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https://www.readbyqxmd.com/read/28821199/keratin-17-is-a-prognostic-biomarker-in-endocervical-glandular-neoplasia
#1
Daniel Mockler, Luisa F Escobar-Hoyos, Ali Akalin, Jamie Romeiser, A Laurie Shroyer, Kenneth R Shroyer
Objectives: Previous work in our laboratory identified keratin 17 (K17) as a specific and sensitive biomarker for high-grade squamous intraepithelial lesions and cervical squamous cell carcinoma (SCC). K17, however, has not been previously evaluated in endocervical glandular neoplasia. Based on the similar pathogenesis of squamous and glandular lesions of the cervix, we hypothesized that K17 overexpression could also be a diagnostic and/or prognostic biomarker for endocervical neoplasia...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28821194/primary-benign-and-malignant-thyroid-neoplasms-with-signet-ring-cells-cytologic-histologic-and-molecular-features
#2
Nada A Farhat, Ayse M Onenerk, Jeffrey F Krane, Dora Dias-Santagata, Peter M Sadow, William C Faquin
Objectives: Signet ring cells (SRCs) can be seen in a variety of thyroid tumors and can pose a diagnostic pitfall on cytology. This study describes the cytologic, histomorphologic, and molecular aspects of a cohort of primary thyroid tumors with SRCs. Methods: A search was performed of the Massachusetts General Hospital and Brigham and Women's Hospital (Boston, MA) pathology archives for the keywords thyroid, signet, and signet ring features between 2000 and 2014...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28821188/panmixia-and-limited-interspecific-introgression-in-coyotes-canis-latrans-from-west-virginia-and-virginia-usa
#3
Justin H Bohling, Lauren L Mastro, Jennifer R Adams, Eric M Gese, Sheldon F Owen, Lisette P Waits
The expansion of coyotes (Canis latrans) into the eastern United States has had major consequences for ecological communities and wildlife managers. Despite this, there has been little investigation of the genetics of coyotes across much of this region, especially outside of the northeast. Understanding patterns of genetic structure and interspecific introgression would provide insights into the colonization history of the species, its response to the modern environment, and interactions with other canids. We examined the genetic characteristics of 121 coyotes from the mid-Atlantic states of West Virginia and Virginia by genotyping 17 polymorphic nuclear DNA microsatellite loci...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28821177/perioperative-care-of-cardiac-patients-preventing-myocardial-injury-bleeding-and-death
#4
Thomas F Lüscher
No abstract text is available yet for this article.
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28821142/manufacture-of-requeij%C3%A3-o-cremoso-processed-cheese-with-galactooligosaccharide
#5
P C Belsito, M V S Ferreira, L P Cappato, R N Cavalcanti, V A S Vidal, T C Pimentel, E A Esmerino, C F Balthazar, R P C Neto, M I B Tavares, P B Zacarchenco, M Q Freitas, M C Silva, R S L Raices, G M Pastore, M A R Pollonio, A G Cruz
The addition of galactooligosaccharide, (GOS, 0, 1.5, 3 or 4g/100g) on the quality parameters of requeijão cremoso was investigated. Chemical characteristics (pH, moisture, fat and protein), color (L*, a*, b*), water mobility by TD- nuclear magnetic resonance, rheology (flow curve and oscillatory tests), microstructure and sensory acceptance (consumer test) were evaluated. The addition of GOS provided a denser and compact structure and reduced number and size of fat globules. Increased GOS level (3 and 4g/100g) improved the softness and spreadability (decrease of G', G″ and apparent viscosity and an increase of tan δ and melting index) and impacted positively on the aroma and taste of the requeijão cremoso...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821140/the-potential-of-cashew-gum-functionalization-as-building-blocks-for-layer-by-layer-films
#6
Álvaro J Leite, Rui R Costa, Ana M S Costa, Jeanny S Maciel, José F G Costa, Regina C M de Paula, João F Mano
Cashew gum (CG), an exudate polysaccharide from Anacardium occidentale trees, was carboxymethylated (CGCm) and oxidized (CGO). These derivatives were characterized by FTIR and zeta potential measurements confirming the success of carboxymethylation and oxidation reactions. Nanostructured multilayered films were then produced through layer-by-layer (LbL) assembly in conjugation with chitosan via electrostatic interactions or Schiff bases covalent bonds. The films were analyzed by QCM-D and AFM. CG functionalization increased the film thickness, with the highest thickness being achieved for the lowest oxidation degree...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821098/physical-chemical-characteristics-and-potential-use-of-a-novel-alginate-zein-hydrogel-as-the-sorption-phase-for-polar-organic-compounds
#7
