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https://www.readbyqxmd.com/read/28934836/pregnancy-in-women-with-hypertrophic-cardiomyopathy-data-from-the-european-society-of-cardiology-initiated-registry-of-pregnancy-and-cardiac-disease-ropac
#1
S Goland, I M van Hagen, G Elbaz-Greener, U Elkayam, A Shotan, W M Merz, S C Enar, I R Gaisin, P G Pieper, M R Johnson, R Hall, A Blatt, J W Roos-Hesselink
Aims: We report the maternal and foetal outcomes at birth and after 6 months in a cohort of pregnant women with hypertrophic cardiomyopathy (HCM). Although most women with HCM tolerate pregnancy well, there is an increased risk of obstetric and cardiovascular complications. Methods and results: All pregnant women with HCM entered into the prospective worldwide Registry of Pregnancy and Cardiac disease (ROPAC) were included in this analysis. The primary endpoint was a major adverse cardiovascular event (MACE), which included death, heart failure (HF), thrombo-embolic event, and arrhythmia...
September 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28934826/-endoscopic-treatment-of-gastric-adenoma
#2
REVIEW
Cheal Wung Huh, Byung Wook Kim
Gastric adenoma (dysplasia) is a precancerous lesion. Therefore, managements of gastric adenomas are important for preventing the development of gastric cancers and for detecting gastric cancers at earlier stages. The Vienna classification divides gastric adenomas into two categories: high-grade dysplasia and low-grade dysplasia. Generally, endoscopic resection is performed for adenoma with high-grade dysplasia due to the coexistence of carcinoma and the potential of progression to carcinomas. However, the treatments of adenoma with low-grade dysplasia remain controversial...
September 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28934823/comprehensive-analysis-of-non-synonymous-natural-variants-of-g-protein-coupled-receptors
#3
Hee Ryung Kim, Nguyen Minh Duc, Ka Young Chung
G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are the most commonly used therapeutic target. It has been suggested that GPCRs undergo massive genetic variations such as genetic polymorphisms and DNA insertions or deletions. Among these genetic variations, non-synonymous natural variations change the amino acid sequence and could thus alter GPCR functions such as expression, localization, signaling, and ligand binding, which may be involved in disease development and altered responses to GPCR-targeting drugs...
September 19, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28934821/feasibility-of-a-complete-pancreatobiliary-linear-endoscopic-ultrasound-examination-from-the-stomach
#4
Vinay Dhir, Douglas G Adler, Nonthalee Pausawasdi, Amit Maydeo, Khek Yu Ho
Background and study aims Linear endoscopic ultrasound (EUS) evaluation of the pancreaticobiliary system usually requires scanning from both the stomach and the duodenum. The feasibility of assessing the complete pancreaticobiliary system from the stomach alone has not been studied. We aimed to conceptualize a system-based approach (the railroad approach) for linear pancreaticobiliary EUS (PB-EUS) and evaluate whether the pancreaticobiliary anatomy could be assessed from the stomach alone. Patients and methods Three maneuvers were conceptualized and evaluated (the alpha maneuver in the stomach, and sigma and xi maneuvers in the duodenum)...
