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Doron D Sommer, Sadaf Arbab-Tafti, Forough Farrokhyar, Marc Tewfik, Allan Vescan, Ian J Witterick, Brian Rotenberg, Rakesh Chandra, Erik K Weitzel, Erin Wright, Jayant Ramakrishna
BACKGROUND: The goal of this study was to develop and evaluate the impact of an aviation-style challenge and response sinus surgery-specific checklist on potential safety and equipment issues during sinus surgery at a tertiary academic health center. The secondary goal was to assess the potential impact of use of the checklist on surgical times during, before, and after surgery. This initiative is designed to be utilized in conjunction with the "standard" World Health Organization (WHO) surgical checklist...
February 27, 2018: International Forum of Allergy & Rhinology
Karen De Ceunynck, Christian G Peters, Abhishek Jain, Sarah J Higgins, Omozuanvbo Aisiku, Jennifer L Fitch-Tewfik, Sharjeel A Chaudhry, Chris Dockendorff, Samir M Parikh, Donald E Ingber, Robert Flaumenhaft
Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing. Clinical use of APC, however, is limited by its immunogenicity and its anticoagulant activity. We show that a class of small molecules termed "parmodulins" that act at the cytosolic face of PAR1 stimulates APC-like cytoprotective signaling in endothelium. Parmodulins block thrombin generation in response to inflammatory mediators and inhibit platelet accumulation on endothelium cultured under flow...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
Radia Yahia, Chahinez Zaoui, Wafaa Derbale, Hafsa Boudi, Yahia Chebloune, Tewfik Sahraoui, Fatima Zohra Elkebir
Breast cancer is the common malignancy that affects women worldwide, but conventional risk factors account for only a small proportion of these cases. A possible viral etiology for breast cancer has been proposed and Epstein-Barr virus (EBV) is a widely studied candidate virus. The objective of this study is to determine the association of EBV infection with infiltrating ductal carcinomas (IDC). This descriptive study was carried out in the laboratory of developmental biology and differentiation, from 2012 to 2014...
January 16, 2018: Annales de Biologie Clinique
Roger Arditi, Claude Lobry, Tewfik Sari
The standard model for the dynamics of a fragmented density-dependent population is built from several local logistic models coupled by migrations. First introduced in the 1970s and used in innumerable articles, this standard model applied to a two-patch situation has never been fully analyzed. Here, we complete this analysis and we delineate the conditions under which fragmentation associated with dispersal is either favorable or unfavorable to total population abundance. We pay special attention to the case of asymmetric dispersal, i...
December 23, 2017: Theoretical Population Biology
Sarah Guerin, Aimee Stapleton, Drahomir Chovan, Rabah Mouras, Matthew Gleeson, Cian McKeown, Mohamed Radzi Noor, Christophe Silien, Fernando M F Rhen, Andrei L Kholkin, Ning Liu, Tewfik Soulimane, Syed A M Tofail, Damien Thompson
Piezoelectricity, the linear relationship between stress and induced electrical charge, has attracted recent interest due to its manifestation in biological molecules such as synthetic polypeptides or amino acid crystals, including gamma (γ) glycine. It has also been demonstrated in bone, collagen, elastin and the synthetic bone mineral hydroxyapatite. Piezoelectric coefficients exhibited by these biological materials are generally low, typically in the range of 0.1-10 pm V-1 , limiting technological applications...
February 2018: Nature Materials
Philip G Chen, K Christopher McMains, Marc A Tewfik, James K Aden, Seth Brown, Erik K Weitzel
OBJECTIVE: Frontal sinus anatomy is complex and often is a difficult subject to both teach and learn. The traditional surgical dogma of "see one, do one, teach one" is impractical and dangerous in the frontal sinus. Based on the building block three-dimensional conceptualization module, the Frontal Sinus Masterclass (FSMC) was created to teach this anatomy. METHODS: Study was performed at two academic centers among second- to fifth-year otolaryngology residents...
