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https://www.readbyqxmd.com/read/29081397/long-term-intermittent-high-amplitude-subcutaneous-nerve-stimulation-reduces-sympathetic-tone-in-ambulatory-dogs
#1
Yuan Yuan, Zhaolei Jiang, Ye Zhao, Wei-Chung Tsai, Jheel Patel, Lan S Chen, Changyu Shen, Shien-Fong Lin, Huei-Sheng Vincent Chen, Thomas H Everett, Michael C Fishbein, Zhenhui Chen, Peng-Sheng Chen
BACKGROUND: Reducing sympathetic efferent outflow from the stellate ganglia (SG) may be antiarrhythmic. OBJECTIVE: To test the hypothesis that chronic thoracic subcutaneous nerve stimulation (ScNS) could reduce SG nerve activity (SGNA) and control paroxysmal atrial tachycardia (PAT). METHODS: We performed thoracic ScNS in 8 dogs while monitoring the SGNA, vagal nerve activity (VNA) and subcutaneous nerve activity (ScNA). An additional 3 dogs were used for sham stimulation as controls...
October 25, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28969696/efficacy-of-rabies-vaccines-in-dogs-and-cats-and-protection-in-a-mouse-model-against-european-bat-lyssavirus-type-2
#2
Tiina Nokireki, Miia Jakava-Viljanen, Anna-Maija Virtala, Liisa Sihvonen
BACKGROUND: Rabies is preventable by pre- and/or post-exposure prophylaxis consisting of series of rabies vaccinations and in some cases the use of immunoglobulins. The success of vaccination can be estimated either by measuring virus neutralising antibodies or by challenge experiment. Vaccines based on rabies virus offer cross-protection against other lyssaviruses closely related to rabies virus. The aim was to assess the success of rabies vaccination measured by the antibody response in dogs (n = 10,071) and cats (n = 722), as well as to investigate the factors influencing the response to vaccination when animals failed to reach a rabies antibody titre of ≥ 0...
October 2, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28936868/a-microwave-flow-detector-for-gradient-elution-liquid-chromatography
#3
Duye Ye, Weizheng Wang, David Moline, Md Saiful Islam, Feng Chen, Pingshan Wang
This study presents a microwave flow detector technique for liquid chromatography (LC) application. The detector is based on a tunable microwave interferometer (MIM) with a vector network analyzer (VNA) for signal measurement and a computer for system control. A microstrip-line-based 0.3 μL flow cell is built and incorporated into the MIM. With syringe pump injection, the detector is evaluated by measuring a few common chemicals in DI water at multiple frequencies from 0.98 to 7.09 GHz. Less than 30 ng minimum detectable quantity (MDQ) is demonstrated...
October 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28874876/an-ultra-compact-rejection-filter-based-on-spoof-surface-plasmon-polaritons
#4
Shumin Zhao, Hao Chi Zhang, Jiahao Zhao, Wen Xuan Tang
In this paper, we propose a scheme to construct a new type of ultra-compact rejection filter by loading split-ring resonators (SRRs) on the transmission line of spoof surface plasmon polaritons (SPPs). From the dispersion analysis of the spoof SPP transmission line with and without the SRR loading, we clearly reveal the mechanism of the rejection characteristic for this compact filter. Meanwhile, we fabricate two spoof SPPs waveguides loaded with different amounts of metamaterials particles, and experimentally test them using an Agilent Vector Network Analyzer (VNA) and a homemade near-field scanning system...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28861771/recombinant-rabies-virus-expressing-il-15-enhances-immunogenicity-through-promoting-the-activation-of-dendritic-cells-in-mice
#5
Tiange Chen, Yajing Zhang, Zhao Wang, Jie Yang, Mingming Li, Kunlun Wang, Min Cui, Zhen F Fu, Ling Zhao, Ming Zhou
Rabies remains a public health threat that kills approximately 59,000 people worldwide each year, most of which are from the developing countries of Africa and Asia where dog rabies are endemic. Therefore, developing an affordable and efficacious vaccine is crucial for rabies control in these countries. Interleukin (IL)-15, an immunoregulatory cytokine, is a pluripotent molecule with therapeutic potential, which targets many cell types and links the innate and adaptive immune system. In this study, IL-15 gene was cloned and inserted into the genome of a recombinant rabies virus (RABV) strain LBNSE (designated as LBNSE-IL15), and the effect of over-expression of IL-15 on the immunogenicity of RABV was investigated...
