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https://www.readbyqxmd.com/read/28934844/an-update-on-cardiomyopathies-immune-mediated-diseases-sarcoidosis-and-peripartum-and-hypertrophic-cardiomyopathies-during-pregnancy
#1
Thomas F Lüscher
No abstract text is available yet for this article.
September 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28934840/arrhythmias-at-the-munich-octoberfest-ecg-under-the-influence
#2
Moritz F Sinner, Stefan Brunner
No abstract text is available yet for this article.
September 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28934822/stent-placement-for-benign-esophageal-leaks-perforations-and-fistulae-a-clinical-prediction-rule-for-successful-leakage-control
#3
Emo E van Halsema, Wouter F W Kappelle, Bas L A M Weusten, Robert Lindeboom, Mark I van Berge Henegouwen, Paul Fockens, Frank P Vleggaar, Manon C W Spaander, Jeanin E van Hooft
Background and study aims Sealing esophageal leaks by stent placement allows healing in 44 % - 94 % of patients. We aimed to develop a prediction rule to predict the chance of successful stent therapy. Patients and methods In this multicenter retrospective cohort study, patients with benign upper gastrointestinal leakage treated with stent placement were included. We used logistic regression analysis including four known clinical predictors of stent therapy outcome. The model performance to predict successful stent therapy was evaluated in an independent validation sample...
September 21, 2017: Endoscopy
https://www.readbyqxmd.com/read/28934810/cross-sectional-imaging-of-solitary-lesions-of-the-neurocranium
#4
Max-Ludwig Schäfer, Arend Koch, Florian Streitparth, Edzard Wiener
Background Although a wide range of processes along the neurocranium are of a benign nature, there are often difficulties in the differential diagnosis. Method In the review CT/MRI scans of the head were evaluated retrospectively regarding solitary lesions along the neurocranium. The majority of the lesions were histologically proven. Results The purpose of the review is to present typical pathologies of the neurocranium and provide a systematic overview based on 12 entities, their locations, prevalence and radiological characteristics...
September 21, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28934745/association-between-body-composition-and-motor-performance-in-preschool-children
#5
Tanja H Kakebeeke, Stefano Lanzi, Annina E Zysset, Amar Arhab, Nadine Messerli-Bürgy, Kerstin Stuelb, Claudia S Leeger-Aschmann, Einat A Schmutz, Andrea H Meyer, Susi Kriemler, Simone Munsch, Oskar G Jenni, Jardena J Puder
OBJECTIVE: Being overweight makes physical movement more difficult. Our aim was to investigate the association between body composition and motor performance in preschool children. METHODS: A total of 476 predominantly normal-weight preschool children (age 3.9 ± 0.7 years; m/f: 251/225; BMI 16.0 ± 1.4 kg/m2) participated in the Swiss Preschoolers' Health Study (SPLASHY). Body composition assessments included skinfold thickness, waist circumference (WC), and BMI...
September 22, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28934718/urinary-bpa-and-phthalate-metabolite-concentrations-and-plasma-vitamin-d-levels-in-pregnant-women-a-repeated-measures-analysis
#6
Lauren E Johns, Kelly K Ferguson, David E Cantonwine, Thomas F McElrath, Bhramar Mukherjee, John D Meeker
BACKGROUND: In addition to its well-established role in maintaining skeletal health, vitamin D has essential regulatory functions in female reproductive and pregnancy outcomes. Phthalates and bisphenol A (BPA) are endocrine disruptors, and previous research has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults. OBJECTIVES: We investigated the relationships between repeated measures of urinary phthalate metabolites and BPA and circulating total 25(OH)D in a prospective cohort of pregnant women...
August 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934699/pseudopotential-calculations-of-alsb-under-pressure
#7
H Algarni, O A Al-Hagan, N Bouarissa, M A Khan, T F Alhuwaymel
The dependence on hydrostatic pressure of the electronic and optical properties of zinc-blende AlSb semiconducting material in the pressure range of 0-20kbar has been reported using a pseudopotential approach. At zero pressure, our findings showed that the electron and heavy hole effective masses are 0.11 and 0.38m0, respectively. Moreover, our results yielded values of 3.3289 and 11.08 for refractive index and high frequency dielectric constant, respectively. These results are found to be in good accord with experiment...
September 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28934686/changes-in-microbial-community-during-removal-of-bde-153-in-four-types-of-aquatic-sediments
#8
Ying Pan, Juan Chen, Haichao Zhou, Nora F Y Tam
Indigenous microorganisms in sediments could degrade polybrominated diphenyl ethers (PBDEs), but how the microbial communities respond to PBDEs was seldom reported. The effect of BDE-153, a common congener in aquatic environments, on the microbial communities in four types of aquatic sediments was evaluated during the 150days' incubation under an anaerobic condition. The intrinsic potential to remove BDE-153 varied significantly among four sediment types, and the removal rates of mangrove, mudflat, marine and freshwater sediments were 0...
