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https://www.readbyqxmd.com/read/29777921/comparison-of-heavy-metals-parasites-and-histopathology-in-sculpins-myoxocephalus-spp-from-two-sites-at-a-lead-zinc-mine-in-north-east-greenland
#1
Rasmus Dyrmose Nørregaard, Mai Dang, Lis Bach, Ole Geertz-Hansen, Kim Gustavson, Peter Aastrup, Pall S Leifsson, Jens Søndergaard, Barbara Nowak, Christian Sonne
The former lead-zinc mine at Mestersvig, Greenland, continues to contaminate the surrounding environment despite its operations ceasing over 50 years ago. Elevated concentrations of heavy metals are found in water, sediment and biota in the terrestrial, freshwater and marine environments. To shed light on the present contamination and its potential effects on local fish we investigated gill and liver histology of sculpins (Myoxocephalus spp.) around the former mining area. Two species of sculpins were caught; shorthorn sculpins (M...
May 16, 2018: Environmental Research
https://www.readbyqxmd.com/read/29776520/commercial-truck-crash-injury-severity-analysis-using-gradient-boosting-data-mining-model
#2
Zijian Zheng, Pan Lu, Brenda Lantz
INTRODUCTION: Truck crashes contribute to a large number of injuries and fatalities. This study seeks to identify the contributing factors affecting truck crash severity using 2010 to 2016 North Dakota and Colorado crash data provided by the Federal Motor Carrier Safety Administration. METHOD: To fulfill a gap of previous studies, broad considerations of company and driver characteristics, such as company size and driver's license class, along with vehicle types and crash characteristics are researched...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29775406/phrase-mining-of-textual-data-to-analyze-extracellular-matrix-protein-patterns-across-cardiovascular-disease
#3
David Alexandre Liem, Sanjana Murali, Dibakar Sigdel, Yu Shi, Xuan Wang, Jiaming Shen, Howard Choi, J Harry Caufield, Wei Wang, Peipei Ping, Jiawei Han
Extracellular matrix (ECM) proteins have been shown to play important roles regulating multiple biological processes in an array of organ systems, including the cardiovascular system. By using a novel bioinformatics text-mining tool, we studied six categories of cardiovascular disease (CVD), namely ischemic heart disease (IHD), cardiomyopathies (CM), cerebrovascular accident (CVA), congenital heart disease (CHD), arrhythmias (ARR), and valve disease (VD), anticipating novel ECM protein-disease and protein-protein relationships hidden within vast quantities of textual data...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29775382/data-mining-cmmss-how-to-convert-data-into-knowledge
#4
Larry Fennigkoh, D Courtney Nanney
Although the healthcare technology management (HTM) community has decades of accumulated medical device-related maintenance data, little knowledge has been gleaned from these data. Finding and extracting such knowledge requires the use of the well-established, but admittedly somewhat foreign to HTM, application of inferential statistics. This article sought to provide a basic background on inferential statistics and describe a case study of their application, limitations, and proper interpretation. The research question associated with this case study involved examining the effects of ventilator preventive maintenance (PM) labor hours, age, and manufacturer on needed unscheduled corrective maintenance (CM) labor hours...
January 2018: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/29774397/inclusion-of-dosimetric-data-as-covariates-in-toxicity-related-radiogenomic-studies-a-systematic-review
#5
Noorazrul Yahya, Xin-Jane Chua, Hanani A Manan, Fuad Ismail
PURPOSE: This systematic review evaluates the completeness of dosimetric features and their inclusion as covariates in genetic-toxicity association studies. MATERIALS AND METHODS: Original research studies associating genetic features and normal tissue complications following radiotherapy were identified from PubMed. The use of dosimetric data was determined by mining the statement of prescription dose, dose fractionation, target volume selection or arrangement and dose distribution...