November 24, 2017: Laryngoscope
C Copelli, K Tewfik, L Cassano, N Pederneschi, S Catanzaro, A Manfuso, R Cocchi
Free flap surgery is overall considered the gold standard in head and neck reconstruction, with a success rate of 95%. The management of a total flap necrosis and which solution, between a pedicled or a second free flap, is safer for a salvage procedure is still controversial. Object of this study is to describe the authors' management of total free flap loss in head and neck reconstruction and compare the choices and results to those reported in the literature. From January 2012 to January 2016, 149 consecutive free flaps were performed at the Maxillo- Facial Operative Unit of the Hospital Casa Sollievo della Sofferenza in San Giovanni Rotondo (Italy) for reconstruction of head and neck defects...
October 2017: Acta Otorhinolaryngologica Italica
Sherif Mohamed Abdel Fattah
No abstract text is available yet for this article.
September 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
David L Chandler
In March 2017, Dr. Marc Tewfik performed a delicate operation to remove cancerous tissue from a patient's sinus cavity, something that he has done many times before at the McGill University Health Center (MUHC) in Montr?al, Canada. But this time, things were a bit different. Before performing such a minimally invasive surgery using a thin laparoscopic device inserted through the nose, the exact surgical plan was worked out in meticulous detail. Tewfik (Figure 1) used magnetic resonance imaging (MRI) scans to plot a pathway for the surgical tools to reach the target tissue without endangering arteries or nerves in an area just fractions of an inch from the optic nerve and from the brain itself...
September 2017: IEEE Pulse
Nicholas S Andresen, John M Buatti, Hamed H Tewfik, Nitin A Pagedar, Carryn M Anderson, John M Watkins
Management recommendations for differentiated thyroid cancer are evolving. Total thyroidectomy is the backbone of curative-intent therapy, with radioiodine ablation (RAI) of the thyroid remnant routinely performed, in order to facilitate serologic surveillance and reduce recurrence risk. Several single-institution series have identified patient subsets for whom recurrence risk is sufficiently low that RAI may not be indicated. Further, the appropriate dose of RAI specific to variable clinicopathologic presentations remains poorly defined...
July 2017: European Thyroid Journal
Sergey A Siletsky, Ilya Belevich, Nikolai P Belevich, Tewfik Soulimane, Mårten Wikström
Two electrogenic phases with characteristic times of ~14μs and ~290μs are resolved in the kinetics of membrane potential generation coupled to single-electron reduction of the oxidized "relaxed" O state of ba3 oxidase from T. thermophilus (O→E transition). The rapid phase reflects electron redistribution between CuA and heme b. The slow phase includes electron redistribution from both CuA and heme b to heme a3 , and electrogenic proton transfer coupled to reduction of heme a3 . The distance of proton translocation corresponds to uptake of a proton from the inner water phase into the binuclear center where heme a3 is reduced, but there is no proton pumping and no reduction of CuB ...
November 2017: Biochimica et Biophysica Acta
Murad Ali, Megersa Debela, Tewfik Bamud
This study examines the relative technical efficiency of 12 hospitals in Eastern Ethiopia. Using six-year-round panel data for the period between 2007/08 and 2012/13, this study examines the technical efficiency, total factor productivity, and determinants of the technical inefficiency of hospitals. Data envelopment analysis (DEA) and DEA- based Malmquist productivity index used to estimate relative technical efficiency, scale efficiency, and total factor productivity index of hospitals. Tobit model used to examine the determinants of the technical inefficiency of hospitals...
December 2017: Health Economics Review
Abdulaziz S Alrasheed, Lily H P Nguyen, Luc Mongeau, W Robert J Funnell, Marc A Tewfik
BACKGROUND: Endoscopic sinus surgery poses unique training challenges due to complex and variable anatomy, and the risk of major complications. We sought to create and provide validity evidence for a novel 3D-printed simulator of the nose and paranasal sinuses. METHODS: Sinonasal computed tomography (CT) images of a patient were imported into 3D visualization software. Segmentation of bony and soft tissue structures was then performed. The model was printed using simulated bone and soft tissue materials...
August 2017: International Forum of Allergy & Rhinology
Alessandro Bardazzi, Giada Anna Beltramini, Luca Autelitano, Roberto Bazzacchi, Dimitri Rabbiosi, Marco Pedrazzoli, Karim Tewfik, Angela Rezzonico, Federico Biglioli
The myomucosal buccinator flap, first described by Bozola in 1989, has become an important tool for intraoral defects reconstruction. In the literature, there is a variety of proposed myomucosal cheek flaps, both pedicled and island, based on the buccal or the facial arteries. From January 2007 to December 2011, the authors used a pedicled buccinator flap based posteriorly on the buccal artery to reconstruct partial lingual defects following tumor resection in 27 patients. The buccal fat pad was translated to cover the donor site defect...
