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https://www.readbyqxmd.com/read/28735508/initiating-insulin-how-to-help-people-with-type-2-diabetes-start-and-continue-insulin-successfully
#1
William H Polonsky, Joyce Arsenault, Lawrence Fisher, Pamela Kushner, Eden M Miller, Teresa L Pearson, Mariusz Tracz, Stewart Harris, Norbert Hermanns, Bernd-M Scholz, Robyn K Pollom, Magaly Perez-Nieves, Roy Daniel Pollom, Irene Hadjiyianni
No abstract text is available yet for this article.
July 23, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28735501/step-by-step-guide-to-do-a-systematic-review-and-meta-analysis-for-medical-professionals
#2
Y Bashir, K C Conlon
INTRODUCTION: Systematic review and meta-analysis are statistical tools used to review researches performed on a same topic. They extract the collective effect of the studies performed on the topic of interest after statistically analysing the data of all the studies included. AIMS AND OBJECTIVES: Systematic reviews and meta-analysis are getting more and more popular in the medical field. Statistics is never the strong aspect of medical professionals, and facing a large number of statistical tests and values could be quite confusing for them...
July 22, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28735472/assessment-of-soils-contamination-with-veterinary-antibiotic-residues-in-northern-poland-using-developed-mae-spe-lc-ms-ms-methods
#3
Paulina Łukaszewicz, Jolanta Kumirska, Anna Białk-Bielińska, Joanna Dołżonek, Piotr Stepnowski
Among the wide range of compounds reaching the soil are the veterinary antimicrobials. Since no regulations regarding acceptable levels of drug concentrations in the environment exist, monitoring tests, particularly concerning soils, are carried out very rarely. This study presents a preliminary assessment of the contamination of agricultural soils in Northern Poland with seven antimicrobial veterinary medicines which has never been carried out before. Veterinary drugs were detected in 54% of the examined soil samples; the most commonly detected drugs were sulfonamides and trimethoprim...
July 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28735438/adenosine-assisted-neurovascular-surgery-initial-case-series-and-review-of-literature
#4
REVIEW
Alaa Al-Mousa, Gahan Bose, Katharine Hunt, Ahmed K Toma
Cerebral aneurysms in complex anatomical locations and intraoperative rupture of aneurysms are challenging for neurosurgeons and anaesthetists alike. Mechanical and non-mechanical methods to reduce blood flow into aneurysms are well-recognised techniques to facilitate aneurysm exclusion from the circulation. Mechanical methods like temporary clipping of parent arteries, carotid artery ligation and endovascular balloon occlusion are commonly used in clinical practice. However, non-mechanical techniques such as rapid ventricular pacing and adenosine-induced cardiac standstill with hypotension are still emerging strategies...
July 22, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28735436/assessing-differences-in-macrofaunal-assemblages-as-a-factor-of-sieve-mesh-size-distance-between-samples-and-time-of-sampling
#5
Lenaïg G Hemery, Kristin K Politano, Sarah K Henkel
With increasing cascading effects of climate change on the marine environment, as well as pollution and anthropogenic utilization of the seafloor, there is increasing interest in tracking changes to benthic communities. Macrofaunal surveys are traditionally conducted as part of pre-incident environmental assessment studies and post-incident monitoring studies when there is a potential impact to the seafloor. These surveys usually characterize the structure and/or spatiotemporal distribution of macrofaunal assemblages collected with sediment cores; however, many different sampling protocols have been used...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28735435/examination-of-honeys-and-flowers-as-soil-element-indicators
#6
Nikolett Czipa, Gerda Diósi, Clive Phillips, Béla Kovács
Detection of soil element deficiencies is time consuming, requiring a major commitment for field work and analysis. Bees concentrate some elements in their honey which could allow soil element concentrations to be predicted without having to take large numbers of soil samples. We measured 14 element concentrations in soil, sunflower, acacia flower and honey samples from two different regions of Hungary. Across sites, the elements with significant correlation coefficients between honey and soil concentrations, in descending order of probability, were Cu > Ba >Sr = Ni > Zn > Mn = Pb >As...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28735417/design-and-properties-of-an-immobilization-enzyme-system-for-inulin-conversion
#7
Hua Hang, Changbao Wang, Yiqun Cheng, Ning Li, Liuli Song
A commercial inulinase could convert inulin into fructose, which was optimized to be entrapped in the calcium alginate-gelatin beads with the immobilization yield of 86% for free inulinase activities. The optimum pH values and temperatures were 4.5 and 40 °C for the free enzyme and 5.0-5.5 and 45-50 °C for the immobilized enzyme. The kinetic parameters of V max and K m were 5.24 μmol/min and 57.6 mg/mL for the free inulinase and 4.32 μmol/min and 65.8 mg/mL for the immobilized inulinase, respectively...
