanoparticle was treated with a silane-based modifier to improve its distribution in the host polymer. Atomic-force microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, Brunauer-Emmett-Teller, transmission electron microscopy, energy-dispersive x-ray spectroscopy, porosity and contact angle tests were conducted to characterize the properties of the particles as well as the fabricated nanocomposite membranes...
October 14, 2016: Nanotechnology
Jingchun Li, Xuyang Liu, Jiaqi Lu, Yudan Wang, Guanglu Li, Fangbo Zhao
To improve the anti-biofouling properties of PVDF membranes, GO-Ag composites were synthesized and used as membrane antibacterial agent by a simple and environmentally friendly method. As identified by XRD, TEM and FTIR analysis, AgNPs were uniformly assembled on the synthesized GO-Ag sheets. The membranes were prepared by phase inversion method with different additional amounts (0.00-0.15wt%) of GO-Ag composites. The GO-Ag composites modified membranes show improved hydrophilicity, mechanical property and permeability than unmodified PVDF membrane...
December 15, 2016: Journal of Colloid and Interface Science
Marie Hoarau, Yannick Malbert, Romain Irague, Christelle Hureau, Peter Faller, Emmanuel Gras, Isabelle André, Magali Remaud-Siméon
An improved production and purification method for Alzheimer's disease related methionine-modified amyloid-β 1-40 and 1-42 peptides is proposed, taking advantage of the formation of inclusion body in Escherichia coli. A Thioflavin-S assay was set-up to evaluate inclusion body formation during growth and optimize culture conditions for amyloid-β peptides production. A simple and fast purification protocol including first the isolation of the inclusion bodies and second, two cycles of high pH denaturation/ neutralization combined with an ultrafiltration step on 30-kDa cut-off membrane was established...
2016: PloS One
Jennifer E Flythe
Mounting evidence supports a strong association between fluid management and outcomes among individuals receiving maintenance hemodialysis. The speed of fluid removal during dialysis (ultrafiltration, UF) is a modifiable aspect of fluid management that has attracted recent attention as a potential performance measure for facility fluid management practices. Observational data support an association between higher UF rates and adverse outcomes. This association is supported by the plausible pathophysiologic rationale of hypoperfusion-induced ischemic injury to the heart and other end-organs...
August 16, 2016: Seminars in Dialysis
Viktoriia Konovalova, Kateryna Guzikevich, Anatoliy Burban, Wojciech Kujawski, Karolina Jarzynka, Joanna Kujawa
In order to prepare ultrafiltration membranes possessing biocatalytic properties, α-amylase has been immobilized on cellulose membranes. Enzyme immobilization was based on a covalent bonding between chitosan and a surface of cellulose membrane, followed by an attachment of Cibacron Blue F3G-A dye as affinity ligand. Various factors affecting the immobilization process, such as enzyme concentration, pH of modifying solution, zeta-potential of membrane surface, and stability of immobilized enzyme were studied...
November 5, 2016: Carbohydrate Polymers
J A Prince, S Bhuvana, V Anbharasi, N Ayyanar, K V K Boodhoo, G Singh
Oil pollution in water and separation of oil from water are receiving much attention in recent years due to the growing environmental concerns. Membrane technology is one of the emerging solutions for oil-water separation. However, there is a limitation in using polymeric membrane for oil water separation due to its surface properties (wetting behaviour), thermal and mechanical properties. Here, we have shown a simple method to increase the hydrophilicity of the polyethersulfone (PES) hollow fibre ultrafiltration (UF) membrane by using carboxyl, hydroxyl and amine modified graphene attached poly acrylonitrile-co-maleimide (G-PANCMI)...
October 15, 2016: Water Research
Herb Lutz, Joshua Arias, Yu Zou
High therapeutic dosage requirements and the desire for ease of administration drive the trend to subcutaneous administration using delivery systems such as subcutaneous pumps and prefilled syringes. Because of dosage volume limits, prefilled syringe administration requires higher concentration liquid formulations, limited to about 30 cP or roughly 100-300 g L(-1) for mAb's. Ultrafiltration (UF) processes are routinely used to formulate biological therapeutics. This article considers pressure constraints on the UF process that may limit its ability to achieve high final product concentrations...
July 25, 2016: Biotechnology Progress
Holly Kramer, Jerry Yee, Daniel E Weiner, Vinod Bansal, Michael J Choi, Laura Brereton, Jeffrey S Berns, Milagros Samaniego-Picota, Paul Scheel, Michael Rocco
High hemodialysis ultrafiltration rate (UFR) is increasingly recognized as an important and modifiable risk factor for mortality among patients receiving maintenance hemodialysis. Recently, the Kidney Care Quality Alliance (KCQA) developed a UFR measure to assess dialysis unit care quality. The UFR measure was defined as UFR≥13mL/kg/h for patients with dialysis session length less than 240 minutes and was endorsed by the National Quality Forum as a quality measure in December 2015. Despite this, implementation of a UFR threshold remains controversial...