May 17, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29774391/comparison-of-left-ventricular-hypertrophy-by-electrocardiography-and-echocardiography-in-children-using-analytics-tool
#6
Lauren Tague, Justin Wiggs, Qianxi Li, Robert McCarter, Elizabeth Sherwin, Jacqueline Weinberg, Craig Sable
Left ventricular hypertrophy (LVH) is a common finding on pediatric electrocardiography (ECG) leading to many referrals for echocardiography (echo). This study utilizes a novel analytics tool that combines ECG and echo databases to evaluate ECG as a screening tool for LVH. SQL Server 2012 data warehouse incorporated ECG and echo databases for all patients from a single institution from 2006 to 2016. Customized queries identified patients 0-18 years old with LVH on ECG and an echo performed within 24 h. Using data visualization (Tableau) and analytic (Stata 14) software, ECG and echo findings were compared...
May 17, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29773907/an-approach-to-monitoring-home-cage-behavior-in-mice-that-facilitates-data-sharing
#7
Edoardo Balzani, Matteo Falappa, Fuat Balcà, Valter Tucci
Genetically modified mice are used as models for a variety of human behavioral conditions. However, behavioral phenotyping can be a major bottleneck in mouse genetics because many of the classic protocols are too long and/or are vulnerable to unaccountable sources of variance, leading to inconsistent results between centers. We developed a home-cage approach using a Chora feeder that is controlled by-and sends data to-software. In this approach, mice are tested in the standard cages in which they are held for husbandry, which removes confounding variables such as the stress induced by out-of-cage testing...
June 2018: Nature Protocols
https://www.readbyqxmd.com/read/29772817/computational-convolution-of-seldi-data-for-the-diagnosis-of-alzheimer-s-disease
#8
Destiny E O Anyaiwe, Gautam B Singh, George D Wilson, Timothy J Geddes
Alzheimer's disease is rapidly becoming an endemic for people over the age of 65. A vital path towards reversing this ominous trend is the building of reliable diagnostic devices for definite and early diagnoses in lieu of the longitudinal, usually inconclusive and non-generalize-able methods currently in use. In this article, we present a survey of methods for mining pools of mass spectrometer saliva data in relation to diagnosing Alzheimer's disease. The computational methods provides new approaches for appropriately gleaning latent information from mass spectra data...
May 17, 2018: High-throughput
https://www.readbyqxmd.com/read/29771663/applications-of-deep-learning-and-reinforcement-learning-to-biological-data
#9
Mufti Mahmud, Mohammed Shamim Kaiser, Amir Hussain, Stefano Vassanelli
Rapid advances in hardware-based technologies during the past decades have opened up new possibilities for life scientists to gather multimodal data in various application domains, such as omics, bioimaging, medical imaging, and (brain/body)-machine interfaces. These have generated novel opportunities for development of dedicated data-intensive machine learning techniques. In particular, recent research in deep learning (DL), reinforcement learning (RL), and their combination (deep RL) promise to revolutionize the future of artificial intelligence...
June 2018: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29771380/dbcan2-a-meta-server-for-automated-carbohydrate-active-enzyme-annotation
#10
Han Zhang, Tanner Yohe, Le Huang, Sarah Entwistle, Peizhi Wu, Zhenglu Yang, Peter K Busk, Ying Xu, Yanbin Yin
Complex carbohydrates of plants are the main food sources of animals and microbes, and serve as promising renewable feedstock for biofuel and biomaterial production. Carbohydrate active enzymes (CAZymes) are the most important enzymes for complex carbohydrate metabolism. With an increasing number of plant and plant-associated microbial genomes and metagenomes being sequenced, there is an urgent need of automatic tools for genomic data mining of CAZymes. We developed the dbCAN web server in 2012 to provide a public service for automated CAZyme annotation for newly sequenced genomes...
