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https://www.readbyqxmd.com/read/28551920/-women-s-cardiac-health-from-theory-to-activism
#1
REVIEW
Avital Porter
Cardiovascular disease (CVD) is the leading cause of death in the western world, in both genders. Although awareness of the importance of prevention, diagnosis and optimal treatment of CVD has risen in general, most women are not fully aware of their CVD risk. Moreover, women are not alert to the burden of risk in their reproductive years (e.g. complicated pregnancy and/or peri-menopausal period) and their impact on future CVD. Unique Female issues such as: fertile age, menopause, oral contraceptives, hormonal and metabolic disorders during pregnancy, labor, as well as psychological matters, and healthy life-style are major contributors to primary and secondary prevention of CVD...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551882/medical-geology-of-endemic-goiter-in-kalutara-sri-lanka-distribution-and-possible-causes
#2
G W A R Fernando, P L C L Liyanage, Anushka Upamali Rajapaksha, Meththika Vithanage
This study assesses the distribution of goiter in the Kalutara District, Sri Lanka in order to find causative factors for the occurrence of goiter even after the salt iodization. A questionnaire survey was conducted at the household level and at the same time iodine and selenium levels of the water sources were analyzed. Questionnaire survey results indicated the highest numbers of goiter patients in the northern part where the lowest were found in the southern sector which may be due to the presence of acid sulfate soils...
May 27, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28551876/identification-and-characterization-of-a-new-agar-degrading-strain-with-the-novel-properties-of-saccharides-inhibition-and-nitrogen-fixation
#3
Hao Wu, Guiguang Chen, Yaxi Bian, Wei Zeng, Bihong Sun, Zhiqun Liang
In this study, a new agar-degrading strain was isolated from soil with agar as a sole carbon source and energy. Based on its morphological, physiological, biochemical characterization and 16S rDNA sequence, the strain was identified as Streptomyces lavendulae UN-8. The extracellular agarase activity reached 0.03 U/ml after fermentation in shake flask (250 ml), which was close to other reported non-marine microorganisms. Furthermore, it is interesting that the growth of UN-8 would be inhibited by glucose (40 g/L) and maltose (40 g/L) with the inhibitory rate of 100% and 70%, respectively...
June 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28551873/achromobacter-panacis-sp-nov-isolated-from-rhizosphere-of-panax-ginseng
#4
Priyanka Singh, Yeon Ju Kim, Hina Singh, Mohamed El-Agamy Farh, Deok-Chun Yang
A novel strain DCY105(T) was isolated from soil collected from the rhizosphere of ginseng (Panax ginseng), in Gochang, Republic of Korea. Strain DCY105(T) is Gram-reaction-negative, white, non-motile, non-flagellate, rod-shaped and aerobic. The bacteria grow optimally at 30°C, pH 6.5-7.0 and in the absence of NaCl. Phylogenetically, strain DCY105(T) is most closely related to Achromobacter marplatensis LMG 26219(T) (96.81%). The DNA G+C content of strain DCY105(T) was 64.4 mol%. Ubiquinone 8 was the major respiratory quinone, and phosphatidylethanolamine, phosphatidylglycerol, and diphosphatidylglycerol were amongst the major polar lipids...
June 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28551856/model-based-intensification-of-a-fed-batch-microbial-process-for-the-maximization-of-polyhydroxybutyrate-phb-production-rate
#5
Giannis Penloglou, Athina Vasileiadou, Christos Chatzidoukas, Costas Kiparissides
An integrated metabolic-polymerization-macroscopic model, describing the microbial production of polyhydroxybutyrate (PHB) in Azohydromonas lata bacteria, was developed and validated using a comprehensive series of experimental measurements. The model accounted for biomass growth, biopolymer accumulation, carbon and nitrogen sources utilization, oxygen mass transfer and uptake rates and average molecular weights of the accumulated PHB, produced under batch and fed-batch cultivation conditions. Model predictions were in excellent agreement with experimental measurements...