September 21, 2017: Endoscopy
https://www.readbyqxmd.com/read/28934795/comparisons-of-lesion-volumes-and-shapes-produced-by-a-radiofrequency-system-with-a-cooled-a-protruding-or-a-monopolar-probe
#5
David L Cedeno, Alejandro Vallejo, Courtney A Kelley, Dana M Tilley, Nitesh Kumar
BACKGROUND: Radiofrequency (RF) ablation for denervation has been utilized for decades in chronic pain management. This relies on the proper targeting of the affected nerve which may be obtained by creating an ablation lesion with a shape and volume that optimizes targeting. Various systems designed to improve lesion size are available. These include cooling the active tip (cooled-RF) and protruding the RF electrode outside the active tip (PERF). OBJECTIVES: This study compares lesion volumes of 3 commercially available RF systems: cooled-RF, "V" shaped active cannula and protruding electrode (18 g and 20 g), and monopolar RF (MRF; 16 g, 18 g, and 20 g)...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934782/the-dose-dependent-effects-of-ketoprofen-on-dynamic-pain-after-open-heart-surgery
#6
Vedat Eljezi, Claire Biboulet, Henri Boby, Pierre Schoeffler, Bruno Pereira, Christian Duale
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) can reduce postoperative pain, in both static (i.e., at rest) and dynamic contexts (e.g., during coughing or mobilization), and reduced doses could improve their efficacy/tolerance balance. OBJECTIVES: To test this hypothesis of efficacy after open heart surgery, in which NSAIDs are poorly used, particularly for safety concerns. STUDY DESIGN: Randomized, double-blind trial. SETTING: Single-center, French university hospital...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934780/efficacy-of-cannabis-based-medicines-for-pain-management-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
J Aviram, G Samuelly-Leichtag
BACKGROUND: The management of chronic pain is a complex challenge worldwide. Cannabis-based medicines (CBMs) have proven to be efficient in reducing chronic pain, although the topic remains highly controversial in this field. OBJECTIVES: This study's aim is to conduct a conclusive review and meta-analysis, which incorporates all randomized controlled trials (RCTs) in order to update clinicians' and researchers' knowledge regarding the efficacy and adverse events (AEs) of CBMs for chronic and postoperative pain treatment...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934745/association-between-body-composition-and-motor-performance-in-preschool-children
#8
Tanja H Kakebeeke, Stefano Lanzi, Annina E Zysset, Amar Arhab, Nadine Messerli-Bürgy, Kerstin Stuelb, Claudia S Leeger-Aschmann, Einat A Schmutz, Andrea H Meyer, Susi Kriemler, Simone Munsch, Oskar G Jenni, Jardena J Puder
OBJECTIVE: Being overweight makes physical movement more difficult. Our aim was to investigate the association between body composition and motor performance in preschool children. METHODS: A total of 476 predominantly normal-weight preschool children (age 3.9 ± 0.7 years; m/f: 251/225; BMI 16.0 ± 1.4 kg/m2) participated in the Swiss Preschoolers' Health Study (SPLASHY). Body composition assessments included skinfold thickness, waist circumference (WC), and BMI...
September 22, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28934744/association-of-serum-amyloid-a-with-kidney-outcomes-and-all-cause-mortality-in-american-indians-with-type-2-diabetes
#9
Pierre-Jean Saulnier, Brad P Dieter, Stephanie K Tanamas, Sterling M McPherson, Kevin M Wheelock, William C Knowler, Helen C Looker, Rick L Meek, Robert G Nelson, Katherine R Tuttle
BACKGROUND: Serum amyloid A (SAA) induces inflammation and apoptosis in kidney cells and is found to be causing the pathologic changes that are associated with diabetic kidney disease (DKD). Higher serum SAA concentrations were previously associated with increased risk of end-stage renal disease (ESRD) and death in persons with type 2 diabetes and advanced DKD. We explored the prognostic value of SAA in American Indians with type 2 diabetes without DKD or with early DKD. METHODS: SAA concentration was measured in serum samples obtained at the start of follow-up...
September 22, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28934725/prenatal-exposure-to-mercury-associations-with-global-dna-methylation-and-hydroxymethylation-in-cord-blood-and-in-childhood
#10
Andres Cardenas, Sheryl L Rifas-Shiman, Lode Godderis, Radu-Corneliu Duca, Ana Navas-Acien, Augusto A Litonjua, Dawn L DeMeo, Kasey J Brennan, Chitra J Amarasiriwardena, Marie-France Hivert, Matthew W Gillman, Emily Oken, Andrea A Baccarelli
BACKGROUND: Mercury is a global pollutant, and prenatal exposure is associated with adverse health effects. To date, no studies have evaluated the association between prenatal mercury exposure and DNA hydroxymethylation, an epigenetic modification important for tissue differentiation and embryonic development. OBJECTIVES: We sought to evaluate the association between prenatal mercury exposure and offspring global DNA methylation and hydroxymethylation at birth and test for persistence of the association in childhood...