May 16, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29770756/the-influence-of-juicing-on-the-appearance-of-blueberry-metabolites-2-h-after-consumption-a-metabolite-profiling-approach
#11
Swen Langer, Aileen Kennel, John K Lodge
The consumption of berries has been linked to decreased risk of degenerative disease. Berries are regularly processed into juices. It is largely unknown how the juicing process affects the bioavailability of metabolites. As metabolomics has shown to be a valuable nutritional tool to study global metabolite differences, the aim of this study was to investigate the effect of juicing on the relative appearance of blueberry metabolites in humans using metabolomics. Nine healthy subjects consumed 250 g of fresh blueberries either as the whole fruit or after juicing, and provided blood and urine samples before and 2 h after intake in a cross-over design...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29768624/analysis-of-the-immunological-biomarker-profile-during-acute-zika-virus-infection-reveals-the-overexpression-of-cxcl10-a-chemokine-linked-to-neuronal-damage
#12
Felipe Gomes Naveca, Gemilson Soares Pontes, Aileen Yu-Hen Chang, George Allan Villarouco da Silva, Valdinete Alves do Nascimento, Dana Cristina da Silva Monteiro, Marineide Souza da Silva, Lígia Fernandes Abdalla, João Hugo Abdalla Santos, Tatiana Amaral Pires de Almeida, Matilde Del Carmen Contreras Mejía, Tirza Gabrielle Ramos de Mesquita, Helia Valeria de Souza Encarnação, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Ana Carolina Campi-Azevedo, Jordana Graziela Coelho-Dos-Reis, Lis Ribeiro do Vale Antonelli, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rajendranath Ramasawmy
BACKGROUND: Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES: To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS: We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29766637/subtype-specific-clinical-and-prognostic-relevance-of-tumor-expressed-f5-and-regulatory-f5-variants-in-breast-cancer-the-cocav-study
#13
Mari Tinholt, Øystein Garred, Elin Borgen, Elsa Beraki, Ellen Schlichting, Vessela Kristensen, Kristine Kleivi Sahlberg, Nina Iversen
BACKGROUND: Tumor expression of certain coagulation factors have been linked to cancer progression. Single nucleotide polymorphisms (SNPs) in F5 (encoding the FV protein) have been found associated with breast cancer, however, the role of coagulation factor V (FV) in cancer pathogenesis remains undiscovered. OBJECTIVES: We aimed to investigate the clinical significance of FV and the regulatory role of F5 gene variants in breast cancer. PATIENTS/METHODS: A Scandinavian 503-sample breast cancer cohort and three public breast cancer data sets (GOBO, TCGA, and KM plotter) were used to determine associations between F5 gene expression (tumor-specific), circulating FV, F5 SNPs, clinical characteristics, and breast cancer survival...
May 16, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29765813/isolation-and-characterization-of-fusarium-wilt-resistance-gene-analogs-in-radish
#14
Xiaona Yu, Dong Hyun Kang, Su Ryun Choi, Yinbo Ma, Lu Lu, Sang Heon Oh, Sushil Satish Chhapekar, Yong Pyo Lim
The resistance gene analog (RGA)-based marker strategy is an effective supplement for current marker reservoir of radish disease-resistance breeding. In this study, we identified RGAs based on the conserved nucleotide-binding site (NBS) and S-receptor-like kinase (SRLK) domains. A total of 68 NBS-RGAs and 46 SRLK-RGAs were isolated from two FW-resistant radish inbred lines, B2 and YR31, and one susceptible line, YR15. A BLASTx search revealed that the NBS-RGAs contained six conserved motifs (i.e., P loop, RNBS-A, Kinase-2, RNBS-B, RNBS-C, and GLPL) and the SRLK-RGAs, contained two conserved motifs (i...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29765250/genetic-variants-in-the-exon-region-of-versican-predict-survival-of-patients-with-resected-early-stage-hepatitis-b-virus-associated-hepatocellular-carcinoma
#15
Xiaoguang Liu, Chuangye Han, Xiwen Liao, Long Yu, Guangzhi Zhu, Hao Su, Wei Qin, Sicong Lu, Xinping Ye, Tao Peng