May 27, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28551854/tuning-and-elucidation-of-the-colony-dimorphism-in-rhodococcus-ruber-associated-with-cell-flocculation-in-large-scale-fermentation
#6
Song Jiao, Jie Chen, Huimin Yu, Zhongyao Shen
Prevention of cell flocculation in large-scale fermentation is of great importance for most industrial microbes. Using Rhodococcus ruber TH3 as a model strain, we revealed that the undesired cell flocculation in a fermenter was associated with the colony dimorphism phenomenon, and it only occurred in the rough-type of cells (R-TH3) instead of the smooth-type of cells (S-TH3). By analyzing the transcriptome differences of R-TH3 and S-TH3, six representative genes with significantly upregulated transcription in S-TH3 were selected and overexpressed in R-TH3...
May 27, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28551843/incidence-and-risk-factors-of-febrile-neutropenia-in-patients-with-non-hodgkin-b-cell-lymphoma-receiving-r-chop-in-a-single-center-in-japan
#7
Masahiro Yokoyama, Yoshiharu Kusano, Anna Takahashi, Norihito Inoue, Kyoko Ueda, Noriko Nishimura, Yuko Mishima, Yasuhito Terui, Tomoyuki Nukada, Takanobu Nomura, Kiyohiko Hatake
PURPOSE: The incidence of and risk factors for febrile neutropenia (FN) in Japanese non-Hodgkin B-cell lymphoma (B-NHL) patients receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and predonisolone (R-CHOP) chemotherapy are unknown. We conducted this study to address this issue. METHODS: In this single-center, retrospective, observational study, 466 patients with B-NHL who completed an R-CHOP regimen within a 7-year period and who planned to undergo at least three cycles of this regimen were analyzed...
May 27, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28551828/rate-and-mode-of-screw-misplacements-after-3d-fluoroscopy-navigation-assisted-insertion-and-3d-imaging-control-of-1547-pedicle-screws-in-spinal-levels-t10-s1-related-to-vertebrae-and-spinal-sections
#8
Horst Balling, Thomas R Blattert
PURPOSE: In the field of spinal surgery, 3D-fluoroscopy navigation-assisted pedicle screw (PS) insertion with intra-operative 3D-image control represents a modern application of contemporary navigation technology. In literature, sectional or vertebral accuracy limitations of this image-guidance approach are not profoundly specified. This observational study explicitly differentiates accuracy rates and misplacement mode between spinal sections and single vertebrae from T10 to S1 using a navigation-assisted approach...
May 27, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28551814/macrophage-derived-interleukin-1beta-promotes-human-breast-cancer-cell-migration-and-lymphatic-adhesion-in-vitro
#9
Sarah J Storr, Sabreena Safuan, Narmeen Ahmad, Mohammed El-Refaee, Andrew M Jackson, Stewart G Martin
Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis. This study investigates the role of macrophage-derived, caspase-1-dependent interleukin-1beta (IL-1β) in an in vitro model of LVI. IL-1β significantly augmented the adhesion and transmigration of breast cancer cell lines MCF7 and MDA-MB-231 across endothelial cell barriers. MDA-MB-231 and MCF7 showed a higher percentage of adhesion to lymphatic endothelial cells than blood endothelial cells following endothelial cell IL-1β stimulation (P < 0...
May 27, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28551812/utilization-of-starch-enriched-brewery-rice-wine-waste-for-mixotrophic-cultivation-of-ettlia-sp-yc001-used-in-biodiesel-production
#10
Yeji Kam, Mina Sung, Hoon Cho, Chang-Min Kang, Jungmin Kim, Jong-In Han
Starch-enriched brewery waste (SBW), an unexplored feedstock, was investigated as a nutritious low-cost source for the mixotrophic cultivation of Ettlia sp. YC001 for biodiesel production. Stirring, autoclaving, and sonication were assessed for the SBW, in conjunction with pH. Stirring at 55 °C was found to be the best, in terms of the effectiveness of starch hydrolysis and yeast disintegration as well as cost. The treated solutions were found to support the mixotrophic growth of microalgae: 20 g/L of glucose medium resulted in the highest biomass production of 9...
