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https://www.readbyqxmd.com/read/29356366/choroidal-thickness-at-age-66%C3%A2-years-in-the-danish-high-myopia-study-cohort-1948-compared-with-follow-up-data-on-visual-acuity-over-40%C3%A2-years-a-clinical-update-adding-spectral-domain-optical-coherence-tomography
#1
Hans C Fledelius, Nina Jacobsen, Xiao Q Li, Ernst Goldschmidt
BACKGROUND AND PURPOSE: A population-based Copenhagen birth year 1948 cohort with high myopia recorded since age 14 years (spherical equivalent less than or equivalent to -6 D) has been followed over 50 years. Despite complications, current follow-ups have outlined a better visual prognosis than usually drawn from selected clinical series in the literature. For the present status at age 66 years, focus was on visual ability and choroidal thickness. METHODS: Twenty-eight of the original 39 participants were available in 2014...
February 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29356350/1918-pandemic-morbidity-the-first-wave-hits-the-poor-the-second-wave-hits-the-rich
#2
Svenn-Erik Mamelund
BACKGROUND: Whether morbidity from the 1918-19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was "socially neutral". OBJECTIVES: To study the associations between Influenza like illness (ILI) and socioeconomic status (SES), gender and wave during the 1918-19 influenza pandemic. METHODS: Availability of incidence data on the 1918-19 pandemic is scarce, in particular for waves other than the "fall wave" October-December 1918...
January 21, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29356315/utility-values-for-childhood-obesity-interventions-a-systematic-review-and-meta-analysis-of-the-evidence-for-use-in-economic-evaluation
#3
REVIEW
V Brown, E J Tan, A J Hayes, S Petrou, M L Moodie
Rigorous estimates of preference-based utilities are important inputs into economic evaluations of childhood obesity interventions, yet no published review currently exists examining utility by weight status in paediatric populations. A comprehensive systematic literature review and meta-analysis was therefore undertaken, pooling data on preference-based health state utilities by weight status in children using a random-effects model. Tests for heterogeneity were performed, and publication bias was assessed...
January 21, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29356291/blood-flow-restriction-and-cuff-width-effect-on-blood-flow-in-the-legs
#4
J Grant Mouser, Scott J Dankel, Kevin T Mattocks, Matthew B Jessee, Samuel L Buckner, Takashi Abe, Jeremy P Loenneke
Much of the literature examining blood flow restriction in the lower body uses cuffs of differing widths. It is currently unknown whether similar relative pressures using cuffs of differing widths elicit the same blood flow response. PURPOSE: To examine the hemodynamic responses to relative pressures using two commonly used cuffs (10 and 12 cm). METHODS: In a random order over two laboratory visits, one cuff was applied to the right proximal thigh of the participant (men = 17, women = 14), and arterial occlusion pressure (AOP) was measured...
January 21, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29356239/phonological-processing-during-silent-reading-in-teenagers-who-are-deaf-hard-of-hearing-an-eye-movement-investigation
#5
Hazel I Blythe, Jonathan H Dickins, Colin R Kennedy, Simon P Liversedge
There has been considerable variability within the literature concerning the extent to which deaf/hard of hearing individuals are able to process phonological codes during reading. Two experiments are reported in which participants' eye movements were recorded as they read sentences containing correctly spelled words (e.g., church), pseudohomophones (e.g., cherch), and spelling controls (e.g., charch). We examined both foveal processing and parafoveal pre-processing of phonology for three participant groups-teenagers with permanent childhood hearing loss (PCHL), chronological age-matched controls, and reading age-matched controls...
January 22, 2018: Developmental Science
https://www.readbyqxmd.com/read/29356226/-i-know-i-m-not-invincible-an-interpretative-phenomenological-analysis-of-thyroid-cancer-in-young-people
#6
Stephanie Smith, Virginia Eatough, James Smith, Radu Mihai, Andrew Weaver, Gregory P Sadler
OBJECTIVE: Thyroid cancer is one of the most common cancers affecting young people and carries an excellent prognosis. Little is known about the psychosocial issues that face young people diagnosed with a treatable cancer. This study explored how young people experienced diagnosis, treatment, and how they made sense of an experience which challenged their views on what it means to have cancer. METHOD: Semi-structured interviews were conducted with eight young people diagnosed with either papillary or follicular thyroid cancer, and analysed with interpretative phenomenological analysis (IPA)...
January 22, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29356205/antiviral-potential-of-medicinal-plants-against-hiv-hsv-influenza-hepatitis-and-coxsackievirus-a-systematic-review
#7
REVIEW
Muhammad Akram, Imtiaz Mahmood Tahir, Syed Muhammad Ali Shah, Zahed Mahmood, Awais Altaf, Khalil Ahmad, Naveed Munir, Muhammad Daniyal, Suhaila Nasir, Huma Mehboob
Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections...