Background: The upregulated expression of versican (VCAN) promotes the proliferation, invasion, and metastasis of various types of human cancer cells, including hepatocellular carcinoma (HCC) cells. Patients and methods: In this study, genetic variants in the exon region of VCAN were genotyped by DNA sequencing. Prognostic values of VCAN exon single nucleotide polymorphisms (SNPs) were assessed by Kaplan-Meier with the log-rank test, and uni- and multivariate Cox proportional hazard regression model...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29764553/-interposed-abdominal-pulling-pressing-cardiopulmonary-resuscitation-improve-the-resuscitation-effect-for-patients-with-cardiac-arrest
#16
Dabing Wang, Xiaonan Feng, Yujuan Han
OBJECTIVE: To study the impact of interposed abdominal pulling-pressing cardiopulmonary resuscitation (IAPP-CPR) for patients with cardiac arrest (CA). METHODS: A prospective study was conducted. A total of 122 CA patients admitted to Department of Emergency of Shandong Provincial Mining Industry Group Company Central Hospital from July 2013 to December 2017 were enrolled. They were divided into standard cardiopulmonary resuscitation (S-CPR) group (n = 62) and IAPP-CPR group (n = 60) according to order of admission...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764514/integrative-analysis-of-gene-expression-profiles-reveals-specific-signaling-pathways-associated-with-pancreatic-duct-adenocarcinoma
#17
Jun Li, Wenle Tan, Linna Peng, Jialiang Zhang, Xudong Huang, Qionghua Cui, Jian Zheng, Wen Tan, Chen Wu, Dongxin Lin
BACKGROUND: Pancreatic duct adenocarcinoma (PDAC) remains a major health problem because conventional cancer treatments are relatively ineffective against it. Microarray studies have linked many genes to pancreatic cancer, but the available data have not been extensively mined for potential insights into PDAC. This study attempted to identify PDAC-associated genes and signaling pathways based on six microarray-based profiles of gene expression in pancreatic cancer deposited in the gene expression omnibus database...
April 27, 2018: Cancer communications
https://www.readbyqxmd.com/read/29763853/text-mining-and-network-analysis-to-find-functional-associations-of-genes-in-high-altitude-diseases
#18
Balu Bhasuran, Devika Subramanian, Jeyakumar Natarajan
BACKGROUND AND OBJECTIVES: Travel to elevations above 2500 m is associated with the risk of developing one or more forms of acute altitude illness such as acute mountain sickness (AMS), high altitude cerebral edema (HACE) or high altitude pulmonary edema (HAPE). Our work aims to identify the functional association of genes involved in high altitude diseases. METHOD: In this work we identified the gene networks responsible for high altitude diseases by using the principle of gene co-occurrence statistics from literature and network analysis...
May 2, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29762787/litvar-a-semantic-search-engine-for-linking-genomic-variant-data-in-pubmed-and-pmc
#19
Alexis Allot, Yifan Peng, Chih-Hsuan Wei, Kyubum Lee, Lon Phan, Zhiyong Lu
The identification and interpretation of genomic variants play a key role in the diagnosis of genetic diseases and related research. These tasks increasingly rely on accessing relevant manually curated information from domain databases (e.g. SwissProt or ClinVar). However, due to the sheer volume of medical literature and high cost of expert curation, curated variant information in existing databases are often incomplete and out-of-date. In addition, the same genetic variant can be mentioned in publications with various names (e...
May 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29761859/systematic-analyses-of-a-novel-lncrna-associated-signature-as-the-prognostic-biomarker-for-hepatocellular-carcinoma
#20
Jing Sui, Yan Miao, Jiali Han, Hongmei Nan, Bo Shen, Xiaomei Zhang, Yan Zhang, Yuan Wu, Wenjuan Wu, Tong Liu, Siyi Xu, Sheng Yang, Lihong Yin, Yuepu Pu, Geyu Liang
Accumulating evidence implies that long noncoding RNAs (lncRNAs) play a crucial role in predicting survival for Hepatocellular carcinoma (HCC) patients. This study aims to capture the current research hotspots of HCC, based on the analysis of publications related to HCC research from 2013 to 2017, and to identify a novel lncRNA signature for HCC prognosis through the data mining in The Cancer Genome Atlas (TCGA). "Prognosis" and "biomarker" were located in the core of the HCC research hotspot...
May 15, 2018: Cancer Medicine
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