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Pharmacology otolaryngology

Angie C Jelin, Elizabeth O'Hare, Karin Blakemore, Eric B Jelin, David Valle, Julie Hoover-Fong
Skeletal dysplasias represent a large and diverse group of rare conditions affecting collagen and bone. They can be clinically classified based on radiographic and physical features, and many can be further defined at a molecular level (Bonafe et al., 2015). Early diagnosis is critical to proper medical management including pharmacologic treatment when available. Patients with severe skeletal dysplasias often have small chests with respiratory insufficiency or airway obstruction and require immediate intubation after birth...
2017: Frontiers in Pharmacology
L Stepan, C-K L Shaw, S Oue
BACKGROUND: Temporomandibular disorder poses a diagnostic challenge to otolaryngologists as orofacial pain, headache and otology symptoms are very common in temporomandibular disorder, and mimic a number of otolaryngological conditions. Missed diagnosis of temporomandibular disorder can lead to unnecessary investigation and treatment, resulting in further patient suffering. OBJECTIVES: To review the current literature and propose management pathways for otolaryngologists to correctly differentiate temporomandibular disorder from other otolaryngological conditions, and to initiate effective treatment for temporomandibular disorder in collaboration with other health professionals...
January 2017: Journal of Laryngology and Otology
Maria Claudia Rodríguez, Perla Villamor, Tatiana Castillo
INTRODUCTION: Pain is a disease by itself and it's a public health concern of major implication in children, not just because of the emotional component of the child and his family, but also due to the potential morbidity and mortality involving it. A proper assessment of pain it's a challenge in the pediatric population, due to their lack of understanding and verbalization of hurt. Additionally, a satisfactory treatment of pediatric pain can be arduous due to a lack of clinical knowledge, insufficient pediatric research, and the fear to opioid side effects and addiction...
November 2016: International Journal of Pediatric Otorhinolaryngology
Jarosłąw Woroń, Barbara Lorkowska-Zawicka, Elżbieta Dobrowolska, Wojciech Serednicki
Drug interactions are a growing problem in the practice of otolaryngology. The use of drugs in patients treated with polypharmacy generates the risk of adverse drug interactions which requires specialized knowledge and active prevention. The most common interactions encountered by ENT physicians are identified on the basis of the analysis of medical order sheets and discussed in the article.
May 24, 2016: Otolaryngologia Polska
Rudolf Reiter, Thomas Karl Hoffmann, Anja Pickhard, Sibylle Brosch
BACKGROUND: Hoarseness (dysphonia) is the reason for about 1% of all consultations in primary care. It has many causes, ranging from self-limited laryngitis to malignant tumors of the vocal cords. METHODS: This review is based on literature retrieved by a selective search in PubMed employing the terms "hoarseness," "hoarse voice," and "dysphonia," on the relevant guideline of the American Academy of Otolaryngology -Head and Neck Surgery, and on Cochrane reviews...
May 8, 2015: Deutsches Ärzteblatt International
Sumanth Kumbargere Nagraj, Shetty Naresh, Kandula Srinivas, P Renjith George, Ashish Shrestha, David Levenson, Debra M Ferraiolo
BACKGROUND: The sense of taste is very much essential to the overall health of the individual. It is a necessary component to enjoying one's food, which in turn provides nutrition to an individual. Any disturbance in taste perception can hamper the quality of life in such patients by influencing their appetite, body weight and psychological well-being. Taste disorders have been treated using different modalities of treatment and there is no consensus for the best intervention. Hence this Cochrane systematic review was undertaken...
2014: Cochrane Database of Systematic Reviews
Sarah J Blank, David J Grindler, Janice Zerega, Morey Blinder, Brian Nussenbaum
OBJECTIVES: To describe a population of otolaryngology patients who developed systemic anticoagulation from pharmacologic deep vein thrombosis prophylaxis using subcutaneous low-dose unfractionated heparin and describe associated adverse events and identify risk factors for this occurrence. STUDY DESIGN: Retrospective case series with chart review. SETTING: Single-institution, academic tertiary care center. SUBJECTS AND METHODS: Patients who developed prolonged partial thromboplastin times from routine administration of subcutaneous low-dose unfractionated heparin postoperatively were retrospectively identified during a 16-month period...
