Jun Luo, Boyue Zhang, Yuting Wu, Qin Tian, Meijun Mo, Teng Long, Mingzhu Mei, Ruqi Fan, Ziyu Lyu, He Jiang, Fan Wu, Yingyi Lin, Xiaofeng Guo
Rabies, which is caused by the rabies virus (RABV), is an ancient zoonosis that has a high mortality rate. Previous studies have indicated that recombinant RABV expressing canine interleukin-6 (rHEP-CaIL6), induced more virus-neutralizing antibodies than parental RABV in mice following intramuscular immunization. To investigate the immune response induced in the CNS by rHEP-CaIL6 after intranasal or intracranial administration in mice, the permeability of the blood-brain barrier (BBB), the infiltration of CD3 T cells, and innate immune response-related effector molecules in the CNS were examined...
July 2018: Archives of Virology