August 29, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934718/urinary-bpa-and-phthalate-metabolite-concentrations-and-plasma-vitamin-d-levels-in-pregnant-women-a-repeated-measures-analysis
#11
Lauren E Johns, Kelly K Ferguson, David E Cantonwine, Thomas F McElrath, Bhramar Mukherjee, John D Meeker
BACKGROUND: In addition to its well-established role in maintaining skeletal health, vitamin D has essential regulatory functions in female reproductive and pregnancy outcomes. Phthalates and bisphenol A (BPA) are endocrine disruptors, and previous research has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults. OBJECTIVES: We investigated the relationships between repeated measures of urinary phthalate metabolites and BPA and circulating total 25(OH)D in a prospective cohort of pregnant women...
August 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934713/imposex-levels-and-butyltin-compounds-bts-in-hexaplex-trunculus-linnaeus-1758-from-the-northern-adriatic-sea-italy-ecological-risk-assessment-before-and-after-the-ban
#12
Federica Cacciatore, Rossella Boscolo Brusà, Seta Noventa, Camilla Antonini, Vanessa Moschino, Malgorzata Formalewicz, Claudia Gion, Daniela Berto, Massimo Gabellini, Maria Gabriella Marin
The aim of this study was to compare imposex and butyltin compounds (BTs) data, collected before and after the organotin ban in 2008, in order to assess temporal and spatial variation of the phenomenon, the decline of BT contamination, and the effects on Hexaplex trunculus population in the coastal area of the northern Adriatic Sea, close to the Venice Lagoon. Both in marine and in lagoon sites, the results obtained in 2013-2015 showed a significant decline in the incidence of imposex in respect to those from the 2002 survey...
September 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28934697/detection-of-bcg-bacteria-using-a-magnetoresistive-biosensor-a-step-towards-a-fully-electronic-platform-for-tuberculosis-point-of-care-detection
#13
Teresa G Barroso, Rui C Martins, Elisabete Fernandes, Susana Cardoso, José Rivas, Paulo P Freitas
Tuberculosis is one of the major public health concerns. This highly contagious disease affects more than 10.4 million people, being a leading cause of morbidity by infection. Tuberculosis is diagnosed at the point-of-care by the Ziehl-Neelsen sputum smear microscopy test. Ziehl-Neelsen is laborious, prone to human error and infection risk, with a limit of detection of 10(4) cells/mL. In resource-poor nations, a more practical test, with lower detection limit, is paramount. This work uses a magnetoresistive biosensor to detect BCG bacteria for tuberculosis diagnosis...
September 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28934694/development-and-implementation-of-a-pass-fail-field-friendly-method-for-detecting-sildenafil-in-suspect-pharmaceutical-tablets-using-a-handheld-raman-spectrometer-and-silver-colloids
#14
Adam Lanzarotta, Lisa Lorenz, JaCinta S Batson, Cheryl Flurer
A simple, fast, sensitive and effective pass/fail field-friendly method has been developed for detecting sildenafil in suspect Viagra and unapproved tablets using handheld Raman spectrometers and silver colloids. The method involves dissolving a portion of a tablet in water followed by filtration and addition of silver colloids, resulting in a solution that can be measured directly through a glass vial. Over one hundred counterfeit Viagra and unapproved tablets were examined on three different devices during the method development phase of the study...
September 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28934691/the-role-of-ppar-alpha-in-perfluorooctanoic-acid-induced-developmental-cardiotoxicity-and-l-carnitine-mediated-protection-results-of-in-ovo-gene-silencing
#15
Meng Zhao, Qixiao Jiang, Min Geng, Li Zhu, Yunqiu Xia, Aashish Khanal, Chunbo Wang
Perfluorooctanoic acid (PFOA) is a persistent organic pollutant. This study established an in ovo peroxisome proliferator-activated receptor alpha (PPAR alpha) silencing model in chicken embryo heart, and investigated the role of PPAR alpha in PFOA induced developmental cardiotoxicity. The in ovo silencing was achieved by introducing lentivirus expressing PPAR alpha siRNA into ED2 chicken embryo via microinjection (0.05ul/g egg weight). Transfection efficacy was confirmed by fluorescent microscopy and western blotting...