May 27, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28551811/enzymatic-properties-of-alginate-lyase-from-paenibacillus-sp-s29
#11
Masahiro Kurakake, Yuhei Kitagawa, Atsushi Okazaki, Kazuyuki Shimizu
Paenibacillus sp. S29 was isolated from soil and produces an alginate lyase. The molecular weight of this enzyme was 32 kDa and the N-terminal amino acid sequence was ASVTKST. The optimal pH was approximately 8.7 and the enzyme was stable over a pH range of 5.6 to 8.8 at 40 °C for 60 min. The optimal temperature was approximately 50 °C, and the residual activity was not decreased at temperatures of up to 40 °C at pH 8 for 30 min. Paenibacillus sp. S29 alginate lyase had also a little activity toward hyaluronic acid...
May 27, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28551808/mitochondrial-heteroplasmy
#12
George B Stefano, Christina Bjenning, Fuzhou Wang, Nan Wang, Richard M Kream
Genetic polymorphisms, in concert with well-characterized etiology and progression of major pathologies, plays a significant role in aberrant processes afflicting human populations. Mitochondrial heteroplasmy represents a dynamically determined co-expression of inherited polymorphisms and somatic pathology in varying ratios within individual mitochondrial DNA (mtDNA) genomes with repetitive patterns of tissue specificity. The ratios of the MtDNA genomes represent a balance between healthy and pathological cellular outcomes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551797/peripheral-blood-mitochondrial-dna-and-myocardial-function
#13
Tatiana Kuznetsova, Judita Knez
Heart failure is a complex progressive clinical syndrome which is initiated by risk factors (e.g., hypertension, obesity, and diabetes), then proceeds to asymptomatic maladaptive left ventricular remodeling and dysfunction, and finally evolves into clinically overt, symptomatic heart failure, disability, and death. The progression of left ventricular dysfunction is associated with changes in cardiac energy metabolism. Mitochondria play a central role in a variety of cardiomyocytes functions, including oxidative energy production, storage of calcium ions, and programmed cell death...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551796/nitrite-nitric-oxide-signaling-and-cardioprotection
#14
Matthias Totzeck, Ulrike B Hendgen-Cotta, Tienush Rassaf
Cardioprotective strategies to prevent damage to mitochondria in acute myocardial infarction are warranted to reduce lethal myocardial ischemia/reperfusion (I/R) injury. Mitochondrial antagonists in I/R are reactive oxygen species (ROS), deteriorated calcium signaling, permeabilization of the mitochondrial outer membrane (MOM) and deranged mitochondrial structural dynamism (fusion and fission). Nitric oxide (NO) related signaling can protect hearts from I/R. Albeit the underlying signaling is incompletely resolved, recent data point to a particular involvement of protective posttranslational modification of mitochondrial elements...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551791/mitochondrial-mechanosensor-microdomains-in-cardiovascular-disorders
#15
Michele Miragoli, Aderville Cabassi
The cardiomyocytes populating the 'working myocardium' are highly organized and such organization ranges from macroscale (e.g. the geometrical rod shape) to microscale (dyad/t-tubules) domains. This meticulous level of organization is imperative for assuring the normal and physiological pump-function of the heart. In the pathological cardiac tissue, the domains-related architecture is partially lost, resulting in morphological, electrical and metabolic remodeling and promoting cardiovascular diseases including heart failure and arrhythmias...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551779/functional-implications-of-cardiac-mitochondria-clustering
#16
Felix T Kurz, Miguel A Aon, Brian O'Rourke, Antonis A Armoundas
The spatio-temporal organization of mitochondria in cardiac myocytes facilitates myocyte-wide, cluster-bound, mitochondrial inner membrane potential oscillatory depolarizations, commonly triggered by metabolic or oxidative stressors. Local intermitochondrial coupling can be mediated by reactive oxygen species (ROS) that activate inner membrane pores to initiate a ROS-induced-ROS-release process that produces synchronized limit cycle oscillations of mitochondrial clusters within the whole mitochondrial network...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551770/quality-of-life-following-prophylactic-gynecological-surgery-experiences-of-female-lynch-mutation-carriers
#17
Holly Etchegary, Elizabeth Dicks, Laura Tamutis, Lesa Dawson
Lynch syndrome (LS) is a genetic condition conferring an elevated risk of gastrointestinal, gynecologic and other malignancies, often before the age of 50. Current guidelines recommend prophylactic gynecologic surgery to manage inherited cancers for female mutation carriers. Data is lacking on women's quality of life following surgery. In this pilot study, we explored how women described their quality of life post-prophylactic gynecologic surgery and the factors that affected post-surgery experiences. A qualitative interview study was the chosen design...