September 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28934684/scientific-evidence-for-the-identification-of-an-aboriginal-massacre-at-the-sturt-creek-sites-on-the-kimberley-frontier-of-north-western-australia
#9
Pamela A Smith, Mark D Raven, Keryn Walshe, Robert W Fitzpatrick, F Donald Pate
Archival research into episodes of frontier violence in the Kimberley region of Western Australia indicate that the bodies of Aboriginal victims of massacres were frequently incinerated following the event. This paper presents the results of a scientific investigation of a reported massacre at Sturt Creek where burnt bone fragments were identified in two adjacent sites and documents the archaeological signatures associated with the sites. The methodology used to undertake the project brought together three systems of knowledge: the oral testimonies of the descent group originating from a sole adult survivor of the massacre; archival, historical and scientific research...
August 31, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28934666/behavioral-approach-and-orbitofrontal-cortical-activity-during-decision-making-in-substance-dependence
#10
Dorothy J Yamamoto, Marie T Banich, Michael F Regner, Joseph T Sakai, Jody Tanabe
Behavioral approach, defined as behavior directed toward a reward or novel stimulus, when elevated, may increase one's vulnerability to substance use disorder. Behavioral approach has been associated with relatively greater left compared to right frontal activity; behavioral inhibition may be associated with relatively greater right compared to left frontal brain activity. We hypothesized that substance dependent individuals (SDI) would have higher behavioral approach than controls and greater prefrontal cortical activity during decision-making involving reward...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28934663/using-a-fluorescence-quenching-method-to-detect-dna-adsorption-onto-single-walled-carbon-nanotube-surfaces
#11
Kazuo Umemura, Shizuma Sato, Gilbert Bustamante, Jing Yong Ye
Surface modification of single-walled carbon nanotubes (SWNTs) with DNA molecules has attracted much attention in recent years to increase SWNT solubility and make various SWNT-based nanobiodevices. Therefore, there is a critical need to quantify the interaction between DNA molecules and SWNT surfaces, particularly the intermediate structures during DNA adsorption. In this study, we demonstrate the ability to detect the adsorption of DNA oligomers on SWNT surfaces by fluorescence spectroscopy. Fluorescein-labelled, 30mer, thymine oligonucleotides (F-T30) were employed as a fluorescent probe to study the interaction of DNA with SWNTs...
September 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28934649/cooperative-stimulation-of-atherogenesis-by-lipopolysaccharide-and%C3%A2-palmitic-acid-rich-high-fat-diet-in-low-density-lipoprotein-receptor-deficient-mice
#12
Zhongyang Lu, Yanchun Li, Colleen W Brinson, Maria F Lopes-Virella, Yan Huang
BACKGROUND AND AIMS: Either lipopolysaccharide (LPS) or high-fat diet (HFD) enriched with saturated fatty acid (SFA) promotes atherosclerosis. In this study, we investigated the effect of LPS in combination with SFA-rich HFD on atherosclerosis and how LPS and SFA interact to stimulate inflammatory response in vascular endothelial cells. METHODS: Low-density lipoprotein receptor-deficient (LDLR(-/-)) mice were fed a low-fat diet (LFD), HFD with low palmitic acid (PA) (LP-HFD), or HFD with high PA (HP-HFD) for 20 weeks...
September 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28934619/distinct-brain-metabolic-patterns-separately-associated-with-cognition-motor-function-and-aging-in-parkinson-s-disease-dementia
#13
Ji Hyun Ko, Audrey Katako, Maram Aljuaid, Andrew L Goertzen, Andrew Borys, Douglas E Hobson, Seok Min Kim, Chong Sik Lee
We explored whether patients with Parkinson's disease dementia (PDD) show a distinct spatial metabolic pattern that characterizes cognitive deficits in addition to motor dysfunction. Eighteen patients with PDD underwent 3 separate positron emission tomography sessions with [(18)F]fluorodeoxyglucose (for glucose metabolism), fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane (for dopamine transporter density) and Pittsburgh compound-B (for beta-amyloid load). We confirmed in PDD versus normal controls, overall hypometabolism in the posterior and prefrontal brain regions accompanied with hypermetabolism in subcortical structures and the cerebellar vermis...
August 31, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28934589/low-dietary-protein-and-high-carbohydrate-infant-formula-affects-the-microbial-ecology-of-the-large-intestine-in-neonatal-rats
#14
Wenguang Fan, Haiwei Ren, Yingying Cao, Yonggang Wang, Guicheng Huo
The aim of this study was to investigate the effects of a low dietary protein and high carbohydrate infant formula on the large intestine of neonatal rats. A total of 24 neonatal SD rats (14d old) were randomly assigned to the low-protein, high-carbohydrate infant formula-fed group (IF group) and a human breast milk-fed group (HF group). After 7 days, we selected 6 rats at random from each group to study. No significantly different microbial colonization patterns were observed in the two groups at the phylum level...