July 22, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28735400/zymographic-method-for-distinguishing-different-classes-of-superoxide-dismutases-in-plants
#8
Ashwini R Jamdhade, Ramanjulu Sunkar, Vandana K Hivrale
In plants, especially in chloroplasts, superoxide radical is generated when an electron is transferred to dimolecular O2 due to decreased activity of Photosystem I. The superoxide (O2(-)) radical accumulation is more rampant in plants exposed to abiotic stresses due to oxidation of photosystem components. Excessive superoxide radical accumulation will lead to oxidative damage to the cellular macromolecules. The ubiquitous superoxide dismutases (SODs) represent critical enzymatic antioxidant system present in cells, which can catalyze the disproportion of superoxide (O2(-)) radical rapidly into hydrogen peroxide (H2O2) and molecular oxygen...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28735375/perioperative-practices-concerning-one-anastomosis-mini-gastric-bypass-a-survey-of-210-surgeons
#9
Kamal K Mahawar, Kuldeepak Singh Kular, Chetan Parmar, Michael Van den Bossche, Yitka Graham, William R J Carr, Brijesh Madhok, Conor Magee, Sanjay Purkayastha, Peter K Small
BACKGROUND: There is currently little evidence available on the perioperative practices concerning one anastomosis/mini gastric bypass (OAGB/MGB) and no published consensus amongst experts. Even the published papers are not clear on these aspects. The purpose of this study was to understand various perioperative practices concerning OAGB/MGB. METHODS: Bariatric surgeons from around the world were invited to participate in a questionnaire-based survey. Only surgeons performing this procedure were included...
July 22, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28735368/mdma-induced-indifference-to-negative-sounds-is-mediated-by-the-5-ht2a-receptor
#10
K P C Kuypers, R de la Torre, Farre, N Pizarro, L Xicota, J G Ramaekers
BACKGROUND: MDMA has been shown to induce feelings of sociability, a positive emotional bias and enhanced empathy. While previous research has used only visual emotional stimuli, communication entails more than that single dimension and it is known that auditory information is also crucial in this process. In addition, it is, however, unclear what the neurobiological mechanism underlying these MDMA effects on social behaviour is. Previously, studies have shown that MDMA-induced emotional excitability and positive mood are linked to the action on the serotonin (5-HT) 2A receptor...
July 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28735366/further-validation-of-the-affective-bias-test-for-predicting-antidepressant-and-pro-depressant-risk-effects-of-pharmacological-and-social-manipulations-in-male-and-female-rats
#11
Justyna K Hinchcliffe, Sarah A Stuart, Michael Mendl, Emma S J Robinson
RATIONALE: Affective biases are hypothesised to contribute to the cause and treatment of mood disorders. We have previously found that affective biases, associated with learning and memory, are observed following acute treatments with a range of antidepressant and pro-depressant manipulations. OBJECTIVE: This study aimed to test if similar biases are observed in male and female Sprague Dawley (SD) rats. We also test whether the stress hormone, corticosterone, induces a negative bias in the affective bias test (ABT) consistent with its putative role in the development of depression...
July 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28735353/non-vitamin-k-oral-anticoagulants-noacs-and-their-reversal
#12
REVIEW
Sujan T Reddy, T C Cossey, Sean I Savitz, James C Grotta
PURPOSE OF REVIEW: An 80-year-old man presents with an acute right hemiparesis and National Institutes of Health Stroke Scale (NIHSS) of 25, 14 h after taking dabigatran. Activated partial thromboplastin time (aPTT) is 42.8 s. Arteriogram demonstrates left internal carotid artery thrombosis. What is the appropriate management of this patient with acute ischemic stroke while on a NOAC? RECENT FINDINGS: Idarucizumab is a reversal agent approved for dabigatran, and two more reversal agents, andexanet alfa and aripazine, are currently in development for NOACs...
September 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28735298/foxp1-related-intellectual-disability-syndrome-a-recognisable-entity
#13
Ilse Meerschaut, Daniel Rochefort, Nicole Revençu, Justine Pètre, Christina Corsello, Guy A Rouleau, Fadi F Hamdan, Jacques L Michaud, Jenny Morton, Jessica Radley, Nicola Ragge, Sixto García-Miñaúr, Pablo Lapunzina, Maria Palomares Bralo, Maria Ángeles Mori, Stéphanie Moortgat, Valérie Benoit, Sandrine Mary, Nele Bockaert, Ann Oostra, Olivier Vanakker, Milen Velinov, Thomy Jl de Ravel, Djalila Mekahli, Jonathan Sebat, Keith K Vaux, Nataliya DiDonato, Andrea K Hanson-Kahn, Louanne Hudgins, Bruno Dallapiccola, Antonio Novelli, Luigi Tarani, Joris Andrieux, Michael J Parker, Katherine Neas, Berten Ceulemans, An-Sofie Schoonjans, Darina Prchalova, Marketa Havlovicova, Miroslava Hancarova, Magdalena Budisteanu, Annelies Dheedene, Björn Menten, Patrick A Dion, Damien Lederer, Bert Callewaert
BACKGROUND: Mutations in forkhead box protein P1 (FOXP1) cause intellectual disability (ID) and specific language impairment (SLI), with or without autistic features (MIM: 613670). Despite multiple case reports no specific phenotype emerged so far. METHODS: We correlate clinical and molecular data of 25 novel and 23 previously reported patients with FOXP1 defects. We evaluated FOXP1 activity by an in vitro luciferase model and assessed protein stability in vitro by western blotting...