December 2014: Otolaryngology—Head and Neck Surgery
Christian Chabbert
Recent epidemiological investigations have highlighted the high prevalence of vestibular dysfunctions in the adult population and its association with aging. Despite a large and unmet medical need, the pharmaceutical options of targeted and efficient drugs to reduce the symptoms associated with vestibular deficits remains largely insufficient. This special issue of the Journal of Vestibular Research is devoted to the session: New insights on vestibular neuropharmacology: From bench to bedside, that was organized at the 2012 Midwinter Meeting of the Association of Research in Otolaryngology...
2013: Journal of Vestibular Research: Equilibrium & Orientation
Alessandro De Stefano, Francesco Dispenza, Hamlet Suarez, Nicolas Perez-Fernandez, Raquel Manrique-Huarte, Jae Ho Ban, Min-Beom Kim, Min Beom Kim, Michael Strupp, Katharina Feil, Carlos A Oliveira, Andres L Sampaio, Mercedes F S Araujo, Fayez Bahmad, Mauricio M Ganança, Fernando F Ganança, Ricardo Dorigueto, Hyung Lee, Gautham Kulamarva, Navneet Mathur, Pamela Di Giovanni, Anna Grazia Petrucci, Tommaso Staniscia, Leonardo Citraro, Adelchi Croce
OBJECTIVE: Primary objective of this study was to find a statistical link between the most worldwide comorbidities affecting the elderly population (hypertension, diabetes, osteoarthrosis, osteoporosis and depression) and recurrent episodes of BPPV. Secondary objective was defining possible "groups of risk" for people suffering recurrent positional vertigo related to the presence of a well documented comorbidity. METHODS: This was an observational, cross-sectional, multicenter, spontaneous, non-pharmacological study...
February 2014: Auris, Nasus, Larynx
D Monzani, M R Barillari, M Alicandri Ciufelli, E Aggazzotti Cavazza, V Neri, L Presutti, E Genovese
Despite an abundance of long-term pharmacological treatments for recurrent vertigo attacks due to Ménière's disease, there is no general agreement on the their efficacy. We present the results of a retrospective study based on a 10-year experience with two long-term medical protocols prescribed to patients affected by Ménière's disease (diagnosed according to the American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium guidelines) who completed treatments in the period 1999-2009...
December 2012: Acta Otorhinolaryngologica Italica
Alison M Boyce, McKinley Glover, Marilyn H Kelly, Beth A Brillante, John A Butman, Edmond J Fitzgibbon, Carmen C Brewer, Christopher K Zalewski, Carolee M Cutler Peck, H Jeffrey Kim, Michael T Collins
CONTEXT: GH excess is a serious complication of McCune-Albright syndrome (MAS) and has been associated with craniofacial morbidity. OBJECTIVE: The aim of the study was to determine whether early diagnosis and treatment of MAS-associated GH excess prevents optic neuropathy and hearing impairment, the major morbidities associated with GH excess. DESIGN AND SETTING: A retrospective cross-sectional analysis was conducted at a clinical research center...
January 2013: Journal of Clinical Endocrinology and Metabolism
Wojciech Gawęcki, Witold Szyfter, Joanna Lączkowska-Przybylska, Joanna Szyfter-Harris
OBJECTIVE: To estimate the results of treatment of Ménière's disease with intratympanic injections of gentamicin. MATERIAL: 37 patients with defined, pharmacological treatment resistant Ménière's disease treated in Department of Otolaryngology and Laryngological Oncology of University of Medical Sciences in Poznań with intratympanic injections of gentamicin from 2001 to 2010 year. METHODS: Patients were injected intratympanic with 0.3 ml (12 mg) of gentamicin once or few times with 7 days or longer breaks and a number of injections depended on the reaction of the inner ear...
January 2012: Otolaryngologia Polska
Jarosław Miłoński, Piotr Pietkiewicz, Jurek Olszewski
INTRODUCTION: The aim of the study was to evaluate the results and 4-year own experience in the endoscopic treatment of the nose and paranasal sinuses. MATERIAL AND METHODS: In the Clinic of Otolaryngology and Laryngological Oncology of the Medical University of Lodz between 2006 and 2009 there were 603 endoscopic operations performed on patients with chronic paranasal sinusitis, including 287 females aged 17-80 and 316 males aged 18-87. The patients were qualified for the operation on the basis of an interview, objective otorhinolaryngological examination, frontal and transverse computerized tomography of the nose and paranasal sinuses, laboratory tests (blood cell count, sedimentation tests, urine tests, electrolytes tests)...