Natara D B Castilhos, Naiara M F M Sampaio, Bruno C da Silva, Izabel C Riegel-Vidotti, Marco T Grassi, Bruno J G Silva
A novel alginate based hydrogel was successfully prepared and tested for the solid phase microextraction of medium-to-high polarity compounds, when supported in a polypropylene (PP) fiber. Pure alginate when added onto the surface of the PP fiber, resulted in a significant improvement in the extraction efficiency of the analytes (except for β-estradiol). The alginate hydrogel was modified upon the incorporation of a small amount of zein, a corn protein. Interestingly, the alginate/zein-supported hydrogel was capable of successfully extracting compounds with low partition constant (Kow), such as 17-α-ethinyl estradiol, progesterone and estriol, since the initial water uptake decreased dramatically in this gel, therefore, leaving the alginate hydroxyl groups more available to interact with the polar compounds...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821016/expression-of-interferon-inducible-chemokines-and-sleep-wake-changes-during-early-encephalitis-in-experimental-african-trypanosomiasis
#8
Claudia Laperchia, Chiara Tesoriero, Paul F Seke-Etet, Valentina La Verde, Valeria Colavito, Gigliola Grassi-Zucconi, Jean Rodgers, Paul Montague, Peter G E Kennedy, Marina Bentivoglio
BACKGROUND: Human African trypanosomiasis or sleeping sickness, caused by the parasite Trypanosoma brucei, leads to neuroinflammation and characteristic sleep/wake alterations. The relationship between the onset of these alterations and the development of neuroinflammation is of high translational relevance, but remains unclear. This study investigates the expression of interferon (IFN)-γ and IFN-inducible chemokine genes in the brain, and the levels of CXCL10 in the serum and cerebrospinal fluid prior to and during the encephalitic stage of trypanosome infection, and correlates these with sleep/wake changes in a rat model of the disease...
August 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28821013/rictor-positively-regulates-b-cell-receptor-signaling-by-modulating-actin-reorganization-via-ezrin
#9
Lu Huang, Yongjie Zhang, Chenguang Xu, Xiaomei Gu, Linlin Niu, Jinzhi Wang, Xiaoyu Sun, Xiaoming Bai, Xingtian Xuan, Qubei Li, Chunwei Shi, Bing Yu, Heather Miller, Gangyi Yang, Lisa S Westerberg, Wanli Liu, Wenxia Song, Xiaodong Zhao, Chaohong Liu
As the central hub of the metabolism machinery, the mammalian target of rapamycin complex 2 (mTORC2) has been well studied in lymphocytes. As an obligatory component of mTORC2, the role of Rictor in T cells is well established. However, the role of Rictor in B cells still remains elusive. Rictor is involved in B cell development, especially the peripheral development. However, the role of Rictor on B cell receptor (BCR) signaling as well as the underlying cellular and molecular mechanism is still unknown. This study used B cell-specfic Rictor knockout (KO) mice to investigate how Rictor regulates BCR signaling...
August 2017: PLoS Biology
https://www.readbyqxmd.com/read/28820988/integrating-printed-microfluidics-with-silicon-photomultipliers-for-miniaturised-and-highly-sensitive-atp-bioluminescence-detection
#10
M F Santangelo, S Libertino, A P F Turner, D Filippini, W C Mak
Bioluminescence has been widely used for important biosensing applications such as the measurement of adenosine triphosphate (ATP), the energy unit in biological systems and an indicator of vital processes. The current technology for detection is mainly based on large equipment such as readers and imaging systems, which require intensive and time-consuming procedures. A miniaturised bioluminescence sensing system, which would allow sensitive and continuous monitoring of ATP, with an integrated and low-cost disposable microfluidic chamber for handling of biological samples, is highly desirable...
July 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28820959/takinib-a-selective-tak1-inhibitor-broadens-the-therapeutic-efficacy-of-tnf-%C3%AE-inhibition-for-cancer-and-autoimmune-disease
#11
Juliane Totzke, Deepak Gurbani, Rene Raphemot, Philip F Hughes, Khaldon Bodoor, David A Carlson, David R Loiselle, Asim K Bera, Liesl S Eibschutz, Marisha M Perkins, Amber L Eubanks, Phillip L Campbell, David A Fox, Kenneth D Westover, Timothy A J Haystead, Emily R Derbyshire
Tumor necrosis factor alpha (TNF-α) has both positive and negative roles in human disease. In certain cancers, TNF-α is infused locally to promote tumor regression, but dose-limiting inflammatory effects limit broader utility. In autoimmune disease, anti-TNF-α antibodies control inflammation in most patients, but these benefits are offset during chronic treatment. TAK1 acts as a key mediator between survival and cell death in TNF-α-mediated signaling. Here, we describe Takinib, a potent and selective TAK1 inhibitor that induces apoptosis following TNF-α stimulation in cell models of rheumatoid arthritis and metastatic breast cancer...