July 22, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28735290/membrane-tethered-metalloproteinase-expressed-by-vascular-smooth-muscle-cells-limits-the-progression-of-proliferative-atherosclerotic-lesions
#14
Richard H Barnes, Takeshi Akama, Miina K Öhman, Moon-Sook Woo, Julian Bahr, Stephen J Weiss, Daniel T Eitzman, Tae-Hwa Chun
BACKGROUND: The MMP (matrix metalloproteinase) family plays diverse and critical roles in directing vascular wall remodeling in atherosclerosis. Unlike secreted-type MMPs, a member of the membrane-type MMP family, MT1-MMP (membrane-type 1 MMP; MMP14), mediates pericellular extracellular matrix degradation that is indispensable for maintaining physiological extracellular matrix homeostasis. However, given the premature mortality exhibited by MT1-MMP-null mice, the potential role of the proteinase in atherogenesis remains elusive...
July 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28735272/perceived-nicotine-content-of-reduced-nicotine-content-cigarettes-is-a-correlate-of-perceived-health-risks
#15
Lauren R Pacek, F Joseph McClernon, Rachel L Denlinger-Apte, Melissa Mercincavage, Andrew A Strasser, Sarah S Dermody, Ryan Vandrey, Tracy T Smith, Natalie Nardone, Dorothy K Hatsukami, Joseph S Koopmeiners, Rachel V Kozink, Eric C Donny
BACKGROUND: Reducing cigarette nicotine content may reduce smoking. Studies suggest that smokers believe that nicotine plays a role in smoking-related morbidity. This may lead smokers to assume that reduced nicotine means reduced risk, and attenuate potential positive effects on smoking behaviour. METHODS: Data came from a multisite randomised trial in which smokers were assigned to use cigarettes varying in nicotine content for 6 weeks. We evaluated associations between perceived and actual nicotine content with perceived health risks using linear regression, and associations between perceived nicotine content and perceived health risks with smoking outcomes using linear and logistic regression...
July 22, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28735269/patient-family-agreement-on-values-and-preferences-for-life-sustaining-treatment-results-of-a-multicentre-observational-study
#16
Amane Abdul-Razzak, Daren K Heyland, Jessica Simon, Sunita Ghosh, Andrew G Day, John J You
OBJECTIVES: To quantify agreement between patients and their family members on their own values and preferences for use or non-use of life-sustaining treatments for the patient. METHODS: Hospitalised patients aged 55 years or older with advanced pulmonary, cardiac, liver disease or metastatic cancer or aged 80 years or older from medical wards at 16 Canadian hospitals and their family members completed a questionnaire including eight items about values related to life-sustaining treatment and a question about preferences for life-sustaining treatments...
July 22, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28735249/to-defer-or-not-to-defer-that-is-the-question
#17
Henning Kelbæk, Dan Eik Høfsten, Thomas Engstrøm
No abstract text is available yet for this article.
July 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28735233/a-model-system-to-mimic-environmentally-active-surface-film-roughness-and-hydrophobicity
#18
Jacob S Grant, Scott K Shaw
This work presents the development and initial assessment of a laboratory platform to allow quantitative studies on model urban films. The platform consists of stearic acid and eicosane mixtures that are solution deposited from hexanes onto smooth, solid substrates. We show that this model has distinctive capabilities to better mimic a naturally occurring film's morphology and hydrophobicity, two important parameters that have not previously been incorporated into model film systems. The physical and chemical properties of the model films are assessed using a variety of analytical instruments...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28735207/nutrient-balancing-for-phytoremediation-enhancement-of-urea-manufacturing-raw-wastewater
#19
Sara Yavari, Amirhossein Malakahmad, Nasiman B Sapari, Saba Yavari, Eakalak Khan
Application of urea manufacturing wastewater to teak (Tectona grandis) trees, a fast growing tropical timber plants, is an environmentally-friendly and cost-effective alternative for treatment of nitrogen-rich wastewater. However, the plant growth is strongly limited by lack of phosphorus (P) and potassium (K) elements when the plants are irrigated with wastewater containing high concentration of nitrogen (N). A greenhouse experiment was conducted to optimize the efficiency of teak-based remediation systems in terms of nutrient balance...
July 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28735200/ion-specific-hydration-in-nano-confined-electrical-double-layers
#20
Z Zachariah, R M Espinosa-Marzal, M P Heuberger
We probe counter-ion specific effects in nano-confined electrical-double-layers (EDLs) by means of direct force measurements across a model slit pore in the extended surface forces apparatus. By variation of solution composition, we compare four different counter-ions with dissimilar hydration properties, namely Na(+), K(+), Cs(+) as well as H3O(+), all confined between (001) mica surfaces. We discuss the results in terms of a recently proposed π-transition model, evoking hydrated ion layering as the recurrent structural element in highly confined EDLs...
July 14, 2017: Journal of Colloid and Interface Science
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