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28857541/enhanced-x-band-electromagnetic-interference-shielding-performance-of-layer-structured-fabric-supported-polyaniline-cobalt-nickel-coatings
#6
Hang Zhao, Lei Hou, Siyi Bi, Yinxiang Lu
Despite tremendous efforts, fabrication of lightweight conductive fabrics for high-performance X-band electromagnetic-interference (EMI) shielding remains a daunting technical challenge. We herein report an ingenious and efficient strategy to deposit polyaniline/cobalt-nickel (PANI/Co-Ni) coatings onto lyocell fabrics that involves consecutive steps of in situ polymerization and electroless plating. The PANI-Co-Ni ternary-component system successfully induced a synergistic effect from EM wave-absorption and EM wave-reflection and, moreover, upgraded the match level between magnetic loss and dielectric loss...
September 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28822816/genetically-modified-rabies-virus-vectored-ebola-virus-disease-vaccines-are-safe-and-induce-efficacious-immune-responses-in-mice-and-dogs
#7
Lei Shuai, Xijun Wang, Zhiyuan Wen, Jinying Ge, Jinliang Wang, Dandan Zhao, Zhigao Bu
Ebola viruses (EBOVs) are zoonotic pathogens that cause EBOV disease (EVD) with high case fatality in humans. Currently, EVD vaccines are still under development in several countries. Here, we generated two recombinant rabies viruses (RABVs), rERAG333E/ZGP and rERAG333E/SGP, expressing the Zaire EBOV glycoprotein (ZGP) or Sudan EBOV glycoprotein (SGP) gene based on a modified ERA vaccine strain (rERAG333E) vector platform. The recombinant RABVs retained growth properties similar to those of the vector virus in BSR cell culture and efficiently expressed ZGP or SGP...
August 16, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28766059/protective-immune-response-of-oral-rabies-vaccine-in-stray-dogs-corsacs-and-steppe-wolves-after-a-single-immunization
#8
K Zhugunissov, Ye Bulatov, D Taranov, Z Yershebulov, Zh Koshemetov, Ye Abduraimov, Zh Kondibayeva, A Samoltyrova, Zh Amanova, B Khairullin, A Sansyzbay
In this study the safety and protective immunity of an oral rabies vaccine, based on the live, modified rabies virus strain VRC-RZ2, was examined in stray dogs (Canis Sp.), corsacs (Vulpes corsac) and steppe wolves (Canis lupus campestris). In the safety group (dogs, n=6; corsacs, n=3; wolves, n=3) which was vaccinated with a 10-times field dose/animal, no animals showed any signs of disease or changes in behavior or appetite during the period of clinical observation, similar to the animals in the negative control group...
November 2017: Archives of Virology
https://www.readbyqxmd.com/read/28727561/a-cots-based-microwave-imaging-system-for-breast-cancer-detection
#9
Mario R Casu, Marco Vacca, Jorge A Tobon, Azzurra Pulimeno, Imran Sarwar, Raffaele Solimene, Francesca Vipiana
Microwave imaging is an emerging breast cancer diagnostic technique, which aims at complementing already established methods like mammography, magnetic resonance imaging, and ultrasound. It offers two striking advantages: no-risk for the patient and potential low-cost for national health systems. So far, however, the prototypes developed for validation in labs and clinics used costly lab instruments such as a vector network analyzer (VNA). Moreover, the CPU time required by complex image reconstruction algorithms may not be compatible with the duration of a medical examination...