August 17, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28820949/association-between-patient-factors-and-outcome-of-synthetic-cartilage-implant-hemiarthroplasty-vs-first-metatarsophalangeal-joint-arthrodesis-in-advanced-hallux-rigidus
#12
Andy Goldberg, Dishan Singh, Mark Glazebrook, Chris M Blundell, Gwyneth De Vries, Ian L D Le, Dominic Nielsen, M Elizabeth Pedersen, Anthony Sakellariou, Matthew Solan, Alastair S E Younger, Timothy R Daniels, Judith F Baumhauer
BACKGROUND: We evaluated data from a clinical trial of first metatarsophalangeal joint (MTPJ1) implant hemiarthroplasty and arthrodesis to determine the association between patient factors and clinical outcomes. METHODS: Patients ≥18 years with hallux rigidus grade 2, 3, or 4 were treated with synthetic cartilage implant MTPJ1 hemiarthroplasty or arthrodesis. Pain visual analog scale (VAS), Foot and Ankle Ability Measure (FAAM) sports and activities of daily living (ADL) scores, and Short Form-36 Physical Function (SF-36 PF) subscore were obtained preoperatively, and at 2, 6, 12, 24, 52, and 104 weeks postoperatively...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28820945/a-chiral-gas-hydrate-structure-common-to-the-carbon-dioxide-water-and-hydrogen-water-systems
#13
Dan Amos, Mary-Ellen Donnelly, Pattanasak Teeratchanan, Craig L Bull, Andrzej Falenty, Werner F Kuhs, Andreas Hermann, John Loveday
We present diffraction studies and full in-situ structural solutions of carbon dioxide hydrate-II and hydrogen hydrate $C_0$ at elevated pressures. We find both hydrates adopt a common water network structure. The structure exhibits several features not previously found in hydrates, most notably it is chiral and has large open spiral channels along which the guest molecules are free to move. It has a network that is unrelated to any experimentally known ice, silica or zeolite network but is instead related to two Zintl compounds...
August 18, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28820935/accelerating-palladium-nanowire-h2-sensors-using-engineered-nanofiltration
#14
Won-Tae Koo, Shaopeng Qiao, Alana F Ogata, Gaurav Jha, Ji-Soo Jang, Vivian T Chen, Il-Doo Kim, Reginald M Penner
The oxygen, O2, in air interferes with the detection of H2 by palladium (Pd)-based H2 sensors, including Pd nanowires (NWs), depressing the sensitivity and retarding the response/recovery speed in air - relative to N2 or Ar. Here, we describe the preparation of H2 sensors in which a nanofiltration layer consisting of a Zn metal-organic-framework (MOF) is assembled onto Pd NWs. Polyhedron particles of Zn based zeolite imidazole framework (ZIF-8) were synthesized on lithographically patterned Pd NWs, leading to the creation of ZIF-8/Pd NWs bi-layered H2 sensors...
August 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28820932/titanium-oxynitride-thin-films-with-tuneable-double-epsilon-near-zero-behaviour-for-nanophotonic-applications
#15
Laurentiu Braic, Nikolaos Vasilantonakis, Andrei Mihai, Ignacio Jose Villar-Garcia, Sarah Fearn, Bin Zou, Neil McN Alford, Brock Doiron, Rupert F Oulton, Stefan A Maier, Anatoly V Zayats, Peter K Petrov
Titanium Oxynitride (TiOxNy) thin films are fabricated using reactive magnetron sputtering. The mechanism of their growth formation is explained and their optical properties are presented. The films grown when the level of residual Oxygen in the background vacuum was between 5 nTorr to 20 nTorr exhibit double Epsilon-Near- Zero (2-ENZ) behaviour with ENZ1 and ENZ2 wavelengths tunable in the 700-850 nm and in the 1100-1350 nm spectral ranges, respectively. Samples fabricated when the level of residual Oxygen in the background vacuum was above 2E-8Torr exhibit non- metallic behaviour, while the layers deposited when the level of residual Oxygen in the background vacuum was below 5E-9Torr, show metallic behaviour with a single ENZ value...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28820906/exposure-to-fine-particulate-matter-in-the-air-alters-placental-structure-and-the-renin-angiotensin-system
#16
Sônia de Fátima Soto, Juliana Oliveira de Melo, Guilherme D'Aprile Marchesi, Karen Lucasechi Lopes, Mariana Matera Veras, Ivone Braga de Oliveira, Regiane Machado de Souza, Isac de Castro, Luzia Naôko Shinohara Furukawa, Paulo Hilário Nascimento Saldiva, Joel C Heimann
METHODS: Female Wistar rats were exposed to filtered air (F) or to concentrated fine particulate matter (P) for 15 days. After mating, the rats were divided into four groups and again exposed to F or P (FF, FP, PF, PP) beginning on day 6 of pregnancy. At embryonic day 19, the placenta was collected. The placental structure, the protein and gene expression of TGFβ1, VEGF-A, and its receptor Flk-1 and RAS were evaluated by indirect ELISA and quantitative real-time PCR. RESULTS: Exposure to P decreased the placental mass, size, and surface area as well as the TGFβ1, VEGF-A and Flk-1 content...
