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Pharmacokinetics otolaryngology

Koji Kijima, Nobuo Sato, Tomokazu Koresawa, Jun Morita, Hiroyuki Hayashi, Shigeki Shibasaki, Tohru Kurosawa, Kyoichi Totsuka
In a phase IIb clinical study (dose-finding test, 450 mg dosing group: 150 mg t.i.d., 500 mg dosing group: 250 mg b.i.d., 900 mg dosing group: 300 mg t.i.d.) of tebipenem pivoxil (TBPM-PI) for treatment of otolaryngological infections in adults, TBPM concentrations in the patient plasma were quantified. The primary pharmacokinetic parameters such as ka, kel, Vd/F and Tlag were estimated by the Bayesian method and then the secondary pharmacokinetic parameters such as tmax, Cmax, t1/2 and AUC were calculated...
April 2009: Japanese Journal of Antibiotics
P Federspil et al.
In 1999 the following guidelines were elaborated by a consensus conference of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery with delegates of 10 further societies and complemented by a Delphi procedure. In 2002 and 2008 up-dates were performed by the members of the consensus conference, the chair of the study group of ENT infectiology of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery and the presidency of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery...
April 2009: HNO
Nobuo Sato, Koji Kijima, Tomokazu Koresawa, Nayu Mitomi, Jun Morita, Hisashi Suzuki, Hiroyuki Hayashi, Shigeki Shibasaki, Tohru Kurosawa, Kyoichi Totsuka
Tebipenem pivoxil (TBPM-PI, ME1211) has been under development as the world's first oral carbapenem for treatment of otolaryngological/respiratory infections caused by drug-resistant S. pneumoniae in pediatric patients. In order to treat these infections effectively, it is important to design optimal dosing regimens based on the pharmacokinetics/pharmacodynamics (PK/PD) relationships, which can be characterized by clarifying the pharmacokinetics of tebipenem (TBPM) in the pediatric population. We therefore performed an population pharmacokinetic analysis using plasma TBPM concentrations obtained from pediatric patients with otolaryngological infection or bacterial pneumonia (0...
2008: Drug Metabolism and Pharmacokinetics
S Donnadieu
There are many types of pain induced in otolaryngology, stemming from medical acts, sinus drainage, packing of the nasal fossae, or complex bandaging after cancer surgery. In patients with impaired communication abilities resulting from impaired speech, greater attention must be paid to induced pain, sometimes requiring the use of behavioral evaluation scales. Preventing this pain means organizing medical acts and painful treatments by attempting to group them and informing the patient that the caregiver is listening to him and relieving his pain...
October 2007: Annales D'oto-laryngologie et de Chirurgie Cervico Faciale
Zorik Spektor, Mark C Jasek, Dan Jasheway, David C Dahlin, David J Kay, Ron Mitchell, Robert Faulkner, G Michael Wall
OBJECTIVE: Describe the pharmacokinetics of ciprofloxacin and dexamethasone after administration of CIPRODEX Otic Suspension (CIP/DEX) into the middle ears of children. DESIGN: Open-label, single-dose, pharmacokinetic studies, administering four drops of CIP/DEX instilled into each middle ear through the tympanostomy tubes immediately following tube placement. Blood was collected for 6h and analyzed for ciprofloxacin and dexamethasone concentrations using a validated liquid chromatography and tandem mass spectrometry (LC/MS/MS) method...
January 2008: International Journal of Pediatric Otorhinolaryngology
Michael E Pichichero
The antibiotic preferences of 2,190 pediatricians (peds) 360 general practitioners (GPs), and 273 otolaryngologists (ENTs) in the United States and concurrence with treatment guideline recommendations for acute otitis media (AOM) for suspected drug-resistant Streptococcus pneumoniae (DRSP) and beta-lactamase-producing Haemophilus influenzae before and after an educational workshop were compared. Peds and GPs preferred amoxicillin/clavulanate high-dose, whereas ENTs preferred higher generation cephalosporins...