September 14, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28934688/fulvic-acid-anchored-layered-double-hydroxides-a-multifunctional-composite-adsorbent-for-the-removal-of-anionic-dye-and-toxic-metal
#16
Lei Li, Guangxia Qi, Bangda Wang, Dongbei Yue, Yi Wang, Tsutomu Sato
A novel multifunctional composite adsorbent which possesses the ability for anion exchange and toxic metal complexation has been synthesized by the hybridization of layered double hydroxides (LDH) and fulvic acid (FA) in this study. The results show that FA with lots of functional groups can be effectively and stably anchored on the surface of LDH through coagulation process without occupying the interlayer of LDH. Therefore, the anion exchange ability remains and the adsorption capacity of Orange II can reach 1...
September 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28934677/evaluation-of-participatory-planning-lessons-from-hungarian-natura-2000-management-planning-processes
#17
Eszter Kovács, Eszter Kelemen, Gabriella Kiss, Ágnes Kalóczkai, Veronika Fabók, Barbara Mihók, Boldizsár Megyesi, György Pataki, Barbara Bodorkós, Bálint Balázs, Györgyi Bela, Katalin Margóczi, Ágnes Roboz, Dániel Molnár
Stakeholder participation in nature conservation policies and especially in the management of protected areas has gained importance in the last decades. These changes are underlined by democratic principles and the perceived contribution of stakeholder involvement to the effectiveness of conservation management. Evaluating participatory processes is essential to learn about the past and thus increase the quality of future processes. The evaluation can be useful for the organisations responsible for planning and management, stakeholders and policy makers as well...
September 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28934676/simultaneous-biofiltration-of-btex-and-hg%C3%A2-from-a-petrochemical-waste-stream
#18
Mostafa Leili, Sima Farjadfard, George A Sorial, Bahman Ramavandi
A biofiltration system was developed to treat benzene, toluene, ethylbenzene, and xylene (BTEX) and Hg° vapour from a petrochemical waste stream during overhaul maintenance. The biofilter compost bed was inoculated with a microbial consortium provided by a petrochemical wastewater treatment plant. The effect of the a BTEX concentration (192.6-973.8 g/m(3)h) and empty bed residence time (EBRT) of 20-100 s were studied under the conditions of steady state, transient, shock BTEX-loading, and off-restart. The findings revealed that during a biofilter start-up, an increase in the influent BTEX concentration to around 334...
September 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28934671/the-hnf1a-mutant-ala180val-clinical-challenges-in-determining-causality-of-a-rare-hnf1a-variant-in-familial-diabetes
#19
J V Sagen, L Bjørkhaug, B I Haukanes, L Grevle, J Molnes, B G Nedrebø, O Søvik, P R Njølstad, S Johansson, A Molven
AIMS: Heterozygous mutations in hepatocyte nuclear factor-1A (HNF1A) cause maturity-onset diabetes of the young type 3 (MODY3). Our aim was to compare two families with suspected dominantly inherited diabetes and a new HNF1A variant of unknown clinical significance. METHODS: The HNF1A gene was sequenced in two independently recruited families from the Norwegian MODY Registry. Both familes were phenotyped clinically and biochemically. Microsatellite markers around and within the HNF1A locus were used for haplotyping...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28934651/persulfate-enhanced-photocatalytic-degradation-of-bisphenol-a-by-g-c3n4-nanosheets-under-visible-light-irradiation
#20
Bochuan Liu, Meng Qiao, Yanbin Wang, Lijuan Wang, Yan Gong, Tao Guo, Xu Zhao
The enhancement of g-C3N4 photocatalytic degradation of bisphenol A (BPA) via persulfate (PS) addition was investigated under visible light irradiation. The effects of various parameters on the BPA degradation were investigated, such as catalysts dosage, PS concentrations, initial pH value and BPA concentration. The results showed that g-C3N4 nanosheets exhibited superior photocatalytic activity toward BPA degradation as compared with bulk g-C3N4. The addition of PS can further improve the g-C3N4 photocatalytic performance for BPA degradation...
September 4, 2017: Chemosphere
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