January 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29356192/how-much-of-toyota-s-philosophy-is-embedded-in-health-care-at-the-organisational-level-a-review
#8
Alain Antierens, Dimitri Beeckman, Sofie Verhaeghe, Dries Myny, Ann Van Hecke
AIMS: Identify which of Toyota's principles are reported in health care institutions at the organisational level and to identify the type of reported outcomes related to the effectiveness of lean production reported in these studies. BACKGROUND: No scientific research has been conducted to determine which of Toyota's principles are embedded in health care systems. This knowledge is needed to perform targeted adjustments in health care. EVALUATION: Sixty studies were identified for the final analysis...
January 22, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29356185/medicinal-uses-pharmacology-and-phytochemistry-of-convolvulaceae-plants-with-central-nervous-system-efficacies-a-systematic-review
#9
REVIEW
Guang-Tong Chen, Yun Lu, Min Yang, Jian-Lin Li, Bo-Yi Fan
Central nervous system (CNS) disorders play a major impact on individual lives and place a severe strain on health care resources. Convolvulaceae is a family comprising approximately 1,600-1,700 species grouped in 55-60 genera, and many species are reported to have an effect on CNS functions. A systematic review of the literature studies was carried out to summarize available evidences on Convolvulaceae plants with CNS efficacies. This review is based on various data sources such as Google Scholar, Web of Science, Scopus, PubMed, and Wanfang Data...
January 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29356165/period-prevalence-and-reporting-rate-of-medication-errors-among-nurses-in-iran-a-systematic-review-and-meta-analysis
#10
Behzad Karami Matin, Mohammad Hajizadeh, Bijan Nouri, Shahab Rezaeian, Masoud Mohammadi, Satar Rezaei
AIMS: To estimate the 1-year period prevalence of medication errors and the reporting rate to nurse managers among nurses working in hospitals in Iran. BACKGROUND: Medication errors are one of the main factors affecting the quality of hospital services and reducing patient safety in health care systems. METHOD: A literature search from Iranian and international scientific databases was developed to find relevant studies. Meta-regression was used to identify which characteristics may have a confounding effect on the pooled prevalence estimates...
January 22, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29356106/pigmented-fungiform-lingual-papillae-dermoscopic-and-clinical-features
#11
REVIEW
Marco Adriano Chessa, Annalisa Patrizi, Andrea Sechi, Annalucia Virdi, Miriam Leuzzi, Iria Neri
BACKGROUND: The tongue is covered by fungiform, filiform and circumvallate papillae. Fungiform papillae may be mainly pigmented in dark-skinned individuals. OBJECTIVE: A single-center study aimed to examine the clinical and dermoscopic features of pigmented fungiform papulae of the tongue (PFPT) in children, and a concise review of the literature has been performed. METHODS: The clinical and anamnestic data of 8 children affected by PFPT visited at the Pediatric Dermatology Unit of Bologna between 2010 and 2017, and a sistemic review of all studies of PFPT published on Pubmed up to August 31, 2017 have been collected and analyzed...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29356088/exposure-of-the-developing-heart-to-diabetic-environment-and-early-cardiac-assessment-a-review
#12
REVIEW
Mehmet R Asoglu, Rinat Gabbay-Benziv, Ozhan M Turan, Sifa Turan
Hyperglycemia during organogenesis is associated with an increased risk of congenital cardiac defects (CHDs). The pathophysiology leading to CHDs is not completely uncovered. However, elevated oxidative stress is considered to be the primary trigger that causes CHDs in fetuses of diabetic mothers. Maternal diabetes has been found to increase the risk for all types of CHDs. Diabetes may also impact the fetal cardiac performance at all gestational ages. Early detection of CHDs has certain advantages, such as making early decision about termination of pregnancy, enabling early genetic testing, and early reassurance if scan is normal...
January 21, 2018: Echocardiography
https://www.readbyqxmd.com/read/29356026/light-emitting-diodes-in-dermatology-a-systematic-review-of-randomized-controlled-trials
#13
Jared Jagdeo, Evan Austin, Andrew Mamalis, Christopher Wong, Derek Ho, Daniel Siegel
OBJECTIVE: In dermatology, patient and physician adoption of light-emitting diode (LED) medical technology continues to grow as research indicates that LEDs may be used to treat skin conditions. The goal of this systematic review is to critically analyze published randomized controlled trials (RCTs) and provide evidence-based recommendations on the therapeutic uses of LEDs in dermatology based on published efficacy and safety data. METHODS: A systematic review of the published literature on the use of LED treatments for skin conditions was performed on September 13th 2017...
January 22, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29356001/early-versus-delayed-invasive-strategy-for-intermediate-and-high-risk-acute-coronary-syndromes-managed-without-p2y12-receptor-inhibitor-pretreatment-design-and-rationale-of-the-early-randomized-trial
#14
Gilles Lemesle, Marc Laine, Mathieu Pankert, Etienne Puymirat, Thomas Cuisset, Ziad Boueri, Luc Maillard, Sébastien Armero, Guillaume Cayla, Laurent Bali, Pascal Motreff, Jean-Pascal Peyre, Franck Paganelli, François Kerbaul, Antoine Roch, Pierre Michelet, Karine Baumstarck, Laurent Bonello
According to recent literature, pretreatment with a P2Y12 ADP receptor antagonist before coronary angiography appears no longer suitable in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) due to an unfavorable risk-benefit ratio. Optimal delay of the invasive strategy in this specific context is unknown. We hypothesize that without P2Y12 ADP receptor antagonist pretreatment, a very early invasive strategy may be beneficial. The EARLY trial (Early or Delayed Revascularization for Intermediate- and High-Risk Non-ST-Segment Elevation Acute Coronary Syndromes?) is a prospective, multicenter, randomized, controlled, open-label, 2-parallel-group study that plans to enroll 740 patients...