September 2005: Clinical Pediatrics
Frédérique S Servin, Bernard Bougeois, Roberto Gomeni, France Mentré, Robert Farinotti, Jean-Marie Desmonts
BACKGROUND: Chronic alcoholic patients are frequently presented for anesthesia and surgery. These patients require higher doses of propofol than control patients for induction of anesthesia, but whether this is because of changes in pharmacokinetics or pharmacodynamics is not known. This study was designed to investigate the influence of chronic ethanol intake on propofol pharmacokinetics. METHODS: Fifteen chronic alcoholic and 15 control patients, receiving propofol by target-controlled infusion for otolaryngologic surgery, were studied...
September 2003: Anesthesiology
R W Force, M C Hart, S A Plummer, D A Powell, M C Nahata
OBJECTIVE: To evaluate the efficacy, systemic absorption, and safety of ototopically administered ciprofloxacin in children with otorrhea associated with tympanostomy tube placement. DESIGN: Nonrandomized, open-label pilot trial with pharmacokinetic determination of the systemic absorption of ototopical ciprofloxacin. SETTING: A pediatric otolaryngology clinic affiliated with Columbus (Ohio) Children's Hospital. PATIENTS: Patients aged 3 to 8 years were enrolled if they had persistent otorrhea associated with tympanostomy tube placement...
August 1995: Archives of Otolaryngology—Head & Neck Surgery
L Saarnivaara, U M Kautto, E Iisalo, K Pihlajamäki
Pharmacokinetic and pharmacodynamic parameters of atropine 0.03 mg/kg p.o. or 0.02 mg/kg i.m. were compared in a double-blind study in 20 children with a mean age of 5.1 years undergoing otolaryngological surgery, mostly adenotomy. Outside the study protocol, two small children accidentally received an overdose of atropine 0.3 mg/kg p.o. In addition to atropine, all children received triclofos 70 mg/kg p.o. Following p.o. administration of atropine, the mean maximum serum concentration of 6.7 nmol/l occurred at 2 h...
July 1985: Acta Anaesthesiologica Scandinavica
K Sato
Coenzyme Q10 (CoQ10) has already been favorably evaluated in the clinical treatment of heart disease. In the otolaryngological field, it has been reported that CoQ10 is effective in promoting recovery from acute sudden deafness. However, the pharmakinetics of CoQ10 in the inner ear is not yet clarified. The present study focuses upon the pharmacokinetics of CoQ10 using guinea pigs with acute sensorineural hearing loss artificially induced by hypoxia conditions. The respiration of the animals was controlled in an artificial respirator while the ABR, ECG and blood pressure were monitored...
1988: Acta Oto-laryngologica. Supplementum
A Hiller, K T Olkkola, P Isohanni, L Saarnivaara
An 8-yr-old boy suffering from an asymptomatic ventricular septal defect was given erythromycin for antibiotic prophylaxis before adenoidectomy. Sixty minutes after premedication with oral midazolam 0.5 mg kg-1 and oral atropine 0.03 mg kg-1, an infusion of erythromycin 400 mg was started. When 200 mg of erythromycin had been infused, the patient lost consciousness, but other vital functions remained normal. After 45 min, he awakened spontaneously. At the time the plasma concentration of midazolam was 134 ng ml-1...
December 1990: British Journal of Anaesthesia
B J Ebeling, W Müller, P Tonner, K T Olkkola, H Stoeckel
STUDY OBJECTIVE: To compare vecuronium requirements using repetitive injections and a model-based, closed-loop, feedback-controlled infusion during isoflurane anesthesia. DESIGN: Randomized open study. SETTING: Departments of Anesthesiology and Ear, Nose, and Throat Surgery at a university hospital. PATIENTS: Twenty-two patients of ASA physical status I or II undergoing elective otolaryngological surgery requiring general anesthesia...
May 1991: Journal of Clinical Anesthesia
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