October 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Yuanyuan Zhao, Jiaqi Lu, Xuyang Liu, Yudan Wang, Jiuyang Lin, Na Peng, Jingchun Li, Fangbo Zhao
A novel polyvinyl chloride (PVC) membrane was modified with graphene oxide (GO) via phase inversion method to improve its hydrophilicity and mechanical properties. The GO presented a large amount of hydrophilic groups after the modification through the modified Hummers method. It was observed that with the addition of low fraction of GO powder, the GO/PVC hybrid membranes exhibited a significant enhancement in hydrophilicity, water flux, and mechanical properties. With optimal dosage (0.1wt%), the pure water flux of GO/PVC membrane increased from 232...
October 15, 2016: Journal of Colloid and Interface Science
Danish Naveed, Riaz Anwar Khan, Abdul Malik, Syed Zahid Ali Shah, Ikram Ullah, Amjad Hussain
BACKGROUND: Cardiopulmonary bypass (CPB) is associated with morbidity and mortality. To reduce its adverse effect modified ultrafiltration is being increasingly employed. This study is planned to evaluate the benefits of modified ultrafiltration (MUF) in adult cardiac surgery. METHODS: Eighty consecutive patients presenting to adult cardiac surgery as elective case were enrolled. These patients were randomly divided in to two groups. MUF group which received modified ultrafiltration after separation from CPB and control group which did not receive modified ultrafiltration...
January 2016: Journal of Ayub Medical College, Abbottabad: JAMC
Leyat Tal, Joseph R Angelo, Ayse Akcan-Arikan
Peritoneal dialysis (PD) is generally considered the preferred extracorporeal therapy for neonates with acute kidney injury (AKI). However, there are situations when PD is not suitable, such as in patients with previous abdominal surgery, hyperammonemia and significant ascites or anasarca. Additionally, with a need to start PD soon after catheter placement, there is increased risk of PD catheter leak and infection. Extracorporeal continuous renal replacement therapy (CRRT) is challenging in severely ill neonates as it requires obtaining adequately sized central venous access to accommodate adequate blood flow rates and also adaptation of a CRRT machine meant for older children and adults...
November 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
I M Habibullin, P I Mironov, D V Onegov, R I Zaripova, I E Nikolaeva
UNLABELLED: In children during the first months of life delayed sternum closure is one of the few techniques increasing cardiac output after simultaneous correction of complex congenital heart defects (CHD). The aim of study was evaluating mortality, predictors of adverse outcome and frequency noncardial complications at of delayed sternum closure after correction of CHD. METHODS: Study design: a prospective, uncontrolled, cohort. 22 children were studied 6 children died...
January 2016: Anesteziologiia i Reanimatologiia
James R Neal, Caitlin L Blau, Amanda M Cornelius, Roxann B Pike, Joseph A Dearani, Bassem N Mora
Patients needing the assistance of extracorporeal membrane oxygenation (ECMO) are at risk of hemodilution and, in some instances, may require exposure to large amounts of allogeneic blood products. Patient outcomes can be improved by taking steps to reduce transfusions and hemodilution. Currently, modified ultrafiltration (MUF) is used across the world to reduce hemodilution after cardiopulmonary bypass (CPB). Another common technique during bypass initiation is autologous priming. By applying modified versions of these techniques, ECMO patients may potentially benefit...
March 2016: Journal of Extra-corporeal Technology
Joseph G Timpa, L Carlisle O'Meara, Kellen G Goldberg, Jay P Phillips, Jack H Crawford, Kimberly W Jackson, Jeffrey A Alten
Perioperative transfusion of blood products is associated with increased morbidity and mortality after pediatric cardiac surgery. We report the results of a quality improvement project aimed at decreasing perioperative blood product administration and bleeding after pediatric cardiopulmonary bypass (CPB) surgery. A multidisciplinary team evaluated baseline data from 99 consecutive CPB patients, focusing on the variability in transfusion management and bleeding outcomes, to create a standardized bleeding and transfusion management protocol...
March 2016: Journal of Extra-corporeal Technology
Yutaka Koda, Ikuo Aoike, Shin Hasegawa, Yutaka Osawa, Yoichi Nakagawa, Fumio Iwabuchi, Chikara Iwahashi, Tokuichiro Sugimoto, Toshihiko Kikutani
BACKGROUND: Intradialytic hypotension (IDH) is one of the major problems in performing safe hemodialysis (HD). As blood volume depletion by fluid removal is a major cause of hypotension, careful regulation of blood volume change is fundamental. This study examined the effect of intermittent back-filtrate infusion hemodiafiltration (I-HDF), which modifies infusion and ultrafiltration pattern. METHODS: Purified on-line quality dialysate was intermittently infused by back filtration through the dialysis membrane with a programmed dialysis machine...
April 28, 2016: Clinical and Experimental Nephrology
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