May 27, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28551749/neuroanatomy-and-neuropathology-of-autism-spectrum-disorder-in-humans
#18
Christine Ecker, Michael J Schmeisser, Eva Loth, Declan G Murphy
Autism spectrum disorder (ASD) is a lifelong heterogeneous neurodevelopmental condition that is associated with differences in brain anatomy and connectivity. Yet, the molecular and cellular mechanisms that underpin the atypical developmental of the brain in ASD remain poorly understood. Here, we review the findings of in vivo neuroimaging studies examining the time course of atypical brain development in ASD and relate the different neurodevelopmental stages that are atypical in ASD to the known neurobiological mechanisms that drive the maturation of the typically developing brain...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28551747/damage-to-the-microbial-cell-membrane-during-pyrolytic-sugar-utilization-and-strategies-for-increasing-resistance
#19
Tao Jin, Marjorie R Rover, Elspeth M Petersen, Zhanyou Chi, Ryan G Smith, Robert C Brown, Zhiyou Wen, Laura R Jarboe
Lignocellulosic biomass is an appealing feedstock for the production of biorenewable fuels and chemicals, and thermochemical processing is a promising method for depolymerizing it into sugars. However, trace compounds in this pyrolytic sugar syrup are inhibitory to microbial biocatalysts. This study demonstrates that hydrophobic inhibitors damage the cell membrane of ethanologenic Escherichia coli KO11+lgk. Adaptive evolution was employed to identify design strategies for improving pyrolytic sugar tolerance and utilization...
May 27, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28551732/bradyrhizobium-brasilense-sp-nov-a-symbiotic-nitrogen-fixing-bacterium-isolated-from-brazilian-tropical-soils
#20
Elaine Martins da Costa, Amanda Azarias Guimarães, Rayssa Pereira Vicentin, Paula Rose de Almeida Ribeiro, Aniele Carolina Ribas Leão, Eduardo Balsanelli, Liesbeth Lebbe, Maarten Aerts, Anne Willems, Fatima Maria de Souza Moreira
Four strains of rhizobia isolated from nodules of Vigna unguiculata (UFLA03-321(T), UFLA03-320 and UFLA03-290) and Macroptilium atropurpureum (UFLA04-0212) in Brazilian soils were previously reported as a new group within the genus Bradyrhizobium. To determine their taxonomic position, these strains were characterized in this study using a polyphasic approach. The analysis of the 16S rRNA gene grouped the four strains with Bradyrhizobium pachyrhizi PAC48(T). However, the concatenated sequence analysis of the two (recA and glnII) or three (atpD, gyrB and recA) housekeeping genes indicated that these strains represent a novel species of Bradyrhizobium, which is very closely related to B...
May 27, 2017: Archives of Microbiology
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