September 21, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28934523/sleep-stage-transition-dynamics-reveal-specific-stage-2-vulnerability-in-insomnia
#15
Yishul Wei, Michele A Colombo, Jennifer R Ramautar, Tessa F Blanken, Ysbrand D van der Werf, Kai Spiegelhalder, Bernd Feige, Dieter Riemann, Eus J W Van Someren
Study Objectives: Objective sleep impairments in insomnia disorder (ID) are insufficiently understood. The present study evaluated whether whole-night sleep stage dynamics derived from polysomnography (PSG) differ between people with ID and matched controls and whether sleep stage dynamic features discriminate them better than conventional sleep parameters. Methods: Eighty-eight participants aged 21-70 years, including 46 with ID and 42 age- and sex-matched controls without sleep complaints, were recruited through www...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28934512/increased-patient-satisfaction-and-a-reduction-in-pre-analytical-errors-following-implementation-of-an-electronic-specimen-collection-module-in-outpatient-phlebotomy
#16
Michalis Kantartjis, Stacy E F Melanson, Athena K Petrides, Adam B Landman, David W Bates, Bernard A Rosner, Ellen Goonan, Ida Bixho, Milenko J Tanasijevic
Background: Patient satisfaction in outpatient phlebotomy settings typically depends on wait time and venipuncture experience, and many patients equate their experiences with their overall satisfaction with the hospital. Methods: We compared patient service times and preanalytical errors pre- and postimplementation of an integrated electronic health record (EHR)-laboratory information system (LIS) and electronic specimen collection module. We also measured patient wait time and assessed patient satisfaction using a 5-question survey...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28934505/combining-asymmetric-13c-labeling-and-isotopic-filter-edit-noesy-a-novel-strategy-for-rapid-and-logical-rna-resonance-assignment
#17
Regan M LeBlanc, Andrew P Longhini, Stuart F J Le Grice, Bruce A Johnson, Theodore K Dayie
Although ∼98% of the human genomic output is transcribed as non-protein coding RNA, <2% of the protein data bank structures comprise RNA. This huge structural disparity stems from combined difficulties of crystallizing RNA for X-ray crystallography along with extensive chemical shift overlap and broadened linewidths associated with NMR of RNA. While half of the deposited RNA structures in the PDB were solved by NMR methods, the usefulness of NMR is still limited by the high cost of sample preparation and challenges of resonance assignment...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934499/co-produced-natural-ketolides-methymycin-and-pikromycin-inhibit-bacterial-growth-by-preventing-synthesis-of-a-limited-number-of-proteins
#18
Mashal M Almutairi, Maxim S Svetlov, Douglas A Hansen, Nelli F Khabibullina, Dorota Klepacki, Han-Young Kang, David H Sherman, Nora Vázquez-Laslop, Yury S Polikanov, Alexander S Mankin
Antibiotics methymycin (MTM) and pikromycin (PKM), co-produced by Streptomyces venezuelae, represent minimalist macrolide protein synthesis inhibitors. Unlike other macrolides, which carry several side chains, a single desosamine sugar is attached to the macrolactone ring of MTM and PKM. In addition, the macrolactone scaffold of MTM is smaller than in other macrolides. The unusual structure of MTM and PKM and their simultaneous secretion by S. venezuelae bring about the possibility that two compounds would bind to distinct ribosomal sites...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934486/stn1-pola2-interaction-provides-a-basis-for-primase-pol-%C3%AE-stimulation-by-human-stn1
#19
Swapna Ganduri, Neal F Lue
The CST (CTC1-STN1-TEN1) complex mediates critical functions in maintaining telomere DNA and overcoming genome-wide replication stress. A conserved biochemical function of the CST complex is its primase-Pol α (PP) stimulatory activity. In this report, we demonstrate the ability of purified human STN1 alone to promote PP activity in vitro. We show that this regulation is mediated primarily by the N-terminal OB fold of STN1, but does not require the DNA-binding activity of this domain. Rather, we observed a strong correlation between the PP-stimulatory activity of STN1 variants and their abilities to bind POLA2...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934461/effect-of-priming-with-seasonal-influenza-a-h3n2-virus-on-the-prevalence-of-cross-reactive-hemagglutination-inhibition-antibodies-to-swine-origin-a-h3n2-variants
#20
Feng Liu, Vic Veguilla, F Liaini Gross, Eric Gillis, Thomas Rowe, Xiyan Xu, Terrence M Tumpey, Jacqueline M Katz, Min Z Levine, Xiuhua Lu
Background: Recent outbreaks of swine-origin influenza A(H3N2) variant (H3N2v) viruses have raised public health concerns. Previous studies indicated that older children and young adults had the highest levels of hemagglutination-inhibition (HI) antibodies to 2010-2011 H3N2v viruses. However, newly emerging 2013 H3N2v have acquired antigenic mutations in the hemagglutinin at amino acid position 145 (N145K/R). We estimated the levels of serologic cross-reactivity among humans primed with seasonal influenza A(H3N2) (sH3N2), using postinfection ferret antisera...
September 15, 2017: Journal of Infectious Diseases
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