August 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28660781/variability-in-biological-behaviour-pathogenicity-protectotype-and-induction-of-virus-neutralizing-antibodies-by-different-vaccination-programmes-to-infectious-bronchitis-virus-genotype-q1-strains-from-chile
#10
J J de Wit, R Dijkman, P Guerrero, J Calvo, A Gonzalez, H Hidalgo
In the period from July 2008 to 2010, a disease episode resulting in serious economic losses in the major production area of the Chilean poultry industry was reported. These losses were associated with respiratory problems, increase of condemnations, drops in egg production and nephritis in breeders, laying hens and broilers due to infections with infectious bronchitis virus (IBV). Twenty-five IBV isolates were genotyped and four strains were selected for further testing by pathotyping and protectotyping. Twenty-four IBV isolates were of the Q1 genotype...
August 22, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28506631/susceptibility-of-neuroblastoma-cells-to-rabies-virus-may-be-affected-by-passage-number
#11
Craig Pouliott, Michelle Dupuis, Kim Appler, Scott Brunt, Robert Rudd, April Davis
Maintaining a healthy, continuous immortalized cell line is essential for rabies laboratories that perform virus isolation assays and test for the presence of viral neutralizing antibodies. Individuals who routinely work with rabies virus, such as rabies laboratory employees, or those who may have a high potential for exposure to rabies virus, including veterinarians, should be tested for the presence of anti-rabies viral neutralizing antibodies (VNA) every 6-24 months, depending on potential exposure level...
September 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28490138/contamination-of-chinese-salted-fish-with-volatile-n-nitrosamines-as-determined-by-quechers-and-gas-chromatography-tandem-mass-spectrometry
#12
Yuesheng Qiu, Jie-Hua Chen, Weijun Yu, Pei Wang, Minxian Rong, Hong Deng
The QuEChERS sample preparation method and gas chromatography-tandem mass spectrometry were employed to determine nine volatile N-nitrosamines (VNAs) in Chinese salted fish. This method was validated by considering calibration plot linearity, selectivity, matrix effects, trueness, precision, limits of quantification and specificity. Fifty-four samples of Chinese salted fish obtained from five provinces were analyzed. The results indicated that the concentrations of one VNA, N-nitrosodimethylamine in 57.4% of the samples exceeded the acceptable limit (the China national standard value of 4μgkg(-1)), and total VNA contents in 68...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28490112/real-time-monitoring-of-sucrose-sorbitol-d-glucose-and-d-fructose-concentration-by-electromagnetic-sensing
#13
Supakorn Harnsoongnoen, Anuwat Wanthong
Magnetic sensing at microwave frequencies for real-time monitoring of sucrose, sorbitol, d-glucose and d-fructose concentrations is reported. The sensing element was designed based on a coplanar waveguide (CPW) loaded with a split ring resonator (SRR), which was fabricated on a DiClad 880 substrate with a thickness of 1.6mm and relative permittivity (εr) of 2.2. The magnetic sensor was connected to a Vector Network Analyzer (VNA) and the electromagnetic interaction between the samples and sensor was analyzed...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28417925/a-cost-effective-geodetic-strainmeter-based-on-dual-coaxial-cable-bragg-gratings
#14
Jihua Fu, Xu Wang, Tao Wei, Meng Wei, Yang Shen
Observations of surface deformation are essential for understanding a wide range of geophysical problems, including earthquakes, volcanoes, landslides, and glaciers. Current geodetic technologies, such as global positioning system (GPS), interferometric synthetic aperture radar (InSAR), borehole and laser strainmeters, are costly and limited in their temporal or spatial resolutions. Here we present a new type of strainmeters based on the coaxial cable Bragg grating (CCBG) sensing technology that provides cost-effective strain measurements...
April 12, 2017: Sensors
https://www.readbyqxmd.com/read/28317660/safety-tolerability-and-efficacy-of-intradermal-rabies-immunization-with-debioject%C3%A2
#15
Paul Vescovo, Nils Rettby, Nirinarilala Ramaniraka, Julie Liberman, Karen Hart, Astrid Cachemaille, Laurent-Dominique Piveteau, Reto Zanoni, Pierre-Alexandre Bart, Giuseppe Pantaleo
In a single-center study, 66 healthy volunteers aged between 18 and 50years were randomized to be immunized against rabies with three different injection routes: intradermal with DebioJect™ (IDJ), standard intradermal with classical needle (IDS), also called Mantoux method, and intramuscular with classical needle (IM). "Vaccin rabique Pasteur®" and saline solution (NaCl 0.9%) were administered at D0, D7 and D28. Antigen doses for both intradermal routes were 1/5 of the dose for IM. Tolerability, safety and induced immunogenicity of IDJ were compared to IDS and IM routes...