2017: PloS One
https://www.readbyqxmd.com/read/28820855/resistance-exercise-order-does-not-affect-the-magnitude-and-duration-of-post-exercise-blood-pressure-in-older-women
#17
Crisieli M Tomeleri, João Pedro Nunes, Mariana F Souza, Aline Gerage, Alexandre Marcori, Kessi Cassiane Iarosz, Crivaldo Gomes Cardoso-Júnior, Edilson S Cyrino
The aim of this study was to compare the effects of two resistance exercise order on post-exercise blood pressure (BP) in trained, non-hypertensive older women. Sixteen women (68.3 ± 3.3 years, 63.5 ± 11.6 kg, 157.5 ± 5.1 cm) performed two sessions witheight exercises (3 sets of 8-12 repetitions) in distinct orders (from multi- to single-joint exercises [MS] or from single- to multi-joint exercises [SM]) and a control session, without exercise. Blood pressure and heart rate were obtained pre and post-sessions (60 min)...
August 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28820850/ultrasonographic-findings-in-the-vitreous-of-patients-with-age-related-macular-degeneration-treated-with-intravitreal-anti-vascular-endothelial-growth-factor-injections
#18
Tamara Mato-Gondelle, Manuel F Bande, Laura Paniagua, María J Rodríguez-Cid, Maximino Abraldes, Maribel Fernández, María J Blanco-Teijeiro, Antonio Piñeiro
PURPOSE: We aimed to assess the relationship of repeated intravitreal injection of anti-vascular endothelial growth factor, the main treatment for exudative age-related macular degeneration, with changes in vitreous ultrasonographic findings in patients with age-related macular degeneration. METHODS: We retrospectively collected data from 41 patients (41 age-related macular degeneration eyes, 41 control eyes) on age, sex, number of injections, and type of anti-vascular endothelial growth factor (ranibizumab, aflibercept)...
August 16, 2017: Retina
https://www.readbyqxmd.com/read/28820847/effectiveness-of-a-16-week-high-intensity-cardioresistance-training-program-in-adults
#19
Tina A Greenlee, Daniel R Greene, Nathan J Ward, Ginger E Reeser, Courtney M Allen, Nicholas W Baumgartner, Neal J Cohen, Arthur F Kramer, Charles H Hillman, Aron K Barbey
Greenlee, TA, Greene, DR, Ward, NJ, Reeser, GE, Allen, CM, Baumgartner, NW, Cohen, NJ, Kramer, AF, Hillman, CH, and Barbey, AK. Effectiveness of a 16-week high-intensity cardioresistance training program in adults. J Strength Cond Res 31(9): 2528-2541, 2017-The purpose of this study was to determine the efficacy of a novel, 16-week high-intensity cardioresistance training (HICRT) program on measures of aerobic fitness, agility, aerobic power, muscular endurance, lower-body explosive power, and self-reported activity level...
September 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28820836/the-surgeon-s-fist-with-the-thumb-up-to-guide-the-design-and-inset-of-the-osteoseptocutaneous-fibula-flap-in-mandibular-reconstruction
#20
Nidal F Al Deek, Chung-Kan Tsao, Fu-Chan Wei
Successful reconstruction of the oromandibular defect with the osteoseptocutaneous fibula flap necessitates flawless design and inset, an experience-demanding endeavor. Laterality of the fibula flap has been thought to pose a certain challenge to the reconstruction. To address this concern and guide flap design and inset, the authors propsed using the surgeon's fist with the thumb up to replicate key anatomic land marks of the fibula flap: the peroneal vessels and proximal bone end, the posterior crural septum including the septal vessels, the skin, and the lateral surface of the fibula bone...
August 8, 2017: Plastic and Reconstructive Surgery
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