January 2011: Otolaryngologia Polska
Marcela Fandiño, Mary Connolly, Laurie Usher, Sheryl Palm, Frederick K Kozak
OBJECTIVE: To describe the clinical presentation and treatment of 3 children with an Auditory Processing Disorder with an identifiable neurological cause: Landau-Kleffner syndrome. This classical syndrome is well recognized in pediatric neurology but the diagnosis is less well known to Pediatric Otolaryngology, Speech Language Pathology and Audiology services. METHODS: Retrospective chart review of three patients with Landau-Kleffner syndrome. RESULTS: In all cases, pharmacological intervention led to clinical and electroencephalographic improvement, but all patients had long-term difficulty with understanding sounds in a noisy environment...
January 2011: International Journal of Pediatric Otorhinolaryngology
C Kiese-Himmel
Globus sensation is a medially felt lump in the throat. It can be associated with a number of different diseases, but this symptom may also occur monosymptomatically as a somatoform disorder or as a secondary somatoform illness behavior. Globus sensation may be persistent or intermittent. Diagnosis requires close interdisciplinary cooperation, since the globus may be a symptom of anxiety, depression or personality disorders. Firstly, patients should undergo a thorough otolaryngological examination (including careful medical history taking), possibly in cooperation with other medical specialists...
June 2010: HNO
Greg M Thaera, Kay E Wellik, David M Barrs, Erika D Driver Dunckley, Dean M Wingerchuk, Bart M Demaerschalk
BACKGROUND: : Bell palsy is idiopathic peripheral facial weakness that typically resolves without severe clinical sequelae. Treatment with corticosteroids and antiviral drugs is often initiated to improve the likelihood of a favorable outcome. OBJECTIVE: : Are corticosteroid and antiviral medications effective in the treatment of Bell palsy? METHODS: : The objective was addressed through the development of a structured critically appraised topic...
March 2010: Neurologist
William P Innis, Timothy D Anderson
PURPOSE: The objective of this study is to present incidence of deep venous thrombosis and pulmonary embolism in otolaryngologic patients and make recommendations on appropriate thromboprophylaxis. METHODS: The methods used in this study are as follows: 5-year retrospective review in a tertiary care otolaryngology practice and computer-based search from 2000 to 2005. Cases were segregated into ambulatory vs inpatient procedures and malignant vs nonmalignant diagnoses...
July 2009: American Journal of Otolaryngology
Taryn Davids, Doron D Sommer, David Armstrong
PURPOSE: Laryngopharyngeal reflux (LPR) -- gastroesophageal reflux above the upper esophageal sphincter -- is a common problem encountered by otolaryngologists. Despite consensus guidelines, the presentation, diagnosis, and treatment remain controversial. We surveyed Canadian otolaryngologists to assess current perspectives. METHODS: Web-based questionnaires were e-mailed to 135 otolaryngologists. Respondents were categorized by subspecialty as head and neck (H&N) or non-H&N (rhinology, otology, laryngology, facial plastics, general and pediatric otolaryngology)...
April 2008: Journal of Otolaryngology—Head & Neck Surgery
Jayesh Doshi
Rhinitis medicamentosa (RM) is a drug induced non-allergic rhinitis associated with prolonged use of topical nasal decongestants. This review discusses the nasal mucosa microcirculation, basic pharmacology of topical decongestants and the theories of the pathophysiology of RM. Diagnostic problems are discussed in addition to the current opinion on how to treat RM.
May 2009: European Archives of Oto-rhino-laryngology
Marcin Jadczak, Piotr Rapiejko, Ireneusz Kantor, Kornel Szczygielski, Jacek Usowski, Jacek Piechocki, Dariusz Jurkiewicz
UNLABELLED: Treatment of idiopathic sudden hearing loss (SHL) is still a big problem for the otolaryngologists, due to the still unexplained etiopathogenesis of the illness. The aim of this study was to evaluate effectiveness of pharmacotherapy combined with the hyperbaric oxygen (HBO) in idiopathic sudden sensorineural hearing loss treatment. Patients who received HBO and medical treatment in the Department of Otolaryngology of Military Institute of Health Service and Warsaw Center for Hyperbaric Therapy and Wounds Treatment were studied...
2007: Otolaryngologia Polska
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