January 22, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29356000/generalized-reactions-during-skin-testing-with-clindamycin-in-drug-hypersensitivity-a-report-of-3-cases-and-review-of-the-literature
#15
Eleni Papakonstantinou, Sabine Müller, Jan H Röhrbein, Dorothea Wieczorek, Alexander Kapp, Thilo Jakob, Bettina Wedi
BACKGROUND: The diagnostic approach to drug hypersensitivity includes a detailed medical history, clinical examination, and skin testing and/or oral challenge with a culprit or alternative drug, depending on the type of reaction and the suspected drugs. Although skin testing is considered to be rather safe, cutaneous and systemic, including fatal, reactions have been described. OBJECTIVES: To report 3 cases with generalized delayed reactions after skin testing with clindamycin, and to review the existing literature...
January 22, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29355955/complex-neuroprotective-and-neurotoxic-effects-of-histone-deacetylases
#16
REVIEW
Elizabeth A Thomas, Santosh R D'Mello
By their ability to shatter quality of life for both patients and caregivers, neurodegenerative diseases are the most devastating of human disorders. Unfortunately, there are no effective or long-terms treatments capable of slowing down the relentless loss of neurons in any of these diseases. One impediment is the lack of detailed knowledge of the molecular mechanisms underlying the processes of neurodegeneration. While some neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Amyotrophic lateral sclerosis, are mostly sporadic in nature, driven by both environment and genetic susceptibility, many others, including Huntington's disease, Spinocerebellar ataxias and Spinal-bulbar muscular atrophy, are genetically inherited disorders...
January 22, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29355940/doxorubicin-mesenchymal-stem-cell-toxicity-and-antitumour-activity-implications-for-clinical-use
#17
REVIEW
Mia Baxter-Holland, Crispin R Dass
OBJECTIVES: The use of doxorubicin, an antineoplastic medication used for the treatment of cancers via mechanisms that prevent replication of cells or lead to their death, can result in damage to healthy cells as well as malignant. Among the affected cells are mesenchymal stem cells (MSCs), which are involved in the maintenance and repair of tissues in the body. This review explores the mechanisms of biological effects and damage attributed to doxorubicin on MSCs. The PubMed database was used as a source of literature for this review...
January 22, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29355892/the-effect-of-ethnicity-on-the-performance-of-protein-creatinine-ratio-in-the-prediction-of-significant-proteinuria-in-pregnancies-at-risk-of-or-with-established-hypertension-an-implementation-audit-and-cost-implications
#18
Sadia Bhatti, Mark Cordina, Leonie Penna, Roy Sherwood, Tracy Dew, Nikos A Kametas
INTRODUCTION: The replacement of 24-hour urine collection by protein-creatinine ratio (PCR) for the diagnosis of pre-eclampsia has been recently recommended. However, the literature is conflicting and there are concerns on the impact of demographic characteristics on the performance of PCR. MATERIALS AND METHODS: This was an implementation audit of the introduction of PCR in a London Tertiary obstetric unit. The performance of PCR in the prediction of proteinuria ≥300mg/day was assessed in 476 women with suspected pre-eclampsia who completed a 24-hour urine collection and an untimed urine sample for PCR calculation...
January 21, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29355886/antidepressants-for-depression-in-adults-with-hiv-infection
#19
REVIEW
Ingrid Eshun-Wilson, Nandi Siegfried, Dickens H Akena, Dan J Stein, Ekwaro A Obuku, John A Joska
BACKGROUND: Rates of major depression among people living with HIV (PLWH) are substantially higher than those seen in the general population and this may adversely affect antiretroviral treatment outcomes. Several unique clinical and psychosocial factors may contribute to the development and persistence of depression in PLWH. Given these influences, it is unclear if antidepressant therapy is as effective for PLWH as the general population. OBJECTIVES: To assess the efficacy of antidepressant therapy for treatment of depression in PLWH...
January 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29355823/the-influence-of-immunological-stressors-on-traumatic-brain-injury
#20
REVIEW
Mujun Sun, Stuart J McDonald, Rhys D Brady, Terence J O'Brien, Sandy R Shultz
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, and typically involves a robust immune response. Although a great deal of preclinical research has been conducted to identify an effective treatment, all phase III clinical trials have been unsuccessful to date. These translational shortcomings are in part due to a failure to recognize and account for the heterogeneity of TBI, including how extracranial factors can influence the aftermath of TBI. For example, most preclinical studies have utilized isolated TBI models in young adult males, while clinical trials typically involve highly heterogeneous patient populations (e...
January 17, 2018: Brain, Behavior, and Immunity
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