March 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28151079/exposure-to-lyssaviruses-in-bats-of-the-democratic-republic-of-the-congo
#16
Lem's N Kalemba, Michael Niezgoda, Amy T Gilbert, Jeffrey B Doty, Ryan M Wallace, Jean M Malekani, Darin S Carroll
Lyssavirus infections in the Democratic Republic of Congo are poorly documented. We examined 218 bats. No lyssavirus antigens were detected but Lagos bat virus (LBV) neutralizing antibodies (VNA) were detected in Eidolon helvum and Myonycteris torquata . Four samples with LBV VNA reacted against Shimoni bat virus.
April 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28113238/channel-modeling-of-miniaturized-battery-powered-capacitive-human-body-communication-systems
#17
Jiwoong Park, Harinath Garudadri, Patrick P Mercier
The purpose of this contribution is to estimate the path loss of capacitive human body communication (HBC) systems under practical conditions. METHODS: Most prior work utilizes large, grounded instruments to perform path loss measurements, resulting in overly optimistic path loss estimates for wearable HBC devices. In this paper, small battery-powered transmitter and receiver devices are implemented to measure path loss under realistic assumptions. A hybrid electrostatic-FEM simulation model is presented that validates measurements and enables rapid and accurate characterization of future capacitive HBC systems...
April 29, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28100620/overexpression-of-interleukin-7-extends-the-humoral-immune-response-induced-by-rabies-vaccination
#18
Yingying Li, Ming Zhou, Zhaochen Luo, Yachun Zhang, Min Cui, Huanchun Chen, Zhen F Fu, Ling Zhao
Rabies continues to present a public health threat in most countries of the world. The most efficient way to prevent and control rabies is to implement vaccination programs for domestic animals. However, traditional inactivated vaccines used in animals are costly and have relatively low efficiency, which impedes their extensive use in developing countries. There is, therefore, an urgent need to develop single-dose and long-lasting rabies vaccines. However, little information is available regarding the mechanisms underlying immunological memory, which can broaden humoral responses following rabies vaccination...
April 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28089546/expression-of-interleukin-6-by-a-recombinant-rabies-virus-enhances-its-immunogenicity-as-a-potential-vaccine
#19
Jun Luo, Boyue Zhang, Yuting Wu, Qin Tian, Jing Zhao, Ziyu Lyu, Qiong Zhang, Mingzhu Mei, Yongwen Luo, Xiaofeng Guo
Several studies have confirmed that interleukin-6 (IL6) mediates multiple biological effects that enhance immune responses when used as an adjuvant. In the present study, recombinant rabies virus (RABV) expressing canine IL6 (rHEP-CaIL6) was rescued and its pathogenicity and immunogenicity were investigated in mice. We demonstrated that mice received a single intramuscular immunization with rHEP-CaIL6 showed an earlier increase and higher maximum titres of virus-neutralizing antibody (VNA) as well as anti-RABV antibodies compared with mice immunized with the parent strain...
January 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28075375/an-approach-to-biometric-verification-based-on-human-body-communication-in-wearable-devices
#20
Jingzhen Li, Yuhang Liu, Zedong Nie, Wenjian Qin, Zengyao Pang, Lei Wang
In this paper, an approach to biometric verification based on human body communication (HBC) is presented for wearable devices. For this purpose, the transmission gain S21 of volunteer's forearm is measured by vector network analyzer (VNA). Specifically, in order to determine the chosen frequency for biometric verification, 1800 groups of data are acquired from 10 volunteers in the frequency range 0.3 MHz to 1500 MHz, and each group includes 1601 sample data. In addition, to achieve the rapid verification, 30 groups of data for each volunteer are acquired at the chosen frequency, and each group contains only 21 sample data...
January 10, 2017: Sensors
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