June 2017: Journal of Craniofacial Surgery
Naif Fnais, Salvatore Di Maio, Susan Edionwe, Anthony Zeitouni, Denis Sirhan, Constanza J Valdes, Marc A Tewfik
Objectives The hemi-transseptal (Hemi-T) approach was developed to overcome the potential drawbacks of the nasoseptal flap (NSF) in endoscopic endonasal transsphenoidal skull base surgery. In this study, we describe further refinements on the Hemi-T approach, and report long-term outcomes as compared with traditional methods of skull base reconstruction. Design A retrospective case-control study. Setting Montreal Neurological Institute and Jewish General Hospital, Montreal, Canada. Participants Patients who underwent endoscopic endonasal transsphenoidal approach to skull base pathology...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
Adrian Nalichowski, Isaac Kaufman, John Gallo, Todd Bossenberger, Tim Solberg, Ezequiel Ramirez, Yulong Yan, Julie Fredrick, Tewfik Bichay, Alan Mayville, Jay Burmeister
There are numerous commercial radiotherapy systems capable of delivering single fraction spine radiosurgery/SBRT. We aim to compare the capabilities of several of these systems to deliver this treatment when following standardized criteria from a national protocol. Four distinct target lesions representing various case presentations of spine metastases were contoured in both the thoracic and lumbar spine of an anthropomorphic SBRT phantom. Single fraction radiosurgery/SBRT plans were designed for each target with each of our treatment platforms...
January 2017: Journal of Applied Clinical Medical Physics
Zenib Tahari, Asmahane Medjdoub, Tewfik Sahraoui, Leila Belhabri, Fatima Zohra El Kebir
BACKGROUND: Breast cancer is the most common cancer in women worldwide. Biology contributes to the early diagnosis and monitoring of breast cancer with several categories of markers such as prognostic markers (ER, PR, HER2), proliferative markers (Ki67), and tumor markers such as CEA and CA 15-3. CEA can be detected at a high concentration in serum of patients with malignant tumors. AIM: The aim of our study was to evaluate the concentrations of CEA in serum of women with breast cancer and to verify the existence of a possible link between the average rates of CEA and SBR grade...
January 2017: Gulf Journal of Oncology
Radhouane Fekih-Salem, Claude Lobry, Tewfik Sari
This paper deals with a two-microbial species model in competition for a single-resource in the chemostat including general intra- and interspecific density-dependent growth rates with distinct removal rates for each species. In order to understand the effects of intra- and interspecific interference, this general model is first studied by determining the conditions of existence and local stability of steady states. With the same removal rate, the model can be reduced to a planar system and then the global stability results for each steady state are derived...
April 2017: Mathematical Biosciences
Asmahane Medjdoub, Zineb Tahari, Leila Belhabri, Tewfik Sahraoui, Fatima Zohra El Kebir
AIM: The objective of this study was to evaluate the expression of hypoxia-inducible transcription factor 1α (HIF1α) protein profile among women with breast cancer in a population of western Algerian and to correlate the intensity of this expression with prognosis histological grade Scarff Bloom and Richardson (SBR) of the disease and the age of the patients. METHODS: We used a kit provided by Life Science Inc (UScnk) for a sandwich enzyme immunoassay for the quantitative measurement of in vitro HIF1α in plasma in 44 patients and 44 controls in a population of western Algerian...
September 2016: Gulf Journal of Oncology
Vijay Aditya Tadipatri, Ahmed Tewfik, Guiseppe Pellizzer, James Ashe
Long-term variability remains one of the major hurdles in using intra-cortical recordings like local field potentials for brain computer interfaces (BCI). Practical neural decoders need to overcome time instability of neural signals to estimate subject behavior accurately and faithfully over the long-term. This paper presents a novel decoder that a) characterizes each behavioral task (i.e. different movement directions under different force conditions) with multiple neural patterns and; b) adapts to the long-term variations in neural features by identifying the stable neural patterns...
April 20, 2016: IEEE Transactions on Bio-medical Engineering
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